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Masao Kaneki, PH.D., M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM117298 (KANEKI, MASAO) Sep 23, 2016 - Aug 31, 2020
    NIH/NIGMS
    Impairment of Directional Neutrophil Migration and Farnesylation in Sepsis
    Role: Principal Investigator
  2. R01GM115552 (KANEKI, MASAO) Jun 1, 2016 - May 31, 2020
    NIH/NIGMS
    Targeting Warburg Effect to Reverse Stress-Induced Insulin Resistance in Burns
    Role: Principal Investigator
  3. R01DK058127 (KANEKI, MASAO) Jul 1, 2002 - Aug 31, 2010
    NIH/NIDDK
    Inducible nitric oxide synthase and insulin resistance
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sasaki M, Shinozaki S, Morinaga H, Kaneki M, Nishimura E, Shimokado K. iNOS inhibits hair regeneration in obese diabetic (ob/ob) mice. Biochem Biophys Res Commun. 2018 Jul 02; 501(4):893-897. PMID: 29763605.
    View in: PubMed
  2. Kaneki M. Metabolic Inflammatory Complex in Sepsis: Septic Cachexia as a Novel Potential Therapeutic Target. Shock. 2017 Dec; 48(6):600-609. PMID: 28520694.
    View in: PubMed
  3. Tanaka T, Nakazawa H, Kuriyama N, Kaneki M. Farnesyltransferase inhibitors prevent HIV protease inhibitor (lopinavir/ritonavir)-induced lipodystrophy and metabolic syndrome in mice. Exp Ther Med. 2018 Feb; 15(2):1314-1320. PMID: 29434718.
    View in: PubMed
  4. Wakiyama K, Kitajima Y, Tanaka T, Kaneki M, Yanagihara K, Aishima S, Nakamura J, Noshiro H. Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis. Sci Rep. 2017 Oct 04; 7(1):12653. PMID: 28978999.
    View in: PubMed
  5. Kaneki M. What's New in SHOCK October 2017? Shock. 2017 Oct; 48(4):387-389. PMID: 28915213.
    View in: PubMed
  6. Khan MAS, Khan MF, Kashiwagi S, Kem WR, Yasuhara S, Kaneki M, Tompkins RG, Martyn JAJ. An ALPHA7 Nicotinic Acetylcholine Receptor Agonist (GTS-21) Promotes C2C12 Myonuclear Accretion in Association with Release of Interleukin-6 (IL-6) and Improves Survival in Burned Mice. Shock. 2017 Aug; 48(2):227-235. PMID: 28282360.
    View in: PubMed
  7. Nakazawa H, Ikeda K, Shinozaki S, Kobayashi M, Ikegami Y, Fu M, Nakamura T, Yasuhara S, Yu YM, Martyn JAJ, Tompkins RG, Shimokado K, Yorozu T, Ito H, Inoue S, Kaneki M. Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1a and mTORC1: Role of protein farnesylation. Sci Rep. 2017 Jul 26; 7(1):6618. PMID: 28747716.
    View in: PubMed
  8. Nakazawa H, Chang K, Shinozaki S, Yasukawa T, Ishimaru K, Yasuhara S, Yu YM, Martyn JA, Tompkins RG, Shimokado K, Kaneki M. iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-?B and p53. PLoS One. 2017; 12(1):e0170391. PMID: 28099528.
    View in: PubMed
  9. Kashiwagi S, Khan MA, Yasuhara S, Goto T, Kem WR, Tompkins RG, Kaneki M, Martyn JA. Prevention of Burn-Induced Inflammatory Responses and Muscle Wasting by GTS-21, a Specific Agonist for a7 Nicotinic Acetylcholine Receptors. Shock. 2017 01; 47(1):61-69. PMID: 27529131.
    View in: PubMed
  10. Ueki R, Liu L, Kashiwagi S, Kaneki M, Khan MA, Hirose M, Tompkins RG, Martyn JA, Yasuhara S. Role of Elevated Fibrinogen in Burn-Induced Mitochondrial Dysfunction: Protective Effects of Glycyrrhizin. Shock. 2016 10; 46(4):382-9. PMID: 27172157.
