Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Evan David Rosen, Ph.D., M.D.


Adipose Tissue Biology [login at prompt]
Available: 07/01/22, Expires: 09/30/26

The student will assist in basic and translational research related to adipose tissue development, physiology, and pathophysiology.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK126789 (ROSEN, EVAN D) Jul 15, 2021 - Apr 30, 2025
    Regulation of Adipose-Lymphatic Cross-talk
    Role: Principal Investigator
  2. RC2DK116691 (ROSEN, EVAN D) Apr 23, 2018 - Mar 31, 2023
    Generation of a Cellular Atlas of Adipose Tissue in Mouse and Man
    Role: Principal Investigator
  3. R01DK113669 (ROSEN, EVAN D) Mar 1, 2017 - Feb 28, 2021
    TGFbeta-mediated Transcriptional Reprogramming of Mature Adipocytes in Obesity
    Role: Principal Investigator
  4. R01DK102170 (ROSEN, EVAN D) Apr 1, 2015 - Aug 31, 2025
    Role of IRF3 in Energy and Glucose Homeostasis
    Role: Principal Investigator
  5. R01DK102173 (ROSEN, EVAN D) Apr 1, 2015 - Jan 31, 2023
    Transcriptional Mechanisms of Human Insulin Resistance
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Xiao H, Bozi LHM, Sun Y, Riley CL, Philip VM, Chen M, Li J, Zhang T, Mills EL, Emont MP, Sun W, Reddy A, Garrity R, Long J, Becher T, Vitas LP, Laznik-Bogoslavski D, Ordonez M, Liu X, Chen X, Wang Y, Liu W, Tran N, Liu Y, Zhang Y, Cypess AM, White AP, He Y, Deng R, Schöder H, Paulo JA, Jedrychowski MP, Banks AS, Tseng YH, Cohen P, Tsai LT, Rosen ED, Klein S, Chondronikola M, McAllister FE, Van Bruggen N, Huttlin EL, Spiegelman BM, Churchill GA, Gygi SP, Chouchani ET. Architecture of the outbred brown fat proteome defines regulators of metabolic physiology. Cell. 2022 Nov 23; 185(24):4654-4673.e28. PMID: 36334589.
    Citations: 1     Fields:    Translation:HumansAnimals
  2. Patel SJ, Liu N, Piaker S, Gulko A, Andrade ML, Heyward FD, Sermersheim T, Edinger N, Srinivasan H, Emont MP, Westcott GP, Luther J, Chung RT, Yan S, Kumari M, Thomas R, Deleye Y, Tchernof A, White PJ, Baselli GA, Meroni M, De Jesus DF, Ahmad R, Kulkarni RN, Valenti L, Tsai L, Rosen ED. Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b. Sci Transl Med. 2022 03 23; 14(637):eabh3831. PMID: 35320000; PMCID: PMC9162056.
    Citations:    Fields:    Translation:Animals
  3. Emont MP, Jacobs C, Essene AL, Pant D, Tenen D, Colleluori G, Di Vincenzo A, Jørgensen AM, Dashti H, Stefek A, McGonagle E, Strobel S, Laber S, Agrawal S, Westcott GP, Kar A, Veregge ML, Gulko A, Srinivasan H, Kramer Z, De Filippis E, Merkel E, Ducie J, Boyd CG, Gourash W, Courcoulas A, Lin SJ, Lee BT, Morris D, Tobias A, Khera AV, Claussnitzer M, Pers TH, Giordano A, Ashenberg O, Regev A, Tsai LT, Rosen ED. A single-cell atlas of human and mouse white adipose tissue. Nature. 2022 03; 603(7903):926-933. PMID: 35296864; PMCID: PMC9504827.
    Citations: 12     Fields:    Translation:HumansAnimals
  4. Westcott GP, Rosen ED. Crosstalk Between Adipose and Lymphatics in Health and Disease. Endocrinology. 2022 01 01; 163(1). PMID: 34718498; PMCID: PMC8599804.
    Citations:    Fields:    Translation:HumansAnimalsCells
  5. Jiang Z, Zhao M, Voilquin L, Jung Y, Aikio MA, Sahai T, Dou FY, Roche AM, Carcamo-Orive I, Knowles JW, Wabitsch M, Appel EA, Maikawa CL, Camporez JP, Shulman GI, Tsai L, Rosen ED, Gardner CD, Spiegelman BM, Svensson KJ. Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis. Cell Metab. 2021 09 07; 33(9):1836-1852.e11. PMID: 34348115; PMCID: PMC8429235.
