Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Roy Howard Perlis, M.D.

Title
Institution
Department
Address
Phone
Fax

Overview
Director, Pharmacogenomics Research, Department of Psychiatry and Center for Human Genetic Research, Massachusetts General Hospital
Medical Director, Bipolar Clinic and Research Program, Massachusetts General Hospital

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01MH116270 (PERLIS, ROY H.) Jan 1, 2019 - Nov 30, 2022
    NIH/NIMH
    1/2 Leveraging electronic health records for pharmacogenomics of psychiatric disorders
    Role: Principal Investigator
  2. R56MH115187 (PERLIS, ROY H) Aug 10, 2018 - Aug 9, 2019
    NIH/NIMH
    Machine learning for data-driven subtyping of major depression
    Role: Principal Investigator
  3. R01MH106577 (PERLIS, ROY H) Apr 6, 2016 - Feb 28, 2019
    NIH/NIMH
    Natural language processing for characterizing psychopathology
    Role: Principal Investigator
  4. R01AT009144 (PERLIS, ROY H.) Sep 30, 2015 - Sep 29, 2020
    NIH/NCCIH
    Patient-Derived Cellular Models of Putative Antidepressants
    Role: Co-Principal Investigator
  5. R01HL124262 (PERLIS, ROY H.) Apr 1, 2015 - Mar 31, 2019
    NIH/NHLBI
    Genetics of Cardiotoxic Drug Response to Psychiatric Therapy
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sellgren CM, Gracias J, Watmuff B, Biag JD, Thanos JM, Whittredge PB, Fu T, Worringer K, Brown HE, Wang J, Kaykas A, Karmacharya R, Goold CP, Sheridan SD, Perlis RH. Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning. Nat Neurosci. 2019 Feb 04. PMID: 30718903.
    Citations:    
  2. McCoy TH, Pellegrini AM, Perlis RH. Research Domain Criteria scores estimated through natural language processing are associated with risk for suicide and accidental death. Depress Anxiety. 2019 Feb 02. PMID: 30710497.
    Citations:    
  3. Sellgren CM, Gracias J, Jungholm O, Perlis RH, Engberg G, Schwieler L, Landen M, Erhardt S. Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls. Transl Psychiatry. 2019 Jan 29; 9(1):37. PMID: 30696814.
    Citations:    Fields:    
  4. McCoy TH, Pellegrini AM, Perlis RH. Using phenome-wide association to investigate the function of a schizophrenia risk locus at SLC39A8. Transl Psychiatry. 2019 Jan 29; 9(1):45. PMID: 30696806.
    Citations:    Fields:    
  5. Hart KL, Brown HE, Roffman JL, Perlis RH. Risk tolerance measured by probability discounting among individuals with primary mood and psychotic disorders. Neuropsychology. 2019 Jan 28. PMID: 30688494.
    Citations:    Fields:    
  6. Shao Z, Noh H, Bin Kim W, Ni P, Nguyen C, Cote SE, Noyes E, Zhao J, Parsons T, Park JM, Zheng K, Park JJ, Coyle JT, Weinberger DR, Straub RE, Berman KF, Apud J, Ongur D, Cohen BM, McPhie DL, Rapoport JL, Perlis RH, Lanz TA, Xi HS, Yin C, Huang W, Hirayama T, Fukuda E, Yagi T, Ghosh S, Eggan KC, Kim HY, Eisenberg LM, Moghadam AA, Stanton PK, Cho JH, Chung S. Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia. Nat Neurosci. 2019 Feb; 22(2):229-242. PMID: 30664768.
    Citations:    Fields:    
  7. Charney AW, Stahl EA, Green EK, Chen CY, Moran JL, Chambert K, Belliveau RA, Forty L, Gordon-Smith K, Lee PH, Bromet EJ, Buckley PF, Escamilla MA, Fanous AH, Fochtmann LJ, Lehrer DS, Malaspina D, Marder SR, Morley CP, Nicolini H, Perkins DO, Rakofsky JJ, Rapaport MH, Medeiros H, Sobell JL, Backlund L, Bergen SE, Juréus A, Schalling M, Lichtenstein P, Knowles JA, Burdick KE, Jones I, Jones LA, Hultman CM, Perlis R, Purcell SM, McCarroll SA, Pato CN, Pato MT, Di Florio A, Craddock N, Landén M, Smoller JW, Ruderfer DM, Sklar P. Contribution of Rare Copy Number Variants to Bipolar Disorder Risk Is Limited to Schizoaffective Cases. Biol Psychiatry. 2018 Dec 20. PMID: 30686506.
    Citations:    Fields:    
  8. Gilbert TM, Zürcher NR, Wu CJ, Bhanot A, Hightower BG, Kim M, Albrecht DS, Wey HY, Schroeder FA, Rodriguez-Thompson A, Morin TM, Hart KL, Pellegrini AM, Riley MM, Wang C, Stufflebeam SM, Haggarty SJ, Holt DJ, Loggia ML, Perlis RH, Brown HE, Roffman JL, Hooker JM. PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia. J Clin Invest. 2019 Jan 02; 129(1):364-372. PMID: 30530989.
    Citations:    Fields:    
  9. Rivara FP, Fihn SD, Perlis RH. Advancing Health and Health Care Using Machine Learning: JAMA Network Open Call for Papers. JAMA Netw Open. 2018 Dec 07; 1(8):e187176. PMID: 30646304.
