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profileSteven Edward Hyman, M.D.

TitleProfessor of Stem Cell and Regenerative Biology
InstitutionFaculty of Arts & Sciences
DepartmentStem Cell and Regenerative Biology
AddressHarvard Stem Cell Center
Sherman Fairchild Biochemistry Bldg
7 Divinity Ave
Cambridge MA 02138
Phone617/495-8832
Fax617/714-8957
vCardDownload vCard (login for email)

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Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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S07RR018170     (HYMAN, STEVEN E)Sep 1, 2002 - Aug 31, 2006
NIH/NCRR
Enhancement of Human Subject Protection Training
Role: Principal Investigator
P01DA010160     (GOLDMAN-RAKIC, PATRICIA S)Sep 30, 1995 - Aug 31, 2001
NIH/NIDA
CHOLINERGIC AND DOPAMINERGIC SYSTEMS IN THE BRAIN AND MULTIPLE INTERACTIONS
Role: Co-Principal Investigator
K02DA000257     (HYMAN, STEVEN E)Aug 1, 1995 - Apr 13, 1996
NIH/NIDA
MOLECULAR PLASTICITY TO DRUGS OF ABUSE
Role: Principal Investigator
P01DA009467     (ROSEN, BRUCE R)Sep 30, 1994 - Jun 30, 2005
NIH/NIDA
FUNCTIONAL BRAIN MAPPING OF COCAINE ACTION
Role: Co-Principal Investigator
H13SP005874     (HYMAN, STEVEN E)Feb 1, 1993 - Jan 31, 1994
SAMHSA/CSAP
COMNTY PART CONF 'ADDICTION: FROM MOLECULES TO POLICY'
Role: Principal Investigator

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hyman S. Biology needs more staff scientists. Nature. 2017 05 16; 545(7654):283-284. PMID: 28516936.
    View in: PubMed
  2. Hyman SE. A Valuable New Direction in Ethical Analysis of Psychiatric Genetics. Am J Bioeth. 2017 Apr; 17(4):13-15. PMID: 28328368.
    View in: PubMed
  3. Hyman SE. A New Hope for Biological Insights Into Depression. Biol Psychiatry. 2017 Feb 15; 81(4):280-281. PMID: 28089024.
    View in: PubMed
  4. Ransom RC, Hunter DJ, Hyman S, Singh G, Ransom SC, Shen EZ, Perez KC, Gillette M, Li J, Liu B, Brunski JB, Helms JA. Axin2-expressing cells execute regeneration after skeletal injury. Sci Rep. 2016 Nov 17; 6:36524. PMID: 27853243.
    View in: PubMed
  5. Hyman SE. Back to basics: luring industry back into neuroscience. Nat Neurosci. 2016 Oct 26; 19(11):1383-1384. PMID: 27786185.
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  6. Hyman SE, Landis SC, Leshner AI. Research Into Brain Disorders as an Example of Targeted Science. JAMA. 2016 Oct 25; 316(16):1673-1674. PMID: 27668392.
    View in: PubMed
  7. Robinson EB, Neale BM, Hyman SE. Genetic research in autism spectrum disorders. Curr Opin Pediatr. 2015 Dec; 27(6):685-91. PMID: 26371945; PMCID: PMC4650984.
    View in: PubMed, PubMed Central
  8. Hyman SE. Enlisting hESCs to Interrogate Genetic Variants Associated with Neuropsychiatric Disorders. Cell Stem Cell. 2015 Sep 03; 17(3):253-4. PMID: 26340523.
    View in: PubMed
  9. Hyman SE, Goldberg ME. Protect researchers from harassment. Science. 2015 Jun 12; 348(6240):1216-7. PMID: 26068840.
    View in: PubMed
  10. Hyman S. Mental health: depression needs large human-genetics studies. Nature. 2014 Nov 13; 515(7526):189-91. PMID: 25391945.
    View in: PubMed
  11. Choi DW, Armitage R, Brady LS, Coetzee T, Fisher W, Hyman S, Pande A, Paul S, Potter W, Roin B, Sherer T. Medicines for the mind: policy-based "pull" incentives for creating breakthrough CNS drugs. Neuron. 2014 Nov 05; 84(3):554-63. PMID: 25442934.
    View in: PubMed
  12. Pankevich DE, Altevogt BM, Dunlop J, Gage FH, Hyman SE. Improving and accelerating drug development for nervous system disorders. Neuron. 2014 Nov 05; 84(3):546-53. PMID: 25442933; PMCID: PMC4254615.
    View in: PubMed, PubMed Central
  13. Hyman SE. The unconscionable gap between what we know and what we do. Sci Transl Med. 2014 Sep 10; 6(253):253cm9. PMID: 25210058.
    View in: PubMed
  14. Hyman SE. How far can mice carry autism research? Cell. 2014 Jul 03; 158(1):13-4. PMID: 24995974.
    View in: PubMed
  15. McCarroll SA, Feng G, Hyman SE. Genome-scale neurogenetics: methodology and meaning. Nat Neurosci. 2014 Jun; 17(6):756-63. PMID: 24866041; PMCID: PMC4912829.
    View in: PubMed, PubMed Central
  16. Hyman SE. Perspective: Revealing molecular secrets. Nature. 2014 Apr 03; 508(7494):S20. PMID: 24695333.
    View in: PubMed
  17. Hyman SE. Time for new schizophrenia Rx. Science. 2014 Mar 14; 343(6176):1177. PMID: 24626901.
    View in: PubMed
  18. Hyman SE. Revitalizing psychiatric therapeutics. Neuropsychopharmacology. 2014 Jan; 39(1):220-9. PMID: 24317307; PMCID: PMC3857646.