    View in: PubMed
  11. Shimomura Y, Suga M, Kuriyama N, Nakamura T, Sakai T, Kato Y, Hara Y, Yamashita C, Nagasaki H, Kaneki M, Nishida O. Recombinant human thrombomodulin inhibits neutrophil extracellular trap formation in vitro. J Intensive Care. 2016; 4:48. PMID: 27453785; PMCID: PMC4957921.
  12. Peng M, Zhang C, Dong Y, Zhang Y, Nakazawa H, Kaneki M, Zheng H, Shen Y, Marcantonio ER, Xie Z. Battery of behavioral tests in mice to study postoperative delirium. Sci Rep. 2016 07 20; 6:29874. PMID: 27435513.
    View in: PubMed
  13. Tanaka T, Ikegami Y, Nakazawa H, Kuriyama N, Oki M, Hanai J, Sukhatme VP, Kaneki M. Low-Dose Farnesyltransferase Inhibitor Suppresses HIF-1a and Snail Expression in Triple-Negative Breast Cancer MDA-MB-231 Cells In Vitro. J Cell Physiol. 2017 Jan; 232(1):192-201. PMID: 27137755.
    View in: PubMed
  14. Jones CN, Hoang AN, Martel JM, Dimisko L, Mikkola A, Inoue Y, Kuriyama N, Yamada M, Hamza B, Kaneki M, Warren HS, Brown DE, Irimia D. Microfluidic assay for precise measurements of mouse, rat, and human neutrophil chemotaxis in whole-blood droplets. J Leukoc Biol. 2016 07; 100(1):241-7. PMID: 26819316.
    View in: PubMed
  15. Marutani E, Yamada M, Ida T, Tokuda K, Ikeda K, Kai S, Shirozu K, Hayashida K, Kosugi S, Hanaoka K, Kaneki M, Akaike T, Ichinose F. Thiosulfate Mediates Cytoprotective Effects of Hydrogen Sulfide Against Neuronal Ischemia. J Am Heart Assoc. 2015 Nov 06; 4(11). PMID: 26546573; PMCID: PMC4845224.
  16. Quraishi SA, De Pascale G, Needleman JS, Nakazawa H, Kaneki M, Bajwa EK, Camargo CA, Bhan I. Effect of Cholecalciferol Supplementation on Vitamin D Status and Cathelicidin Levels in Sepsis: A Randomized, Placebo-Controlled Trial. Crit Care Med. 2015 Sep; 43(9):1928-37. PMID: 26086941; PMCID: PMC4537665.
  17. Yamada Y, Eto M, Ito Y, Mochizuki S, Son BK, Ogawa S, Iijima K, Kaneki M, Kozaki K, Toba K, Akishita M, Ouchi Y. Suppressive Role of PPAR?-Regulated Endothelial Nitric Oxide Synthase in Adipocyte Lipolysis. PLoS One. 2015; 10(8):e0136597. PMID: 26317347; PMCID: PMC4552558.
  18. Irie T, Sips PY, Kai S, Kida K, Ikeda K, Hirai S, Moazzami K, Jiramongkolchai P, Bloch DB, Doulias PT, Armoundas AA, Kaneki M, Ischiropoulos H, Kranias E, Bloch KD, Stamler JS, Ichinose F. S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy. Circ Res. 2015 Oct 09; 117(9):793-803. PMID: 26259881; PMCID: PMC4600453 [Available on 10/09/16].
  19. Tsuzuki T, Shinozaki S, Nakamoto H, Kaneki M, Goto S, Shimokado K, Kobayashi H, Naito H. Voluntary Exercise Can Ameliorate Insulin Resistance by Reducing iNOS-Mediated S-Nitrosylation of Akt in the Liver in Obese Rats. PLoS One. 2015; 10(7):e0132029. PMID: 26172834; PMCID: PMC4501761.
  20. Kashiwagi A, Hosokawa S, Maeyama Y, Ueki R, Kaneki M, Martyn JA, Yasuhara S. Anesthesia with Disuse Leads to Autophagy Up-regulation in the Skeletal Muscle. Anesthesiology. 2015 May; 122(5):1075-83. PMID: 25501690; PMCID: PMC4439320.
  21. Zhao G, Yu YM, Kaneki M, Bonab AA, Tompkins RG, Fischman AJ. Simvastatin reduces burn injury-induced splenic apoptosis via downregulation of the TNF-a/NF-?B pathway. Ann Surg. 2015 May; 261(5):1006-12. PMID: 24950285; PMCID: PMC4272342.
