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Nicanor Tercero Obaldia Rodriguez

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Biography
Harvard School of Public Health, Boston, MADSc2013Immunology and Infectious Diseases, Public Health
University of Wisconsin-Madison, Madison, WIMS1985Veterinary Science
Universidad Nacional de Colombia-Bogota, Bogota, ColombiaDVM1981Veterinary Medicine
2015
FASTMH (Fellow ASTMH)
2010
Gorgas Memorial Gold Medal

Overview
Malaria remains a major cause of morbidity and mortality around the world, nevertheless little is known about antimalarial drugs modes of action and resistance patterns of the parasite. The objective of our work is to test the pharmacokinetics and efficacy of new antimalarial compounds, the molecular mechanisms of drug resistance and pathogenesis of the parasite, as well as, to test the immunogenicity and efficacy of antimalarial vaccines.

Dr. Obaldia's research has focused on studying the efficacy and pharmacokinetics of new antimalarial compounds, the molecular mechanisms of drug resistance, the pathogenesis of the disease, and the immunogenicity and efficacy of experimental antimalarial vaccines. The approach taken by Dr. Obaldia's laboratory to study these problems has been the study of the efficacy of new antimalarial compounds against resistant multiple Plasmodium falciparum and vivax strains adapted to grow in vitro and in vivo in the Aotus / P. falciparum animal model, which has made it possible to study the efficacy of multiple classes of antimalarial compounds including derivatives of the Chinese drug Qinhao (artemisinin).

In another aspect of his research, he has studied the efficacy and immunogenicity of antimalarial vaccines based on recombinant Adenovirus and DNA plasmid peptides in the Aotus erythrocyte challenge model. Recently, he has participated in studies on the molecular epidemiology of malaria in Panama and in a consortium with Harvard and the University of South Florida funded by the Bill & Melinda Gates Foundation that tries to keep Plasmodium vivax adapted to non-human primates and in continuous culture.

He has also recently carried out studies on the molecular epidemiology and population genetics of Plasmodium falciparum and vivax in Meso America and Panama, and as a veterinarian in the past done studies on the epidemiology, diagnosis, and control of animal diseases, including but not limited to Bluetongue virus of sheep and cattle, rabies transmitted by bats, Eastern Equine Encephalitis (EEE), pseudorabies and parvovirus in pigs and Tuberculosis.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. PFID-FID- 2021-094 (Nicanor Obaldia III) Jan 17, 2022 - Jan 31, 2024
    National Secretary of Science Technology and Innovation of Panama (SENACYT)
    Preclinical evaluation of a whole organism blood stage vaccine against experimental infection with Plasmodium vivax in the Aotus model
    Role Description: The objective of this proposal is to evaluate the immunogenicity and protective efficacy of a whole organism blood-stage vaccine of P. vivax in the Aotus model
    Role: Principal Investigator
  2. COVID19- 041 (Nicanor Obaldia III) Jan 4, 2021 - Jan 31, 2023
    National Secretary of Science Technology and Innovation of Panama (SENACYT)
    In vitro efficacy of antimalarial drugs against SARS-CoV-2 variants circulating in Panama
    Role Description: To screen selected antiparasitic compounds against circulating SARS-CoV-2 variants in Panama
    Role: Principal Investigator
  3. FID16-097 (Nicanor Obaldia III) Aug 1, 2018 - Mar 31, 2020
    National Secretary of Science Technology and Innovation of Panama (SENACYT)
    Genetic diversity and population structure of malaria parasites from Panama
    Role Description: To characterize the genetic diversity and population structure of P. vivax isolates currently circulating in Panama and determine the genetic barcode of imported or resurgent P. falciparum parasites, as well as obtain information on the population structure and transmission dynamics.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Buyon LE, Santamaria AM, Early AM, Quijada M, Barahona I, Lasso J, Avila M, Volkman SK, Marti M, Neafsey DE, Obaldia Iii N. Population genomics of Plasmodium vivax in Panama to assess the risk of case importation on malaria elimination. PLoS Negl Trop Dis. 2020 12; 14(12):e0008962. PMID: 33315861; PMCID: PMC7769613.
    Citations: 6     Fields:    Translation:HumansAnimalsPHPublic Health
  2. Obaldía N, Nuñez M. On the survival of 48 h Plasmodium vivax Aotus monkey-derived ex vivo cultures: the role of leucocytes filtration and chemically defined lipid concentrate media supplementation. Malar J. 2020 Aug 03; 19(1):278. PMID: 32746814.