    View in: PubMed, PubMed Central
  19. Casey BJ, Craddock N, Cuthbert BN, Hyman SE, Lee FS, Ressler KJ. DSM-5 and RDoC: progress in psychiatry research? Nat Rev Neurosci. 2013 Nov; 14(11):810-4. PMID: 24135697; PMCID: PMC4372467.
    View in: PubMed, PubMed Central
  20. McCarroll SA, Hyman SE. Progress in the genetics of polygenic brain disorders: significant new challenges for neurobiology. Neuron. 2013 Oct 30; 80(3):578-87. PMID: 24183011; PMCID: PMC4066986.
    View in: PubMed, PubMed Central
  21. Hyman SE. Revolution stalled. Sci Transl Med. 2012 Oct 10; 4(155):155cm11. PMID: 23052291.
    View in: PubMed
  22. Hyman SE. Might stimulant drugs support moral agency in ADHD children? J Med Ethics. 2013 Jun; 39(6):369-70; discussion 372-3. PMID: 23001921; PMCID: PMC3664373.
    View in: PubMed, PubMed Central
  23. Hyman SE. Target practice: HDAC inhibitors for schizophrenia. Nat Neurosci. 2012 Sep; 15(9):1180-1. PMID: 22929911.
    View in: PubMed
  24. Collins PY, Patel V, Joestl SS, March D, Insel TR, Daar AS, Anderson W, Dhansay MA, Phillips A, Shurin S, Walport M, Ewart W, Savill SJ, Bordin IA, Costello EJ, Durkin M, Fairburn C, Glass RI, Hall W, Huang Y, Hyman SE, Jamison K, Kaaya S, Kapur S, Kleinman A, Ogunniyi A, Otero-Ojeda A, Poo MM, Ravindranath V, Sahakian BJ, Saxena S, Singer PA, Stein DJ. Grand challenges in global mental health. Nature. 2011 Jul 06; 475(7354):27-30. PMID: 21734685; PMCID: PMC3173804.
    View in: PubMed, PubMed Central
  25. Hyman SE. Commentary: Repairing a plane while it is flying--reflections on Rutter (2011). J Child Psychol Psychiatry. 2011 Jun; 52(6):661-2; discussion 673-5. PMID: 21434920.
    View in: PubMed
  26. Hyman SE. Genome-sequencing anniversary. The meaning of the Human Genome Project for neuropsychiatric disorders. Science. 2011 Feb 25; 331(6020):1026. PMID: 21350167.
    View in: PubMed
  27. Hyman SE. Cognitive enhancement: promises and perils. Neuron. 2011 Feb 24; 69(4):595-8. PMID: 21338872.
    View in: PubMed
  28. Hyman SE. Grouping diagnoses of mental disorders by their common risk factors. Am J Psychiatry. 2011 Jan; 168(1):1-3. PMID: 21205810.
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  29. Hyman SE. Emerging neurotechnologies for lie-detection: where are we now? An appraisal of Wolpe, Foster and Langleben's "Emerging neurotechnologies for lie-detection: promise and perils" five years later. Am J Bioeth. 2010 Oct; 10(10):49-50. PMID: 20945267.
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  30. Nestler EJ, Hyman SE. Animal models of neuropsychiatric disorders. Nat Neurosci. 2010 Oct; 13(10):1161-9. PMID: 20877280; PMCID: PMC3750731.
    View in: PubMed, PubMed Central
  31. Hyman SE. A bone to pick with compulsive behavior. Cell. 2010 May 28; 141(5):752-4. PMID: 20510922.
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  32. Hyman SE. The diagnosis of mental disorders: the problem of reification. Annu Rev Clin Psychol. 2010; 6:155-79. PMID: 17716032.
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  33. Andrews G, Goldberg DP, Krueger RF, Carpenter WT, Hyman SE, Sachdev P, Pine DS. Exploring the feasibility of a meta-structure for DSM-V and ICD-11: could it improve utility and validity? Psychol Med. 2009 Dec; 39(12):1993-2000. PMID: 19796425.
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  34. Hyman SE. How adversity gets under the skin. Nat Neurosci. 2009 Mar; 12(3):241-3. PMID: 19238182.
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  35. Hyman SE. A glimmer of light for neuropsychiatric disorders. Nature. 2008 Oct 16; 455(7215):890-3. PMID: 18923510.
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  36. Hyman SE. How might cocaine interfere with brain development? PLoS Med. 2008 Jun 10; 5(6):e130. PMID: 18547140; PMCID: PMC2429955.
    View in: PubMed, PubMed Central
  37. Hyman SE, Ivleva E. Cognition in schizophrenia. Am J Psychiatry. 2008 Mar; 165(3):312. PMID: 18316429.
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  38. Paletzki RF, Myakishev MV, Polesskaya O, Orosz A, Hyman SE, Vinson C. Inhibiting activator protein-1 activity alters cocaine-induced gene expression and potentiates sensitization. Neuroscience. 2008 Apr 09; 152(4):1040-53. PMID: 18355967; PMCID: PMC2585517.