  22. Nakazawa H, Yamada M, Tanaka T, Kramer J, Yu YM, Fischman AJ, Martyn JA, Tompkins RG, Kaneki M. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS One. 2015; 10(1):e0116633. PMID: 25594415; PMCID: PMC4296934.
  23. Shirozu K, Hirai S, Tanaka T, Hisaka S, Kaneki M, Ichinose F. Farnesyltransferase inhibitor, tipifarnib, prevents galactosamine/lipopolysaccharide-induced acute liver failure. Shock. 2014 Dec; 42(6):570-577. PMID: 25046541; PMCID: PMC4236263.
  24. Shinozaki S, Chang K, Sakai M, Shimizu N, Yamada M, Tanaka T, Nakazawa H, Ichinose F, Yamada Y, Ishigami A, Ito H, Ouchi Y, Starr ME, Saito H, Shimokado K, Stamler JS, Kaneki M. Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65. Sci Signal. 2014 Nov 11; 7(351):ra106. PMID: 25389371; PMCID: PMC4340581.
  25. Lee S, Yang HS, Sasakawa T, Khan MA, Khatri A, Kaneki M, Martyn JA. Immobilization with atrophy induces de novo expression of neuronal nicotinic a7 acetylcholine receptors in muscle contributing to neurotransmission. Anesthesiology. 2014 Jan; 120(1):76-85. PMID: 24126263; PMCID: PMC3910258.
  26. Fukaya M, Tamura Y, Chiba Y, Tanioka T, Mao J, Inoue Y, Yamada M, Waeber C, Ido-Kitamura Y, Kitamura T, Kaneki M. Protective effects of a nicotinamide derivative, isonicotinamide, against streptozotocin-induced ß-cell damage and diabetes in mice. Biochem Biophys Res Commun. 2013 Dec 06; 442(1-2):92-8. PMID: 24246675; PMCID: PMC4084867.
  27. Khan MA, Sahani N, Neville KA, Nagashima M, Lee S, Sasakawa T, Kaneki M, Martyn JA. Nonsurgically induced disuse muscle atrophy and neuromuscular dysfunction upregulates alpha7 acetylcholine receptors. Can J Physiol Pharmacol. 2014 Jan; 92(1):1-8. PMID: 24383867; PMCID: PMC4086193.
  28. Zhao G, Yu YM, Kaneki M, Tompkins RG, Fischman AJ. Simvastatin protects hepatocytes from apoptosis by suppressing the TNF-a/caspase-3 signaling pathway in mice with burn injury. Ann Surg. 2013 Jun; 257(6):1129-36. PMID: 23275311; PMCID: PMC4102342.
  29. Coppadoro A, Berra L, Kumar A, Pinciroli R, Yamada M, Schmidt UH, Bittner EA, Kaneki M. Critical illness is associated with decreased plasma levels of coenzyme Q10: a cross-sectional study. J Crit Care. 2013 Oct; 28(5):571-6. PMID: 23618779; PMCID: PMC4073588.
  30. Hosokawa S, Koseki H, Nagashima M, Maeyama Y, Yomogida K, Mehr C, Rutledge M, Greenfeld H, Kaneki M, Tompkins RG, Martyn JA, Yasuhara SE. Title efficacy of phosphodiesterase 5 inhibitor on distant burn-induced muscle autophagy, microcirculation, and survival rate. Am J Physiol Endocrinol Metab. 2013 May 01; 304(9):E922-33. PMID: 23512808.
    View in: PubMed
  31. Sips PY, Irie T, Zou L, Shinozaki S, Sakai M, Shimizu N, Nguyen R, Stamler JS, Chao W, Kaneki M, Ichinose F. Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression. Am J Physiol Heart Circ Physiol. 2013 Apr 15; 304(8):H1134-46. PMID: 23417863; PMCID: PMC3625910.
  32. Zhu S, Nagashima M, Khan MA, Yasuhara S, Kaneki M, Martyn JA. Lack of caspase-3 attenuates immobilization-induced muscle atrophy and loss of tension generation along with mitigation of apoptosis and inflammation. Muscle Nerve. 2013 May; 47(5):711-21. PMID: 23401051; PMCID: PMC3634903.
