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Gary B Kaplan, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. I21RX003722 (KAPLAN, GARY B.) Jul 1, 2021 - Jun 30, 2023
    Treatment of Sleep Disturbances in TBI with Orexin Receptor Antagonist
    Role: Principal Investigator
  2. I01RX001144 (KAPLAN, GARY B.) Aug 1, 2015 - Jan 31, 2021
    Behavioral and Neural Plasticity in TBI and PTSD
    Role: Principal Investigator
  3. I01BX000814 (KAPLAN, GARY B.) Jan 1, 2011 - Dec 31, 2014
    Therapeutic Approaches for Extinction of Conditioned Drug Reward
    Role: Principal Investigator
  4. I01RX000361 (KAPLAN, GARY B.) Oct 1, 2010 - Sep 30, 2012
    Neurotrophic factor mechanisms in treatments in TBI and PTSD
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kaplan GB, Lakis GA, Zhoba H. Sleep-wake and arousal dysfunctions in post-traumatic stress disorder: Role of orexin systems. Brain Res Bull. 2022 08; 186:106-122. PMID: 35618150.
    Citations:    Fields:    Translation:Animals
  2. Brown RE, Spratt TJ, Kaplan GB. Translational approaches to influence sleep and arousal. Brain Res Bull. 2022 07; 185:140-161. PMID: 35550156.
    Citations:    Fields:    Translation:Humans
  3. Liverant GI, Gallagher MW, Arditte Hall KA, Rosebrock LE, Black SK, Kind S, Fava M, Kaplan GB, Kamholz BW, Pineles SL, Sloan DM. Suppression and acceptance in unipolar depression: Short-term and long-term effects on emotional responding. Br J Clin Psychol. 2022 Mar; 61(1):1-17. PMID: 34268773.
    Citations:    Fields:    Translation:Humans
  4. Thompson BL, Oscar-Berman M, Kaplan GB. Opioid-induced structural and functional plasticity of medium-spiny neurons in the nucleus accumbens. Neurosci Biobehav Rev. 2021 01; 120:417-430. PMID: 33152423.
    Citations: 9     Fields:    Translation:Cells
  5. Kaplan GB, Leite-Morris KA, Wang L, Rumbika KK, Heinrichs SC, Zeng X, Wu L, Arena DT, Teng YD. Pathophysiological Bases of Comorbidity: Traumatic Brain Injury and Post-Traumatic Stress Disorder. J Neurotrauma. 2018 01 15; 35(2):210-225. PMID: 29017388.
    Citations: 23     Fields:    Translation:Humans
  6. Kobrin KL, Arena DT, Heinrichs SC, Nguyen OH, Kaplan GB. Dopamine D1 receptor agonist treatment attenuates extinction of morphine conditioned place preference while increasing dendritic complexity in the nucleus accumbens core. Behav Brain Res. 2017 03 30; 322(Pt A):18-28. PMID: 28089852.
    Citations: 2     Fields:    Translation:AnimalsCells
  7. Kobrin KL, Moody O, Arena DT, Moore CF, Heinrichs SC, Kaplan GB. Acquisition of morphine conditioned place preference increases the dendritic complexity of nucleus accumbens core neurons. Addict Biol. 2016 11; 21(6):1086-1096. PMID: 26096355.
    Citations: 10     Fields:    Translation:AnimalsCells
  8. Liverant GI, Sloan DM, Pizzagalli DA, Harte CB, Kamholz BW, Rosebrock LE, Cohen AL, Fava M, Kaplan GB. Associations among smoking, anhedonia, and reward learning in depression. Behav Ther. 2014 Sep; 45(5):651-63. PMID: 25022776.
    Citations: 10     Fields:    Translation:Humans
  9. Leite-Morris KA, Kobrin KL, Guy MD, Young AJ, Heinrichs SC, Kaplan GB. Extinction of opiate reward reduces dendritic arborization and c-Fos expression in the nucleus accumbens core. Behav Brain Res. 2014 Apr 15; 263:51-9. PMID: 24406724.
