Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

profileUwe Rudolph, Dr.Med.

TitleProfessor of Psychiatry
InstitutionMcLean Hospital
DepartmentPsychiatry
AddressMcLean Hospital
Lab of Genetic Neuropharmacology
115 Mill St
Belmont MA 02478
Phone6178552088
Fax6178552012
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21MH104505     (RUDOLPH, UWE)Jul 1, 2014 - Jun 30, 2016
NIH/NIMH
Neurobiological relevance of 9p24.1 CNVs for bipolar disorder and schizophrenia
Role: Principal Investigator

R03DA033491     (RUDOLPH, UWE)Sep 15, 2012 - Aug 31, 2014
NIH/NIDA
The Role of GABA A Receptor Subtypes in Benzodiazepine Abuse Liability
Role: Principal Investigator

R01MH095905     (RUDOLPH, UWE)Jun 7, 2012 - Feb 28, 2017
NIH/NIMH
A GABA Pathway to Faster Acting Antidepressants
Role: Principal Investigator

R03MH094834     (RUDOLPH, UWE)Jan 6, 2012 - Dec 31, 2014
NIH/NIMH
Emotional regulation: Modeling GABA A receptor subtype specific agents in mice
Role: Principal Investigator

R21MH087829     (RUDOLPH, UWE)Apr 1, 2010 - Jun 30, 2013
NIH/NIMH
Generation of etiological models for schizophrenia by chromosome engineering
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Li S, Uno Y, Rudolph U, Cobb J, Liu J, Anderson T, Levy D, Balu DT, Coyle JT. Astrocytes in primary cultures express serine racemase, synthesize d-serine and acquire A1 reactive astrocyte features. Biochem Pharmacol. 2018 Jan 03. PMID: 29305854.
    View in: PubMed
  2. Benham RS, Hewage NB, Suckow RF, Engin E, Rudolph U. Corrigendum to "Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking a2-containing GABAA receptors" [Behav. Brain Res. 332 (2017) 172-179]. Behav Brain Res. 2018 Feb 15; 338:186-189. PMID: 29070432.
    View in: PubMed
  3. Balk M, Hentschke H, Rudolph U, Antkowiak B, Drexler B. Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices. Sci Rep. 2017 Jun 14; 7(1):3503. PMID: 28615640.
    View in: PubMed
  4. Benham RS, Hewage NB, Suckow RF, Engin E, Rudolph U. Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking a2-containing GABAA receptors. Behav Brain Res. 2017 08 14; 332:172-179. PMID: 28587819.
    View in: PubMed
  5. Tcw J, Carvalho CM, Yuan B, Gu S, Altheimer AN, McCarthy S, Malhotra D, Sebat J, Siegel AJ, Rudolph U, Lupski JR, Levy DL, Brennand KJ. Divergent Levels of Marker Chromosomes in an hiPSC-Based Model of Psychosis. Stem Cell Reports. 2017 03 14; 8(3):519-528. PMID: 28216146.
    View in: PubMed
  6. Möhler H, Rudolph U. Disinhibition, an emerging pharmacology of learning and memory. F1000Res. 2017; 6. PMID: 28232865.
    View in: PubMed
  7. Newman EL, Gunner G, Huynh P, Gachette D, Moss SJ, Smart TG, Rudolph U, DeBold JF, Miczek KA. Effects of Gabra2 Point Mutations on Alcohol Intake: Increased Binge-Like and Blunted Chronic Drinking by Mice. Alcohol Clin Exp Res. 2016 Nov; 40(11):2445-2455. PMID: 27717041.
    View in: PubMed
  8. Antkowiak B, Rudolph U. New insights in the systemic and molecular underpinnings of general anesthetic actions mediated by ?-aminobutyric acid A receptors. Curr Opin Anaesthesiol. 2016 Aug; 29(4):447-53. PMID: 27168087; PMCID: PMC4957807 [Available on 08/01/17].
  9. Deprez F, Vogt F, Floriou-Servou A, Lafourcade C, Rudolph U, Tyagarajan SK, Fritschy JM. Partial inactivation of GABAA receptors containing the a5 subunit affects the development of adult-born dentate gyrus granule cells. Eur J Neurosci. 2016 Sep; 44(5):2258-71. PMID: 27364953; PMCID: PMC5012961 [Available on 09/01/17].
  10. Ralvenius WT, Acuña MA, Benke D, Matthey A, Daali Y, Rudolph U, Desmeules J, Zeilhofer HU, Besson M. The clobazam metabolite N-desmethyl clobazam is an a2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia. Neuropharmacology. 2016 10; 109:366-375. PMID: 27392635; PMCID: PMC4981430 [Available on 10/01/16].
  11. Behlke LM, Foster RA, Liu J, Benke D, Benham RS, Nathanson AJ, Yee BK, Zeilhofer HU, Engin E, Rudolph U. A Pharmacogenetic 'Restriction-of-Function' Approach Reveals Evidence for Anxiolytic-Like Actions Mediated by a5-Containing GABAA Receptors in Mice. Neuropsychopharmacology. 2016 09; 41(10):2492-501. PMID: 27067130; PMCID: PMC4987847 [Available on 09/01/17].
  12. Engin E, Smith KS, Gao Y, Nagy D, Foster RA, Tsvetkov E, Keist R, Crestani F, Fritschy JM, Bolshakov VY, Hajos M, Heldt SA, Rudolph U. Modulation of anxiety and fear via distinct intrahippocampal circuits. Elife. 2016 Mar 14; 5:e14120. PMID: 26971710; PMCID: PMC4816644.
  13. Pangratz-Fuehrer S, Sieghart W, Rudolph U, Parada I, Huguenard JR. Early postnatal switch in GABAA receptor a-subunits in the reticular thalamic nucleus. J Neurophysiol. 2016 Mar; 115(3):1183-95. PMID: 26631150; PMCID: PMC4808120 [Available on 03/01/17].
  14. Botta P, Demmou L, Kasugai Y, Markovic M, Xu C, Fadok JP, Lu T, Poe MM, Xu L, Cook JM, Rudolph U, Sah P, Ferraguti F, Lüthi A. Corrigendum: Regulating anxiety with extrasynaptic inhibition. Nat Neurosci. 2015 Dec; 18(12):1862. PMID: 26605888.
