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Sharon G. Kujawa, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P50DC015857 (KUJAWA, SHARON G) Aug 2, 2017 - Jul 31, 2022
    NIH/NIDCD
    Cochlear Synaptopathy: Prevalence, Diagnosis and Functional Consequences
    Role: Principal Investigator
  2. R01DC008577 (KUJAWA, SHARON G) Mar 5, 2008 - Feb 28, 2014
    NIH/NIDCD
    Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss
    Role: Principal Investigator
  3. R21DC004983 (KUJAWA, SHARON) Aug 1, 2001 - Jul 31, 2004
    NIH/NIDCD
    Genetics of Noise Resistance in the Aging Ear
    Role: Principal Investigator
  4. F32DC000180 (KUJAWA, SHARON) Jul 1, 1995
    NIH/NIDCD
    PROTECTIVE EFFECTS OF EFFERENT FEEDBACK TO THE COCHLEA
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kujawa SG, Liberman MC. Translating animal models to human therapeutics in noise-induced and age-related hearing loss. Hear Res. 2019 Jun; 377:44-52. PMID: 30903954.
    Citations:    
  2. Parthasarathy A, Bartlett EL, Kujawa SG. Age-related Changes in Neural Coding of Envelope Cues: Peripheral Declines and Central Compensation. Neuroscience. 2019 May 21; 407:21-31. PMID: 30553793.
    Citations:    Fields:    
  3. Bramhall NF, McMillan GP, Kujawa SG, Konrad-Martin D. Use of non-invasive measures to predict cochlear synapse counts. Hear Res. 2018 Dec; 370:113-119. PMID: 30366194.
    Citations:    Fields:    
  4. Shrestha BR, Chia C, Wu L, Kujawa SG, Liberman MC, Goodrich LV. Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity. Cell. 2018 08 23; 174(5):1229-1246.e17. PMID: 30078709.
    Citations:    Fields:    
  5. Parthasarathy A, Kujawa SG. Synaptopathy in the Aging Cochlea: Characterizing Early-Neural Deficits in Auditory Temporal Envelope Processing. J Neurosci. 2018 Aug 08; 38(32):7108-7119. PMID: 29976623.
    Citations: 1     Fields:    
  6. Liberman MC, Kujawa SG. Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms. Hear Res. 2017 06; 349:138-147. PMID: 28087419.
    Citations: 27     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  7. Ryan AF, Kujawa SG, Hammill T, Le Prell C, Kil J. Temporary and Permanent Noise-induced Threshold Shifts: A Review of Basic and Clinical Observations. Otol Neurotol. 2016 09; 37(8):e271-5. PMID: 27518135.
    Citations: 4     Fields:    Translation:HumansAnimalsPHPublic Health
  8. Voss SE, Herrmann BS, Horton NJ, Amadei EA, Kujawa SG. Reflectance Measures from Infant Ears With Normal Hearing and Transient Conductive Hearing Loss. Ear Hear. 2016 Sep-Oct; 37(5):560-71. PMID: 27050773.
    Citations:    Fields:    Translation:HumansPHPublic Health
  9. Macias AA, Eappen S, Malikin I, Goldfarb J, Kujawa S, Konowitz PM, Kamani D, Randolph GW. Successful intraoperative electrophysiologic monitoring of the recurrent laryngeal nerve, a multidisciplinary approach: The Massachusetts Eye and Ear Infirmary monitoring collaborative protocol with experience in over 3000 cases. Head Neck. 2016 10; 38(10):1487-94. PMID: 27062311.
    Citations: 2     Fields:    Translation:Humans
  10. Tandon V, Kang WS, Robbins TA, Spencer AJ, Kim ES, McKenna MJ, Kujawa SG, Fiering J, Pararas EE, Mescher MJ, Sewell WF, Borenstein JT. Microfabricated reciprocating micropump for intracochlear drug delivery with integrated drug/fluid storage and electronically controlled dosing. Lab Chip. 2016 Mar 07; 16(5):829-46. PMID: 26778829.
    Citations: 3     Fields:    Translation:HumansAnimals
  11. Fernandez KA, Jeffers PW, Lall K, Liberman MC, Kujawa SG. Aging after noise exposure: acceleration of cochlear synaptopathy in "recovered" ears. J Neurosci. 2015 May 13; 35(19):7509-20. PMID: 25972177.