    Citations:    
  10. Sagers JE, Brown AS, Vasilijic S, Lewis RM, Sahin MI, Landegger LD, Perlis RH, Kohane IS, Welling DB, Patel CJ, Stankovic KM. Publisher Correction: Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma. Sci Rep. 2018 Nov 23; 8(1):17449. PMID: 30470790.
    Citations:    Fields:    
  11. Perlis RH, Fava M, McCoy TH. Can electronic health records revive central nervous system clinical trials? Mol Psychiatry. 2018 Nov 14. PMID: 30429581.
    Citations:    Fields:    
  12. McCoy TH, Pellegrini AM, Perlis RH. Assessment of Time-Series Machine Learning Methods for Forecasting Hospital Discharge Volume. JAMA Netw Open. 2018 Nov 02; 1(7):e184087. PMID: 30646340.
    Citations:    
  13. Gordon DD, Patel I, Pellegrini AM, Perlis RH. Prevalence and Nature of Financial Considerations Documented in Narrative Clinical Records in Intensive Care Units. JAMA Netw Open. 2018 Nov 02; 1(7):e184178. PMID: 30646344.
    Citations:    
  14. Hart KL, Perlis RH, Perlis CS. Conflict of interest and citation impact among dermatology guideline authors. J Am Acad Dermatol. 2019 Mar; 80(3):813-815. PMID: 30367919.
    Citations:    Fields:    
  15. McCoy TH, Perlis RH. Temporal Trends and Characteristics of Reportable Health Data Breaches, 2010-2017. JAMA. 2018 09 25; 320(12):1282-1284. PMID: 30264106.
    Citations:    Fields:    Translation:Humans
  16. Snapper LA, Hart KL, Venkatesh KK, Kaimal AJ, Perlis RH. Cohort study of the relationship between individual psychotherapy and pregnancy outcomes. J Affect Disord. 2018 10 15; 239:253-257. PMID: 30029152.
    Citations:    
  17. Fabbri C, Tansey KE, Perlis RH, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Breen G, Curtis C, Lee SH, Newhouse S, Patel H, O'Donovan M, Lewis G, Jenkins G, Weinshilboum RM, Farmer A, Aitchison KJ, Craig I, McGuffin P, Schruers K, Biernacka JM, Uher R, Lewis CM. Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies. Eur Neuropsychopharmacol. 2018 08; 28(8):945-954. PMID: 30135031.
    Citations:    Fields:    
  18. McCoy TH, Fragomen AT, Hart KL, Pellegrini AM, Raskin KA, Perlis RH. Genomewide Association Study of Fracture Nonunion Using Electronic Health Records. JBMR Plus. 2019 Jan; 3(1):23-28. PMID: 30680360.
    Citations:    
  19. Fabbri C, Lewis CM, Perlis RH, Uher R. No Association Between Antidepressant Efficacy and rs28365143 in Corticotropin-Releasing Hormone Binding Protein in a Large Meta-Analysis. Am J Psychiatry. 2018 Jun 01; 175(6):575-576. PMID: 29869543.
    Citations:    Fields:    
  20. Reinbold CS, Forstner AJ, Hecker J, Fullerton JM, Hoffmann P, Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Marie-Claire C, Cervantes P, Chen GB, Chen HC, Chillotti C, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dayer A, Étain B, Falkai P, Frisén L, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Jamain S, Jiménez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Lackner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, López Jaramillo CA, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Ösby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemüller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm TJ, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt SH, Wright AJ, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus E, Novák T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe JR, Alda M, McMahon FJ, Schulze TG, Rietschel M, Nöthen MM, Cichon S. Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder. Front Psychiatry. 2018; 9:207. PMID: 29904359.
    Citations:    
  21. Brown HE, Hart KL, Snapper LA, Roffman JL, Perlis RH. Impairment in delay discounting in schizophrenia and schizoaffective disorder but not primary mood disorders. NPJ Schizophr. 2018 May 28; 4(1):9. PMID: 29808011.
    Citations:    
  22. Perlis RH, Mehta R, Edwards AM, Tiwari A, Imbens GW. Pharmacogenetic testing among patients with mood and anxiety disorders is associated with decreased utilization and cost: A propensity-score matched study. Depress Anxiety. 2018 10; 35(10):946-952. PMID: 29734486.
