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Laurence G. Rahme, Ph.D.

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Overview

Mentoring
Available: 10/01/18, Expires: 09/30/22

Bacterial quorum sensing (QS) signaling molecules are important mediators of immunomodulation. However, how microbes utilize immunomodulatory signals to maintain long-term presence and thwart clearance and how the host avoids harmful inflammatory response as a result of pathogen's presence remain unclear. The project focuses on a previously unidentified link between a microbial derived QS molecule and host immunomodulation mediated by epigenetic and metabolic reprogramming. Elucidation of this reprograming may aid in the understanding of host resilience and immunology memory at large, including host resilience to commensals and and offer opportunities for therapeutic treatments that may train the host to become resilient to pathogen damage.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI134857 (RAHME, LAURENCE G) Jan 1, 2018 - Dec 31, 2022
    NIH/NIAID
    Molecular and Metabolic inter-kingdom actions of a bacterial quorum sensing signal in promotion of host tolerance/resilience.
    Role: Principal Investigator
  2. R33AI105902 (RAHME, LAURENCE G) Apr 1, 2015 - Mar 31, 2018
    NIH/NIAID
    Interruption of Signaling-Mediated Bacterial Persistent Infections
    Role: Principal Investigator
  3. R21AI105902 (RAHME, LAURENCE G) Mar 1, 2013 - Feb 28, 2015
    NIH/NIAID
    Interruption of Signaling-Mediated Bacterial Persistent Infections
    Role: Principal Investigator
  4. R56AI063433 (RAHME, LAURENCE G) Aug 21, 2012 - Jul 31, 2013
    NIH/NIAID
    Function of MVFR in Pseudomonas Aeruginosa Virulence
    Role: Principal Investigator
  5. R01AI063433 (RAHME, LAURENCE G) Apr 1, 2006 - Mar 31, 2011
    NIH/NIAID
    Function of MVFR in Pseudomonas aeruginosa virulence
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kühn F, Adiliaghdam F, Cavallaro PM, Hamarneh SR, Tsurumi A, Hoda RS, Munoz AR, Dhole Y, Ramirez JM, Liu E, Vasan R, Liu Y, Samarbafzadeh E, Nunez RA, Farber MZ, Chopra V, Malo MS, Rahme LG, Hodin RA. Intestinal alkaline phosphatase targets the gut barrier to prevent aging. JCI Insight. 2020 Mar 26; 5(6). PMID: 32213701.
    Citations:    
  2. Bandyopadhaya A, Tzika AA, Rahme LG. Erratum for Bandyopadhaya et al., "Pseudomonas aeruginosa Quorum Sensing Molecule Alters Skeletal Muscle Protein Homeostasis by Perturbing the Antioxidant Defense System". mBio. 2020 Feb 04; 11(1). PMID: 32019795.
    Citations:    
  3. Ogura A, Tsurumi A, Que YA, Almpani M, Zheng H, Tompkins RG, Ryan CM, Rahme LG. Associations between clinical characteristics and the development of multiple organ failure after severe burns in adult patients. Burns. 2019 12; 45(8):1775-1782. PMID: 31690472.
    Citations:    
  4. Kirienko NV, Rahme L, Cho YH. Editorial: Beyond Antimicrobials: Non-traditional Approaches to Combating Multidrug-Resistant Bacteria. Front Cell Infect Microbiol. 2019; 9:343. PMID: 31681623.
    Citations:    
  5. Bandyopadhaya A, Tzika AA, Rahme LG. Pseudomonas aeruginosa Quorum Sensing Molecule Alters Skeletal Muscle Protein Homeostasis by Perturbing the Antioxidant Defense System. mBio. 2019 10 01; 10(5). PMID: 31575771.
    Citations:    
  6. Ji C, Sharma I, Pratihar D, Hudson LL, Maura D, Guney T, Rahme LG, Pesci EC, Coleman JP, Tan DS. Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa. ACS Chem Biol. 2019 Jun 21; 14(6):1380. PMID: 31083966.
    Citations:    
  7. Adiliaghdam F, Almpani M, Gharedaghi MH, Najibi M, Hodin RA, Rahme LG. Targeting bacterial quorum sensing shows promise in improving intestinal barrier function following burn-site infection. Mol Med Rep. 2019 May; 19(5):4057-4066. PMID: 30896813.
    Citations:    
  8. Righi V, Starkey M, Dai G, Rahme LG, Tzika AA. Magnetization transfer contrast MRI in GFP-tagged live bacteria. Mol Med Rep. 2019 Jan; 19(1):617-621. PMID: 30483743.
    Citations:    Fields:    
  9. Righi V, Constantinou C, Kesarwani M, Rahme LG, Tzika AA. Effects of a small, volatile bacterial molecule on Pseudomonas aeruginosa bacteria using whole cell high-resolution magic angle spinning nuclear magnetic resonance spectroscopy and genomics. Int J Mol Med. 2018 Oct; 42(4):2129-2136. PMID: 30015850.
