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Charles J. Dimitroff, PH.D.

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Available: 09/06/11, Expires: 10/07/22

My Laboratory is making pioneering observations in two seemingly diverse research areas studying the roles of galectin-1, -3 and -9 and their glycoprotein ligands in adaptive immunity and in melanoma progression. Galectin-binding glycans deliberately displayed on key membrane proteins along with their glyco-enzyme regulators have a profound effect on the capacity of T and B cells to differentiate and function in adaptive immune responses and on the virulency of malignant melanoma. To this end, we have discovered that glycosyltransferase, GCNT2, which catalyzes the synthesis of I-antigen (or I-branched glycans), is a critical negative regulator of Gal-3- and Gal-9-binding activity that profoundly influences B cell immunity and melanoma progression. These findings have wide implications in developing potent immunomodulators of steady-state and pathologic immunity and new methods to treat, and even predict, melanoma progression. An HMS Scholar-in-Medicine trainee would be involved in basic and translational studies designed to better understand the role of GCNT2/I-branches in humoral immunity and/or in melanoma progression.

Available: 12/01/15, Expires: 12/02/19

PROJECT NARRATIVE Development of effective antibody (Ab) immune protection against pathogens is regulated in specialized tissue microenvironments called germinal centers (GC). GCs are dynamic multi-cellular immune domains containing activated B-lymphocytes (GC B cells), which develop into B cells capable of producing potent, long-lasting Abs. Unfortunately, knowledge of how GC B cell surface carbohydrates prime their ability to become effective Ab-producing cells is still poorly understood. In GCs, activated GC B cells, through the assistance of follicular T helper and dendritic cells, actively mutate their Ab receptors and differentiate in B cells capable of producing high affinity Abs. Given that GC B cell receptors and their counter-receptor ligands have been well-described, there is surprisingly little information on how these cell surface molecules are structurally regulated via post-translational glycosylations. Interestingly, a hallmark feature on the GC B cell surface is the stage-specific expression of a glycan moiety T antigen (TAg), known functionally as a regulator of effector T cell fate. Whether TAg or other heretofore unknown glycan determinants, we hypothesize that GC B cells also express discrete glycan moieties that help regulate their fate in GCs and prime their ability to differentiate and transition into high affinity Ab producers. In this exploratory research project, the HMS Scholar-in-Medicine student we will identify signature glycomic features, including membrane glycoprotein scaffolds capable of transmitting survival signals, on native human GC B cells. He/she will employ innovative experimental approaches to study native human pre-GC, GC and post-GC B cells and define the glycomic signature and its impact on GC B cells. Our results will provide new insights on glycosylation programs regulating human B cell differentiation and related development of a humoral immune response. Our findings will also implicate glycomic regulators on GC B cells that could alter autoimmunity and/or B-lymphomagenesis.

Available: 12/01/15, Expires: 12/02/19

PROJECT NARRATIVE for HMS Scholar-in-Medicine student [Open - 12/1/15 – 12/1/19] Cancer cells display aberrant levels of cell surface glycans that often facilitate malignant behavior. Functional expression of these glycans and glycosyltransferases (GlycoT) that synthesize them are linked behaviors associated with cancer progression, including adhesion, invasion, angiogenesis, intravascular trafficking, immune evasion and metastases formation. Therefore, identifying malignancy-associated glycans, and related GlycoT regulators and membrane protein scaffolds could offer new molecular targets for cancer therapy or for biomarkers of malignancy. Our central hypothesis is that acquisition of malignancy-associated glycans is correlated with malignant transformation, cancer virulence and metastatic potential. In preliminary investigations, we performed Gene Set Enrichment Analysis on the glycome of (9) malignancies and found that malignant melanomas exhibit the most statistically-significant expression profile of glycomic genes. To this end, we also obtained striking evidence that glycans on the surface of melanoma cells were fundamentally different than those expressed on normal human epidermal melanocytes (NHEM). Comparative glycomic gene expression profiling between NHEM and melanoma cells revealed conspicuous de-regulation of (2) GlycoTs that can in fact modulate synthesis of identified melanoma-associated glycans. In this exploratory research project, the HMS Scholar-in-Medicine student will leverage these exciting data to investigate the role of identified melanoma-associated glycans and related GlycoT regulators on melanomagenesis and malignant behaviors, including adhesion, invasion, transcription factor/cytokine induction, tumorigenicity and metastasis. The project will lead to new perspectives on how melanomas develop and metastasize. Research directions include but are not limited to (1) Defining malignant-associated glycoconjugates on melanoma cells, (2) Studying regulation of malignancy-associated glycans in melanoma cells and (3) Studying the in vivo role of GlycoTs in melanoma development. Importantly, findings from this research will offer new insights on specific glyco-molecules that may be targeted for cancer therapeutic exploitation or used as biomarkers of melanoma malignancy or predictors of metastasis and clinical outcome.

