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Gyorgy Baffy, PH.D., PH.D., M.D.

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Biography
1990
OMGE Young Investigator Scholarship
1991 - 1993
NIH Fogarty Fellow
1994
Rolf Madaus Prize
2010
Geza Hetenyi Award
2014 - 2015
US Fulbright Scholar Award
2017
Pro Optimo Merito in Gastroenterologia

Overview
Dr. Gyorgy Baffy is an Associate Professor of Medicine at Harvard Medical School and Chief of Gastroenterology at the VA Boston Healthcare System. He is a graduate of the University Medical School of Debrecen in Hungary. His PhD derives from studies on growth factor-mediated calcium signaling as an NIH Fogarty Fellow in the Department of Biochemistry and Biophysics at the University of Pennsylvania. He trained in gastroenterology at the University of Michigan and the Brigham and Women’s Hospital. His research interests focus on various aspects of nonalcoholic fatty liver disease such as outcomes prediction, biomarkers of lipotoxicity, metabolic reprogramming, cancer bioenergetics, and development of portal hypertension and hepatocellular carcinoma. He has been involved in various clinical trials that pertain to colorectal cancer screening. He organized multiple workshops and symposia at major US conferences. He published over 70 peer-reviewed papers and book chapters. He has participated in numerous scientific review panels and provides editorial work for several journals in gastroenterology and hepatology. In 2014, he received a Fulbright US Scholar award to teach for a semester about obesity and related disorders at the University of Debrecen. He is a Fellow of the American College of Physicians, American College of Gastroenterology, American Gastroenterological Association, and the American Association for the Study of Liver Diseases. He is the recipient of the Madaus Prize from the Madaus Liver Foundation and the Hetényi Medal and Pro Optimo Merito in Gastroenterologia Award from the Hungarian Gastroenterological Association.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. PAL-LIVER (NAVARRO, VICTOR) Oct 1, 2017 - Sep 30, 2022
    Patient-Centered Outcomes Research Institute (PCORI)
    Introducing palliative care with the treatment of end stage liver disease: A randomized controlled trial
    Role Description: The main goal of this multicenter cluster randomized clinical project is to determine the benefits of hepatologist-led palliative care compared to the conventional approach of requesting palliative care consultations in the management of patients with end-stage liver disease
    Role: Site Investigator
  2. W81XWH-17-1-0428 (TSENG, YU-HUA) May 1, 2017 - Apr 30, 2020
    Department of Defense
    Identification of novel lipid mediators with anti-diabetic effect
    Role Description: The goal of this study is to explore the impact of brown fat tissue-derived lipid mediators induced by intermittent cold exposure on the development and progression of type 2 diabetes
    Role: Co-PI
  3. CSP-577 (DOMINITZ, JASON / ROBERTSON, DOUGLAS) May 1, 2012 - Sep 30, 2027
    VA Cooperative Studies
    Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM)
    Role Description: The main goal of this study is to perform a large, simple, multicenter, randomized, parallel group trial directly comparing screening colonoscopy with annual fecal immunochemistry test (FIT) screening in 50,000 average risk individuals and determine whether colonoscopy is superior to FIT in the prevention of colorectal cancer mortality measured over 10 years.
    Role: Local Site Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Baffy G. Digital Rectal Examination: Is It Warranted in the Endoscopy Suite? Am J Gastroenterol. 2019 Feb; 114(2):355. PMID: 30361620.
    Citations:    Fields:    
  2. Baffy G. Potential mechanisms linking gut microbiota and portal hypertension. Liver Int. 2019 Apr; 39(4):598-609. PMID: 30312513.
    Citations:    Fields:    
  3. Andolfi C, Baffy G, Fisichella PM. Whose patient is it? The path to multidisciplinary management of achalasia. J Surg Res. 2018 08; 228:8-13. PMID: 29907234.
    Citations:    Fields:    
  4. Baffy G. Origins of Portal Hypertension in Nonalcoholic Fatty Liver Disease. Dig Dis Sci. 2018 Mar; 63(3):563-576. PMID: 29368124.
    Citations: 1     Fields:    Translation:Humans
  5. Sarkar M, Baffy G. Perinatal programming of adolescent nonalcoholic fatty liver disease: A case for gender inequality? Hepatology. 2018 01; 67(1):7-9. PMID: 28771759.