    Citations:    Fields:    Translation:Cells
  10. Kitao T, Lepine F, Babloudi S, Walte F, Steinbacher S, Maskos K, Blaesse M, Negri M, Pucci M, Zahler B, Felici A, Rahme LG. Molecular Insights into Function and Competitive Inhibition of Pseudomonas aeruginosa Multiple Virulence Factor Regulator. mBio. 2018 01 16; 9(1). PMID: 29339431.
    Citations: 2     Fields:    Translation:Cells
  11. Maura D, Bandyopadhaya A, Rahme LG. Animal Models for Pseudomonas aeruginosa Quorum Sensing Studies. Methods Mol Biol. 2018; 1673:227-241. PMID: 29130177.
    Citations:    Fields:    Translation:AnimalsCells
  12. Maura D, Rahme LG. Pharmacological Inhibition of the Pseudomonas aeruginosa MvfR Quorum-Sensing System Interferes with Biofilm Formation and Potentiates Antibiotic-Mediated Biofilm Disruption. Antimicrob Agents Chemother. 2017 12; 61(12). PMID: 28923875.
    Citations: 2     Fields:    Translation:Cells
  13. Bandyopadhaya A, Tsurumi A, Rahme LG. NF-?Bp50 and HDAC1 Interaction Is Implicated in the Host Tolerance to Infection Mediated by the Bacterial Quorum Sensing Signal 2-Aminoacetophenone. Front Microbiol. 2017; 8:1211. PMID: 28713342.
    Citations:    
  14. Allegretta G, Maurer CK, Eberhard J, Maura D, Hartmann RW, Rahme L, Empting M. In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment. Front Microbiol. 2017; 8:924. PMID: 28596760.
    Citations: 1     
  15. Maura D, Drees SL, Bandyopadhaya A, Kitao T, Negri M, Starkey M, Lesic B, Milot S, Déziel E, Zahler R, Pucci M, Felici A, Fetzner S, Lépine F, Rahme LG. Polypharmacology Approaches against the Pseudomonas aeruginosa MvfR Regulon and Their Application in Blocking Virulence and Antibiotic Tolerance. ACS Chem Biol. 2017 05 19; 12(5):1435-1443. PMID: 28379691.
    Citations: 2     Fields:    Translation:Cells
  16. Limoli DH, Whitfield GB, Kitao T, Ivey ML, Davis MR, Grahl N, Hogan DA, Rahme LG, Howell PL, O'Toole GA, Goldberg JB. Pseudomonas aeruginosa Alginate Overproduction Promotes Coexistence with Staphylococcus aureus in a Model of Cystic Fibrosis Respiratory Infection. mBio. 2017 03 21; 8(2). PMID: 28325763.
    Citations: 4     Fields:    Translation:HumansCells
  17. Turnpenny P, Padfield A, Barton P, Teague J, Rahme LG, Pucci MJ, Zahler R, Rubio A. Bioanalysis of Pseudomonas aeruginosa alkyl quinolone signalling molecules in infected mouse tissue using LC-MS/MS; and its application to a pharmacodynamic evaluation of MvfR inhibition. J Pharm Biomed Anal. 2017 May 30; 139:44-53. PMID: 28273650.
    Citations:    Fields:    Translation:HumansAnimalsCells
  18. Tsurumi A, Que YA, Ryan CM, Tompkins RG, Rahme LG. TNF-a/IL-10 Ratio Correlates with Burn Severity and May Serve as a Risk Predictor of Increased Susceptibility to Infections. Front Public Health. 2016; 4:216. PMID: 27761434.
    Citations: 3     
  19. Bandyopadhaya A, Tsurumi A, Maura D, Jeffrey KL, Rahme LG. A quorum-sensing signal promotes host tolerance training through HDAC1-mediated epigenetic reprogramming. Nat Microbiol. 2016 Oct 03; 1:16174. PMID: 27694949.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  20. Maura D, Hazan R, Kitao T, Ballok AE, Rahme LG. Evidence for Direct Control of Virulence and Defense Gene Circuits by the Pseudomonas aeruginosa Quorum Sensing Regulator, MvfR. Sci Rep. 2016 Sep 28; 6:34083. PMID: 27678057.
    Citations: 7     Fields:    
  21. Ji C, Sharma I, Pratihar D, Hudson LL, Maura D, Guney T, Rahme LG, Pesci EC, Coleman JP, Tan DS. Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa. ACS Chem Biol. 2016 11 18; 11(11):3061-3067. PMID: 27658001.
    Citations: 3     Fields:    Translation:Cells
  22. Maura D, Ballok AE, Rahme LG. Considerations and caveats in anti-virulence drug development. Curr Opin Microbiol. 2016 10; 33:41-46. PMID: 27318551.
    Citations: 13     Fields:    Translation:HumansCells
  23. Bandyopadhaya A, Constantinou C, Psychogios N, Ueki R, Yasuhara S, Martyn JA, Wilhelmy J, Mindrinos M, Rahme LG, Tzika AA. Bacterial-excreted small volatile molecule 2-aminoacetophenone induces oxidative stress and apoptosis in murine skeletal muscle. Int J Mol Med. 2016 Apr; 37(4):867-78. PMID: 26935176.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  24. Hazan R, Que YA, Maura D, Strobel B, Majcherczyk PA, Hopper LR, Wilbur DJ, Hreha TN, Barquera B, Rahme LG. Auto Poisoning of the Respiratory Chain by a Quorum-Sensing-Regulated Molecule Favors Biofilm Formation and Antibiotic Tolerance. Curr Biol. 2016 Jan 25; 26(2):195-206. PMID: 26776731.
