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Patricia Leonor Musolino, M.D.,Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS117575 (MUSOLINO, PATRICIA LEONOR) Sep 1, 2020 - Jun 30, 2025
    NIH
    Effects of ABCD1 deficiency on endothelial function and permeability to leukocytes in Cerebral X-linked Adrenoleukodystrophy
    Role: Principal Investigator
  2. K08NS094683 (MUSOLINO, PATRICIA LEONOR) Sep 30, 2015 - Jun 30, 2021
    NIH
    Effect of ABCD1 upon Brain Endothelium in X-linked Adrenoleukodystrophy
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rodríguez-Pascau L, Vilalta A, Cerrada M, Traver E, Forss-Petter S, Weinhofer I, Bauer J, Kemp S, Pina G, Pascual S, Meya U, Musolino PL, Berger J, Martinell M, Pizcueta P. The brain penetrant PPAR? agonist leriglitazone restores multiple altered pathways in models of X-linked adrenoleukodystrophy. Sci Transl Med. 2021 Jun 02; 13(596). PMID: 34078742.
    Citations:    Fields:    
  2. Weinhofer I, Rommer P, Zierfuss B, Altmann P, Foiani M, Heslegrave A, Zetterberg H, Gleiss A, Musolino PL, Gong Y, Forss-Petter S, Berger T, Eichler F, Aubourg P, Köhler W, Berger J. Neurofilament light chain as a potential biomarker for monitoring neurodegeneration in X-linked adrenoleukodystrophy. Nat Commun. 2021 03 22; 12(1):1816. PMID: 33753741.
    Citations:    Fields:    Translation:HumansCells
  3. Lauer A, Speroni SL, Patel JB, Regalado E, Choi M, Smith E, Kalpathy-Kramer J, Caruso P, Milewicz DM, Musolino PL. Cerebrovascular Disease Progression in Patients With ACTA2 Arg179 Pathogenic Variants. Neurology. 2021 01 26; 96(4):e538-e552. PMID: 33199432.
    Citations:    Fields:    Translation:Humans
  4. Sporns PB, Psychogios MN, Straeter R, Hanning U, Minnerup J, Chapot R, Henkes H, Henkes E, Grams A, Dorn F, Nikoubashman O, Wiesmann M, Bier G, Weber A, Broocks G, Fiehler J, Brehm A, Kaiser D, Yilmaz U, Morotti A, Marik W, Nolz R, Jensen-Kondering U, Braun M, Schob S, Beuing O, Goetz F, Trenkler J, Turowski B, Möhlenbruch M, Wendl C, Schramm P, Musolino PL, Lee S, Schlamann M, Radbruch A, Karch A, Rübsamen N, Wildgruber M, Kemmling A. Clinical Diffusion Mismatch to Select Pediatric Patients for Embolectomy 6 to 24 Hours After Stroke: An Analysis of the Save ChildS Study. Neurology. 2021 01 19; 96(3):e343-e351. PMID: 33144517.
    Citations: 1     Fields:    Translation:Humans
  5. Mallack EJ, van de Stadt S, Caruso PA, Musolino PL, Sadjadi R, Engelen M, Eichler FS. Clinical and radiographic course of arrested cerebral adrenoleukodystrophy. Neurology. 2020 06 16; 94(24):e2499-e2507. PMID: 32482842.
    Citations: 1     Fields:    Translation:Humans
  6. Sporns PB, Straeter R, Minnerup J, Wiendl H, Hanning U, Chapot R, Henkes H, Henkes E, Grams A, Dorn F, Nikoubashman O, Wiesmann M, Bier G, Weber A, Broocks G, Fiehler J, Brehm A, Psychogios M, Kaiser D, Yilmaz U, Morotti A, Marik W, Nolz R, Jensen-Kondering U, Schmitz B, Schob S, Beuing O, Goetz F, Trenkler J, Turowski B, Möhlenbruch M, Wendl C, Schramm P, Musolino P, Lee S, Schlamann M, Radbruch A, Rübsamen N, Karch A, Heindel W, Wildgruber M, Kemmling A. Does Device Selection Impact Recanalization Rate and Neurological Outcome?: An Analysis of the Save ChildS Study. Stroke. 2020 04; 51(4):1182-1189. PMID: 32114927.