    Citations:    Fields:    Translation:Humans
  6. Dominitz JA, Robertson DJ, Ahnen DJ, Allison JE, Antonelli M, Boardman KD, Ciarleglio M, Del Curto BJ, Huang GD, Imperiale TF, Larson MF, Lieberman D, O'Connor T, O'Leary TJ, Peduzzi P, Provenzale D, Shaukat A, Sultan S, Voorhees A, Wallace R, Guarino PD. Colonoscopy vs. Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM): Rationale for Study Design. Am J Gastroenterol. 2017 Nov; 112(11):1736-1746. PMID: 29016565.
    Citations: 2     Fields:    Translation:Humans
  7. Baffy G, Fisichella PM. Gastrointestinal Surgery and Endoscopy: Recent Trends in Competition and Collaboration. Clin Gastroenterol Hepatol. 2017 06; 15(6):799-803. PMID: 28235574.
    Citations:    Fields:    
  8. Baffy G. Mitochondrial uncoupling in cancer cells: Liabilities and opportunities. Biochim Biophys Acta Bioenerg. 2017 Aug; 1858(8):655-664. PMID: 28088333.
    Citations: 1     Translation:HumansAnimalsCells
  9. Karagozian R, Bhardwaj G, Wakefield DB, Baffy G. Obesity paradox in advanced liver disease: obesity is associated with lower mortality in hospitalized patients with cirrhosis. Liver Int. 2016 10; 36(10):1450-6. PMID: 27037497.
    Citations: 3     Fields:    Translation:Humans
  10. Tarnoki AD, Tarnoki DL, Littvay L, Garami Z, Molnar AA, Berczi V, Karlinger K, Baffy G. Environmental Factors Responsible for Variability of Hepatic Vein Flow: A Doppler Assessment in Healthy Twins. Chin J Physiol. 2016 Feb 29; 59(1):33-8. PMID: 26875560.
    Citations:    Fields:    Translation:Humans
  11. Baffy G. Centr Eur J Gastroenterol Hepatol. Novel strategies in the pharmacotherapy of nonalcoholic fatty liver disease. 2016; 2:54-60. View Publication.
  12. Baffy G. MicroRNAs in Nonalcoholic Fatty Liver Disease. J Clin Med. 2015 Dec 04; 4(12):1977-88. PMID: 26690233.
    Citations: 7     
  13. Imler TD, Morea J, Kahi C, Cardwell J, Johnson CS, Xu H, Ahnen D, Antaki F, Ashley C, Baffy G, Cho I, Dominitz J, Hou J, Korsten M, Nagar A, Promrat K, Robertson D, Saini S, Shergill A, Smalley W, Imperiale TF. Corrigendum: Multi-Center Colonoscopy Quality Measurement Utilizing Natural Language Processing. Am J Gastroenterol. 2015 Dec; 110(12):1743. PMID: 26673514.
    Citations:    Fields:    
  14. Rodriguez-Diaz E, Baffy G, Singh SK. Probe-based confocal laser endomicroscopy quantitative morphometric markers associated with portal hypertension in duodenal mucosa. Liver Int. 2016 Feb; 36(2):223-31. PMID: 26133980.
    Citations: 1     Fields:    Translation:Humans
  15. Baffy G. Decoding multifocal hepatocellular carcinoma: an opportune pursuit. Hepatobiliary Surg Nutr. 2015 Jun; 4(3):206-10. PMID: 26151061.
    Citations: 2     
  16. Imler TD, Morea J, Kahi C, Sherer EA, Cardwell J, Johnson CS, Xu H, Ahnen D, Antaki F, Ashley C, Baffy G, Cho I, Dominitz J, Hou J, Korsten M, Nagar A, Promrat K, Robertson D, Saini S, Shergill A, Smalley W, Imperiale TF. Multi-center colonoscopy quality measurement utilizing natural language processing. Am J Gastroenterol. 2015 Apr; 110(4):543-52. PMID: 25756240.
    Citations: 11     Fields:    Translation:Humans
  17. Tarnoki AD, Tarnoki DL, Baffy G. Response to the letter entitled "Bioimpedance analysis--the shortcomings". Obes Res Clin Pract. 2014 Sep-Oct; 8(5):e511-2. PMID: 25081810.