    View in: PubMed, PubMed Central
  39. Hyman SE. How mice cope with stressful social situations. Cell. 2007 Oct 19; 131(2):232-4. PMID: 17956724.
    View in: PubMed
  40. Hyman SE. Can neuroscience be integrated into the DSM-V? Nat Rev Neurosci. 2007 Sep; 8(9):725-32. PMID: 17704814.
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  41. Hyman SE. Neuroscience: obsessed with grooming. Nature. 2007 Aug 23; 448(7156):871-2. PMID: 17713517.
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  42. Hyman SE, Insel TR. Public health contributions. Schizophr Bull. 2007 Sep; 33(5):1151-2. PMID: 17631617; PMCID: PMC2632356.
    View in: PubMed, PubMed Central
  43. Hyman SE. The neurobiology of addiction: implications for voluntary control of behavior. Am J Bioeth. 2007 Jan; 7(1):8-11. PMID: 17366151.
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  44. Moldin SO, Rubenstein JL, Hyman SE. Can autism speak to neuroscience? J Neurosci. 2006 Jun 28; 26(26):6893-6. PMID: 16807319.
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  45. Hyman SE. Even chromatin gets the blues. Nat Neurosci. 2006 Apr; 9(4):465-6. PMID: 16568101.
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  46. Sgambato-Faure V, Xiong Y, Berke JD, Hyman SE, Strehler EE. The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump. Biochem Biophys Res Commun. 2006 May 05; 343(2):630-7. PMID: 16554037; PMCID: PMC3873836.
    View in: PubMed, PubMed Central
  47. Hyman SE, Malenka RC, Nestler EJ. Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci. 2006; 29:565-98. PMID: 16776597.
    View in: PubMed
  48. Yehuda R, Hyman SE. The impact of terrorism on brain, and behavior: what we know and what we need to know. Neuropsychopharmacology. 2005 Oct; 30(10):1773-80. PMID: 16012534.
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  49. Hyman SE. Addiction: a disease of learning and memory. Am J Psychiatry. 2005 Aug; 162(8):1414-22. PMID: 16055762.
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  50. Voulalas PJ, Holtzclaw L, Wolstenholme J, Russell JT, Hyman SE. Metabotropic glutamate receptors and dopamine receptors cooperate to enhance extracellular signal-regulated kinase phosphorylation in striatal neurons. J Neurosci. 2005 Apr 13; 25(15):3763-73. PMID: 15829628.
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  51. Hyman SE. Neurotransmitters. Curr Biol. 2005 Mar 08; 15(5):R154-8. PMID: 15753022.
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  52. Makris N, Gasic GP, Seidman LJ, Goldstein JM, Gastfriend DR, Elman I, Albaugh MD, Hodge SM, Ziegler DA, Sheahan FS, Caviness VS, Tsuang MT, Kennedy DN, Hyman SE, Rosen BR, Breiter HC. Decreased absolute amygdala volume in cocaine addicts. Neuron. 2004 Nov 18; 44(4):729-40. PMID: 15541319.
    View in: PubMed
  53. Montague PR, Hyman SE, Cohen JD. Computational roles for dopamine in behavioural control. Nature. 2004 Oct 14; 431(7010):760-7. PMID: 15483596.
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  54. Hyman SE. Introduction: the brain's special status. Cerebrum. 2004; 6(4):9-12. PMID: 15986528.
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  55. Hyman SE. Methylphenidate-induced plasticity: what should we be looking for? Biol Psychiatry. 2003 Dec 15; 54(12):1310-1. PMID: 14675793.
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  56. Hyman SE. Diagnosing disorders. Sci Am. 2003 Sep; 289(3):96-103. PMID: 12951833.
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  57. Sgambato V, Minassian R, Nairn AC, Hyman SE. Regulation of ania-6 splice variants by distinct signaling pathways in striatal neurons. J Neurochem. 2003 Jul; 86(1):153-64. PMID: 12807435.
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  58. Hyman SE, Fenton WS. Medicine. What are the right targets for psychopharmacology? Science. 2003 Jan 17; 299(5605):350-1. PMID: 12532001.
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  59. Kupfer DJ, Hyman SE, Schatzberg AF, Pincus HA, Reynolds CF. Recruiting and retaining future generations of physician scientists in mental health. Arch Gen Psychiatry. 2002 Jul; 59(7):657-60. PMID: 12090819.
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  60. Hyman SE. A new beginning for research on borderline personality disorder. Biol Psychiatry. 2002 Jun 15; 51(12):933-5. PMID: 12062876.
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  61. Hyman SE. Neuroscience, genetics, and the future of psychiatric diagnosis. Psychopathology. 2002 Mar-Jun; 35(2-3):139-44. PMID: 12145499.
    View in: PubMed
  62. Hyman SE. Managing emotional fallout. Parting remarks from America's top psychiatrist. Interview by Diane Coutu. Harv Bus Rev. 2002 Feb; 80(2):55-60, 127. PMID: 11894678.
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  63. Cowan WM, Kopnisky KL, Hyman SE. The human genome project and its impact on psychiatry. Annu Rev Neurosci. 2002; 25:1-50. PMID: 12052903.
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  64. Lo B, Albert MS, Hyman S, Parens E, Wolpe PR, Mobley W. Ethics and the practice of brain science. Cerebrum. 2002; 4(3):64-6. PMID: 16619416.
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  65. Kopnisky KL, Cowan WM, Hyman SE. Levels of analysis in psychiatric research. Dev Psychopathol. 2002; 14(3):437-61. PMID: 12349868.
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  66. Hyman SE. A 28-year-old man addicted to cocaine. JAMA. 2001 Nov 28; 286(20):2586-94. PMID: 11722273.