    Citations: 3     Fields:    Translation:AnimalsCells
  6. Westcott GP, Emont MP, Li J, Jacobs C, Tsai L, Rosen ED. Mesothelial cells are not a source of adipocytes in mice. Cell Rep. 2021 07 13; 36(2):109388. PMID: 34260927; PMCID: PMC8317472.
    Citations: 4     Fields:    Translation:AnimalsCells
  7. Li J, Li E, Czepielewski RS, Chi J, Guo X, Han YH, Wang D, Wang L, Hu B, Dawes B, Jacobs C, Tenen D, Lin SJ, Lee B, Morris D, Tobias A, Randolph GJ, Cohen P, Tsai L, Rosen ED. Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells. Cell Metab. 2021 07 06; 33(7):1449-1465.e6. PMID: 34038712; PMCID: PMC8266750.
    Citations: 7     Fields:    Translation:AnimalsCells
  8. Yan S, Kumari M, Xiao H, Jacobs C, Kochumon S, Jedrychowski M, Chouchani E, Ahmad R, Rosen ED. IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis. J Clin Invest. 2021 04 01; 131(7). PMID: 33571167; PMCID: PMC8011904.
    Citations: 8     Fields:    Translation:AnimalsCells
  9. Lontchi-Yimagou E, Kang S, Goyal A, Zhang K, You JY, Carey M, Jain S, Bhansali S, Kehlenbrink S, Guo P, Rosen ED, Kishore P, Hawkins M. Insulin-sensitizing effects of vitamin D repletion mediated by adipocyte vitamin D receptor: Studies in humans and mice. Mol Metab. 2020 12; 42:101095. PMID: 33045433.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  10. Roh HC, Kumari M, Taleb S, Tenen D, Jacobs C, Lyubetskaya A, Tsai LT, Rosen ED. Adipocytes fail to maintain cellular identity during obesity due to reduced PPAR? activity and elevated TGFß-SMAD signaling. Mol Metab. 2020 12; 42:101086. PMID: 32992037.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  11. Hall JA, Ramachandran D, Roh HC, DiSpirito JR, Belchior T, Zushin PH, Palmer C, Hong S, Mina AI, Liu B, Deng Z, Aryal P, Jacobs C, Tenen D, Brown CW, Charles JF, Shulman GI, Kahn BB, Tsai LTY, Rosen ED, Spiegelman BM, Banks AS. Obesity-Linked PPAR? S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3. Cell Metab. 2020 10 06; 32(4):665-675.e6. PMID: 32941798.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  12. Jiao Y, Ahmed U, Sim MFM, Bejar A, Zhang X, Talukder MMU, Rice R, Flannick J, Podgornaia AI, Reilly DF, Engreitz JM, Kost-Alimova M, Hartland K, Mercader JM, Georges S, Wagh V, Tadin-Strapps M, Doench JG, Edwardson JM, Rochford JJ, Rosen ED, Majithia AR. Discovering metabolic disease gene interactions by correlated effects on cellular morphology. Mol Metab. 2019 06; 24:108-119. PMID: 30940487; PMCID: PMC6531784.
    Citations: 6     Fields:    Translation:HumansCells
  13. Kazak L, Rahbani JF, Samborska B, Lu GZ, Jedrychowski MP, Lajoie M, Zhang S, Ramsay L, Dou FY, Tenen D, Chouchani ET, Dzeja P, Watson IR, Tsai L, Rosen ED, Spiegelman BM. Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity. Nat Metab. 2019; 1(3):360-370. PMID: 31161155; PMCID: PMC6544051.
    Citations: 47     Fields:    Translation:AnimalsCells
  14. Rosen ED, Kaestner KH, Natarajan R, Patti ME, Sallari R, Sander M, Susztak K. Epigenetics and Epigenomics: Implications for Diabetes and Obesity. Diabetes. 2018 10; 67(10):1923-1931. PMID: 30237160; PMCID: PMC6463748.