    View in: PubMed
  15. Vien TN, Modgil A, Abramian AM, Jurd R, Walker J, Brandon NJ, Terunuma M, Rudolph U, Maguire J, Davies PA, Moss SJ. Compromising the phosphodependent regulation of the GABAAR ß3 subunit reproduces the core phenotypes of autism spectrum disorders. Proc Natl Acad Sci U S A. 2015 Dec 01; 112(48):14805-10. PMID: 26627235; PMCID: PMC4672772.
  16. Engin E, Zarnowska ED, Benke D, Tsvetkov E, Sigal M, Keist R, Bolshakov VY, Pearce RA, Rudolph U. Tonic Inhibitory Control of Dentate Gyrus Granule Cells by a5-Containing GABAA Receptors Reduces Memory Interference. J Neurosci. 2015 Oct 07; 35(40):13698-712. PMID: 26446222; PMCID: PMC4595621.
  17. Newman EL, Smith KS, Takahashi A, Chu A, Hwa LS, Chen Y, DeBold JF, Rudolph U, Miczek KA. a2-containing GABA(A) receptors: a requirement for midazolam-escalated aggression and social approach in mice. Psychopharmacology (Berl). 2015 Dec; 232(23):4359-69. PMID: 26381154; PMCID: PMC4618782 [Available on 12/01/16].
  18. Botta P, Demmou L, Kasugai Y, Markovic M, Xu C, Fadok JP, Lu T, Poe MM, Xu L, Cook JM, Rudolph U, Sah P, Ferraguti F, Lüthi A. Regulating anxiety with extrasynaptic inhibition. Nat Neurosci. 2015 Oct; 18(10):1493-500. PMID: 26322928; PMCID: PMC4607767.
  19. Rodgers FC, Zarnowska ED, Laha KT, Engin E, Zeller A, Keist R, Rudolph U, Pearce RA. Etomidate Impairs Long-Term Potentiation In Vitro by Targeting a5-Subunit Containing GABAA Receptors on Nonpyramidal Cells. J Neurosci. 2015 Jul 01; 35(26):9707-16. PMID: 26134653; PMCID: PMC4571505.
  20. Ralvenius WT, Benke D, Acuña MA, Rudolph U, Zeilhofer HU. Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype. Nat Commun. 2015 Apr 13; 6:6803. PMID: 25865415; PMCID: PMC4829939.
  21. Zarnowska ED, Rodgers FC, Oh I, Rau V, Lor C, Laha KT, Jurd R, Rudolph U, Eger EI, Pearce RA. Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABA(A) receptor. Neuropharmacology. 2015 Jun; 93:171-178. PMID: 25680234; PMCID: PMC4387092.
  22. Rudolph U, Enna SJ. Preface: A tribute to professor Hanns Möhler. Adv Pharmacol. 2015; 73:ix-xii. PMID: 25637444.
    View in: PubMed
  23. Rudolph U, Enna SJ. Preface: a tribute to professor Hanns Möhler. Adv Pharmacol. 2015; 72:ix-xii. PMID: 25600374.
    View in: PubMed
  24. Labrakakis C, Rudolph U, De Koninck Y. The heterogeneity in GABAA receptor-mediated IPSC kinetics reflects heterogeneity of subunit composition among inhibitory and excitatory interneurons in spinal lamina II. Front Cell Neurosci. 2014; 8:424. PMID: 25565959; PMCID: PMC4263102.
  25. Crestani F, Rudolph U. Behavioral functions of GABAA receptor subtypes--the Zurich experience. Adv Pharmacol. 2015; 72:37-51. PMID: 25600366.
    View in: PubMed
  26. Martin CB, Gassmann M, Chevarin C, Hamon M, Rudolph U, Bettler B, Lanfumey L, Mongeau R. Effect of genetic and pharmacological blockade of GABA receptors on the 5-HT2C receptor function during stress. J Neurochem. 2014 Dec; 131(5):566-72. PMID: 25113583; PMCID: PMC4237664.
  27. Eckle VS, Rudolph U, Antkowiak B, Grasshoff C. Propofol modulates phasic and tonic GABAergic currents in spinal ventral horn interneurones. Br J Anaesth. 2015 Mar; 114(3):491-8. PMID: 25150989.
    View in: PubMed
  28. Seifi M, Brown JF, Mills J, Bhandari P, Belelli D, Lambert JJ, Rudolph U, Swinny JD. Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. J Neurosci. 2014 Jul 30; 34(31):10361-78. PMID: 25080596; PMCID: PMC4115141.
  29. Corteen NL, Carter JA, Rudolph U, Belelli D, Lambert JJ, Swinny JD. Localisation and stress-induced plasticity of GABAA receptor subunits within the cellular networks of the mouse dorsal raphe nucleus. Brain Struct Funct. 2015 Sep; 220(5):2739-63. PMID: 24973971.
    View in: PubMed
  30. Riccio A, Li Y, Tsvetkov E, Gapon S, Yao GL, Smith KS, Engin E, Rudolph U, Bolshakov VY, Clapham DE. Decreased anxiety-like behavior and Gaq/11-dependent responses in the amygdala of mice lacking TRPC4 channels. J Neurosci. 2014 Mar 05; 34(10):3653-67. PMID: 24599464; PMCID: PMC3942581.
  31. Engin E, Bakhurin KI, Smith KS, Hines RM, Reynolds LM, Tang W, Sprengel R, Moss SJ, Rudolph U. Neural basis of benzodiazepine reward: requirement for a2 containing GABAA receptors in the nucleus accumbens. Neuropsychopharmacology. 2014 Jul; 39(8):1805-15. PMID: 24553732; PMCID: PMC4059902.
  32. Benham RS, Engin E, Rudolph U. Diversity of neuronal inhibition: a path to novel treatments for neuropsychiatric disorders. JAMA Psychiatry. 2014 Jan; 71(1):91-3. PMID: 24196284; PMCID: PMC3997169.
  33. Licata SC, Shinday NM, Huizenga MN, Darnell SB, Sangrey GR, Rudolph U, Rowlett JK, Sadri-Vakili G. Alterations in brain-derived neurotrophic factor in the mouse hippocampus following acute but not repeated benzodiazepine treatment. PLoS One. 2013; 8(12):e84806. PMID: 24367698; PMCID: PMC3868703.