Defining Melanoma Cell Adhesion Molecule (MCAM) as a Novel Gal-1 Ligand in Melanoma Progression
Summer, 06/13/13 - 08/01/13
Expression Analysis of Galectin-1 Ligands in Melanoma Progression
Full Time, 03/15/12 - 08/06/12

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01CA225644 (DIMITROFF, CHARLES J) May 1, 2019 - Apr 30, 2024
    Analysis of Glycomic Regulators in Melanoma Progression
    Role: Principal Investigator
  2. R21AI125476 (DIMITROFF, CHARLES J) Jul 1, 2016 - Jun 30, 2018
    Glycomic Characterization of Germinal Center B cells
    Role: Principal Investigator
  3. R01CA173610 (DIMITROFF, CHARLES J) Jul 2, 2013 - Apr 30, 2018
    Functional Analysis of Galectin-1 Ligands in Melanoma Progression
    Role: Principal Investigator
  4. R01AT004628 (DIMITROFF, CHARLES J) Dec 1, 2008 - Nov 30, 2012
    Mechanistic Analysis of Anti-inflammatory Activity by Fluorosugars
    Role: Principal Investigator
  5. R01CA118124 (DIMITROFF, CHARLES J) Apr 5, 2007 - Jan 31, 2012
    Analysis of Homing Receptors in Prostate Cancer
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Dimitroff CJ. I-branched carbohydrates as emerging effectors of malignant progression. Proc Natl Acad Sci U S A. 2019 Jun 18. PMID: 31213534.
  2. Giovannone N, Antonopoulos A, Liang J, Geddes Sweeney J, Kudelka MR, King SL, Lee GS, Cummings RD, Dell A, Barthel SR, Widlund HR, Haslam SM, Dimitroff CJ. Human B Cell Differentiation Is Characterized by Progressive Remodeling of O-Linked Glycans. Front Immunol. 2018; 9:2857. PMID: 30619255.
  3. Giovannone N, Smith LK, Treanor B, Dimitroff CJ. Galectin-Glycan Interactions as Regulators of B Cell Immunity. Front Immunol. 2018; 9:2839. PMID: 30564237.
  4. Sweeney JG, Liang J, Antonopoulos A, Giovannone N, Kang S, Mondala TS, Head SR, King SL, Tani Y, Brackett D, Dell A, Murphy GF, Haslam SM, Widlund HR, Dimitroff CJ. Loss of GCNT2/I-branched glycans enhances melanoma growth and survival. Nat Commun. 2018 08 22; 9(1):3368. PMID: 30135430.
    Citations:    Fields:    Translation:HumansAnimalsCells
  5. Giovannone N, Liang J, Antonopoulos A, Geddes Sweeney J, King SL, Pochebit SM, Bhattacharyya N, Lee GS, Dell A, Widlund HR, Haslam SM, Dimitroff CJ. Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans. Nat Commun. 2018 08 17; 9(1):3287. PMID: 30120234.
    Citations:    Fields:    Translation:HumansCells
  6. Dimitroff CJ. Galectin-Binding O-Glycosylations as Regulators of Malignancy. Cancer Res. 2015 Aug 15; 75(16):3195-202. PMID: 26224120.
    Citations: 12     Fields:    Translation:HumansCells
  7. Yazawa EM, Geddes-Sweeney JE, Cedeno-Laurent F, Walley KC, Barthel SR, Opperman MJ, Liang J, Lin JY, Schatton T, Laga AC, Mihm MC, Qureshi AA, Widlund HR, Murphy GF, Dimitroff CJ. Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential. J Invest Dermatol. 2015 Jul; 135(7):1849-1862. PMID: 25756799.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  8. Burdick MM, Reynolds NM, Martin EW, Hawes JV, Carlson GE, Cuckler CM, Bates MC, Barthel SR, Dimitroff CJ. Isolation and characterization of chimeric human Fc-expressing proteins using protein a membrane adsorbers and a streamlined workflow. J Vis Exp. 2014 Jan 08; (83):e51023. PMID: 24429389.
