Harvard Catalyst Profiles

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Calum Archibald MacRae, Ph.D., M.D.

Title
Institution
Department
Address
Phone
Fax

Mentoring
Development of a new zebrafish model for studying cell-autonomous connexin mutants linked to atrial fibrillation
Summer, 06/05/15 - 08/15/15

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HG009174 (MURPHY, SHAWN N) Sep 28, 2016 - Aug 31, 2020
    NIH/NHGRI
    Developing i2b2 into a Health Innovation Platform for Clinical Decision Support in the Genomics Era
    Role: Co-Principal Investigator
  2. R24OD017870 (GOESSLING, WOLFRAM) May 1, 2014 - Jul 31, 2022
    NIH
    A Community Zebrafish Resource for Modeling GWAS Biology
    Role: Co-Principal Investigator
  3. U54NS079201 (MACRAE, CALUM A.) Sep 30, 2012 - Aug 31, 2017
    NIH/NINDS
    A Discovery and Development Pipeline for Cyanide Countermeasures
    Role: Principal Investigator
  4. R01HL109264 (MACRAE, CALUM A.) Apr 9, 2012 - Feb 28, 2015
    NIH/NHLBI
    Development of a High-throughput Integrated In Vivo Heart Failure Assay
    Role: Principal Investigator
  5. R21AG037925 (MACRAE, CALUM A.) Apr 1, 2012 - Mar 31, 2014
    NIH/NIA
    The Genetic Basis of the GAPO Progeroid Syndrome
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mishra S, Joshi S, Ward JE, Buys EP, Mishra D, Mishra D, Morgado I, Fisch S, Lavatelli F, Merlini G, Dorbala S, MacRae CA, Liao R. Zebrafish model of amyloid light chain cardiotoxicity: regeneration vs degeneration. Am J Physiol Heart Circ Physiol. 2019 Mar 15. PMID: 30875258.
    Citations:    
  2. Zhao Y, Zhang K, Sips P, MacRae CA. Screening drugs for myocardial disease in vivo with zebrafish: an expert update. Expert Opin Drug Discov. 2019 Apr; 14(4):343-353. PMID: 30836799.
    Citations:    
  3. Fisher NDL, Fera LE, Dunning JR, Desai S, Matta L, Liquori V, Pagliaro J, Pabo E, Merriam M, MacRae CA, Scirica BM. Development of an entirely remote, non-physician led hypertension management program. Clin Cardiol. 2019 Feb; 42(2):285-291. PMID: 30582181.
    Citations:    Fields:    
  4. Roder K, Kabakov A, Moshal KS, Murphy KR, Xie A, Dudley S, Turan NN, Lu Y, MacRae CA, Koren G. Trafficking of the human ether-a-go-go-related gene (hERG) potassium channel is regulated by the ubiquitin ligase rififylin (RFFL). J Biol Chem. 2019 Jan 04; 294(1):351-360. PMID: 30401747.
    Citations:    Fields:    
  5. Feghaly J, Zakka P, London B, MacRae CA, Refaat MM. Genetics of Atrial Fibrillation. J Am Heart Assoc. 2018 Oct 16; 7(20):e009884. PMID: 30371258.
    Citations:    Fields:    
  6. Seidelmann SB, Feofanova E, Yu B, Franceschini N, Claggett B, Kuokkanen M, Puolijoki H, Ebeling T, Perola M, Salomaa V, Shah A, Coresh J, Selvin E, MacRae CA, Cheng S, Boerwinkle E, Solomon SD. Genetic Variants in SGLT1, Glucose Tolerance, and Cardiometabolic Risk. J Am Coll Cardiol. 2018 Oct 09; 72(15):1763-1773. PMID: 30286918.
    Citations:    Fields:    
  7. Wagholikar KB, Fischer CM, Goodson A, Herrick CD, Rees M, Toscano E, MacRae CA, Scirica BM, Desai AS, Murphy SN. Extraction of Ejection Fraction from Echocardiography Notes for Constructing a Cohort of Patients having Heart Failure with reduced Ejection Fraction (HFrEF). J Med Syst. 2018 Sep 25; 42(11):209. PMID: 30255347.
    Citations:    Fields:    Translation:Humans
  8. Macrae CA. Rare Diseases Inform Myocardial Phenotypes for Precision Medicine. J Card Fail. 2018 10; 24(10):680-681. PMID: 30218700.
    Citations:    Fields:    Translation:Humans
  9. Haghighi A, Krier JB, Toth-Petroczy A, Cassa CA, Frank NY, Carmichael N, Fieg E, Bjonnes A, Mohanty A, Briere LC, Lincoln S, Lucia S, Gupta VA, Söylemez O, Sutti S, Kooshesh K, Qiu H, Fay CJ, Perroni V, Valerius J, Hanna M, Frank A, Ouahed J, Snapper SB, Pantazi A, Chopra SS, Leshchiner I, Stitziel NO, Feldweg A, Mannstadt M, Loscalzo J, Sweetser DA, Liao E, Stoler JM, Nowak CB, Sanchez-Lara PA, Klein OD, Perry H, Patsopoulos NA, Raychaudhuri S, Goessling W, Green RC, Seidman CE, MacRae CA, Sunyaev SR, Maas RL, Vuzman D. An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery. NPJ Genom Med. 2018; 3:21. PMID: 30131872.
    Citations:    
  10. Dempsey J, Gillis C, Sibicky S, Matta L, MacRae C, Kirshenbaum J, Faxon D, Churchill W. Evaluation of a transitional care pharmacist intervention in a high-risk cardiovascular patient population. Am J Health Syst Pharm. 2018 Sep 01; 75(17 Supplement 3):S63-S71. PMID: 29976830.
    Citations:    Fields:    
  11. Kithcart AP, MacRae CA. Zebrafish assay development for cardiovascular disease mechanism and drug discovery. Prog Biophys Mol Biol. 2018 10; 138:126-131. PMID: 30518489.
    Citations:    Fields:    
  12. Sips PY, Shi X, Musso G, Nath AK, Zhao Y, Nielson J, Morningstar J, Kelly AE, Mikell B, Buys E, Bebarta V, Rutter J, Davisson VJ, Mahon S, Brenner M, Boss GR, Peterson RT, Gerszten RE, MacRae CA. Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. PLoS One. 2018; 13(6):e0193889. PMID: 29879736.
    Citations:    Fields:    Translation:Animals
  13. Kapur S, Kumar S, John RM, Stevenson WG, Tedrow UB, Koplan BA, Epstein LM, MacRae CA, Michaud GF. Family history of atrial fibrillation as a predictor of atrial substrate and arrhythmia recurrence in patients undergoing atrial fibrillation catheter ablation. Europace. 2018 06 01; 20(6):921-928. PMID: 28541417.