    Citations: 9     Fields:    Translation:AnimalsCells
  10. Harte CB, Liverant GI, Sloan DM, Kamholz BW, Rosebrock LE, Fava M, Kaplan GB. Association between smoking and heart rate variability among individuals with depression. Ann Behav Med. 2013 Aug; 46(1):73-80. PMID: 23436273.
    Citations: 5     Fields:    Translation:Humans
  11. Heinrichs SC, Leite-Morris KA, Rasmusson AM, Kaplan GB. Repeated valproate treatment facilitates fear extinction under specific stimulus conditions. Neurosci Lett. 2013 Sep 27; 552:108-13. PMID: 23916657.
    Citations: 8     Fields:    Translation:Animals
  12. Heinrichs SC, Leite-Morris KA, Guy MD, Goldberg LR, Young AJ, Kaplan GB. Dendritic structural plasticity in the basolateral amygdala after fear conditioning and its extinction in mice. Behav Brain Res. 2013 Jul 01; 248:80-4. PMID: 23570859.
    Citations: 18     Fields:    Translation:AnimalsCells
  13. Nic Dhonnchadha BÁ, Lin A, Leite-Morris KA, Kaplan GB, Man HY, Kantak KM. Alterations in expression and phosphorylation of GluA1 receptors following cocaine-cue extinction learning. Behav Brain Res. 2013 Feb 01; 238:119-23. PMID: 23085477.
    Citations: 13     Fields:    Translation:AnimalsCells
  14. Nic Dhonnchadha BÁ, Lovascio BF, Shrestha N, Lin A, Leite-Morris KA, Man HY, Kaplan GB, Kantak KM. Changes in expression of c-Fos protein following cocaine-cue extinction learning. Behav Brain Res. 2012 Sep 01; 234(1):100-6. PMID: 22721675.
    Citations: 13     Fields:    Translation:Animals
  15. Tidey JW, Rohsenow DJ, Kaplan GB, Swift RM, Ahnallen CG. Separate and combined effects of very low nicotine cigarettes and nicotine replacement in smokers with schizophrenia and controls. Nicotine Tob Res. 2013 Jan; 15(1):121-9. PMID: 22517190; PMCID: PMC3524060.
    Citations: 39     Fields:    Translation:Humans
  16. Ahnallen CG, Liverant GI, Gregor KL, Kamholz BW, Levitt JJ, Gulliver SB, Pizzagalli DA, Koneru VK, Kaplan GB. The relationship between reward-based learning and nicotine dependence in smokers with schizophrenia. Psychiatry Res. 2012 Mar 30; 196(1):9-14. PMID: 22342123.
    Citations: 21     Fields:    Translation:Humans
  17. Kaplan GB, Leite-Morris KA, Fan W, Young AJ, Guy MD. Opiate sensitization induces FosB/?FosB expression in prefrontal cortical, striatal and amygdala brain regions. PLoS One. 2011; 6(8):e23574. PMID: 21886798.
    Citations: 14     Fields:    Translation:Animals
  18. Tidey JW, Rohsenow DJ, Kaplan GB, Swift RM, Reid N. Effects of contingency management and bupropion on cigarette smoking in smokers with schizophrenia. Psychopharmacology (Berl). 2011 Sep; 217(2):279-87. PMID: 21475970.
    Citations: 34     Fields:    Translation:Humans
  19. Kaplan GB, Moore KA. The use of cognitive enhancers in animal models of fear extinction. Pharmacol Biochem Behav. 2011 Aug; 99(2):217-28. PMID: 21256147.
    Citations: 46     Fields:    Translation:HumansAnimals
  20. Kaplan GB, Vasterling JJ, Vedak PC. Brain-derived neurotrophic factor in traumatic brain injury, post-traumatic stress disorder, and their comorbid conditions: role in pathogenesis and treatment. Behav Pharmacol. 2010 Sep; 21(5-6):427-37. PMID: 20679891.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  21. Kaplan GB, Heinrichs SC, Carey RJ. Treatment of addiction and anxiety using extinction approaches: neural mechanisms and their treatment implications. Pharmacol Biochem Behav. 2011 Jan; 97(3):619-25. PMID: 20723558.