    Citations:    Fields:    Translation:HumansAnimals
  9. Li J, Guillebon AD, Hsu JW, Barthel SR, Dimitroff CJ, Lee YF, King MR. Human fucosyltransferase 6 enables prostate cancer metastasis to bone. Br J Cancer. 2013 Dec 10; 109(12):3014-22. PMID: 24178760.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  10. Dimitroff CJ. Leveraging fluorinated glucosamine action to boost antitumor immunity. Curr Opin Immunol. 2013 Apr; 25(2):206-13. PMID: 23219268.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  11. Barthel SR, Hays DL, Yazawa EM, Opperman M, Walley KC, Nimrichter L, Burdick MM, Gillard BM, Moser MT, Pantel K, Foster BA, Pienta KJ, Dimitroff CJ. Definition of molecular determinants of prostate cancer cell bone extravasation. Cancer Res. 2013 Jan 15; 73(2):942-52. PMID: 23149920.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  12. Cedeno-Laurent F, Dimitroff CJ. Galectins and their ligands: negative regulators of anti-tumor immunity. Glycoconj J. 2012 Dec; 29(8-9):619-25. PMID: 22544342.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  13. Cedeno-Laurent F, Watanabe R, Teague JE, Kupper TS, Clark RA, Dimitroff CJ. Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma. Blood. 2012 Apr 12; 119(15):3534-8. PMID: 22383798.
    Citations: 16     Fields:    Translation:HumansCells
  14. Cedeno-Laurent F, Opperman M, Barthel SR, Kuchroo VK, Dimitroff CJ. Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. J Immunol. 2012 Apr 01; 188(7):3127-37. PMID: 22345665.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  15. Cedeno-Laurent F, Dimitroff CJ. Evidence of a novel galectin-9-binding membrane glycoprotein ligand on T helper cells. Clin Immunol. 2012 Apr; 143(1):6-7. PMID: 22321867.
    Citations:    Fields:    Translation:AnimalsCells
  16. Cedeno-Laurent F, Opperman MJ, Barthel SR, Hays D, Schatton T, Zhan Q, He X, Matta KL, Supko JG, Frank MH, Murphy GF, Dimitroff CJ. Metabolic inhibition of galectin-1-binding carbohydrates accentuates antitumor immunity. J Invest Dermatol. 2012 Feb; 132(2):410-20. PMID: 22158550.
    Citations: 21     Fields:    Translation:AnimalsCells
  17. Cedeno-Laurent F, Dimitroff CJ. Galectin-1 research in T cell immunity: past, present and future. Clin Immunol. 2012 Feb; 142(2):107-16. PMID: 22019770.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  18. Barthel SR, Antonopoulos A, Cedeno-Laurent F, Schaffer L, Hernandez G, Patil SA, North SJ, Dell A, Matta KL, Neelamegham S, Haslam SM, Dimitroff CJ. Peracetylated 4-fluoro-glucosamine reduces the content and repertoire of N- and O-glycans without direct incorporation. J Biol Chem. 2011 Jun 17; 286(24):21717-31. PMID: 21493714.
    Citations: 27     Fields:    Translation:HumansCells
  19. Cedeno-Laurent F, Barthel SR, Opperman MJ, Lee DM, Clark RA, Dimitroff CJ. Development of a nascent galectin-1 chimeric molecule for studying the role of leukocyte galectin-1 ligands and immune disease modulation. J Immunol. 2010 Oct 15; 185(8):4659-72. PMID: 20844192.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  20. Barthel SR, Wiese GK, Cho J, Opperman MJ, Hays DL, Siddiqui J, Pienta KJ, Furie B, Dimitroff CJ. Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19491-6. PMID: 19889975.
    Citations: 51     Fields:    Translation:Humans
  21. Wiese G, Barthel SR, Dimitroff CJ. Analysis of physiologic E-selectin-mediated leukocyte rolling on microvascular endothelium. J Vis Exp. 2009 Feb 11; (24). PMID: 19229187.
    Citations: 18     Fields:    Translation:HumansCells
  22. Barthel SR, Gavino JD, Wiese GK, Jaynes JM, Siddiqui J, Dimitroff CJ. Analysis of glycosyltransferase expression in metastatic prostate cancer cells capable of rolling activity on microvascular endothelial (E)-selectin. Glycobiology. 2008 Oct; 18(10):806-17. PMID: 18647941.
