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profileRichard Neil Channick, M.D.

TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
BUL-148, Pulmonary & Critical Care
55 Fruit St
Boston MA 02114
Phone617/724-3705
Fax617/724-1792
vCardDownload vCard (login for email)

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gaine S, Chin K, Coghlan G, Channick R, Di Scala L, Galiè N, Ghofrani HA, Lang IM, McLaughlin V, Preiss R, Rubin LJ, Simonneau G, Sitbon O, Tapson VF, Hoeper MM. Selexipag for the treatment of connective tissue disease-associated pulmonary arterial hypertension. Eur Respir J. 2017 Aug; 50(2). PMID: 28818881.
    View in: PubMed
  2. DuBrock HM, Goldberg DS, Sussman NL, Bartolome SD, Kadry Z, Salgia RJ, Mulligan DC, Kremers WK, Kawut SM, Krowka MJ, Channick RN. Predictors of Waitlist Mortality in Portopulmonary Hypertension. Transplantation. 2017 Jul; 101(7):1609-1615. PMID: 28207639.
    View in: PubMed
  3. Galiè N, Jansa P, Pulido T, Channick RN, Delcroix M, Ghofrani HA, Le Brun FO, Mehta S, Perchenet L, Rubin LJ, Sastry BKS, Simonneau G, Sitbon O, Souza R, Torbicki A. SERAPHIN haemodynamic substudy: the effect of the dual endothelin receptor antagonist macitentan on haemodynamic parameters and NT-proBNP levels and their association with disease progression in patients with pulmonary arterial hypertension. Eur Heart J. 2017 Apr 14; 38(15):1147-1155. PMID: 28329315.
    View in: PubMed
  4. Rodriguez-Lopez J, Channick R. The Pulmonary Embolism Response Team: What Is the Ideal Model? Semin Respir Crit Care Med. 2017 Feb; 38(1):51-55. PMID: 28208198.
    View in: PubMed
  5. Jain CC, Chang Y, Kabrhel C, Giri J, Channick R, Rodriguez-Lopez J, Rosovsky RP, Fogerty A, Rosenfield K, Jaff MR, Weinberg I. Impact of Pulmonary Arterial Clot Location on Pulmonary Embolism Treatment and Outcomes (90 Days). Am J Cardiol. 2017 Mar 01; 119(5):802-807. PMID: 28153347.
    View in: PubMed
  6. DuBrock HM, Rodriguez-Lopez JM, LeVarge BL, Curry MP, VanderLaan PA, Zsengeller ZK, Pernicone E, Preston IR, Yu PB, Nikolic I, Xu D, Thadhani RI, Channick RN, Ananth Karumanchi S. Macrophage migration inhibitory factor as a novel biomarker of portopulmonary hypertension. Pulm Circ. 2016 Dec; 6(4):498-507. PMID: 28090291.
    View in: PubMed
  7. Olsson KM, Channick R. Pregnancy in pulmonary arterial hypertension. Eur Respir Rev. 2016 Dec; 25(142):431-437. PMID: 27903665.
    View in: PubMed
  8. Berra L, Rodriguez-Lopez J, Rezoagli E, Yu B, Fisher DF, Semigran MJ, Bloch DB, Channick RN, Zapol WM. Electric Plasma-generated Nitric Oxide: Hemodynamic Effects in Patients with Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 Nov 01; 194(9):1168-1170. PMID: 27797618.
    View in: PubMed
  9. Mehta S, Sastry BK, Souza R, Torbicki A, Ghofrani HA, Channick RN, Delcroix M, Pulido T, Simonneau G, Wlodarczyk J, Rubin LJ, Jansa P, Hunsche E, Galiè N, Perchenet L, Sitbon O. Macitentan Improves Health-Related Quality of Life for Patients With Pulmonary Arterial Hypertension: Results From the Randomized Controlled SERAPHIN Trial. Chest. 2017 Jan; 151(1):106-118. PMID: 27671974.
    View in: PubMed
  10. Tamura Y, Channick RN. New paradigm for pulmonary arterial hypertension treatment. Curr Opin Pulm Med. 2016 Sep; 22(5):429-33. PMID: 27434819.
    View in: PubMed
  11. Humbert M, Channick RN. Pulmonary hypertension. Curr Opin Pulm Med. 2016 Sep; 22(5):399. PMID: 27428648.
    View in: PubMed
  12. Pepke-Zaba J, Jais X, Channick R. Medical Therapy in Chronic Thromboembolic Pulmonary Hypertension. Ann Am Thorac Soc. 2016 Jul; 13 Suppl 3:S248-54. PMID: 27571006.