  34. Rudolph U, Möhler H. GABAA receptor subtypes: Therapeutic potential in Down syndrome, affective disorders, schizophrenia, and autism. Annu Rev Pharmacol Toxicol. 2014; 54:483-507. PMID: 24160694; PMCID: PMC3997216.
  35. Paul J, Yévenes GE, Benke D, Di Lio A, Ralvenius WT, Witschi R, Scheurer L, Cook JM, Rudolph U, Fritschy JM, Zeilhofer HU. Antihyperalgesia by a2-GABAA receptors occurs via a genuine spinal action and does not involve supraspinal sites. Neuropsychopharmacology. 2014 Jan; 39(2):477-87. PMID: 24045508; PMCID: PMC3870792.
  36. Christian CA, Herbert AG, Holt RL, Peng K, Sherwood KD, Pangratz-Fuehrer S, Rudolph U, Huguenard JR. Endogenous positive allosteric modulation of GABA(A) receptors by diazepam binding inhibitor. Neuron. 2013 Jun 19; 78(6):1063-74. PMID: 23727119; PMCID: PMC3987987.
  37. Straub CJ, Lau HM, Parlato R, Schuetz G, Fritschy JM, Rudolph U. Bidirectional regulation of intravenous general anesthetic actions by a3-containing ?-aminobutyric acid A receptors. Anesthesiology. 2013 Mar; 118(3):562-76. PMID: 23303487; PMCID: PMC3951843.
  38. Van't Veer A, Bechtholt AJ, Onvani S, Potter D, Wang Y, Liu-Chen LY, Schütz G, Chartoff EH, Rudolph U, Cohen BM, Carlezon WA. Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity. Neuropsychopharmacology. 2013 Jul; 38(8):1585-97. PMID: 23446450; PMCID: PMC3682153.
  39. Ohtsuka N, Badurek S, Busslinger M, Benes FM, Minichiello L, Rudolph U. GABAergic neurons regulate lateral ventricular development via transcription factor Pax5. Genesis. 2013 Apr; 51(4):234-45. PMID: 23349049; PMCID: PMC3740952.
  40. Drexler B, Zinser S, Huang S, Poe MM, Rudolph U, Cook JM, Antkowiak B. Enhancing the function of alpha5-subunit-containing GABAA receptors promotes action potential firing of neocortical neurons during up-states. Eur J Pharmacol. 2013 Mar 05; 703(1-3):18-24. PMID: 23380687; PMCID: PMC3996676.
  41. Blednov YA, Benavidez JM, Black M, Chandra D, Homanics GE, Rudolph U, Harris RA. Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication. Neuropharmacology. 2013 Apr; 67:46-56. PMID: 23147414; PMCID: PMC3562427.
  42. Koester C, Rudolph U, Haenggi T, Papilloud A, Fritschy JM, Crestani F. Dissecting the role of diazepam-sensitive ?-aminobutyric acid type A receptors in defensive behavioral reactivity to mild threat. Pharmacol Biochem Behav. 2013 Jan; 103(3):541-9. PMID: 23067879.
    View in: PubMed
  43. Engin E, Liu J, Rudolph U. a2-containing GABA(A) receptors: a target for the development of novel treatment strategies for CNS disorders. Pharmacol Ther. 2012 Nov; 136(2):142-52. PMID: 22921455; PMCID: PMC3478960.
  44. Reynolds LM, Engin E, Tantillo G, Lau HM, Muschamp JW, Carlezon WA, Rudolph U. Differential roles of GABA(A) receptor subtypes in benzodiazepine-induced enhancement of brain-stimulation reward. Neuropsychopharmacology. 2012 Oct; 37(11):2531-40. PMID: 22763624; PMCID: PMC3442348.
  45. Pallotto M, Nissant A, Fritschy JM, Rudolph U, Sassoè-Pognetto M, Panzanelli P, Lledo PM. Early formation of GABAergic synapses governs the development of adult-born neurons in the olfactory bulb. J Neurosci. 2012 Jun 27; 32(26):9103-15. PMID: 22745509.
    View in: PubMed
  46. Marowsky A, Rudolph U, Fritschy JM, Arand M. Tonic inhibition in principal cells of the amygdala: a central role for a3 subunit-containing GABAA receptors. J Neurosci. 2012 Jun 20; 32(25):8611-9. PMID: 22723702.
    View in: PubMed
  47. Auferkorte ON, Baden T, Kaushalya SK, Zabouri N, Rudolph U, Haverkamp S, Euler T. GABA(A) receptors containing the a2 subunit are critical for direction-selective inhibition in the retina. PLoS One. 2012; 7(4):e35109. PMID: 22506070; PMCID: PMC3323634.
  48. Smith KS, Engin E, Meloni EG, Rudolph U. Benzodiazepine-induced anxiolysis and reduction of conditioned fear are mediated by distinct GABAA receptor subtypes in mice. Neuropharmacology. 2012 Aug; 63(2):250-8. PMID: 22465203; PMCID: PMC3372637.
  49. Lalive AL, Rudolph U, Lüscher C, Tan KR. Is there a way to curb benzodiazepine addiction? Swiss Med Wkly. 2011 Oct 19; 141:w13277. PMID: 22012428.
    View in: PubMed
  50. Panzanelli P, Gunn BG, Schlatter MC, Benke D, Tyagarajan SK, Scheiffele P, Belelli D, Lambert JJ, Rudolph U, Fritschy JM. Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells. J Physiol. 2011 Oct 15; 589(Pt 20):4959-80. PMID: 21825022; PMCID: PMC3224886.
  51. Rudolph U, Knoflach F. Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes. Nat Rev Drug Discov. 2011 Jul 29; 10(9):685-97. PMID: 21799515; PMCID: PMC3375401.
  52. Smith KS, Rudolph U. Anxiety and depression: mouse genetics and pharmacological approaches to the role of GABA(A) receptor subtypes. Neuropharmacology. 2012 Jan; 62(1):54-62. PMID: 21810433; PMCID: PMC3340889.
