Harvard Catalyst Profiles

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Jeffrey Scott Flier, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. G20RR032445 (FLIER, JEFFREY S) Sep 22, 2011 - Sep 21, 2013
    NIH/NCRR
    Nonhuman Primate Housing Infrastructure and Caging
    Role: Principal Investigator
  2. R13DK058917 (FLIER, JEFFREY S) Jan 1, 2001 - Dec 31, 2001
    NIH/NIDDK
    OBESITY AND REGULATION OF ENERGY HOMEOSTASIS
    Role: Principal Investigator
  3. P01DK056116 (KAHN, BARBARA B) Aug 1, 1999 - Mar 31, 2012
    NIH/NIDDK
    Peripheral and Central Interactions in Energy Balance
    Role: Co-Principal Investigator
  4. P51OD011103 (FLIER, JEFFREY S) May 1, 1997 - Apr 30, 2014
    NIH
    New England Primate Research Center Base Grant
    Role: Principal Investigator
  5. R01DK046930 (FLIER, JEFFREY S) Aug 1, 1993 - Jul 31, 2003
    NIH/NIDDK
    BROWN FAT AND THE CENTRAL CONTROL OF ENERGY BALANCE
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Flier JS. Starvation in the Midst of Plenty: Reflections on the History and Biology of Insulin and Leptin. Endocr Rev. 2019 02 01; 40(1):1-16. PMID: 30357355.
    Citations:    Fields:    
  2. Singhal G, Kumar G, Chan S, Fisher FM, Ma Y, Vardeh HG, Nasser IA, Flier JS, Maratos-Flier E. Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet. Mol Metab. 2018 Jul; 13:56-66. PMID: 29753678.
    Citations:    Fields:    
  3. Glass DJ, Flier JS. Dealing with Consequences of Irreproducibility and Modifying the Published Literature: Retractions versus Revisions. Cell Metab. 2017 Nov 07; 26(5):695-696. PMID: 29117541.
    Citations:    Fields:    
  4. Flier J. Faculty promotion must assess reproducibility. Nature. 2017 09 12; 549(7671):133. PMID: 28905925.
    Citations: 1     Fields:    Translation:HumansAnimals
  5. Desai BN, Singhal G, Watanabe M, Stevanovic D, Lundasen T, Fisher FM, Mather ML, Vardeh HG, Douris N, Adams AC, Nasser IA, FitzGerald GA, Flier JS, Skarke C, Maratos-Flier E. Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury. Mol Metab. 2017 11; 6(11):1395-1406. PMID: 29107287.
    Citations: 7     Fields:    Translation:HumansAnimals
  6. Flier JS, Loscalzo J. Categorizing biomedical research: the basics of translation. FASEB J. 2017 08; 31(8):3210-3215. PMID: 28765169.
    Citations:    Fields:    Translation:HumansAnimals
  7. Flier JS, Maratos-Flier E. Leptin's Physiologic Role: Does the Emperor of Energy Balance Have No Clothes? Cell Metab. 2017 Jul 05; 26(1):24-26. PMID: 28648981.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  8. Douris N, Desai BN, Fisher FM, Cisu T, Fowler AJ, Zarebidaki E, Nguyen NLT, Morgan DA, Bartness TJ, Rahmouni K, Flier JS, Maratos-Flier E. Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice. Mol Metab. 2017 08; 6(8):854-862. PMID: 28752049.
    Citations:    
  9. Bharel M, Antman K, Berman H, Dimitri D, Flier J, Flotte T. In Reply to Manion and Khan. Acad Med. 2017 06; 92(6):725-726. PMID: 28557909.
    Citations:    Fields:    
  10. Flier JS. Conflict of Interest Among Medical School Faculty: Achieving a Coherent and Objective Approach. JAMA. 2017 May 02; 317(17):1731-1732. PMID: 28464148.
    Citations:    Fields:    Translation:Humans
  11. Flier JS. Irreproducibility of published bioscience research: Diagnosis, pathogenesis and therapy. Mol Metab. 2017 01; 6(1):2-9. PMID: 28123930.