    Citations:    Fields:    
  23. Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, Adams MJ, Agerbo E, Air TM, Andlauer TMF, Bacanu SA, Bækvad-Hansen M, Beekman AFT, Bigdeli TB, Binder EB, Blackwood DRH, Bryois J, Buttenschøn HN, Bybjerg-Grauholm J, Cai N, Castelao E, Christensen JH, Clarke TK, Coleman JIR, Colodro-Conde L, Couvy-Duchesne B, Craddock N, Crawford GE, Crowley CA, Dashti HS, Davies G, Deary IJ, Degenhardt F, Derks EM, Direk N, Dolan CV, Dunn EC, Eley TC, Eriksson N, Escott-Price V, Kiadeh FHF, Finucane HK, Forstner AJ, Frank J, Gaspar HA, Gill M, Giusti-Rodríguez P, Goes FS, Gordon SD, Grove J, Hall LS, Hannon E, Hansen CS, Hansen TF, Herms S, Hickie IB, Hoffmann P, Homuth G, Horn C, Hottenga JJ, Hougaard DM, Hu M, Hyde CL, Ising M, Jansen R, Jin F, Jorgenson E, Knowles JA, Kohane IS, Kraft J, Kretzschmar WW, Krogh J, Kutalik Z, Lane JM, Li Y, Li Y, Lind PA, Liu X, Lu L, MacIntyre DJ, MacKinnon DF, Maier RM, Maier W, Marchini J, Mbarek H, McGrath P, McGuffin P, Medland SE, Mehta D, Middeldorp CM, Mihailov E, Milaneschi Y, Milani L, Mill J, Mondimore FM, Montgomery GW, Mostafavi S, Mullins N, Nauck M, Ng B, Nivard MG, Nyholt DR, O'Reilly PF, Oskarsson H, Owen MJ, Painter JN, Pedersen CB, Pedersen MG, Peterson RE, Pettersson E, Peyrot WJ, Pistis G, Posthuma D, Purcell SM, Quiroz JA, Qvist P, Rice JP, Riley BP, Rivera M, Saeed Mirza S, Saxena R, Schoevers R, Schulte EC, Shen L, Shi J, Shyn SI, Sigurdsson E, Sinnamon GBC, Smit JH, Smith DJ, Stefansson H, Steinberg S, Stockmeier CA, Streit F, Strohmaier J, Tansey KE, Teismann H, Teumer A, Thompson W, Thomson PA, Thorgeirsson TE, Tian C, Traylor M, Treutlein J, Trubetskoy V, Uitterlinden AG, Umbricht D, Van der Auwera S, van Hemert AM, Viktorin A, Visscher PM, Wang Y, Webb BT, Weinsheimer SM, Wellmann J, Willemsen G, Witt SH, Wu Y, Xi HS, Yang J, Zhang F, Arolt V, Baune BT, Berger K, Boomsma DI, Cichon S, Dannlowski U, de Geus ECJ, DePaulo JR, Domenici E, Domschke K, Esko T, Grabe HJ, Hamilton SP, Hayward C, Heath AC, Hinds DA, Kendler KS, Kloiber S, Lewis G, Li QS, Lucae S, Madden PFA, Magnusson PK, Martin NG, McIntosh AM, Metspalu A, Mors O, Mortensen PB, Müller-Myhsok B, Nordentoft M, Nöthen MM, O'Donovan MC, Paciga SA, Pedersen NL, Penninx BWJH, Perlis RH, Porteous DJ, Potash JB, Preisig M, Rietschel M, Schaefer C, Schulze TG, Smoller JW, Stefansson K, Tiemeier H, Uher R, Völzke H, Weissman MM, Werge T, Winslow AR, Lewis CM, Levinson DF, Breen G, Børglum AD, Sullivan PF. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet. 2018 May; 50(5):668-681. PMID: 29700475.
    Citations: 22     Fields:    
  24. Perlis RH. Anxiety About Antidepressants. Am J Psychiatry. 2018 Jun 01; 175(6):500-501. PMID: 29690791.
    Citations:    Fields:    
  25. Chen CY, Lee PH, Castro VM, Minnier J, Charney AW, Stahl EA, Ruderfer DM, Murphy SN, Gainer V, Cai T, Jones I, Pato CN, Pato MT, Landén M, Sklar P, Perlis RH, Smoller JW. Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records. Transl Psychiatry. 2018 04 18; 8(1):86. PMID: 29666432.
    Citations: 1     Fields:    Translation:Humans
  26. Freedman R, Brown AS, Cannon TD, Druss BG, Earls FJ, Escobar J, Hurd YL, Lewis DA, López-Jaramillo C, Luby J, Mayberg HS, Moffitt TE, Oquendo M, Perlis RH, Pine DS, Rush AJ, Tamminga CA, Tohen M, Vieta E, Wisner KL, Xin Y. Can a Framework Be Established for the Safe Use of Ketamine? Am J Psychiatry. 2018 Jul 01; 175(7):587-589. PMID: 29656666.
    Citations: 1     Fields:    
  27. Sagers JE, Brown AS, Vasilijic S, Lewis RM, Sahin MI, Landegger LD, Perlis RH, Kohane IS, Welling DB, Patel CJ, Stankovic KM. Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma. Sci Rep. 2018 Apr 03; 8(1):5437. PMID: 29615643.
    Citations:    Fields:    
  28. McCoy TH, Hart K, Pellegrini A, Perlis RH. Genome-wide association identifies a novel locus for delirium risk. Neurobiol Aging. 2018 08; 68:160.e9-160.e14. PMID: 29631748.
    Citations:    Fields:    Translation:Humans
  29. McCoy TH, Castro VM, Hart KL, Pellegrini AM, Yu S, Cai T, Perlis RH. Genome-wide Association Study of Dimensional Psychopathology Using Electronic Health Records. Biol Psychiatry. 2018 Jun 15; 83(12):1005-1011. PMID: 29496196.
    Citations: 1     Fields:    
  30. McCoy TH, Yu S, Hart KL, Castro VM, Brown HE, Rosenquist JN, Doyle AE, Vuijk PJ, Cai T, Perlis RH. High Throughput Phenotyping for Dimensional Psychopathology in Electronic Health Records. Biol Psychiatry. 2018 Jun 15; 83(12):997-1004. PMID: 29496195.
    Citations: 1     Fields:    
  31. Fabbri C, Tansey KE, Perlis RH, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Breen G, Curtis C, Sang-Hyuk L, Newhouse S, Patel H, Guipponi M, Perroud N, Bondolfi G, O'Donovan M, Lewis G, Biernacka JM, Weinshilboum RM, Farmer A, Aitchison KJ, Craig I, McGuffin P, Uher R, Lewis CM. New insights into the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation. Pharmacogenomics J. 2018 05 22; 18(3):413-421. PMID: 29160301.