    Citations: 46     Fields:    Translation:HumansCells
  15. De Filippis E, Li T, Rosen ED. Exposure of adipocytes to bisphenol-A in vitro interferes with insulin action without enhancing adipogenesis. PLoS One. 2018; 13(8):e0201122. PMID: 30133442.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  16. Kong X, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T, Rosen ED. Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin. Cell Metab. 2018 10 02; 28(4):631-643.e3. PMID: 30078553; PMCID: PMC6170693.
    Citations: 60     Fields:    Translation:AnimalsCells
  17. Roh HC, Tsai LTY, Shao M, Tenen D, Shen Y, Kumari M, Lyubetskaya A, Jacobs C, Dawes B, Gupta RK, Rosen ED. Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity. Cell Metab. 2018 May 01; 27(5):1121-1137.e5. PMID: 29657031; PMCID: PMC5932137.
    Citations: 72     Fields:    Translation:AnimalsCells
  18. Ahmad R, Al-Roub A, Kochumon S, Akther N, Thomas R, Kumari M, Koshy MS, Tiss A, Hannun YA, Tuomilehto J, Sindhu S, Rosen ED. The Synergy between Palmitate and TNF-a for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation. J Immunol. 2018 05 15; 200(10):3599-3611. PMID: 29632147; PMCID: PMC5937214.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  19. Kazak L, Chouchani ET, Lu GZ, Jedrychowski MP, Bare CJ, Mina AI, Kumari M, Zhang S, Vuckovic I, Laznik-Bogoslavski D, Dzeja P, Banks AS, Rosen ED, Spiegelman BM. Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. Cell Metab. 2017 10 03; 26(4):693. PMID: 28978428; PMCID: PMC5638127.
    Citations: 30     Fields:    
  20. Kazak L, Chouchani ET, Lu GZ, Jedrychowski MP, Bare CJ, Mina AI, Kumari M, Zhang S, Vuckovic I, Laznik-Bogoslavski D, Dzeja P, Banks AS, Rosen ED, Spiegelman BM. Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. Cell Metab. 2017 Oct 03; 26(4):660-671.e3. PMID: 28844881.
    Citations: 71     Fields:    Translation:AnimalsCells
  21. Shen Y, Roh HC, Kumari M, Rosen ED. Adipocyte glucocorticoid receptor is important in lipolysis and insulin resistance due to exogenous steroids, but not insulin resistance caused by high fat feeding. Mol Metab. 2017 10; 6(10):1150-1160. PMID: 29031716.
    Citations: 20     Fields:    Translation:AnimalsCells
  22. Kazak L, Chouchani ET, Stavrovskaya IG, Lu GZ, Jedrychowski MP, Egan DF, Kumari M, Kong X, Erickson BK, Szpyt J, Rosen ED, Murphy MP, Kristal BS, Gygi SP, Spiegelman BM. UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction. Proc Natl Acad Sci U S A. 2017 07 25; 114(30):7981-7986. PMID: 28630339.
    Citations: 50     Fields:    Translation:AnimalsCells
  23. Guillermier C, Fazeli PK, Kim S, Lun M, Zuflacht JP, Milian J, Lee H, Francois-Saint-Cyr H, Horreard F, Larson D, Rosen ED, Lee RT, Lechene CP, Steinhauser ML. Imaging mass spectrometry demonstrates age-related decline in human adipose plasticity. JCI Insight. 2017 03 09; 2(5):e90349. PMID: 28289709; PMCID: PMC5333969.
    Citations: 24     Fields:    Translation:HumansCells
  24. Campbell JN, Macosko EZ, Fenselau H, Pers TH, Lyubetskaya A, Tenen D, Goldman M, Verstegen AM, Resch JM, McCarroll SA, Rosen ED, Lowell BB, Tsai LT. A molecular census of arcuate hypothalamus and median eminence cell types. Nat Neurosci. 2017 Mar; 20(3):484-496. PMID: 28166221; PMCID: PMC5323293.
    Citations: 267     Fields:    Translation:AnimalsCells
  25. Roh HC, Tsai LT, Lyubetskaya A, Tenen D, Kumari M, Rosen ED. Simultaneous Transcriptional and Epigenomic Profiling from Specific Cell Types within Heterogeneous Tissues In Vivo. Cell Rep. 2017 01 24; 18(4):1048-1061. PMID: 28122230.
