Harvard Catalyst Profiles

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Calum Archibald MacRae, Ph.D., M.D.

Title
Institution
Department
Address
Phone
Fax

Mentoring
Integration of in Vitro and in Vivo Models of Arrhythmogenic Cardiomyopathy to Define Pathogenic Mechanisms and Identify Small Molecule Therapies
Summer, 06/01/18 - 08/31/18
Development of a new zebrafish model for studying cell-autonomous connexin mutants linked to atrial fibrillation
Summer, 06/05/15 - 08/15/15

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U54NS112107 (MACRAE, CALUM A.) Aug 1, 2019 - May 31, 2024
    NIH
    Advancing novel cyanide countermeasures
    Role: Principal Investigator
  2. R01HG009174 (MURPHY, SHAWN N) Sep 28, 2016 - Feb 28, 2021
    NIH
    Developing i2b2 into a Health Innovation Platform for Clinical Decision Support in the Genomics Era
    Role: Co-Principal Investigator
  3. R24OD017870 (GOESSLING, WOLFRAM) May 1, 2014 - Jul 31, 2022
    NIH
    A Community Zebrafish Resource for Modeling GWAS Biology
    Role: Co-Principal Investigator
  4. U54NS079201 (MACRAE, CALUM A.) Sep 30, 2012 - Aug 31, 2018
    NIH
    A Discovery and Development Pipeline for Cyanide Countermeasures
    Role: Principal Investigator
  5. R01HL109264 (MACRAE, CALUM A.) Apr 9, 2012 - Feb 29, 2016
    NIH
    Development of a High-throughput Integrated In Vivo Heart Failure Assay
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Akerberg AA, Trembley M, Butty V, Schwertner A, Zhao L, Beerens M, Liu X, Mahamdeh M, Yuan S, Boyer L, MacRae C, Nguyen C, Pu WT, Burns CE, Burns CG. RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function. Circ Res. 2022 Nov 11. PMID: 36367103.
    Citations:    Fields:    
  2. Bebarta VS, Shi X, Zheng S, Hendry-Hofer TB, Severance CC, Behymer MM, Boss GR, Mahon S, Brenner M, Knipp GT, Davisson VJ, Peterson RT, MacRae CA, Rutter J, Gerszten RE, Nath AK. Intramuscular Administration of Glyoxylate Rescues Swine from Lethal Cyanide Poisoning and Ameliorates the Biochemical Sequalae of Cyanide Intoxication. Toxicol Sci. 2022 Nov 03. PMID: 36326479.
    Citations:    Fields:    
  3. Behymer MM, Mo H, Fujii N, Suresh V, Chan A, Lee J, Nath AK, Saha K, Mahon SB, Brenner M, MacRae CA, Peterson R, Boss GR, Knipp GT, Davisson VJ. Identification of Platinum(II) Sulfide Complexes Suitable as Intramuscular Cyanide Countermeasures. Chem Res Toxicol. 2022 Nov 21; 35(11):1983-1996. PMID: 36201358; PMCID: PMC9682522.
    Citations:    Fields:    
  4. MacRae CA, Peterson RT. Zebrafish as a Mainstream Model for In Vivo Systems Pharmacology and Toxicology. Annu Rev Pharmacol Toxicol. 2022 Sep 23. PMID: 36151053.
    Citations:    Fields:    
  5. Judge DP, Lakdawala NK, Taylor MRG, Mestroni L, Li H, Oliver C, Angeli FS, Lee PA, MacRae CA. Long-Term Efficacy and Safety of ARRY-371797 (PF-07265803) in Patients With Lamin A/C-Related Dilated Cardiomyopathy. Am J Cardiol. 2022 11 15; 183:93-98. PMID: 36114020.