    Citations: 1     Fields:    Translation:Humans
  7. Sporns PB, Sträter R, Minnerup J, Wiendl H, Hanning U, Chapot R, Henkes H, Henkes E, Grams A, Dorn F, Nikoubashman O, Wiesmann M, Bier G, Weber A, Broocks G, Fiehler J, Brehm A, Psychogios M, Kaiser D, Yilmaz U, Morotti A, Marik W, Nolz R, Jensen-Kondering U, Schmitz B, Schob S, Beuing O, Götz F, Trenkler J, Turowski B, Möhlenbruch M, Wendl C, Schramm P, Musolino P, Lee S, Schlamann M, Radbruch A, Rübsamen N, Karch A, Heindel W, Wildgruber M, Kemmling A. Feasibility, Safety, and Outcome of Endovascular Recanalization in Childhood Stroke: The Save ChildS Study. JAMA Neurol. 2020 01 01; 77(1):25-34. PMID: 31609380.
    Citations: 6     Fields:    Translation:Humans
  8. Liberato AP, Mallack EJ, Aziz-Bose R, Hayden D, Lauer A, Caruso PA, Musolino PL, Eichler FS. MRI brain lesions in asymptomatic boys with X-linked adrenoleukodystrophy. Neurology. 2019 04 09; 92(15):e1698-e1708. PMID: 30902905.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  9. Regalado ES, Mellor-Crummey L, De Backer J, Braverman AC, Ades L, Benedict S, Bradley TJ, Brickner ME, Chatfield KC, Child A, Feist C, Holmes KW, Iannucci G, Lorenz B, Mark P, Morisaki T, Morisaki H, Morris SA, Mitchell AL, Ostergaard JR, Richer J, Sallee D, Shalhub S, Tekin M, Estrera A, Musolino P, Yetman A, Pyeritz R, Milewicz DM. Clinical history and management recommendations of the smooth muscle dysfunction syndrome due to ACTA2 arginine 179 alterations. Genet Med. 2018 10; 20(10):1206-1215. PMID: 29300374.
    Citations: 9     Fields:    Translation:Humans
  10. Lauer A, Da X, Hansen MB, Boulouis G, Ou Y, Cai X, Liberato Celso Pedrotti A, Kalpathy-Cramer J, Caruso P, Hayden DL, Rost N, Mouridsen K, Eichler FS, Rosen B, Musolino PL. ABCD1 dysfunction alters white matter microvascular perfusion. Brain. 2017 Dec 01; 140(12):3139-3152. PMID: 29136088.
    Citations: 5     Fields:    Translation:Humans
  11. Gong Y, Sasidharan N, Laheji F, Frosch M, Musolino P, Tanzi R, Kim DY, Biffi A, El Khoury J, Eichler F. Microglial dysfunction as a key pathological change in adrenomyeloneuropathy. Ann Neurol. 2017 Nov; 82(5):813-827. PMID: 29059709.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  12. Eichler F, Duncan C, Musolino PL, Orchard PJ, De Oliveira S, Thrasher AJ, Armant M, Dansereau C, Lund TC, Miller WP, Raymond GV, Sankar R, Shah AJ, Sevin C, Gaspar HB, Gissen P, Amartino H, Bratkovic D, Smith NJC, Paker AM, Shamir E, O'Meara T, Davidson D, Aubourg P, Williams DA. Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy. N Engl J Med. 2017 10 26; 377(17):1630-1638. PMID: 28976817.
    Citations: 82     Fields:    Translation:HumansCellsCTClinical Trials
  13. Rost NS, Cougo P, Lorenzano S, Li H, Cloonan L, Bouts MJ, Lauer A, Etherton MR, Karadeli HH, Musolino PL, Copen WA, Arai K, Lo EH, Feske SK, Furie KL, Wu O. Diffuse microvascular dysfunction and loss of white matter integrity predict poor outcomes in patients with acute ischemic stroke. J Cereb Blood Flow Metab. 2018 01; 38(1):75-86. PMID: 28481164.
    Citations: 17     Fields:    Translation:Humans
  14. Bevers MB, McGuone D, Jerath NU, Musolino PL. Leptomeningeal transthyretin-type amyloidosis presenting as acute hydrocephalus and subarachnoid hemorrhage. J Clin Neurosci. 2016 Jul; 29:203-5. PMID: 26896372.