    Citations: 40     Fields:    Translation:AnimalsCells
  26. Majithia AR, Tsuda B, Agostini M, Gnanapradeepan K, Rice R, Peloso G, Patel KA, Zhang X, Broekema MF, Patterson N, Duby M, Sharpe T, Kalkhoven E, Rosen ED, Barroso I, Ellard S, Kathiresan S, O'Rahilly S, Chatterjee K, Florez JC, Mikkelsen T, Savage DB, Altshuler D. Prospective functional classification of all possible missense variants in PPARG. Nat Genet. 2016 12; 48(12):1570-1575. PMID: 27749844; PMCID: PMC5131844.
    Citations: 90     Fields:    Translation:HumansCells
  27. Rosen ED. Epigenomic and transcriptional control of insulin resistance. J Intern Med. 2016 11; 280(5):443-456. PMID: 27739225; PMCID: PMC5119639.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  28. Kumari M, Wang X, Lantier L, Lyubetskaya A, Eguchi J, Kang S, Tenen D, Roh HC, Kong X, Kazak L, Ahmad R, Rosen ED. IRF3 promotes adipose inflammation and insulin resistance and represses browning. J Clin Invest. 2016 08 01; 126(8):2839-54. PMID: 27400129; PMCID: PMC4966307.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  29. Rosen ED. Burning Fat by Bugging the System. N Engl J Med. 2016 Mar 03; 374(9):885-7. PMID: 26962910.
    Citations:    Fields:    Translation:Animals
  30. Kang S, Tsai LT, Rosen ED. Nuclear Mechanisms of Insulin Resistance. Trends Cell Biol. 2016 05; 26(5):341-351. PMID: 26822036; PMCID: PMC4844850.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  31. Rosen ED. Two paths to fat. Nat Cell Biol. 2015 Apr; 17(4):360-1. PMID: 25812519.
    Citations: 7     Fields:    Translation:AnimalsCells
  32. Kang S, Tsai LT, Zhou Y, Evertts A, Xu S, Griffin MJ, Issner R, Whitton HJ, Garcia BA, Epstein CB, Mikkelsen TS, Rosen ED. Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis. Nat Cell Biol. 2015 Jan; 17(1):44-56. PMID: 25503565; PMCID: PMC4281178.
    Citations: 37     Fields:    Translation:AnimalsCells
  33. Majithia AR, Flannick J, Shahinian P, Guo M, Bray MA, Fontanillas P, Gabriel SB, Rosen ED, Altshuler D. Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):13127-32. PMID: 25157153; PMCID: PMC4246964.
    Citations: 84     Fields:    Translation:HumansCells
  34. Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED. IRF4 is a key thermogenic transcriptional partner of PGC-1a. Cell. 2014 Jul 03; 158(1):69-83. PMID: 24995979.
    Citations: 124     Fields:    Translation:HumansAnimalsCells
  35. Long JZ, Svensson KJ, Tsai L, Zeng X, Roh HC, Kong X, Rao RR, Lou J, Lokurkar I, Baur W, Castellot JJ, Rosen ED, Spiegelman BM. A smooth muscle-like origin for beige adipocytes. Cell Metab. 2014 May 06; 19(5):810-20. PMID: 24709624.
    Citations: 196     Fields:    Translation:AnimalsCells
  36. Rosen ED, Spiegelman BM. What we talk about when we talk about fat. Cell. 2014 Jan 16; 156(1-2):20-44. PMID: 24439368.
    Citations: 819     Fields:    Translation:HumansAnimalsCells
  37. Kang S, Kong X, Rosen ED. Adipocyte-specific transgenic and knockout models. Methods Enzymol. 2014; 537:1-16. PMID: 24480338.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  38. Griffin MJ, Zhou Y, Kang S, Zhang X, Mikkelsen TS, Rosen ED. Early B-cell factor-1 (EBF1) is a key regulator of metabolic and inflammatory signaling pathways in mature adipocytes. J Biol Chem. 2013 Dec 13; 288(50):35925-39. PMID: 24174531.
    Citations: 20     Fields:    Translation:AnimalsCells
  39. Bozec A, Bakiri L, Jimenez M, Rosen ED, Catalá-Lehnen P, Schinke T, Schett G, Amling M, Wagner EF. Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolism. J Cell Sci. 2013 Dec 01; 126(Pt 23):5432-40. PMID: 24046454.