    Citations: 12     Fields:    Translation:Cells
  25. Constantinou C, Apidianakis Y, Psychogios N, Righi V, Mindrinos MN, Khan N, Swartz HM, Szeto HH, Tompkins RG, Rahme LG, Tzika AA. In vivo high-resolution magic angle spinning magnetic and electron paramagnetic resonance spectroscopic analysis of mitochondria-targeted peptide in Drosophila melanogaster with trauma-induced thoracic injury. Int J Mol Med. 2016 Feb; 37(2):299-308. PMID: 26648055.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  26. Tsurumi A, Que YA, Yan S, Tompkins RG, Rahme LG, Ryan CM. Do standard burn mortality formulae work on a population of severely burned children and adults? Burns. 2015 Aug; 41(5):935-45. PMID: 25922299.
    Citations: 2     Fields:    Translation:Humans
  27. Yan S, Tsurumi A, Que YA, Ryan CM, Bandyopadhaya A, Morgan AA, Flaherty PJ, Tompkins RG, Rahme LG. Prediction of multiple infections after severe burn trauma: a prospective cohort study. Ann Surg. 2015 Apr; 261(4):781-92. PMID: 24950278.
    Citations: 10     Fields:    Translation:HumansCells
  28. Starkey M, Lepine F, Maura D, Bandyopadhaya A, Lesic B, He J, Kitao T, Righi V, Milot S, Tzika A, Rahme L. Identification of anti-virulence compounds that disrupt quorum-sensing regulated acute and persistent pathogenicity. PLoS Pathog. 2014 Aug; 10(8):e1004321. PMID: 25144274.
    Citations: 36     Fields:    Translation:AnimalsCells
  29. Righi V, Apidianakis Y, Psychogios N, Rahme LG, Tompkins RG, Tzika AA. In vivo high-resolution magic angle spinning proton NMR spectroscopy of Drosophila melanogaster flies as a model system to investigate mitochondrial dysfunction in Drosophila GST2 mutants. Int J Mol Med. 2014 Jul; 34(1):327-33. PMID: 24789699.
    Citations: 4     Fields:    Translation:AnimalsCells
  30. Hazan R, Maura D, Que YA, Rahme LG. Assessing Pseudomonas aeruginosa Persister/antibiotic tolerant cells. Methods Mol Biol. 2014; 1149:699-707. PMID: 24818944.
    Citations: 3     Fields:    Translation:Cells
  31. Baldini RL, Starkey M, Rahme LG. Assessing Pseudomonas virulence with the nonmammalian host model: Arabidopsis thaliana. Methods Mol Biol. 2014; 1149:689-97. PMID: 24818943.
    Citations: 2     Fields:    Translation:AnimalsCells
  32. Que YA, Hazan R, Strobel B, Maura D, He J, Kesarwani M, Panopoulos P, Tsurumi A, Giddey M, Wilhelmy J, Mindrinos MN, Rahme LG. A quorum sensing small volatile molecule promotes antibiotic tolerance in bacteria. PLoS One. 2013; 8(12):e80140. PMID: 24367477.
    Citations: 18     Fields:    Translation:Cells
  33. Dulcey CE, Dekimpe V, Fauvelle DA, Milot S, Groleau MC, Doucet N, Rahme LG, Lépine F, Déziel E. The end of an old hypothesis: the pseudomonas signaling molecules 4-hydroxy-2-alkylquinolines derive from fatty acids, not 3-ketofatty acids. Chem Biol. 2013 Dec 19; 20(12):1481-91. PMID: 24239007.
    Citations: 28     Fields:    Translation:Cells
  34. Tzika AA, Constantinou C, Bandyopadhaya A, Psychogios N, Lee S, Mindrinos M, Martyn JA, Tompkins RG, Rahme LG. A small volatile bacterial molecule triggers mitochondrial dysfunction in murine skeletal muscle. PLoS One. 2013; 8(9):e74528. PMID: 24098655.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  35. Righi V, Constantinou C, Kesarwani M, Rahme LG, Tzika AA. Live-cell high resolution magic angle spinning magnetic resonance spectroscopy for in vivo analysis of Pseudomonas aeruginosa metabolomics. Biomed Rep. 2013 Sep; 1(5):707-712. PMID: 24649014.
    Citations: 5     
  36. Tzika AA, Fontes-Oliveira CC, Shestov AA, Constantinou C, Psychogios N, Righi V, Mintzopoulos D, Busquets S, Lopez-Soriano FJ, Milot S, Lepine F, Mindrinos MN, Rahme LG, Argiles JM. Skeletal muscle mitochondrial uncoupling in a murine cancer cachexia model. Int J Oncol. 2013 Sep; 43(3):886-94. PMID: 23817738.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  37. Righi V, Constantinou C, Mintzopoulos D, Khan N, Mupparaju SP, Rahme LG, Swartz HM, Szeto HH, Tompkins RG, Tzika AA. Mitochondria-targeted antioxidant promotes recovery of skeletal muscle mitochondrial function after burn trauma assessed by in vivo 31P nuclear magnetic resonance and electron paramagnetic resonance spectroscopy. FASEB J. 2013 Jun; 27(6):2521-30. PMID: 23482635.
