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profileGalit Alter, Ph.D.

TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
AIDS Research, 149-5
149 13th Street
Charlestown MA 02129
Fax617/726-5411
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R33AI110165     (ALTER, GALIT)Dec 1, 2015 - Jan 31, 2019
NIH/NIAID
Killing the Reservoir with Antibodies
Role: Principal Investigator

R21AI110165     (ALTER, GALIT)Dec 1, 2013 - Nov 30, 2015
NIH/NIAID
Killing the Reservoir with Antibodies
Role: Principal Investigator

R01AI102660     (ALTER, GALIT)Jul 1, 2012 - Jun 30, 2016
NIH/NIAID
Tuning Fc-effector functions of HIV-specific antibodies
Role: Principal Investigator

R56AI095078     (ALTER, GALIT)Sep 20, 2011 - Aug 31, 2012
NIH/NIAID
The Innate Immune Signals on B Cells that Induce ADCC Antibodies
Role: Principal Investigator

R01AI080289     (ALTER, GALIT)Jul 1, 2008 - Nov 30, 2019
NIH/NIAID
Cytolytic antibodies:Bridging the gap between the innate and adaptive immune resp
Role: Principal Investigator
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This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Ragon Institute Imaging Core, Microscopy (MGH) - Core services (4), Instruments (7) and Software (3)
Ragon Institute Imaging Core, Flow Cytometry (MGH) - Core services (4) and Instruments (8)

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bradley T, Pollara J, Santra S, Vandergrift N, Pittala S, Bailey-Kellogg C, Shen X, Parks R, Goodman D, Eaton A, Balachandran H, Mach LV, Saunders KO, Weiner JA, Scearce R, Sutherland LL, Phogat S, Tartaglia J, Reed SG, Hu SL, Theis JF, Pinter A, Montefiori DC, Kepler TB, Peachman KK, Rao M, Michael NL, Suscovich TJ, Alter G, Ackerman ME, Moody MA, Liao HX, Tomaras G, Ferrari G, Korber BT, Haynes BF. Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge. Nat Commun. 2017 Jun 08; 8:15711. PMID: 28593989.
    View in: PubMed
  2. Dugast AS, Arnold K, Lofano G, Moore S, Hoffner M, Simek M, Poignard P, Seaman M, Suscovich TJ, Pereyra F, Walker BD, Lauffenburger D, Kwon DS, Keele BF, Alter G. Virus-driven Inflammation Is Associated With the Development of bNAbs in Spontaneous Controllers of HIV. Clin Infect Dis. 2017 Apr 15; 64(8):1098-1104. PMID: 28158448.
    View in: PubMed
  3. Jennewein MF, Alter G. The Immunoregulatory Roles of Antibody Glycosylation. Trends Immunol. 2017 May; 38(5):358-372. PMID: 28385520.
    View in: PubMed
  4. Brown EP, Dowell KG, Boesch AW, Normandin E, Mahan AE, Chu T, Barouch DH, Bailey-Kellogg C, Alter G, Ackerman ME. Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles. J Immunol Methods. 2017 Apr; 443:33-44. PMID: 28163018.
    View in: PubMed
  5. Ackerman ME, Barouch DH, Alter G. Systems serology for evaluation of HIV vaccine trials. Immunol Rev. 2017 Jan; 275(1):262-270. PMID: 28133810.
    View in: PubMed
  6. Weiss ER, Alter G, Ogembo JG, Henderson JL, Tabak B, Bakis Y, Somasundaran M, Garber M, Selin L, Luzuriaga K. High Epstein-Barr Virus Load and Genomic Diversity Are Associated with Generation of gp350-Specific Neutralizing Antibodies following Acute Infectious Mononucleosis. J Virol. 2017 Jan 01; 91(1). PMID: 27733645.
    View in: PubMed
  7. Borducchi EN, Cabral C, Stephenson KE, Liu J, Abbink P, Ng'ang'a D, Nkolola JP, Brinkman AL, Peter L, Lee BC, Jimenez J, Jetton D, Mondesir J, Mojta S, Chandrashekar A, Molloy K, Alter G, Gerold JM, Hill AL, Lewis MG, Pau MG, Schuitemaker H, Hesselgesser J, Geleziunas R, Kim JH, Robb ML, Michael NL, Barouch DH. Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys. Nature. 2016 12 08; 540(7632):284-287. PMID: 27841870.
    View in: PubMed
  8. Huang Y, Ferrari G, Alter G, Forthal DN, Kappes JC, Lewis GK, Love JC, Borate B, Harris L, Greene K, Gao H, Phan TB, Landucci G, Goods BA, Dowell KG, Cheng HD, Bailey-Kellogg C, Montefiori DC, Ackerman ME. Diversity of Antiviral IgG Effector Activities Observed in HIV-Infected and Vaccinated Subjects. J Immunol. 2016 Dec 15; 197(12):4603-4612. PMID: 27913647.