  33. Yasuda Y, Fukushima Y, Kaneki M, Martyn JA. Anesthesia with propofol induces insulin resistance systemically in skeletal and cardiac muscles and liver of rats. Biochem Biophys Res Commun. 2013 Feb 01; 431(1):81-5. PMID: 23274498; PMCID: PMC3566703.
  34. Kaneki M, Fukushima Y, Shinozaki S, Fukaya M, Habiro M, Shimizu N, Chang K, Yasuhara S, Martyn JA. iNOS inhibitor, L-NIL, reverses burn-induced glycogen synthase kinase-3ß activation in skeletal muscle of rats. Metabolism. 2013 Mar; 62(3):341-6. PMID: 22995863; PMCID: PMC4090935.
  35. Khan MA, Farkhondeh M, Crombie J, Jacobson L, Kaneki M, Martyn JA. Lipopolysaccharide upregulates a7 acetylcholine receptors: stimulation with GTS-21 mitigates growth arrest of macrophages and improves survival in burned mice. Shock. 2012 Aug; 38(2):213-9. PMID: 22683726; PMCID: PMC3399057.
  36. Lee HY, Kaneki M, Andreas J, Tompkins RG, Martyn JA. Novel mitochondria-targeted antioxidant peptide ameliorates burn-induced apoptosis and endoplasmic reticulum stress in the skeletal muscle of mice. Shock. 2011 Dec; 36(6):580-5. PMID: 21937949; PMCID: PMC3230221.
  37. Tamura Y, Chiba Y, Tanioka T, Shimizu N, Shinozaki S, Yamada M, Kaneki K, Mori S, Araki A, Ito H, Kaneki M. NO donor induces Nec-1-inhibitable, but RIP1-independent, necrotic cell death in pancreatic ß-cells. FEBS Lett. 2011 Oct 03; 585(19):3058-64. PMID: 21888904; PMCID: PMC3304503.
  38. Yang W, Yamada M, Tamura Y, Chang K, Mao J, Zou L, Feng Y, Kida K, Scherrer-Crosbie M, Chao W, Ichinose F, Yu YM, Fischman AJ, Tompkins RG, Yao S, Kaneki M. Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance. J Pharmacol Exp Ther. 2011 Dec; 339(3):832-41. PMID: 21873557; PMCID: PMC3226365.
  39. Shinozaki S, Choi CS, Shimizu N, Yamada M, Kim M, Zhang T, Shiota G, Dong HH, Kim YB, Kaneki M. Liver-specific inducible nitric-oxide synthase expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice. J Biol Chem. 2011 Oct 07; 286(40):34959-75. PMID: 21846719; PMCID: PMC3186386.
  40. Sugita M, Sugita H, Kim M, Mao J, Yasuda Y, Habiro M, Shinozaki S, Yasuhara S, Shimizu N, Martyn JA, Kaneki M. Inducible nitric oxide synthase deficiency ameliorates skeletal muscle insulin resistance but does not alter unexpected lower blood glucose levels after burn injury in C57BL/6 mice. Metabolism. 2012 Jan; 61(1):127-36. PMID: 21816442; PMCID: PMC3304504.
  41. Tanioka T, Tamura Y, Fukaya M, Shinozaki S, Mao J, Kim M, Shimizu N, Kitamura T, Kaneki M. Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta. J Biol Chem. 2011 Aug 19; 286(33):29388-96. PMID: 21700708; PMCID: PMC3190744.
  42. Kakinohana M, Kida K, Minamishima S, Atochin DN, Huang PL, Kaneki M, Ichinose F. Delayed paraplegia after spinal cord ischemic injury requires caspase-3 activation in mice. Stroke. 2011 Aug; 42(8):2302-7. PMID: 21700940; PMCID: PMC3199137.
  43. Kida K, Yamada M, Tokuda K, Marutani E, Kakinohana M, Kaneki M, Ichinose F. Inhaled hydrogen sulfide prevents neurodegeneration and movement disorder in a mouse model of Parkinson's disease. Antioxid Redox Signal. 2011 Jul 15; 15(2):343-52. PMID: 21050138; PMCID: PMC3118610.
  44. Tamura Y, Watanabe K, Kantani T, Hayashi J, Ishida N, Kaneki M. Upregulation of circulating IL-15 by treadmill running in healthy individuals: is IL-15 an endocrine mediator of the beneficial effects of endurance exercise? Endocr J. 2011; 58(3):211-5. PMID: 21307608.
