Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Gary Jay Brenner, M.D.,Ph.D.

Profile Picture

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R41NS120338 (LUO, SUSAN X) Sep 30, 2020 - Jul 31, 2022
    Salmonella typhimurium-based Bacteriotherapy for Orphan Benign Tumors: Neurofibromatosis Type II (NF2)
    Role: Co-Principal Investigator
  2. R21NS088013 (BRENNER, GARY JAY) Jul 1, 2015 - Jun 30, 2018
    Translation of AAV P0 ICE schwannoma gene therapy to clinical Trials
    Role: Principal Investigator
  3. R01NS081146 (BRENNER, GARY JAY) Sep 30, 2012 - Jul 31, 2018
    Mechanisms of Caspase-1 Mediated Schwannoma Regression
    Role: Principal Investigator
  4. K08NS044139 (BRENNER, GARY JAY) Aug 1, 2002 - Jul 31, 2008
    NMDA Receptor Phosphorylation and Trafficking after Pain
    Role: Principal Investigator
  5. F30MH010144 (BRENNER, GARY JAY) Jan 22, 1992
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ezaka M, Marutani E, Miyazaki Y, Kanemaru E, Selig MK, Boerboom SL, Ostrom KF, Stemmer-Rachamimov A, Bloch DB, Brenner GJ, Ohshima E, Ichinose F. Oral Administration of Glutathione Trisulfide Increases Reactive Sulfur Levels in Dorsal Root Ganglion and Ameliorates Paclitaxel-Induced Peripheral Neuropathy in Mice. Antioxidants (Basel). 2022 Oct 27; 11(11). PMID: 36358494; PMCID: PMC9686764.
  2. Ahmed SG, Oliva G, Shao M, Wang X, Mekalanos JJ, Brenner GJ. Intratumoral injection of schwannoma with attenuated Salmonella typhimurium induces antitumor immunity and controls tumor growth. Proc Natl Acad Sci U S A. 2022 06 14; 119(24):e2202719119. PMID: 35675425; PMCID: PMC9214496.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Ahmed SG, Maguire CA, Cao SA, Brenner GJ. Schwannoma Gene Therapy via Adeno-Associated Viral Vector Delivery of Apoptosis-Associated Speck-like Protein Containing CARD (ASC): Preclinical Efficacy and Safety. Int J Mol Sci. 2022 Jan 13; 23(2). PMID: 35055004; PMCID: PMC8775599.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Purvis T, Newmark J, Brenner GJ, Brodnik D, Kohan L. Pain Education Innovations During a Global Pandemic. Pain Med. 2021 09 08; 22(9):1891-1896. PMID: 34411245.
    Citations:    Fields:    Translation:HumansPHPublic Health
  5. Kukutla P, Ahmed SG, DuBreuil DM, Abdelnabi A, Cetinbas M, Fulci G, Aldikacti B, Stemmer-Rachamimov A, Plotkin SR, Wainger B, Sadreyev RI, Brenner GJ. Transcriptomic signature of painful human neurofibromatosis type 2 schwannomas. Ann Clin Transl Neurol. 2021 07; 8(7):1508-1514. PMID: 34053190; PMCID: PMC8283170.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Vlasov K, Pei J, Nehs CJ, Guidera JA, Zhang ER, Kenny JD, Houle TT, Brenner GJ, Taylor NE, Solt K. Activation of GABAergic Neurons in the Rostromedial Tegmental Nucleus and Other Brainstem Regions Promotes Sedation and Facilitates Sevoflurane Anesthesia in Mice. Anesth Analg. 2021 04 01; 132(4):e50-e55. PMID: 33560660; PMCID: PMC7969415.
    Citations: 1     Fields:    Translation:AnimalsCells
  7. Kohan L, Durbhakula S, Zaidi M, Phillips CR, Rowan CC, Brenner GJ, Cohen SP. Changes in Pain Medicine Training Programs Associated With COVID-19: Survey Results. Anesth Analg. 2021 Mar 01; 132(3):605-615. PMID: 33177326.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  8. Ahmed SG, Abdelanabi A, Doha M, Brenner GJ. Correction to: Schwannoma gene therapy by adeno-associated virus delivery of the pore-forming protein Gasdermin-D. Cancer Gene Ther. 2020 04; 27(3-4):265. PMID: 31056550.
    Citations: 1     Fields:    
  9. Taylor NE, Long H, Pei J, Kukutla P, Phero A, Hadaegh F, Abdelnabi A, Solt K, Brenner GJ. The rostromedial tegmental nucleus: a key modulator of pain and opioid analgesia. Pain. 2019 11; 160(11):2524-2534. PMID: 31246732; PMCID: PMC7343630.
    Citations: 7     Fields:    Translation:AnimalsCells
  10. Sagers JE, Sahin MI, Moon I, Ahmed SG, Stemmer-Rachamimov A, Brenner GJ, Stankovic KM. NLRP3 inflammasome activation in human vestibular schwannoma: Implications for tumor-induced hearing loss. Hear Res. 2019 09 15; 381:107770. PMID: 31430634.
