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profileAnand Shrikant Dighe, Ph.D., M.D.

TitleAssociate Professor of Pathology
InstitutionMassachusetts General Hospital
DepartmentPathology
AddressMassachusetts General Hospital
Gray 5, Core Laboratory
55 Fruit St
Boston MA 02114
Phone617/726-7902
Fax617/726-9206
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Baron JM, Dighe AS, Flood JG. Case 3-2017: A Man with Cardiac Sarcoidosis and New Diplopia and Weakness. N Engl J Med. 2017 05 11; 376(19):1897. PMID: 28490000.
    View in: PubMed
  2. Nagarur A, Axelrod L, Dighe AS. Case 9-2017. A 27-Year-Old Woman with Nausea, Vomiting, Confusion, and Hyponatremia. N Engl J Med. 2017 03 23; 376(12):1159-1167. PMID: 28328333.
    View in: PubMed
  3. Luo Y, Szolovits P, Dighe AS, Baron JM. Using Machine Learning to Predict Laboratory Test Results. Am J Clin Pathol. 2016 Jun; 145(6):778-88. PMID: 27329638.
    View in: PubMed
  4. Garcia CA, Baron JM, Beckwith BA, Brodsky V, Dighe AS, Gudewicz TM, Kim JY, Klepeis VE, Lane WJ, Lee RE, Levy BP, Mahowald MA, Mandelker D, McClintock DS, Quinn AM, Rao LK, Riedlinger GM, Rudolf J, Gilbertson JR. Environmental components and methods for engaging pathology residents in informatics training. J Pathol Inform. 2015; 6:42. PMID: 26167386; PMCID: PMC4498313.
  5. Louis DN, Feldman M, Carter AB, Dighe AS, Pfeifer JD, Bry L, Almeida JS, Saltz J, Braun J, Tomaszewski JE, Gilbertson JR, Sinard JH, Gerber GK, Galli SJ, Golden JA, Becich MJ. Computational Pathology: A Path Ahead. Arch Pathol Lab Med. 2016 Jan; 140(1):41-50. PMID: 26098131; PMCID: PMC4996078.
  6. White BA, Baron JM, Dighe AS, Camargo CA, Brown DF. Applying Lean methodologies reduces ED laboratory turnaround times. Am J Emerg Med. 2015 Nov; 33(11):1572-6. PMID: 26145581; PMCID: PMC4628563 [Available on 11/01/16].
  7. Baron JM, Cheng XS, Bazari H, Bhan I, Lofgren C, Jaromin RT, Lewandrowski KB, Dighe AS. Enhanced creatinine and estimated glomerular filtration rate reporting to facilitate detection of acute kidney injury. Am J Clin Pathol. 2015 Jan; 143(1):42-9. PMID: 25511141.
    View in: PubMed
  8. Iyasere CA, Simmons LH, Fintelmann FJ, Dighe AS. Case records of the Massachusetts General Hospital. Case 38-2014. An 87-year-old man with sore throat, hoarseness, fatigue, and dyspnea. N Engl J Med. 2014 Dec 11; 371(24):2321-7. PMID: 25494272.
    View in: PubMed
  9. Louis DN, Gerber GK, Baron JM, Bry L, Dighe AS, Getz G, Higgins JM, Kuo FC, Lane WJ, Michaelson JS, Le LP, Mermel CH, Gilbertson JR, Golden JA. Computational pathology: an emerging definition. Arch Pathol Lab Med. 2014 Sep; 138(9):1133-8. PMID: 25171694.
    View in: PubMed
  10. Branda JA, Dighe AS, Dzik W, Ferraro MJ, Flood J, Lee-Lewandrowski E, Makar R, Mandokolathur M, Rosenberg ES, Saidman S, Sluss P, Sohani AR, Stowell C, Van Cott EM, Lewandrowski KB. The practice of clinical pathology: a quantitative description of laboratory director activities at a large academic medical center. Am J Clin Pathol. 2014 Aug; 142(2):144-9. PMID: 25015853.