    Citations: 1     Fields:    Translation:Humans
  32. Rosenberg MA, Lubitz SA, Lin H, Kosova G, Castro VM, Huang P, Ellinor PT, Perlis RH, Newton-Cheh C. Validation of Polygenic Scores for QT Interval in Clinical Populations. Circ Cardiovasc Genet. 2017 Oct; 10(5). PMID: 28986454.
    Citations:    Fields:    Translation:Humans
  33. McCoy TH, Castro VM, Snapper L, Hart K, Januzzi JL, Huffman JC, Perlis RH. Polygenic loading for major depression is associated with specific medical comorbidity. Transl Psychiatry. 2017 09 19; 7(9):e1238. PMID: 28926002.
    Citations: 3     Fields:    Translation:Humans
  34. McCoy TH, Castro VM, Snapper LA, Hart KL, Perlis RH. Efficient genome-wide association in biobanks using topic modeling identifies multiple novel disease loci. Mol Med. 2017 11; 23:285-294. PMID: 28861588.
    Citations:    Fields:    Translation:Humans
  35. McCoy TH, Castro VM, Cagan A, Snapper L, Roberson A, Perlis RH. Cytochrome P450 interactions are common and consequential in Massachusetts hospital discharges. Pharmacogenomics J. 2018 04; 18(2):347-350. PMID: 28696416.
    Citations:    Fields:    
  36. Venkatesh KK, Castro VM, Perlis RH, Kaimal AJ. Impact of antidepressant treatment during pregnancy on obstetric outcomes among women previously treated for depression: an observational cohort study. J Perinatol. 2017 09; 37(9):1003-1009. PMID: 28682318.
    Citations:    Fields:    Translation:Humans
  37. Ravichandran C, Shinn AK, Öngür D, Perlis RH, Cohen B. Frequency of non-right-handedness in bipolar disorder and schizophrenia. Psychiatry Res. 2017 07; 253:267-269. PMID: 28411573.
    Citations:    Fields:    Translation:Humans
  38. Bigdeli TB, Ripke S, Peterson RE, Trzaskowski M, Bacanu SA, Abdellaoui A, Andlauer TF, Beekman AT, Berger K, Blackwood DH, Boomsma DI, Breen G, Buttenschøn HN, Byrne EM, Cichon S, Clarke TK, Couvy-Duchesne B, Craddock N, de Geus EJ, Degenhardt F, Dunn EC, Edwards AC, Fanous AH, Forstner AJ, Frank J, Gill M, Gordon SD, Grabe HJ, Hamilton SP, Hardiman O, Hayward C, Heath AC, Henders AK, Herms S, Hickie IB, Hoffmann P, Homuth G, Hottenga JJ, Ising M, Jansen R, Kloiber S, Knowles JA, Lang M, Li QS, Lucae S, MacIntyre DJ, Madden PA, Martin NG, McGrath PJ, McGuffin P, McIntosh AM, Medland SE, Mehta D, Middeldorp CM, Milaneschi Y, Montgomery GW, Mors O, Müller-Myhsok B, Nauck M, Nyholt DR, Nöthen MM, Owen MJ, Penninx BW, Pergadia ML, Perlis RH, Peyrot WJ, Porteous DJ, Potash JB, Rice JP, Rietschel M, Riley BP, Rivera M, Schoevers R, Schulze TG, Shi J, Shyn SI, Smit JH, Smoller JW, Streit F, Strohmaier J, Teumer A, Treutlein J, Van der Auwera S, van Grootheest G, van Hemert AM, Völzke H, Webb BT, Weissman MM, Wellmann J, Willemsen G, Witt SH, Levinson DF, Lewis CM, Wray NR, Flint J, Sullivan PF, Kendler KS. Genetic effects influencing risk for major depressive disorder in China and Europe. Transl Psychiatry. 2017 03 28; 7(3):e1074. PMID: 28350396.
    Citations: 6     Fields:    Translation:Humans
  39. Venkatesh KK, Kaimal AJ, Castro VM, Perlis RH. Improving discrimination in antepartum depression screening using the Edinburgh Postnatal Depression Scale. J Affect Disord. 2017 05; 214:1-7. PMID: 28260619.
    Citations:    
  40. McCoy TH, Castro VM, Cagan A, Roberson AM, Perlis RH. Validation of a risk stratification tool for fall-related injury in a state-wide cohort. BMJ Open. 2017 02 06; 7(2):e012189. PMID: 28167743.
    Citations: 1     Fields:    Translation:Humans
  41. García-González J, Tansey KE, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Žagar T, Czerski PM, Jerman B, Buttenschøn HN, Schulze TG, Zobel A, Farmer A, Aitchison KJ, Craig I, McGuffin P, Giupponi M, Perroud N, Bondolfi G, Evans D, O'Donovan M, Peters TJ, Wendland JR, Lewis G, Kapur S, Perlis R, Arolt V, Domschke K, Breen G, Curtis C, Sang-Hyuk L, Kan C, Newhouse S, Patel H, Baune BT, Uher R, Lewis CM, Fabbri C. Pharmacogenetics of antidepressant response: A polygenic approach. Prog Neuropsychopharmacol Biol Psychiatry. 2017 04 03; 75:128-134. PMID: 28159590.
    Citations: 3     Fields:    Translation:Humans
  42. McCoy TH, Hart KL, Perlis RH. Characterizing and predicting rates of delirium across general hospital settings. Gen Hosp Psychiatry. 2017 05; 46:1-6. PMID: 28622808.