    View in: PubMed
  13. Tapson VF, Platt DM, Xia F, Teal SA, de la Orden M, Divers CH, Satler CA, Joish VN, Channick RN. Monitoring for Pulmonary Hypertension Following Pulmonary Embolism: The INFORM Study. Am J Med. 2016 Sep; 129(9):978-985.e2. PMID: 27046247.
    View in: PubMed
  14. Kabrhel C, Rosovsky R, Channick R, Jaff MR, Weinberg I, Sundt T, Dudzinski DM, Rodriguez-Lopez J, Parry BA, Harshbarger S, Chang Y, Rosenfield K. A Multidisciplinary Pulmonary Embolism Response Team: Initial 30-Month Experience With a Novel Approach to Delivery of Care to Patients With Submassive and Massive Pulmonary Embolism. Chest. 2016 Aug; 150(2):384-93. PMID: 27006156.
    View in: PubMed
  15. Sitbon O, Channick R, Chin KM, Frey A, Gaine S, Galiè N, Ghofrani HA, Hoeper MM, Lang IM, Preiss R, Rubin LJ, Di Scala L, Tapson V, Adzerikho I, Liu J, Moiseeva O, Zeng X, Simonneau G, McLaughlin VV. Selexipag for the Treatment of Pulmonary Arterial Hypertension. N Engl J Med. 2015 Dec 24; 373(26):2522-33. PMID: 26699168.
    View in: PubMed
  16. Parikh VN, Park J, Nikolic I, Channick R, Yu PB, De Marco T, Hsue PY, Chan SY. Brief Report: Coordinated Modulation of Circulating miR-21 in HIV, HIV-Associated Pulmonary Arterial Hypertension, and HIV/Hepatitis C Virus Coinfection. J Acquir Immune Defic Syndr. 2015 Nov 01; 70(3):236-41. PMID: 26473639; PMCID: PMC4610144 [Available on 11/01/16].
  17. Simonneau G, Channick RN, Delcroix M, Galiè N, Ghofrani HA, Jansa P, Le Brun FO, Mehta S, Perchenet L, Pulido T, Sastry BK, Sitbon O, Souza R, Torbicki A, Rubin LJ. Incident and prevalent cohorts with pulmonary arterial hypertension: insight from SERAPHIN. Eur Respir J. 2015 Dec; 46(6):1711-20. PMID: 26493786; PMCID: PMC4664609.
  18. Wilcox SR, Kabrhel C, Channick RN. Pulmonary Hypertension and Right Ventricular Failure in Emergency Medicine. Ann Emerg Med. 2015 Dec; 66(6):619-28. PMID: 26342901.
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  19. LeVarge BL, Channick RN. The changing paradigm in pulmonary hypertension trials: longer duration, new endpoints. Curr Opin Pulm Med. 2015 Sep; 21(5):438-45. PMID: 26176969.
    View in: PubMed
  20. DuBrock HM, Kradin RL, Rodriguez-Lopez JM, Channick RN. Pulmonary capillary hemangiomatosis: the role of invasive cardiopulmonary exercise testing. Pulm Circ. 2015 Sep; 5(3):580-6. PMID: 26401260; PMCID: PMC4556510.
  21. Selej M, Romero AJ, Channick RN, Clozel M. Development of macitentan for the treatment of pulmonary arterial hypertension. Ann N Y Acad Sci. 2015 Nov; 1358:68-81. PMID: 26291180.
    View in: PubMed
  22. Witkin AS, Channick RN. Chronic Thromboembolic Pulmonary Hypertension: the End Result of Pulmonary Embolism. Curr Cardiol Rep. 2015 Aug; 17(8):63. PMID: 26099554.
    View in: PubMed
  23. McLaughlin V, Channick RN, Ghofrani HA, Lemarié JC, Naeije R, Packer M, Souza R, Tapson VF, Tolson J, Al Hiti H, Meyer G, Hoeper MM. Bosentan added to sildenafil therapy in patients with pulmonary arterial hypertension. Eur Respir J. 2015 Aug; 46(2):405-13. PMID: 26113687.
    View in: PubMed
  24. Sheu EG, Channick R, Gee DW. Improvement in severe pulmonary hypertension in obese patients after laparoscopic gastric bypass or sleeve gastrectomy. Surg Endosc. 2016 Feb; 30(2):633-7. PMID: 26091991.
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  25. Afilalo J, Grapsa J, Nihoyannopoulos P, Beaudoin J, Gibbs JS, Channick RN, Langleben D, Rudski LG, Hua L, Handschumacher MD, Picard MH, Levine RA. Leaflet area as a determinant of tricuspid regurgitation severity in patients with pulmonary hypertension. Circ Cardiovasc Imaging. 2015 May; 8(5). PMID: 25977303; PMCID: PMC4435735.
  26. DuBrock HM, Channick RN, Krowka MJ. What's new in the treatment of portopulmonary hypertension? Expert Rev Gastroenterol Hepatol. 2015 Jul; 9(7):983-92. PMID: 25882070.