    Citations: 9     Fields:    Translation:Humans
  11. Ahmed SG, Abdelnabi A, Maguire CA, Doha M, Sagers JE, Lewis RM, Muzikansky A, Giovannini M, Stemmer-Rachamimov A, Stankovic KM, Fulci G, Brenner GJ. Gene therapy with apoptosis-associated speck-like protein, a newly described schwannoma tumor suppressor, inhibits schwannoma growth in vivo. Neuro Oncol. 2019 07 11; 21(7):854-866. PMID: 30977509.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  12. Ahmed SG, Hadaegh F, Brenner GJ. Developing myelin specific promoters for schwannoma gene therapy. J Neurosci Methods. 2019 07 15; 323:77-81. PMID: 31125589; PMCID: PMC6557449.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Ahmed SG, Abdelanabi A, Doha M, Brenner GJ. Schwannoma gene therapy by adeno-associated virus delivery of the pore-forming protein Gasdermin-D. Cancer Gene Ther. 2019 09; 26(9-10):259-267. PMID: 30622323.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  14. Przkora R, Antony A, McNeil A, Brenner GJ, Mesrobian J, Rosenquist R, Abouleish AE. Do Pain Medicine Fellowship Programs Provide Education in Practice Management? A Survey of Pain Medicine Fellowship Programs. Pain Physician. 2018 01; 21(1):E43-E48. PMID: 29357339.
    Citations: 2     Fields:    Translation:Humans
  15. Bateman BT, Brenner GJ. An important step forward in the safe use of epidural steroid injections. Anesthesiology. 2015 May; 122(5):964-6. PMID: 25668413; PMCID: PMC4439298.
    Citations:    Fields:    Translation:HumansAnimals
  16. Giblin K, Newmark JL, Brenner GJ, Wainger BJ. Headache plus: trigeminal and autonomic features in a case of cervicogenic headache responsive to third occipital nerve radiofrequency ablation. Pain Med. 2014 Mar; 15(3):473-8. PMID: 24401103.
    Citations: 3     Fields:    Translation:Humans
  17. Prabhakar S, Taherian M, Gianni D, Conlon TJ, Fulci G, Brockmann J, Stemmer-Rachamimov A, Sena-Esteves M, Breakefield XO, Brenner GJ. Regression of schwannomas induced by adeno-associated virus-mediated delivery of caspase-1. Hum Gene Ther. 2013 Feb; 24(2):152-62. PMID: 23140466.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  18. Brenner GJ, Newmark JL, Nemark JL, Raemer D. Curriculum and cases for pain medicine crisis resource management education. Anesth Analg. 2013 Jan; 116(1):107-10. PMID: 23223099.
    Citations: 4     Fields:    Translation:Humans
  19. Mizrak A, Bolukbasi MF, Ozdener GB, Brenner GJ, Madlener S, Erkan EP, Ströbel T, Breakefield XO, Saydam O. Genetically engineered microvesicles carrying suicide mRNA/protein inhibit schwannoma tumor growth. Mol Ther. 2013 Jan; 21(1):101-8. PMID: 22910294.
    Citations: 124     Fields:    Translation:HumansAnimalsCells
  20. Brenner GJ, Kueppenbender K, Mao J, Spike J. Ethical challenges and interventional pain medicine. Curr Pain Headache Rep. 2012 Feb; 16(1):1-8. PMID: 22160519.
    Citations:    Fields:    Translation:Humans
  21. Ma CH, Brenner GJ, Omura T, Samad OA, Costigan M, Inquimbert P, Niederkofler V, Salie R, Sun CC, Lin HY, Arber S, Coppola G, Woolf CJ, Samad TA. The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling. J Neurosci. 2011 Dec 14; 31(50):18391-400. PMID: 22171041.
    Citations: 30     Fields:    Translation:AnimalsCells
  22. Ma CH, Omura T, Cobos EJ, Latrémolière A, Ghasemlou N, Brenner GJ, van Veen E, Barrett L, Sawada T, Gao F, Coppola G, Gertler F, Costigan M, Geschwind D, Woolf CJ. Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice. J Clin Invest. 2011 Nov; 121(11):4332-47. PMID: 21965333; PMCID: PMC3223863.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
  23. Saydam O, Senol O, Würdinger T, Mizrak A, Ozdener GB, Stemmer-Rachamimov AO, Yi M, Stephens RM, Krichevsky AM, Saydam N, Brenner GJ, Breakefield XO. miRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways. Cancer Res. 2011 Feb 01; 71(3):852-61. PMID: 21156648.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  24. Saydam O, Ozdener GB, Senol O, Mizrak A, Prabhakar S, Stemmer-Rachamimov AO, Breakefield XO, Brenner GJ. A novel imaging-compatible sciatic nerve schwannoma model. J Neurosci Methods. 2011 Jan 30; 195(1):75-7. PMID: 21111000.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  25. del Camino D, Murphy S, Heiry M, Barrett LB, Earley TJ, Cook CA, Petrus MJ, Zhao M, D'Amours M, Deering N, Brenner GJ, Costigan M, Hayward NJ, Chong JA, Fanger CM, Woolf CJ, Patapoutian A, Moran MM. TRPA1 contributes to cold hypersensitivity. J Neurosci. 2010 Nov 10; 30(45):15165-74. PMID: 21068322.