    Citations: 1     Fields:    Translation:AnimalsCells
  3. McCallum FJ, Birrell GW, Chavchich M, Harris I, Obaldia N, Van Breda K, Heffernan GD, Jacobus DP, Shanks D, Edstein MD. In Vivo Efficacy and Pharmacokinetics of the 2-Aminomethylphenol Antimalarial JPC-3210 in the Aotus Monkey-Human Malaria Model. Antimicrob Agents Chemother. 2020 02 21; 64(3). PMID: 31843994.
    Citations:    Fields:    Translation:HumansAnimals
  4. Obaldia N, Milhous WK, Kyle DE. Reversal of Chloroquine Resistance of Plasmodium vivax in Aotus Monkeys. Antimicrob Agents Chemother. 2018 09; 62(9). PMID: 29941642; PMCID: PMC6125511.
    Citations: 2     Fields:    Translation:Animals
  5. Obaldía N, Nuñez M, Montilla S, Otero W, Marin JC. Tuberculosis (TB) outbreak in a closed Aotus monkey breeding colony: Epidemiology, diagnosis and TB screening using antibody and interferon-gamma release testing. Comp Immunol Microbiol Infect Dis. 2018 Jun; 58:1-10. PMID: 30245044.
    Citations: 5     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  6. Obaldia N, Meibalan E, Sa JM, Ma S, Clark MA, Mejia P, Moraes Barros RR, Otero W, Ferreira MU, Mitchell JR, Milner DA, Huttenhower C, Wirth DF, Duraisingh MT, Wellems TE, Marti M. Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection. mBio. 2018 05 08; 9(3). PMID: 29739900.
    Citations: 75     Fields:    Translation:HumansAnimals
  7. Obaldia N, Stockelman MG, Otero W, Cockrill JA, Ganeshan H, Abot EN, Zhang J, Limbach K, Charoenvit Y, Doolan DL, Tang DC, Richie TL. A Plasmodium vivax Plasmid DNA- and Adenovirus-Vectored Malaria Vaccine Encoding Blood-Stage Antigens AMA1 and MSP142 in a Prime/Boost Heterologous Immunization Regimen Partially Protects Aotus Monkeys against Blood-Stage Challenge. Clin Vaccine Immunol. 2017 Apr; 24(4). PMID: 28179404; PMCID: PMC5382831.
    Citations: 7     Fields:    Translation:Animals
  8. Shaw-Saliba K, Thomson-Luque R, Obaldía N, Nuñez M, Dutary S, Lim C, Barnes S, Kocken CH, Duraisingh MT, Adams JH, Pasini EM. Insights into an Optimization of Plasmodium vivax Sal-1 In Vitro Culture: The Aotus Primate Model. PLoS Negl Trop Dis. 2016 07; 10(7):e0004870. PMID: 27463518.
    Citations: 11     Fields:    Translation:AnimalsCells
  9. Obaldía N, Dow GS, Gerena L, Kyle D, Otero W, Mantel PY, Baro N, Daniels R, Mukherjee A, Childs LM, Buckee C, Duraisingh MT, Volkman SK, Wirth DF, Marti M. Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model. Sci Rep. 2016 Feb 16; 6:21216. PMID: 26880111.
    Citations: 1     Fields:    Translation:Animals
  10. Obaldia N. Determinants of low socio-economic status and risk of Plasmodium vivax malaria infection in Panama (2009-2012): a case-control study. Malar J. 2015 Jan 21; 14:14. PMID: 25603818; PMCID: PMC4320569.
    Citations: 11     Fields:    Translation:Humans
  11. Ohrt C, Li Q, Obaldia N, Im-Erbsin R, Xie L, Berman J. Efficacy of intravenous methylene blue, intravenous artesunate, and their combination in preclinical models of malaria. Malar J. 2014 Oct 21; 13:415. PMID: 25336091.
    Citations: 5     Fields:    Translation:Animals
  12. Obaldia N, Baro NK, Calzada JE, Santamaria AM, Daniels R, Wong W, Chang HH, Hamilton EJ, Arevalo-Herrera M, Herrera S, Wirth DF, Hartl DL, Marti M, Volkman SK. Clonal outbreak of Plasmodium falciparum infection in eastern Panama. J Infect Dis. 2015 Apr 01; 211(7):1087-96. PMID: 25336725; PMCID: PMC4366603.