    Citations:    Fields:    
  14. Musunuru K, Arora P, Cooke JP, Ferguson JF, Hershberger RE, Hickey KT, Lee JM, Lima JAC, Loscalzo J, Pereira NL, Russell MW, Shah SH, Sheikh F, Wang TJ, MacRae CA. Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine: A Scientific Statement From the American Heart Association. Circ Genom Precis Med. 2018 Jun; 11(6):e000046. PMID: 29844141.
    Citations:    
  15. Cranley J, MacRae CA. A New Approach to an Old Problem: One Brave Idea. Circ Res. 2018 Apr 27; 122(9):1172-1175. PMID: 29700065.
    Citations:    Fields:    
  16. Oldham WM, Oliveira RKF, Wang RS, Opotowsky AR, Rubins DM, Hainer J, Wertheim BM, Alba GA, Choudhary G, Tornyos A, MacRae CA, Loscalzo J, Leopold JA, Waxman AB, Olschewski H, Kovacs G, Systrom DM, Maron BA. Network Analysis to Risk Stratify Patients With Exercise Intolerance. Circ Res. 2018 Mar 16; 122(6):864-876. PMID: 29437835.
    Citations:    Fields:    
  17. Colombo S, de Sena-Tomás C, George V, Werdich AA, Kapur S, MacRae CA, Targoff KL. Nkx genes establish second heart field cardiomyocyte progenitors at the arterial pole and pattern the venous pole through Isl1 repression. Development. 2018 02 05; 145(3). PMID: 29361575.
    Citations:    Fields:    Translation:HumansAnimalsCells
  18. Natarajan N, Abbas Y, Bryant DM, Gonzalez-Rosa JM, Sharpe M, Uygur A, Cocco-Delgado LH, Ho NN, Gerard NP, Gerard CJ, MacRae CA, Burns CE, Burns CG, Whited JL, Lee RT. Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration. Circulation. 2018 May 15; 137(20):2152-2165. PMID: 29348261.
    Citations:    Fields:    
  19. Nikolova-Krstevski V, Wagner S, Yu ZY, Cox CD, Cvetkovska J, Hill AP, Huttner IG, Benson V, Werdich AA, MacRae C, Feneley MP, Friedrich O, Martinac B, Fatkin D. Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk. JACC Basic Transl Sci. 2017 Oct; 2(5):575-590. PMID: 30062171.
    Citations:    
  20. MacRae CA, Seidman CE. Closing the Genotype-Phenotype Loop for Precision Medicine. Circulation. 2017 10 17; 136(16):1492-1494. PMID: 29038206.
    Citations: 1     Fields:    
  21. Cirino AL, Lakdawala NK, McDonough B, Conner L, Adler D, Weinfeld M, O'Gara P, Rehm HL, Machini K, Lebo M, Blout C, Green RC, MacRae CA, Seidman CE, Ho CY. A Comparison of Whole Genome Sequencing to Multigene Panel Testing in Hypertrophic Cardiomyopathy Patients. Circ Cardiovasc Genet. 2017 Oct; 10(5). PMID: 29030401.
    Citations: 4     Fields:    Translation:HumansCells
  22. MacRae CA. Skin and Vascular Disease-Inside-Out/Outside-In. JAMA Cardiol. 2017 Sep 01; 2(9):944-945. PMID: 28564684.
    Citations:    Fields:    
  23. Aday AW, MacRae CA. Genomic Medicine in Cardiovascular Fellowship Training. Circulation. 2017 07 25; 136(4):345-346. PMID: 28739809.
    Citations: 2     Fields:    Translation:Humans
  24. Ito K, Patel PN, Gorham JM, McDonough B, DePalma SR, Adler EE, Lam L, MacRae CA, Mohiuddin SM, Fatkin D, Seidman CE, Seidman JG. Identification of pathogenic gene mutations in LMNA and MYBPC3 that alter RNA splicing. Proc Natl Acad Sci U S A. 2017 07 18; 114(29):7689-7694. PMID: 28679633.
    Citations: 2     Fields:    Translation:HumansCells
  25. Vassy JL, Christensen KD, Schonman EF, Blout CL, Robinson JO, Krier JB, Diamond PM, Lebo M, Machini K, Azzariti DR, Dukhovny D, Bates DW, MacRae CA, Murray MF, Rehm HL, McGuire AL, Green RC. The Impact of Whole-Genome Sequencing on the Primary Care and Outcomes of Healthy Adult Patients: A Pilot Randomized Trial. Ann Intern Med. 2017 08 01; 167(3):159-169. PMID: 28654958.
    Citations: 12     Fields:    
  26. Nath AK, Shi X, Harrison DL, Morningstar JE, Mahon S, Chan A, Sips P, Lee J, MacRae CA, Boss GR, Brenner M, Gerszten RE, Peterson RT. Cisplatin Analogs Confer Protection against Cyanide Poisoning. Cell Chem Biol. 2017 May 18; 24(5):565-575.e4. PMID: 28416275.
    Citations:    Fields:    Translation:HumansAnimalsCells
  27. Wild PS, Felix JF, Schillert A, Teumer A, Chen MH, Leening MJG, Völker U, Großmann V, Brody JA, Irvin MR, Shah SJ, Pramana S, Lieb W, Schmidt R, Stanton AV, Malzahn D, Smith AV, Sundström J, Minelli C, Ruggiero D, Lyytikäinen LP, Tiller D, Smith JG, Monnereau C, Di Tullio MR, Musani SK, Morrison AC, Pers TH, Morley M, Kleber ME, Aragam J, Benjamin EJ, Bis JC, Bisping E, Broeckel U, Cheng S, Deckers JW, Del Greco M F, Edelmann F, Fornage M, Franke L, Friedrich N, Harris TB, Hofer E, Hofman A, Huang J, Hughes AD, Kähönen M, Investigators K, Kruppa J, Lackner KJ, Lannfelt L, Laskowski R, Launer LJ, Leosdottir M, Lin H, Lindgren CM, Loley C, MacRae CA, Mascalzoni D, Mayet J, Medenwald D, Morris AP, Müller C, Müller-Nurasyid M, Nappo S, Nilsson PM, Nuding S, Nutile T, Peters A, Pfeufer A, Pietzner D, Pramstaller PP, Raitakari OT, Rice KM, Rivadeneira F, Rotter JI, Ruohonen ST, Sacco RL, Samdarshi TE, Schmidt H, Sharp ASP, Shields DC, Sorice R, Sotoodehnia N, Stricker BH, Surendran P, Thom S, Töglhofer AM, Uitterlinden AG, Wachter R, Völzke H, Ziegler A, Münzel T, März W, Cappola TP, Hirschhorn JN, Mitchell GF, Smith NL, Fox ER, Dueker ND, Jaddoe VWV, Melander O, Russ M, Lehtimäki T, Ciullo M, Hicks AA, Lind L, Gudnason V, Pieske B, Barron AJ, Zweiker R, Schunkert H, Ingelsson E, Liu K, Arnett DK, Psaty BM, Blankenberg S, Larson MG, Felix SB, Franco OH, Zeller T, Vasan RS, Dörr M. Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function. J Clin Invest. 2017 May 01; 127(5):1798-1812. PMID: 28394258.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  28. Seidelmann SB, Vardeny O, Claggett B, Yu B, Shah AM, Ballantyne CM, Selvin E, MacRae CA, Boerwinkle E, Solomon SD. An NPPB Promoter Polymorphism Associated With Elevated N-Terminal pro-B-Type Natriuretic Peptide and Lower Blood Pressure, Hypertension, and Mortality. J Am Heart Assoc. 2017 Mar 24; 6(4). PMID: 28341776.