    View in: PubMed
  45. Beffa DC, Fischman AJ, Fagan SP, Hamrahi VF, Paul KW, Kaneki M, Yu YM, Tompkins RG, Carter EA. Simvastatin treatment improves survival in a murine model of burn sepsis: Role of interleukin 6. Burns. 2011 Mar; 37(2):222-6. PMID: 21145172; PMCID: PMC4085785.
  46. Yamada M, Kida K, Amutuhaire W, Ichinose F, Kaneki M. Gene disruption of caspase-3 prevents MPTP-induced Parkinson's disease in mice. Biochem Biophys Res Commun. 2010 Nov 12; 402(2):312-8. PMID: 20937256; PMCID: PMC3292898.
  47. Bonab AA, Carter EA, Paul K, Kaneki M, Yu YM, Tompkins RG, Fischman AJ. Effect of simvastatin on burn-induced alterations in tissue specific glucose metabolism: implications for burn associated insulin resistance. Int J Mol Med. 2010 Sep; 26(3):311-6. PMID: 20664945; PMCID: PMC4090513.
  48. Sugita H, Kaneki M, Furuhashi S, Hirota M, Takamori H, Baba H. Nitric oxide inhibits the proliferation and invasion of pancreatic cancer cells through degradation of insulin receptor substrate-1 protein. Mol Cancer Res. 2010 Aug; 8(8):1152-63. PMID: 20663861.
    View in: PubMed
  49. Shinozaki S, Inoue Y, Yang W, Fukaya M, Carter EA, Yu YM, Ming-Yu Y, Fischman A, Tompkins R, Kaneki M. Farnesyltransferase inhibitor improved survival following endotoxin challenge in mice. Biochem Biophys Res Commun. 2010 Jan 15; 391(3):1459-64. PMID: 20034462; PMCID: PMC2813732.
  50. Kaneki M, Shinozaki S, Chang K, Shimizu N. Could insulin sensitization be used as an alternative to intensive insulin therapy to improve the survival of intensive care unit patients with stress-induced hyperglycemia? Crit Care Med. 2009 Oct; 37(10):2856-8. PMID: 19865018.
    View in: PubMed
  51. Kaneki M. [Is ucOC a novel bone-derived anti-diabetogenic hormone in humans?]. Clin Calcium. 2009 Sep; 19(9):1304-10. PMID: 19721202.
    View in: PubMed
  52. Kaneki M, Sakai M, Shimizu N, Chang K. Is normalized mean blood glucose level good enough for the intensive care unit?--glycemic variability as a new independent predictor of mortality. Crit Care Med. 2008 Nov; 36(11):3104-6. PMID: 18941315.
    View in: PubMed
  53. Raher MJ, Thibault HB, Buys ES, Kuruppu D, Shimizu N, Brownell AL, Blake SL, Rieusset J, Kaneki M, Derumeaux G, Picard MH, Bloch KD, Scherrer-Crosbie M. A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overload. Am J Physiol Heart Circ Physiol. 2008 Dec; 295(6):H2495-502. PMID: 18978196; PMCID: PMC2614531.
  54. Martyn JA, Kaneki M, Yasuhara S. Obesity-induced insulin resistance and hyperglycemia: etiologic factors and molecular mechanisms. Anesthesiology. 2008 Jul; 109(1):137-48. PMID: 18580184; PMCID: PMC3896971.
  55. Kaneki M. [Genomic approaches to bone and joint diseases. New insights into molecular mechanisms underlying protective effects of vitamin K on bone health]. Clin Calcium. 2008 Feb; 18(2):224-32. PMID: 18245893.
    View in: PubMed
  56. Asai A, Sahani N, Kaneki M, Ouchi Y, Martyn JA, Yasuhara SE. Primary role of functional ischemia, quantitative evidence for the two-hit mechanism, and phosphodiesterase-5 inhibitor therapy in mouse muscular dystrophy. PLoS One. 2007 Aug 29; 2(8):e806. PMID: 17726536; PMCID: PMC1950086.
  57. Ota H, Akishita M, Eto M, Iijima K, Kaneki M, Ouchi Y. Sirt1 modulates premature senescence-like phenotype in human endothelial cells. J Mol Cell Cardiol. 2007 Nov; 43(5):571-9. PMID: 17916362.