    Citations:    Fields:    Translation:Humans
  18. Tarnoki AD, Tarnoki DL, Medda E, Cotichini R, Stazi MA, Fagnani C, Nisticà L, Lucatelli P, Boatta E, Zini C, Fanelli F, Baracchini C, Meneghetti G, Schillaci G, Osztovits J, Jermendy G, Kiss RB, Prà da IN, Karlinger K, Lannert A, Metneki J, Molnar AA, Garami Z, Berczi V, Halasz I, Baffy G. Bioimpedance analysis of body composition in an international twin cohort. Obes Res Clin Pract. 2014 May-Jun; 8(3):e201-98. PMID: 24847671.
    Citations: 3     Fields:    Translation:Humans
  19. Baffy G, Loscalzo J. Complexity and network dynamics in physiological adaptation: an integrated view. Physiol Behav. 2014 May 28; 131:49-56. PMID: 24751342.
    Citations: 5     Fields:    Translation:HumansAnimals
  20. Karagozian R, Derdák Z, Baffy G. Obesity-associated mechanisms of hepatocarcinogenesis. Metabolism. 2014 May; 63(5):607-17. PMID: 24629562.
    Citations: 38     Fields:    Translation:HumansAnimals
  21. Baffy G. Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: Epidemiology, Pathogenesis, and Prevention. J Clin Transl Hepatol. 2013 Dec; 1(2):131-7. PMID: 26355775.
    Citations:    
  22. Karagozian R, Baker E, Houranieh A, Leavitt D, Baffy G. Risk profile of hepatocellular carcinoma reveals dichotomy among US veterans. J Gastrointest Cancer. 2013 Sep; 44(3):318-24. PMID: 23609167.
    Citations: 2     Fields:    Translation:HumansCells
  23. Baffy G. The impact of network medicine in gastroenterology and hepatology. Clin Gastroenterol Hepatol. 2013 Oct; 11(10):1240-4. PMID: 23932906.
    Citations: 2     Fields:    Translation:Humans
  24. Tarnoki AD, Tarnoki DL, Bogl LH, Medda E, Fagnani C, Nisticò L, Stazi MA, Brescianini S, Lucatelli P, Boatta E, Zini C, Fanelli F, Baracchini C, Meneghetti G, Osztovits J, Jermendy G, Kiss RG, Preda I, Karlinger K, Lannert A, Molnar AA, Littvay L, Garami Z, Berczi V, Pucci G, Baffy G, Schillaci G, Pietiläinen KH. Association of body mass index with arterial stiffness and blood pressure components: a twin study. Atherosclerosis. 2013 Aug; 229(2):388-95. PMID: 23880193.
    Citations: 6     Fields:    Translation:Humans
  25. Sun X, Han L, Seth P, Bian S, Li L, Csizmadia E, Junger WG, Schmelzle M, Usheva A, Tapper EB, Baffy G, Sukhatme VP, Wu Y, Robson SC. Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/ENTPD1 null mice. Hepatology. 2013 Jan; 57(1):205-16. PMID: 22859060.
    Citations: 19     Fields:    Translation:AnimalsCells
  26. Baffy G. Allostasis in nonalcoholic fatty liver disease: implications for risk assessment. Dig Dis Sci. 2013 Feb; 58(2):302-8. PMID: 22886595.
    Citations: 2     Fields:    Translation:Humans
  27. Tarnoki AD, Tarnoki DL, Bata P, Littvay L, Osztovits J, Jermendy G, Karlinger K, Lannert A, Preda I, Kiss RG, Molnar AA, Garami Z, Baffy G, Berczi V. Heritability of non-alcoholic fatty liver disease and association with abnormal vascular parameters: a twin study. Liver Int. 2012 Sep; 32(8):1287-93. PMID: 22651705.
    Citations: 10     Fields:    Translation:Humans
  28. Baffy G, Brunt EM, Caldwell SH. Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. J Hepatol. 2012 Jun; 56(6):1384-91. PMID: 22326465.
    Citations: 196     Fields:    Translation:Humans
  29. Baffy G. Editorial: hepatocellular carcinoma in type 2 diabetes: more than meets the eye. Am J Gastroenterol. 2012 Jan; 107(1):53-5. PMID: 22218030.
    Citations: 8     Fields:    Translation:Humans
  30. Baffy G, Derdak Z, Robson SC. Mitochondrial recoupling: a novel therapeutic strategy for cancer? Br J Cancer. 2011 Aug 09; 105(4):469-74. PMID: 21712825.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  31. Baffy G. Negative outcomes for intraoperative blood transfusion in patients with advanced cirrhosis: post hoc ergo propter hoc? Clin Gastroenterol Hepatol. 2010 Nov; 8(11):996. PMID: 20541626.