    Citations: 2     Fields:    Translation:HumansCells
  29. Manolio TA, Fowler DM, Starita LM, Haendel MA, MacArthur DG, Biesecker LG, Worthey E, Chisholm RL, Green ED, Jacob HJ, McLeod HL, Roden D, Rodriguez LL, Williams MS, Cooper GM, Cox NJ, Herman GE, Kingsmore S, Lo C, Lutz C, MacRae CA, Nussbaum RL, Ordovas JM, Ramos EM, Robinson PN, Rubinstein WS, Seidman C, Stranger BE, Wang H, Westerfield M, Bult C. Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research. Cell. 2017 03 23; 169(1):6-12. PMID: 28340351.
    Citations: 14     Fields:    Translation:HumansAnimals
  30. Higgins EM, Bos JM, Mason-Suares H, Tester DJ, Ackerman JP, MacRae CA, Sol-Church K, Gripp KW, Urrutia R, Ackerman MJ. Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy. JCI Insight. 2017 Mar 09; 2(5):e91225. PMID: 28289718.
    Citations: 1     Fields:    
  31. Kithcart A, MacRae CA. Using Zebrafish for High-Throughput Screening of Novel Cardiovascular Drugs. JACC Basic Transl Sci. 2017 Feb; 2(1):1-12. PMID: 30167552.
    Citations: 3     
  32. Ho CY, McMurray JJV, Cirino AL, Colan SD, Day SM, Desai AS, Lipshultz SE, MacRae CA, Shi L, Solomon SD, Orav EJ, Braunwald E. The Design of the Valsartan for Attenuating Disease Evolution in Early Sarcomeric Hypertrophic Cardiomyopathy (VANISH) Trial. Am Heart J. 2017 May; 187:145-155. PMID: 28454798.
    Citations: 3     Fields:    Translation:HumansCellsCTClinical Trials
  33. Rider SA, Christian HC, Mullins LJ, Howarth AR, MacRae CA, Mullins JJ. Zebrafish mesonephric renin cells are functionally conserved and comprise two distinct morphological populations. Am J Physiol Renal Physiol. 2017 04 01; 312(4):F778-F790. PMID: 28179256.
    Citations: 4     Fields:    Translation:AnimalsCells
  34. Macrae CA. Discovering New Diseases to Accelerate Precision Medicine. Trans Am Clin Climatol Assoc. 2017; 128:83-89. PMID: 28790489.
    Citations:    Fields:    Translation:Humans
  35. Santiago-Sim T, Fang X, Hennessy ML, Nalbach SV, DePalma SR, Lee MS, Greenway SC, McDonough B, Hergenroeder GW, Patek KJ, Colosimo SM, Qualmann KJ, Hagan JP, Milewicz DM, MacRae CA, Dymecki SM, Seidman CE, Seidman JG, Kim DH. THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage. Stroke. 2016 12; 47(12):3005-3013. PMID: 27895300.
    Citations: 4     Fields:    Translation:HumansAnimals
  36. Rudin RS, Bates DW, MacRae C. Accelerating Innovation in Health IT. N Engl J Med. 2016 Sep 01; 375(9):815-7. PMID: 27579633.
    Citations: 6     Fields:    
  37. Lloyd KC, Robinson PN, MacRae CA. Animal-based studies will be essential for precision medicine. Sci Transl Med. 2016 08 17; 8(352):352ed12. PMID: 27535618.
    Citations: 1     Fields:    Translation:HumansAnimalsPHPublic Health
  38. MacRae CA, Boss G, Brenner M, Gerszten RE, Mahon S, Peterson RT. A countermeasure development pipeline. Ann N Y Acad Sci. 2016 08; 1378(1):58-67. PMID: 27737495.
    Citations:    Fields:    Translation:HumansAnimals
  39. Wang M, Sips P, Khin E, Rotival M, Sun X, Ahmed R, Widjaja AA, Schafer S, Yusoff P, Choksi PK, Ko NS, Singh MK, Epstein D, Guan Y, Houštek J, Mracek T, Nuskova H, Mikell B, Tan J, Pesce F, Kolar F, Bottolo L, Mancini M, Hubner N, Pravenec M, Petretto E, MacRae C, Cook SA. Wars2 is a determinant of angiogenesis. Nat Commun. 2016 07 08; 7:12061. PMID: 27389904.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  40. MacRae CA, Vasan RS. The Future of Genetics and Genomics: Closing the Phenotype Gap in Precision Medicine. Circulation. 2016 Jun 21; 133(25):2634-9. PMID: 27324359.
    Citations: 4     Fields:    Translation:HumansAnimals
  41. MacRae CA, Roden DM, Loscalzo J. The Future of Cardiovascular Therapeutics. Circulation. 2016 Jun 21; 133(25):2610-7. PMID: 27324356.
    Citations: 4     Fields:    Translation:HumansAnimals
  42. MacRae CA, Loscalzo J. The Future of Cardiovascular Biomedicine. Circulation. 2016 Jun 21; 133(25):2601-2. PMID: 27324354.
    Citations:    Fields:    Translation:HumansAnimals
  43. Brown DW, MacRae CA, Gardner TJ. The Future of Cardiovascular Education and Training. Circulation. 2016 Jun 21; 133(25):2734-42. PMID: 27324367.
    Citations:    Fields:    Translation:Humans
  44. Carreras ET, Chatzizisis YS, Mauri L, MacRae C. Acute Coronary Syndrome in a 52-Year-Old Woman With Scleroderma. Circulation. 2016 Jun 14; 133(24):2576-82. PMID: 27297349.