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  67. Berke JD, Sgambato V, Zhu PP, Lavoie B, Vincent M, Krause M, Hyman SE. Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin. Neuron. 2001 Oct 25; 32(2):277-87. PMID: 11683997.
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  68. Hyman SE, Malenka RC. Addiction and the brain: the neurobiology of compulsion and its persistence. Nat Rev Neurosci. 2001 Oct; 2(10):695-703. PMID: 11584307.
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  69. Kosofsky BE, Hyman SE. No time for complacency: the fetal brain on drugs. J Comp Neurol. 2001 Jul 02; 435(3):259-62. PMID: 11406809.
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  70. Hyman SE. Mood disorders in children and adolescents: an NIMH perspective. Biol Psychiatry. 2001 Jun 15; 49(12):962-9. PMID: 11430838.
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  71. Hyman SE. Mental health in an aging population: the NIMH perspective. Am J Geriatr Psychiatry. 2001; 9(4):330-9. PMID: 11739060.
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  72. Hyman SE. The needs for database research and for privacy collide. Am J Psychiatry. 2000 Nov; 157(11):1723-4. PMID: 11058462.
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  73. Hyman S. Mental illness: genetically complex disorders of neural circuitry and neural communication. Neuron. 2000 Nov; 28(2):321-3. PMID: 11144341.
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  74. Kogai T, Curcio F, Hyman S, Cornford EM, Brent GA, Hershman JM. Induction of follicle formation in long-term cultured normal human thyroid cells treated with thyrotropin stimulates iodide uptake but not sodium/iodide symporter messenger RNA and protein expression. J Endocrinol. 2000 Oct; 167(1):125-35. PMID: 11018760.
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  75. Hyman SE. Genes, gene expression, and behavior. Neurobiol Dis. 2000 Oct; 7(5):528-32. PMID: 11042069.
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  76. Hyman SE. Goals for research on bipolar disorder: the view from NIMH. Biol Psychiatry. 2000 Sep 15; 48(6):436-41. PMID: 11018216.
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  77. Hyman SE. National Institute of Mental Health goals for behavioral science. Exp Clin Psychopharmacol. 2000 Aug; 8(3):271-2. PMID: 10975615.
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  78. Hyman SE, Shore D. An NIMH perspective on the use of placebos. National Institute of Mental Health. Biol Psychiatry. 2000 Apr 15; 47(8):689-91. PMID: 10773173.
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  79. Berke JD, Hyman SE. Addiction, dopamine, and the molecular mechanisms of memory. Neuron. 2000 Mar; 25(3):515-32. PMID: 10774721.
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  80. Hyman SE. The millennium of mind, brain, and behavior. Arch Gen Psychiatry. 2000 Jan; 57(1):88-9. PMID: 10632239.
    View in: PubMed
  81. Hyman SE. The NIMH perspective: next steps in schizophrenia research. Biol Psychiatry. 2000 Jan 01; 47(1):1-7. PMID: 10650443.
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  82. Hyman SE. The genetics of mental illness: implications for practice. Bull World Health Organ. 2000; 78(4):455-63. PMID: 10885164; PMCID: PMC2560734.
    View in: PubMed, PubMed Central
  83. Shore D, Hyman SE. An NIMH commentary on the NBAC report. Biol Psychiatry. 1999 Oct 15; 46(8):1013-6. PMID: 10536736.
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  84. Shore D, Hyman SE. NIMH symptom challenge and medication discontinuation workshop. Biol Psychiatry. 1999 Oct 15; 46(8):1009-10. PMID: 10536734.
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  85. Hyman SE. Selective gene expression increases behavioral sensitivity to cocaine. Nat Neurosci. 1999 Oct; 2(10):855-6. PMID: 10491599.
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  86. Norquist G, Hyman SE. Advances in understanding and treating mental illness: implications for policy. Health Aff (Millwood). 1999 Sep-Oct; 18(5):32-47. PMID: 10495590.
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  87. Mosher LR, Goodwin FK, Thompson J, Hyman SE, Emmet W. Are psychiatrists betraying their patients? Psychol Today. 1999 Sep-Oct; 32(5):40-42, 80, 82. PMID: 11660751.
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  88. Kobierski LA, Wong AE, Srivastava S, Borsook D, Hyman SE. Cyclic AMP-dependent activation of the proenkephalin gene requires phosphorylation of CREB at serine-133 and a Src-related kinase. J Neurochem. 1999 Jul; 73(1):129-38. PMID: 10386963.
    View in: PubMed
  89. Schwarzschild MA, Cole RL, Meyers MA, Hyman SE. Contrasting calcium dependencies of SAPK and ERK activations by glutamate in cultured striatal neurons. J Neurochem. 1999 Jun; 72(6):2248-55. PMID: 10349832.
    View in: PubMed
  90. Van Koughnet K, Smirnova O, Hyman SE, Borsook D. Proenkephalin transgene regulation in the paraventricular nucleus of the hypothalamus by lipopolysaccharide and interleukin-1beta. J Comp Neurol. 1999 Mar 08; 405(2):199-215. PMID: 10023810.
    View in: PubMed
  91. Hyman SE. Protecting patients, preserving progress: ethics in mental health illness research. Acad Med. 1999 Mar; 74(3):258-9. PMID: 10099647.
    View in: PubMed
  92. Hyman SE. Introduction to the complex genetics of mental disorders. Biol Psychiatry. 1999 Mar 01; 45(5):518-21. PMID: 10088041.