    Citations: 1     Fields:    Translation:Humans
  43. Charney AW, Ruderfer DM, Stahl EA, Moran JL, Chambert K, Belliveau RA, Forty L, Gordon-Smith K, Di Florio A, Lee PH, Bromet EJ, Buckley PF, Escamilla MA, Fanous AH, Fochtmann LJ, Lehrer DS, Malaspina D, Marder SR, Morley CP, Nicolini H, Perkins DO, Rakofsky JJ, Rapaport MH, Medeiros H, Sobell JL, Green EK, Backlund L, Bergen SE, Juréus A, Schalling M, Lichtenstein P, Roussos P, Knowles JA, Jones I, Jones LA, Hultman CM, Perlis RH, Purcell SM, McCarroll SA, Pato CN, Pato MT, Craddock N, Landén M, Smoller JW, Sklar P. Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder. Transl Psychiatry. 2017 01 10; 7(1):e993. PMID: 28072414.
    Citations: 13     Fields:    Translation:HumansCells
  44. Pavlova B, Perlis RH, Mantere O, Sellgren CM, Isometsä E, Mitchell PB, Alda M, Uher R. Prevalence of current anxiety disorders in people with bipolar disorder during euthymia: a meta-analysis. Psychol Med. 2017 Apr; 47(6):1107-1115. PMID: 27995827.
    Citations: 1     Fields:    Translation:Humans
  45. Sellgren CM, Sheridan SD, Gracias J, Xuan D, Fu T, Perlis RH. Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors. Mol Psychiatry. 2017 02; 22(2):170-177. PMID: 27956744.
    Citations: 6     Fields:    Translation:HumansCells
  46. Direk N, Williams S, Smith JA, Ripke S, Air T, Amare AT, Amin N, Baune BT, Bennett DA, Blackwood DHR, Boomsma D, Breen G, Buttenschøn HN, Byrne EM, Børglum AD, Castelao E, Cichon S, Clarke TK, Cornelis MC, Dannlowski U, De Jager PL, Demirkan A, Domenici E, van Duijn CM, Dunn EC, Eriksson JG, Esko T, Faul JD, Ferrucci L, Fornage M, de Geus E, Gill M, Gordon SD, Grabe HJ, van Grootheest G, Hamilton SP, Hartman CA, Heath AC, Hek K, Hofman A, Homuth G, Horn C, Jan Hottenga J, Kardia SLR, Kloiber S, Koenen K, Kutalik Z, Ladwig KH, Lahti J, Levinson DF, Lewis CM, Lewis G, Li QS, Llewellyn DJ, Lucae S, Lunetta KL, MacIntyre DJ, Madden P, Martin NG, McIntosh AM, Metspalu A, Milaneschi Y, Montgomery GW, Mors O, Mosley TH, Murabito JM, Müller-Myhsok B, Nöthen MM, Nyholt DR, O'Donovan MC, Penninx BW, Pergadia ML, Perlis R, Potash JB, Preisig M, Purcell SM, Quiroz JA, Räikkönen K, Rice JP, Rietschel M, Rivera M, Schulze TG, Shi J, Shyn S, Sinnamon GC, Smit JH, Smoller JW, Snieder H, Tanaka T, Tansey KE, Teumer A, Uher R, Umbricht D, Van der Auwera S, Ware EB, Weir DR, Weissman MM, Willemsen G, Yang J, Zhao W, Tiemeier H, Sullivan PF. An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype. Biol Psychiatry. 2017 09 01; 82(5):322-329. PMID: 28049566.
    Citations: 12     Fields:    Translation:Humans
  47. McCoy TH, Chaukos DC, Snapper LA, Hart KL, Stern TA, Perlis RH. Enhancing Delirium Case Definitions in Electronic Health Records Using Clinical Free Text. Psychosomatics. 2017 Mar - Apr; 58(2):113-120. PMID: 28087072.
    Citations: 1     Fields:    Translation:Humans
  48. Rumshisky A, Ghassemi M, Naumann T, Szolovits P, Castro VM, McCoy TH, Perlis RH. Predicting early psychiatric readmission with natural language processing of narrative discharge summaries. Transl Psychiatry. 2016 10 18; 6(10):e921. PMID: 27754482.
    Citations: 9     Fields:    Translation:Humans
  49. McCoy TH, Castro VM, Roberson AM, Snapper LA, Perlis RH. Improving Prediction of Suicide and Accidental Death After Discharge From General Hospitals With Natural Language Processing. JAMA Psychiatry. 2016 Oct 01; 73(10):1064-1071. PMID: 27626235.
    Citations: 6     Fields:    Translation:Humans
  50. Perlis RH. Abandoning personalization to get to precision in the pharmacotherapy of depression. World Psychiatry. 2016 Oct; 15(3):228-235. PMID: 27717262.
    Citations: 6     
  51. Barak-Corren Y, Castro VM, Javitt S, Hoffnagle AG, Dai Y, Perlis RH, Nock MK, Smoller JW, Reis BY. Predicting Suicidal Behavior From Longitudinal Electronic Health Records. Am J Psychiatry. 2017 Feb 01; 174(2):154-162. PMID: 27609239.
    Citations: 6     Fields:    Translation:Humans
  52. Harper DG, Jensen JE, Ravichandran C, Perlis RH, Fava M, Renshaw PF, Iosifescu DV. Tissue Type-Specific Bioenergetic Abnormalities in Adults with Major Depression. Neuropsychopharmacology. 2017 Mar; 42(4):876-885. PMID: 27585738.