    Citations:    Fields:    Translation:Humans
  45. Chelko SP, Asimaki A, Andersen P, Bedja D, Amat-Alarcon N, DeMazumder D, Jasti R, MacRae CA, Leber R, Kleber AG, Saffitz JE, Judge DP. Central role for GSK3ß in the pathogenesis of arrhythmogenic cardiomyopathy. JCI Insight. 2016 Apr 21; 1(5). PMID: 27170944.
    Citations: 12     Fields:    
  46. Shah SH, Arnett D, Houser SR, Ginsburg GS, MacRae C, Mital S, Loscalzo J, Hall JL. Opportunities for the Cardiovascular Community in the Precision Medicine Initiative. Circulation. 2016 Jan 12; 133(2):226-31. PMID: 27028435.
    Citations: 6     Fields:    Translation:Humans
  47. Olabisi O, Al-Romaih K, Henderson J, Tomar R, Drummond I, MacRae C, Pollak M. From man to fish: What can Zebrafish tell us about ApoL1 nephropathy? Clin Nephrol. 2016 Supplement 1; 86 (2016)(13):114-118. PMID: 27509583.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  48. Morrison-Nozik A, Anand P, Zhu H, Duan Q, Sabeh M, Prosdocimo DA, Lemieux ME, Nordsborg N, Russell AP, MacRae CA, Gerber AN, Jain MK, Haldar SM. Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):E6780-9. PMID: 26598680; PMCID: PMC4679037.
    Citations: 10     Fields:    Translation:HumansAnimals
  49. Antman EM, Benjamin EJ, Harrington RA, Houser SR, Peterson ED, Bauman MA, Brown N, Bufalino V, Califf RM, Creager MA, Daugherty A, Demets DL, Dennis BP, Ebadollahi S, Jessup M, Lauer MS, Lo B, MacRae CA, McConnell MV, McCray AT, Mello MM, Mueller E, Newburger JW, Okun S, Packer M, Philippakis A, Ping P, Prasoon P, Roger VL, Singer S, Temple R, Turner MB, Vigilante K, Warner J, Wayte P. Acquisition, Analysis, and Sharing of Data in 2015 and Beyond: A Survey of the Landscape: A Conference Report From the American Heart Association Data Summit 2015. J Am Heart Assoc. 2015 Nov 05; 4(11). PMID: 26541391.
    Citations: 7     Fields:    Translation:Humans
  50. Cullere X, Plovie E, Bennett PM, MacRae CA, Mayadas TN. The cerebral cavernous malformation proteins CCM2L and CCM2 prevent the activation of the MAP kinase MEKK3. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):14284-9. PMID: 26540726; PMCID: PMC4655542.
    Citations: 10     Fields:    Translation:AnimalsCells
  51. MacRae CA, Pollak MR. Effect Size Does Matter: The Long Road to Mechanistic Insight From Genome-Wide Association. Circulation. 2015 Nov 24; 132(21):1943-5. PMID: 26487758.
    Citations: 1     Fields:    Translation:HumansCells
  52. Musso G, Mosimann C, Panáková D, Burger A, Zhou Y, Zon LI, MacRae CA. Generating and evaluating a ranked candidate gene list for potential vertebrate heart field regulators. Genom Data. 2015 Dec; 6:199-201. PMID: 26697374.
    Citations: 1     
  53. MacRae CA, Peterson RT. Zebrafish as tools for drug discovery. Nat Rev Drug Discov. 2015 Oct; 14(10):721-31. PMID: 26361349.
    Citations: 90     Fields:    Translation:HumansAnimals
  54. MacRae CA. In vitro and in vivo reprogramming for the conduction system. Trends Cardiovasc Med. 2016 Jan; 26(1):21-2. PMID: 26632016.
    Citations: 1     Fields:    Translation:Humans
  55. Treggiari D, Zoccatelli G, Molesini B, Degan M, Rotino GL, Sala T, Cavallini C, MacRae CA, Minuz P, Pandolfini T. A cystine-knot miniprotein from tomato fruit inhibits endothelial cell migration and angiogenesis by affecting vascular endothelial growth factor receptor (VEGFR) activation and nitric oxide production. Mol Nutr Food Res. 2015 Nov; 59(11):2255-66. PMID: 26255647.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  56. Mosimann C, Panáková D, Werdich AA, Musso G, Burger A, Lawson KL, Carr LA, Nevis KR, Sabeh MK, Zhou Y, Davidson AJ, DiBiase A, Burns CE, Burns CG, MacRae CA, Zon LI. Chamber identity programs drive early functional partitioning of the heart. Nat Commun. 2015 Aug 26; 6:8146. PMID: 26306682; PMCID: PMC4560818.
    Citations: 15     Fields:    Translation:AnimalsCells
  57. MacRae CA. A Critical Need for Clinical Context in the Genomic Era. Circulation. 2015 Sep 15; 132(11):992-3. PMID: 26276888.
    Citations:    Fields:    Translation:Humans
  58. Mahmoud AI, O'Meara CC, Gemberling M, Zhao L, Bryant DM, Zheng R, Gannon JB, Cai L, Choi WY, Egnaczyk GF, Burns CE, Burns CG, MacRae CA, Poss KD, Lee RT. Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration. Dev Cell. 2015 Aug 24; 34(4):387-99. PMID: 26256209; PMCID: PMC4550513.
    Citations: 35     Fields:    Translation:AnimalsCells
  59. Rider SA, Mullins LJ, Verdon RF, MacRae CA, Mullins JJ. Renin expression in developing zebrafish is associated with angiogenesis and requires the Notch pathway and endothelium. Am J Physiol Renal Physiol. 2015 Sep 15; 309(6):F531-9. PMID: 26202224; PMCID: PMC4572395.
    Citations: 7     Fields:    Translation:AnimalsCells
  60. Can A, Xu J, Volovici V, Dammers R, Dirven CM, MacRae CA, Du R. Fusiform Aneurysms Are Associated with Aortic Root Dilatation in Patients with Subarachnoid Hemorrhage. World Neurosurg. 2015 Dec; 84(6):1681-5. PMID: 26183134.
    Citations:    Fields:    Translation:Humans
  61. Burns AR, Luciani GM, Musso G, Bagg R, Yeo M, Zhang Y, Rajendran L, Glavin J, Hunter R, Redman E, Stasiuk S, Schertzberg M, Angus McQuibban G, Caffrey CR, Cutler SR, Tyers M, Giaever G, Nislow C, Fraser AG, MacRae CA, Gilleard J, Roy PJ. Caenorhabditis elegans is a useful model for anthelmintic discovery. Nat Commun. 2015 Jun 25; 6:7485. PMID: 26108372.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  62. Guan J, Mishra S, Qiu Y, Shi J, Trudeau K, Las G, Liesa M, Shirihai OS, Connors LH, Seldin DC, Falk RH, MacRae CA, Liao R. Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity. EMBO Mol Med. 2015 May; 7(5):688. PMID: 25940533; PMCID: PMC4492824.