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  93. Morwood DT, Nichter LS, Hyman S, Bindiger A, Miller JH, McComb JG. Omental transfer to the brain: an experimental study in hydrocephalic rabbits. Ann Plast Surg. 1999 Feb; 42(2):174-9. PMID: 10029483.
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  94. Hyman SE. Brain neurocircuitry of anxiety and fear: implications for clinical research and practice. Biol Psychiatry. 1998 Dec 15; 44(12):1201-3. PMID: 9861461.
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  95. Hyman SE. NIMH during the tenure of Director Steven E. Hyman, M.D. (1996-present): the now and future of NIMH. Am J Psychiatry. 1998 Sep; 155(9 Suppl):36-40. PMID: 9736863.
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  96. Genova LM, Hyman SE. 5-HT3 receptor activation is required for induction of striatal c-Fos and phosphorylation of ATF-1 by amphetamine. Synapse. 1998 Sep; 30(1):71-8. PMID: 9704883.
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  97. Fienberg AA, Hiroi N, Mermelstein PG, Song W, Snyder GL, Nishi A, Cheramy A, O'Callaghan JP, Miller DB, Cole DG, Corbett R, Haile CN, Cooper DC, Onn SP, Grace AA, Ouimet CC, White FJ, Hyman SE, Surmeier DJ, Girault J, Nestler EJ, Greengard P. DARPP-32: regulator of the efficacy of dopaminergic neurotransmission. Science. 1998 Aug 07; 281(5378):838-42. PMID: 9694658.
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  98. Berke JD, Paletzki RF, Aronson GJ, Hyman SE, Gerfen CR. A complex program of striatal gene expression induced by dopaminergic stimulation. J Neurosci. 1998 Jul 15; 18(14):5301-10. PMID: 9651213.
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  99. Gollub RL, Breiter HC, Kantor H, Kennedy D, Gastfriend D, Mathew RT, Makris N, Guimaraes A, Riorden J, Campbell T, Foley M, Hyman SE, Rosen B, Weisskoff R. Cocaine decreases cortical cerebral blood flow but does not obscure regional activation in functional magnetic resonance imaging in human subjects. J Cereb Blood Flow Metab. 1998 Jul; 18(7):724-34. PMID: 9663502.
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  100. Hyman SE, Zuckerman B. Drug interactions in cocaine abuse: methodologic concerns in human and animal studies. Ann N Y Acad Sci. 1998 Jun 21; 846:69-75. PMID: 9668398.
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  101. Hyman SE. A new image for fear and emotion. Nature. 1998 Jun 04; 393(6684):417-8. PMID: 9623995.
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  102. Cornford EM, Hyman S, Cornford ME, Damian RT. Glut1 glucose transporter in the primate choroid plexus endothelium. J Neuropathol Exp Neurol. 1998 May; 57(5):404-14. PMID: 9596411.
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  103. Cornford EM, Hyman S, Cornford ME, Landaw EM, Delgado-Escueta AV. Interictal seizure resections show two configurations of endothelial Glut1 glucose transporter in the human blood-brain barrier. J Cereb Blood Flow Metab. 1998 Jan; 18(1):26-42. PMID: 9428303.
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  104. Hyman SE. The K-05 award controversy. Arch Gen Psychiatry. 1998 Jan; 55(1):21-2. PMID: 9435755.
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  105. Glick TH, Armstrong EG, Waterman MA, Hundert EM, Hyman SE. An integrated preclerkship curriculum in neuroscience, psychiatry, and neurology. Acad Psychiatry. 1997 Dec; 21(4):212-8. PMID: 24435648.
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  106. Breiter HC, Gollub RL, Weisskoff RM, Kennedy DN, Makris N, Berke JD, Goodman JM, Kantor HL, Gastfriend DR, Riorden JP, Mathew RT, Rosen BR, Hyman SE. Acute effects of cocaine on human brain activity and emotion. Neuron. 1997 Sep; 19(3):591-611. PMID: 9331351.
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  107. Schwarzschild MA, Cole RL, Hyman SE. Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons. J Neurosci. 1997 May 15; 17(10):3455-66. PMID: 9133371.
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  108. Glick TH, Armstrong EG, Hyman SE, Hundert EM, Furshpan EJ. Neurologic education for the future: a decade of curricular reform at Harvard Medical School. Eur J Neurol. 1997 Mar; 4(2):102-6. PMID: 24283899.
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  109. Genova L, Berke J, Hyman SE. Molecular adaptations to psychostimulants in striatal neurons: toward a pathophysiology of addiction. Neurobiol Dis. 1997; 4(3-4):239-46. PMID: 9361300.
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  110. Berhow MT, Hiroi N, Kobierski LA, Hyman SE, Nestler EJ. Influence of cocaine on the JAK-STAT pathway in the mesolimbic dopamine system. J Neurosci. 1996 Dec 15; 16(24):8019-26. PMID: 8987828.
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  111. Breiter HC, Etcoff NL, Whalen PJ, Kennedy WA, Rauch SL, Buckner RL, Strauss MM, Hyman SE, Rosen BR. Response and habituation of the human amygdala during visual processing of facial expression. Neuron. 1996 Nov; 17(5):875-87. PMID: 8938120.
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  112. Hyman SE. Shaking out the cause of addiction. Science. 1996 Aug 02; 273(5275):611-2. PMID: 8701316.