    Citations: 6     Fields:    Translation:AnimalsCells
  38. Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, Richards DR, McDonald-Smith GP, Gao H, Hennessy L, Finnerty CC, López CM, Honari S, Moore EE, Minei JP, Cuschieri J, Bankey PE, Johnson JL, Sperry J, Nathens AB, Billiar TR, West MA, Jeschke MG, Klein MB, Gamelli RL, Gibran NS, Brownstein BH, Miller-Graziano C, Calvano SE, Mason PH, Cobb JP, Rahme LG, Lowry SF, Maier RV, Moldawer LL, Herndon DN, Davis RW, Xiao W, Tompkins RG. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3507-12. PMID: 23401516.
    Citations: 798     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  39. Bandyopadhaya A, Kesarwani M, Que YA, He J, Padfield K, Tompkins R, Rahme LG. The quorum sensing volatile molecule 2-amino acetophenon modulates host immune responses in a manner that promotes life with unwanted guests. PLoS Pathog. 2012; 8(11):e1003024. PMID: 23166496.
    Citations: 16     Fields:    Translation:AnimalsCells
  40. Hazan R, Que YA, Maura D, Rahme LG. A method for high throughput determination of viable bacteria cell counts in 96-well plates. BMC Microbiol. 2012 Nov 13; 12:259. PMID: 23148795.
    Citations: 12     Fields:    Translation:Cells
  41. Papagiannaros A, Righi V, Day GG, Rahme LG, Liu PK, Fischman AJ, Tompkins RG, Tzika AA. Imaging C-Fos Gene Expression in Burns Using Lipid Coated Spion Nanoparticles. Adv J Mol Imaging. 2012 Oct; 2(4):31-37. PMID: 24995147.
    Citations:    
  42. Bangi E, Pitsouli C, Rahme LG, Cagan R, Apidianakis Y. Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells. EMBO Rep. 2012 Jun 01; 13(6):569-76. PMID: 22498775.
    Citations: 18     Fields:    Translation:AnimalsCells
  43. Wang R, Starkey M, Hazan R, Rahme LG. Honey's Ability to Counter Bacterial Infections Arises from Both Bactericidal Compounds and QS Inhibition. Front Microbiol. 2012; 3:144. PMID: 22514552.
    Citations: 10     
  44. Ryou M, Hazan R, Rahme L, Thompson CC. An ex vivo bacteriologic study comparing antiseptic techniques for natural orifice translumenal endoscopic surgery (NOTES) via the gastrointestinal tract. Dig Dis Sci. 2012 Aug; 57(8):2130-6. PMID: 22447433.
    Citations: 2     Fields:    Translation:Animals
  45. Apidianakis Y, Que YA, Xu W, Tegos GP, Zimniak P, Hamblin MR, Tompkins RG, Xiao W, Rahme LG. Down-regulation of glutatione S-transferase a 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection. FASEB J. 2012 Feb; 26(2):730-7. PMID: 22038048.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  46. Kesarwani M, Hazan R, He J, Que YA, Que Y, Apidianakis Y, Lesic B, Xiao G, Dekimpe V, Milot S, Deziel E, Lépine F, Rahme LG. A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes. PLoS Pathog. 2011 Aug; 7(8):e1002192. PMID: 21829370.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  47. Que YA, Hazan R, Ryan CM, Milot S, Lépine F, Lydon M, Rahme LG. Production of Pseudomonas aeruginosa Intercellular Small Signaling Molecules in Human Burn Wounds. J Pathog. 2011; 2011:549302. PMID: 23533774.
    Citations: 6     
  48. Astrakas L, Blekas KD, Constantinou C, Andronesi OC, Mindrinos MN, Likas AC, Rahme LG, Black PM, Marcus KJ, Tzika AA. Combining magnetic resonance spectroscopy and molecular genomics offers better accuracy in brain tumor typing and prediction of survival than either methodology alone. Int J Oncol. 2011 Apr; 38(4):1113-27. PMID: 21274507.
    Citations: 3     Fields:    Translation:Humans
  49. Apidianakis Y, Rahme LG. Drosophila melanogaster as a model for human intestinal infection and pathology. Dis Model Mech. 2011 Jan; 4(1):21-30. PMID: 21183483.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  50. Constantinou C, Fontes de Oliveira CC, Mintzopoulos D, Busquets S, He J, Kesarwani M, Mindrinos M, Rahme LG, Argilés JM, Tzika AA. Nuclear magnetic resonance in conjunction with functional genomics suggests mitochondrial dysfunction in a murine model of cancer cachexia. Int J Mol Med. 2011 Jan; 27(1):15-24. PMID: 21069263.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  51. Andronesi OC, Mintzopoulos D, Righi V, Psychogios N, Kesarwani M, He J, Yasuhara S, Dai G, Rahme LG, Tzika AA. Combined off-resonance imaging and T2 relaxation in the rotating frame for positive contrast MR imaging of infection in a murine burn model. J Magn Reson Imaging. 2010 Nov; 32(5):1172-83. PMID: 21031524.
