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Moritz F. Kircher, Ph.D., M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA222836 (KIRCHER, MORITZ FLORIAN) Feb 1, 2018 - Jan 31, 2023
    NIH/NCI
    Ultrabright Theranostic SERRS Nanoparticles for Gastrointestinal Endoscopy
    Role: Principal Investigator
  2. R01EB017748 (KIRCHER, MORITZ FLORIAN) Aug 1, 2014 - Jul 31, 2018
    NIH/NIBIB
    MRI-Photoacoustic-Raman Nanostars for Pre- and Intraoperative Multimodal Imaging
    Role: Principal Investigator
  3. S10OD016422 (KIRCHER, MORITZ FLORIAN) Jun 1, 2014 - May 31, 2015
    NIH
    GE Diamond DNP Polarizer
    Role: Principal Investigator
  4. K08CA163961 (KIRCHER, MORITZ FLORIAN) Aug 6, 2012 - Jul 31, 2017
    NIH/NCI
    Combined Pre & Intraoperative Brain Tumor Imaging Strategy using a Dual-Modality
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Pal S, Ray A, Andreou C, Zhou Y, Rakshit T, Wlodarczyk M, Maeda M, Toledo-Crow R, Berisha N, Yang J, Hsu HT, Oseledchyk A, Mondal J, Zou S, Kircher MF. DNA-enabled rational design of fluorescence-Raman bimodal nanoprobes for cancer imaging and therapy. Nat Commun. 2019 04 26; 10(1):1926. PMID: 31028250.
    Citations:    
  2. Andreou C, Oseledchyk A, Nicolson F, Berisha N, Pal S, Kircher MF. Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting. J Vis Exp. 2019 Mar 25; (145). PMID: 30958459.
    Citations:    
  3. Harmsen S, Rogalla S, Huang R, Spaliviero M, Neuschmelting V, Hayakawa Y, Lee Y, Tailor Y, Toledo-Crow R, Kang JW, Samii JM, Karabeber H, Davis RM, White JR, van de Rijn M, Gambhir SS, Contag CH, Wang TC, Kircher MF. Detection of Premalignant Gastrointestinal Lesions Using Surface-Enhanced Resonance Raman Scattering-Nanoparticle Endoscopy. ACS Nano. 2019 Feb 26; 13(2):1354-1364. PMID: 30624916.
    Citations:    
  4. Kircher MF. Passing the Baton - From the Editor-in-Chief. Nanotheranostics. 2018; 2(3):269-270. PMID: 29911001.
    Citations:    
  5. Roberts S, Andreou C, Choi C, Donabedian P, Jayaraman M, Pratt EC, Tang J, Pérez-Medina C, Jason de la Cruz M, Mulder WJM, Grimm J, Kircher M, Reiner T. Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer. Chem Sci. 2018 Jul 07; 9(25):5646-5657. PMID: 30061998.
    Citations:    
  6. Neuschmelting V, Harmsen S, Beziere N, Lockau H, Hsu HT, Huang R, Razansky D, Ntziachristos V, Kircher MF. Dual-Modality Surface-Enhanced Resonance Raman Scattering and Multispectral Optoacoustic Tomography Nanoparticle Approach for Brain Tumor Delineation. Small. 2018 Jun; 14(23):e1800740. PMID: 29726109.
    Citations:    
  7. Kotrotsou A, Elakkad A, Sun J, Thomas GA, Yang D, Abrol S, Wei W, Weinberg JS, Bakhtiari AS, Kircher MF, Luedi MM, de Groot JF, Sawaya R, Kumar AJ, Zinn PO, Colen RR. Multi-center study finds postoperative residual non-enhancing component of glioblastoma as a new determinant of patient outcome. J Neurooncol. 2018 Aug; 139(1):125-133. PMID: 29619649.
    Citations:    
  8. Neuschmelting V, Kim K, Malekzadeh-Najafabadi J, Jebiwott S, Prakash J, Scherz A, Coleman JA, Kircher MF, Ntziachristos V. WST11 Vascular Targeted Photodynamic Therapy Effect Monitoring by Multispectral Optoacoustic Tomography (MSOT) in Mice. Theranostics. 2018; 8(3):723-734. PMID: 29344301.
    Citations:    
  9. Brand C, Iacono P, Pérez-Medina C, Mulder WJM, Kircher MF, Reiner T. Specific Binding of Liposomal Nanoparticles through Inverse Electron-Demand Diels-Alder Click Chemistry. ChemistryOpen. 2017 10; 6(5):615-619. PMID: 29046855.