    View in: PubMed
  9. Gunn BM, Alter G. Modulating Antibody Functionality in Infectious Disease and Vaccination. Trends Mol Med. 2016 Nov; 22(11):969-982. PMID: 27756530.
    View in: PubMed
  10. Vaccari M, Gordon SN, Fourati S, Schifanella L, Liyanage NP, Cameron M, Keele BF, Shen X, Tomaras GD, Billings E, Rao M, Chung AW, Dowell KG, Bailey-Kellogg C, Brown EP, Ackerman ME, Vargas-Inchaustegui DA, Whitney S, Doster MN, Binello N, Pegu P, Montefiori DC, Foulds K, Quinn DS, Donaldson M, Liang F, Loré K, Roederer M, Koup RA, McDermott A, Ma ZM, Miller CJ, Phan TB, Forthal DN, Blackburn M, Caccuri F, Bissa M, Ferrari G, Kalyanaraman V, Ferrari MG, Thompson D, Robert-Guroff M, Ratto-Kim S, Kim JH, Michael NL, Phogat S, Barnett SW, Tartaglia J, Venzon D, Stablein DM, Alter G, Sekaly RP, Franchini G. Corrigendum: Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition. Nat Med. 2016 Oct 06; 22(10):1192. PMID: 27711066.
    View in: PubMed
  11. Lu LL, Chung AW, Rosebrock TR, Ghebremichael M, Yu WH, Grace PS, Schoen MK, Tafesse F, Martin C, Leung V, Mahan AE, Sips M, Kumar MP, Tedesco J, Robinson H, Tkachenko E, Draghi M, Freedberg KJ, Streeck H, Suscovich TJ, Lauffenburger DA, Restrepo BI, Day C, Fortune SM, Alter G. A Functional Role for Antibodies in Tuberculosis. Cell. 2016 Oct 06; 167(2):433-443.e14. PMID: 27667685.
    View in: PubMed
  12. Chan YN, Boesch AW, Osei-Owusu NY, Emileh A, Crowley AR, Cocklin SL, Finstad SL, Linde CH, Howell RA, Zentner I, Cocklin S, Miles AR, Eckman JW, Alter G, Schmitz JE, Ackerman ME. IgG Binding Characteristics of Rhesus Macaque Fc?R. J Immunol. 2016 Oct 01; 197(7):2936-47. PMID: 27559046; PMCID: PMC5026948 [Available on 10/01/17].
  13. Sips M, Liu Q, Draghi M, Ghebremichael M, Berger CT, Suscovich TJ, Sun Y, Walker BD, Carrington M, Altfeld M, Brouckaert P, De Jager PL, Alter G. HLA-C levels impact natural killer cell subset distribution and function. Hum Immunol. 2016 Dec; 77(12):1147-1153. PMID: 27521484.
    View in: PubMed
  14. Abbink P, Larocca RA, De La Barrera RA, Bricault CA, Moseley ET, Boyd M, Kirilova M, Li Z, Ng'ang'a D, Nanayakkara O, Nityanandam R, Mercado NB, Borducchi EN, Agarwal A, Brinkman AL, Cabral C, Chandrashekar A, Giglio PB, Jetton D, Jimenez J, Lee BC, Mojta S, Molloy K, Shetty M, Neubauer GH, Stephenson KE, Peron JP, Zanotto PM, Misamore J, Finneyfrock B, Lewis MG, Alter G, Modjarrad K, Jarman RG, Eckels KH, Michael NL, Thomas SJ, Barouch DH. Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys. Science. 2016 09 09; 353(6304):1129-32. PMID: 27492477.
    View in: PubMed
  15. Garcia-Beltran WF, Hölzemer A, Martrus G, Chung AW, Pacheco Y, Simoneau CR, Rucevic M, Lamothe-Molina PA, Pertel T, Kim TE, Dugan H, Alter G, Dechanet-Merville J, Jost S, Carrington M, Altfeld M. Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1. Nat Immunol. 2016 Sep; 17(9):1067-74. PMID: 27455421; PMCID: PMC4992421 [Available on 01/25/17].
  16. Barnett BE, Staupe RP, Odorizzi PM, Palko O, Tomov VT, Mahan AE, Gunn B, Chen D, Paley MA, Alter G, Reiner SL, Lauer GM, Teijaro JR, Wherry EJ. Cutting Edge: B Cell-Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection. J Immunol. 2016 Aug 15; 197(4):1017-22. PMID: 27430722; PMCID: PMC4975981 [Available on 08/15/17].
  17. Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J. International AIDS Society global scientific strategy: towards an HIV cure 2016. Nat Med. 2016 Aug; 22(8):839-50. PMID: 27400264.
    View in: PubMed
  18. Julg B, Alter G. Broadly Neutralizing Antibodies: Magic Bullets against HIV? Immunity. 2016 Jun 21; 44(6):1253-4. PMID: 27332729.