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  113. Konradi C, Leveque JC, Hyman SE. Amphetamine and dopamine-induced immediate early gene expression in striatal neurons depends on postsynaptic NMDA receptors and calcium. J Neurosci. 1996 Jul 01; 16(13):4231-9. PMID: 8753884; PMCID: PMC4203342.
    View in: PubMed, PubMed Central
  114. Hyman SE. Addiction to cocaine and amphetamine. Neuron. 1996 May; 16(5):901-4. PMID: 8630246.
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  115. Hyman SE, Nestler EJ. Initiation and adaptation: a paradigm for understanding psychotropic drug action. Am J Psychiatry. 1996 Feb; 153(2):151-62. PMID: 8561194.
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  116. Hyman SE, Borsook D. Mechanisms regulating proenkephalin gene expression: contributions of transgenic models. NIDA Res Monogr. 1996; 161:59-71. PMID: 8784844.
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  117. Hyman SE. A man with alcoholism and HIV infection. JAMA. 1995 Sep 13; 274(10):837-43. PMID: 7650809.
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  118. Hyman SE. Current treatment for alcohol withdrawal. J Gen Intern Med. 1995 Sep; 10(9):523-4. PMID: 8523158.
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  119. Borsook D, Hyman SE. Proenkephalin gene regulation in the neuroendocrine hypothalamus: a model of gene regulation in the CNS. Am J Physiol. 1995 Sep; 269(3 Pt 1):E393-408. PMID: 7573416.
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  120. Konradi C, Cole RL, Green D, Senatus P, Leveque JC, Pollack AE, Grossbard SJ, Hyman SE. Analysis of the proenkephalin second messenger-inducible enhancer in rat striatal cultures. J Neurochem. 1995 Sep; 65(3):1007-15. PMID: 7643080.
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  121. Gollub RL, Hyman SE. G proteins and second messengers in psychiatry. Harv Rev Psychiatry. 1995 May-Jun; 3(1):41-4. PMID: 9410573.
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  122. Naidu S, Hyman S, Harris EL, Narayanan V, Johns D, Castora F. Rett syndrome studies of natural history and search for a genetic marker. Neuropediatrics. 1995 Apr; 26(2):63-6. PMID: 7566454.
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  123. Cole RL, Konradi C, Douglass J, Hyman SE. Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron. 1995 Apr; 14(4):813-23. PMID: 7718243; PMCID: PMC4207064.
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  124. Hyman SE, Cole RL, Konradi C, Kosofsky BE. Dopamine regulation of transcription factor-target interactions in rat striatum. Chem Senses. 1995 Apr; 20(2):257-60. PMID: 7583020.
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  125. Kosofsky BE, Genova LM, Hyman SE. Postnatal age defines specificity of immediate early gene induction by cocaine in developing rat brain. J Comp Neurol. 1995 Jan 02; 351(1):27-40. PMID: 7896938.
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  126. Kosofsky BE, Genova LM, Hyman SE. Substance P phenotype defines specificity of c-fos induction by cocaine in developing rat striatum. J Comp Neurol. 1995 Jan 02; 351(1):41-50. PMID: 7534774.
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  127. Symes A, Lewis S, Corpus L, Rajan P, Hyman SE, Fink JS. STAT proteins participate in the regulation of the vasoactive intestinal peptide gene by the ciliary neurotrophic factor family of cytokines. Mol Endocrinol. 1994 Dec; 8(12):1750-63. PMID: 7708062.
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  128. Borsook D, Falkowski O, Rosen H, Comb M, Hyman SE. Opioids modulate stress-induced proenkephalin gene expression in the hypothalamus of transgenic mice: a model of endogenous opioid gene regulation by exogenous opioids. J Neurosci. 1994 Dec; 14(12):7261-71. PMID: 7996174.
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  129. Cornford EM, Hyman S, Landaw EM. Developmental modulation of blood-brain-barrier glucose transport in the rabbit. Brain Res. 1994 Nov 07; 663(1):7-18. PMID: 7850472.
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  130. Hyman SE, Gollub RL. More serotonin: not as simple as it seems. Harv Rev Psychiatry. 1994 Nov-Dec; 2(4):222-4. PMID: 9384905.
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  131. Schwarzschild MA, Dauer WT, Lewis SE, Hamill LK, Fink JS, Hyman SE. Leukemia inhibitory factor and ciliary neurotrophic factor increase activated Ras in a neuroblastoma cell line and in sympathetic neuron cultures. J Neurochem. 1994 Oct; 63(4):1246-54. PMID: 7523587.
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  132. Cole DG, Kobierski LA, Konradi C, Hyman SE. 6-Hydroxydopamine lesions of rat substantia nigra up-regulate dopamine-induced phosphorylation of the cAMP-response element-binding protein in striatal neurons. Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20):9631-5. PMID: 7937819; PMCID: PMC44867.
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  133. Konradi C, Cole RL, Heckers S, Hyman SE. Amphetamine regulates gene expression in rat striatum via transcription factor CREB. J Neurosci. 1994 Sep; 14(9):5623-34. PMID: 8083758.
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  134. Lewis SE, Rao MS, Symes AJ, Dauer WT, Fink JS, Landis SC, Hyman SE. Coordinate regulation of choline acetyltransferase, tyrosine hydroxylase, and neuropeptide mRNAs by ciliary neurotrophic factor and leukemia inhibitory factor in cultured sympathetic neurons. J Neurochem. 1994 Aug; 63(2):429-38. PMID: 7518494.
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  135. Hyman SE. Why does the brain prefer opium to broccoli? Harv Rev Psychiatry. 1994 May-Jun; 2(1):43-6. PMID: 9384879.