    Citations: 2     Fields:    Translation:AnimalsCells
  52. Righi V, Apidianakis Y, Mintzopoulos D, Astrakas L, Rahme LG, Tzika AA. In vivo high-resolution magic angle spinning magnetic resonance spectroscopy of Drosophila melanogaster at 14.1 T shows trauma in aging and in innate immune-deficiency is linked to reduced insulin signaling. Int J Mol Med. 2010 Aug; 26(2):175-84. PMID: 20596596.
    Citations: 8     Fields:    Translation:AnimalsCells
  53. Zhou B, Xu W, Herndon D, Tompkins R, Davis R, Xiao W, Wong WH, Toner M, Warren HS, Schoenfeld DA, Rahme L, McDonald-Smith GP, Hayden D, Mason P, Fagan S, Yu YM, Cobb JP, Remick DG, Mannick JA, Lederer JA, Gamelli RL, Silver GM, West MA, Shapiro MB, Smith R, Camp DG, Qian W, Storey J, Mindrinos M, Tibshirani R, Lowry S, Calvano S, Chaudry I, West MA, Cohen M, Moore EE, Johnson J, Moldawer LL, Baker HV, Efron PA, Balis UG, Billiar TR, Ochoa JB, Sperry JL, Miller-Graziano CL, De AK, Bankey PE, Finnerty CC, Jeschke MG, Minei JP, Arnoldo BD, Hunt JL, Horton J, Cobb JP, Brownstein B, Freeman B, Maier RV, Nathens AB, Cuschieri J, Gibran N, Klein M, O'Keefe G. Analysis of factorial time-course microarrays with application to a clinical study of burn injury. Proc Natl Acad Sci U S A. 2010 Jun 01; 107(22):9923-8. PMID: 20479259.
    Citations: 27     Fields:    Translation:Humans
  54. Righi V, Apidianakis Y, Rahme LG, Tzika AA. Magnetic resonance spectroscopy of live Drosophila melanogaster using magic angle spinning. J Vis Exp. 2010 Apr 15; (38). PMID: 20395938.
    Citations: 1     Fields:    Translation:Animals
  55. Hazan R, He J, Xiao G, Dekimpe V, Apidianakis Y, Lesic B, Astrakas C, Déziel E, Lépine F, Rahme LG. Homeostatic interplay between bacterial cell-cell signaling and iron in virulence. PLoS Pathog. 2010 Mar 12; 6(3):e1000810. PMID: 20300606.
    Citations: 29     Fields:    Translation:AnimalsCells
  56. Apidianakis Y, Pitsouli C, Perrimon N, Rahme L. Synergy between bacterial infection and genetic predisposition in intestinal dysplasia. Proc Natl Acad Sci U S A. 2009 Dec 08; 106(49):20883-8. PMID: 19934041.
    Citations: 74     Fields:    Translation:AnimalsCells
  57. An D, Apidianakis Y, Boechat AL, Baldini RL, Goumnerov BC, Rahme LG. The pathogenic properties of a novel and conserved gene product, KerV, in proteobacteria. PLoS One. 2009 Sep 25; 4(9):e7167. PMID: 19779606.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  58. Tzika AA, Mintzopoulos D, Mindrinos M, Zhang J, Rahme LG, Tompkins RG. Microarray analysis suggests that burn injury results in mitochondrial dysfunction in human skeletal muscle. Int J Mol Med. 2009 Sep; 24(3):387-92. PMID: 19639232.
    Citations: 13     Fields:    Translation:HumansCells
  59. Rodriguez S, Chora A, Goumnerov B, Mumaw C, Goebel WS, Fernandez L, Baydoun H, HogenEsch H, Dombkowski DM, Karlewicz CA, Rice S, Rahme LG, Carlesso N. Dysfunctional expansion of hematopoietic stem cells and block of myeloid differentiation in lethal sepsis. Blood. 2009 Nov 05; 114(19):4064-76. PMID: 19696201.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  60. Apidianakis Y, Rahme LG. Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa infection. Nat Protoc. 2009; 4(9):1285-94. PMID: 19680242.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  61. Lesic B, Starkey M, He J, Hazan R, Rahme LG. Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesis. Microbiology. 2009 Sep; 155(Pt 9):2845-2855. PMID: 19497948.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  62. Starkey M, Rahme LG. Modeling Pseudomonas aeruginosa pathogenesis in plant hosts. Nat Protoc. 2009; 4(2):117-24. PMID: 19180083.
    Citations: 23     Fields:    Translation:AnimalsCells
  63. Tzika AA, Astrakas LG, Cao H, Mintzopoulos D, Zhang Q, Padfield K, Yu H, Mindrinos MN, Rahme LG, Tompkins RG. Murine intramyocellular lipids quantified by NMR act as metabolic biomarkers in burn trauma. Int J Mol Med. 2008 Jun; 21(6):825-32. PMID: 18506378.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  64. Lesic B, Rahme LG. Use of the lambda Red recombinase system to rapidly generate mutants in Pseudomonas aeruginosa. BMC Mol Biol. 2008 Feb 04; 9:20. PMID: 18248677.