    Citations: 33     Fields:    Translation:HumansAnimals
  22. Sirota AD, Rohsenow DJ, Mackinnon SV, Martin RA, Eaton CA, Kaplan GB, Monti PM, Tidey JW, Swift RM. Intolerance for Smoking Abstinence Questionnaire: psychometric properties and relationship to tobacco dependence and abstinence. Addict Behav. 2010 Jul; 35(7):686-93. PMID: 20381260.
    Citations: 21     Fields:    Translation:Humans
  23. Heinrichs SC, Leite-Morris KA, Carey RJ, Kaplan GB. Baclofen enhances extinction of opiate conditioned place preference. Behav Brain Res. 2010 Mar 05; 207(2):353-9. PMID: 19840820.
    Citations: 22     Fields:    Translation:Animals
  24. Kaplan GB, Leite-Morris KA, Klufas MA, Fan W. Intra-VTA adenosine A1 receptor activation blocks morphine stimulation of motor behavior and cortical and limbic Fos immunoreactivity. Eur J Pharmacol. 2009 Jan 14; 602(2-3):268-76. PMID: 19027733.
    Citations: 1     Fields:    Translation:AnimalsCells
  25. Tidey JW, Rohsenow DJ, Kaplan GB, Swift RM, Adolfo AB. Effects of smoking abstinence, smoking cues and nicotine replacement in smokers with schizophrenia and controls. Nicotine Tob Res. 2008 Jun; 10(6):1047-56. PMID: 18584468.
    Citations: 25     Fields:    Translation:Humans
  26. Rohsenow DJ, Monti PM, Hutchison KE, Swift RM, MacKinnon SV, Sirota AD, Kaplan GB. High-dose transdermal nicotine and naltrexone: effects on nicotine withdrawal, urges, smoking, and effects of smoking. Exp Clin Psychopharmacol. 2007 Feb; 15(1):81-92. PMID: 17295587.
    Citations: 26     Fields:    Translation:Humans
  27. Kaplan GB, Phillips KA, Vaccaro A, Eisen JL, Posternak MA, MacAskill HS. Assessment of insight into delusional beliefs in schizophrenia using the Brown Assessment of Beliefs Scale. Schizophr Res. 2006 Feb 28; 82(2-3):279-81. PMID: 16406495; PMCID: PMC1626389.
    Citations: 5     Fields:    Translation:Humans
  28. Epstein-Lubow G, Hochstadt J, Lieberman P, Kaplan GB. Speech production in schizophrenia: preliminary data regarding voice onset time. Schizophr Res. 2006 Feb 28; 82(2-3):267-9. PMID: 16371248.
    Citations:    Fields:    Translation:Humans
  29. Tidey JW, Rohsenow DJ, Kaplan GB, Swift RM. Cigarette smoking topography in smokers with schizophrenia and matched non-psychiatric controls. Drug Alcohol Depend. 2005 Nov 01; 80(2):259-65. PMID: 15869844.
    Citations: 61     Fields:    Translation:Humans
  30. Tidey JW, Rohsenow DJ, Kaplan GB, Swift RM. Subjective and physiological responses to smoking cues in smokers with schizophrenia. Nicotine Tob Res. 2005 Jun; 7(3):421-9. PMID: 16085510.
    Citations: 15     Fields:    Translation:Humans
  31. Kaplan GB, McRoberts RL, Smokler HJ. Baclofen as adjunctive treatment for a patient with cocaine dependence and schizoaffective disorder. J Clin Psychopharmacol. 2004 Oct; 24(5):574-5. PMID: 15349029.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  32. Turalba AV, Leite-Morris KA, Kaplan GB. Antipsychotics regulate cyclic AMP-dependent protein kinase and phosphorylated cyclic AMP response element-binding protein in striatal and cortical brain regions in mice. Neurosci Lett. 2004 Feb 26; 357(1):53-7. PMID: 15036612.