  53. Bähner F, Weiss EK, Birke G, Maier N, Schmitz D, Rudolph U, Frotscher M, Traub RD, Both M, Draguhn A. Cellular correlate of assembly formation in oscillating hippocampal networks in vitro. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):E607-16. PMID: 21768381; PMCID: PMC3167520.
  54. Yanovsky Y, Schubring S, Fleischer W, Gisselmann G, Zhu XR, Lübbert H, Hatt H, Rudolph U, Haas HL, Sergeeva OA. GABAA receptors involved in sleep and anaesthesia: ß1- versus ß3-containing assemblies. Pflugers Arch. 2012 Jan; 463(1):187-99. PMID: 21735059.
    View in: PubMed
  55. Duveau V, Laustela S, Barth L, Gianolini F, Vogt KE, Keist R, Chandra D, Homanics GE, Rudolph U, Fritschy JM. Spatiotemporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis. Eur J Neurosci. 2011 Aug; 34(3):362-73. PMID: 21722213; PMCID: PMC3996709.
  56. Witschi R, Punnakkal P, Paul J, Walczak JS, Cervero F, Fritschy JM, Kuner R, Keist R, Rudolph U, Zeilhofer HU. Presynaptic alpha2-GABAA receptors in primary afferent depolarization and spinal pain control. J Neurosci. 2011 Jun 01; 31(22):8134-42. PMID: 21632935; PMCID: PMC3567284.
  57. Tan KR, Rudolph U, Lüscher C. Hooked on benzodiazepines: GABAA receptor subtypes and addiction. Trends Neurosci. 2011 Apr; 34(4):188-97. PMID: 21353710; PMCID: PMC4020178.
  58. Drexler B, Antkowiak B, Engin E, Rudolph U. Identification and characterization of anesthetic targets by mouse molecular genetics approaches. Can J Anaesth. 2011 Feb; 58(2):178-90. PMID: 21174184; PMCID: PMC3330822.
  59. Vollenweider I, Smith KS, Keist R, Rudolph U. Antidepressant-like properties of a2-containing GABA(A) receptors. Behav Brain Res. 2011 Feb 02; 217(1):77-80. PMID: 20965216; PMCID: PMC3023881.
  60. Smith KS, Meloni EG, Myers KM, Van't Veer A, Carlezon WA, Rudolph U. Reduction of fear-potentiated startle by benzodiazepines in C57BL/6J mice. Psychopharmacology (Berl). 2011 Feb; 213(4):697-706. PMID: 20922362; PMCID: PMC3056161.
  61. Butovas S, Rudolph U, Jurd R, Schwarz C, Antkowiak B. Activity patterns in the prefrontal cortex and hippocampus during and after awakening from etomidate anesthesia. Anesthesiology. 2010 Jul; 113(1):48-57. PMID: 20508498.
    View in: PubMed
  62. Tan KR, Brown M, Labouèbe G, Yvon C, Creton C, Fritschy JM, Rudolph U, Lüscher C. Neural bases for addictive properties of benzodiazepines. Nature. 2010 Feb 11; 463(7282):769-74. PMID: 20148031; PMCID: PMC2871668.
  63. Straub CJ, Carlezon WA, Rudolph U. Diazepam and cocaine potentiate brain stimulation reward in C57BL/6J mice. Behav Brain Res. 2010 Jan 05; 206(1):17-20. PMID: 19716385.
    View in: PubMed
  64. Li P, Rudolph U, Huntsman MM. Long-term sensory deprivation selectively rearranges functional inhibitory circuits in mouse barrel cortex. Proc Natl Acad Sci U S A. 2009 Jul 21; 106(29):12156-61. PMID: 19584253; PMCID: PMC2706689.
  65. Drexler B, Jurd R, Rudolph U, Antkowiak B. Distinct actions of etomidate and propofol at beta3-containing gamma-aminobutyric acid type A receptors. Neuropharmacology. 2009 Sep; 57(4):446-55. PMID: 19555700.
    View in: PubMed
  66. Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. 2009 May 15; 137(4):761-72. PMID: 19450521; PMCID: PMC2719954.
  67. Balic E, Rudolph U, Fritschy JM, Mohler H, Benke D. The alpha5(H105R) mutation impairs alpha5 selective binding properties by altered positioning of the alpha5 subunit in GABAA receptors containing two distinct types of alpha subunits. J Neurochem. 2009 Jul; 110(1):244-54. PMID: 19457072.
    View in: PubMed
  68. Schofield CM, Kleiman-Weiner M, Rudolph U, Huguenard JR. A gain in GABAA receptor synaptic strength in thalamus reduces oscillatory activity and absence seizures. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7630-5. PMID: 19380748; PMCID: PMC2678654.
  69. Zecharia AY, Nelson LE, Gent TC, Schumacher M, Jurd R, Rudolph U, Brickley SG, Maze M, Franks NP. The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse. J Neurosci. 2009 Feb 18; 29(7):2177-87. PMID: 19228970.
    View in: PubMed
  70. Knabl J, Zeilhofer UB, Crestani F, Rudolph U, Zeilhofer HU. Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice. Pain. 2009 Feb; 141(3):233-8. PMID: 19091469.
    View in: PubMed
  71. Zarnowska ED, Keist R, Rudolph U, Pearce RA. GABAA receptor alpha5 subunits contribute to GABAA,slow synaptic inhibition in mouse hippocampus. J Neurophysiol. 2009 Mar; 101(3):1179-91. PMID: 19073796; PMCID: PMC2666407.
  72. Fiorelli R, Rudolph U, Straub CJ, Feldon J, Yee BK. Affective and cognitive effects of global deletion of alpha3-containing gamma-aminobutyric acid-A receptors. Behav Pharmacol. 2008 Sep; 19(5-6):582-96. PMID: 18690113.
    View in: PubMed
  73. Benke D, Barberis A, Kopp S, Altmann KH, Schubiger M, Vogt KE, Rudolph U, Möhler H. GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology. 2009 Jan; 56(1):174-81. PMID: 18602406.