    Citations: 125     Fields:    Translation:AnimalsCells
  26. Xia Y, Babitt JL, Bouley R, Zhang Y, Da Silva N, Chen S, Zhuang Z, Samad TA, Brenner GJ, Anderson JL, Hong CC, Schneyer AL, Brown D, Lin HY. Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells. J Am Soc Nephrol. 2010 Apr; 21(4):666-77. PMID: 20167703.
    Citations: 20     Fields:    Translation:AnimalsCells
  27. Costigan M, Moss A, Latremoliere A, Johnston C, Verma-Gandhu M, Herbert TA, Barrett L, Brenner GJ, Vardeh D, Woolf CJ, Fitzgerald M. T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity. J Neurosci. 2009 Nov 18; 29(46):14415-22. PMID: 19923276; PMCID: PMC2813708.
    Citations: 163     Fields:    Translation:AnimalsCells
  28. Prabhakar S, Brenner GJ, Sung B, Messerli SM, Mao J, Sena-Esteves M, Stemmer-Rachamimov A, Tannous B, Breakefield XO. Imaging and therapy of experimental schwannomas using HSV amplicon vector-encoding apoptotic protein under Schwann cell promoter. Cancer Gene Ther. 2010 Apr; 17(4):266-74. PMID: 19834516.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  29. Binshtok AM, Wang H, Zimmermann K, Amaya F, Vardeh D, Shi L, Brenner GJ, Ji RR, Bean BP, Woolf CJ, Samad TA. Nociceptors are interleukin-1beta sensors. J Neurosci. 2008 Dec 24; 28(52):14062-73. PMID: 19109489.
    Citations: 258     Fields:    Translation:AnimalsCells
  30. Kohno T, Wang H, Amaya F, Brenner GJ, Cheng JK, Ji RR, Woolf CJ. Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity. J Neurosci. 2008 Apr 23; 28(17):4533-40. PMID: 18434532.
    Citations: 46     Fields:    Translation:AnimalsCells
  31. Griffin RS, Costigan M, Brenner GJ, Ma CH, Scholz J, Moss A, Allchorne AJ, Stahl GL, Woolf CJ. Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity. J Neurosci. 2007 Aug 08; 27(32):8699-708. PMID: 17687047; PMCID: PMC6672952.
    Citations: 102     Fields:    Translation:AnimalsCells
  32. Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, Kuner R. Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci. 2007 Jul; 10(7):870-9. PMID: 17558404; PMCID: PMC2234438.
    Citations: 226     Fields:    Translation:AnimalsCells
  33. Wang H, Ehnert C, Brenner GJ, Woolf CJ. Bradykinin and peripheral sensitization. Biol Chem. 2006 Jan; 387(1):11-4. PMID: 16497159.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  34. Wang H, Kohno T, Amaya F, Brenner GJ, Ito N, Allchorne A, Ji RR, Woolf CJ. Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. J Neurosci. 2005 Aug 31; 25(35):7986-92. PMID: 16135755; PMCID: PMC6725443.
    Citations: 43     Fields:    Translation:AnimalsCells
  35. Xia Y, Sidis Y, Mukherjee A, Samad TA, Brenner G, Woolf CJ, Lin HY, Schneyer A. Localization and action of Dragon (repulsive guidance molecule b), a novel bone morphogenetic protein coreceptor, throughout the reproductive axis. Endocrinology. 2005 Aug; 146(8):3614-21. PMID: 15890774; PMCID: PMC1351303.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  36. Kawasaki Y, Kohno T, Zhuang ZY, Brenner GJ, Wang H, Van Der Meer C, Befort K, Woolf CJ, Ji RR. Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. J Neurosci. 2004 Sep 22; 24(38):8310-21. PMID: 15385614; PMCID: PMC6729681.
    Citations: 137     Fields:    Translation:AnimalsCells
  37. Brenner GJ, Ji RR, Shaffer S, Woolf CJ. Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons. Eur J Neurosci. 2004 Jul; 20(2):375-84. PMID: 15233747.
    Citations: 45     Fields:    Translation:AnimalsCells
  38. Ji RR, Befort K, Brenner GJ, Woolf CJ. ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. J Neurosci. 2002 Jan 15; 22(2):478-85. PMID: 11784793; PMCID: PMC6758654.
    Citations: 173     Fields:    Translation:AnimalsCells
  39. Ji RR, Baba H, Brenner GJ, Woolf CJ. Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci. 1999 Dec; 2(12):1114-9. PMID: 10570489.
    Citations: 275     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Brenner's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (264)
Co-Authors (31)
Similar People (60)
Same Department 
Physical Neighbors
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.