    Citations: 1     Fields:    Translation:Humans
  15. Musolino PL, Gong Y, Snyder JM, Jimenez S, Lok J, Lo EH, Moser AB, Grabowski EF, Frosch MP, Eichler FS. Brain endothelial dysfunction in cerebral adrenoleukodystrophy. Brain. 2015 Nov; 138(Pt 11):3206-20. PMID: 26377633.
    Citations: 23     Fields:    Translation:HumansCells
  16. Gong Y, Mu D, Prabhakar S, Moser A, Musolino P, Ren J, Breakefield XO, Maguire CA, Eichler FS. Adenoassociated virus serotype 9-mediated gene therapy for x-linked adrenoleukodystrophy. Mol Ther. 2015 May; 23(5):824-834. PMID: 25592337.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  17. Musolino PL, Lund TC, Pan J, Escolar ML, Paker AM, Duncan CN, Eichler FS. Hematopoietic stem cell transplantation in the leukodystrophies: a systematic review of the literature. Neuropediatrics. 2014 Jun; 45(3):e1. PMID: 24515842.
    Citations:    
  18. Musolino PL, Lund TC, Pan J, Escolar ML, Paker AM, Duncan CN, Eichler FS. Hematopoietic stem cell transplantation in the leukodystrophies: a systematic review of the literature. Neuropediatrics. 2014 Jun; 45(3):169-74. PMID: 24459069.
    Citations: 8     Fields:    Translation:Humans
  19. Musolino PL, Rapalino O, Caruso P, Caviness VS, Eichler FS. Hypoperfusion predicts lesion progression in cerebral X-linked adrenoleukodystrophy. Brain. 2012 Sep; 135(Pt 9):2676-83. PMID: 22961546.
    Citations: 16     Fields:    Translation:HumansCells
  20. Coronel MF, Musolino PL, Brumovsky PR, Hökfelt T, Villar MJ. Bone marrow stromal cells attenuate injury-induced changes in galanin, NPY and NPY Y1-receptor expression after a sciatic nerve constriction. Neuropeptides. 2009 Apr; 43(2):125-32. PMID: 19168218.
    Citations: 7     Fields:    Translation:AnimalsCells
  21. Carranza A, Musolino PL, Villar M, Nowicki S. Signaling cascade of insulin-induced stimulation of L-dopa uptake in renal proximal tubule cells. . 2008 Dec; 295(6):C1602-9. PMID: 18842830.
    Citations: 8     Translation:AnimalsCells
  22. Musolino PL, Coronel MF, Hökfelt T, Villar MJ. Bone marrow stromal cells induce changes in pain behavior after sciatic nerve constriction. Neurosci Lett. 2007 May 11; 418(1):97-101. PMID: 17379405.
    Citations: 22     Fields:    Translation:AnimalsCells
  23. Setton-Avruj CP, Musolino PL, Salis C, Alló M, Bizzozero O, Villar MJ, Soto EF, Pasquini JM. Presence of alpha-globin mRNA and migration of bone marrow cells after sciatic nerve injury suggests their participation in the degeneration/regeneration process. Exp Neurol. 2007 Feb; 203(2):568-78. PMID: 17126834.
    Citations: 7     Fields:    Translation:AnimalsCells
  24. Aquino JB, Musolino PL, Coronel MF, Villar MJ, Setton-Avruj CP. Nerve degeneration is prevented by a single intraneural apotransferrin injection into colchicine-injured sciatic nerves in the rat. Brain Res. 2006 Oct 30; 1117(1):80-91. PMID: 17010319.
    Citations: 4     Fields:    Translation:AnimalsCells
  25. Bendersky M, Musolino PL, Rugilo C, Schuster G, Sica RE. Normal anatomy of the developing fetal brain. Ex vivo anatomical-magnetic resonance imaging correlation. J Neurol Sci. 2006 Dec 01; 250(1-2):20-6. PMID: 16905152.
    Citations: 14     Fields:    Translation:Humans
  26. Coronel MF, Musolino PL, Villar MJ. Selective migration and engraftment of bone marrow mesenchymal stem cells in rat lumbar dorsal root ganglia after sciatic nerve constriction. Neurosci Lett. 2006 Sep 11; 405(1-2):5-9. PMID: 16806704.
    Citations: 9     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.