    View in: PubMed
  74. Winsky-Sommerer R, Knapman A, Fedele DE, Schofield CM, Vyazovskiy VV, Rudolph U, Huguenard JR, Fritschy JM, Tobler I. Normal sleep homeostasis and lack of epilepsy phenotype in GABA A receptor alpha3 subunit-knockout mice. Neuroscience. 2008 Jun 23; 154(2):595-605. PMID: 18485607; PMCID: PMC2587445.
  75. Möhler H, Rudolph U, Boison D, Singer P, Feldon J, Yee BK. Regulation of cognition and symptoms of psychosis: focus on GABA(A) receptors and glycine transporter 1. Pharmacol Biochem Behav. 2008 Jul; 90(1):58-64. PMID: 18455219.
    View in: PubMed
  76. Knabl J, Witschi R, Hösl K, Reinold H, Zeilhofer UB, Ahmadi S, Brockhaus J, Sergejeva M, Hess A, Brune K, Fritschy JM, Rudolph U, Möhler H, Zeilhofer HU. Reversal of pathological pain through specific spinal GABAA receptor subtypes. Nature. 2008 Jan 17; 451(7176):330-4. PMID: 18202657.
    View in: PubMed
  77. Zeller A, Jurd R, Lambert S, Arras M, Drexler B, Grashoff C, Antkowiak B, Rudolph U. Inhibitory ligand-gated ion channels as substrates for general anesthetic actions. Handb Exp Pharmacol. 2008; (182):31-51. PMID: 18175085.
    View in: PubMed
  78. Zeller A, Crestani F, Camenisch I, Iwasato T, Itohara S, Fritschy JM, Rudolph U. Cortical glutamatergic neurons mediate the motor sedative action of diazepam. Mol Pharmacol. 2008 Feb; 73(2):282-91. PMID: 17965197.
    View in: PubMed
  79. Gerdjikov TV, Rudolph U, Keist R, Möhler H, Feldon J, Yee BK. Hippocampal alpha 5 subunit-containing GABA A receptors are involved in the development of the latent inhibition effect. Neurobiol Learn Mem. 2008 Feb; 89(2):87-94. PMID: 17638582.
    View in: PubMed
  80. Grasshoff C, Jurd R, Rudolph U, Antkowiak B. Modulation of presynaptic beta3-containing GABAA receptors limits the immobilizing actions of GABAergic anesthetics. Mol Pharmacol. 2007 Sep; 72(3):780-7. PMID: 17584992.
    View in: PubMed
  81. Zeller A, Arras M, Jurd R, Rudolph U. Mapping the contribution of beta3-containing GABAA receptors to volatile and intravenous general anesthetic actions. BMC Pharmacol. 2007 Feb 24; 7:2. PMID: 17319964; PMCID: PMC1810244.
  82. Sanchis-Segura C, Cline B, Jurd R, Rudolph U, Spanagel R. Etomidate and propofol-hyposensitive GABAA receptor beta3(N265M) mice show little changes in acute alcohol sensitivity but enhanced tolerance and withdrawal. Neurosci Lett. 2007 Apr 18; 416(3):275-8. PMID: 17350761.
    View in: PubMed
  83. Pangratz-Fuehrer S, Rudolph U, Huguenard JR. Giant spontaneous depolarizing potentials in the developing thalamic reticular nucleus. J Neurophysiol. 2007 Mar; 97(3):2364-72. PMID: 17251370.
    View in: PubMed
  84. Zeller A, Arras M, Jurd R, Rudolph U. Identification of a molecular target mediating the general anesthetic actions of pentobarbital. Mol Pharmacol. 2007 Mar; 71(3):852-9. PMID: 17164405.
    View in: PubMed
  85. Studer R, von Boehmer L, Haenggi T, Schweizer C, Benke D, Rudolph U, Fritschy JM. Alteration of GABAergic synapses and gephyrin clusters in the thalamic reticular nucleus of GABAA receptor alpha3 subunit-null mice. Eur J Neurosci. 2006 Sep; 24(5):1307-15. PMID: 16987218.
    View in: PubMed
  86. Prenosil GA, Schneider Gasser EM, Rudolph U, Keist R, Fritschy JM, Vogt KE. Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons. J Neurophysiol. 2006 Aug; 96(2):846-57. PMID: 16835366.
    View in: PubMed
  87. Merrill AW, Barter LS, Rudolph U, Eger EI, Antognini JF, Carstens MI, Carstens E. Propofol's effects on nociceptive behavior and spinal c-fos expression after intraplantar formalin injection in mice with a mutation in the gamma-aminobutyric acid-type(A) receptor beta3 subunit. Anesth Analg. 2006 Aug; 103(2):478-83, table of contents. PMID: 16861438.
    View in: PubMed
  88. Drexler B, Jurd R, Rudolph U, Antkowiak B. Dual actions of enflurane on postsynaptic currents abolished by the gamma-aminobutyric acid type A receptor beta3(N265M) point mutation. Anesthesiology. 2006 Aug; 105(2):297-304. PMID: 16871063.
    View in: PubMed
  89. Sohal VS, Pangratz-Fuehrer S, Rudolph U, Huguenard JR. Intrinsic and synaptic dynamics interact to generate emergent patterns of rhythmic bursting in thalamocortical neurons. J Neurosci. 2006 Apr 19; 26(16):4247-55. PMID: 16624945.
    View in: PubMed
  90. Drexler B, Grasshoff C, Rudolph U, Unertl K, Antkowiak B. [The GABA(A) receptor family: possibilities for the development of better anesthetics]. Anaesthesist. 2006 Mar; 55(3):287-95. PMID: 16315024.
    View in: PubMed
  91. Grasshoff C, Drexler B, Rudolph U, Antkowiak B. Anaesthetic drugs: linking molecular actions to clinical effects. Curr Pharm Des. 2006; 12(28):3665-79. PMID: 17073666.
    View in: PubMed
  92. Rudolph U, Möhler H. GABA-based therapeutic approaches: GABAA receptor subtype functions. Curr Opin Pharmacol. 2006 Feb; 6(1):18-23. PMID: 16376150.
    View in: PubMed
  93. Yee BK, Keist R, von Boehmer L, Studer R, Benke D, Hagenbuch N, Dong Y, Malenka RC, Fritschy JM, Bluethmann H, Feldon J, Möhler H, Rudolph U. A schizophrenia-related sensorimotor deficit links alpha 3-containing GABAA receptors to a dopamine hyperfunction. Proc Natl Acad Sci U S A. 2005 Nov 22; 102(47):17154-9. PMID: 16284244; PMCID: PMC1288020.