    Citations:    Fields:    Translation:Humans
  6. Cheng KC, Burdine RD, Dickinson ME, Ekker SC, Lin AY, Lloyd KCK, Lutz CM, MacRae CA, Morrison JH, O'Connor DH, Postlethwait JH, Rogers CD, Sanchez S, Simpson JH, Talbot WS, Wallace DC, Weimer JM, Bellen HJ. Promoting validation and cross-phylogenetic integration in model organism research. Dis Model Mech. 2022 09 01; 15(9). PMID: 36125045; PMCID: PMC9531892.
    Citations: 1     Fields:    Translation:HumansAnimals
  7. Goto S, Solanki D, John JE, Yagi R, Homilius M, Ichihara G, Katsumata Y, Gaggin HK, Itabashi Y, MacRae CA, Deo RC. Multinational Federated Learning Approach to Train ECG and Echocardiogram Models for Hypertrophic Cardiomyopathy Detection. Circulation. 2022 Sep 06; 146(10):755-769. PMID: 35916132; PMCID: PMC9439630.
    Citations: 1     Fields:    Translation:Humans
  8. De Jong HN, Dewey FE, Cordero P, Victorio RA, Kirillova A, Huang Y, Madhvani R, Seo K, Werdich AA, Lan F, Orcholski M, Liu WR, Erbilgin A, Wheeler MT, Chen R, Pan S, Kim YM, Bommakanti K, Marcou CA, Bos JM, Haddad F, Ackerman M, Vasan RS, MacRae C, Wu JC, de Jesus Perez V, Snyder M, Parikh VN, Ashley EA. Wnt Signaling Interactor WTIP (Wilms Tumor Interacting Protein) Underlies Novel Mechanism for Cardiac Hypertrophy. Circ Genom Precis Med. 2022 08; 15(4):e003563. PMID: 35671065.
    Citations:    Fields:    
  9. Zhu W, Deo RC, MacRae CA. Single Cell Biology: Exploring Somatic Cell Behaviors, Competition and Selection in Chronic Disease. Front Pharmacol. 2022; 13:867431. PMID: 35656307; PMCID: PMC9152313.
    Citations:    
  10. Barc J, Tadros R, Glinge C, Chiang DY, Jouni M, Simonet F, Jurgens SJ, Baudic M, Nicastro M, Potet F, Offerhaus JA, Walsh R, Choi SH, Verkerk AO, Mizusawa Y, Anys S, Minois D, Arnaud M, Duchateau J, Wijeyeratne YD, Muir A, Papadakis M, Castelletti S, Torchio M, Ortuño CG, Lacunza J, Giachino DF, Cerrato N, Martins RP, Campuzano O, Van Dooren S, Thollet A, Kyndt F, Mazzanti A, Clémenty N, Bisson A, Corveleyn A, Stallmeyer B, Dittmann S, Saenen J, Noël A, Honarbakhsh S, Rudic B, Marzak H, Rowe MK, Federspiel C, Le Page S, Placide L, Milhem A, Barajas-Martinez H, Beckmann BM, Krapels IP, Steinfurt J, Winkel BG, Jabbari R, Shoemaker MB, Boukens BJ, Škoric-Milosavljevic D, Bikker H, Manevy F, Lichtner P, Ribasés M, Meitinger T, Müller-Nurasyid M, Veldink JH, van den Berg LH, Van Damme P, Cusi D, Lanzani C, Rigade S, Charpentier E, Baron E, Bonnaud S, Lecointe S, Donnart A, Le Marec H, Chatel S, Karakachoff M, Bézieau S, London B, Tfelt-Hansen J, Roden D, Odening KE, Cerrone M, Chinitz LA, Volders PG, van de Berg MP, Laurent G, Faivre L, Antzelevitch C, Kääb S, Arnaout AA, Dupuis JM, Pasquie JL, Billon O, Roberts JD, Jesel L, Borggrefe M, Lambiase PD, Mansourati J, Loeys B, Leenhardt A, Guicheney P, Maury P, Schulze-Bahr E, Robyns T, Breckpot J, Babuty D, Priori SG, Napolitano C, de Asmundis C, Brugada P, Brugada R, Arbelo E, Brugada J, Mabo P, Behar N, Giustetto C, Molina MS, Gimeno JR, Hasdemir C, Schwartz PJ, Crotti L, McKeown PP, Sharma S, Behr ER, Haissaguerre M, Sacher F, Rooryck C, Tan HL, Remme CA, Postema PG, Delmar M, Ellinor PT, Lubitz SA, Gourraud JB, Tanck MW, George AL, MacRae CA, Burridge PW, Dina C, Probst V, Wilde AA, Schott JJ, Redon R, Bezzina CR. Author Correction: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility. Nat Genet. 2022 May; 54(5):735. PMID: 35474365.