    View in: PubMed
  11. Baron JM, Dighe AS, Arnaout R, Balis UJ, Black-Schaffer WS, Carter AB, Henricks WH, Higgins JM, Jackson BR, Kim J, Klepeis VE, Le LP, Louis DN, Mandelker D, Mermel CH, Michaelson JS, Nagarajan R, Platt ME, Quinn AM, Rao L, Shirts BH, Gilbertson JR. The 2013 symposium on pathology data integration and clinical decision support and the current state of field. J Pathol Inform. 2014; 5(1):2. PMID: 24672737; PMCID: PMC3952400.
  12. Roy CL, Rothschild JM, Dighe AS, Schiff GD, Graydon-Baker E, Lenoci-Edwards J, Dwyer C, Khorasani R, Gandhi TK. An initiative to improve the management of clinically significant test results in a large health care network. Jt Comm J Qual Patient Saf. 2013 Nov; 39(11):517-27. PMID: 24294680.
    View in: PubMed
  13. Baron JM, Dighe AS. The role of informatics and decision support in utilization management. Clin Chim Acta. 2014 Jan 01; 427:196-201. PMID: 24084507.
    View in: PubMed
  14. Puig A, Dighe AS. Case records of the Massachusetts General Hospital. Case 20-2013. A 29-year-old man with anemia and jaundice. N Engl J Med. 2013 Jun 27; 368(26):2502-9. PMID: 23802518.
    View in: PubMed
  15. Lee RE, McClintock DS, Balis UJ, Baron JM, Becich MJ, Beckwith BA, Brodsky VB, Carter AB, Dighe AS, Haghighi M, Hipp JD, Henricks WH, Kim JY, Klepseis VE, Kuo FC, Lane WJ, Levy BP, Onozato ML, Park SL, Sinard JH, Tuthill MJ, Gilbertson JR. Pathology informatics fellowship retreats: The use of interactive scenarios and case studies as pathology informatics teaching tools. J Pathol Inform. 2012; 3:41. PMID: 23248762; PMCID: PMC3519095.
  16. Greenwald JL, McDermott S, Dighe AS. Case records of the Massachusetts General Hospital. Case 35-2012. A 69-year-old chronically ill man with weakness, anorexia, and diffuse pain. N Engl J Med. 2012 Nov 15; 367(20):1940-8. PMID: 23150962.
    View in: PubMed
  17. Baron JM, Mermel CH, Lewandrowski KB, Dighe AS. Detection of preanalytic laboratory testing errors using a statistically guided protocol. Am J Clin Pathol. 2012 Sep; 138(3):406-13. PMID: 22912358.
    View in: PubMed
  18. McClintock DS, Levy BP, Lane WJ, Lee RE, Baron JM, Klepeis VE, Onozato ML, Kim J, Dighe AS, Beckwith BA, Kuo F, Black-Schaffer S, Gilbertson JR. A core curriculum for clinical fellowship training in pathology informatics. J Pathol Inform. 2012; 3:31. PMID: 23024890; PMCID: PMC3445301.
  19. Puig A, Mino-Kenudson M, Dighe AS. Case records of the Massachusetts General Hospital. Case 13-2012. A 62-year-old man with paresthesias, weight loss, jaundice, and anemia. N Engl J Med. 2012 Apr 26; 366(17):1626-33. PMID: 22533579.
    View in: PubMed
  20. Gilbertson JR, McClintock DS, Lee RE, Onozato M, Kuo FC, Beckwith BA, Yagi Y, Dighe AS, Gudewicz TM, Le LP, Wilbur DC, Kim JY, Brodsky VB, Black-Schaffer S. Clinical fellowship training in pathology informatics: A program description. J Pathol Inform. 2012; 3:11. PMID: 22530179; PMCID: PMC3327041.
  21. Baron JM, Lewandrowski KB, Kamis IK, Singh B, Belkziz SM, Dighe AS. A novel strategy for evaluating the effects of an electronic test ordering alert message: Optimizing cardiac marker use. J Pathol Inform. 2012; 3:3. PMID: 22439123; PMCID: PMC3307227.
  22. Rhee EP, Scott JA, Dighe AS. Case records of the Massachusetts General Hospital. Case 4-2012. A 37-year-old man with muscle pain, weakness, and weight loss. N Engl J Med. 2012 Feb 09; 366(6):553-60. PMID: 22316449.