    Citations: 2     Fields:    
  63. Korf B, Ahmadian R, Allanson J, Aoki Y, Bakker A, Wright EB, Denger B, Elgersma Y, Gelb BD, Gripp KW, Kerr B, Kontaridis M, Lazaro C, Linardic C, Lozano R, MacRae CA, Messiaen L, Mulero-Navarro S, Neel B, Plotkin S, Rauen KA, Roberts A, Silva AJ, Sittampalam SG, Zhang C, Schoyer L. The third international meeting on genetic disorders in the RAS/MAPK pathway: towards a therapeutic approach. Am J Med Genet A. 2015 Aug; 167A(8):1741-6. PMID: 25900621; PMCID: PMC4515140.
    Citations: 2     Fields:    Translation:HumansCells
  64. Fox CS, Hall JL, Arnett DK, Ashley EA, Delles C, Engler MB, Freeman MW, Johnson JA, Lanfear DE, Liggett SB, Lusis AJ, Loscalzo J, MacRae CA, Musunuru K, Newby LK, O'Donnell CJ, Rich SS, Terzic A. Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. Circulation. 2015 May 12; 131(19):1715-36. PMID: 25882488.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  65. Vassy JL, McLaughlin HM, McLaughlin HL, MacRae CA, Seidman CE, Lautenbach D, Krier JB, Lane WJ, Kohane IS, Murray MF, McGuire AL, Rehm HL, Green RC. A one-page summary report of genome sequencing for the healthy adult. Public Health Genomics. 2015; 18(2):123-9. PMID: 25612602; PMCID: PMC4348325.
    Citations: 11     Fields:    Translation:Humans
  66. MacRae CA. A new phenotypic lexicon for accelerated translation: rise of the machines. Circulation. 2015 Jan 20; 131(3):234-6. PMID: 25601949.
    Citations: 1     Fields:    Translation:HumansAnimals
  67. Tasan M, Musso G, Hao T, Vidal M, MacRae CA, Roth FP. Selecting causal genes from genome-wide association studies via functionally coherent subnetworks. Nat Methods. 2015 Feb; 12(2):154-9. PMID: 25532137; PMCID: PMC4480866.
    Citations: 19     Fields:    Translation:HumansAnimals
  68. McLaughlin HM, Ceyhan-Birsoy O, Christensen KD, Kohane IS, Krier J, Lane WJ, Lautenbach D, Lebo MS, Machini K, MacRae CA, Azzariti DR, Murray MF, Seidman CE, Vassy JL, Green RC, Rehm HL. A systematic approach to the reporting of medically relevant findings from whole genome sequencing. BMC Med Genet. 2014 Dec 14; 15:134. PMID: 25714468; PMCID: PMC4342199.
    Citations: 24     Fields:    Translation:Humans
  69. Deo RC, Musso G, Tasan M, Tang P, Poon A, Yuan C, Felix JF, Vasan RS, Beroukhim R, De Marco T, Kwok PY, MacRae CA, Roth FP. Prioritizing causal disease genes using unbiased genomic features. Genome Biol. 2014 Dec 03; 15(12):534. PMID: 25633252; PMCID: PMC4279789.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  70. Asimaki A, Kléber AG, MacRae CA, Saffitz JE. Arrhythmogenic Cardiomyopathy - New Insights into Disease Mechanisms and Drug Discovery. Prog Pediatr Cardiol. 2014 Dec 01; 37(1-2):3-7. PMID: 25506190.
    Citations: 1     
  71. Sun H, Al-Romaih KI, MacRae CA, Pollak MR. Human Kidney Disease-causing INF2 Mutations Perturb Rho/Dia Signaling in the Glomerulus. EBioMedicine. 2014 Dec; 1(2-3):107-15. PMID: 26086034; PMCID: PMC4457406.
    Citations: 8     Fields:    
  72. Guan J, Mishra S, Qiu Y, Shi J, Trudeau K, Las G, Liesa M, Shirihai OS, Connors LH, Seldin DC, Falk RH, MacRae CA, Liao R. Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity. EMBO Mol Med. 2014 Nov; 6(11):1493-507. PMID: 25319546; PMCID: PMC4237473.
    Citations: 23     Fields:    Translation:AnimalsCells
  73. Kong SW, Lee IH, Leshchiner I, Krier J, Kraft P, Rehm HL, Green RC, Kohane IS, MacRae CA. Summarizing polygenic risks for complex diseases in a clinical whole-genome report. Genet Med. 2015 Jul; 17(7):536-44. PMID: 25341114; PMCID: PMC4547452.
    Citations: 11     Fields:    Translation:Humans
  74. Roder K, Werdich AA, Li W, Liu M, Kim TY, Organ-Darling LE, Moshal KS, Hwang JM, Lu Y, Choi BR, MacRae CA, Koren G. RING finger protein RNF207, a novel regulator of cardiac excitation. J Biol Chem. 2014 Dec 05; 289(49):33730-40. PMID: 25281747.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  75. Hariharan V, Asimaki A, Michaelson JE, Plovie E, MacRae CA, Saffitz JE, Huang H. Arrhythmogenic right ventricular cardiomyopathy mutations alter shear response without changes in cell-cell adhesion. Cardiovasc Res. 2014 Nov 01; 104(2):280-9. PMID: 25253076; PMCID: PMC4296114.
    Citations: 8     Fields:    Translation:AnimalsCells
  76. Kim AD, Melick CH, Clements WK, Stachura DL, Distel M, Panáková D, MacRae C, Mork LA, Crump JG, Traver D. Discrete Notch signaling requirements in the specification of hematopoietic stem cells. EMBO J. 2014 Oct 16; 33(20):2363-73. PMID: 25230933; PMCID: PMC4253525.
    Citations: 30     Fields:    Translation:AnimalsCells
  77. Stitziel NO, MacRae CA. A clinical approach to inherited premature coronary artery disease. Circ Cardiovasc Genet. 2014 Aug; 7(4):558-64. PMID: 25140063; PMCID: PMC4403638.
    Citations: 1     Fields:    Translation:Humans
  78. Triedman JK, MacRae C. Searching for a Rosetta Stone: genetic data and clinical patient management. Heart Rhythm. 2014 Oct; 11(10):1714-5. PMID: 25046859.
    Citations:    Fields:    Translation:Humans
  79. Asimaki A, Kapoor S, Plovie E, Karin Arndt A, Adams E, Liu Z, James CA, Judge DP, Calkins H, Churko J, Wu JC, MacRae CA, Kléber AG, Saffitz JE. Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy. Sci Transl Med. 2014 Jun 11; 6(240):240ra74. PMID: 24920660; PMCID: PMC4471875.