    Citations:    Fields:    
  11. Truslow JG, Goto S, Homilius M, Mow C, Higgins JM, MacRae CA, Deo RC. Cardiovascular Risk Assessment Using Artificial Intelligence-Enabled Event Adjudication and Hematologic Predictors. Circ Cardiovasc Qual Outcomes. 2022 06; 15(6):e008007. PMID: 35477255; PMCID: PMC9208816.
    Citations:    Fields:    Translation:Humans
  12. Perl E, Ravisankar P, Beerens ME, Mulahasanovic L, Smallwood K, Sasso MB, Wenzel C, Ryan TD, Komár M, Bove KE, MacRae CA, Weaver KN, Prada CE, Waxman JS. Stx4 is required to regulate cardiomyocyte Ca2+ handling during vertebrate cardiac development. HGG Adv. 2022 Jul 14; 3(3):100115. PMID: 35599850; PMCID: PMC9114686.
    Citations:    
  13. Nielson JR, Nath AK, Doane KP, Shi X, Lee J, Tippetts EG, Saha K, Morningstar J, Hicks KG, Chan A, Zhao Y, Kelly A, Hendry-Hofer TB, Witeof A, Sips PY, Mahon S, Bebarta VS, Davisson VJ, Boss GR, Rutter J, MacRae CA, Brenner M, Gerszten RE, Peterson RT. Glyoxylate protects against cyanide toxicity through metabolic modulation. Sci Rep. 2022 03 23; 12(1):4982. PMID: 35322094; PMCID: PMC8943054.
    Citations:    Fields:    Translation:Animals
  14. Kamerzell TJ, Mikell B, Chen L, Elias H, Dawn B, MacRae C, Middaugh CR. The structural basis of histone modifying enzyme specificity and promiscuity: Implications for metabolic regulation and drug design. Adv Protein Chem Struct Biol. 2022; 130:189-243. PMID: 35534108.
    Citations:    Fields:    Translation:Cells
  15. Barc J, Tadros R, Glinge C, Chiang DY, Jouni M, Simonet F, Jurgens SJ, Baudic M, Nicastro M, Potet F, Offerhaus JA, Walsh R, Choi SH, Verkerk AO, Mizusawa Y, Anys S, Minois D, Arnaud M, Duchateau J, Wijeyeratne YD, Muir A, Papadakis M, Castelletti S, Torchio M, Ortuño CG, Lacunza J, Giachino DF, Cerrato N, Martins RP, Campuzano O, Van Dooren S, Thollet A, Kyndt F, Mazzanti A, Clémenty N, Bisson A, Corveleyn A, Stallmeyer B, Dittmann S, Saenen J, Noël A, Honarbakhsh S, Rudic B, Marzak H, Rowe MK, Federspiel C, Le Page S, Placide L, Milhem A, Barajas-Martinez H, Beckmann BM, Krapels IP, Steinfurt J, Winkel BG, Jabbari R, Shoemaker MB, Boukens BJ, Škoric-Milosavljevic D, Bikker H, Manevy F, Lichtner P, Ribasés M, Meitinger T, Müller-Nurasyid M, Veldink JH, van den Berg LH, Van Damme P, Cusi D, Lanzani C, Rigade S, Charpentier E, Baron E, Bonnaud S, Lecointe S, Donnart A, Le Marec H, Chatel S, Karakachoff M, Bézieau S, London B, Tfelt-Hansen J, Roden D, Odening KE, Cerrone M, Chinitz LA, Volders PG, van de Berg MP, Laurent G, Faivre L, Antzelevitch C, Kääb S, Arnaout AA, Dupuis JM, Pasquie JL, Billon O, Roberts JD, Jesel