    View in: PubMed
  19. Mahan AE, Jennewein MF, Suscovich T, Dionne K, Tedesco J, Chung AW, Streeck H, Pau M, Schuitemaker H, Francis D, Fast P, Laufer D, Walker BD, Baden L, Barouch DH, Alter G. Correction: Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination. PLoS Pathog. 2016 Jun; 12(6):e1005694. PMID: 27253391.
    View in: PubMed
  20. Vaccari M, Gordon SN, Fourati S, Schifanella L, Liyanage NP, Cameron M, Keele BF, Shen X, Tomaras GD, Billings E, Rao M, Chung AW, Dowell KG, Bailey-Kellogg C, Brown EP, Ackerman ME, Vargas-Inchaustegui DA, Whitney S, Doster MN, Binello N, Pegu P, Montefiori DC, Foulds K, Quinn DS, Donaldson M, Liang F, Loré K, Roederer M, Koup RA, McDermott A, Ma ZM, Miller CJ, Phan TB, Forthal DN, Blackburn M, Caccuri F, Bissa M, Ferrari G, Kalyanaraman V, Ferrari MG, Thompson D, Robert-Guroff M, Ratto-Kim S, Kim JH, Michael NL, Phogat S, Barnett SW, Tartaglia J, Venzon D, Stablein DM, Alter G, Sekaly RP, Franchini G. Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition. Nat Med. 2016 Jul; 22(7):762-70. PMID: 27239761.
    View in: PubMed
  21. Scully E, Alter G. NK Cells in HIV Disease. Curr HIV/AIDS Rep. 2016 Apr; 13(2):85-94. PMID: 27002078; PMCID: PMC4821863.
  22. Sarkar A, Hou HW, Mahan AE, Han J, Alter G. Multiplexed Affinity-Based Separation of Proteins and Cells Using Inertial Microfluidics. Sci Rep. 2016 Mar 30; 6:23589. PMID: 27026280; PMCID: PMC4812309.
  23. Mahan AE, Jennewein MF, Suscovich T, Dionne K, Tedesco J, Chung AW, Streeck H, Pau M, Schuitemaker H, Francis D, Fast P, Laufer D, Walker BD, Baden L, Barouch DH, Alter G. Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination. PLoS Pathog. 2016 Mar; 12(3):e1005456. PMID: 26982805; PMCID: PMC4794126.
  24. Gunn BM, Schneider JR, Shansab M, Bastian AR, Fahrbach KM, Smith AD, Mahan AE, Karim MM, Licht AF, Zvonar I, Tedesco J, Anderson MR, Chapel A, Suscovich TJ, Malaspina DC, Streeck H, Walker BD, Kim A, Lauer G, Altfeld M, Pillai S, Szleifer I, Kelleher NL, Kiser PF, Hope TJ, Alter G. Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16. Mucosal Immunol. 2016 Nov; 9(6):1549-1558. PMID: 26960182.
    View in: PubMed
  25. Licht A, Alter G. A Drug-Free Zone--Lymph Nodes as a Safe Haven for HIV. Cell Host Microbe. 2016 Mar 09; 19(3):275-6. PMID: 26962938.
    View in: PubMed
  26. Sips M, Krykbaeva M, Diefenbach TJ, Ghebremichael M, Bowman BA, Dugast AS, Boesch AW, Streeck H, Kwon DS, Ackerman ME, Suscovich TJ, Brouckaert P, Schacker TW, Alter G. Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies. Mucosal Immunol. 2016 Nov; 9(6):1584-1595. PMID: 26883728.
    View in: PubMed
  27. Schultz BT, Teigler JE, Pissani F, Oster AF, Kranias G, Alter G, Marovich M, Eller MA, Dittmer U, Robb ML, Kim JH, Michael NL, Bolton D, Streeck H. Circulating HIV-Specific Interleukin-21(+)CD4(+) T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions. Immunity. 2016 Jan 19; 44(1):167-78. PMID: 26795249.
    View in: PubMed
  28. Ackerman ME, Mikhailova A, Brown EP, Dowell KG, Walker BD, Bailey-Kellogg C, Suscovich TJ, Alter G. Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control. PLoS Pathog. 2016 Jan; 12(1):e1005315. PMID: 26745376; PMCID: PMC4706315.
  29. Hölzemer A, Thobakgale CF, Jimenez Cruz CA, Garcia-Beltran WF, Carlson JM, van Teijlingen NH, Mann JK, Jaggernath M, Kang SG, Körner C, Chung AW, Schafer JL, Evans DT, Alter G, Walker BD, Goulder PJ, Carrington M, Hartmann P, Pertel T, Zhou R, Ndung'u T, Altfeld M. Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa. PLoS Med. 2015 Nov; 12(11):e1001900; discussion e1001900. PMID: 26575988; PMCID: PMC4648589.