    Citations: 2     Fields:    Translation:Humans
  53. Bernhard RM, Chaponis J, Siburian R, Gallagher P, Ransohoff K, Wikler D, Perlis RH, Greene JD. Variation in the oxytocin receptor gene (OXTR) is associated with differences in moral judgment. Soc Cogn Affect Neurosci. 2016 12; 11(12):1872-1881. PMID: 27497314.
    Citations: 4     Fields:    Translation:Humans
  54. Hyde CL, Nagle MW, Tian C, Chen X, Paciga SA, Wendland JR, Tung JY, Hinds DA, Perlis RH, Winslow AR. Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. Nat Genet. 2016 09; 48(9):1031-6. PMID: 27479909.
    Citations: 72     Fields:    Translation:Humans
  55. Perlis RH. Autism and antidepressant use in pregnancy. J Pediatr. 2016 07; 174:278. PMID: 27346512.
    Citations:    Fields:    Translation:Humans
  56. Liang SH, Chen JM, Normandin MD, Chang JS, Chang GC, Taylor CK, Trapa P, Plummer MS, Para KS, Conn EL, Lopresti-Morrow L, Lanyon LF, Cook JM, Richter KE, Nolan CE, Schachter JB, Janat F, Che Y, Shanmugasundaram V, Lefker BA, Enerson BE, Livni E, Wang L, Guehl NJ, Patnaik D, Wagner FF, Perlis R, Holson EB, Haggarty SJ, El Fakhri G, Kurumbail RG, Vasdev N. Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging. Angew Chem Int Ed Engl. 2016 08 08; 55(33):9601-5. PMID: 27355874.
    Citations: 5     Fields:    Translation:HumansCells
  57. McCoy TH, Snapper L, Stern TA, Perlis RH. Underreporting of Delirium in Statewide Claims Data: Implications for Clinical Care and Predictive Modeling. Psychosomatics. 2016 Sep-Oct; 57(5):480-8. PMID: 27480944.
    Citations: 4     Fields:    Translation:Humans
  58. Corral-Frías NS, Pizzagalli DA, Carré JM, Michalski LJ, Nikolova YS, Perlis RH, Fagerness J, Lee MR, Conley ED, Lancaster TM, Haddad S, Wolf A, Smoller JW, Hariri AR, Bogdan R. COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis. Genes Brain Behav. 2016 06; 15(5):503-13. PMID: 27138112; PMCID: PMC4891272.
    Citations: 1     Fields:    Translation:Humans
  59. Perlis RH, Perlis CS. Physician Payments from Industry Are Associated with Greater Medicare Part D Prescribing Costs. PLoS One. 2016; 11(5):e0155474. PMID: 27183221.
    Citations: 12     Fields:    Translation:Humans
  60. McCoy TH, Castro VM, Cagan A, Roberson AM, Perlis RH. Prevalence and implications of cytochrome P450 substrates in Massachusetts hospital discharges. Pharmacogenomics J. 2017 07; 17(4):382-385. PMID: 27168099.
    Citations:    Fields:    Translation:HumansCells
  61. Venkatesh KK, Riley L, Castro VM, Perlis RH, Kaimal AJ. Association of Antenatal Depression Symptoms and Antidepressant Treatment With Preterm Birth. Obstet Gynecol. 2016 05; 127(5):926-33. PMID: 27054941.
    Citations: 3     Fields:    Translation:Humans
  62. Roberson AM, Castro VM, Cagan A, Perlis RH. Antidepressant nonadherence in routine clinical settings determined from discarded blood samples. J Clin Psychiatry. 2016 Mar; 77(3):359-62. PMID: 26613178.
    Citations: 1     Fields:    Translation:Humans
  63. Vöhringer PA, Perlis RH. Discriminating Between Bipolar Disorder and Major Depressive Disorder. Psychiatr Clin North Am. 2016 Mar; 39(1):1-10. PMID: 26876315.
    Citations: 3     Fields:    Translation:Humans
  64. Balekian DS, Linnemann RW, Castro VM, Perlis R, Thadhani R, Camargo CA. Pre-birth cohort study of atopic dermatitis and severe bronchiolitis during infancy. Pediatr Allergy Immunol. 2016 06; 27(4):413-8. PMID: 26766307.
    Citations: 1     Fields:    Translation:Humans
  65. Sylvia LG, Gold AK, Stange JP, Peckham AD, Deckersbach T, Calabrese JR, Weiss RD, Perlis RH, Nierenberg AA, Ostacher MJ. A randomized, placebo-controlled proof-of-concept trial of adjunctive topiramate for alcohol use disorders in bipolar disorder. Am J Addict. 2016 Mar; 25(2):94-8. PMID: 26894822; PMCID: PMC4791182.
    Citations: 5     Fields:    Translation:Humans
  66. Haggarty SJ, Silva MC, Cross A, Brandon NJ, Perlis RH. Advancing drug discovery for neuropsychiatric disorders using patient-specific stem cell models. Mol Cell Neurosci. 2016 06; 73:104-15. PMID: 26826498.
    Citations: 10     Fields:    Translation:HumansCells
  67. Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Banzato CEM, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Brichant-Petitjean C, Bui ET, Cervantes P, Chen GB, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dantas CR, Dayer A, Étain B, Falkai P, Forstner AJ, Frisén L, Fullerton JM, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Lackner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Jaramillo CAL, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Ösby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemüller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm T, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt S, Wright A, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus EZ, Novák T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe JR, Alda M, Rietschel M, McMahon FJ, Schulze TG. Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. Lancet. 2016 Mar 12; 387(10023):1085-1093. PMID: 26806518.