    Citations:    Fields:    Translation:Humans
  32. Baffy G. Uncoupling protein-2 and cancer. Mitochondrion. 2010 Apr; 10(3):243-52. PMID: 20005987.
    Citations: 32     Fields:    Translation:HumansCells
  33. Okpara N, Aswad B, Baffy G. Eosinophilic colitis. World J Gastroenterol. 2009 Jun 28; 15(24):2975-9. PMID: 19554649.
    Citations: 13     Fields:    Translation:Humans
  34. Baffy G. Kupffer cells in non-alcoholic fatty liver disease: the emerging view. J Hepatol. 2009 Jul; 51(1):212-23. PMID: 19447517.
    Citations: 125     Fields:    Translation:HumansAnimalsCells
  35. Derdak Z, Garcia TA, Baffy G. Detection of uncoupling protein-2 (UCP2) as a mitochondrial modulator of apoptosis. Methods Mol Biol. 2009; 559:205-17. PMID: 19609759.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  36. Derdak Z, Mark NM, Beldi G, Robson SC, Wands JR, Baffy G. The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells. Cancer Res. 2008 Apr 15; 68(8):2813-9. PMID: 18413749.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  37. Sheets AR, Fülöp P, Derdák Z, Kassai A, Sabo E, Mark NM, Paragh G, Wands JR, Baffy G. Uncoupling protein-2 modulates the lipid metabolic response to fasting in mice. Am J Physiol Gastrointest Liver Physiol. 2008 Apr; 294(4):G1017-24. PMID: 18292186.
    Citations: 12     Fields:    Translation:AnimalsCells
  38. Fülöp P, Derdák Z, Sheets A, Sabo E, Berthiaume EP, Resnick MB, Wands JR, Paragh G, Baffy G. Lack of UCP2 reduces Fas-mediated liver injury in ob/ob mice and reveals importance of cell-specific UCP2 expression. Hepatology. 2006 Sep; 44(3):592-601. PMID: 16941708.
    Citations: 16     Fields:    Translation:AnimalsCells
  39. Hyatt P, Resnick M, Habr F, Baffy G. Brunner's gland hamartoma. Clin Gastroenterol Hepatol. 2006 Jul; 4(7):A26. PMID: 16630774.
    Citations:    Fields:    Translation:Humans
  40. Derdák Z, Fülöp P, Sabo E, Tavares R, Berthiaume EP, Resnick MB, Paragh G, Wands JR, Baffy G. Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-kappaB activation and oxidative stress. Carcinogenesis. 2006 May; 27(5):956-61. PMID: 16401637.
    Citations: 17     Fields:    Translation:Animals
  41. Baffy G. Uncoupling protein-2 and non-alcoholic fatty liver disease. Front Biosci. 2005 Sep 01; 10:2082-96. PMID: 15970480.
    Citations: 17     Fields:    Translation:HumansAnimals
  42. Horimoto M, Resnick MB, Konkin TA, Routhier J, Wands JR, Baffy G. Expression of uncoupling protein-2 in human colon cancer. Clin Cancer Res. 2004 Sep 15; 10(18 Pt 1):6203-7. PMID: 15448008.
    Citations: 39     Fields:    Translation:HumansCells
  43. Horimoto M, Fülöp P, Derdák Z, Wands JR, Baffy G. Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in mice. Hepatology. 2004 Feb; 39(2):386-92. PMID: 14767991.
    Citations: 28     Fields:    Translation:AnimalsCells
  44. Baffy G, Zhang CY, Glickman JN, Lowell BB. Obesity-related fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2. Hepatology. 2002 Apr; 35(4):753-61. PMID: 11915020.
    Citations: 17     Fields:    Translation:AnimalsCells
  45. Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell. 2001 Jun 15; 105(6):745-55. PMID: 11440717.
    Citations: 188     Fields:    Translation:HumansAnimals
  46. Jacobson BC, Strate L, Baffy G, Huang L, Mutinga M, Banks PA. The nature of after-hours telephone medical practice by GI fellows. Am J Gastroenterol. 2001 Feb; 96(2):570-3. PMID: 11232709.
    Citations:    Fields:    Translation:Humans
  47. Baffy G, Boyle JM. Association of Zollinger-Ellison syndrome with pancreatitis: report of five cases. Dig Dis Sci. 2000 Aug; 45(8):1531-4. PMID: 11007101.