  30. Sadanand S, Suscovich TJ, Alter G. Broadly Neutralizing Antibodies Against HIV: New Insights to Inform Vaccine Design. Annu Rev Med. 2016; 67:185-200. PMID: 26565674.
    View in: PubMed
  31. Chung AW, Kumar MP, Arnold KB, Yu WH, Schoen MK, Dunphy LJ, Suscovich TJ, Frahm N, Linde C, Mahan AE, Hoffner M, Streeck H, Ackerman ME, McElrath MJ, Schuitemaker H, Pau MG, Baden LR, Kim JH, Michael NL, Barouch DH, Lauffenburger DA, Alter G. Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology. Cell. 2015 Nov 05; 163(4):988-98. PMID: 26544943.
    View in: PubMed
  32. Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJ, Klenerman P, Sharpe AH, Lauer GM, Haining WN. CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. PLoS Pathog. 2015 Oct; 11(10):e1005177. PMID: 26485519; PMCID: PMC4618999.
  33. Arnold KB, Szeto GL, Alter G, Irvine DJ, Lauffenburger DA. CD4+ T cell-dependent and CD4+ T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals. Sci Signal. 2015 Oct 20; 8(399):ra104. PMID: 26486173; PMCID: PMC4634873.
  34. Holtsberg FW, Shulenin S, Vu H, Howell KA, Patel SJ, Gunn B, Karim M, Lai JR, Frei JC, Nyakatura EK, Zeitlin L, Douglas R, Fusco ML, Froude JW, Saphire EO, Herbert AS, Wirchnianski AS, Lear-Rooney CM, Alter G, Dye JM, Glass PJ, Warfield KL, Aman MJ. Pan-ebolavirus and Pan-filovirus Mouse Monoclonal Antibodies: Protection against Ebola and Sudan Viruses. J Virol. 2015 Oct 14; 90(1):266-78. PMID: 26468533; PMCID: PMC4702560.
  35. Barouch DH, Alter G, Broge T, Linde C, Ackerman ME, Brown EP, Borducchi EN, Smith KM, Nkolola JP, Liu J, Shields J, Parenteau L, Whitney JB, Abbink P, Ng'ang'a DM, Seaman MS, Lavine CL, Perry JR, Li W, Colantonio AD, Lewis MG, Chen B, Wenschuh H, Reimer U, Piatak M, Lifson JD, Handley SA, Virgin HW, Koutsoukos M, Lorin C, Voss G, Weijtens M, Pau MG, Schuitemaker H. Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys. Science. 2015 Jul 17; 349(6245):320-4. PMID: 26138104; PMCID: PMC4653134.
  36. Brown EP, Normandin E, Osei-Owusu NY, Mahan AE, Chan YN, Lai JI, Vaccari M, Rao M, Franchini G, Alter G, Ackerman ME. Microscale purification of antigen-specific antibodies. J Immunol Methods. 2015 Oct; 425:27-36. PMID: 26078040; PMCID: PMC4604017 [Available on 10/01/16].
  37. Alter G, Sekaly RP. Beyond adjuvants: Antagonizing inflammation to enhance vaccine immunity. Vaccine. 2015 Jun 08; 33 Suppl 2:B55-9. PMID: 26022570.
    View in: PubMed
  38. Johnson S, Eller M, Teigler JE, Maloveste SM, Schultz BT, Soghoian DZ, Lu R, Oster AF, Chenine AL, Alter G, Dittmer U, Marovich M, Robb ML, Michael NL, Bolton D, Streeck H. Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in Control of HIV Viremia. J Virol. 2015 Aug; 89(15):7494-505. PMID: 25972560; PMCID: PMC4505667.
  39. Boesch AW, Alter G, Ackerman ME. Prospects for engineering HIV-specific antibodies for enhanced effector function and half-life. Curr Opin HIV AIDS. 2015 May; 10(3):160-9. PMID: 25700208; PMCID: PMC4419828.
  40. Alter G, Barouch DH. Natural evolution of broadly neutralizing antibodies. Cell. 2015 Apr 23; 161(3):427-8. PMID: 25910199; PMCID: PMC4426205.
  41. Sciaranghella G, Wang C, Hu H, Anastos K, Merhi Z, Nowicki M, Stanczyk FZ, Greenblatt RM, Cohen M, Golub ET, Watts DH, Alter G, Young MA, Tsibris AM. CCR5 Expression Levels in HIV-Uninfected Women Receiving Hormonal Contraception. J Infect Dis. 2015 Nov 01; 212(9):1397-401. PMID: 25895986; PMCID: PMC4601918 [Available on 11/01/16].
  42. Choi I, Chung AW, Suscovich TJ, Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kaewkungwal J, O'Connell RJ, Francis D, Robb ML, Michael NL, Kim JH, Alter G, Ackerman ME, Bailey-Kellogg C. Machine learning methods enable predictive modeling of antibody feature:function relationships in RV144 vaccinees. PLoS Comput Biol. 2015 Apr; 11(4):e1004185. PMID: 25874406; PMCID: PMC4395155.