    Citations: 40     Fields:    Translation:AnimalsCellsPHPublic Health
  12. Tandon V, Kang WS, Spencer AJ, Kim ES, Pararas EE, McKenna MJ, Kujawa SG, Mescher MJ, Fiering J, Sewell WF, Borenstein JT. Microfabricated infuse-withdraw micropump component for an integrated inner-ear drug-delivery platform. Biomed Microdevices. 2015 Apr; 17(2):37. PMID: 25686902.
    Citations:    Fields:    Translation:Animals
  13. Kujawa SG, Liberman MC. Synaptopathy in the noise-exposed and aging cochlea: Primary neural degeneration in acquired sensorineural hearing loss. Hear Res. 2015 Dec; 330(Pt B):191-9. PMID: 25769437.
    Citations: 70     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  14. Remenschneider AK, Lookabaugh S, Aliphas A, Brodsky JR, Devaiah AK, Dagher W, Grundfast KM, Heman-Ackah SE, Rubin S, Sillman J, Tsai AC, Vecchiotti M, Kujawa SG, Lee DJ, Quesnel AM. Otologic outcomes after blast injury: the Boston Marathon experience. Otol Neurotol. 2014 Dec; 35(10):1825-34. PMID: 25393974.
    Citations: 6     Fields:    Translation:Humans
  15. Street VA, Kujawa SG, Manichaikul A, Broman KW, Kallman JC, Shilling DJ, Iwata AJ, Robinson LC, Robbins CA, Li J, Liberman MC, Tempel BL. Resistance to noise-induced hearing loss in 129S6 and MOLF mice: identification of independent, overlapping, and interacting chromosomal regions. J Assoc Res Otolaryngol. 2014 Oct; 15(5):721-38. PMID: 24952082.
    Citations: 2     Fields:    Translation:Animals
  16. Liberman MC, Kujawa SG. Hot Topics-Hidden hearing loss: Permanent cochlear-nerve degeneration after temporary noise-induced threshold shift. J Acoust Soc Am. 2014 Apr; 135(4):2311. PMID: 25235676.
    Citations:    
  17. Sergeyenko Y, Lall K, Liberman MC, Kujawa SG. Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline. J Neurosci. 2013 Aug 21; 33(34):13686-94. PMID: 23966690.
    Citations: 105     Fields:    Translation:AnimalsCells
  18. Furman AC, Kujawa SG, Liberman MC. Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates. J Neurophysiol. 2013 Aug; 110(3):577-86. PMID: 23596328.
    Citations: 120     Fields:    Translation:AnimalsCells
  19. Seixas NS, Neitzel R, Stover B, Sheppard L, Feeney P, Mills D, Kujawa S. 10-Year prospective study of noise exposure and hearing damage among construction workers. Occup Environ Med. 2012 Sep; 69(9):643-50. PMID: 22693267.
    Citations: 12     Fields:    Translation:HumansPHPublic Health
  20. Makary CA, Shin J, Kujawa SG, Liberman MC, Merchant SN. Age-related primary cochlear neuronal degeneration in human temporal bones. J Assoc Res Otolaryngol. 2011 Dec; 12(6):711-7. PMID: 21748533.
    Citations: 71     Fields:    Translation:HumansCells
  21. Lin HW, Furman AC, Kujawa SG, Liberman MC. Primary neural degeneration in the Guinea pig cochlea after reversible noise-induced threshold shift. J Assoc Res Otolaryngol. 2011 Oct; 12(5):605-16. PMID: 21688060.
    Citations: 122     Fields:    Translation:AnimalsCellsPHPublic Health
  22. Pararas EE, Chen Z, Fiering J, Mescher MJ, Kim ES, McKenna MJ, Kujawa SG, Borenstein JT, Sewell WF. Kinetics of reciprocating drug delivery to the inner ear. J Control Release. 2011 Jun 10; 152(2):270-7. PMID: 21385596.
    Citations: 7     Fields:    Translation:AnimalsCells
  23. Peppi M, Kujawa SG, Sewell WF. A corticosteroid-responsive transcription factor, promyelocytic leukemia zinc finger protein, mediates protection of the cochlea from acoustic trauma. J Neurosci. 2011 Jan 12; 31(2):735-41. PMID: 21228182.