    Citations: 6     Fields:    Translation:HumansAnimals
  12. Antman KH, Berman HA, Flotte TR, Flier J, Dimitri DM, Bharel M. Developing Core Competencies for the Prevention and Management of Prescription Drug Misuse: A Medical Education Collaboration in Massachusetts. Acad Med. 2016 Oct; 91(10):1348-1351. PMID: 27532868.
    Citations: 5     Fields:    
  13. Singhal G, Douris N, Fish AJ, Zhang X, Adams AC, Flier JS, Pissios P, Maratos-Flier E. Fibroblast growth factor 21 has no direct role in regulating fertility in female mice. Mol Metab. 2016 Aug; 5(8):690-698. PMID: 27656406.
    Citations:    Fields:    
  14. Singhal G, Fisher FM, Chee MJ, Tan TG, El Ouaamari A, Adams AC, Najarian R, Kulkarni RN, Benoist C, Flier JS, Maratos-Flier E. Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas. PLoS One. 2016; 11(2):e0148252. PMID: 26872145.
    Citations: 10     Fields:    Translation:AnimalsCells
  15. Douris N, Melman T, Pecherer JM, Pissios P, Flier JS, Cantley LC, Locasale JW, Maratos-Flier E. Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet. Biochim Biophys Acta. 2015 Oct; 1852(10 Pt A):2056-65. PMID: 26170063.
    Citations: 13     Fields:    
  16. Douris N, Stevanovic DM, Fisher FM, Cisu TI, Chee MJ, Nguyen NL, Zarebidaki E, Adams AC, Kharitonenkov A, Flier JS, Bartness TJ, Maratos-Flier E. Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice. Endocrinology. 2015 Jul; 156(7):2470-81. PMID: 25924103; PMCID: PMC4475718.
    Citations: 32     Fields:    Translation:AnimalsCells
  17. Fisher FM, Chui PC, Nasser IA, Popov Y, Cunniff JC, Lundasen T, Kharitonenkov A, Schuppan D, Flier JS, Maratos-Flier E. Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets. Gastroenterology. 2014 Nov; 147(5):1073-83.e6. PMID: 25083607.
    Citations: 43     Fields:    Translation:AnimalsCells
  18. Lo JC, Ljubicic S, Leibiger B, Kern M, Leibiger IB, Moede T, Kelly ME, Chatterjee Bhowmick D, Murano I, Cohen P, Banks AS, Khandekar MJ, Dietrich A, Flier JS, Cinti S, Blüher M, Danial NN, Berggren PO, Spiegelman BM. Adipsin is an adipokine that improves ß cell function in diabetes. Cell. 2014 Jul 03; 158(1):41-53. PMID: 24995977.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  19. Domouzoglou EM, Fisher FM, Astapova I, Fox EC, Kharitonenkov A, Flier JS, Hollenberg AN, Maratos-Flier E. Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo. Endocrinology. 2014 May; 155(5):2031-40. PMID: 24564398; PMCID: PMC3990851.
    Citations: 3     Fields:    Translation:Animals
  20. Flier JS. Creating a Nobel culture. Science. 2013 Jan 11; 339(6116):140-1. PMID: 23307720.
    Citations: 3     Fields:    
  21. Robins SC, Stewart I, McNay DE, Taylor V, Giachino C, Goetz M, Ninkovic J, Briancon N, Maratos-Flier E, Flier JS, Kokoeva MV, Placzek M. a-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors. Nat Commun. 2013; 4:2049. PMID: 23804023.
    Citations: 62     Fields:    Translation:AnimalsCells
  22. Flier JS. Hormone resistance in diabetes and obesity: insulin, leptin, and FGF21. Yale J Biol Med. 2012 Sep; 85(3):405-14. PMID: 23012588; PMCID: PMC3447204.
    Citations: 5     Fields:    Translation:HumansAnimals
  23. Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM. FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 2012 Feb 01; 26(3):271-81. PMID: 22302939; PMCID: PMC3278894.
    Citations: 352     Fields:    Translation:AnimalsCells
  24. McNay DE, Briançon N, Kokoeva MV, Maratos-Flier E, Flier JS. Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. J Clin Invest. 2012 Jan; 122(1):142-52. PMID: 22201680; PMCID: PMC3248278.
    Citations: 81     Fields:    Translation:AnimalsCells
  25. Czupryn A, Zhou YD, Chen X, McNay D, Anderson MP, Flier JS, Macklis JD. Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice. Science. 2011 Nov 25; 334(6059):1133-7. PMID: 22116886; PMCID: PMC3770458.