    Citations:    
  10. Wall MA, Shaffer TM, Harmsen S, Tschaharganeh DF, Huang CH, Lowe SW, Drain CM, Kircher MF. Chelator-Free Radiolabeling of SERRS Nanoparticles for Whole-Body PET and Intraoperative Raman Imaging. Theranostics. 2017; 7(12):3068-3077. PMID: 28839464.
    Citations:    
  11. Pal S, Harmsen S, Oseledchyk A, Hsu HT, Kircher MF. MUC1 Aptamer Targeted SERS Nanoprobes. Adv Funct Mater. 2017 Aug 25; 27(32). PMID: 29147108.
    Citations:    
  12. Harmsen S, Wall MA, Huang R, Kircher MF. Cancer imaging using surface-enhanced resonance Raman scattering nanoparticles. Nat Protoc. 2017 Jul; 12(7):1400-1414. PMID: 28686581.
    Citations:    
  13. Andreou C, Pal S, Rotter L, Yang J, Kircher MF. Molecular Imaging in Nanotechnology and Theranostics. Mol Imaging Biol. 2017 06; 19(3):363-372. PMID: 28349293.
    Citations:    
  14. Wall MA, Harmsen S, Pal S, Zhang L, Arianna G, Lombardi JR, Drain CM, Kircher MF. Surfactant-Free Shape Control of Gold Nanoparticles Enabled by Unified Theoretical Framework of Nanocrystal Synthesis. Adv Mater. 2017 Jun; 29(21). PMID: 28374940.
    Citations:    
  15. Nayak TR, Andreou C, Oseledchyk A, Marcus WD, Wong HC, Massagué J, Kircher MF. Tissue factor-specific ultra-bright SERRS nanostars for Raman detection of pulmonary micrometastases. Nanoscale. 2017 Jan 19; 9(3):1110-1119. PMID: 27991632.
    Citations:    
  16. Kircher MF. How can we apply the use of surface-enhanced Raman scattering nanoparticles in tumor imaging? Nanomedicine (Lond). 2017 02; 12(3):171-174. PMID: 28078943.
    Citations:    
  17. Oseledchyk A, Andreou C, Wall MA, Kircher MF. Folate-Targeted Surface-Enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detection of Microscopic Ovarian Cancer. ACS Nano. 2017 02 28; 11(2):1488-1497. PMID: 27992724.
    Citations:    
  18. Kircher MF, Hricak H, Larson SM. Corrigendum to "Molecular imaging for personalized cancer care" [Mol. Oncol. 6(2) (2012) 182-195]. Mol Oncol. 2016 12; 10(10):1627. PMID: 27727085.
    Citations:    
  19. Spaliviero M, Harmsen S, Huang R, Wall MA, Andreou C, Eastham JA, Touijer KA, Scardino PT, Kircher MF. Detection of Lymph Node Metastases with SERRS Nanoparticles. Mol Imaging Biol. 2016 10; 18(5):677-85. PMID: 26943129.
    Citations:    
  20. Shaffer TM, Harmsen S, Khwaja E, Kircher MF, Drain CM, Grimm J. Stable Radiolabeling of Sulfur-Functionalized Silica Nanoparticles with Copper-64. Nano Lett. 2016 09 14; 16(9):5601-4. PMID: 27464258.
    Citations:    
  21. Agostini A, Kircher MF, Do RK, Borgheresi A, Monti S, Giovagnoni A, Mannelli L. Magnetic Resonanance Imaging of the Liver (Including Biliary Contrast Agents)-Part 2: Protocols for Liver Magnetic Resonanance Imaging and Characterization of Common Focal Liver Lesions. Semin Roentgenol. 2016 Oct; 51(4):317-333. PMID: 27743568.
    Citations:    
  22. Andreou C, Neuschmelting V, Tschaharganeh DF, Huang CH, Oseledchyk A, Iacono P, Karabeber H, Colen RR, Mannelli L, Lowe SW, Kircher MF. Imaging of Liver Tumors Using Surface-Enhanced Raman Scattering Nanoparticles. ACS Nano. 2016 05 24; 10(5):5015-26. PMID: 27078225.
    Citations:    
  23. Huang R, Harmsen S, Samii JM, Karabeber H, Pitter KL, Holland EC, Kircher MF. High Precision Imaging of Microscopic Spread of Glioblastoma with a Targeted Ultrasensitive SERRS Molecular Imaging Probe. Theranostics. 2016; 6(8):1075-84. PMID: 27279902.