    Citations: 28     Fields:    Translation:HumansCTClinical Trials
  68. Castro VM, Kong SW, Clements CC, Brady R, Kaimal AJ, Doyle AE, Robinson EB, Churchill SE, Kohane IS, Perlis RH. Absence of evidence for increase in risk for autism or attention-deficit hyperactivity disorder following antidepressant exposure during pregnancy: a replication study. Transl Psychiatry. 2016 Jan 05; 6:e708. PMID: 26731445.
    Citations: 10     Fields:    Translation:Humans
  69. Song J, Bergen SE, Di Florio A, Karlsson R, Charney A, Ruderfer DM, Stahl EA, Chambert KD, Moran JL, Gordon-Smith K, Forty L, Green EK, Jones I, Jones L, Scolnick EM, Sklar P, Smoller JW, Lichtenstein P, Hultman C, Craddock N, Landén M, Smoller JW, Perlis RH, Lee PH, Castro VM, Hoffnagle AG, Sklar P, Stahl EA, Purcell SM, Ruderfer DM, Charney AW, Roussos P, Michele Pato CP, Medeiros H, Sobel J, Craddock N, Jones I, Forty L, Florio AD, Green E, Jones L, Gordon-Smith K, Landen M, Hultman C, Jureus A, Bergen S, McCarroll S, Moran J, Smoller JW, Chambert K, Belliveau RA. Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder. Mol Psychiatry. 2016 09; 21(9):1290-7. PMID: 26503763.
    Citations: 5     Fields:    Translation:Humans
  70. Perlis RH. Getting Past Proof of Concept For New Treatments. Am J Psychiatry. 2015 Oct; 172(10):937-8. PMID: 26423476.
    Citations:    Fields:    Translation:Humans
  71. McGrath LM, Braaten EB, Doty ND, Willoughby BL, Wilson HK, O'Donnell EH, Colvin MK, Ditmars HL, Blais JE, Hill EN, Metzger A, Perlis RH, Willcutt EG, Smoller JW, Waldman ID, Faraone SV, Seidman LJ, Doyle AE. Extending the 'cross-disorder' relevance of executive functions to dimensional neuropsychiatric traits in youth. J Child Psychol Psychiatry. 2016 Apr; 57(4):462-71. PMID: 26411927.
    Citations: 7     Fields:    Translation:Humans
  72. McCoy TH, Castro VM, Cagan A, Roberson AM, Kohane IS, Perlis RH. Sentiment Measured in Hospital Discharge Notes Is Associated with Readmission and Mortality Risk: An Electronic Health Record Study. PLoS One. 2015; 10(8):e0136341. PMID: 26302085; PMCID: PMC4547711.
    Citations: 5     Fields:    Translation:Humans
  73. Castro VM, Roberson AM, McCoy TH, Wiste A, Cagan A, Smoller JW, Rosenbaum JF, Ostacher M, Perlis RH. Stratifying Risk for Renal Insufficiency Among Lithium-Treated Patients: An Electronic Health Record Study. Neuropsychopharmacology. 2016 Mar; 41(4):1138-43. PMID: 26294109; PMCID: PMC4748438.
    Citations: 4     Fields:    Translation:Humans
  74. Uchida M, Spencer AE, Biederman J, Castro VM, Kenworthy T, Chan J, Rosales AM, Newton-Cheh C, Perlis RH. A Systematic Evaluation of the QTc Interval and Antidepressants in Youth: An Electronic Health Record Study. J Dev Behav Pediatr. 2015 Jul-Aug; 36(6):434-9. PMID: 26154713.
    Citations: 1     Fields:    Translation:Humans
  75. Pavlova B, Perlis RH, Alda M, Uher R. Lifetime prevalence of anxiety disorders in people with bipolar disorder: a systematic review and meta-analysis. Lancet Psychiatry. 2015 Aug; 2(8):710-717. PMID: 26249302.
    Citations: 11     Fields:    Translation:Humans
  76. Ostacher MJ, Perlis RH, Geddes J. Monotherapy Antidepressant Treatment is Not Associated With Mania in Bipolar I Disorder. Am J Psychiatry. 2015 Jun; 172(6):586. PMID: 26029807.
    Citations:    Fields:    Translation:Humans
  77. Rotstein BH, Liang SH, Belov VV, Livni E, Levine DB, Bonab AA, Papisov MI, Perlis RH, Vasdev N. Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, a Calcium Channel Antagonist. Molecules. 2015 May 26; 20(6):9550-9. PMID: 26016546; PMCID: PMC4870226.
    Citations:    Fields:    Translation:Animals
  78. Bavamian S, Mellios N, Lalonde J, Fass DM, Wang J, Sheridan SD, Madison JM, Zhou F, Rueckert EH, Barker D, Perlis RH, Sur M, Haggarty SJ. Noncoding RNAs connect genetic risk factors to the neurodevelopmental basis of bipolar disorder. Mol Psychiatry. 2015 May; 20(5):548. PMID: 25921437.
    Citations:    Fields:    Translation:Humans
  79. Brennan FX, Gardner KR, Lombard J, Perlis RH, Fava M, Harris HW, Scott R. A Naturalistic Study of the Effectiveness of Pharmacogenetic Testing to Guide Treatment in Psychiatric Patients With Mood and Anxiety Disorders. Prim Care Companion CNS Disord. 2015; 17(2). PMID: 26445691; PMCID: PMC4560190.