    Citations: 21     Fields:    Translation:HumansCells
  23. Gainers ME, Descheny L, Barthel SR, Liu L, Wurbel MA, Dimitroff CJ. Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitis. J Immunol. 2007 Dec 15; 179(12):8509-18. PMID: 18056398.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  24. Barthel SR, Gavino JD, Descheny L, Dimitroff CJ. Targeting selectins and selectin ligands in inflammation and cancer. Expert Opin Ther Targets. 2007 Nov; 11(11):1473-91. PMID: 18028011.
    Citations: 88     Fields:    Translation:HumansAnimals
  25. Yamanaka K, Dimitroff CJ, Fuhlbrigge RC, Kakeda M, Kurokawa I, Mizutani H, Kupper TS. Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression. J Allergy Clin Immunol. 2008 Jan; 121(1):148-157.e3. PMID: 17910894.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  26. Alcaide P, King SL, Dimitroff CJ, Lim YC, Fuhlbrigge RC, Luscinskas FW. The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo. J Invest Dermatol. 2007 Aug; 127(8):1964-72. PMID: 17392823.
    Citations: 28     Fields:    Translation:AnimalsCells
  27. Gainers ME, Descheny L, Dimitroff CJ. . A Novel Adhesion Molecule Plays a Critical Role in T Cell Migration to Inflamed Skin. STAR Award Lecture. 2007.
  28. Gainers ME, Descheny L, Dimitroff CJ. . Molecular analysis of skin-homing receptors on natural killer cells associated with allergic contact dermatitis. J. Invest Derm. 2007; In press.
  29. Gainers ME, Dimitroff CJ. . Cytokine Aberrations Associated with Cutaneous Diseases in Persons of Color. McGraw-Hill Publishing Group. 2007; In press.
  30. Descheny L, Gainers ME, Walcheck B, Dimitroff CJ. Ameliorating skin-homing receptors on malignant T cells with a fluorosugar analog of N-acetylglucosamine: P-selectin ligand is a more sensitive target than E-selectin ligand. J Invest Dermatol. 2006 Sep; 126(9):2065-73. PMID: 16691194.
    Citations: 14     Fields:    Translation:HumansCells
  31. Yamanaka K, Dimitroff CJ, Mizutani H, Kupper TS. Vitamin A and D derivatives block cutaneous lymphocyte-associated antigen expression on human T cells via selective glycosyltransferase inhibition. J. Invest Derm. 2006; 126:123.
  32. Gainers ME, Descheny L, Dimitroff CJ. . Identifying a novel skin-homing receptor on inflammatory lymphocytes. J. Invest Derm. 2006; 126:121.
  33. Dimitroff CJ, Descheny L, Trujillo N, Kim R, Nguyen V, Huang W, Pienta KJ, Kutok JL, Rubin MA. Identification of leukocyte E-selectin ligands, P-selectin glycoprotein ligand-1 and E-selectin ligand-1, on human metastatic prostate tumor cells. Cancer Res. 2005 Jul 01; 65(13):5750-60. PMID: 15994950.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  34. Descheny L, Dimitroff, CJ. Downregulation of Cutaneous Lymphocyte-Associated Antigen and E-selectin Ligand Activity on Malignant Skin Homing T-cells with the Fluorosugar, 4-Fluorinated-N-acetylglucosamine. J. Invest. Derm. 2005; 124:A32.
  35. Dimitroff CJ. . Sharing of the Same Vascular Addressins for Osteotropic Behavior on Hematopoietic Progenitor Cells and Cancer. BoneKEy-Osteovision. 2005; 2(10):16-19.
  36. Dimitroff CJ, Lechpammer M, Long-Woodward D, Kutok JL. Rolling of human bone-metastatic prostate tumor cells on human bone marrow endothelium under shear flow is mediated by E-selectin. Cancer Res. 2004 Aug 01; 64(15):5261-9. PMID: 15289332.
    Citations: 45     Fields:    Translation:HumansCells
  37. Dimitroff CJ. . Expression of cutaneous lymphocyte-associated antigen on human bone-metastatic prostate tumor cells. J. Invest. Derm. 2004; 122:A30.
  38. Dimitroff CJ. Leukocyte E-selectin ligand, PSGL-1, is Expressed on Human Bone-Metastatic Prostate Tumor Cells and Mediates Rolling Interactions on Human Bone Marrow Endothelium. Clin. Exp. Met. 2004; 21(7):599-622.
  39. Dimitroff CJ, Kupper TS, Sackstein R. Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen. J Clin Invest. 2003 Oct; 112(7):1008-18. PMID: 14523038.