    Citations:    
  24. Neuschmelting V, Lockau H, Ntziachristos V, Grimm J, Kircher MF. Lymph Node Micrometastases and In-Transit Metastases from Melanoma: In Vivo Detection with Multispectral Optoacoustic Imaging in a Mouse Model. Radiology. 2016 07; 280(1):137-50. PMID: 27144537.
    Citations:    
  25. Neuschmelting V, Burton NC, Lockau H, Urich A, Harmsen S, Ntziachristos V, Kircher MF. Performance of a Multispectral Optoacoustic Tomography (MSOT) System equipped with 2D vs. 3D Handheld Probes for Potential Clinical Translation. Photoacoustics. 2016 Mar; 4(1):1-10. PMID: 27069872.
    Citations:    
  26. Andreou C, Kishore SA, Kircher MF. Surface-Enhanced Raman Spectroscopy: A New Modality for Cancer Imaging. J Nucl Med. 2015 Sep; 56(9):1295-9. PMID: 26182971.
    Citations:    
  27. Harmsen S, Bedics MA, Wall MA, Huang R, Detty MR, Kircher MF. Rational design of a chalcogenopyrylium-based surface-enhanced resonance Raman scattering nanoprobe with attomolar sensitivity. Nat Commun. 2015 Mar 24; 6:6570. PMID: 25800697.
    Citations:    
  28. Harmsen S, Huang R, Wall MA, Karabeber H, Samii JM, Spaliviero M, White JR, Monette S, O'Connor R, Pitter KL, Sastra SA, Saborowski M, Holland EC, Singer S, Olive KP, Lowe SW, Blasberg RG, Kircher MF. Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging. Sci Transl Med. 2015 Jan 21; 7(271):271ra7. PMID: 25609167.
    Citations:    
  29. Shaffer TM, Wall MA, Harmsen S, Longo VA, Drain CM, Kircher MF, Grimm J. Silica nanoparticles as substrates for chelator-free labeling of oxophilic radioisotopes. Nano Lett. 2015 Feb 11; 15(2):864-8. PMID: 25559467.
    Citations:    
  30. Kempen PJ, Kircher MF, de la Zerda A, Zavaleta CL, Jokerst JV, Mellinghoff IK, Gambhir SS, Sinclair R. A correlative optical microscopy and scanning electron microscopy approach to locating nanoparticles in brain tumors. Micron. 2015 Jan; 68:70-76. PMID: 25464144.
    Citations:    
  31. Iacono P, Karabeber H, Kircher MF. A "schizophotonic" all-in-one nanoparticle coating for multiplexed SE(R)RS biomedical imaging. Angew Chem Int Ed Engl. 2014 Oct 27; 53(44):11756-61. PMID: 25164141.
    Citations:    
  32. Karabeber H, Huang R, Iacono P, Samii JM, Pitter K, Holland EC, Kircher MF. Guiding brain tumor resection using surface-enhanced Raman scattering nanoparticles and a hand-held Raman scanner. ACS Nano. 2014 Oct 28; 8(10):9755-66. PMID: 25093240.
    Citations:    
  33. Zhang E, Kircher MF, Koch M, Eliasson L, Goldberg SN, Renström E. Dynamic magnetic fields remote-control apoptosis via nanoparticle rotation. ACS Nano. 2014 Apr 22; 8(4):3192-201. PMID: 24597847.
    Citations:    
  34. Huang R, Vider J, Kovar JL, Olive DM, Mellinghoff IK, Mayer-Kuckuk P, Kircher MF, Blasberg RG. Integrin avß3-targeted IRDye 800CW near-infrared imaging of glioblastoma. Clin Cancer Res. 2012 Oct 15; 18(20):5731-40. PMID: 22914772.
    Citations:    
  35. Kircher MF, Willmann JK. Molecular body imaging: MR imaging, CT, and US. Part II. Applications. Radiology. 2012 Aug; 264(2):349-68. PMID: 22821695.
    Citations:    
  36. Kircher MF, Willmann JK. Molecular body imaging: MR imaging, CT, and US. part I. principles. Radiology. 2012 Jun; 263(3):633-43. PMID: 22623690.
    Citations:    
  37. Kircher MF, de la Zerda A, Jokerst JV, Zavaleta CL, Kempen PJ, Mittra E, Pitter K, Huang R, Campos C, Habte F, Sinclair R, Brennan CW, Mellinghoff IK, Holland EC, Gambhir SS. A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle. Nat Med. 2012 Apr 15; 18(5):829-34. PMID: 22504484.