    Citations: 23     Fields:    Translation:AnimalsCells
  40. Ziller MJ, Gu H, Müller F, Donaghey J, Tsai LT, Kohlbacher O, De Jager PL, Rosen ED, Bennett DA, Bernstein BE, Gnirke A, Meissner A. Charting a dynamic DNA methylation landscape of the human genome. Nature. 2013 Aug 22; 500(7463):477-81. PMID: 23925113; PMCID: PMC3821869.
    Citations: 610     Fields:    Translation:HumansCells
  41. Eguchi J, Kong X, Tenta M, Wang X, Kang S, Rosen ED. Interferon regulatory factor 4 regulates obesity-induced inflammation through regulation of adipose tissue macrophage polarization. Diabetes. 2013 Oct; 62(10):3394-403. PMID: 23835343; PMCID: PMC3781469.
    Citations: 54     Fields:    Translation:AnimalsCells
  42. Kiviranta R, Yamana K, Saito H, Ho DK, Laine J, Tarkkonen K, Nieminen-Pihala V, Hesse E, Correa D, Määttä J, Tessarollo L, Rosen ED, Horne WC, Jenkins NA, Copeland NG, Warming S, Baron R. Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages. J Exp Med. 2013 May 06; 210(5):969-85. PMID: 23569325.
    Citations: 27     Fields:    Translation:AnimalsCells
  43. Lee KY, Russell SJ, Ussar S, Boucher J, Vernochet C, Mori MA, Smyth G, Rourk M, Cederquist C, Rosen ED, Kahn BB, Kahn CR. Lessons on conditional gene targeting in mouse adipose tissue. Diabetes. 2013 Mar; 62(3):864-74. PMID: 23321074; PMCID: PMC3581196.
    Citations: 178     Fields:    Translation:AnimalsCells
  44. Kang S, Akerblad P, Kiviranta R, Gupta RK, Kajimura S, Griffin MJ, Min J, Baron R, Rosen ED. Regulation of early adipose commitment by Zfp521. PLoS Biol. 2012; 10(11):e1001433. PMID: 23209378.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  45. Wrann CD, Rosen ED. New insights into adipocyte-specific leptin gene expression. Adipocyte. 2012 Jul 01; 1(3):168-172. PMID: 23700528.
    Citations: 15     Fields:    
  46. Wrann CD, Eguchi J, Bozec A, Xu Z, Mikkelsen T, Gimble J, Nave H, Wagner EF, Ong SE, Rosen ED. FOSL2 promotes leptin gene expression in human and mouse adipocytes. J Clin Invest. 2012 Mar; 122(3):1010-21. PMID: 22326952; PMCID: PMC3322535.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  47. Gupta RK, Rosen ED, Spiegelman BM. Identifying novel transcriptional components controlling energy metabolism. Cell Metab. 2011 Dec 07; 14(6):739-45. PMID: 22152302.
    Citations: 10     Fields:    
  48. Jun LS, Siddall CP, Rosen ED. A minor role for lipocalin 2 in high-fat diet-induced glucose intolerance. Am J Physiol Endocrinol Metab. 2011 Nov; 301(5):E825-35. PMID: 21771968.
    Citations: 31     Fields:    Translation:Animals
  49. Eguchi J, Wang X, Yu S, Kershaw EE, Chiu PC, Dushay J, Estall JL, Klein U, Maratos-Flier E, Rosen ED. Transcriptional control of adipose lipid handling by IRF4. Cell Metab. 2011 Mar 02; 13(3):249-59. PMID: 21356515.
    Citations: 291     Fields:    Translation:AnimalsCells
  50. Bock J, Fukuyo Y, Kang S, Phipps ML, Alexandrov LB, Rasmussen KØ, Bishop AR, Rosen ED, Martinez JS, Chen HT, Rodriguez G, Alexandrov BS, Usheva A. Mammalian stem cells reprogramming in response to terahertz radiation. PLoS One. 2010 Dec 31; 5(12):e15806. PMID: 21209821.
    Citations: 29     Fields:    Translation:AnimalsCells
  51. Mikkelsen TS, Xu Z, Zhang X, Wang L, Gimble JM, Lander ES, Rosen ED. Comparative epigenomic analysis of murine and human adipogenesis. Cell. 2010 Oct 01; 143(1):156-69. PMID: 20887899.