  43. Chen J, Tibroni N, Sauter D, Galaski J, Miura T, Alter G, Mueller B, Haller C, Walker BD, Kirchhoff F, Brumme ZL, Ueno T, Fackler OT. Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma. PLoS One. 2015; 10(3):e0120434. PMID: 25793728; PMCID: PMC4368696.
  44. Kaczmarek Michaels K, Natarajan M, Euler Z, Alter G, Viglianti G, Henderson AJ. Blimp-1, an intrinsic factor that represses HIV-1 proviral transcription in memory CD4+ T cells. J Immunol. 2015 Apr 01; 194(7):3267-74. PMID: 25710909; PMCID: PMC4369419.
  45. Cohen KW, Dugast AS, Alter G, McElrath MJ, Stamatatos L. HIV-1 single-stranded RNA induces CXCL13 secretion in human monocytes via TLR7 activation and plasmacytoid dendritic cell-derived type I IFN. J Immunol. 2015 Mar 15; 194(6):2769-75. PMID: 25667414; PMCID: PMC4363079.
  46. Li JZ, Arnold KB, Lo J, Dugast AS, Plants J, Ribaudo HJ, Cesa K, Heisey A, Kuritzkes DR, Lauffenburger DA, Alter G, Landay A, Grinspoon S, Pereyra F. Differential levels of soluble inflammatory markers by human immunodeficiency virus controller status and demographics. Open Forum Infect Dis. 2015 Jan; 2(1):ofu117. PMID: 25884005; PMCID: PMC4396431.
  47. Suscovich TJ, Alter G. In situ production of therapeutic monoclonal antibodies. Expert Rev Vaccines. 2015 Feb; 14(2):205-19. PMID: 25578347.
    View in: PubMed
  48. Euler Z, Alter G. Exploring the potential of monoclonal antibody therapeutics for HIV-1 eradication. AIDS Res Hum Retroviruses. 2015 Jan; 31(1):13-24. PMID: 25385703; PMCID: PMC4287163.
  49. Mahan AE, Tedesco J, Dionne K, Baruah K, Cheng HD, De Jager PL, Barouch DH, Suscovich T, Ackerman M, Crispin M, Alter G. A method for high-throughput, sensitive analysis of IgG Fc and Fab glycosylation by capillary electrophoresis. J Immunol Methods. 2015 Feb; 417:34-44. PMID: 25523925.
    View in: PubMed
  50. Chung AW, Crispin M, Pritchard L, Robinson H, Gorny MK, Yu X, Bailey-Kellogg C, Ackerman ME, Scanlan C, Zolla-Pazner S, Alter G. Identification of antibody glycosylation structures that predict monoclonal antibody Fc-effector function. AIDS. 2014 Nov 13; 28(17):2523-30. PMID: 25160934; PMCID: PMC4429604.
  51. Mabuka JK, Dugast AS, Euler Z, Ramlakhan Y, Dong K, Walker BD, Ndung'u T, Alter G. Acute HIV-1 Subtype C Infection Is Associated with Rapid Increase of Tissue-like Memory and Decrease in Resting Memory B-cells. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A211. PMID: 25357593.
    View in: PubMed
  52. Kadasia K, Politch J, Schoen M, Chung A, Alter G, Anderson D. Local HIV-specific IgA Antibody Production in the Penile Urethra Mucosal Compartment. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A62-3. PMID: 25357902.
    View in: PubMed
  53. Ndlovu BG, Chung A, Maroa J, Walker BD, Alter G, Ndung'u T. Gp41 and p24 IgG Binding Antibody Titers Are Associated with HIV-1 Viral Control during Early HIV-1 Subtype C Infection. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A248. PMID: 25357698.
    View in: PubMed
  54. Mahan AE, Mattoo H, Dionne K, Tedesco J, Pillai S, Alter G. IgG Glycosylation Is Programmed and Remembered after Immunization with TLR Stimulating Adjuvants. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A65. PMID: 25357909.
    View in: PubMed
  55. Chung AW, Schoen MK, Robinson H, Licht A, Tkachenko E, Smith DM, Little SJ, Richman DD, Alter G. Polyfunctional Non-neutralizing Fc-antibody Responses in Acute HIV Infection Predict Spontaneous Viral Control. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A89. PMID: 25357969.
    View in: PubMed
  56. Schneider JR, Shansab M, Gunn B, Shen S, Lucas J, Smith A, Kelleher N, Tomaras G, Alter G, Veazey R, Hope T. Utilizing Mucin-tethered HIV IgG to Enhance HIV Vaccine Function. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A154. PMID: 25357430.
    View in: PubMed
  57. Sips M, Krykbaeva M, Bowman B, Diefenbach T, Kwon D, Brouckaert P, Alter G. Targeting Mucosal Fc-Fc Receptor Interactions as Vaccine Strategy against Mucosal HIV-transmission. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A63. PMID: 25357904.