  94. Liao M, Sonner JM, Jurd R, Rudolph U, Borghese CM, Harris RA, Laster MJ, Eger EI. Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane. Anesth Analg. 2005 Aug; 101(2):412-8, table of contents. PMID: 16037154.
    View in: PubMed
  95. Grasshoff C, Rudolph U, Antkowiak B. Molecular and systemic mechanisms of general anaesthesia: the 'multi-site and multiple mechanisms' concept. Curr Opin Anaesthesiol. 2005 Aug; 18(4):386-91. PMID: 16534263.
    View in: PubMed
  96. Zeller A, Arras M, Lazaris A, Jurd R, Rudolph U. Distinct molecular targets for the central respiratory and cardiac actions of the general anesthetics etomidate and propofol. FASEB J. 2005 Oct; 19(12):1677-9. PMID: 16046472.
    View in: PubMed
  97. Liao M, Sonner JM, Husain SS, Miller KW, Jurd R, Rudolph U, Eger EI. R (+) etomidate and the photoactivable R (+) azietomidate have comparable anesthetic activity in wild-type mice and comparably decreased activity in mice with a N265M point mutation in the gamma-aminobutyric acid receptor beta3 subunit. Anesth Analg. 2005 Jul; 101(1):131-5, table of contents. PMID: 15976219.
    View in: PubMed
  98. Lambert S, Arras M, Vogt KE, Rudolph U. Isoflurane-induced surgical tolerance mediated only in part by beta3-containing GABA(A) receptors. Eur J Pharmacol. 2005 May 23; 516(1):23-7. PMID: 15913600.
    View in: PubMed
  99. Hauser J, Rudolph U, Keist R, Möhler H, Feldon J, Yee BK. Hippocampal alpha5 subunit-containing GABAA receptors modulate the expression of prepulse inhibition. Mol Psychiatry. 2005 Feb; 10(2):201-7. PMID: 15263904.
    View in: PubMed
  100. Drexler B, Roether CL, Jurd R, Rudolph U, Antkowiak B. Opposing actions of etomidate on cortical theta oscillations are mediated by different gamma-aminobutyric acid type A receptor subtypes. Anesthesiology. 2005 Feb; 102(2):346-52. PMID: 15681950.
    View in: PubMed
  101. Möhler H, Fritschy JM, Vogt K, Crestani F, Rudolph U. Pathophysiology and pharmacology of GABA(A) receptors. Handb Exp Pharmacol. 2005; (169):225-47. PMID: 16594261.
    View in: PubMed
  102. Möhler H, Fritschy JM, Crestani F, Hensch T, Rudolph U. Specific GABA(A) circuits in brain development and therapy. Biochem Pharmacol. 2004 Oct 15; 68(8):1685-90. PMID: 15451412.
    View in: PubMed
  103. Kopp C, Rudolph U, Tobler I. Sleep EEG changes after zolpidem in mice. Neuroreport. 2004 Oct 05; 15(14):2299-302. PMID: 15371753.
    View in: PubMed
  104. Yee BK, Hauser J, Dolgov VV, Keist R, Möhler H, Rudolph U, Feldon J. GABA receptors containing the alpha5 subunit mediate the trace effect in aversive and appetitive conditioning and extinction of conditioned fear. Eur J Neurosci. 2004 Oct; 20(7):1928-36. PMID: 15380015.
    View in: PubMed
  105. Rudolph U, Antkowiak B. Molecular and neuronal substrates for general anaesthetics. Nat Rev Neurosci. 2004 Sep; 5(9):709-20. PMID: 15322529.
    View in: PubMed
  106. Benke D, Fakitsas P, Roggenmoser C, Michel C, Rudolph U, Mohler H. Analysis of the presence and abundance of GABAA receptors containing two different types of alpha subunits in murine brain using point-mutated alpha subunits. J Biol Chem. 2004 Oct 15; 279(42):43654-60. PMID: 15304513.
    View in: PubMed
  107. van Rijnsoever C, Täuber M, Choulli MK, Keist R, Rudolph U, Mohler H, Fritschy JM, Crestani F. Requirement of alpha5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice. J Neurosci. 2004 Jul 28; 24(30):6785-90. PMID: 15282283.
    View in: PubMed
  108. Fagiolini M, Fritschy JM, Löw K, Möhler H, Rudolph U, Hensch TK. Specific GABAA circuits for visual cortical plasticity. Science. 2004 Mar 12; 303(5664):1681-3. PMID: 15017002.
    View in: PubMed
  109. Huopaniemi L, Keist R, Randolph A, Certa U, Rudolph U. Diazepam-induced adaptive plasticity revealed by alpha1 GABAA receptor-specific expression profiling. J Neurochem. 2004 Mar; 88(5):1059-67. PMID: 15009662.
    View in: PubMed
  110. Kopp C, Rudolph U, Löw K, Tobler I. Modulation of rhythmic brain activity by diazepam: GABA(A) receptor subtype and state specificity. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3674-9. PMID: 14990800; PMCID: PMC373521.
  111. Kosel M, Rudolph U, Wielepp P, Luginbühl M, Schmitt W, Fisch HU, Schlaepfer TE. Diminished GABA(A) receptor-binding capacity and a DNA base substitution in a patient with treatment-resistant depression and anxiety. Neuropsychopharmacology. 2004 Feb; 29(2):347-50. PMID: 14628001.
    View in: PubMed
  112. Rudolph U, Möhler H. Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics. Annu Rev Pharmacol Toxicol. 2004; 44:475-98. PMID: 14744255.
    View in: PubMed
  113. Siegwart R, Krähenbühl K, Lambert S, Rudolph U. Mutational analysis of molecular requirements for the actions of general anaesthetics at the gamma-aminobutyric acidA receptor subtype, alpha1beta2gamma2. BMC Pharmacol. 2003 Nov 12; 3:13. PMID: 14613517; PMCID: PMC280653.
