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Jonathan Lipton, M.D., Ph.D.

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Biography
Albert Einstein College of Medicine, New YorkMD, PhDMolecular Genetics
Brown University, Providence RIBAClassics
CHAM, New YorkInternshipPediatrics
Boston Children's Hospital, Boston MAResidencyChild Neurology
Boston Children's Hospital/BIDMC, Boston MAFellowshipSleep Medicine
Boston Children's Hospital/HMS, Boston MAPost-docNeurobiology
2016
Young Investigator Award

Overview

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL151368 (LIPTON, JONATHAN OREN) May 1, 2020 - Apr 30, 2024
    NIH/NHLBI
    Investigating Circadian Mechanisms of Cellular Resilience: Rhythmic Condensates, Disorder, and Stress
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Behne R, Teinert J, Wimmer M, D'Amore A, Davies AK, Scarrott JM, Eberhardt K, Brechmann B, Chen IP, Buttermore ED, Barrett L, Dwyer S, Chen T, Hirst J, Wiesener A, Segal D, Martinuzzi A, Duarte ST, Bennett JT, Bourinaris T, Houlden H, Roubertie A, Santorelli FM, Robinson M, Azzouz M, Lipton JO, Borner GHH, Sahin M, Ebrahimi-Fakhari D. Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein trafficking. Hum Mol Genet. 2020 01 15; 29(2):320-334. PMID: 31915823.
    Citations:    
  2. Barone I, Hawks-Mayer H, Lipton JO. Mechanisms of sleep and circadian ontogeny through the lens of neurodevelopmental disorders. Neurobiol Learn Mem. 2019 04; 160:160-172. PMID: 30668981.
    Citations:    Fields:    
  3. Archer TC, Ehrenberger T, Mundt F, Gold MP, Krug K, Mah CK, Mahoney EL, Daniel CJ, LeNail A, Ramamoorthy D, Mertins P, Mani DR, Zhang H, Gillette MA, Clauser K, Noble M, Tang LC, Pierre-François J, Silterra J, Jensen J, Tamayo P, Korshunov A, Pfister SM, Kool M, Northcott PA, Sears RC, Lipton JO, Carr SA, Mesirov JP, Pomeroy SL, Fraenkel E. Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups. Cancer Cell. 2018 09 10; 34(3):396-410.e8. PMID: 30205044.
    Citations:    Fields:    
  4. Kelly E, Schaeffer SM, Dhamne SC, Lipton JO, Lindemann L, Honer M, Jaeschke G, Super CE, Lammers SH, Modi ME, Silverman JL, Dreier JR, Kwiatkowski DJ, Rotenberg A, Sahin M. mGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex. Neuropsychopharmacology. 2018 05; 43(6):1457-1465. PMID: 29206810.
    Citations:    Fields:    
  5. Lipton JO, Boyle LM, Yuan ED, Hochstrasser KJ, Chifamba FF, Nathan A, Tsai PT, Davis F, Sahin M. Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy. Cell Rep. 2017 07 25; 20(4):868-880. PMID: 28746872.
    Citations: 6     Fields:    Translation:AnimalsCells
  6. Scammell TE, Arrigoni E, Lipton JO. Neural Circuitry of Wakefulness and Sleep. Neuron. 2017 Feb 22; 93(4):747-765. PMID: 28231463.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  7. Ebrahimi-Fakhari D, Saffari A, Wahlster L, DiNardo A, Turner D, Lewis TL, Conrad C, Rothberg JM, Lipton JO, Kölker S, Hoffmann GF, Han MJ, Polleux F, Sahin M. Impaired Mitochondrial Dynamics And Mitophagy In Neuronal Models Of Tuberous Sclerosis Complex. Cell Rep. 2016 11 15; 17(8):2162. PMID: 27851977.
    Citations: 3     Fields:    
  8. Ebrahimi-Fakhari D, Saffari A, Wahlster L, Di Nardo A, Turner D, Lewis TL, Conrad C, Rothberg JM, Lipton JO, Kölker S, Hoffmann GF, Han MJ, Polleux F, Sahin M. Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex. Cell Rep. 2016 10 18; 17(4):1053-1070. PMID: 27760312.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  9. Sun Y, Lipton JO, Boyle LM, Madsen JR, Goldenberg MC, Pascual-Leone A, Sahin M, Rotenberg A. Direct current stimulation induces mGluR5-dependent neocortical plasticity. Ann Neurol. 2016 08; 80(2):233-46. PMID: 27315032.