    View in: PubMed
  58. Frick CG, Richtsfeld M, Sahani ND, Kaneki M, Blobner M, Martyn JA. Long-term effects of botulinum toxin on neuromuscular function. Anesthesiology. 2007 Jun; 106(6):1139-46. PMID: 17525589.
    View in: PubMed
  59. Sugita M, Sugita H, Kaneki M. Farnesyltransferase inhibitor, manumycin a, prevents atherosclerosis development and reduces oxidative stress in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1390-5. PMID: 17363690.
    View in: PubMed
  60. Kaneki M, Shimizu N, Yamada D, Chang K. Nitrosative stress and pathogenesis of insulin resistance. Antioxid Redox Signal. 2007 Mar; 9(3):319-29. PMID: 17184170.
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  61. Ichinose F, Buys ES, Neilan TG, Furutani EM, Morgan JG, Jassal DS, Graveline AR, Searles RJ, Lim CC, Kaneki M, Picard MH, Scherrer-Crosbie M, Janssens S, Liao R, Bloch KD. Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock. Circ Res. 2007 Jan 05; 100(1):130-9. PMID: 17138944.
    View in: PubMed
  62. Kaneki M. [Protective effects of vitamin K against osteoporosis and its pleiotropic actions]. Clin Calcium. 2006 Sep; 16(9):1526-34. PMID: 16951479.
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  63. Kaneki M, Hosoi T, Ouchi Y, Orimo H. Pleiotropic actions of vitamin K: protector of bone health and beyond? Nutrition. 2006 Jul-Aug; 22(7-8):845-52. PMID: 16815498.
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  64. Yasuhara S, Kaneki M, Sugita H, Sugita M, Asai A, Sahani N, Chon JY, Tompkins RG, Martyn JA. Adipocyte apoptosis after burn injury is associated with altered fat metabolism. J Burn Care Res. 2006 May-Jun; 27(3):367-76. PMID: 16679908.
    View in: PubMed
  65. Ota H, Tokunaga E, Chang K, Hikasa M, Iijima K, Eto M, Kozaki K, Akishita M, Ouchi Y, Kaneki M. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene. 2006 Jan 12; 25(2):176-85. PMID: 16170353.
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  66. Fujimoto M, Shimizu N, Kunii K, Martyn JA, Ueki K, Kaneki M. A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice. Diabetes. 2005 May; 54(5):1340-8. PMID: 15855318.
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  67. Kaneki M. [Vitamin K2 as a protector of bone health and beyond]. Clin Calcium. 2005 Apr; 15(4):605-10. PMID: 15802772.
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  68. Sugita H, Fujimoto M, Yasukawa T, Shimizu N, Sugita M, Yasuhara S, Martyn JA, Kaneki M. Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells. J Biol Chem. 2005 Apr 08; 280(14):14203-11. PMID: 15805118.
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  69. Yasukawa T, Tokunaga E, Ota H, Sugita H, Martyn JA, Kaneki M. S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance. J Biol Chem. 2005 Mar 04; 280(9):7511-8. PMID: 15632167.
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  70. Sugita H, Kaneki M, Sugita M, Yasukawa T, Yasuhara S, Martyn JA. Burn injury impairs insulin-stimulated Akt/PKB activation in skeletal muscle. Am J Physiol Endocrinol Metab. 2005 Mar; 288(3):E585-91. PMID: 15536206.
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  71. Sugita M, Sugita H, Kaneki M. Increased insulin receptor substrate 1 serine phosphorylation and stress-activated protein kinase/c-Jun N-terminal kinase activation associated with vascular insulin resistance in spontaneously hypertensive rats. Hypertension. 2004 Oct; 44(4):484-9. PMID: 15302844.
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  72. Yasukawa T, Kaneki M, Yasuhara S, Lee SL, Martyn JA. Steroidal nondepolarizing muscle relaxants do not simulate the effects of glucocorticoids on glucocorticoid receptor-mediated transcription in cultured skeletal muscle cells. Anesthesiology. 2004 Jun; 100(6):1615-9. PMID: 15166588.
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  73. Yasuhara S, Zhu Y, Matsui T, Tipirneni N, Yasuhara Y, Kaneki M, Rosenzweig A, Martyn JA. Comparison of comet assay, electron microscopy, and flow cytometry for detection of apoptosis. J Histochem Cytochem. 2003 Jul; 51(7):873-85. PMID: 12810838.