    Citations: 7     Fields:    Translation:AnimalsCellsPHPublic Health
  24. McCall AA, Swan EE, Borenstein JT, Sewell WF, Kujawa SG, McKenna MJ. Drug delivery for treatment of inner ear disease: current state of knowledge. Ear Hear. 2010 Apr; 31(2):156-65. PMID: 19952751.
    Citations: 24     Fields:    Translation:Humans
  25. Chen Z, Kujawa SG, Sewell WF. Functional roles of high-affinity glutamate transporters in cochlear afferent synaptic transmission in the mouse. J Neurophysiol. 2010 May; 103(5):2581-6. PMID: 20220082.
    Citations: 6     Fields:    Translation:AnimalsCells
  26. Sewell WF, Borenstein JT, Chen Z, Fiering J, Handzel O, Holmboe M, Kim ES, Kujawa SG, McKenna MJ, Mescher MM, Murphy B, Swan EE, Peppi M, Tao S. Development of a microfluidics-based intracochlear drug delivery device. Audiol Neurootol. 2009; 14(6):411-22. PMID: 19923811.
    Citations: 11     Fields:    Translation:Animals
  27. Kujawa SG, Liberman MC. Adding insult to injury: cochlear nerve degeneration after "temporary" noise-induced hearing loss. J Neurosci. 2009 Nov 11; 29(45):14077-85. PMID: 19906956.
    Citations: 419     Fields:    Translation:AnimalsCellsPHPublic Health
  28. Chen Z, Peppi M, Kujawa SG, Sewell WF. Regulated expression of surface AMPA receptors reduces excitotoxicity in auditory neurons. J Neurophysiol. 2009 Aug; 102(2):1152-9. PMID: 19515954.
    Citations: 16     Fields:    Translation:AnimalsCells
  29. Mescher MJ, Swan EE, Fiering J, Holmboe ME, Sewell WF, Kujawa SG, McKenna MJ, Borenstein JT. Fabrication Methods and Performance of Low-Permeability Microfluidic Components for a Miniaturized Wearable Drug Delivery System. J Microelectromech Syst. 2009 Jun 01; 18(3):501-510. PMID: 20852729.
    Citations: 9     
  30. Fiering J, Mescher MJ, Leary Swan EE, Holmboe ME, Murphy BA, Chen Z, Peppi M, Sewell WF, McKenna MJ, Kujawa SG, Borenstein JT. Local drug delivery with a self-contained, programmable, microfluidic system. Biomed Microdevices. 2009 Jun; 11(3):571-8. PMID: 19089621.
    Citations: 12     Fields:    Translation:AnimalsCells
  31. Swan EE, Peppi M, Chen Z, Green KM, Evans JE, McKenna MJ, Mescher MJ, Kujawa SG, Sewell WF. Proteomics analysis of perilymph and cerebrospinal fluid in mouse. Laryngoscope. 2009 May; 119(5):953-8. PMID: 19358201.
    Citations: 11     Fields:    Translation:Animals
  32. Handzel O, Wang H, Fiering J, Borenstein JT, Mescher MJ, Swan EE, Murphy BA, Chen Z, Peppi M, Sewell WF, Kujawa SG, McKenna MJ. Mastoid cavity dimensions and shape: method of measurement and virtual fitting of implantable devices. Audiol Neurootol. 2009; 14(5):308-14. PMID: 19372649.
    Citations: 8     Fields:    Translation:Humans
  33. Chen Z, Kujawa SG, Sewell WF. Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors. Nat Neurosci. 2007 Oct; 10(10):1238-40. PMID: 17828255.
    Citations: 22     Fields:    Translation:AnimalsCells
  34. Goldman B, Sheppard L, Kujawa SG, Seixas NS. Modeling distortion product otoacoustic emission input/output functions using segmented regression. J Acoust Soc Am. 2006 Nov; 120(5 Pt 1):2764-76. PMID: 17139737.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  35. Lin MY, Timmer FC, Oriel BS, Zhou G, Guinan JJ, Kujawa SG, Herrmann BS, Merchant SN, Rauch SD. Vestibular evoked myogenic potentials (VEMP) can detect asymptomatic saccular hydrops. Laryngoscope. 2006 Jun; 116(6):987-92. PMID: 16735912.
    Citations: 20     Fields:    Translation:Humans
  36. Timmer FC, Zhou G, Guinan JJ, Kujawa SG, Herrmann BS, Rauch SD. Vestibular evoked myogenic potential (VEMP) in patients with Ménière's disease with drop attacks. Laryngoscope. 2006 May; 116(5):776-9. PMID: 16652086.