L, Borggrefe M, Lambiase PD, Mansourati J, Loeys B, Leenhardt A, Guicheney P, Maury P, Schulze-Bahr E, Robyns T, Breckpot J, Babuty D, Priori SG, Napolitano C, de Asmundis C, Brugada P, Brugada R, Arbelo E, Brugada J, Mabo P, Behar N, Giustetto C, Molina MS, Gimeno JR, Hasdemir C, Schwartz PJ, Crotti L, McKeown PP, Sharma S, Behr ER, Haissaguerre M, Sacher F, Rooryck C, Tan HL, Remme CA, Postema PG, Delmar M, Ellinor PT, Lubitz SA, Gourraud JB, Tanck MW, George AL, MacRae CA, Burridge PW, Dina C, Probst V, Wilde AA, Schott JJ, Redon R, Bezzina CR. Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility. Nat Genet. 2022 03; 54(3):232-239. PMID: 35210625; PMCID: PMC9376964.
    Citations: 2     Fields:    Translation:Humans
  16. Aryan Z, Nascimben J, MacRae CA. Genetic Testing in Sudden Cardiac Arrest: the History and Physical Exam Remain Central in the Genomics Era. Circ Genom Precis Med. 2022 02; 15(1):e003520. PMID: 35103483.
    Citations:    Fields:    Translation:Humans
  17. Zhu W, Guo S, Homilius M, Nsubuga C, Wright SH, Quan D, Kc A, Eddy SS, Victorio RA, Beerens M, Flaumenhaft R, Deo RC, MacRae CA. PIEZO1 mediates a mechanothrombotic pathway in diabetes. Sci Transl Med. 2022 01 05; 14(626):eabk1707. PMID: 34985971.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  18. Yazdi D, Sridaran S, Smith S, Centen C, Patel S, Wilson E, Gillon L, Kapur S, Tracy JA, Lewine K, Systrom DM, MacRae CA. Noninvasive Scale Measurement of Stroke Volume and Cardiac Output Compared With the Direct Fick Method: A Feasibility Study. J Am Heart Assoc. 2021 12 21; 10(24):e021893. PMID: 34873927; PMCID: PMC9075258.
    Citations:    Fields:    Translation:Humans
  19. Ho CY, Day SM, Axelsson A, Russell MW, Zahka K, Lever HM, Pereira AC, Colan SD, Margossian R, Murphy AM, Canter C, Bach RG, Wheeler MT, Rossano JW, Owens AT, Bundgaard H, Benson L, Mestroni L, Taylor MRG, Patel AR, Wilmot I, Thrush P, Vargas JD, Soslow JH, Becker JR, Seidman CE, Lakdawala NK, Cirino AL, Burns KM, McMurray JJV, MacRae CA, Solomon SD, Orav EJ, Braunwald E. Valsartan in early-stage hypertrophic cardiomyopathy: a randomized phase 2 trial. Nat Med. 2021 10; 27(10):1818-1824. PMID: 34556856; PMCID: PMC8666141.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  20. Plutzky J, Benson MD, Chaney K, Bui TV, Kraft M, Matta L, McPartlin M, Zelle D, Cannon CP, Dodek A, Gaziano TA, Desai AS, MacRae CA, Scirica BM. Population health management of low-density lipoprotein cholesterol via a remote, algorithmic, navigator-executed program. Am Heart J. 2022 01; 243:15-27. PMID: 34481756.
    Citations:    Fields:    Translation:Humans