    Citations: 52     Fields:    Translation:AnimalsCells
  80. Pieperhoff S, Wilson KS, Baily J, de Mora K, Maqsood S, Vass S, Taylor J, Del-Pozo J, MacRae CA, Mullins JJ, Denvir MA. Heart on a plate: histological and functional assessment of isolated adult zebrafish hearts maintained in culture. PLoS One. 2014; 9(5):e96771. PMID: 24824845; PMCID: PMC4019527.
    Citations: 5     Fields:    Translation:Animals
  81. Arndt AK, MacRae CA. Genetic testing in cardiovascular diseases. Curr Opin Cardiol. 2014 May; 29(3):235-40. PMID: 24717670; PMCID: PMC4129647.
    Citations: 10     Fields:    Translation:Humans
  82. Abrams DJ, Macrae CA. Long QT syndrome. Circulation. 2014 Apr 08; 129(14):1524-9. PMID: 24709866.
    Citations: 3     Fields:    Translation:Humans
  83. Arndt AK, Macrae CA. Genetic testing in cardiovascular diseases. Curr Opin Cardiol. 2014 Mar 25. PMID: 24675013.
    Citations:    Fields:    
  84. Vassy JL, Lautenbach DM, McLaughlin HM, Kong SW, Christensen KD, Krier J, Kohane IS, Feuerman LZ, Blumenthal-Barby J, Roberts JS, Lehmann LS, Ho CY, Ubel PA, MacRae CA, Seidman CE, Murray MF, McGuire AL, Rehm HL, Green RC. The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine. Trials. 2014 Mar 20; 15:85. PMID: 24645908; PMCID: PMC4113228.
    Citations: 42     Fields:    Translation:Humans
  85. MacRae CA, Vasan RS. Clinically relevant functional annotation of genotype. Circ Cardiovasc Genet. 2014 Feb; 7(1):2-3. PMID: 24550428; PMCID: PMC4188549.
    Citations:    Fields:    Translation:Humans
  86. Zhao L, Borikova AL, Ben-Yair R, Guner-Ataman B, MacRae CA, Lee RT, Burns CG, Burns CE. Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1403-8. PMID: 24474765; PMCID: PMC3910613.
    Citations: 32     Fields:    Translation:AnimalsCells
  87. Arndt AK, Macrae CA, Klaassen S. Reponse to De Leeuw and Houge. Am J Hum Genet. 2014 Jan 02; 94(1):154-5. PMID: 24387996; PMCID: PMC3882908.
    Citations: 1     Fields:    Translation:HumansAnimals
  88. Musso G, Tasan M, Mosimann C, Beaver JE, Plovie E, Carr LA, Chua HN, Dunham J, Zuberi K, Rodriguez H, Morris Q, Zon L, Roth FP, MacRae CA. Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish. Development. 2014 Jan; 141(1):224-35. PMID: 24346703; PMCID: PMC3865760.
    Citations: 10     Fields:    Translation:AnimalsCells
  89. Becker JR, Chatterjee S, Robinson TY, Bennett JS, Panáková D, Galindo CL, Zhong L, Shin JT, Coy SM, Kelly AE, Roden DM, Lim CC, MacRae CA. Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development. 2014 Jan; 141(2):335-45. PMID: 24353062; PMCID: PMC3879815.
    Citations: 14     Fields:    Translation:AnimalsCells
  90. MacRae CA. Mendelian forms of structural cardiovascular disease. Curr Cardiol Rep. 2013 Oct; 15(10):399. PMID: 24046092; PMCID: PMC3884814.
    Citations:    Fields:    Translation:HumansAnimals
  91. Icli B, Wara AK, Moslehi J, Sun X, Plovie E, Cahill M, Marchini JF, Schissler A, Padera RF, Shi J, Cheng HW, Raghuram S, Arany Z, Liao R, Croce K, MacRae C, Feinberg MW. MicroRNA-26a regulates pathological and physiological angiogenesis by targeting BMP/SMAD1 signaling. Circ Res. 2013 Nov 08; 113(11):1231-41. PMID: 24047927; PMCID: PMC4068743.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  92. Kapur S, Macrae CA. The developmental basis of adult arrhythmia: atrial fibrillation as a paradigm. Front Physiol. 2013 Sep 12; 4:221. PMID: 24062689; PMCID: PMC3771314.
    Citations: 3     
  93. Guan J, Mishra S, Shi J, Plovie E, Qiu Y, Cao X, Gianni D, Jiang B, Del Monte F, Connors LH, Seldin DC, Lavatelli F, Rognoni P, Palladini G, Merlini G, Falk RH, Semigran MJ, Dec GW, Macrae CA, Liao R. Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity. Basic Res Cardiol. 2013 Sep; 108(5):378. PMID: 23982491; PMCID: PMC3914405.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  94. Huang CJ, Wilson V, Pennings S, MacRae CA, Mullins J. Sequential effects of spadetail, one-eyed pinhead and no tail on midline convergence of nephric primordia during zebrafish embryogenesis. Dev Biol. 2013 Dec 15; 384(2):290-300. PMID: 23860396.
    Citations: 2     Fields:    Translation:Animals
  95. Arndt AK, Schafer S, Drenckhahn JD, Sabeh MK, Plovie ER, Caliebe A, Klopocki E, Musso G, Werdich AA, Kalwa H, Heinig M, Padera RF, Wassilew K, Bluhm J, Harnack C, Martitz J, Barton PJ, Greutmann M, Berger F, Hubner N, Siebert R, Kramer HH, Cook SA, MacRae CA, Klaassen S. Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy. Am J Hum Genet. 2013 Jul 11; 93(1):67-77. PMID: 23768516; PMCID: PMC3710750.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  96. Jay SM, Murthy AC, Hawkins JF, Wortzel JR, Steinhauser ML, Alvarez LM, Gannon J, Macrae CA, Griffith LG, Lee RT. An engineered bivalent neuregulin protects against doxorubicin-induced cardiotoxicity with reduced proneoplastic potential. Circulation. 2013 Jul 09; 128(2):152-61. PMID: 23757312; PMCID: PMC3753575.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  97. Macrae C. The author's reply. Heart. 2013 Sep; 99(18):1374. PMID: 23716569.
    Citations:    Fields:    Translation:Humans
  98. Valente AM, Lakdawala NK, Powell AJ, Evans SP, Cirino AL, Orav EJ, MacRae CA, Colan SD, Ho CY. Comparison of echocardiographic and cardiac magnetic resonance imaging in hypertrophic cardiomyopathy sarcomere mutation carriers without left ventricular hypertrophy. Circ Cardiovasc Genet. 2013 Jun; 6(3):230-7. PMID: 23690394; PMCID: PMC3974911.