    Citations: 17     Fields:    Translation:AnimalsCells
  26. Fisher FM, Estall JL, Adams AC, Antonellis PJ, Bina HA, Flier JS, Kharitonenkov A, Spiegelman BM, Maratos-Flier E. Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology. 2011 Aug; 152(8):2996-3004. PMID: 21712364; PMCID: PMC3138239.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  27. Aboulaich N, Chui PC, Asara JM, Flier JS, Maratos-Flier E. Polymerase I and transcript release factor regulates lipolysis via a phosphorylation-dependent mechanism. Diabetes. 2011 Mar; 60(3):757-65. PMID: 21282370; PMCID: PMC3046836.
    Citations: 18     Fields:    Translation:AnimalsCells
  28. Flier JS, Maratos-Flier E. Lasker lauds leptin. Cell Metab. 2010 Oct 06; 12(4):317-320. PMID: 20889124.
    Citations:    Fields:    
  29. Flier JS, Maratos-Flier E. Lasker lauds leptin. Cell. 2010 Oct 01; 143(1):9-12. PMID: 20887884.
    Citations: 6     Fields:    Translation:Humans
  30. Briancon N, McNay DE, Maratos-Flier E, Flier JS. Combined neural inactivation of suppressor of cytokine signaling-3 and protein-tyrosine phosphatase-1B reveals additive, synergistic, and factor-specific roles in the regulation of body energy balance. Diabetes. 2010 Dec; 59(12):3074-84. PMID: 20876718; PMCID: PMC2992768.
    Citations: 20     Fields:    Translation:Animals
  31. Fisher FM, Chui PC, Antonellis PJ, Bina HA, Kharitonenkov A, Flier JS, Maratos-Flier E. Obesity is a fibroblast growth factor 21 (FGF21)-resistant state. Diabetes. 2010 Nov; 59(11):2781-9. PMID: 20682689; PMCID: PMC2963536.
    Citations: 164     Fields:    Translation:HumansAnimalsCells
  32. Adams AC, Astapova I, Fisher FM, Badman MK, Kurgansky KE, Flier JS, Hollenberg AN, Maratos-Flier E. Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner. J Biol Chem. 2010 May 07; 285(19):14078-82. PMID: 20236931; PMCID: PMC2863226.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  33. Nesse RM, Bergstrom CT, Ellison PT, Flier JS, Gluckman P, Govindaraju DR, Niethammer D, Omenn GS, Perlman RL, Schwartz MD, Thomas MG, Stearns SC, Valle D. Evolution in health and medicine Sackler colloquium: Making evolutionary biology a basic science for medicine. Proc Natl Acad Sci U S A. 2010 Jan 26; 107 Suppl 1:1800-7. PMID: 19918069; PMCID: PMC2868284.
    Citations: 37     Fields:    Translation:Humans
  34. Flier JS, Mekalanos JJ. Gut check: testing a role for the intestinal microbiome in human obesity. Sci Transl Med. 2009 Nov 11; 1(6):6ps7. PMID: 20368177.
    Citations: 8     Fields:    Translation:HumansAnimals
  35. Badman MK, Koester A, Flier JS, Kharitonenkov A, Maratos-Flier E. Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. Endocrinology. 2009 Nov; 150(11):4931-40. PMID: 19819944; PMCID: PMC2775979.
    Citations: 116     Fields:    Translation:HumansAnimals
  36. Flier JS. Health care reform: without a correct diagnosis, there is no cure. J Clin Invest. 2009 Oct; 119(10):2850-2. PMID: 20069708; PMCID: PMC2752105.
    Citations: 1     Fields:    Translation:Humans
  37. Kienesberger PC, Lee D, Pulinilkunnil T, Brenner DS, Cai L, Magnes C, Koefeler HC, Streith IE, Rechberger GN, Haemmerle G, Flier JS, Zechner R, Kim YB, Kershaw EE. Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling. J Biol Chem. 2009 Oct 30; 284(44):30218-29. PMID: 19723629; PMCID: PMC2781577.