    Citations: 13     Fields:    Translation:Humans
  37. Kujawa SG, Liberman MC. Acceleration of age-related hearing loss by early noise exposure: evidence of a misspent youth. J Neurosci. 2006 Feb 15; 26(7):2115-23. PMID: 16481444.
    Citations: 135     Fields:    Translation:AnimalsPHPublic Health
  38. Zehnder AF, Kristiansen AG, Adams JC, Kujawa SG, Merchant SN, McKenna MJ. Osteoprotegrin knockout mice demonstrate abnormal remodeling of the otic capsule and progressive hearing loss. Laryngoscope. 2006 Feb; 116(2):201-6. PMID: 16467704.
    Citations: 24     Fields:    Translation:Animals
  39. Chen Z, Kujawa SG, McKenna MJ, Fiering JO, Mescher MJ, Borenstein JT, Swan EE, Sewell WF. Inner ear drug delivery via a reciprocating perfusion system in the guinea pig. J Control Release. 2005 Dec 10; 110(1):1-19. PMID: 16274830.
    Citations: 30     Fields:    Translation:AnimalsCells
  40. Chen Z, Mikulec AA, McKenna MJ, Sewell WF, Kujawa SG. A method for intracochlear drug delivery in the mouse. J Neurosci Methods. 2006 Jan 15; 150(1):67-73. PMID: 16043228.
    Citations: 16     Fields:    Translation:Animals
  41. Seixas NS, Goldman B, Sheppard L, Neitzel R, Norton S, Kujawa SG. Prospective noise induced changes to hearing among construction industry apprentices. Occup Environ Med. 2005 May; 62(5):309-17. PMID: 15837852.
    Citations: 18     Fields:    Translation:HumansPHPublic Health
  42. Seixas NS, Kujawa SG, Norton S, Sheppard L, Neitzel R, Slee A. Predictors of hearing threshold levels and distortion product otoacoustic emissions among noise exposed young adults. Occup Environ Med. 2004 Nov; 61(11):899-907. PMID: 15477283.
    Citations: 11     Fields:    Translation:HumansPHPublic Health
  43. Rauch SD, Silveira MB, Zhou G, Kujawa SG, Wall C, Guinan JJ, Herrmann BS. Vestibular evoked myogenic potentials versus vestibular test battery in patients with Meniere's disease. Otol Neurotol. 2004 Nov; 25(6):981-6. PMID: 15547430.
    Citations: 3     Fields:    Translation:Humans
  44. Rauch SD, Zhou G, Kujawa SG, Guinan JJ, Herrmann BS. Vestibular evoked myogenic potentials show altered tuning in patients with Ménière's disease. Otol Neurotol. 2004 May; 25(3):333-8. PMID: 15129114.
    Citations: 29     Fields:    Translation:Humans
  45. Rosowski JJ, Brinsko KM, Tempel BI, Kujawa SG. The aging of the middle ear in 129S6/SvEvTac and CBA/CaJ mice: measurements of umbo velocity, hearing function, and the incidence of pathology. J Assoc Res Otolaryngol. 2003 Sep; 4(3):371-83. PMID: 14690055.
    Citations: 13     Fields:    Translation:Animals
  46. Kujawa SG, Liberman MC. Effects of olivocochlear feedback on distortion product otoacoustic emissions in guinea pig. J Assoc Res Otolaryngol. 2001 Sep; 2(3):268-78. PMID: 11669399.
    Citations: 20     Fields:    Translation:Animals
  47. Parkinson NJ, Olsson CL, Hallows JL, McKee-Johnson J, Keogh BP, Noben-Trauth K, Kujawa SG, Tempel BL. Mutant beta-spectrin 4 causes auditory and motor neuropathies in quivering mice. Nat Genet. 2001 Sep; 29(1):61-5. PMID: 11528393.
    Citations: 43     Fields:    Translation:Animals
  48. Gates GA, Schmid P, Kujawa SG, Nam B, D'Agostino R. Longitudinal threshold changes in older men with audiometric notches. Hear Res. 2000 Mar; 141(1-2):220-8. PMID: 10713509.