  114. Täuber M, Calame-Droz E, Prut L, Rudolph U, Crestani F. alpha2-gamma-Aminobutyric acid (GABA)A receptors are the molecular substrates mediating precipitation of narcosis but not of sedation by the combined use of diazepam and alcohol in vivo. Eur J Neurosci. 2003 Nov; 18(9):2599-604. PMID: 14622161.
    View in: PubMed
  115. Bacci A, Rudolph U, Huguenard JR, Prince DA. Major differences in inhibitory synaptic transmission onto two neocortical interneuron subclasses. J Neurosci. 2003 Oct 22; 23(29):9664-74. PMID: 14573546.
    View in: PubMed
  116. Wieser HG, Rudolph U, Blau N, Boison D, Imhof HG, Bernays R, Yonekawa Y. Amino acid composition of brain cysts: levels of excitatory amino acids in cyst fluid fail to predict seizures. Epilepsy Res. 2003 Aug; 55(3):191-9. PMID: 12972173.
    View in: PubMed
  117. Kopp C, Rudolph U, Keist R, Tobler I. Diazepam-induced changes on sleep and the EEG spectrum in mice: role of the alpha3-GABA(A) receptor subtype. Eur J Neurosci. 2003 May; 17(10):2226-30. PMID: 12786990.
    View in: PubMed
  118. Sohal VS, Keist R, Rudolph U, Huguenard JR. Dynamic GABA(A) receptor subtype-specific modulation of the synchrony and duration of thalamic oscillations. J Neurosci. 2003 May 01; 23(9):3649-57. PMID: 12736336.
    View in: PubMed
  119. Jurd R, Arras M, Lambert S, Drexler B, Siegwart R, Crestani F, Zaugg M, Vogt KE, Ledermann B, Antkowiak B, Rudolph U. General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit. FASEB J. 2003 Feb; 17(2):250-2. PMID: 12475885.
    View in: PubMed
  120. Crestani F, Assandri R, Täuber M, Martin JR, Rudolph U. Contribution of the alpha1-GABA(A) receptor subtype to the pharmacological actions of benzodiazepine site inverse agonists. Neuropharmacology. 2002 Sep; 43(4):679-84. PMID: 12367613.
    View in: PubMed
  121. Ohman L, Franzén L, Rudolph U, Birnbaumer L, Hörnquist EH. Regression of Peyer's patches in G alpha i2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis. Gut. 2002 Sep; 51(3):392-7. PMID: 12171962; PMCID: PMC1773369.
  122. Crestani F, Keist R, Fritschy JM, Benke D, Vogt K, Prut L, Blüthmann H, Möhler H, Rudolph U. Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8980-5. PMID: 12084936; PMCID: PMC124409.
  123. Jiang M, Spicher K, Boulay G, Martín-Requero A, Dye CA, Rudolph U, Birnbaumer L. Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteins. Methods Enzymol. 2002; 344:277-98. PMID: 11771389.
    View in: PubMed
  124. Siegwart R, Jurd R, Rudolph U. Molecular determinants for the action of general anesthetics at recombinant alpha(2)beta(3)gamma(2)gamma-aminobutyric acid(A) receptors. J Neurochem. 2002 Jan; 80(1):140-8. PMID: 11796752.
    View in: PubMed
  125. Möhler H, Fritschy JM, Rudolph U. A new benzodiazepine pharmacology. J Pharmacol Exp Ther. 2002 Jan; 300(1):2-8. PMID: 11752090.
    View in: PubMed
  126. Uhlig HH, Hultgren Hörnquist E, Ohman Bache L, Rudolph U, Birnbaumer L, Mothes T. Antibody response to dietary and autoantigens in G alpha i2-deficient mice. Eur J Gastroenterol Hepatol. 2001 Dec; 13(12):1421-9. PMID: 11742190.
    View in: PubMed
  127. Tobler I, Kopp C, Deboer T, Rudolph U. Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtype. Proc Natl Acad Sci U S A. 2001 May 22; 98(11):6464-9. PMID: 11353839; PMCID: PMC33491.
  128. Rudolph U. Identification of molecular substrate for the attenuation of anxiety: a step toward the development of better anti-anxiety drugs. ScientificWorldJournal. 2001 May 01; 1:192-3. PMID: 12805666.
    View in: PubMed
  129. Rudolph U, Crestani F, Möhler H. GABA(A) receptor subtypes: dissecting their pharmacological functions. Trends Pharmacol Sci. 2001 Apr; 22(4):188-94. PMID: 11282419.
    View in: PubMed
  130. Crestani F, Löw K, Keist R, Mandelli M, Möhler H, Rudolph U. Molecular targets for the myorelaxant action of diazepam. Mol Pharmacol. 2001 Mar; 59(3):442-5. PMID: 11179437.
    View in: PubMed
  131. Möhler H, Crestani F, Rudolph U. GABA(A)-receptor subtypes: a new pharmacology. Curr Opin Pharmacol. 2001 Feb; 1(1):22-5. PMID: 11712530.
    View in: PubMed
  132. Crestani F, Martin JR, Möhler H, Rudolph U. Mechanism of action of the hypnotic zolpidem in vivo. Br J Pharmacol. 2000 Dec; 131(7):1251-4. PMID: 11090095; PMCID: PMC1572473.
  133. Crestani F, Martin JR, Möhler H, Rudolph U. Resolving differences in GABAA receptor mutant mouse studies. Nat Neurosci. 2000 Nov; 3(11):1059. PMID: 11036253.
    View in: PubMed
  134. Löw K, Crestani F, Keist R, Benke D, Brünig I, Benson JA, Fritschy JM, Rülicke T, Bluethmann H, Möhler H, Rudolph U. Molecular and neuronal substrate for the selective attenuation of anxiety. Science. 2000 Oct 06; 290(5489):131-4. PMID: 11021797.
    View in: PubMed
  135. Ohman L, Franzén L, Rudolph U, Harriman GR, Hultgren Hörnquist E. Immune activation in the intestinal mucosa before the onset of colitis in Galphai2-deficient mice. Scand J Immunol. 2000 Jul; 52(1):80-90. PMID: 10886787.
    View in: PubMed
  136. Rudolph U, Crestani F, Benke D, Brünig I, Benson JA, Fritschy JM, Martin JR, Bluethmann H, Möhler H. Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature. 1999 Oct 21; 401(6755):796-800. PMID: 10548105.