    Citations: 53     Fields:    Translation:AnimalsCells
  38. Zhang R, Maratos-Flier E, Flier JS. Reduced adiposity and high-fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B. Endocrinology. 2009 Jul; 150(7):3076-82. PMID: 19359377; PMCID: PMC2703511.
    Citations: 17     Fields:    Translation:AnimalsCells
  39. Koulmanda M, Bhasin M, Hoffman L, Fan Z, Qipo A, Shi H, Bonner-Weir S, Putheti P, Degauque N, Libermann TA, Auchincloss H, Flier JS, Strom TB. Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A. 2008 Oct 21; 105(42):16242-7. PMID: 18852471; PMCID: PMC2570971.
    Citations: 67     Fields:    Translation:AnimalsCells
  40. Zhang R, Dhillon H, Yin H, Yoshimura A, Lowell BB, Maratos-Flier E, Flier JS. Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology. 2008 Nov; 149(11):5654-61. PMID: 18669597; PMCID: PMC2584592.
    Citations: 41     Fields:    Translation:AnimalsCells
  41. Kokoeva MV, Yin H, Flier JS. Evidence for constitutive neural cell proliferation in the adult murine hypothalamus. J Comp Neurol. 2007 Nov 10; 505(2):209-20. PMID: 17853440.
    Citations: 73     Fields:    Translation:AnimalsCells
  42. Kershaw EE, Schupp M, Guan HP, Gardner NP, Lazar MA, Flier JS. PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1736-45. PMID: 17848638; PMCID: PMC2819189.
    Citations: 62     Fields:    Translation:AnimalsCells
  43. Flier JS, Maratos-Flier E. What fuels fat. Sci Am. 2007 Sep; 297(3):72-81. PMID: 17784627.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  44. Koulmanda M, Budo E, Bonner-Weir S, Qipo A, Putheti P, Degauque N, Shi H, Fan Z, Flier JS, Auchincloss H, Zheng XX, Strom TB. Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Proc Natl Acad Sci U S A. 2007 Aug 07; 104(32):13074-9. PMID: 17670937; PMCID: PMC1941818.
    Citations: 33     Fields:    Translation:AnimalsCells
  45. Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 2007 Jun; 5(6):426-37. PMID: 17550778.
    Citations: 415     Fields:    Translation:AnimalsCells
  46. Inouye KE, Shi H, Howard JK, Daly CH, Lord GM, Rollins BJ, Flier JS. Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes. 2007 Sep; 56(9):2242-50. PMID: 17473219.
    Citations: 86     Fields:    Translation:AnimalsCells
  47. Badman MK, Flier JS. The adipocyte as an active participant in energy balance and metabolism. Gastroenterology. 2007 May; 132(6):2103-15. PMID: 17498506.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  48. Cheung KJ, Tzameli I, Pissios P, Rovira I, Gavrilova O, Ohtsubo T, Chen Z, Finkel T, Flier JS, Friedman JM. Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity. Cell Metab. 2007 Feb; 5(2):115-28. PMID: 17276354.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  49. Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006 Nov; 116(11):3015-25. PMID: 17053832; PMCID: PMC1616196.
    Citations: 943     Fields:    Translation:HumansAnimalsCells
  50. Howard JK, Flier JS. Attenuation of leptin and insulin signaling by SOCS proteins. Trends Endocrinol Metab. 2006 Nov; 17(9):365-71. PMID: 17010638.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  51. Fulton S, Pissios P, Manchon RP, Stiles L, Frank L, Pothos EN, Maratos-Flier E, Flier JS. Leptin regulation of the mesoaccumbens dopamine pathway. Neuron. 2006 Sep 21; 51(6):811-22. PMID: 16982425.
    Citations: 211     Fields:    Translation:AnimalsCells
  52. Kievit P, Howard JK, Badman MK, Balthasar N, Coppari R, Mori H, Lee CE, Elmquist JK, Yoshimura A, Flier JS. Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells. Cell Metab. 2006 Aug; 4(2):123-32. PMID: 16890540.
    Citations: 85     Fields:    Translation:AnimalsCells
  53. Flier JS. Neuroscience. Regulating energy balance: the substrate strikes back. Science. 2006 May 12; 312(5775):861-4. PMID: 16690851.
    Citations: 17     Fields:    Translation:AnimalsCells
  54. Shi H, C