    View in: PubMed
  23. Omert L, Popovsky MA. Laboratory test utilization. Am J Clin Pathol. 2012 Jan; 137(1):165-6; author reply 166. PMID: 22180493.
    View in: PubMed
  24. Baron JM, Dighe AS. Computerized provider order entry in the clinical laboratory. J Pathol Inform. 2011; 2:35. PMID: 21886891; PMCID: PMC3162747.
  25. Kim JY, Kamis IK, Singh B, Batra S, Dixon RH, Dighe AS. Implementation of computerized add-on testing for hospitalized patients in a large academic medical center. Clin Chem Lab Med. 2011 May; 49(5):845-50. PMID: 21303296.
    View in: PubMed
  26. Kim JY, Dzik WH, Dighe AS, Lewandrowski KB. Utilization management in a large urban academic medical center: a 10-year experience. Am J Clin Pathol. 2011 Jan; 135(1):108-18. PMID: 21173132.
    View in: PubMed
  27. Grenache DG, Greene DN, Dighe AS, Fantz CR, Hoefner D, McCudden C, Sokoll L, Wiley CL, Gronowski AM. Falsely decreased human chorionic gonadotropin (hCG) results due to increased concentrations of the free beta subunit and the beta core fragment in quantitative hCG assays. Clin Chem. 2010 Dec; 56(12):1839-44. PMID: 20930131.
    View in: PubMed
  28. Kim JY, Gudewicz TM, Dighe AS, Gilbertson JR. The pathology informatics curriculum wiki: Harnessing the power of user-generated content. J Pathol Inform. 2010 Jul 13; 1. PMID: 20805963; PMCID: PMC2929539.
  29. Grisson R, Kim JY, Brodsky V, Kamis IK, Singh B, Belkziz SM, Batra S, Myers HJ, Demyanov A, Dighe AS. A novel class of laboratory middleware. Promoting information flow and improving computerized provider order entry. Am J Clin Pathol. 2010 Jun; 133(6):860-9. PMID: 20472843.
    View in: PubMed
  30. Holick MF, Lim R, Dighe AS. Case records of the Massachusetts General Hospital. Case 3-2009. A 9-month-old boy with seizures. N Engl J Med. 2009 Jan 22; 360(4):398-407. PMID: 19164191.
    View in: PubMed
  31. Kim JY, Patel S, Dighe AS. False-positive crystals in urine from contamination by Multistix 10 SG reagent strips for urinalysis. Lab Hematol. 2009; 15(4):35-7. PMID: 19923103.
    View in: PubMed
  32. Dighe AS, Jones JB, Parham S, Lewandrowski KB. Survey of critical value reporting and reduction of false-positive critical value results. Arch Pathol Lab Med. 2008 Oct; 132(10):1666-71. PMID: 18834227.
    View in: PubMed
  33. Nero C, Dighe AS. Analysis of pathology department Web sites and practical recommendations. Arch Pathol Lab Med. 2008 Sep; 132(9):1423-7. PMID: 18788853.
    View in: PubMed
  34. Dighe AS, Makar RS, Lewandrowski KB. Medicolegal liability in laboratory medicine. Semin Diagn Pathol. 2007 May; 24(2):98-107. PMID: 17633351.
    View in: PubMed
  35. Laposata M, Dighe A. "Pre-pre" and "post-post" analytical error: high-incidence patient safety hazards involving the clinical laboratory. Clin Chem Lab Med. 2007; 45(6):712-9. PMID: 17579522.
    View in: PubMed
  36. Blechner M, Kish J, Chadaga V, Dighe AS. Analysis of search in an online clinical laboratory manual. Am J Clin Pathol. 2006 Aug; 126(2):208-14. PMID: 16891195.
    View in: PubMed
  37. Dighe AS, Rao A, Coakley AB, Lewandrowski KB. Analysis of laboratory critical value reporting at a large academic medical center. Am J Clin Pathol. 2006 May; 125(5):758-64. PMID: 16707379.
    View in: PubMed
  38. Dighe AS, Moy JM, Hayes FJ, Sluss PM. High-resolution reference ranges for estradiol, luteinizing hormone, and follicle-stimulating hormone in men and women using the AxSYM assay system. Clin Biochem. 2005 Feb; 38(2):175-9. PMID: 15642281.