    Citations: 14     Fields:    Translation:AnimalsCells
  33. Leite-Morris KA, Fukudome EY, Shoeb MH, Kaplan GB. GABA(B) receptor activation in the ventral tegmental area inhibits the acquisition and expression of opiate-induced motor sensitization. J Pharmacol Exp Ther. 2004 Feb; 308(2):667-78. PMID: 14610238.
    Citations: 21     Fields:    Translation:Animals
  34. Kaplan GB, Leite-Morris KA, Joshi M, Shoeb MH, Carey RJ. Baclofen inhibits opiate-induced conditioned place preference and associated induction of Fos in cortical and limbic regions. Brain Res. 2003 Oct 10; 987(1):122-5. PMID: 14499954.
    Citations: 9     Fields:    Translation:Animals
  35. Leite-Morris KA, Fukudome EY, Kaplan GB. Opiate-induced motor stimulation is regulated by gamma-aminobutyric acid type B receptors found in the ventral tegmental area in mice. Neurosci Lett. 2002 Jan 14; 317(3):119-22. PMID: 11755254.
    Citations: 8     Fields:    Translation:AnimalsCells
  36. Rohsenow DJ, Monti PM, Hutchison KE, Swift RM, Colby SM, Kaplan GB. Naltrexone's effects on reactivity to alcohol cues among alcoholic men. J Abnorm Psychol. 2000 Nov; 109(4):738-42. PMID: 11195999.
    Citations: 41     Fields:    Translation:HumansCTClinical Trials
  37. Kaplan GB, Greenblatt DJ, Ehrenberg BL, Goddard JE, Harmatz JS, Shader RI. Differences in pharmacodynamics but not pharmacokinetics between subjects with panic disorder and healthy subjects after treatment with a single dose of alprazolam. J Clin Psychopharmacol. 2000 Jun; 20(3):338-46. PMID: 10831021.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  38. Kaplan GB, Leite-Morris KA, Keith DJ. Differential effects of treatment with typical and atypical antipsychotic drugs on adenylyl cyclase and G proteins. Neurosci Lett. 1999 Oct 08; 273(3):147-50. PMID: 10515180.
    Citations: 4     Fields:    Translation:Animals
  39. Kaplan GB, Bharmal NH, Leite-Morris KA, Adams WR. Role of adenosine A1 and A2A receptors in the alcohol withdrawal syndrome. Alcohol. 1999 Oct; 19(2):157-62. PMID: 10548160.
    Citations: 20     Fields:    Translation:Animals
  40. Weisberg SP, Kaplan GB. Adenosine receptor antagonists inhibit the development of morphine sensitization in the C57BL/6 mouse. Neurosci Lett. 1999 Apr 02; 264(1-3):89-92. PMID: 10320021.
    Citations: 6     Fields:    Translation:Animals
  41. Kaplan GB, Coyle TS. Adenosine kinase inhibitors attenuate opiate withdrawal via adenosine receptor activation. Eur J Pharmacol. 1998 Nov 27; 362(1):1-8. PMID: 9865523.
    Citations: 6     Fields:    Translation:Animals
  42. Leite-Morris KA, Kaplan GB, Smith JG, Sears MT. Regulation of G proteins and adenylyl cyclase in brain regions of caffeine-tolerant and -dependent mice. Brain Res. 1998 Aug 31; 804(1):52-62. PMID: 9729274.
    Citations: 1     Fields:    Translation:Animals
  43. Kaplan GB, Sethi RK, McClelland EG, Leite-Morris KA. Regulation of G protein-mediated adenylyl cyclase in striatum and cortex of opiate-dependent and opiate withdrawing mice. Brain Res. 1998 Mar 30; 788(1-2):104-10. PMID: 9554971.