    Citations: 303     Fields:    Translation:HumansAnimalsCells
  52. Rosen E, Eguchi J, Xu Z. Transcriptional targets in adipocyte biology. Expert Opin Ther Targets. 2009 Aug; 13(8):975-86. PMID: 19534570.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  53. Xu Z, Yu S, Hsu CH, Eguchi J, Rosen ED. The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2421-6. PMID: 18250317.
    Citations: 61     Fields:    Translation:AnimalsCells
  54. Eguchi J, Yan QW, Schones DE, Kamal M, Hsu CH, Zhang MQ, Crawford GE, Rosen ED. Interferon regulatory factors are transcriptional regulators of adipogenesis. Cell Metab. 2008 Jan; 7(1):86-94. PMID: 18177728; PMCID: PMC2278019.
    Citations: 70     Fields:    Translation:AnimalsCells
  55. Yan QW, Yang Q, Mody N, Graham TE, Hsu CH, Xu Z, Houstis NE, Kahn BB, Rosen ED. The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes. 2007 Oct; 56(10):2533-40. PMID: 17639021.
    Citations: 186     Fields:    Translation:AnimalsCells
  56. Mukherjee A, Sidis Y, Mahan A, Raher MJ, Xia Y, Rosen ED, Bloch KD, Thomas MK, Schneyer AL. FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1348-53. PMID: 17229845; PMCID: PMC1783105.
    Citations: 77     Fields:    Translation:HumansAnimals
  57. Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature. 2006 Dec 14; 444(7121):847-53. PMID: 17167472.
    Citations: 753     Fields:    Translation:HumansAnimalsCells
  58. Rosen ED, MacDougald OA. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol. 2006 Dec; 7(12):885-96. PMID: 17139329.
    Citations: 988     Fields:    Translation:HumansAnimalsCells
  59. Jimenez MA, Akerblad P, Sigvardsson M, Rosen ED. Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade. Mol Cell Biol. 2007 Jan; 27(2):743-57. PMID: 17060461; PMCID: PMC1800806.
    Citations: 109     Fields:    Translation:AnimalsCells
  60. Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature. 2006 Apr 13; 440(7086):944-8. PMID: 16612386.
    Citations: 818     Fields:    Translation:AnimalsCells
  61. Sastre M, Dewachter I, Rossner S, Bogdanovic N, Rosen E, Borghgraef P, Evert BO, Dumitrescu-Ozimek L, Thal DR, Landreth G, Walter J, Klockgether T, van Leuven F, Heneka MT. Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proc Natl Acad Sci U S A. 2006 Jan 10; 103(2):443-8. PMID: 16407166; PMCID: PMC1326151.
    Citations: 151     Fields:    Translation:HumansAnimalsCells
  62. Rosen ED. New drugs from fat bugs? Cell Metab. 2006 Jan; 3(1):1-2. PMID: 16399497.
    Citations: 3     Fields:    Translation:AnimalsCells
  63. Rosen ED. The transcriptional basis of adipocyte development. Prostaglandins Leukot Essent Fatty Acids. 2005 Jul; 73(1):31-4. PMID: 15936931.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  64. Costa-Guda J, Rosen ED, Jensen RT, Chung DC, Arnold A. Mutational analysis of PPARG as a candidate tumour suppressor gene in enteropancreatic endocrine tumours. Clin Endocrinol (Oxf). 2005 May; 62(5):603-6. PMID: 15853832.
    Citations: 1     Fields:    Translation:HumansCells
  65. Xie J, Zhu H, Larade K, Ladoux A, Seguritan A, Chu M, Ito S, Bronson RT, Leiter EH, Zhang CY, Rosen ED, Bunn HF. Absence of a reductase, NCB5OR, causes insulin-deficient diabetes. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10750-5. PMID: 15247412; PMCID: PMC490006.
    Citations: 26     Fields:    Translation:HumansAnimals
  66. Mix KS, Coon CI, Rosen ED, Suh N, Sporn MB, Brinckerhoff CE. Peroxisome proliferator-activated receptor-gamma-independent repression of collagenase gene expression by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and prostaglandin 15-deoxy-delta(12,14) J2: a role for Smad signaling. Mol Pharmacol. 2004 Feb; 65(2):309-18. PMID: 14742672.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  67. Rosen ED. Energy balance: a new role for PPARalpha. Curr Biol. 2003 Dec 16; 13(24):R961-3. PMID: 14680654.