    View in: PubMed
  58. Dugast AS, Arnold K, Hoffner M, Pereyra F, Seaman M, Walker B, Lauffenburger D, Alter G. An Inflammatory Profile that Predicts the Development of Neutralizing Antibody Breadth. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A35-6. PMID: 25357834.
    View in: PubMed
  59. Fourati S, Vaccari M, Gordon SN, Schifanella L, Cameron M, Keele BF, Shen X, Tomoras GD, Billings E, Rao M, Chung AW, Dowell K, Bailey-Kellogg C, Brown E, Ackerman ME, Liyanage NP, Vargas-Inchaistegui DA, Whitney S, Doster MN, Binello N, Pegu P, Montefiori DC, Foulds K, Quinn DS, Donaldson M, Liang F, Loré K, Roederer M, Koup RA, McDermott A, Ma ZM, Miller CJ, Phan TB, Forthal DN, Blackburn M, Caccuri F, Ferrari G, Thompson D, Robert-Guroff M, Ratto-Kim S, Kim JH, Michael NL, Phogat S, Barnett SW, Tartaglia J, Venzon D, Stablein DM, Alter G, Sekaly RP, Franchini G. Modulation of RAS Pathways as a Biomarker of Protection against HIV and as a Means to Improve Vaccine Efficacy. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A99. PMID: 25357995.
    View in: PubMed
  60. Cohen K, Altfeld M, Alter G, Stamatatos L. Early preservation of CXCR5+ PD-1+ helper T cells and B cell activation predict the breadth of neutralizing antibody responses in chronic HIV-1 infection. J Virol. 2014 Nov; 88(22):13310-21. PMID: 25210168; PMCID: PMC4249103.
  61. Streeck H, Lu R, Beckwith N, Milazzo M, Liu M, Routy JP, Little S, Jessen H, Kelleher AD, Hecht F, Sekaly RP, Alter G, Heckerman D, Carrington M, Rosenberg ES, Altfeld M. Emergence of individual HIV-specific CD8 T cell responses during primary HIV-1 infection can determine long-term disease outcome. J Virol. 2014 Nov; 88(21):12793-801. PMID: 25165102; PMCID: PMC4248916.
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  123. Wang YE, Li B, Carlson JM, Streeck H, Gladden AD, Goodman R, Schneidewind A, Power KA, Toth I, Frahm N, Alter G, Brander C, Carrington M, Walker BD, Altfeld M, Heckerman D, Allen TM. Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1. J Virol. 2009 Feb; 83(4):1845-55. PMID: 19036810; PMCID: PMC2643763.
  124. Minkis K, Kavanagh DG, Alter G, Bogunovic D, O'Neill D, Adams S, Pavlick A, Walker BD, Brockman MA, Gandhi RT, Bhardwaj N. Type 2 Bias of T cells expanded from the blood of melanoma patients switched to type 1 by IL-12p70 mRNA-transfected dendritic cells. Cancer Res. 2008 Nov 15; 68(22):9441-50. PMID: 19010919; PMCID: PMC2628575.
  125. Meier A, Fisher A, Sidhu HK, Chang JJ, Wen TF, Streeck H, Alter G, Silvestri G, Altfeld M. Rapid loss of dendritic cell and monocyte responses to TLR ligands following venipuncture. J Immunol Methods. 2008 Dec 31; 339(2):132-40. PMID: 18848564; PMCID: PMC2613681.
  126. Alter G, Rihn S, Streeck H, Teigen N, Piechocka-Trocha A, Moss K, Cohen K, Meier A, Pereyra F, Walker B, Altfeld M. Ligand-independent exhaustion of killer immunoglobulin-like receptor-positive CD8+ T cells in human immunodeficiency virus type 1 infection. J Virol. 2008 Oct; 82(19):9668-77. PMID: 18579582; PMCID: PMC2546972.
  127. Minkis K, Kavanagh D, O'Neill D, Alter G, Sunderji S, Adams S, Walker B, Pavlick AC, Gandhi R, Bhardwaj N. Transfection of dendritic cells (DCs) with mRNA encoding IL-12p70 enhances anti-tumor immunity in melanoma patients. J Clin Oncol. 2008 May 20; 26(15_suppl):22217. PMID: 27950264.
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  128. Thomas R, Yamada E, Alter G, Martin MP, Bashirova AA, Norman PJ, Altfeld M, Parham P, Anderson SK, McVicar DW, Carrington M. Novel KIR3DL1 alleles and their expression levels on NK cells: convergent evolution of KIR3DL1 phenotype variation? J Immunol. 2008 May 15; 180(10):6743-50. PMID: 18453594; PMCID: PMC2689389.