    Citations: 40     Fields:    Translation:Cells
  65. Tzika AA, Mintzopoulos D, Padfield K, Wilhelmy J, Mindrinos MN, Yu H, Cao H, Zhang Q, Astrakas LG, Zhang J, Yu YM, Rahme LG, Tompkins RG. Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn. Int J Mol Med. 2008 Feb; 21(2):201-8. PMID: 18204786.
    Citations: 10     Fields:    Translation:AnimalsCells
  66. Khan N, Mupparaju SP, Mintzopoulos D, Kesarwani M, Righi V, Rahme LG, Swartz HM, Tzika AA. Burn trauma in skeletal muscle results in oxidative stress as assessed by in vivo electron paramagnetic resonance. Mol Med Rep. 2008; 1(6):813-819. PMID: 21179378.
    Citations: 8     Fields:    
  67. Apidianakis Y, Mindrinos MN, Xiao W, Tegos GP, Papisov MI, Hamblin MR, Davis RW, Tompkins RG, Rahme LG. Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma. PLoS One. 2007 Dec 26; 2(12):e1356. PMID: 18159239.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  68. Lesic B, Lépine F, Déziel E, Zhang J, Zhang Q, Padfield K, Castonguay MH, Milot S, Stachel S, Tzika AA, Tompkins RG, Rahme LG. Inhibitors of pathogen intercellular signals as selective anti-infective compounds. PLoS Pathog. 2007 Sep 14; 3(9):1229-39. PMID: 17941706.
    Citations: 52     Fields:    Translation:AnimalsCells
  69. Tzika AA, Astrakas L, Cao H, Mintzopoulos D, Andronesi OC, Mindrinos M, Zhang J, Rahme LG, Blekas KD, Likas AC, Galatsanos NP, Carroll RS, Black PM. Combination of high-resolution magic angle spinning proton magnetic resonance spectroscopy and microscale genomics to type brain tumor biopsies. Int J Mol Med. 2007 Aug; 20(2):199-208. PMID: 17611638.
    Citations: 13     Fields:    Translation:Humans
  70. Lépine F, Dekimpe V, Lesic B, Milot S, Lesimple A, Mamer OA, Rahme LG, Déziel E. PqsA is required for the biosynthesis of 2,4-dihydroxyquinoline (DHQ), a newly identified metabolite produced by Pseudomonas aeruginosa and Burkholderia thailandensis. Biol Chem. 2007 Aug; 388(8):839-45. PMID: 17655503.
    Citations: 14     Fields:    Translation:Cells
  71. Zaborina O, Lepine F, Xiao G, Valuckaite V, Chen Y, Li T, Ciancio M, Zaborin A, Petrof EO, Petroff E, Turner JR, Rahme LG, Chang E, Alverdy JC. Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa. PLoS Pathog. 2007 Mar; 3(3):e35. PMID: 17367209.
    Citations: 64     Fields:    Translation:AnimalsCells
  72. Xiao G, Déziel E, He J, Lépine F, Lesic B, Castonguay MH, Milot S, Tampakaki AP, Stachel SE, Rahme LG. MvfR, a key Pseudomonas aeruginosa pathogenicity LTTR-class regulatory protein, has dual ligands. Mol Microbiol. 2006 Dec; 62(6):1689-99. PMID: 17083468.
    Citations: 83     Fields:    Translation:AnimalsCells
  73. Zhang Q, Cao H, Astrakas LG, Mintzopoulos D, Mindrinos MN, Schulz J, Tompkins RG, Rahme LG, Tzika AA. Uncoupling protein 3 expression and intramyocellular lipid accumulation by NMR following local burn trauma. Int J Mol Med. 2006 Dec; 18(6):1223-9. PMID: 17089030.
    Citations: 5     Fields:    Translation:Animals
  74. Lee DG, Urbach JM, Wu G, Liberati NT, Feinbaum RL, Miyata S, Diggins LT, He J, Saucier M, Déziel E, Friedman L, Li L, Grills G, Montgomery K, Kucherlapati R, Rahme LG, Ausubel FM. Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial. Genome Biol. 2006; 7(10):R90. PMID: 17038190.
    Citations: 164     Fields:    Translation:Cells
  75. Padfield KE, Zhang Q, Gopalan S, Tzika AA, Mindrinos MN, Tompkins RG, Rahme LG. Local and distant burn injury alter immuno-inflammatory gene expression in skeletal muscle. J Trauma. 2006 Aug; 61(2):280-92. PMID: 16917440.
    Citations: 8     Fields:    Translation:Animals
  76. Xiao G, He J, Rahme LG. Mutation analysis of the Pseudomonas aeruginosa mvfR and pqsABCDE gene promoters demonstrates complex quorum-sensing circuitry. Microbiology. 2006 Jun; 152(Pt 6):1679-1686. PMID: 16735731.