    Citations: 3     Fields:    Translation:Humans
  68. Rosen ED, Kulkarni RN, Sarraf P, Ozcan U, Okada T, Hsu CH, Eisenman D, Magnuson MA, Gonzalez FJ, Kahn CR, Spiegelman BM. Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol. 2003 Oct; 23(20):7222-9. PMID: 14517292.
    Citations: 69     Fields:    Translation:Animals
  69. Norris AW, Chen L, Fisher SJ, Szanto I, Ristow M, Jozsi AC, Hirshman MF, Rosen ED, Goodyear LJ, Gonzalez FJ, Spiegelman BM, Kahn CR. Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest. 2003 Aug; 112(4):608-18. PMID: 12925701; PMCID: PMC171387.
    Citations: 156     Fields:    Translation:Animals
  70. Place AE, Suh N, Williams CR, Risingsong R, Honda T, Honda Y, Gribble GW, Leesnitzer LM, Stimmel JB, Willson TM, Rosen E, Sporn MB. The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo. Clin Cancer Res. 2003 Jul; 9(7):2798-806. PMID: 12855660.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  71. Rosen ED, Cornelissen I, Liang Z, Zollman A, Casad M, Roahrig J, Suckow M, Castellino FJ. In utero transplantation of wild-type fetal liver cells rescues factor X-deficient mice from fatal neonatal bleeding diatheses. J Thromb Haemost. 2003 Jan; 1(1):19-27. PMID: 12871535.
    Citations: 3     Fields:    Translation:AnimalsCells
  72. Rosen ED. The molecular control of adipogenesis, with special reference to lymphatic pathology. Ann N Y Acad Sci. 2002 Dec; 979:143-58; discussion 188-96. PMID: 12543724.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  73. Mueller E, Drori S, Aiyer A, Yie J, Sarraf P, Chen H, Hauser S, Rosen ED, Ge K, Roeder RG, Spiegelman BM. Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms. J Biol Chem. 2002 Nov 01; 277(44):41925-30. PMID: 12200443.
    Citations: 73     Fields:    Translation:AnimalsCells
  74. Rosen ED. Molecular mechanisms of adipocyte differentiation. Ann Endocrinol (Paris). 2002 Apr; 63(2 Pt 1):79-82. PMID: 11994665.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  75. Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ, Spiegelman BM. C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev. 2002 Jan 01; 16(1):22-6. PMID: 11782441; PMCID: PMC155311.
    Citations: 471     Fields:    Translation:AnimalsCells
  76. Rosen ED, Spiegelman BM. PPARgamma : a nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem. 2001 Oct 12; 276(41):37731-4. PMID: 11459852.
    Citations: 391     Fields:    Translation:Animals
  77. Chan JC, Ganopolsky JG, Cornelissen I, Suckow MA, Sandoval-Cooper MJ, Brown EC, Noria F, Gailani D, Rosen ED, Ploplis VA, Castellino FJ. The characterization of mice with a targeted combined deficiency of protein c and factor XI. Am J Pathol. 2001 Feb; 158(2):469-79. PMID: 11159184; PMCID: PMC1850297.
    Citations: 9     Fields:    Translation:Animals
  78. Wilberding JA, Ploplis VA, McLennan L, Liang Z, Cornelissen I, Feldman M, Deford ME, Rosen ED, Castellino FJ. Development of pulmonary fibrosis in fibrinogen-deficient mice. Ann N Y Acad Sci. 2001; 936:542-8. PMID: 11460513.
    Citations: 16     Fields:    Translation:Animals
  79. Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altshuler D, Milstone DS, Mortensen RM, Spiegelman BM, Freeman MW. The role of PPAR-gamma in macrophage differentiation and cholesterol uptake. Nat Med. 2001 Jan; 7(1):41-7. PMID: 11135614.
    Citations: 132     Fields:    Translation:AnimalsCells
  80. Ploplis VA, Wilberding J, McLennan L, Liang Z, Cornelissen I, DeFord ME, Rosen ED, Castellino FJ. A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice. Am J Pathol. 2000 Sep; 157(3):703-8. PMID: 10980108; PMCID: PMC1885710.