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  74. Sugita H, Kaneki M, Tokunaga E, Sugita M, Koike C, Yasuhara S, Tompkins RG, Martyn JA. Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance. Am J Physiol Endocrinol Metab. 2002 Feb; 282(2):E386-94. PMID: 11788371.
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  75. Kaneki M, Hodges SJ, Hedges SJ, Hosoi T, Fujiwara S, Lyons A, Crean SJ, Ishida N, Nakagawa M, Takechi M, Sano Y, Mizuno Y, Hoshino S, Miyao M, Inoue S, Horiki K, Shiraki M, Ouchi Y, Orimo H. Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk. Nutrition. 2001 Apr; 17(4):315-21. PMID: 11369171.
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  76. Hirose M, Kaneki M, Sugita H, Yasuhara S, Ibebunjo C, Martyn JA, Iebunjo C. Long-term denervation impairs insulin receptor substrate-1-mediated insulin signaling in skeletal muscle. Metabolism. 2001 Feb; 50(2):216-22. PMID: 11229432.
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  77. Datta R, Yoshinaga K, Kaneki M, Pandey P, Kufe D. Phorbol ester-induced generation of reactive oxygen species is protein kinase cbeta -dependent and required for SAPK activation. J Biol Chem. 2000 Dec 29; 275(52):41000-3. PMID: 11042219.
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  78. Hirose M, Kaneki M, Sugita H, Yasuhara S, Martyn JA. Immobilization depresses insulin signaling in skeletal muscle. Am J Physiol Endocrinol Metab. 2000 Dec; 279(6):E1235-41. PMID: 11093909.
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  79. Yasuhara S, Perez ME, Kanakubo E, Yasuhara Y, Shin YS, Kaneki M, Fujita T, Martyn JA. Skeletal muscle apoptosis after burns is associated with activation of proapoptotic signals. Am J Physiol Endocrinol Metab. 2000 Nov; 279(5):E1114-21. PMID: 11052967.
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  80. Kharbanda S, Pandey P, Yamauchi T, Kumar S, Kaneki M, Kumar V, Bharti A, Yuan ZM, Ghanem L, Rana A, Weichselbaum R, Johnson G, Kufe D. Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage. Mol Cell Biol. 2000 Jul; 20(14):4979-89. PMID: 10866655.
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  81. Kharbanda S, Saxena S, Yoshida K, Pandey P, Kaneki M, Wang Q, Cheng K, Chen YN, Campbell A, Sudha T, Yuan ZM, Narula J, Weichselbaum R, Nalin C, Kufe D. Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage. J Biol Chem. 2000 Jan 07; 275(1):322-7. PMID: 10617621.
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  82. Kaneki M. [Insulin receptor and aging]. Nihon Ronen Igakkai Zasshi. 1999 Dec; 36(12):844-50. PMID: 10689893.
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  83. Yasuhara S, Kanakubo E, Perez ME, Kaneki M, Fujita T, Okamoto T, Martyn JA. The 1999 Moyer award. Burn injury induces skeletal muscle apoptosis and the activation of caspase pathways in rats. J Burn Care Rehabil. 1999 Nov-Dec; 20(6):462-70. PMID: 10613683.
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  84. Kaneki M, Kharbanda S, Pandey P, Yoshida K, Takekawa M, Liou JR, Stone R, Kufe D. Functional role for protein kinase Cbeta as a regulator of stress-activated protein kinase activation and monocytic differentiation of myeloid leukemia cells. Mol Cell Biol. 1999 Jan; 19(1):461-70. PMID: 9858570.
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  85. Ishikawa S, Otsuki T, Kaneki M, Jokura H, Yoshimoto T. Dose-related effects of single focal irradiation in the medial temporal lobe structures in rats--magnetic resonance imaging and histological study. Neurol Med Chir (Tokyo). 1999 Jan; 39(1):1-7. PMID: 10093454.
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  86. Shiraki M, Shiraki Y, Aoki C, Hosoi T, Inoue S, Kaneki M, Ouchi Y. Association of bone mineral density with apolipoprotein E phenotype. J Bone Miner Res. 1997 Sep; 12(9):1438-45. PMID: 9286760.