    View in: PubMed
  39. Laposata ME, Laposata M, Van Cott EM, Buchner DS, Kashalo MS, Dighe AS. Physician survey of a laboratory medicine interpretive service and evaluation of the influence of interpretations on laboratory test ordering. Arch Pathol Lab Med. 2004 Dec; 128(12):1424-7. PMID: 15578888.
    View in: PubMed
  40. Dighe AS, Laposata M. Making the laboratory a partner in patient safety. Clin Leadersh Manag Rev. 2004 Nov-Dec; 18(6):356-60. PMID: 15597558.
    View in: PubMed
  41. Smogorzewska A, Flood JG, Long WH, Dighe AS. Paraprotein interference in automated chemistry analyzers. Clin Chem. 2004 Sep; 50(9):1691-3. PMID: 15331512.
    View in: PubMed
  42. Dighe AS, Sluss PM. Improved detection of serum estradiol after sample extraction procedure. Clin Chem. 2004 Apr; 50(4):764-6. PMID: 15044337.
    View in: PubMed
  43. Dighe AS, Hayes FJ, Khosravi J, Bodani U, Sluss PM. Comparison of inhibin A immunoassays: recommendation for adoption of standardized reporting. Clin Chem. 2004 Apr; 50(4):767-9. PMID: 15044338.
    View in: PubMed
  44. Harris KR, Dighe AS. Laboratory testing for viral hepatitis. Am J Clin Pathol. 2002 Dec; 118 Suppl:S18-25. PMID: 14569810.
    View in: PubMed
  45. Kratz A, Soderberg BL, Szczepiorkowski ZM, Dighe AS, Versalovic J, Laposata M. The generation of narrative interpretations in laboratory medicine: a description of service-specific sign-out rounds. Am J Clin Pathol. 2001 Dec; 116 Suppl:S133-40. PMID: 11993699.
    View in: PubMed
  46. Dighe AS, Soderberg BL, Laposata M. Narrative interpretations for clinical laboratory evaluations: an overview. Am J Clin Pathol. 2001 Dec; 116 Suppl:S123-8. PMID: 11993697.
    View in: PubMed
  47. Kaplan DH, Shankaran V, Dighe AS, Stockert E, Aguet M, Old LJ, Schreiber RD. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7556-61. PMID: 9636188; PMCID: PMC22681.
  48. Szabo SJ, Dighe AS, Gubler U, Murphy KM. Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J Exp Med. 1997 Mar 03; 185(5):817-24. PMID: 9120387; PMCID: PMC2196166.
  49. Meraz MA, White JM, Sheehan KC, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell D, Carver-Moore K, DuBois RN, Clark R, Aguet M, Schreiber RD. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell. 1996 Feb 09; 84(3):431-42. PMID: 8608597.
    View in: PubMed
  50. Bach EA, Szabo SJ, Dighe AS, Ashkenazi A, Aguet M, Murphy KM, Schreiber RD. Ligand-induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell subsets. Science. 1995 Nov 17; 270(5239):1215-8. PMID: 7502050.
    View in: PubMed
  51. Dighe AS, Campbell D, Hsieh CS, Clarke S, Greaves DR, Gordon S, Murphy KM, Schreiber RD. Tissue-specific targeting of cytokine unresponsiveness in transgenic mice. Immunity. 1995 Nov; 3(5):657-66. PMID: 7584155.
    View in: PubMed
  52. Szabo SJ, Jacobson NG, Dighe AS, Gubler U, Murphy KM. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity. 1995 Jun; 2(6):665-75. PMID: 7796298.
    View in: PubMed
  53. Dighe AS, Richards E, Old LJ, Schreiber RD. Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFN gamma receptors. Immunity. 1994 Sep; 1(6):447-56. PMID: 7895156.
    View in: PubMed
  54. Dighe AS, Farrar MA, Schreiber RD. Inhibition of cellular responsiveness to interferon-gamma (IFN gamma) induced by overexpression of inactive forms of the IFN gamma receptor. J Biol Chem. 1993 May 15; 268(14):10645-53. PMID: 8387525.
    View in: PubMed
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