    View in: PubMed
  27. Channick RN, Delcroix M, Ghofrani HA, Hunsche E, Jansa P, Le Brun FO, Mehta S, Pulido T, Rubin LJ, Sastry BK, Simonneau G, Sitbon O, Souza R, Torbicki A, Galiè N. Effect of macitentan on hospitalizations: results from the SERAPHIN trial. JACC Heart Fail. 2015 Jan; 3(1):1-8. PMID: 25457902.
    View in: PubMed
  28. Kim NH, Delcroix M, Jenkins DP, Channick R, Dartevelle P, Jansa P, Lang I, Madani MM, Ogino H, Pengo V, Mayer E. [Chronic thromboembolic pulmonary hypertension]. Turk Kardiyol Dern Ars. 2014 Oct; 42 Suppl 1:119-29. PMID: 25697039.
    View in: PubMed
  29. LeVarge BL, Channick RN. Chronic thromboembolic pulmonary hypertension: evolution in management. Curr Opin Pulm Med. 2014 Sep; 20(5):400-8. PMID: 25093673.
    View in: PubMed
  30. DuBrock HM, Channick RN. Macitentan for the treatment of pulmonary arterial hypertension. Expert Rev Respir Med. 2014 Aug; 8(4):393-9. PMID: 24998329.
    View in: PubMed
  31. LeVarge BL, Pomerantsev E, Channick RN. Reliance on end-expiratory wedge pressure leads to misclassification of pulmonary hypertension. Eur Respir J. 2014 Aug; 44(2):425-34. PMID: 24925918; PMCID: PMC4259251.
  32. Saukkonen K, Tan TC, Sharma A, Channick RN, Murali MR, Zukerberg LR. Case records of the Massachusetts General Hospital. Case 9-2014. A 34-year-old woman with increasing dyspnea. N Engl J Med. 2014 Mar 20; 370(12):1149-57. PMID: 24645948.
    View in: PubMed
  33. Provias T, Dudzinski DM, Jaff MR, Rosenfield K, Channick R, Baker J, Weinberg I, Donaldson C, Narayan R, Rassi AN, Kabrhel C. The Massachusetts General Hospital Pulmonary Embolism Response Team (MGH PERT): creation of a multidisciplinary program to improve care of patients with massive and submassive pulmonary embolism. Hosp Pract (1995). 2014 Feb; 42(1):31-7. PMID: 24566594.
    View in: PubMed
  34. Kim NH, Delcroix M, Jenkins DP, Channick R, Dartevelle P, Jansa P, Lang I, Madani MM, Ogino H, Pengo V, Mayer E. Chronic thromboembolic pulmonary hypertension. J Am Coll Cardiol. 2013 Dec 24; 62(25 Suppl):D92-9. PMID: 24355646.
    View in: PubMed
  35. Khanna D, Gladue H, Channick R, Chung L, Distler O, Furst DE, Hachulla E, Humbert M, Langleben D, Mathai SC, Saggar R, Visovatti S, Altorok N, Townsend W, FitzGerald J, McLaughlin VV. Recommendations for screening and detection of connective tissue disease-associated pulmonary arterial hypertension. Arthritis Rheum. 2013 Dec; 65(12):3194-201. PMID: 24022584; PMCID: PMC3883571.
  36. Channick R, Preston I, Klinger JR. Oral therapies for pulmonary arterial hypertension: endothelin receptor antagonists and phosphodiesterase-5 inhibitors. Clin Chest Med. 2013 Dec; 34(4):811-24. PMID: 24267306.
    View in: PubMed
  37. Kabrhel C, Jaff MR, Channick RN, Baker JN, Rosenfield K. A multidisciplinary pulmonary embolism response team. Chest. 2013 Nov; 144(5):1738-1739. PMID: 24189880.
    View in: PubMed
  38. Pulido T, Adzerikho I, Channick RN, Delcroix M, Galiè N, Ghofrani HA, Jansa P, Jing ZC, Le Brun FO, Mehta S, Mittelholzer CM, Perchenet L, Sastry BK, Sitbon O, Souza R, Torbicki A, Zeng X, Rubin LJ, Simonneau G. Macitentan and morbidity and mortality in pulmonary arterial hypertension. N Engl J Med. 2013 Aug 29; 369(9):809-18. PMID: 23984728.
    View in: PubMed
  39. Sise ME, Courtwright AM, Channick RN. Pulmonary hypertension in patients with chronic and end-stage kidney disease. Kidney Int. 2013 Oct; 84(4):682-92. PMID: 23739239.
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  40. Channick RN. Combination therapy in pulmonary arterial hypertension. Am J Cardiol. 2013 Apr 16; 111(8 Suppl):16C-20C. PMID: 23558025.