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  87. Pandey P, Raingeaud J, Kaneki M, Weichselbaum R, Davis RJ, Kufe D, Kharbanda S. Activation of p38 mitogen-activated protein kinase by c-Abl-dependent and -independent mechanisms. J Biol Chem. 1996 Sep 27; 271(39):23775-9. PMID: 8798604.
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  88. Hoshino S, Inoue S, Hosoi T, Saito T, Ikegami A, Kaneki M, Ouchi Y, Orimo H. Demonstration of isoforms of the estrogen receptor in the bone tissues and in osteoblastic cells. Calcif Tissue Int. 1995 Dec; 57(6):466-8. PMID: 8581881.
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  89. Kaneki M, Mizuno Y, Hosoi T, Inoue S, Hoshino S, Akishita M, Akedo Y, Horiki K, Nakamura T, Shiraki M, et al. [Serum concentration of vitamin K in elderly women with involutional osteoporosis]. Nihon Ronen Igakkai Zasshi. 1995 Mar; 32(3):195-200. PMID: 7596062.
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  90. Ikegami A, Inoue S, Hosoi T, Kaneki M, Mizuno Y, Akedo Y, Ouchi Y, Orimo H. Cell cycle-dependent expression of estrogen receptor and effect of estrogen on proliferation of synchronized human osteoblast-like osteosarcoma cells. Endocrinology. 1994 Aug; 135(2):782-9. PMID: 8033827.
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  91. Kaneki M, Inoue S, Hosoi T, Mizuno Y, Akedo Y, Ikegami A, Nakamura T, Shiraki M, Ito H, Suzu S, et al. Effects of 1 alpha,25-dihydroxyvitamin D3 on macrophage colony-stimulating factor production and proliferation of human monocytic cells. Blood. 1994 Apr 15; 83(8):2285-93. PMID: 8161795.
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  92. Mizuno Y, Hosoi T, Inoue S, Ikegami A, Kaneki M, Akedo Y, Nakamura T, Ouchi Y, Chang C, Orimo H. Immunocytochemical identification of androgen receptor in mouse osteoclast-like multinucleated cells. Calcif Tissue Int. 1994 Apr; 54(4):325-6. PMID: 8062148.
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  93. Akedo Y, Hosoi T, Inoue S, Ikegami A, Mizuno Y, Kaneki M, Nakamura T, Ouchi Y, Orimo H. Vitamin K2 modulates proliferation and function of osteoblastic cells in vitro. Biochem Biophys Res Commun. 1992 Sep 16; 187(2):814-20. PMID: 1530637.
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  94. Shiraki M, Inoue J, Kaneki M, Seimiya Y, Chen JT, Hasumi K, Masubuchi K. [Time course changes in bone mineral density and calcium metabolism after oophorectomy]. Nihon Sanka Fujinka Gakkai Zasshi. 1992 Feb; 44(2):145-52. PMID: 1545168.
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  95. Li NH, Ouchi Y, Okamoto Y, Masuyama A, Kaneki M, Futami A, Hosoi T, Nakamura T, Orimo H. Effect of parathyroid hormone on release of interleukin 1 and interleukin 6 from cultured mouse osteoblastic cells. Biochem Biophys Res Commun. 1991 Aug 30; 179(1):236-42. PMID: 1883354.
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  96. Sato F, Okamoto Y, Ouchi Y, Kaneki M, Nakamura T, Ikekawa N, Orimo H. Biological activity of 1 alpha, 25-dihydroxyvitamin D derivatives--24-epi-1 alpha, 25-dihydroxyvitamin D-2 and 1 alpha,25-dihydroxyvitamin D-7. Biochim Biophys Acta. 1991 Jan 31; 1091(2):188-92. PMID: 1995078.
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  97. Sato F, Ouchi Y, Okamoto Y, Kaneki M, Nakamura T, Ikekawa N, Orimo H. Effects of vitamin D2 analogs on calcium metabolism in vitamin D-deficient rats and in MC3T3-E1 osteoblastic cells. Res Exp Med (Berl). 1991; 191(4):235-42. PMID: 1788469.
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  98. Orimo H, Kaneki M. [Etiology and risk factors of involutional osteoporosis]. Nihon Rinsho. 1990 Dec; 48(12):2862-6. PMID: 2086846.
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  99. Shiraki M, Kaneki M. [Prostaglandins]. Nihon Rinsho. 1990 Dec; 48(12):2811-7. PMID: 2086838.
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