    Citations: 5     Fields:    Translation:Animals
  44. Kaplan GB, Greenblatt DJ, Ehrenberg BL, Goddard JE, Harmatz JS, Shader RI. Single-dose pharmacokinetics and pharmacodynamics of alprazolam in elderly and young subjects. J Clin Pharmacol. 1998 Jan; 38(1):14-21. PMID: 9597554.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  45. Kaplan GB, Greenblatt DJ, Ehrenberg BL, Goddard JE, Cotreau MM, Harmatz JS, Shader RI. Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans. J Clin Pharmacol. 1997 Aug; 37(8):693-703. PMID: 9378841.
    Citations: 63     Fields:    Translation:HumansCTClinical Trials
  46. Kaplan GB, Leite-Morris KA. Up-regulation of adenosine transporter-binding sites in striatum and hypothalamus of opiate tolerant mice. Brain Res. 1997 Jul 25; 763(2):215-20. PMID: 9296562.
    Citations: 6     Fields:    Translation:AnimalsCells
  47. Kaplan GB, Sears MT. Adenosine receptor agonists attenuate and adenosine receptor antagonists exacerbate opiate withdrawal signs. Psychopharmacology (Berl). 1996 Jan; 123(1):64-70. PMID: 8741956.
    Citations: 12     Fields:    Translation:Animals
  48. Kaplan GB, Leite-Morris KA, Sears MT. Alterations of adenosine A1 receptors in morphine dependence. Brain Res. 1994 Sep 19; 657(1-2):347-50. PMID: 7820640.
    Citations: 11     Fields:    Translation:AnimalsCells
  49. Kaplan GB, Greenblatt DJ, Kent MA, Cotreau-Bibbo MM. Caffeine treatment and withdrawal in mice: relationships between dosage, concentrations, locomotor activity and A1 adenosine receptor binding. J Pharmacol Exp Ther. 1993 Sep; 266(3):1563-72. PMID: 8371158.
    Citations: 18     Fields:    Translation:Animals
  50. Kaplan GB, Cotreau MM, Greenblatt DJ. Effects of benzodiazepine administration on A1 adenosine receptor binding in-vivo and ex-vivo. J Pharm Pharmacol. 1992 Aug; 44(8):700-3. PMID: 1359103.
    Citations: 5     Fields:    Translation:Animals
  51. Kaplan GB. Neurobiological aspects of panic disorder. R I Med. 1992 May; 75(5):247-51. PMID: 1351409.
    Citations: 1     Fields:    Translation:Humans
  52. Kaplan GB, Greenblatt DJ, Kent MA, Cotreau MM, Arcelin G, Shader RI. Caffeine-induced behavioral stimulation is dose-dependent and associated with A1 adenosine receptor occupancy. Neuropsychopharmacology. 1992 May; 6(3):145-53. PMID: 1599605.
    Citations: 15     Fields:    Translation:Animals
  53. Kaplan GB, Tai NT, Greenblatt DJ, Shader RI. Caffeine-induced behavioural stimulation is dose- and concentration-dependent. Br J Pharmacol. 1990 Jul; 100(3):435-40. PMID: 2390669; PMCID: PMC1917803.
    Citations: 9     Fields:    Translation:Animals
  54. Kaplan GB, Tai NT, Greenblatt DJ, Shader RI. Separate and combined effects of caffeine and alprazolam on motor activity and benzodiazepine receptor binding in vivo. Psychopharmacology (Berl). 1990; 101(4):539-44. PMID: 2167493.
    Citations: 1     Fields:    Translation:Animals
  55. Lopez F, Miller LG, Greenblatt DJ, Kaplan GB, Shader RI. Interaction of caffeine with the GABAA receptor complex: alterations in receptor function but not ligand binding. Eur J Pharmacol. 1989 Dec 05; 172(6):453-9. PMID: 2482188.
    Citations: 14     Fields:    Translation:AnimalsCells
  56. Kaplan GB, Greenblatt DJ, Leduc BW, Thompson ML, Shader RI. Relationship of plasma and brain concentrations of caffeine and metabolites to benzodiazepine receptor binding and locomotor activity. J Pharmacol Exp Ther. 1989 Mar; 248(3):1078-83. PMID: 2539455.
    Citations: 17     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.