    Citations: 25     Fields:    Translation:AnimalsCells
  40. Dimitroff CJ, Liu L, Kupper TS, Sackstein R. . Preventing the Effector Phase of Allergic Contact Dermatitis with a Metabolic Inhibitor of CLA Synthesis. J. Invest. Derm. 2003; 121(1):1211.
  41. Cain DW, Schreiber TH, Dimitroff CJ, Chung C, Otero J, Sackstein R. . CD44/HCELL is an E- and L-selectin ligand on murine hematopoietic progenitor cells. Blood. 2003; 102(11):180b.
  42. Schreiber TH, Cain DW, Dimitroff CJ, Sackstein R. . G-CSF mobilization radically up-regulates á-1, 3 fucosyltransferases-4 and -7 generating high avidity E-selectin ligands on circulating nucleated cells. Blood. 2003; 102(11):115a.
  43. Dimitroff CJ, Bernacki RJ, Sackstein R. Glycosylation-dependent inhibition of cutaneous lymphocyte-associated antigen expression: implications in modulating lymphocyte migration to skin. Blood. 2003 Jan 15; 101(2):602-10. PMID: 12393521.
    Citations: 23     Fields:    Translation:HumansCells
  44. Fuhlbrigge RC, King SL, Dimitroff CJ, Kupper TS, Sackstein R. Direct real-time observation of E- and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on Western blots. J Immunol. 2002 Jun 01; 168(11):5645-51. PMID: 12023362.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  45. Dimitroff CJ, Sackstein R. Functional Modulation of Cutaneous Lymphocyte-Associated Antigen on Skin-Homing Lymphocytes and Prevention of Allergic Contact Dermatitis with a Novel Fluorinated Analog of N-acetylglucosamine. . J. Invest. Derm. 2002; 119(1):343.
  46. Fuhlbrigge RC, King S, Dimitroff CJ, Kupper TS, Sackstein R. . Direct real-time observation of E-and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on western blots. J. Immunology. 2002; 168:5645-51.
  47. Sackstein R, Dimitroff CJ, Lee JY. . Expression of Selectin Ligands on Blasts from Acute Leukemias. Exp. Hematol. 2002.
  48. Dimitroff CJ, Lee JY, Schor KS, Sandmaier BM, Sackstein R. differential L-selectin binding activities of human hematopoietic cell L-selectin ligands, HCELL and PSGL-1. J Biol Chem. 2001 Dec 14; 276(50):47623-31. PMID: 11591704.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  49. Dimitroff CJ, Lee JY, Rafii S, Fuhlbrigge RC, Sackstein R. CD44 is a major E-selectin ligand on human hematopoietic progenitor cells. J Cell Biol. 2001 Jun 11; 153(6):1277-86. PMID: 11402070.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  50. Dimitroff CJ, Lee JY, Sackstein R. . CD44 is the primary L-selectin ligand on human leukemias. Proc. AACR. 2001; 42:298.
  51. Fuhlbrigge RC, King S, Dimitroff CJ, Sackstein R, Kupper TS. . Direct Observation of E-Selectin Mediated Rolling on Cutaneous Lymphocyte-Associated Antigen Using a Novel Blot Rolling Assay. Proc. J. Invest. Derm. 2001.
  52. Sackstein R, Dimitroff CJ, Lee JY, Fuhlbrigge RC, Parmar K, Mauch PM, Sandmaier B. . Homing and hematopoiesis: HCELL is a principal E- and L-selectin ligand of human hematopoietic stem cells. Proc. Blood. 2001.
  53. Dimitroff CJ, Lee JY, Fuhlbrigge RC, Sackstein R. A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cells. Proc Natl Acad Sci U S A. 2000 Dec 05; 97(25):13841-6. PMID: 11095749.
    Citations: 39     Fields:    Translation:HumansCells
  54. Sackstein R, Dimitroff CJ. A hematopoietic cell L-selectin ligand that is distinct from PSGL-1 and displays N-glycan-dependent binding activity. Blood. 2000 Oct 15; 96(8):2765-74. PMID: 11023510.
    Citations: 22     Fields:    Translation:HumansCells
  55. Dimitroff CJ, Sackstein, R. . Identification of novel proteins bearing cutaneous lymphocyte antigens on human leukemias. J. Invest. Derm. 2000; 114(4):831.
  56. Sackstein R, Dimitroff CJ, Fuhlbrigge RC. . A new method for identification of adhesive interactions under shear force conditions. Exp. Hematol. 2000; 28(7):35.