    Citations: 6     Fields:    Translation:HumansAnimals
  10. Lipton JO, Yuan ED, Boyle LM, Ebrahimi-Fakhari D, Kwiatkowski E, Nathan A, Güttler T, Davis F, Asara JM, Sahin M. The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation. Cell. 2015 May 21; 161(5):1138-1151. PMID: 25981667.
    Citations: 51     Fields:    Translation:AnimalsCells
  11. Lipton JO, Sahin M. The neurology of mTOR. Neuron. 2014 Oct 22; 84(2):275-91. PMID: 25374355.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  12. Olson H, Shen Y, Avallone J, Sheidley BR, Pinsky R, Bergin AM, Berry GT, Duffy FH, Eksioglu Y, Harris DJ, Hisama FM, Ho E, Irons M, Jacobsen CM, James P, Kothare S, Khwaja O, Lipton J, Loddenkemper T, Markowitz J, Maski K, Megerian JT, Neilan E, Raffalli PC, Robbins M, Roberts A, Roe E, Rollins C, Sahin M, Sarco D, Schonwald A, Smith SE, Soul J, Stoler JM, Takeoka M, Tan WH, Torres AR, Tsai P, Urion DK, Weissman L, Wolff R, Wu BL, Miller DT, Poduri A. Copy number variation plays an important role in clinical epilepsy. Ann Neurol. 2014 Jun; 75(6):943-58. PMID: 24811917.
    Citations: 33     Fields:    Translation:Humans
  13. Lipton J, Sahin M. Fragile X syndrome therapeutics: translation, meet translational medicine. Neuron. 2013 Jan 23; 77(2):212-3. PMID: 23352156.
    Citations: 3     Fields:    
  14. Lipton J, Rivkin MJ. 16p11.2-related paroxysmal kinesigenic dyskinesia and dopa-responsive parkinsonism in a child. Neurology. 2009 Aug 11; 73(6):479-80. PMID: 19667324.
    Citations: 8     Fields:    Translation:HumansCells
  15. Lipton J, Megerian JT, Kothare SV, Cho YJ, Shanahan T, Chart H, Ferber R, Adler-Golden L, Cohen LE, Czeisler CA, Pomeroy SL. Melatonin deficiency and disrupted circadian rhythms in pediatric survivors of craniopharyngioma. Neurology. 2009 Jul 28; 73(4):323-5. PMID: 19636054.
    Citations: 9     Fields:    Translation:Humans
  16. Lipton J, Becker RE, Kothare SV. Insomnia of childhood. Curr Opin Pediatr. 2008 Dec; 20(6):641-9. PMID: 19005332.
    Citations: 2     Fields:    Translation:Humans
  17. Lipton J, Joffe S, Ullrich NJ. CNS relapse of acute myelogenous leukemia masquerading as pseudotumor cerebri. Pediatr Neurol. 2008 Nov; 39(5):355-7. PMID: 18940560.
    Citations: 4     Fields:    Translation:Humans
  18. Jonathan Lipton and Michael J. Rivkin. Kawasaki disease: cerebrovascular and neurologic complication. Uncommon Causes of Stroke. 2008.
  19. Lipton, J. and Rivkin, M.J. Kawasaki disease: cerebrovascular and neurologic complications. Uncommon Causes of Stroke (editor LR Caplan). 2008.
  20. Jonathan O. Lipton, Yoon-Jae Cho, Jonathan T. Megerian, Theresa Shanahan, Laurie Cohen, Richard Ferber, Charles Czeisler, Sanjeev V. Kothare, Scott L. Pomeroy. Disruption of Circadian Melatonin Secretion in Pediatric Craniopharyngioma Survivors with Hypersomnolence. Sleep (Abstract). 2008.
  21. Lipton, J. . Mating worms and the cystic kidney: C. elegans as a model for renal disease. Pediatric Nephrology. 2005; 20:1531-36.
  22. Lipton, J. , Kleemann, G., Ghosh, R., Lints, R., Emmons, S.W. . Mate searching in Caenorhabditis elegans: a genetic model for sex drive in a simple in vertebrate. Journal of Neuroscience. 2004; 24:7427-34.
  23. Jonathan Oren Lipton. Genetics of Sexually Motivated Behavior in Caenorhabditis elegans. 2003.
  24. Emmons, S.W. and Lipton, J. The genetic basis of male mating behavior. Journal of Neurobiology. 2003; 54:93-110.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.