    Citations: 35     Fields:    Translation:Animals
  81. Rosen ED, Spiegelman BM. Peroxisome proliferator-activated receptor gamma ligands and atherosclerosis: ending the heartache. J Clin Invest. 2000 Sep; 106(5):629-31. PMID: 10974014; PMCID: PMC381292.
    Citations: 12     Fields:    
  82. Yoon JC, Chickering TW, Rosen ED, Dussault B, Qin Y, Soukas A, Friedman JM, Holmes WE, Spiegelman BM. Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. Mol Cell Biol. 2000 Jul; 20(14):5343-9. PMID: 10866690; PMCID: PMC85983.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  83. Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM. Transcriptional regulation of adipogenesis. Genes Dev. 2000 Jun 01; 14(11):1293-307. PMID: 10837022.
    Citations: 570     Fields:    Translation:HumansAnimalsCells
  84. Dewerchin M, Liang Z, Moons L, Carmeliet P, Castellino FJ, Collen D, Rosen ED. Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice. Thromb Haemost. 2000 Feb; 83(2):185-90. PMID: 10739370.
    Citations: 37     Fields:    Translation:Animals
  85. Rosen ED, Spiegelman BM. Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol. 2000; 16:145-71. PMID: 11031233.
    Citations: 348     Fields:    Translation:HumansAnimalsCells
  86. Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS, Spiegelman BM, Mortensen RM. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell. 1999 Oct; 4(4):611-7. PMID: 10549292.
    Citations: 662     Fields:    Translation:AnimalsCells
  87. Chan JC, Carmeliet P, Moons L, Rosen ED, Huang ZF, Broze GJ, Collen D, Castellino FJ. Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit. J Clin Invest. 1999 Feb; 103(4):475-82. PMID: 10021455; PMCID: PMC408108.
    Citations: 16     Fields:    Translation:Animals
  88. Wu Z, Rosen ED, Brun R, Hauser S, Adelmant G, Troy AE, McKeon C, Darlington GJ, Spiegelman BM. Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol Cell. 1999 Feb; 3(2):151-8. PMID: 10078198.
    Citations: 343     Fields:    Translation:AnimalsCells
  89. Jalbert LR, Rosen ED, Moons L, Chan JC, Carmeliet P, Collen D, Castellino FJ. Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice. J Clin Invest. 1998 Oct 15; 102(8):1481-8. PMID: 9788960; PMCID: PMC508997.
    Citations: 50     Fields:    Translation:Animals
  90. Stauffer DR, Chukwumezie BN, Wilberding JA, Rosen ED, Castellino FJ. Characterization of transcriptional regulatory elements in the promoter region of the murine blood coagulation factor VII gene. J Biol Chem. 1998 Jan 23; 273(4):2277-87. PMID: 9442072.
    Citations: 5     Fields:    Translation:AnimalsCells
  91. Rosen ED, Beninghof EG, Koenig RJ. Dimerization interfaces of thyroid hormone, retinoic acid, vitamin D, and retinoid X receptors. J Biol Chem. 1993 Jun 05; 268(16):11534-41. PMID: 8389356.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  92. Rosen ED, O'Donnell AL, Koenig RJ. Ligand-dependent synergy of thyroid hormone and retinoid X receptors. J Biol Chem. 1992 Nov 05; 267(31):22010-3. PMID: 1331043.
    Citations: 13     Fields:    Translation:AnimalsCells
  93. Rosen ED, O'Donnell AL, Koenig RJ. Protein-protein interactions involving erbA superfamily receptors: through the TRAPdoor. Mol Cell Endocrinol. 1991 Jun; 78(1-2):C83-8. PMID: 1682188.
    Citations: 4     Fields:    Translation:Cells
  94. Binienda Z, Rosen ED, Kelleman A, Sadowsky DW, Nathanielsz PW, Mitchell MD. Maintaining fetal normoglycemia prevents the increase in myometrial activity and uterine 13,14-dihydro-15-keto-prostaglandin F2 alpha production during food withdrawal in late pregnancy in the ewe. Endocrinology. 1990 Dec; 127(6):3047-51. PMID: 2174342.
    Citations: 1     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.