    Citations: 160     Fields:    Translation:HumansAnimals
  38. Kircher MF, Hricak H, Larson SM. Molecular imaging for personalized cancer care. Mol Oncol. 2012 Apr; 6(2):182-95. PMID: 22469618.
    Citations:    
  39. Kircher MF, Gambhir SS, Grimm J. Noninvasive cell-tracking methods. Nat Rev Clin Oncol. 2011 Sep 27; 8(11):677-88. PMID: 21946842.
    Citations:    
  40. Zavaleta CL, Kircher MF, Gambhir SS. Raman's "effect" on molecular imaging. J Nucl Med. 2011 Dec; 52(12):1839-44. PMID: 21868625.
    Citations:    
  41. Kircher MF, Hines-Peralta A, Boiselle PM, Donohoe K, Siewert B. Implementation of screen-capture video recordings of resident conferences in an academic radiology department: pilot experience. Acad Radiol. 2010 Feb; 17(2):255-63. PMID: 19914847.
    Citations: 1     Fields:    
  42. Kircher MF, Grimm J, Swirski FK, Libby P, Gerszten RE, Allport JR, Weissleder R. Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions. Circulation. 2008 Jan 22; 117(3):388-95. PMID: 18172031.
    Citations: 31     Fields:    Translation:AnimalsCells
  43. Kircher MF, Milla S, Callahan MJ. Ingestion of magnetic foreign bodies causing multiple bowel perforations. Pediatr Radiol. 2007 Sep; 37(9):933-6. PMID: 17622522.
    Citations: 8     Fields:    Translation:Humans
  44. Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R. Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10340-10345. PMID: 16801531.
    Citations: 116     Fields:    Translation:AnimalsCells
  45. Vianello F, Papeta N, Chen T, Kraft P, White N, Hart WK, Kircher MF, Swart E, Rhee S, Palù G, Irimia D, Toner M, Weissleder R, Poznansky MC. Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control. J Immunol. 2006 Mar 01; 176(5):2902-14. PMID: 16493048.
    Citations: 29     Fields:    Translation:AnimalsCells
  46. Pham W, Kircher MF, Weissleder R, Tung CH. Enhancing membrane permeability by fatty acylation of oligoarginine peptides. Chembiochem. 2004 Aug 06; 5(8):1148-51. PMID: 15300843.
    Citations: 17     Fields:    Translation:HumansCells
  47. Kircher MF, Weissleder R, Josephson L. A dual fluorochrome probe for imaging proteases. Bioconjug Chem. 2004 Mar-Apr; 15(2):242-8. PMID: 15025519.
    Citations: 23     Fields:    Translation:AnimalsCells
  48. Kircher MF, Mahmood U, King RS, Weissleder R, Josephson L. A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation. Cancer Res. 2003 Dec 01; 63(23):8122-5. PMID: 14678964.
    Citations: 101     Fields:    Translation:AnimalsCells
  49. Kircher MF, Allport JR, Graves EE, Love V, Josephson L, Lichtman AH, Weissleder R. In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors. Cancer Res. 2003 Oct 15; 63(20):6838-46. PMID: 14583481.
    Citations: 89     Fields:    Translation:AnimalsCells
  50. Zhao M, Kircher MF, Josephson L, Weissleder R. Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjug Chem. 2002 Jul-Aug; 13(4):840-4. PMID: 12121140.
    Citations: 48     Fields:    Translation:AnimalsCells
  51. Kircher MF, Rhea JT, Kihiczak D, Novelline RA. Frequency, sensitivity, and specificity of individual signs of diverticulitis on thin-section helical CT with colonic contrast material: experience with 312 cases. AJR Am J Roentgenol. 2002 Jun; 178(6):1313-8. PMID: 12034590.
    Citations: 26     Fields:    Translation:Humans
  52. Josephson L, Kircher MF, Mahmood U, Tang Y, Weissleder R. Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem. 2002 May-Jun; 13(3):554-60. PMID: 12009946.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  53. Kircher MF, Josephson L, Weissleder R. Ratio imaging of enzyme activity using dual wavelength optical reporters. Mol Imaging. 2002 Apr-Jun; 1(2):89-95. PMID: 12920849.
    Citations: 7     Fields:    Translation:AnimalsCells
  54. Kircher MF, Haeusler T, Nickel R, Lamb JR, Renz H, Beyer K. Vbeta18.1(+) and V(alpha)2.3(+) T-cell subsets are associated with house dust mite allergy in human subjects. J Allergy Clin Immunol. 2002 Mar; 109(3):517-23. PMID: 11898001.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.