  129. Streeck H, Brumme ZL, Anastario M, Cohen KW, Jolin JS, Meier A, Brumme CJ, Rosenberg ES, Alter G, Allen TM, Walker BD, Altfeld M. Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells. PLoS Med. 2008 May 06; 5(5):e100. PMID: 18462013; PMCID: PMC2365971.
  130. Meier A, Bagchi A, Sidhu HK, Alter G, Suscovich TJ, Kavanagh DG, Streeck H, Brockman MA, LeGall S, Hellman J, Altfeld M. Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands. AIDS. 2008 Mar 12; 22(5):655-8. PMID: 18317010; PMCID: PMC2810187.
  131. Streeck H, Cohen KW, Jolin JS, Brockman MA, Meier A, Power KA, Waring MT, Alter G, Altfeld M. Rapid ex vivo isolation and long-term culture of human Th17 cells. J Immunol Methods. 2008 Apr 20; 333(1-2):115-25. PMID: 18314131.
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  132. Alter G, Martin MP, Teigen N, Carr WH, Suscovich TJ, Schneidewind A, Streeck H, Waring M, Meier A, Brander C, Lifson JD, Allen TM, Carrington M, Altfeld M. Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes. J Exp Med. 2007 Nov 26; 204(12):3027-36. PMID: 18025129; PMCID: PMC2118524.
  133. Pascal V, Yamada E, Martin MP, Alter G, Altfeld M, Metcalf JA, Baseler MW, Adelsberger JW, Carrington M, Anderson SK, McVicar DW. Detection of KIR3DS1 on the cell surface of peripheral blood NK cells facilitates identification of a novel null allele and assessment of KIR3DS1 expression during HIV-1 infection. J Immunol. 2007 Aug 01; 179(3):1625-33. PMID: 17641029.
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  134. Alter G, Suscovich TJ, Teigen N, Meier A, Streeck H, Brander C, Altfeld M. Single-stranded RNA derived from HIV-1 serves as a potent activator of NK cells. J Immunol. 2007 Jun 15; 178(12):7658-66. PMID: 17548602.
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  135. Meier A, Alter G, Frahm N, Sidhu H, Li B, Bagchi A, Teigen N, Streeck H, Stellbrink HJ, Hellman J, van Lunzen J, Altfeld M. MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded Toll-like receptor ligands. J Virol. 2007 Aug; 81(15):8180-91. PMID: 17507480; PMCID: PMC1951290.
  136. Streeck H, Lichterfeld M, Alter G, Meier A, Teigen N, Yassine-Diab B, Sidhu HK, Little S, Kelleher A, Routy JP, Rosenberg ES, Sekaly RP, Walker BD, Altfeld M. Recognition of a defined region within p24 gag by CD8+ T cells during primary human immunodeficiency virus type 1 infection in individuals expressing protective HLA class I alleles. J Virol. 2007 Jul; 81(14):7725-31. PMID: 17494064; PMCID: PMC1933382.
  137. Lakshmanan V, Alter G, Altfeld M, Bhardwaj N. Biology of plasmacytoid dendritic cells and natural killer cells in HIV-1 infection. Curr Opin HIV AIDS. 2007 May; 2(3):189-200. PMID: 19372886.
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  138. Alter G, Teigen N, Ahern R, Streeck H, Meier A, Rosenberg ES, Altfeld M. Evolution of innate and adaptive effector cell functions during acute HIV-1 infection. J Infect Dis. 2007 May 15; 195(10):1452-60. PMID: 17436225.
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  139. Altfeld M, Kalife ET, Qi Y, Streeck H, Lichterfeld M, Johnston MN, Burgett N, Swartz ME, Yang A, Alter G, Yu XG, Meier A, Rockstroh JK, Allen TM, Jessen H, Rosenberg ES, Carrington M, Walker BD. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1. PLoS Med. 2006 Oct; 3(10):e403. PMID: 17076553; PMCID: PMC1626551.
  140. Alter G, Altfeld M. NK cell function in HIV-1 infection. Curr Mol Med. 2006 Sep; 6(6):621-9. PMID: 17022732.
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  141. Streeck H, Jessen H, Alter G, Teigen N, Waring MT, Jessen A, Stahmer I, van Lunzen J, Lichterfeld M, Gao X, Allen TM, Carrington M, Walker BD, Rockstroh JK, Altfeld M. Immunological and virological impact of highly active antiretroviral therapy initiated during acute HIV-1 infection. J Infect Dis. 2006 Sep 15; 194(6):734-9. PMID: 16941338.
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  142. Alter G, Suscovich TJ, Kleyman M, Teigen N, Streeck H, Zaman MT, Meier A, Altfeld M. Low perforin and elevated SHIP-1 expression is associated with functional anergy of natural killer cells in chronic HIV-1 infection. AIDS. 2006 Jul 13; 20(11):1549-51. PMID: 16847410.