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  41. Channick RN, Frantz RP, Kawut SM, Palevsky H, Tumuluri R, Sulica R, Lauto PO, Benton WW, de Boisblanc B. A multicenter, retrospective study of patients with pulmonary arterial hypertension transitioned from parenteral prostacyclin therapy to inhaled iloprost. Pulm Circ. 2013 Apr; 3(2):381-8. PMID: 24015339; PMCID: PMC3757833.
  42. Malhotra R, Paskin-Flerlage S, Zamanian RT, Zimmerman P, Schmidt JW, Deng DY, Southwood M, Spencer R, Lai CS, Parker W, Channick RN, Morrell NW, Elliott CG, Yu PB. Circulating angiogenic modulatory factors predict survival and functional class in pulmonary arterial hypertension. Pulm Circ. 2013 Apr; 3(2):369-80. PMID: 24015338; PMCID: PMC3757832.
  43. Bourge RC, Tapson VF, Safdar Z, Benza RL, Channick RN, Rosenzweig EB, Shapiro S, White RJ, McSwain CS, Gotzkowsky SK, Nelsen AC, Rubin LJ. Rapid transition from inhaled iloprost to inhaled treprostinil in patients with pulmonary arterial hypertension. Cardiovasc Ther. 2013 Feb; 31(1):38-44. PMID: 22970909; PMCID: PMC3561685.
  44. McLaughlin VV, Langer A, Tan M, Clements PJ, Oudiz RJ, Tapson VF, Channick RN, Rubin LJ. Contemporary trends in the diagnosis and management of pulmonary arterial hypertension: an initiative to close the care gap. Chest. 2013 Feb 01; 143(2):324-332. PMID: 22910999.
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  45. Kovach AE, Cheng GZ, Channick CL, Channick RN, Muniappan A, Gaissert HA, Kradin RL. Postradiofrequency ablation inflammatory pseudotumor associated with pulmonary venoocclusive disease: case report and review of the literature. Ann Diagn Pathol. 2013 Oct; 17(5):466-9. PMID: 23352326.
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  46. LeVarge BL, Channick RN. Inhaled treprostinil for the treatment of pulmonary arterial hypertension. Expert Rev Respir Med. 2012 Jun; 6(3):255-65. PMID: 22788940.
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  47. Channick RN, Lorenzo ME, Wu CC, Hoang MP. Case records of the Massachusetts General Hospital. Case 11-2012. A 60-year-old man with weakness, rash, and renal failure. N Engl J Med. 2012 Apr 12; 366(15):1434-43. PMID: 22494124.
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  48. Barst RJ, Channick R, Ivy D, Goldstein B. Clinical perspectives with long-term pulsed inhaled nitric oxide for the treatment of pulmonary arterial hypertension. Pulm Circ. 2012 Apr-Jun; 2(2):139-47. PMID: 22837854; PMCID: PMC3401867.
  49. Channick RN, Voswinckel R, Rubin LJ. Inhaled treprostinil: a therapeutic review. Drug Des Devel Ther. 2012; 6:19-28. PMID: 22291467; PMCID: PMC3267519.
  50. Benza RL, Seeger W, McLaughlin VV, Channick RN, Voswinckel R, Tapson VF, Robbins IM, Olschewski H, Rubin LJ. Long-term effects of inhaled treprostinil in patients with pulmonary arterial hypertension: the Treprostinil Sodium Inhalation Used in the Management of Pulmonary Arterial Hypertension (TRIUMPH) study open-label extension. J Heart Lung Transplant. 2011 Dec; 30(12):1327-33. PMID: 22055098.
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  51. Clements PJ, Tan M, McLaughlin VV, Oudiz RJ, Tapson VF, Channick RN, Rubin LJ, Langer A. The pulmonary arterial hypertension quality enhancement research initiative: comparison of patients with idiopathic PAH to patients with systemic sclerosis-associated PAH. Ann Rheum Dis. 2012 Feb; 71(2):249-52. PMID: 21998119.
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  52. Kerr KM, Auger WR, Marsh JJ, Devendra G, Spragg RG, Kim NH, Channick RN, Jamieson SW, Madani MM, Manecke GR, Roth DM, Shragg GP, Fedullo PF. Efficacy of methylprednisolone in preventing lung injury following pulmonary thromboendarterectomy. Chest. 2012 Jan; 141(1):27-35. PMID: 21835900; PMCID: PMC3251267.
  53. McLaughlin VV, Benza RL, Rubin LJ, Channick RN, Voswinckel R, Tapson VF, Robbins IM, Olschewski H, Rubenfire M, Seeger W. Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial. J Am Coll Cardiol. 2010 May 04; 55(18):1915-22. PMID: 20430262.
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  54. Hoeper MM, Barberà JA, Channick RN, Hassoun PM, Lang IM, Manes A, Martinez FJ, Naeije R, Olschewski H, Pepke-Zaba J, Redfield MM, Robbins IM, Souza R, Torbicki A, McGoon M. Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension. J Am Coll Cardiol. 2009 Jun 30; 54(1 Suppl):S85-96. PMID: 19555862.
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  55. Simonneau G, Robbins IM, Beghetti M, Channick RN, Delcroix M, Denton CP, Elliott CG, Gaine SP, Gladwin MT, Jing ZC, Krowka MJ, Langleben D, Nakanishi N, Souza R. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2009 Jun 30; 54(1 Suppl):S43-54. PMID: 19555858.
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  56. Yu Y, Keller SH, Remillard CV, Safrina O, Nicholson A, Zhang SL, Jiang W, Vangala N, Landsberg JW, Wang JY, Thistlethwaite PA, Channick RN, Robbins IM, Loyd JE, Ghofrani HA, Grimminger F, Schermuly RT, Cahalan MD, Rubin LJ, Yuan JX. A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation. 2009 May 05; 119(17):2313-22. PMID: 19380626; PMCID: PMC2749566.
  57. Rothman A, Galindo A, Channick R, Blanchard D. Amplatzer device closure of a tortuous Gerbode (left ventricle-to-right atrium) defect complicated by transient hemolysis in an octogenarian. J Invasive Cardiol. 2008 Sep; 20(9):E273-6. PMID: 18762687.
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  58. Chin KM, Channick RN, de Lemos JA, Kim NH, Torres F, Rubin LJ. Hemodynamics and epoprostenol use are associated with thrombocytopenia in pulmonary arterial hypertension. Chest. 2009 Jan; 135(1):130-136. PMID: 18719056.
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  59. Hennigan S, Channick RN, Silverman GJ. Rituximab treatment of pulmonary arterial hypertension associated with systemic lupus erythematosus: a case report. Lupus. 2008 Aug; 17(8):754-6. PMID: 18625655.
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  60. Desai SA, Channick RN. Exercise in patients with pulmonary arterial hypertension. J Cardiopulm Rehabil Prev. 2008 Jan-Feb; 28(1):12-6. PMID: 18277824.
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  61. Chin KM, Channick RN, Kim NH, Rubin LJ. Central venous blood oxygen saturation monitoring in patients with chronic pulmonary arterial hypertension treated with continuous IV epoprostenol: correlation with measurements of hemodynamics and plasma brain natriuretic peptide levels. Chest. 2007 Sep; 132(3):786-92. PMID: 17646224.
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  62. McLaughlin VV, Channick R. Sickle cell disease-associated pulmonary hypertension: a coat of many colors. Am J Respir Crit Care Med. 2007 Jun 15; 175(12):1218-9. PMID: 17545455.
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  63. Remillard CV, Tigno DD, Platoshyn O, Burg ED, Brevnova EE, Conger D, Nicholson A, Rana BK, Channick RN, Rubin LJ, O'connor DT, Yuan JX. Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension. Am J Physiol Cell Physiol. 2007 May; 292(5):C1837-53. PMID: 17267549.
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  64. Chin KM, Channick RN, Rubin LJ. Is methamphetamine use associated with idiopathic pulmonary arterial hypertension? Chest. 2006 Dec; 130(6):1657-63. PMID: 17166979.
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  65. Channick RN, Olschewski H, Seeger W, Staub T, Voswinckel R, Rubin LJ. Safety and efficacy of inhaled treprostinil as add-on therapy to bosentan in pulmonary arterial hypertension. J Am Coll Cardiol. 2006 Oct 03; 48(7):1433-7. PMID: 17010807.
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  66. Walker AM, Langleben D, Korelitz JJ, Rich S, Rubin LJ, Strom BL, Gonin R, Keast S, Badesch D, Barst RJ, Bourge RC, Channick R, Frost A, Gaine S, McGoon M, McLaughlin V, Murali S, Oudiz RJ, Robbins IM, Tapson V, Abenhaim L, Constantine G. Temporal trends and drug exposures in pulmonary hypertension: an American experience. Am Heart J. 2006 Sep; 152(3):521-6. PMID: 16923424.
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  67. McLaughlin VV, Oudiz RJ, Frost A, Tapson VF, Murali S, Channick RN, Badesch DB, Barst RJ, Hsu HH, Rubin LJ. Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2006 Dec 01; 174(11):1257-63. PMID: 16946127.
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  68. Bartolome SD, Channick RN. Sildenafil for pulmonary arterial hypertension. Future Cardiol. 2006 Mar; 2(2):137-43. PMID: 19804069.
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  69. Lee SH, Channick RN. Endothelin antagonism in pulmonary arterial hypertension. Semin Respir Crit Care Med. 2005 Aug; 26(4):402-8. PMID: 16121317.
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  70. Humbert M, Barst RJ, Robbins IM, Channick RN, Galiè N, Boonstra A, Rubin LJ, Horn EM, Manes A, Simonneau G. Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2. Eur Respir J. 2004 Sep; 24(3):353-9. PMID: 15358690.
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  71. Channick R, Williamson TL. Diagnosis and treatment of pulmonary arterial hypertension. Cardiol Clin. 2004 Aug; 22(3):441-52, vii. PMID: 15302363.
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  72. Doyle RL, McCrory D, Channick RN, Simonneau G, Conte J. Surgical treatments/interventions for pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest. 2004 Jul; 126(1 Suppl):63S-71S. PMID: 15249495.
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  73. Ghofrani HA, Pepke-Zaba J, Barbera JA, Channick R, Keogh AM, Gomez-Sanchez MA, Kneussl M, Grimminger F. Nitric oxide pathway and phosphodiesterase inhibitors in pulmonary arterial hypertension. J Am Coll Cardiol. 2004 Jun 16; 43(12 Suppl S):68S-72S. PMID: 15194181.
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  74. Channick RN, Sitbon O, Barst RJ, Manes A, Rubin LJ. Endothelin receptor antagonists in pulmonary arterial hypertension. J Am Coll Cardiol. 2004 Jun 16; 43(12 Suppl S):62S-67S. PMID: 15194180.
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  75. Bresser P, Fedullo PF, Auger WR, Channick RN, Robbins IM, Kerr KM, Jamieson SW, Rubin LJ. Continuous intravenous epoprostenol for chronic thromboembolic pulmonary hypertension. Eur Respir J. 2004 Apr; 23(4):595-600. PMID: 15083760.
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  76. Chin K, Channick R. Bosentan. Expert Rev Cardiovasc Ther. 2004 Mar; 2(2):175-82. PMID: 15151466.
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  77. Yung GL, Fedullo PF, Kinninger K, Johnson W, Channick RN. Comparison of impedance cardiography to direct Fick and thermodilution cardiac output determination in pulmonary arterial hypertension. Congest Heart Fail. 2004 Mar-Apr; 10(2 Suppl 2):7-10. PMID: 15073478.
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  78. Kim NH, Fesler P, Channick RN, Knowlton KU, Ben-Yehuda O, Lee SH, Naeije R, Rubin LJ. Preoperative partitioning of pulmonary vascular resistance correlates with early outcome after thromboendarterectomy for chronic thromboembolic pulmonary hypertension. Circulation. 2004 Jan 06; 109(1):18-22. PMID: 14699009.
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  79. Jamieson SW, Kapelanski DP, Sakakibara N, Manecke GR, Thistlethwaite PA, Kerr KM, Channick RN, Fedullo PF, Auger WR. Pulmonary endarterectomy: experience and lessons learned in 1,500 cases. Ann Thorac Surg. 2003 Nov; 76(5):1457-62; discussion 1462-4. PMID: 14602267.
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  80. Kim NH, Channick RN, Rubin LJ. Successful withdrawal of long-term epoprostenol therapy for pulmonary arterial hypertension. Chest. 2003 Oct; 124(4):1612-5. PMID: 14555600.
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  81. Tulevski II, Bresser P, Hirsch A, Groenink M, Channick RN, Jamieson SW, Mulder BJ. Decreased plasma neurohormones and improved cardiac performance after surgical treatment of chronic pulmonary embolism. Ann Thorac Surg. 2003 Jul; 76(1):287-90. PMID: 12842565.
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  82. Sitbon O, Badesch DB, Channick RN, Frost A, Robbins IM, Simonneau G, Tapson VF, Rubin LJ. Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension: a 1-year follow-up study. Chest. 2003 Jul; 124(1):247-54. PMID: 12853530.
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  83. Barst RJ, McGoon M, McLaughlin V, Tapson V, Rich S, Rubin L, Wasserman K, Oudiz R, Shapiro S, Robbins IM, Channick R, Badesch D, Rayburn BK, Flinchbaugh R, Sigman J, Arneson C, Jeffs R. Beraprost therapy for pulmonary arterial hypertension. J Am Coll Cardiol. 2003 Jun 18; 41(12):2119-25. PMID: 12821234.
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  84. Galiè N, Hinderliter AL, Torbicki A, Fourme T, Simonneau G, Pulido T, Espinola-Zavaleta N, Rocchi G, Manes A, Frantz R, Kurzyna M, Nagueh SF, Barst R, Channick R, Dujardin K, Kronenberg A, Leconte I, Rainisio M, Rubin L. Effects of the oral endothelin-receptor antagonist bosentan on echocardiographic and doppler measures in patients with pulmonary arterial hypertension. J Am Coll Cardiol. 2003 Apr 16; 41(8):1380-6. PMID: 12706935.
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  85. Fesler P, Pagnamenta A, Vachiéry JL, Brimioulle S, Abdel Kafi S, Boonstra A, Delcroix M, Channick RN, Rubin LJ, Naeije R. Single arterial occlusion to locate resistance in patients with pulmonary hypertension. Eur Respir J. 2003 Jan; 21(1):31-6. PMID: 12570105.
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  86. Yung GL, Kriett JM, Jamieson SW, Johnson FW, Newhart J, Kinninger K, Channick RN. Outpatient inhaled nitric oxide in a patient with idiopathic pulmonary fibrosis: a bridge to lung transplantation. J Heart Lung Transplant. 2001 Nov; 20(11):1224-7. PMID: 11704484.
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  87. Channick RN, Simonneau G, Sitbon O, Robbins IM, Frost A, Tapson VF, Badesch DB, Roux S, Rainisio M, Bodin F, Rubin LJ. Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study. Lancet. 2001 Oct 06; 358(9288):1119-23. PMID: 11597664.
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  88. Robbins IM, Barst RJ, Channick RN, Rubin LJ. Pulmonary vasoreactivity in PPH. J Am Coll Cardiol. 2001 Oct; 38(4):1267-8. PMID: 11587028.
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  89. Channick RN, Rubin LJ. New and experimental therapies for pulmonary hypertension. Clin Chest Med. 2001 Sep; 22(3):539-45. PMID: 11590847.
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  90. Fedullo PF, Auger WR, Channick RN, Kerr KM, Rubin LJ. Chronic thromboembolic pulmonary hypertension. Clin Chest Med. 2001 Sep; 22(3):561-81. PMID: 11590849.
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  91. Bailey CL, Channick RN, Rubin LJ. A new era in the treatment of primary pulmonary hypertension. Heart. 2001 Mar; 85(3):251-2. PMID: 11179256; PMCID: PMC1729642.
  92. Channick R, Badesch DB, Tapson VF, Simonneau G, Robbins I, Frost A, Roux S, Rainisio M, Bodin F, Rubin LJ. Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary hypertension: a placebo-controlled study. J Heart Lung Transplant. 2001 Feb; 20(2):262-263. PMID: 11250530.
    View in: PubMed
  93. Bailey CL, Channick RN, Auger WR, Fedullo PF, Kerr KM, Yung GL, Rubin LJ. "High probability" perfusion lung scans in pulmonary venoocclusive disease. Am J Respir Crit Care Med. 2000 Nov; 162(5):1974-8. PMID: 11069842.
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  94. Kerr KM, Auger WR, Marsh JJ, Comito RM, Fedullo RL, Smits GJ, Kapelanski DP, Fedullo PF, Channick RN, Jamieson SW, Moser KM. The use of cylexin (CY-1503) in prevention of reperfusion lung injury in patients undergoing pulmonary thromboendarterectomy. Am J Respir Crit Care Med. 2000 Jul; 162(1):14-20. PMID: 10903213.
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  95. Kim H, Yung GL, Marsh JJ, Konopka RG, Pedersen CA, Chiles PG, Morris TA, Channick RN. Pulmonary vascular remodeling distal to pulmonary artery ligation is accompanied by upregulation of endothelin receptors and nitric oxide synthase. Exp Lung Res. 2000 Jun; 26(4):287-301. PMID: 10923246.
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  96. Kim H, Yung GL, Marsh JJ, Konopka RG, Pedersen CA, Chiles PG, Morris TA, Channick RN. Endothelin mediates pulmonary vascular remodelling in a canine model of chronic embolic pulmonary hypertension. Eur Respir J. 2000 Apr; 15(4):640-8. PMID: 10780753.
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  97. Channick RN, Rubin LJ. Combination therapy for pulmonary hypertension: a glimpse into the future? Crit Care Med. 2000 Mar; 28(3):896-7. PMID: 10752856.
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  98. Fedullo PF, Rubin LJ, Kerr KM, Auger WR, Channick RN. The natural history of acute and chronic thromboembolic disease: the search for the missing link. Eur Respir J. 2000 Mar; 15(3):435-7. PMID: 10759432.
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  99. Bergin CJ, Hauschildt JP, Brown MA, Channick RN, Fedullo PF. Identifying the cause of unilateral hypoperfusion in patients suspected to have chronic pulmonary thromboembolism: diagnostic accuracy of helical CT and conventional angiography. Radiology. 1999 Dec; 213(3):743-9. PMID: 10580948.
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  100. Mo M, Kapelanski DP, Mitruka SN, Auger WR, Fedullo PF, Channick RN, Kerr K, Archibald C, Jamieson SW. Reoperative pulmonary thromboendarterectomy. Ann Thorac Surg. 1999 Nov; 68(5):1770-6; discussion 1776-7. PMID: 10585057.
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  101. Rothman A, Sklansky MS, Lucas VW, Kashani IA, Shaughnessy RD, Channick RN, Auger WR, Fedullo PF, Smith CM, Kriett JM, Jamieson SW. Atrial septostomy as a bridge to lung transplantation in patients with severe pulmonary hypertension. Am J Cardiol. 1999 Sep 15; 84(6):682-6. PMID: 10498139.
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  102. Archibald CJ, Auger WR, Fedullo PF, Channick RN, Kerr KM, Jamieson SW, Kapelanski DP, Watt CN, Moser KM. Long-term outcome after pulmonary thromboendarterectomy. Am J Respir Crit Care Med. 1999 Aug; 160(2):523-8. PMID: 10430723.
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  103. Auger WR, Channick RN, Kerr KM, Fedullo PF. Evaluation of patients with suspected chronic thromboembolic pulmonary hypertension. Semin Thorac Cardiovasc Surg. 1999 Apr; 11(2):179-90. PMID: 10378862.
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  104. Yung GL, Channick RN, Fedullo PF, Auger WR, Kerr KM, Jamieson SW, Kapelanski DP, Moser KM. Successful pulmonary thromboendarterectomy in two patients with sickle cell disease. Am J Respir Crit Care Med. 1998 May; 157(5 Pt 1):1690-3. PMID: 9603156.
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  105. Bergin CJ, Hauschildt J, Rios G, Belezzuoli EV, Huynh T, Channick RN. Accuracy of MR angiography compared with radionuclide scanning in identifying the cause of pulmonary arterial hypertension. AJR Am J Roentgenol. 1997 Jun; 168(6):1549-55. PMID: 9168722.
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  106. Wilson WC, Kapelanski DP, Benumof JL, Newhart 2nd JW, Johnson FW, Channick RN. Inhaled nitric oxide (40 ppm) during one-lung ventilation, in the lateral decubitus position, does not decrease pulmonary vascular resistance or improve oxygenation in normal patients. J Cardiothorac Vasc Anesth. 1997 Apr; 11(2):172-6. PMID: 9105988.
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  107. Bradley SP, Auger WR, Moser KM, Fedullo PF, Channick RN, Bloor CM. Right ventricular pathology in chronic pulmonary hypertension. Am J Cardiol. 1996 Sep 01; 78(5):584-7. PMID: 8806351.
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  108. Morris TA, Auger WR, Ysrael MZ, Olson LK, Channick RN, Fedullo PF, Moser KM. Parenchymal scarring is associated with restrictive spirometric defects in patients with chronic thromboembolic pulmonary hypertension. Chest. 1996 Aug; 110(2):399-403. PMID: 8697841.
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  109. Hirsch AM, Moser KM, Auger WR, Channick RN, Fedullo PF. Unilateral pulmonary artery thrombotic occlusion: is distal arteriopathy a consequence? Am J Respir Crit Care Med. 1996 Aug; 154(2 Pt 1):491-6. PMID: 8756827.
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  110. Channick RN, Newhart JW, Johnson FW, Williams PJ, Auger WR, Fedullo PF, Moser KM. Pulsed delivery of inhaled nitric oxide to patients with primary pulmonary hypertension: an ambulatory delivery system and initial clinical tests. Chest. 1996 Jun; 109(6):1545-9. PMID: 8769509.
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  111. Fedullo PF, Auger WR, Channick RN, Moser KM, Jamieson SW. Chronic thromboembolic pulmonary hypertension. Clin Chest Med. 1995 Jun; 16(2):353-74. PMID: 7656546.
    View in: PubMed
  112. Channick RN, Newhart JW, Johnson FW, Moser KM. Inhaled nitric oxide reverses hypoxic pulmonary vasoconstriction in dogs. A practical nitric oxide delivery and monitoring system. Chest. 1994 Jun; 105(6):1842-7. PMID: 8205886.
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  113. Channick RN, Hoch RC, Newhart JW, Johnson FW, Smith CM. Improvement in pulmonary hypertension and hypoxemia during nitric oxide inhalation in a patient with end-stage pulmonary fibrosis. Am J Respir Crit Care Med. 1994 Mar; 149(3 Pt 1):811-4. PMID: 8118653.
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  114. Jamieson SW, Auger WR, Fedullo PF, Channick RN, Kriett JM, Tarazi RY, Moser KM. Experience and results with 150 pulmonary thromboendarterectomy operations over a 29-month period. J Thorac Cardiovasc Surg. 1993 Jul; 106(1):116-26; discussion 126-7. PMID: 8320990.
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