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profilePeter H. Lapchak, Ph.D.

TitleLecturer on Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Center
Medicine/Rheumatology, CLS-928
330 Brookline Ave
Boston MA 02215
Phone617/735-4167
Fax617/735-4170
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Collapse Biography 
Collapse awards and honors
1985 - 1986Fonds pour la Formation de Chercheurs et l’Aide Recherche (FCAR)
1989 - 1992Canadian Diabetes Association (Edmonton Branch), J. B. Collip Diabetes Studentship
1989 - 1989Juvenile Diabetes Foundation (US) Summer Student Award
1993 - 1993Mary Louise Imrie Student Travel Award, Faculty of Graduate Studies and Research, U. Alberta
1995 - 1995Society for Leukocyte Biology Travel Award
1997 - 1998Joseph E. Murrray Award, National Kidney Foundation Massachusetts and Rhode Island Affiliate
1998 - 2000American Heart Association-Massachusetts Affiliate Fellowship
2002 - 2003Pediatric Renal Research Award, National Kidney Foundation of Massachusetts, RI, NH, VT Affiliate
2005 - 2006Surgical Infection Society (SIS) Junior Faculty Research Fellowship Award
2006 - 2007Surgical Infection Society (SIS) Junior Faculty Research Fellowship Award Competitive Renewal
2009 - 2011Department of Defense Research Grant
2009 - 2011Department of Defense Research Grant

Collapse Overview 
Collapse overview
My research interests over the last 8 years has been to decipher the role of platelets in immune responses and inflammation using animal models of local and systemic trauma, namely ischemia-reperfusion and thermal injury. Platelets have many features in common with classical immune cells such as monocytes and lymphocytes although they are devoid of a nucleus. They are capable of secreting cytokines and express cell surface molecules that are common on immune cells. Although platelets are typically pro-inflammatory in nature, they may also be protective to the host after severe trauma by dampening the pro-inflammatory cascade. Thus, platelets may modulate the host response to systemic injury such as that observed in burn injury. In contrast, platelets may be detrimental to the host after severe local trauma such as that observed in ischemia-reperfusion injury. My overall goals are 1) to identify the differences in platelet responses and platelet-mediated immune responses after systemic or local trauma, 2) to determine the signaling pathways important in platelet activation in response to these different modes of injury, 3) identify differences in platelet subsets and their origins, and 4) understand the role of platelets in systemic and organ-specific autoimmune disease.

Platelets may associate with soluble factors such as those of the complement system and with immunoglobulins. Another aspect of my research involves identifying specific factors that associate with platelets and determine if, together they mediate tissue injury and organ damage. Ultimately, developing diagnostic tools to identify inappropriate platelet activation and pharmacotherapeutic and biotherapeutic agents to dampen or prevent tissue injury are realistic goals.


Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bialas AR, Presumey J, Das A, van der Poel CE, Lapchak PH, Mesin L, Victora G, Tsokos GC, Mawrin C, Herbst R, Carroll MC. Microglia-dependent synapse loss in type I interferon-mediated lupus. Nature. 2017 Jun 22; 546(7659):539-543. PMID: 28614301.
    View in: PubMed
  2. Satyam A, Kannan L, Matsumoto N, Geha M, Lapchak PH, Bosse R, Shi GP, Dalle Lucca JJ, Tsokos MG, Tsokos GC. Intracellular Activation of Complement 3 Is Responsible for Intestinal Tissue Damage during Mesenteric Ischemia. J Immunol. 2017 Jan 15; 198(2):788-797. PMID: 27913632.
    View in: PubMed
  3. Lapchak PH, Ioannou A, Rani P, Lieberman LA, Yoshiya K, Kannan L, Dalle Lucca JJ, Kowalska MA, Tsokos GC. The role of platelet factor 4 in local and remote tissue damage in a mouse model of mesenteric ischemia/reperfusion injury. PLoS One. 2012; 7(7):e39934. PMID: 22792197; PMCID: PMC3391230.
  4. Lapchak PH, Kannan L, Rani P, Pamuk ON, Ioannou A, Dalle Lucca JJ, Pine P, Tsokos GC. Inhibition of Syk activity by R788 in platelets prevents remote lung tissue damage after mesenteric ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15; 302(12):G1416-22. PMID: 22492694.
    View in: PubMed
  5. Lapchak PH, Ioannou A, Kannan L, Rani P, Dalle Lucca JJ, Tsokos GC. Platelet-associated CD40/CD154 mediates remote tissue damage after mesenteric ischemia/reperfusion injury. PLoS One. 2012; 7(2):e32260. PMID: 22384195; PMCID: PMC3288090.
  6. Lapchak PH, Kannan L, Ioannou A, Rani P, Karian P, Dalle Lucca JJ, Tsokos GC. Platelets orchestrate remote tissue damage after mesenteric ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol. 2012 Apr 15; 302(8):G888-97. PMID: 22301111.
    View in: PubMed
  7. Yoshiya K, Lapchak PH, Thai TH, Kannan L, Rani P, Dalle Lucca JJ, Tsokos GC. Depletion of gut commensal bacteria attenuates intestinal ischemia/reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2011 Dec; 301(6):G1020-30. PMID: 21903760.
    View in: PubMed
  8. Pamuk ON, Lapchak PH, Rani P, Pine P, Dalle Lucca JJ, Tsokos GC. Spleen tyrosine kinase inhibition prevents tissue damage after ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol. 2010 Aug; 299(2):G391-9. PMID: 20522642; PMCID: PMC3774480.
  9. Fujimi S, Lapchak PH, Zang Y, MacConmara MP, Maung AA, Delisle AJ, Mannick JA, Lederer JA. Murine dendritic cell antigen-presenting cell function is not altered by burn injury. J Leukoc Biol. 2009 May; 85(5):862-70. PMID: 19228816; PMCID: PMC2669406.
  10. Shi T, Moulton VR, Lapchak PH, Deng GM, Dalle Lucca JJ, Tsokos GC. Ischemia-mediated aggregation of the actin cytoskeleton is one of the major initial events resulting in ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2009 Feb; 296(2):G339-47. PMID: 19095765.
    View in: PubMed
  11. MacConmara MP, Maung AA, Fujimi S, McKenna AM, Delisle A, Lapchak PH, Rogers S, Lederer JA, Mannick JA. Increased CD4+ CD25+ T regulatory cell activity in trauma patients depresses protective Th1 immunity. Ann Surg. 2006 Oct; 244(4):514-23. PMID: 16998360; PMCID: PMC1856576.
  12. Fujimi S, MacConmara MP, Maung AA, Zang Y, Mannick JA, Lederer JA, Lapchak PH. Platelet depletion in mice increases mortality after thermal injury. Blood. 2006 Jun 01; 107(11):4399-406. PMID: 16467203; PMCID: PMC1895793.
  13. Flaxenburg JA, Melter M, Lapchak PH, Briscoe DM, Pal S. The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase. J Immunol. 2004 Jun 15; 172(12):7503-9. PMID: 15187129.
    View in: PubMed
  14. Lapchak PH, Melter M, Pal S, Flaxenburg JA, Geehan C, Frank MH, Mukhopadhyay D, Briscoe DM. CD40-induced transcriptional activation of vascular endothelial growth factor involves a 68-bp region of the promoter containing a CpG island. Am J Physiol Renal Physiol. 2004 Sep; 287(3):F512-20. PMID: 15140761.
    View in: PubMed
  15. Frank NY, Pendse SS, Lapchak PH, Margaryan A, Shlain D, Doeing C, Sayegh MH, Frank MH. Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. J Biol Chem. 2003 Nov 21; 278(47):47156-65. PMID: 12960149.
    View in: PubMed
  16. Lapchak PH, Briscoe DM. Hyporesponsiveness in pediatric recipients. Pediatr Transplant. 2002 Feb; 6(1):8-11. PMID: 11906635.
    View in: PubMed
  17. Pellegrini JD, Puyana JC, Lapchak PH, Kodys K, Miller-Graziano CL. A membrane TNF-alpha/TNFR ratio correlates to MODS score and mortality. Shock. 1996 Dec; 6(6):389-96. PMID: 8961387.
    View in: PubMed
  18. Pelligrini M.D., J., J.C. Puyana M.D., A. De Ph.D., G. Fudem M.D., K. Kodys B.A., P. Lapchak Ph.D., and C. Miller Ph.D. A Trauma Induced T Cell Defect is Associated with Deregulated Monokine Production and Is Truly Predictive of Poor Clinical Outcome. Surgical Forum. 1996; XLVII:64-66.
  19. Rabinovitch A, Suarez-Pinzon WL, Lapchak PH, Meager A, Power RF. Tumor necrosis factor mediates the protective effect of Freund's adjuvant against autoimmune diabetes in BB rats. J Autoimmun. 1995 Jun; 8(3):357-66. PMID: 7575997.
    View in: PubMed
  20. Garner R, Helgason CD, Atkinson EA, Pinkoski MJ, Ostergaard HL, Sorensen O, Fu A, Lapchak PH, Rabinovitch A, McElhaney JE, et al. Characterization of a granule-independent lytic mechanism used by CTL hybridomas. J Immunol. 1994 Dec 15; 153(12):5413-21. PMID: 7527440.
    View in: PubMed
  21. Wride MA, Lapchak PH, Sanders EJ. Distribution of TNF alpha-like proteins correlates with some regions of programmed cell death in the chick embryo. Int J Dev Biol. 1994 Dec; 38(4):673-82. PMID: 7779688.
    View in: PubMed
  22. Lapchak PH, Guilbert LJ, Rabinovitch A. Tumor necrosis factor production is deficient in diabetes-prone BB rats and can be corrected by complete Freund's adjuvant: a possible immunoregulatory role of tumor necrosis factor in the prevention of diabetes. Clin Immunol Immunopathol. 1992 Nov; 65(2):129-34. PMID: 1395129.
    View in: PubMed
  23. Issa-Chergui B, Goldner-Sauvé A, Colle E, Prud'homme GJ, Lapchak PH, van der Meide PH, Seemayer TA. Class I and II major histocompatibility complex gene product expression by a rat insulinoma cell line in vitro following exposure to gamma interferon. Diabetologia. 1988 Sep; 31(9):675-80. PMID: 2853088.
    View in: PubMed
  24. Prud'homme GJ, Lapchak PH, Parfrey NA, Colle E, Guttmann RD. Autoimmunity-prone BB rats lack functional cytotoxic T cells. Cell Immunol. 1988 Jun; 114(1):198-208. PMID: 3131022.
    View in: PubMed
  25. Herrington MB, Kohli A, Lapchak PH. Suppression by thymidine-requiring mutants of Escherichia coli K-12. J Bacteriol. 1984 Jan; 157(1):126-9. PMID: 6360992; PMCID: PMC215140.
  26. Herrington MB, Lapchak PH, Kohli A. Suppression by an Escherichia coli mutant under thymine-limiting conditions. Mutat Res. 1983 Feb; 119(2):109-11. PMID: 6338364.
    View in: PubMed
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