    Citations:    Fields:    Translation:Humans
  48. Várvölgyi C, Balogh Z, Bodnár Z, Eke E, Baffy G. Small-unit colonoscopy and quality assurance. Endoscopy. 2000 Jun; 32(6):504. PMID: 10863925.
    Citations:    Fields:    Translation:Humans
  49. Baffy G, Strate LL, Krnsky ML. Image of the month. Adherent, yellow exudate speckled with black spots in the distal two thirds of the esophagus. Diagnosis: This distinctive endoscopic image shows an acute necrotizing esophagitis, also known as the black esophagus. Gastroenterology. 2000 Feb; 118(2):252, 453. PMID: 10691371.
    Citations: 3     Fields:    Translation:HumansCells
  50. Baffy G, Sharma K, Shi W, Ziyadeh FN, Williamson JR. Growth arrest of a murine mesangial cell line by transforming growth factor beta 1 is associated with inhibition of mitogen-induced Ca2+ mobilization. Biochem Biophys Res Commun. 1995 May 16; 210(2):378-83. PMID: 7755613.
    Citations:    Fields:    Translation:AnimalsCells
  51. Baffy G, Yang L, Raj S, Manning DR, Williamson JR. G protein coupling to the thrombin receptor in Chinese hamster lung fibroblasts. J Biol Chem. 1994 Mar 18; 269(11):8483-7. PMID: 8132575.
    Citations: 18     Fields:    Translation:AnimalsCells
  52. Baffy G, Yang L, Wolf BA, Williamson JR. G-protein specificity in signaling pathways that mobilize calcium in insulin-secreting beta-TC3 cells. Diabetes. 1993 Dec; 42(12):1878-82. PMID: 8243834.
    Citations: 2     Fields:    Translation:AnimalsCells
  53. Baffy G, Miyashita T, Williamson JR, Reed JC. Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production. J Biol Chem. 1993 Mar 25; 268(9):6511-9. PMID: 8454620.
    Citations: 77     Fields:    Translation:AnimalsCells
  54. Yang L, Camoratto AM, Baffy G, Raj S, Manning DR, Williamson JR. Epidermal growth factor-mediated signaling of G(i)-protein to activation of phospholipases in rat-cultured hepatocytes. J Biol Chem. 1993 Feb 15; 268(5):3739-46. PMID: 8429049.
    Citations: 9     Fields:    Translation:AnimalsCells
  55. Baffy G, Yang L, Michalopoulos GK, Williamson JR. Hepatocyte growth factor induces calcium mobilization and inositol phosphate production in rat hepatocytes. J Cell Physiol. 1992 Nov; 153(2):332-9. PMID: 1429853.
    Citations: 12     Fields:    Translation:Animals
  56. Yang LJ, Baffy G, Rhee SG, Manning D, Hansen CA, Williamson JR. Pertussis toxin-sensitive Gi protein involvement in epidermal growth factor-induced activation of phospholipase C-gamma in rat hepatocytes. J Biol Chem. 1991 Nov 25; 266(33):22451-8. PMID: 1657996.
    Citations: 22     Fields:    Translation:AnimalsCells
  57. Reed JC, Talwar HS, Cuddy M, Baffy G, Williamson J, Rapp UR, Fisher GJ. Mitochondrial protein p26 BCL2 reduces growth factor requirements of NIH3T3 fibroblasts. Exp Cell Res. 1991 Aug; 195(2):277-83. PMID: 2070813.
    Citations: 10     Fields:    Translation:Cells
  58. Baffy G, Varga Z, Fóris G, Leövey A. Disturbed intracellular calcium-related processes of hepatocytes and neutrophils in human alcoholic liver disease. Clin Biochem. 1990 Jun; 23(3):241-5. PMID: 2142639.
    Citations: 1     Fields:    Translation:HumansCells
  59. Sápy P, Baffy G, Garami Z, Országh I. A long-term follow-up study of decompression type operations in chronic pancreatitis. Magy Seb (Hungarian J Surg). 1990; 43:202-7.
  60. Sápy P, Bakó G, Baffy G, Olvasztó S, Balázs G. A comparative study on Whipple-type and pylorus-preserving pancreatoduodenectomies in chronic pancreatitis. Magy Seb (Hungarian J Surg). 1990; 43:286-93.
  61. Baffy G, Várhelyi I, Halász I. [Suspected intestinal perforation during paracentesis of a giant ovarian dermoid cyst]. Orv Hetil. 1988 May 08; 129(19):1001-2. PMID: 3387089.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.