    Citations: 9     Fields:    Translation:HumansCells
  99. Mishra S, Guan J, Plovie E, Seldin DC, Connors LH, Merlini G, Falk RH, MacRae CA, Liao R. Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death, and early mortality in zebrafish. Am J Physiol Heart Circ Physiol. 2013 Jul 01; 305(1):H95-103. PMID: 23624626; PMCID: PMC3727100.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  100. Kolpa HJ, Peal DS, Lynch SN, Giokas AC, Ghatak S, Misra S, Norris RA, Macrae CA, Markwald RR, Ellinor P, Bischoff J, Milan DJ. miR-21 represses Pdcd4 during cardiac valvulogenesis. Development. 2013 May; 140(10):2172-80. PMID: 23578931.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  101. Nath AK, Roberts LD, Liu Y, Mahon SB, Kim S, Ryu JH, Werdich A, Januzzi JL, Boss GR, Rockwood GA, MacRae CA, Brenner M, Gerszten RE, Peterson RT. Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. FASEB J. 2013 May; 27(5):1928-38. PMID: 23345455; PMCID: PMC3633825.
    Citations: 13     Fields:    Translation:HumansAnimals
  102. MacRae CA. Recent advances in in vivo screening for antiarrhythmic drugs. Expert Opin Drug Discov. 2013 Feb; 8(2):131-41. PMID: 23311759.
    Citations: 1     Fields:    Translation:HumansAnimals
  103. Peterson RT, Macrae CA. Changing the Scale and Efficiency of Chemical Warfare Countermeasure Discovery Using the Zebrafish. Drug Discov Today Dis Models. 2013; 10(1). PMID: 24273586.
    Citations:    
  104. MacRae CA. Action and the actionability in exome variation. Circ Cardiovasc Genet. 2012 Dec; 5(6):597-8. PMID: 23250897; PMCID: PMC3834266.
    Citations: 4     Fields:    Translation:HumansCells
  105. Jin S, Sarkar KS, Jin YN, Liu Y, Kokel D, Van Ham TJ, Roberts LD, Gerszten RE, Macrae CA, Peterson RT. An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action. J Biomol Screen. 2013 Jan; 18(1):108-15. PMID: 22960781.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  106. MacRae CA. Pattern recognition: combining informatics and genetics to re-evaluate conduction disease. Heart. 2012 Sep; 98(17):1263-4. PMID: 22875820.
    Citations:    Fields:    Translation:Humans
  107. Werdich AA, Brzezinski A, Jeyaraj D, Khaled Sabeh M, Ficker E, Wan X, McDermott BM, Macrae CA, Rosenbaum DS. The zebrafish as a novel animal model to study the molecular mechanisms of mechano-electrical feedback in the heart. Prog Biophys Mol Biol. 2012 Oct-Nov; 110(2-3):154-65. PMID: 22835662.
    Citations: 13     Fields:    Translation:HumansAnimals
  108. Rothman RD, Baggish AL, O'Callaghan C, Lowry PA, Bhatt AB, MacRae CA, Yannekis G, Sanborn DM, Mela T, Yeh RW, Palacios I, Vlahakes GJ, Fifer MA. Management strategy in 249 consecutive patients with obstructive hypertrophic cardiomyopathy referred to a dedicated program. Am J Cardiol. 2012 Oct 15; 110(8):1169-74. PMID: 22766229.
    Citations:    Fields:    Translation:Humans
  109. Ashley EA, Hershberger RE, Caleshu C, Ellinor PT, Garcia JG, Herrington DM, Ho CY, Johnson JA, Kittner SJ, Macrae CA, Mudd-Martin G, Rader DJ, Roden DM, Scholes D, Sellke FW, Towbin JA, Van Eyk J, Worrall BB. Genetics and cardiovascular disease: a policy statement from the American Heart Association. Circulation. 2012 Jul 03; 126(1):142-57. PMID: 22645291; PMCID: PMC3721666.
    Citations: 21     Fields:    Translation:Humans
  110. Guo W, Schafer S, Greaser ML, Radke MH, Liss M, Govindarajan T, Maatz H, Schulz H, Li S, Parrish AM, Dauksaite V, Vakeel P, Klaassen S, Gerull B, Thierfelder L, Regitz-Zagrosek V, Hacker TA, Saupe KW, Dec GW, Ellinor PT, MacRae CA, Spallek B, Fischer R, Perrot A, Özcelik C, Saar K, Hubner N, Gotthardt M. RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. Nat Med. 2012 May; 18(5):766-73. PMID: 22466703; PMCID: PMC3569865.
    Citations: 126     Fields:    Translation:HumansAnimalsCells
  111. Sabeh MK, Kekhia H, Macrae CA. Optical mapping in the developing zebrafish heart. Pediatr Cardiol. 2012 Aug; 33(6):916-22. PMID: 22460358.
    Citations: 4     Fields:    Translation:Animals
  112. Rider SA, Tucker CS, del-Pozo J, Rose KN, MacRae CA, Bailey MA, Mullins JJ. Techniques for the in vivo assessment of cardio-renal function in zebrafish (Danio rerio) larvae. J Physiol. 2012 Apr 15; 590(8):1803-9. PMID: 22331420; PMCID: PMC3573304.
    Citations: 19     Fields:    Translation:Animals
  113. Becker JR, Robinson TY, Sachidanandan C, Kelly AE, Coy S, Peterson RT, MacRae CA. In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling. Cardiovasc Res. 2012 Mar 01; 93(3):463-70. PMID: 22198505.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  114. Lee MS, Macrae CA. Revisiting risk stratification in hypertrophic cardiomyopathy: do we need to start from scratch? Heart Rhythm. 2012 Jan; 9(1):64-5. PMID: 22019864.
    Citations: 2     Fields:    Translation:HumansCells
  115. Peterson RT, Macrae CA. Systematic approaches to toxicology in the zebrafish. Annu Rev Pharmacol Toxicol. 2012; 52:433-53. PMID: 22017682.
    Citations: 40     Fields:    Translation:AnimalsCells
  116. Refaat MM, Lubitz SA, Makino S, Islam Z, Frangiskakis JM, Mehdi H, Gutmann R, Zhang ML, Bloom HL, MacRae CA, Dudley SC, Shalaby AA, Weiss R, McNamara DM, London B, Ellinor PT. Genetic variation in the alternative splicing regulator RBM20 is associated with dilated cardiomyopathy. Heart Rhythm. 2012 Mar; 9(3):390-6. PMID: 22004663; PMCID: PMC3516872.
    Citations: 31     Fields:    Translation:HumansCells
  117. Jeffs L, Rose D, Macrae C, Maione M, Macmillan KM. What near misses tell us about risk and safety in mental health care. J Psychiatr Ment Health Nurs. 2012 Jun; 19(5):430-7. PMID: 22070194.