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  143. Bashirova AA, Bleiber G, Qi Y, Hutcheson H, Yamashita T, Johnson RC, Cheng J, Alter G, Goedert JJ, Buchbinder S, Hoots K, Vlahov D, May M, Maldarelli F, Jacobson L, O'brien SJ, Telenti A, Carrington M. Consistent effects of TSG101 genetic variability on multiple outcomes of exposure to human immunodeficiency virus type 1. J Virol. 2006 Jul; 80(14):6757-63. PMID: 16809281; PMCID: PMC1489017.
  144. Alter G, Altfeld M. Perspective natural killer cells: bridging innate and adaptive immunity? IAVI Rep. 2006 May-Jun; 10(3):1, 6-10. PMID: 20217934.
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  145. Allen TM, Yu XG, Kalife ET, Reyor LL, Lichterfeld M, John M, Cheng M, Allgaier RL, Mui S, Frahm N, Alter G, Brown NV, Johnston MN, Rosenberg ES, Mallal SA, Brander C, Walker BD, Altfeld M. De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection. J Virol. 2005 Oct; 79(20):12952-60. PMID: 16188997; PMCID: PMC1235830.
  146. Yu XG, Lichterfeld M, Perkins B, Kalife E, Mui S, Chen J, Cheng M, Kang W, Alter G, Brander C, Walker BD, Altfeld M. High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level. AIDS. 2005 Sep 23; 19(14):1449-56. PMID: 16135897.
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  147. Alter G, Teigen N, Davis BT, Addo MM, Suscovich TJ, Waring MT, Streeck H, Johnston MN, Staller KD, Zaman MT, Yu XG, Lichterfeld M, Basgoz N, Rosenberg ES, Altfeld M. Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection. Blood. 2005 Nov 15; 106(10):3366-9. PMID: 16002429.
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  148. Altfeld M, Allen TM, Kalife ET, Frahm N, Addo MM, Mothe BR, Rathod A, Reyor LL, Harlow J, Yu XG, Perkins B, Robinson LK, Sidney J, Alter G, Lichterfeld M, Sette A, Rosenberg ES, Goulder PJ, Brander C, Walker BD. The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design. J Virol. 2005 Apr; 79(8):5000-5. PMID: 15795285; PMCID: PMC1069570.
  149. Peretz Y, Alter G, Boisvert MP, Hatzakis G, Tsoukas CM, Bernard NF. Human immunodeficiency virus (HIV)-specific gamma interferon secretion directed against all expressed HIV genes: relationship to rate of CD4 decline. J Virol. 2005 Apr; 79(8):4908-17. PMID: 15795276; PMCID: PMC1069552.
  150. Alter G, Malenfant JM, Altfeld M. CD107a as a functional marker for the identification of natural killer cell activity. J Immunol Methods. 2004 Nov; 294(1-2):15-22. PMID: 15604012.
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  151. Alter G, Tsoukas CM, Rouleau D, Côté P, Routy JP, Sékaly RP, Bernard NF. Assessment of longitudinal changes in HIV-specific effector activity in subjects undergoing untreated primary HIV infection. AIDS. 2004 Oct 21; 18(15):1979-89. PMID: 15577619.
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  152. Alter G, Malenfant JM, Delabre RM, Burgett NC, Yu XG, Lichterfeld M, Zaunders J, Altfeld M. Increased natural killer cell activity in viremic HIV-1 infection. J Immunol. 2004 Oct 15; 173(8):5305-11. PMID: 15470077.
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  153. Lichterfeld M, Kaufmann DE, Yu XG, Mui SK, Addo MM, Johnston MN, Cohen D, Robbins GK, Pae E, Alter G, Wurcel A, Stone D, Rosenberg ES, Walker BD, Altfeld M. Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells. J Exp Med. 2004 Sep 20; 200(6):701-12. PMID: 15381726; PMCID: PMC2211961.
  154. Lichterfeld M, Yu XG, Waring MT, Mui SK, Johnston MN, Cohen D, Addo MM, Zaunders J, Alter G, Pae E, Strick D, Allen TM, Rosenberg ES, Walker BD, Altfeld M. HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha. Blood. 2004 Jul 15; 104(2):487-94. PMID: 15059848.
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  155. Alter G, Merchant A, Tsoukas CM, Rouleau D, LeBlanc RP, Côté P, Baril JG, Thomas R, Nguyen VK, Sékaly RP, Routy JP, Bernard NF. Human immunodeficiency virus (HIV)-specific effector CD8 T cell activity in patients with primary HIV infection. J Infect Dis. 2002 Mar 15; 185(6):755-65. PMID: 11920293.
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  156. Foster CS, Alter G, DeBarge LR, Raizman MB, Crabb JL, Santos CI, Feiler LS, Friedlaender MH. Efficacy and safety of rimexolone 1% ophthalmic suspension vs 1% prednisolone acetate in the treatment of uveitis. Am J Ophthalmol. 1996 Aug; 122(2):171-82. PMID: 8694085.
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