  57. Dimitroff CJ, Lee J, Fuhlbrigge RC, Sackstein R. . A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic progenitor cells. Proc. Natl. Acad. Sci. 2000; 97(25):13841-13846.
  58. Dimitroff CJ, Lee J, Sackstein R. . Identification and characterization of a novel cell adhesion phenotype on acute myelogenous leukemias. Proc. AACR. 2000; 41:571.
  59. Dimitroff CJ, Pera P, Dall'Olio F, Matta KL, Chandrasekaran EV, Lau JT, Bernacki RJ. Cell surface n-acetylneuraminic acid alpha2,3-galactoside-dependent intercellular adhesion of human colon cancer cells. Biochem Biophys Res Commun. 1999 Mar 24; 256(3):631-6. PMID: 10080950.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  60. Dimitroff CJ, Klohs W, Sharma A, Pera P, Driscoll D, Veith J, Steinkampf R, Schroeder M, Klutchko S, Sumlin A, Henderson B, Dougherty TJ, Bernacki RJ. Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy. Invest New Drugs. 1999; 17(2):121-35. PMID: 10638483.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  61. Dimitroff CJ, Dall’Olio F, Bernacki RJ, Lau JT. . Enhanced heterotypic human colon cancer cell adhesion related to cell surface á2,3 sialylation. Proc. AACR. 1999; 2976:450.
  62. Dimitroff CJ, Pera P, Dall’Olio F, Matta KL, Chandrasekaran EV, Lau JT, Bernacki RJ. Cell surface N-acetylneuraminic acid á2,3-galactoside-dependent intercellular adhesion of human colon cancer cells. Biochem. Biophys. Res. Comm. 1999; 256:631-636.
  63. Dimitroff CJ, Klohs W, Henderson B, Dougherty TJ, Bernacki RJ. Antitumor efficacy of PD166285 and PD173074, novel inhibitors of receptor tyrosine kinases, in combination with photodynamic therapy. VII Int. Con. Met. Res. Soc. 1998; 41.
  64. Dimitroff CJ, Sharma A, Bernacki RJ. Cancer metastasis: a search for therapeutic inhibition. Cancer Invest. 1998; 16(4):279-90. PMID: 9589037.
    Citations: 7     Fields:    Translation:HumansAnimals
  65. Dimitroff CJ, Klohs W, Sharma A, Oh L, Pera P, Driscoll D, An C, Veith J, Schroeder M, Klutchko S, Bernacki R J. . Evaluation of the effects of PD166285 and PD173074 on in vitro and in vivo angiogenesis. Proc. AACR. 1998; 653:62.
  66. Woynarowska B, Dimitroff CJ, Sharma M, Matta KL, Bernacki RJ. Inhibition of human HT-29 colon carcinoma cell adhesion by a 4-fluoro-glucosamine analogue. Glycoconj J. 1996 Aug; 13(4):663-74. PMID: 8872124.
    Citations: 10     Fields:    Translation:HumansCells
  67. Woynarowska B, Dimitroff CJ, Skrincosky D, Sharma M, Matta K, Bernacki RJ. . The effect of a 4-fluoro-glucosamine analog on the adhesion of human colon carcinoma HT-29 cells. Glycoconjugate J. 1996; 13(4):663-674.
  68. Bernacki RJ, Woynarowska B, Dimitroff CJ, Sharma M, Matta KL. . Inhibition of human colon carcinoma cell adhesion and homotypic aggregation by a 4-fluoro-glucosamine analog. Glycoconjugate J. 1995; 12(4):396.
  69. Dimitroff CJ, Woynarowska B, Mazurchuk R, Sharma M, Matta KL, Bernacki RJ. Development of a colon tumor metastasis model in nude mice to assess the anti-metastatic activity of sugar analogs using magnetic resonance imaging. Glycoconjugate J. 1995; 12(4):397.
  70. Woynarowska B, Skrincosky D, Dimitroff CJ, Haag A, Sharma M, Matta K, Bernacki RJ . Modulation of tumor cell surface glycoconjugates by fluorinated N-acetylglucosamine analogs. Proc. AACR. 1994; 35:20.
  71. Bernacki RJ, Dimitroff CJ, Sharma M, Matta K. Woynarowska B. Fluorinated N-acetyl-glucosamine Analogs: Modulators of tumor cell surface glycoconjugates and cellular adhesion. Clin. Exp. Met. 1994; 12(5):41.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.