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  136. Borsook D, Konradi C, Falkowski O, Comb M, Hyman SE. Molecular mechanisms of stress-induced proenkephalin gene regulation: CREB interacts with the proenkephalin gene in the mouse hypothalamus and is phosphorylated in response to hyperosmolar stress. Mol Endocrinol. 1994 Feb; 8(2):240-8. PMID: 8170480; PMCID: PMC4205567.
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  137. Hyman SE. Another one bites the dust: an infectious origin for peptic ulcers. Harv Rev Psychiatry. 1994 Jan-Feb; 1(5):294-5. PMID: 9384861.
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  138. Hyman SE, Konradi C, Kobierski L, Cole R, Senatus P, Green D. Pharmacologic regulation of striatal proenkephalin gene expression via transcription factor CREB. Prog Clin Biol Res. 1994; 390:155-71. PMID: 7724644.
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  139. Cornford EM, Hyman S, Swartz BE. The human brain GLUT1 glucose transporter: ultrastructural localization to the blood-brain barrier endothelia. J Cereb Blood Flow Metab. 1994 Jan; 14(1):106-12. PMID: 8263045.
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  140. Borsook D, Falkowski O, Burstein R, Strassman A, Konradi C, Dauber A, Comb M, Hyman SE. Stress-induced regulation of a human proenkephalin-beta-galactosidase fusion gene in the hypothalamus of transgenic mice. Mol Endocrinol. 1994 Jan; 8(1):116-25. PMID: 8152426.
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  141. Cornford EM, Hyman S, Pardridge WM. An electron microscopic immunogold analysis of developmental up-regulation of the blood-brain barrier GLUT1 glucose transporter. J Cereb Blood Flow Metab. 1993 Sep; 13(5):841-54. PMID: 8360290.
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  142. Hyman SE. Molecular and cell biology of addiction. Curr Opin Neurol Neurosurg. 1993 Aug; 6(4):609-13. PMID: 8400475.
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  143. Konradi C, Kobierski LA, Nguyen TV, Heckers S, Hyman SE. The cAMP-response-element-binding protein interacts, but Fos protein does not interact, with the proenkephalin enhancer in rat striatum. Proc Natl Acad Sci U S A. 1993 Aug 01; 90(15):7005-9. PMID: 8346209; PMCID: PMC47064.
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  144. Hyman SE. New insights into how antipsychotic drugs might work. Harv Rev Psychiatry. 1993 May-Jun; 1(1):68-9. PMID: 9384831.
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  145. Tang G, Hyman S, Schneider JH, Giannotta SL. Application of photodynamic therapy to the treatment of atherosclerotic plaques. Neurosurgery. 1993 Mar; 32(3):438-43; discussion 443. PMID: 8455769.
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  146. Symes AJ, Rao MS, Lewis SE, Landis SC, Hyman SE, Fink JS. Ciliary neurotrophic factor coordinately activates transcription of neuropeptide genes in a neuroblastoma cell line. Proc Natl Acad Sci U S A. 1993 Jan 15; 90(2):572-6. PMID: 8093644; PMCID: PMC45705.
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  147. Hyman SE, Kosofsky BE, Nguyen TV, Cohen BM, Comb MJ. Everything activates c-fos--how can it matter? NIDA Res Monogr. 1993; 125:25-38. PMID: 8341366.
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  148. Kosofsky BE, Hyman SE. The ontogeny of immediate early gene response to cocaine: a molecular analysis of the effects of cocaine on developing rat brain. NIDA Res Monogr. 1993; 125:161-71. PMID: 8341363.
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  149. Borsook D, Rosen H, Collard M, Dressler H, Herrup K, Comb MJ, Hyman SE. Expression and regulation of a proenkephalin beta-galactosidase fusion gene in the reproductive system of transgenic mice. Mol Endocrinol. 1992 Sep; 6(9):1502-12. PMID: 1435791.
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  150. Hope B, Kosofsky B, Hyman SE, Nestler EJ. Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):5764-8. PMID: 1631058; PMCID: PMC402098.
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  151. Nguyen TV, Kosofsky BE, Birnbaum R, Cohen BM, Hyman SE. Differential expression of c-fos and zif268 in rat striatum after haloperidol, clozapine, and amphetamine. Proc Natl Acad Sci U S A. 1992 May 15; 89(10):4270-4. PMID: 1374894; PMCID: PMC49063.
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  152. Comb MJ, Kobierski L, Chu HM, Tan Y, Borsook D, Herrup K, Hyman SE. Regulation of opioid gene expression: a model to understand neural plasticity. NIDA Res Monogr. 1992; 126:98-112. PMID: 1491720.
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  153. Zlokovic BV, Hyman S, McComb JG, Tang G, Rezai AR, Weiss MH. Vasopressin uptake by hypothalamopituitary axis and pineal gland in guinea pigs. Am J Physiol. 1991 Apr; 260(4 Pt 1):E633-40. PMID: 1902062.
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  154. Zlokovic BV, Segal MB, McComb JG, Hyman S, Weiss MH, Davson H. Kinetics of circulating vasopressin uptake by choroid plexus. Am J Physiol. 1991 Feb; 260(2 Pt 2):F216-24. PMID: 1899978.
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  155. Comb M, Hyman SE, Kobierski L, Chu HM, Van Nguyen T. Mechanisms underlying synaptic regulation of proenkephalin transcription. NIDA Res Monogr. 1991; 111:149-70. PMID: 1663581.