    Citations: 35     Fields:    Translation:Humans
  49. Kujawa SG, Liberman MC. Long-term sound conditioning enhances cochlear sensitivity. J Neurophysiol. 1999 Aug; 82(2):863-73. PMID: 10444683.
    Citations: 12     Fields:    Translation:Animals
  50. Brown MC, Kujawa SG, Duca ML. Single olivocochlear neurons in the guinea pig. I. Binaural facilitation of responses to high-level noise. J Neurophysiol. 1998 Jun; 79(6):3077-87. PMID: 9636109.
    Citations: 15     Fields:    Translation:AnimalsCellsPHPublic Health
  51. Brown MC, Kujawa SG, Liberman MC. Single olivocochlear neurons in the guinea pig. II. Response plasticity due to noise conditioning. J Neurophysiol. 1998 Jun; 79(6):3088-97. PMID: 9636110.
    Citations: 13     Fields:    Translation:AnimalsCellsPHPublic Health
  52. Kujawa SG, Liberman MC. Conditioning-related protection from acoustic injury: effects of chronic deefferentation and sham surgery. J Neurophysiol. 1997 Dec; 78(6):3095-106. PMID: 9405529.
    Citations: 34     Fields:    Translation:Animals
  53. Kujawa SG, Fallon M, Skellett RA, Bobbin RP. Time-varying alterations in the f2-f1 DPOAE response to continuous primary stimulation. II. Influence of local calcium-dependent mechanisms. Hear Res. 1996 Aug; 97(1-2):153-64. PMID: 8844195.
    Citations: 2     Fields:    Translation:AnimalsCells
  54. Kujawa SG, Fallon M, Bobbin RP. Time-varying alterations in the f2-f1 DPOAE response to continuous primary stimulation. I: Response characterization and contribution of the olivocochlear efferents. Hear Res. 1995 May; 85(1-2):142-54. PMID: 7559170.
    Citations: 8     Fields:    Translation:AnimalsCells
  55. Goldsmith JD, Kujawa SG, McLaren JD, Bledsoe SC. In vivo release of neuroactive amino acids from the inferior colliculus of the guinea pig using brain microdialysis. Hear Res. 1995 Mar; 83(1-2):80-8. PMID: 7607993.
    Citations: 6     Fields:    Translation:AnimalsCells
  56. Kujawa SG, Fallon M, Bobbin RP. ATP antagonists cibacron blue, basilen blue and suramin alter sound-evoked responses of the cochlea and auditory nerve. Hear Res. 1994 Aug; 78(2):181-8. PMID: 7982811.
    Citations: 7     Fields:    Translation:Animals
  57. Kujawa SG, Erostegui C, Fallon M, Crist J, Bobbin RP. Effects of adenosine 5'-triphosphate and related agonists on cochlear function. Hear Res. 1994 Jun 01; 76(1-2):87-100. PMID: 7928720.
    Citations: 13     Fields:    Translation:AnimalsCells
  58. Kujawa SG, Glattke TJ, Fallon M, Bobbin RP. A nicotinic-like receptor mediates suppression of distortion product otoacoustic emissions by contralateral sound. Hear Res. 1994 Apr; 74(1-2):122-34. PMID: 8040083.
    Citations: 10     Fields:    Translation:AnimalsCells
  59. Kujawa SG, Glattke TJ, Fallon M, Bobbin RP. Contralateral sound suppresses distortion product otoacoustic emissions through cholinergic mechanisms. Hear Res. 1993 Jun; 68(1):97-106. PMID: 8376219.
    Citations: 3     Fields:    Translation:AnimalsCells
  60. Kujawa SG, Fallon M, Bobbin RP. Intracochlear salicylate reduces low-intensity acoustic and cochlear microphonic distortion products. Hear Res. 1992 Dec; 64(1):73-80. PMID: 1490903.
    Citations: 8     Fields:    Translation:Animals
  61. Kujawa SG, Glattke TJ, Fallon M, Bobbin RP. Intracochlear application of acetylcholine alters sound-induced mechanical events within the cochlear partition. Hear Res. 1992 Aug; 61(1-2):106-16. PMID: 1326504.
    Citations: 4     Fields:    Translation:AnimalsCells
  62. Bobbin RP, Fallon M, Kujawa SG. Magnitude of the negative summating potential varies with perilymph calcium levels. Hear Res. 1991 Nov; 56(1-2):101-10. PMID: 1663103.
    Citations: 2     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.