    View in: PubMed
  137. Rudolph U, Möhler H. Genetically modified animals in pharmacological research: future trends. Eur J Pharmacol. 1999 Jun 30; 375(1-3):327-37. PMID: 10443586.
    View in: PubMed
  138. Rudolph U, Mohler H. Transgenic and targeted mutant mice in drug discovery. Curr Opin Drug Discov Devel. 1999 Mar; 2(2):134-41. PMID: 19649939.
    View in: PubMed
  139. Benson JA, Löw K, Keist R, Mohler H, Rudolph U. Pharmacology of recombinant gamma-aminobutyric acidA receptors rendered diazepam-insensitive by point-mutated alpha-subunits. FEBS Lett. 1998 Jul 24; 431(3):400-4. PMID: 9714551.
    View in: PubMed
  140. Fritschy JM, Johnson DK, Mohler H, Rudolph U. Independent assembly and subcellular targeting of GABA(A)-receptor subtypes demonstrated in mouse hippocampal and olfactory neurons in vivo. Neurosci Lett. 1998 Jun 19; 249(2-3):99-102. PMID: 9682826.
    View in: PubMed
  141. Jiang M, Gold MS, Boulay G, Spicher K, Peyton M, Brabet P, Srinivasan Y, Rudolph U, Ellison G, Birnbaumer L. Multiple neurological abnormalities in mice deficient in the G protein Go. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):3269-74. PMID: 9501252; PMCID: PMC19731.
  142. Mohler H, Luscher B, Fritschy JM, Benke D, Benson J, Rudolph U. GABA(A)-receptor assembly in vivo: lessons from subunit mutant mice. Life Sci. 1998; 62(17-18):1611-5. PMID: 9585145.
    View in: PubMed
  143. Fritschy JM, Benke D, Johnson DK, Mohler H, Rudolph U. GABAA-receptor alpha-subunit is an essential prerequisite for receptor formation in vivo. Neuroscience. 1997 Dec; 81(4):1043-53. PMID: 9330366.
    View in: PubMed
  144. Hörnquist CE, Lu X, Rogers-Fani PM, Rudolph U, Shappell S, Birnbaumer L, Harriman GR. G(alpha)i2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines. J Immunol. 1997 Feb 01; 158(3):1068-77. PMID: 9013944.
    View in: PubMed
  145. Jiang M, Boulay G, Spicher K, Peyton MJ, Brabet P, Birnbaumer L, Rudolph U. Inactivation of the G alpha i2 and G alpha o genes by homologous recombination. Receptors Channels. 1997; 5(3-4):187-92. PMID: 9606722.
    View in: PubMed
  146. Rudolph U, Spicher K, Birnbaumer L. Adenylyl cyclase inhibition and altered G protein subunit expression and ADP-ribosylation patterns in tissues and cells from Gi2 alpha-/-mice. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3209-14. PMID: 8622915; PMCID: PMC39584.
  147. Mohler H, Fritschy JM, Lüscher B, Rudolph U, Benson J, Benke D. The GABAA receptors. From subunits to diverse functions. Ion Channels. 1996; 4:89-113. PMID: 8744207.
    View in: PubMed
  148. Rudolph U, Finegold MJ, Rich SS, Harriman GR, Srinivasan Y, Brabet P, Bradley A, Birnbaumer L. Gi2 alpha protein deficiency: a model of inflammatory bowel disease. J Clin Immunol. 1995 Nov; 15(6 Suppl):101S-105S. PMID: 8613481.
    View in: PubMed
  149. Rudolph U, Finegold MJ, Rich SS, Harriman GR, Srinivasan Y, Brabet P, Boulay G, Bradley A, Birnbaumer L. Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat Genet. 1995 Jun; 10(2):143-50. PMID: 7663509.
    View in: PubMed
  150. Rudolph U, Bradley A, Birnbaumer L. Targeted inactivation of the Gi2 alpha gene with replacement and insertion vectors: analysis in a 96-well plate format. Methods Enzymol. 1994; 237:366-86. PMID: 7935011.
    View in: PubMed
  151. Rudolph U, Brabet P, Hasty P, Bradley A, Birnbaumer L. Disruption of the G(i2) alpha locus in embryonic stem cells and mice: a modified hit and run strategy with detection by a PCR dependent on gap repair. Transgenic Res. 1993 Nov; 2(6):345-55. PMID: 8268981.
    View in: PubMed
  152. Rudolph U, Brabet P, Kaplan J, Hasty P, Bradley A, Birnbaumer L. Targeting of the Gi2 alpha gene in ES cells with replacement and insertion vectors. J Recept Res. 1993; 13(1-4):619-37. PMID: 8450507.
    View in: PubMed
  153. Spicher K, Klinz FJ, Rudolph U, Codina J, Birnbaumer L, Schultz G, Rosenthal W. Identification of the G-protein alpha-subunit encoded by alpha o2 cDNA as a 39 kDa pertussis toxin substrate. Biochem Biophys Res Commun. 1991 Mar 15; 175(2):473-9. PMID: 1902093.
    View in: PubMed
  154. Bertrand P, Sanford J, Rudolph U, Codina J, Birnbaumer L. At least three alternatively spliced mRNAs encoding two alpha subunits of the Go GTP-binding protein can be expressed in a single tissue. J Biol Chem. 1990 Oct 25; 265(30):18576-80. PMID: 2120235.
    View in: PubMed
  155. Hsu WH, Rudolph U, Sanford J, Bertrand P, Olate J, Nelson C, Moss LG, Boyd AE, Codina J, Birnbaumer L. Molecular cloning of a novel splice variant of the alpha subunit of the mammalian Go protein. J Biol Chem. 1990 Jul 05; 265(19):11220-6. PMID: 2113531.
    View in: PubMed
  156. Rudolph U, Koesling D, Hinsch KD, Seifert R, Bigalke M, Schultz G, Rosenthal W. G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils. Mol Cell Endocrinol. 1989 May; 63(1-2):143-53. PMID: 2502457.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Rudolph's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
_
Co-Authors Expand Description
_
Similar People Expand Description
_
Same Department Expand Description
Physical Neighbors Expand Description
_