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  156. Jenike MA, Hyman S, Baer L, Holland A, Minichiello WE, Buttolph L, Summergrad P, Seymour R, Ricciardi J. A controlled trial of fluvoxamine in obsessive-compulsive disorder: implications for a serotonergic theory. Am J Psychiatry. 1990 Sep; 147(9):1209-15. PMID: 2143637.
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  157. Van Nguyen T, Kobierski L, Comb M, Hyman SE. The effect of depolarization on expression of the human proenkephalin gene is synergistic with cAMP and dependent upon a cAMP-inducible enhancer. J Neurosci. 1990 Aug; 10(8):2825-33. PMID: 2167356.
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  158. Ross ME, Evinger MJ, Hyman SE, Carroll JM, Mucke L, Comb M, Reis DJ, Joh TH, Goodman HM. Identification of a functional glucocorticoid response element in the phenylethanolamine N-methyltransferase promoter using fusion genes introduced into chromaffin cells in primary culture. J Neurosci. 1990 Feb; 10(2):520-30. PMID: 2303857.
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  159. Cohen BM, Nguyen TV, Hyman SE. Cocaine-induced changes in gene expression in rat brain. NIDA Res Monogr. 1990; 105:175-81. PMID: 1831539.
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  160. Erlich SS, McComb JG, Hyman S, Weiss MH. Ultrastructure of the orbital pathway for cerebrospinal fluid drainage in rabbits. J Neurosurg. 1989 Jun; 70(6):926-31. PMID: 2715821.
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  161. Breeze RE, McComb JG, Hyman S, Gilles FH. CSF production in acute ventriculitis. J Neurosurg. 1989 Apr; 70(4):619-22. PMID: 2647919.
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  162. Hyman SE, Comb M, Pearlberg J, Goodman HM. An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene. Mol Cell Biol. 1989 Jan; 9(1):321-4. PMID: 2538722; PMCID: PMC362175.
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  163. Comb M, Mermod N, Hyman SE, Pearlberg J, Ross ME, Goodman HM. Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription. EMBO J. 1988 Dec 01; 7(12):3793-805. PMID: 2850173; PMCID: PMC454956.
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  164. Hyman SE, Comb M, Lin YS, Pearlberg J, Green MR, Goodman HM. A common trans-acting factor is involved in transcriptional regulation of neurotransmitter genes by cyclic AMP. Mol Cell Biol. 1988 Oct; 8(10):4225-33. PMID: 2903436; PMCID: PMC365494.
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  165. Neave V, Giannotta S, Hyman S, Schneider J. Hematoporphyrin uptake in atherosclerotic plaques: therapeutic potentials. Neurosurgery. 1988 Sep; 23(3):307-12. PMID: 2976125.
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  166. Hyman SE. Recent developments in neurobiology: Part II. Neurotransmitter receptors and psychopharmacology. Psychosomatics. 1988; 29(3):254-63. PMID: 2900534.
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  167. Hyman SE. The role of molecular biology in psychiatry. Psychosomatics. 1988; 29(3):328-32. PMID: 2900535.
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  168. Hyman SE. Recent developments in neurobiology: Part III. Effectors of transmitter action. Psychosomatics. 1988; 29(4):373-8. PMID: 2906447.
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  169. Hyman SE. Recent developments in neurobiology: Part I. Synaptic transmission. Psychosomatics. 1988; 29(2):157-65. PMID: 2453072.
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  170. Schalling M, Dagerlind A, Brene S, Petterson R, Kvist S, Brownstein M, Hyman SE, Mucke L, Goodman HM, Joh TH, et al. Localization of mRNA for phenylethanolamine N-methyltransferase (PNMT) using in situ hybridization. Acta Physiol Scand. 1987 Dec; 131(4):631-2. PMID: 3442246.
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  171. Hyman S, McComb JG, Megerdichian L, Weiss MH. Blood-cerebrospinal fluid barrier alteration following intraventricularly administered cholera toxin. Brain Res. 1987 Sep 01; 419(1-2):104-11. PMID: 2445419.
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  172. Pollack MH, Rosenbaum JF, Hyman SE. Calcium channel blockers in psychiatry. Psychosomatics. 1987 Jul; 28(7):356-60, 369. PMID: 3326023.
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  173. Wood M, Hyman S, Wood AJ. A clinical study of sensitivity to sodium nitroprusside during controlled hypotensive anesthesia in young and elderly patients. Anesth Analg. 1987 Feb; 66(2):132-6. PMID: 3028217.
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  174. Little FM, Gomer CJ, Hyman S, Apuzzo ML. Observations in studies of quantitative kinetics of tritium labelled hematoporphyrin derivatives (HpDI and HpDII) in the normal and neoplastic rat brain model. J Neurooncol. 1984; 2(4):361-70. PMID: 6241630.
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  175. Oldendorf WH, Hyman S, Braun L, Oldendorf SZ. Blood-brain barrier: penetration of morphine, codeine, heroin, and methadone after carotid injection. Science. 1972 Dec 01; 178(4064):984-6. PMID: 5084666.
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  176. HYMAN S, VILLA F, STEIGMANN F. Mimetic aspects of ascites. JAMA. 1963 Feb 23; 183:651-5. PMID: 13956014.
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  177. CAPOS NJ, HYMAN S. Cancer in the residual stomach after gastric resection for duodenal ulcer. JAMA. 1961 Aug 12; 177:448-9. PMID: 13690597.
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