    Citations:    Fields:    Translation:Humans
  118. MacRae CA, Vasan RS. Next-generation genome-wide association studies: time to focus on phenotype? Circ Cardiovasc Genet. 2011 Aug 01; 4(4):334-6. PMID: 21846867; PMCID: PMC3187849.
    Citations: 9     Fields:    Translation:HumansCells
  119. Wang J, Panáková D, Kikuchi K, Holdway JE, Gemberling M, Burris JS, Singh SP, Dickson AL, Lin YF, Sabeh MK, Werdich AA, Yelon D, Macrae CA, Poss KD. The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Development. 2011 Aug; 138(16):3421-30. PMID: 21752928.
    Citations: 98     Fields:    Translation:AnimalsCells
  120. Wythe JD, Jurynec MJ, Urness LD, Jones CA, Sabeh MK, Werdich AA, Sato M, Yost HJ, Grunwald DJ, Macrae CA, Li DY. Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish. Dis Model Mech. 2011 Sep; 4(5):607-21. PMID: 21628396.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  121. Naunheim MR, Walcott BP, Nahed BV, MacRae CA, Levinson JR, Ogilvy CS. Arterial tortuosity syndrome with multiple intracranial aneurysms: a case report. Arch Neurol. 2011 Mar; 68(3):369-71. PMID: 21403023.
    Citations: 4     Fields:    Translation:Humans
  122. Becker JR, Deo RC, Werdich AA, Panàkovà D, Coy S, MacRae CA. Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish. Dis Model Mech. 2011 May; 4(3):400-10. PMID: 21245263; PMCID: PMC3097461.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  123. Boström P, Mann N, Wu J, Quintero PA, Plovie ER, Panáková D, Gupta RK, Xiao C, MacRae CA, Rosenzweig A, Spiegelman BM. C/EBPß controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell. 2010 Dec 23; 143(7):1072-83. PMID: 21183071; PMCID: PMC3035164.
    Citations: 100     Fields:    Translation:AnimalsCells
  124. Deo RC, MacRae CA. Clinical screening and genetic testing. Clin Lab Med. 2010 Dec; 30(4):775-84. PMID: 20832651; PMCID: PMC4308415.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  125. Assimes TL, Hólm H, Kathiresan S, Reilly MP, Thorleifsson G, Voight BF, Erdmann J, Willenborg C, Vaidya D, Xie C, Patterson CC, Morgan TM, Burnett MS, Li M, Hlatky MA, Knowles JW, Thompson JR, Absher D, Iribarren C, Go A, Fortmann SP, Sidney S, Risch N, Tang H, Myers RM, Berger K, Stoll M, Shah SH, Thorgeirsson G, Andersen K, Havulinna AS, Herrera JE, Faraday N, Kim Y, Kral BG, Mathias RA, Ruczinski I, Suktitipat B, Wilson AF, Yanek LR, Becker LC, Linsel-Nitschke P, Lieb W, König IR, Hengstenberg C, Fischer M, Stark K, Reinhard W, Winogradow J, Grassl M, Grosshennig A, Preuss M, Schreiber S, Wichmann HE, Meisinger C, Yee J, Friedlander Y, Do R, Meigs JB, Williams G, Nathan DM, MacRae CA, Qu L, Wilensky RL, Matthai WH, Qasim AN, Hakonarson H, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Knouff CW, Waterworth DM, Walker MC, Mooser VE, Marrugat J, Lucas G, Subirana I, Sala J, Ramos R, Martinelli N, Olivieri O, Trabetti E, Malerba G, Pignatti PF, Guiducci C, Mirel D, Parkin M, Hirschhorn JN, Asselta R, Duga S, Musunuru K, Daly MJ, Purcell S, Eifert S, Braund PS, Wright BJ, Balmforth AJ, Ball SG, Ouwehand WH, Deloukas P, Scholz M, Cambien F, Huge A, Scheffold T, Salomaa V, Girelli D, Granger CB, Peltonen L, McKeown PP, Altshuler D, Melander O, Devaney JM, Epstein SE, Rader DJ, Elosua R, Engert JC, Anand SS, Hall AS, Ziegler A, O'Donnell CJ, Spertus JA, Siscovick D, Schwartz SM, Becker D, Thorsteinsdottir U, Stefansson K, Schunkert H, Samani NJ, Quertermous T. Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol. 2010 Nov 02; 56(19):1552-63. PMID: 20933357.
    Citations: 35     Fields:    Translation:Humans
  126. Sogah VM, Serluca FC, Fishman MC, Yelon DL, Macrae CA, Mably JD. Distinct troponin C isoform requirements in cardiac and skeletal muscle. Dev Dyn. 2010 Nov; 239(11):3115-23. PMID: 20925115; PMCID: PMC2965274.
    Citations: 7     Fields:    Translation:Animals
  127. Deo RC, MacRae CA. The zebrafish: scalable in vivo modeling for systems biology. Wiley Interdiscip Rev Syst Biol Med. 2011 May-Jun; 3(3):335-46. PMID: 20882534; PMCID: PMC3251331.
    Citations: 11     Fields:    Translation:Animals
  128. Panáková D, Werdich AA, Macrae CA. Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel. Nature. 2010 Aug 12; 466(7308):874-8. PMID: 20657579.
    Citations: 45     Fields:    Translation:AnimalsCells
  129. Macrae CA. Cardiac Arrhythmia: In vivo screening in the zebrafish to overcome complexity in drug discovery. Expert Opin Drug Discov. 2010 Jul; 5(7):619-632. PMID: 20835353.
    Citations: 9     Fields:    
  130. MacRae CA. Utility of Genetic Testing in Long QT Syndrome. Circulation. 2010 Jun 15; 121(23):e440. PMID: 25197101.
    Citations:    Fields:    
  131. Sabeh MK, MacRae CA. The genetics of atrial fibrillation. Curr Opin Cardiol. 2010 May; 25(3):186-91. PMID: 20224389.
    Citations: 4     Fields:    Translation:Humans
  132. Albert CM, MacRae CA, Chasman DI, VanDenburgh M, Buring JE, Manson JE, Cook NR, Newton-Cheh C. Common variants in cardiac ion channel genes are associated with sudden cardiac death. Circ Arrhythm Electrophysiol. 2010 Jun; 3(3):222-9. PMID: 20400777; PMCID: PMC2891421.
    Citations: 25     Fields:    Translation:Humans
  133. Shin JT, Pomerantsev EV, Mably JD, MacRae CA. High-resolution cardiovascular function confirms functional orthology of myocardial contractility pathways in zebrafish. Physiol Genomics. 2010 Jul 07; 42(2):300-9. PMID: 20388839; PMCID: PMC3032279.
    Citations: 18</