    Citations: 2     Fields:    
  80. Uher R, Ripke S, Müller-Myhsok B, Lewis CM, Perlis RH. Association of a brain methylation site with clinical outcomes in depression does not replicate across populations. Am J Psychiatry. 2015 Apr; 172(4):395-7. PMID: 25827039.
    Citations:    Fields:    Translation:Humans
  81. McCoy TH, Castro VM, Rosenfield HR, Cagan A, Kohane IS, Perlis RH. A clinical perspective on the relevance of research domain criteria in electronic health records. Am J Psychiatry. 2015 Apr; 172(4):316-20. PMID: 25827030.
    Citations: 6     Fields:    Translation:Humans
  82. Madison JM, Zhou F, Nigam A, Hussain A, Barker DD, Nehme R, van der Ven K, Hsu J, Wolf P, Fleishman M, O'Dushlaine C, Rose S, Chambert K, Lau FH, Ahfeldt T, Rueckert EH, Sheridan SD, Fass DM, Nemesh J, Mullen TE, Daheron L, McCarroll S, Sklar P, Perlis RH, Haggarty SJ. Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities. Mol Psychiatry. 2015 Jun; 20(6):703-17. PMID: 25733313; PMCID: PMC4440839.
    Citations: 35     Fields:    Translation:HumansCells
  83. Ramos EM, Gillis T, Mysore JS, Lee JM, Alonso I, Gusella JF, Smoller JW, Sklar P, MacDonald ME, Perlis RH. Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder. Bipolar Disord. 2015 Jun; 17(4):403-8. PMID: 25726852.
    Citations: 2     Fields:    Translation:HumansCells
  84. McCoy TH, Perlis RH. A tool to utilize adverse effect profiles to identify brain-active medications for repurposing. Int J Neuropsychopharmacol. 2015 Feb; 18(3). PMID: 25673184; PMCID: PMC4360243.
    Citations: 1     Fields:    Translation:Humans
  85. Bavamian S, Mellios N, Lalonde J, Fass DM, Wang J, Sheridan SD, Madison JM, Zhou F, Rueckert EH, Barker D, Perlis RH, Sur M, Haggarty SJ. Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder. Mol Psychiatry. 2015 May; 20(5):573-84. PMID: 25623948; PMCID: PMC4414679.
    Citations: 26     Fields:    Translation:HumansCells
  86. Yoshimizu T, Pan JQ, Mungenast AE, Madison JM, Su S, Ketterman J, Ongur D, McPhie D, Cohen B, Perlis R, Tsai LH. Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Mol Psychiatry. 2015 Feb; 20(2):284. PMID: 25623946.
    Citations: 7     Fields:    
  87. Castro VM, Minnier J, Murphy SN, Kohane I, Churchill SE, Gainer V, Cai T, Hoffnagle AG, Dai Y, Block S, Weill SR, Nadal-Vicens M, Pollastri AR, Rosenquist JN, Goryachev S, Ongur D, Sklar P, Perlis RH, Smoller JW. Validation of electronic health record phenotyping of bipolar disorder cases and controls. Am J Psychiatry. 2015 Apr; 172(4):363-72. PMID: 25827034.
    Citations: 17     Fields:    Translation:Humans
  88. Perlis RH. From bench to bedlam. Am J Psychiatry. 2014 Dec 01; 171(12):1233-5. PMID: 25756761.
    Citations:    Fields:    Translation:HumansCells
  89. Yoshimizu T, Pan JQ, Mungenast AE, Madison JM, Su S, Ketterman J, Ongur D, McPhie D, Cohen B, Perlis R, Tsai LH. Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Mol Psychiatry. 2015 Feb; 20(2):162-9. PMID: 25403839; PMCID: PMC4394050.
    Citations: 32     Fields:    Translation:HumansCells
  90. Perlis RH. Use of large data sets and the future of personalized treatment. Depress Anxiety. 2014 Nov; 31(11):916-9. PMID: 25407581.
    Citations: 1     Fields:    Translation:Humans
  91. Castro VM, McCoy TH, Cagan A, Rosenfield HR, Murphy SN, Churchill SE, Kohane IS, Perlis RH. Stratification of risk for hospital admissions for injury related to fall: cohort study. BMJ. 2014 Oct 24; 349:g5863. PMID: 25954985; PMCID: PMC4208628.
    Citations: 9     Fields:    Translation:Humans
  92. Robinson EB, Samocha KE, Kosmicki JA, McGrath L, Neale BM, Perlis RH, Daly MJ. Autism spectrum disorder severity reflects the average contribution of de novo and familial influences. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15161-5. PMID: 25288738.
    Citations: 27     Fields:    Translation:Humans
  93. Clements CC, Castro VM, Blumenthal SR, Rosenfield HR, Murphy SN, Fava M, Erb JL, Churchill SE, Kaimal AJ, Doyle AE, Robinson EB, Smoller JW, Kohane IS, Perlis RH. Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system. Mol Psychiatry. 2015 Jun; 20(6):727-34. PMID: 25155880; PMCID: PMC4427538.
    Citations: 36     Fields:    Translation:Humans
  94. Wang JL, Shamah SM, Sun AX, Waldman ID, Haggarty SJ, Perlis RH. Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness. Transl Psychiatry. 2014 Aug 26; 4:e428. PMID: 25158003; PMCID: PMC4150245.
    Citations: 9     Fields: