Harvard Catalyst Profiles

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Gary Jay Brenner, M.D.,Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21NS088013 (BRENNER, GARY JAY) Jul 1, 2015 - Jun 30, 2017
    NIH/NINDS
    Translation of AAV P0 ICE schwannoma gene therapy to clinical Trials
    Role: Principal Investigator
  2. R01NS081146 (BRENNER, GARY JAY) Sep 30, 2012 - Jul 31, 2017
    NIH/NINDS
    Mechanisms of Caspase-1 Mediated Schwannoma Regression
    Role: Principal Investigator
  3. K08NS044139 (BRENNER, GARY JAY) Aug 1, 2002 - Jul 31, 2008
    NIH/NINDS
    NMDA Receptor Phosphorylation and Trafficking after Pain
    Role: Principal Investigator
  4. F30MH010144 (BRENNER, GARY JAY) Jan 22, 1992
    NIH/NIMH
    DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ahmed SG, Abdelanabi A, Doha M, Brenner GJ. Correction to: Schwannoma gene therapy by adeno-associated virus delivery of the pore-forming protein Gasdermin-D. Cancer Gene Ther. 2020 Apr; 27(3-4):265. PMID: 31056550.
    Citations:    
  2. Taylor NE, Long H, Pei J, Kukutla P, Phero A, Hadaegh F, Abdelnabi A, Solt K, Brenner GJ. The rostromedial tegmental nucleus: a key modulator of pain and opioid analgesia. Pain. 2019 11; 160(11):2524-2534. PMID: 31246732.
    Citations:    
  3. Sagers JE, Sahin MI, Moon I, Ahmed SG, Stemmer-Rachamimov A, Brenner GJ, Stankovic KM. NLRP3 inflammasome activation in human vestibular schwannoma: Implications for tumor-induced hearing loss. Hear Res. 2019 09 15; 381:107770. PMID: 31430634.
    Citations:    
  4. Ahmed SG, Abdelnabi A, Maguire CA, Doha M, Sagers JE, Lewis RM, Muzikansky A, Giovannini M, Stemmer-Rachamimov A, Stankovic KM, Fulci G, Brenner GJ. Gene therapy with apoptosis-associated speck-like protein, a newly described schwannoma tumor suppressor, inhibits schwannoma growth in vivo. Neuro Oncol. 2019 07 11; 21(7):854-866. PMID: 30977509.
    Citations:    
  5. Ahmed SG, Hadaegh F, Brenner GJ. Developing myelin specific promoters for schwannoma gene therapy. J Neurosci Methods. 2019 07 15; 323:77-81. PMID: 31125589.
    Citations:    
  6. Ahmed SG, Abdelanabi A, Doha M, Brenner GJ. Schwannoma gene therapy by adeno-associated virus delivery of the pore-forming protein Gasdermin-D. Cancer Gene Ther. 2019 09; 26(9-10):259-267. PMID: 30622323.
    Citations:    Fields:    
  7. Przkora R, Antony A, McNeil A, Brenner GJ, Mesrobian J, Rosenquist R, Abouleish AE. Do Pain Medicine Fellowship Programs Provide Education in Practice Management? A Survey of Pain Medicine Fellowship Programs. Pain Physician. 2018 01; 21(1):E43-E48. PMID: 29357339.
    Citations:    Fields:    Translation:Humans
  8. Bateman BT, Brenner GJ. An important step forward in the safe use of epidural steroid injections. Anesthesiology. 2015 May; 122(5):964-6. PMID: 25668413.
    Citations:    Fields:    Translation:HumansAnimals
  9. Giblin K, Newmark JL, Brenner GJ, Wainger BJ. Headache plus: trigeminal and autonomic features in a case of cervicogenic headache responsive to third occipital nerve radiofrequency ablation. Pain Med. 2014 Mar; 15(3):473-8. PMID: 24401103.
    Citations: 1     Fields:    Translation:Humans
  10. Prabhakar S, Taherian M, Gianni D, Conlon TJ, Fulci G, Brockmann J, Stemmer-Rachamimov A, Sena-Esteves M, Breakefield XO, Brenner GJ. Regression of schwannomas induced by adeno-associated virus-mediated delivery of caspase-1. Hum Gene Ther. 2013 Feb; 24(2):152-62. PMID: 23140466.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  11. Brenner GJ, Newmark JL, Nemark JL, Raemer D. Curriculum and cases for pain medicine crisis resource management education. Anesth Analg. 2013 Jan; 116(1):107-10. PMID: 23223099.
    Citations: 2     Fields:    Translation:Humans
  12. Mizrak A, Bolukbasi MF, Ozdener GB, Brenner GJ, Madlener S, Erkan EP, Ströbel T, Breakefield XO, Saydam O. Genetically engineered microvesicles carrying suicide mRNA/protein inhibit schwannoma tumor growth. Mol Ther. 2013 Jan; 21(1):101-8. PMID: 22910294.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  13. Brenner GJ, Kueppenbender K, Mao J, Spike J. Ethical challenges and interventional pain medicine. Curr Pain Headache Rep. 2012 Feb; 16(1):1-8. PMID: 22160519.
    Citations:    Fields:    Translation:Humans
  14. Ma CH, Brenner GJ, Omura T, Samad OA, Costigan M, Inquimbert P, Niederkofler V, Salie R, Sun CC, Lin HY, Arber S, Coppola G, Woolf CJ, Samad TA. The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling. J Neurosci. 2011 Dec 14; 31(50):18391-400. PMID: 22171041.
    Citations: 15     Fields:    Translation:AnimalsCells
  15. Ma CH, Omura T, Cobos EJ, Latrémolière A, Ghasemlou N, Brenner GJ, van Veen E, Barrett L, Sawada T, Gao F, Coppola G, Gertler F, Costigan M, Geschwind D, Woolf CJ. Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice. J Clin Invest. 2011 Nov; 121(11):4332-47. PMID: 21965333.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  16. Saydam O, Senol O, Würdinger T, Mizrak A, Ozdener GB, Stemmer-Rachamimov AO, Yi M, Stephens RM, Krichevsky AM, Saydam N, Brenner GJ, Breakefield XO. miRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways. Cancer Res. 2011 Feb 01; 71(3):852-61. PMID: 21156648.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  17. Saydam O, Ozdener GB, Senol O, Mizrak A, Prabhakar S, Stemmer-Rachamimov AO, Breakefield XO, Brenner GJ. A novel imaging-compatible sciatic nerve schwannoma model. J Neurosci Methods. 2011 Jan 30; 195(1):75-7. PMID: 21111000.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  18. del Camino D, Murphy S, Heiry M, Barrett LB, Earley TJ, Cook CA, Petrus MJ, Zhao M, D'Amours M, Deering N, Brenner GJ, Costigan M, Hayward NJ, Chong JA, Fanger CM, Woolf CJ, Patapoutian A, Moran MM. TRPA1 contributes to cold hypersensitivity. J Neurosci. 2010 Nov 10; 30(45):15165-74. PMID: 21068322.
    Citations: 91     Fields:    Translation:AnimalsCells
  19. Xia Y, Babitt JL, Bouley R, Zhang Y, Da Silva N, Chen S, Zhuang Z, Samad TA, Brenner GJ, Anderson JL, Hong CC, Schneyer AL, Brown D, Lin HY. Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells. J Am Soc Nephrol. 2010 Apr; 21(4):666-77. PMID: 20167703.
    Citations: 15     Fields:    Translation:AnimalsCells
  20. Costigan M, Moss A, Latremoliere A, Johnston C, Verma-Gandhu M, Herbert TA, Barrett L, Brenner GJ, Vardeh D, Woolf CJ, Fitzgerald M. T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity. J Neurosci. 2009 Nov 18; 29(46):14415-22. PMID: 19923276.
    Citations: 100     Fields:    Translation:AnimalsCells
  21. Prabhakar S, Brenner GJ, Sung B, Messerli SM, Mao J, Sena-Esteves M, Stemmer-Rachamimov A, Tannous B, Breakefield XO. Imaging and therapy of experimental schwannomas using HSV amplicon vector-encoding apoptotic protein under Schwann cell promoter. Cancer Gene Ther. 2010 Apr; 17(4):266-74. PMID: 19834516.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  22. Binshtok AM, Wang H, Zimmermann K, Amaya F, Vardeh D, Shi L, Brenner GJ, Ji RR, Bean BP, Woolf CJ, Samad TA. Nociceptors are interleukin-1beta sensors. J Neurosci. 2008 Dec 24; 28(52):14062-73. PMID: 19109489.
    Citations: 143     Fields:    Translation:AnimalsCells
  23. Kohno T, Wang H, Amaya F, Brenner GJ, Cheng JK, Ji RR, Woolf CJ. Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity. J Neurosci. 2008 Apr 23; 28(17):4533-40. PMID: 18434532.
    Citations: 33     Fields:    Translation:AnimalsCells
  24. Griffin RS, Costigan M, Brenner GJ, Ma CH, Scholz J, Moss A, Allchorne AJ, Stahl GL, Woolf CJ. Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity. J Neurosci. 2007 Aug 08; 27(32):8699-708. PMID: 17687047.
    Citations: 76     Fields:    Translation:AnimalsCells
  25. Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, Kuner R. Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci. 2007 Jul; 10(7):870-9. PMID: 17558404.
    Citations: 163     Fields:    Translation:AnimalsCells
  26. Wang H, Ehnert C, Brenner GJ, Woolf CJ. Bradykinin and peripheral sensitization. Biol Chem. 2006 Jan; 387(1):11-4. PMID: 16497159.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  27. Wang H, Kohno T, Amaya F, Brenner GJ, Ito N, Allchorne A, Ji RR, Woolf CJ. Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. J Neurosci. 2005 Aug 31; 25(35):7986-92. PMID: 16135755.
    Citations: 25     Fields:    Translation:AnimalsCells
  28. Xia Y, Sidis Y, Mukherjee A, Samad TA, Brenner G, Woolf CJ, Lin HY, Schneyer A. Localization and action of Dragon (repulsive guidance molecule b), a novel bone morphogenetic protein coreceptor, throughout the reproductive axis. Endocrinology. 2005 Aug; 146(8):3614-21. PMID: 15890774.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  29. Kawasaki Y, Kohno T, Zhuang ZY, Brenner GJ, Wang H, Van Der Meer C, Befort K, Woolf CJ, Ji RR. Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. J Neurosci. 2004 Sep 22; 24(38):8310-21. PMID: 15385614.
    Citations: 111     Fields:    Translation:AnimalsCells
  30. Brenner GJ, Ji RR, Shaffer S, Woolf CJ. Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons. Eur J Neurosci. 2004 Jul; 20(2):375-84. PMID: 15233747.
    Citations: 39     Fields:    Translation:AnimalsCells
  31. Ji RR, Befort K, Brenner GJ, Woolf CJ. ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. J Neurosci. 2002 Jan 15; 22(2):478-85. PMID: 11784793.
    Citations: 124     Fields:    Translation:AnimalsCells
  32. Ji RR, Baba H, Brenner GJ, Woolf CJ. Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci. 1999 Dec; 2(12):1114-9. PMID: 10570489.
    Citations: 198     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.