    Citations: 52     Fields:    Translation:Cells
  77. Astrakas LG, Goljer I, Yasuhara S, Padfield KE, Zhang Q, Gopalan S, Mindrinos MN, Dai G, Yu YM, Martyn JA, Tompkins RG, Rahme LG, Tzika AA. Proton NMR spectroscopy shows lipids accumulate in skeletal muscle in response to burn trauma-induced apoptosis. FASEB J. 2005 Sep; 19(11):1431-40. PMID: 16126910.
    Citations: 15     Fields:    Translation:Cells
  78. Padfield KE, Astrakas LG, Zhang Q, Gopalan S, Dai G, Mindrinos MN, Tompkins RG, Rahme LG, Tzika AA. Burn injury causes mitochondrial dysfunction in skeletal muscle. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5368-73. PMID: 15809440.
    Citations: 41     Fields:    Translation:AnimalsCells
  79. Cobb JP, Mindrinos MN, Miller-Graziano C, Calvano SE, Baker HV, Xiao W, Laudanski K, Brownstein BH, Elson CM, Hayden DL, Herndon DN, Lowry SF, Maier RV, Schoenfeld DA, Moldawer LL, Davis RW, Tompkins RG, Baker HV, Bankey P, Billiar T, Brownstein BH, Calvano SE, Camp D, Chaudry I, Cobb JP, Davis RW, Elson CM, Freeman B, Gamelli R, Gibran N, Harbrecht B, Hayden DL, Heagy W, Heimbach D, Herndon DN, Horton J, Hunt J, Laudanski K, Lederer J, Lowry SF, Maier RV, Mannick J, McKinley B, Miller-Graziano C, Mindrinos MN, Minei J, Moldawer LL, Moore E, Moore F, Munford R, Nathens A, O'keefe G, Purdue G, Rahme L, Remick D, Sailors M, Schoenfeld DA, Shapiro M, Silver G, Smith R, Stephanopoulos G, Stormo G, Tompkins RG, Toner M, Warren S, West M, Wolfe S, Xiao W, Young V. Application of genome-wide expression analysis to human health and disease. Proc Natl Acad Sci U S A. 2005 Mar 29; 102(13):4801-6. PMID: 15781863.
    Citations: 98     Fields:    Translation:HumansCells
  80. Apidianakis Y, Mindrinos MN, Xiao W, Lau GW, Baldini RL, Davis RW, Rahme LG. Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimicrobial peptide gene expression. Proc Natl Acad Sci U S A. 2005 Feb 15; 102(7):2573-8. PMID: 15695583.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  81. Déziel E, Gopalan S, Tampakaki AP, Lépine F, Padfield KE, Saucier M, Xiao G, Rahme LG. The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing-regulated genes are modulated without affecting lasRI, rhlRI or the production of N-acyl-L-homoserine lactones. Mol Microbiol. 2005 Feb; 55(4):998-1014. PMID: 15686549.
    Citations: 117     Fields:    Translation:AnimalsCells
  82. Lépine F, Milot S, Déziel E, He J, Rahme LG. Electrospray/mass spectrometric identification and analysis of 4-hydroxy-2-alkylquinolines (HAQs) produced by Pseudomonas aeruginosa. J Am Soc Mass Spectrom. 2004 Jun; 15(6):862-9. PMID: 15144975.
    Citations: 69     Fields:    Translation:Cells
  83. Apidianakis Y, Rahme LG, Heitman J, Ausubel FM, Calderwood SB, Mylonakis E. Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response. Eukaryot Cell. 2004 Apr; 3(2):413-9. PMID: 15075271.
    Citations: 50     Fields:    Translation:AnimalsCells
  84. He J, Baldini RL, Déziel E, Saucier M, Zhang Q, Liberati NT, Lee D, Urbach J, Goodman HM, Rahme LG. The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2530-5. PMID: 14983043.
    Citations: 115     Fields:    Translation:AnimalsCells
  85. Déziel E, Lépine F, Milot S, He J, Mindrinos MN, Tompkins RG, Rahme LG. Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication. Proc Natl Acad Sci U S A. 2004 Feb 03; 101(5):1339-44. PMID: 14739337.
    Citations: 142     Fields:    Translation:Cells
  86. Walker TS, Bais HP, Déziel E, Schweizer HP, Rahme LG, Fall R, Vivanco JM. Pseudomonas aeruginosa-plant root interactions. Pathogenicity, biofilm formation, and root exudation. Plant Physiol. 2004 Jan; 134(1):320-31. PMID: 14701912.
    Citations: 45     Fields:    Translation:AnimalsCells
  87. Lau GW, Goumnerov BC, Walendziewicz CL, Hewitson J, Xiao W, Mahajan-Miklos S, Tompkins RG, Perkins LA, Rahme LG. The Drosophila melanogaster toll pathway participates in resistance to infection by the gram-negative human pathogen Pseudomonas aeruginosa. Infect Immun. 2003 Jul; 71(7):4059-66. PMID: 12819096.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  88. Lépine F, Déziel E, Milot S, Rahme LG. A stable isotope dilution assay for the quantification of the Pseudomonas quinolone signal in Pseudomonas aeruginosa cultures. Biochim Biophys Acta. 2003 Jun 20; 1622(1):36-41. PMID: 12829259.