    Citations: 49     Fields:    Translation:HumansAnimalsPHPublic Health
  13. Cassera MB, Hazleton KZ, Merino EF, Obaldia N, Ho MC, Murkin AS, DePinto R, Gutierrez JA, Almo SC, Evans GB, Babu YS, Schramm VL. Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model. PLoS One. 2011; 6(11):e26916. PMID: 22096507.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  14. Obaldia N, Otero W, Marin C, Aparicio J, Cisneros G. Long-term effect of a simple nest-box on the reproductive efficiency and other life traits of an Aotus lemurinus lemurinus monkey colony: an animal model for malaria research. J Med Primatol. 2011 Dec; 40(6):383-91. PMID: 21781134.
    Citations: 9     Fields:    Translation:Animals
  15. Obaldía N, Milhous W, Kyle D. Adaptation of a Thai multidrug-resistant C2A clone of Plasmodium falciparum to Aotus monkeys and its preliminary in vivo antimalarial drug efficacy-resistance profile. Am J Trop Med Hyg. 2009 Oct; 81(4):587-94. PMID: 19815871.
    Citations: 3     Fields:    Translation:Animals
  16. Obaldia N, Kotecka BM, Edstein MD, Haynes RK, Fugmann B, Kyle DE, Rieckmann KH. Evaluation of artemisone combinations in Aotus monkeys infected with Plasmodium falciparum. Antimicrob Agents Chemother. 2009 Aug; 53(8):3592-4. PMID: 19506062.
    Citations: 10     Fields:    Translation:Animals
  17. Dow GS, Chen Y, Andrews KT, Caridha D, Gerena L, Gettayacamin M, Johnson J, Li Q, Melendez V, Obaldia N, Tran TN, Kozikowski AP. Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors. Antimicrob Agents Chemother. 2008 Oct; 52(10):3467-77. PMID: 18644969.
    Citations: 30     Fields:    Translation:Animals
  18. Calzada JE, Samudio F, Bayard V, Obaldia N, de Mosca IB, Pascale JM. Revising antimalarial drug policy in Central America: experience in Panama. Trans R Soc Trop Med Hyg. 2008 Jul; 102(7):694-8. PMID: 18436272.
    Citations: 9     Fields:    Translation:HumansAnimals
  19. Obaldía N. Clinico-pathological observations on the pathogenesis of severe thrombocytopenia and anemia induced by Plasmodium vivax infections during antimalarial drug efficacy trials in Aotus monkeys. Am J Trop Med Hyg. 2007 Jul; 77(1):3-13. PMID: 17620623.
    Citations: 5     Fields:    Translation:Animals
  20. Dow GS, Heady TN, Bhattacharjee AK, Caridha D, Gerena L, Gettayacamin M, Lanteri CA, Obaldia N, Roncal N, Shearer T, Smith PL, Tungtaeng A, Wolf L, Cabezas M, Yourick D, Smith KS. Utility of alkylaminoquinolinyl methanols as new antimalarial drugs. Antimicrob Agents Chemother. 2006 Dec; 50(12):4132-43. PMID: 16966402; PMCID: PMC1694001.
    Citations: 9     Fields:    Translation:AnimalsCells
  21. Guan J, Zhang Q, O'Neil M, Obaldia N, Ager A, Gerena L, Lin AJ. Antimalarial activities of new pyrrolo[3,2-f]quinazoline-1,3-diamine derivatives. Antimicrob Agents Chemother. 2005 Dec; 49(12):4928-33. PMID: 16304154; PMCID: PMC1315943.
    Citations: 10     Fields:    Translation:Animals
  22. Samudio F, Santamaría AM, Obaldía N, Pascale JM, Bayard V, Calzada JE. Prevalence of Plasmodium falciparum mutations associated with antimalarial drug resistance during an epidemic in Kuna Yala, Panama, Central America. Am J Trop Med Hyg. 2005 Nov; 73(5):839-41. PMID: 16282290.
    Citations: 18     Fields:    Translation:HumansAnimalsPHPublic Health
  23. Obaldía N. Outbreaks of Aujeszky's disease in pigs from Panama. Trop Anim Health Prod. 2005 May; 37(4):277-83. PMID: 15934635.
    Citations: 1     Fields:    Translation:AnimalsPHPublic Health
  24. Jones TR, Stroncek DF, Gozalo AS, Obaldia N, Andersen EM, Lucas C, Narum DL, Magill AJ, Sim BK, Hoffman SL. Anemia in parasite- and recombinant protein-immunized aotus monkeys infected with Plasmodium falciparum. Am J Trop Med Hyg. 2002 Jun; 66(6):672-9. PMID: 12224573.
    Citations: 13     Fields:    Translation:AnimalsCells
  25. Jones TR, Gramzinski RA, Aguiar JC, Sim BK, Narum DL, Fuhrmann SR, Kumar S, Obaldia N, Hoffman SL. Absence of antigenic competition in Aotus monkeys immunized with Plasmodium falciparum DNA vaccines delivered as a mixture. Vaccine. 2002 Feb 22; 20(11-12):1675-80. PMID: 11858878.
    Citations: 8     Fields:    Translation:AnimalsCellsPHPublic Health
  26. Sim BK, Narum DL, Liang H, Fuhrmann SR, Obaldia N, Gramzinski R, Aguiar J, Haynes JD, Moch JK, Hoffman SL. Induction of biologically active antibodies in mice, rabbits, and monkeys by Plasmodium falciparum EBA-175 region II DNA vaccine. Mol Med. 2001 Apr; 7(4):247-54. PMID: 11471569; PMCID: PMC1950033.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  27. Jones TR, Obaldia N, Gramzinski RA, Hoffman SL. Repeated infection of Aotus monkeys with Plasmodium falciparum induces protection against subsequent challenge with homologous and heterologous strains of parasite. Am J Trop Med Hyg. 2000 Jun; 62(6):675-80. PMID: 11304053.
    Citations: 8     Fields:    Translation:HumansAnimalsPHPublic Health
  28. Jones TR, Obaldia N, Gramzinski RA, Charoenvit Y, Kolodny N, Kitov S, Davis HL, Krieg AM, Hoffman SL. Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys. Vaccine. 1999 Aug 06; 17(23-24):3065-71. PMID: 10462241.
    Citations: 29     Fields:    Translation:AnimalsCells
  29. Gramzinski RA, Obaldia N, Jones TR, Rossan RN, Collins WE, Garrett DO, Lal AA, Hoffman SL. Susceptibility of Panamanian Aotus lemurinus lemurinus to sporozoite-induced Plasmodium falciparum (Santa Lucia) infection. Am J Trop Med Hyg. 1999 Jul; 61(1):19-25. PMID: 10432049.
    Citations: 1     Fields:    Translation:AnimalsCells
  30. Gramzinski RA, Millan CL, Obaldia N, Hoffman SL, Davis HL. Immune response to a hepatitis B DNA vaccine in Aotus monkeys: a comparison of vaccine formulation, route, and method of administration. Mol Med. 1998 Feb; 4(2):109-18. PMID: 9508788; PMCID: PMC2230303.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  31. Gramzinski RA, Maris DC, Doolan D, Charoenvit Y, Obaldia N, Rossan R, Sedegah M, Wang R, Hobart P, Margalith M, Hoffman S. Malaria DNA vaccines in Aotus monkeys. Vaccine. 1997 Jun; 15(8):913-5. PMID: 9234546.
    Citations: 8     Fields:    Translation:Animals
  32. Obaldia N, Rossan RN, Cooper RD, Kyle DE, Nuzum EO, Rieckmann KH, Shanks GD. WR 238605, chloroquine, and their combinations as blood schizonticides against a chloroquine-resistant strain of Plasmodium vivax in Aotus monkeys. Am J Trop Med Hyg. 1997 May; 56(5):508-10. PMID: 9180599.
    Citations: 14     Fields:    Translation:Animals
  33. Obaldia N. Outbreaks of porcine parvovirus disease in Panama. Trop Anim Health Prod. 1991 Aug; 23(3):181-5. PMID: 1662424.
    Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
  34. Obaldia N. Detection of Klebsiella pneumoniae antibodies in Aotus l. lemurinus (Panamanian owl monkey) using an enzyme linked immunosorbent assay (ELISA) test. Lab Anim. 1991 Apr; 25(2):133-41. PMID: 1857095.
    Citations: 7     Fields:    Translation:AnimalsCells
  35. Obaldia N, Hanson RP. Effect of Newcastle disease virus on ocular and paraocular tissues in experimentally inoculated chickens. Avian Dis. 1989 Apr-Jun; 33(2):285-90. PMID: 2751562.
    Citations:    Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.