    Citations: 46     Fields:    Translation:Cells
  89. Choi JY, Sifri CD, Goumnerov BC, Rahme LG, Ausubel FM, Calderwood SB. Identification of virulence genes in a pathogenic strain of Pseudomonas aeruginosa by representational difference analysis. J Bacteriol. 2002 Feb; 184(4):952-61. PMID: 11807055.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  90. Baldini RL, Lau GW, Rahme LG. Use of plant and insect hosts to model bacterial pathogenesis. Methods Enzymol. 2002; 358:3-13. PMID: 12474375.
    Citations: 5     Fields:    Translation:AnimalsCells
  91. Hendrickson EL, Plotnikova J, Mahajan-Miklos S, Rahme LG, Ausubel FM. Differential roles of the Pseudomonas aeruginosa PA14 rpoN gene in pathogenicity in plants, nematodes, insects, and mice. J Bacteriol. 2001 Dec; 183(24):7126-34. PMID: 11717271.
    Citations: 38     Fields:    Translation:AnimalsCells
  92. Cao H, Krishnan G, Goumnerov B, Tsongalis J, Tompkins R, Rahme LG. A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism. Proc Natl Acad Sci U S A. 2001 Dec 04; 98(25):14613-8. PMID: 11724939.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  93. Yorgey P, Rahme LG, Tan MW, Ausubel FM. The roles of mucD and alginate in the virulence of Pseudomonas aeruginosa in plants, nematodes and mice. Mol Microbiol. 2001 Sep; 41(5):1063-76. PMID: 11555287.
    Citations: 25     Fields:    Translation:AnimalsCells
  94. Cao H, Baldini RL, Rahme LG. Common mechanisms for pathogens of plants and animals. Annu Rev Phytopathol. 2001; 39:259-84. PMID: 11701866.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  95. Plotnikova JM, Rahme LG, Ausubel FM. Pathogenesis of the human opportunistic pathogen Pseudomonas aeruginosa PA14 in Arabidopsis. Plant Physiol. 2000 Dec; 124(4):1766-74. PMID: 11115892.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  96. Mahajan-Miklos S, Rahme LG, Ausubel FM. Elucidating the molecular mechanisms of bacterial virulence using non-mammalian hosts. Mol Microbiol. 2000 Sep; 37(5):981-8. PMID: 10972817.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  97. Rahme LG, Ausubel FM, Cao H, Drenkard E, Goumnerov BC, Lau GW, Mahajan-Miklos S, Plotnikova J, Tan MW, Tsongalis J, Walendziewicz CL, Tompkins RG. Plants and animals share functionally common bacterial virulence factors. Proc Natl Acad Sci U S A. 2000 Aug 01; 97(16):8815-21. PMID: 10922040.
    Citations: 119     Fields:    Translation:AnimalsCells
  98. Jander G, Rahme LG, Ausubel FM. Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects. J Bacteriol. 2000 Jul; 182(13):3843-5. PMID: 10851003.
    Citations: 158     Fields:    Translation:HumansAnimalsCells
  99. Tan MW, Rahme LG, Sternberg JA, Tompkins RG, Ausubel FM. Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2408-13. PMID: 10051655.
    Citations: 186     Fields:    Translation:HumansAnimalsCells
  100. Mahajan-Miklos S, Tan MW, Rahme LG, Ausubel FM. Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model. Cell. 1999 Jan 08; 96(1):47-56. PMID: 9989496.
    Citations: 233     Fields:    Translation:HumansAnimalsCells
  101. Wong SM, Carroll PA, Rahme LG, Ausubel FM, Calderwood SB. Modulation of expression of the ToxR regulon in Vibrio cholerae by a member of the two-component family of response regulators. Infect Immun. 1998 Dec; 66(12):5854-61. PMID: 9826365.
    Citations: 24     Fields:    Translation:AnimalsCells
  102. Rahme LG, Tan MW, Le L, Wong SM, Tompkins RG, Calderwood SB, Ausubel FM. Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):13245-50. PMID: 9371831.
    Citations: 105     Fields:    Translation:AnimalsCells
  103. Rahme LG, Stevens EJ, Wolfort SF, Shao J, Tompkins RG, Ausubel FM. Common virulence factors for bacterial pathogenicity in plants and animals. Science. 1995 Jun 30; 268(5219):1899-902. PMID: 7604262.
    Citations: 430     Fields:    Translation:AnimalsCells
  104. Rahme LG, Mindrinos MN, Panopoulos NJ. Plant and environmental sensory signals control the expression of hrp genes in Pseudomonas syringae pv. phaseolicola. J Bacteriol. 1992 Jun; 174(11):3499-507. PMID: 1592805.
    Citations: 46     Fields:    Translation:AnimalsCells
  105. Rahme LG, Mindrinos MN, Panopoulos NJ. Genetic and transcriptional organization of the hrp cluster of Pseudomonas syringae pv. phaseolicola. J Bacteriol. 1991 Jan; 173(2):575-86. PMID: 1846144.
    Citations: 32     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.