Harvard Catalyst Profiles

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Richard Leslie Stevens, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI054950 (STEVENS, RICHARD L) Feb 15, 2005 - Jan 31, 2011
    RasGRP4-dependent Responses in Mast Cells
    Role: Principal Investigator
  2. R01AI059746 (STEVENS, RICHARD L) Apr 1, 2004 - May 31, 2014
    Synovial mast cells in inflammatory arthritis
    Role: Principal Investigator
  3. R13AI049543 (STEVENS, RICHARD L) Jul 1, 2001 - Jun 30, 2002
    4th International Workshop on the Mast Cell &Basophil
    Role: Principal Investigator
  4. R01HL063284 (STEVENS, RICHARD L) Sep 1, 1999 - Aug 31, 2003
    Role: Principal Investigator
  5. P30AR042689 (KUPPER, THOMAS S.) Apr 1, 1994 - Oct 13, 2011
    Harvard Skin Disease Research Center
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Stevens RL, McNeil HP, Wensing LA, Shin K, Wong GW, Hansbro PM, Krilis SA. Experimental Arthritis Is Dependent on Mouse Mast Cell Protease-5. J Biol Chem. 2017 03 31; 292(13):5392-5404. PMID: 28193842.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  2. Sheppard JP, Stevens R, Gill P, Martin U, Godwin M, Hanley J, Heneghan C, Hobbs FD, Mant J, McKinstry B, Myers M, Nunan D, Ward A, Williams B, McManus RJ. Predicting Out-of-Office Blood Pressure in the Clinic (PROOF-BP): Derivation and Validation of a Tool to Improve the Accuracy of Blood Pressure Measurement in Clinical Practice. Hypertension. 2016 May; 67(5):941-50. PMID: 27001299.
    Citations: 18     Fields:    Translation:Humans
  3. Zhou S, Tanaka K, O'Keeffe M, Qi M, El-Assaad F, Weaver JC, Chen G, Weatherall C, Wang Y, Giannakopoulos B, Chen L, Yu D, Hamilton MJ, Wensing LA, Stevens RL, Krilis SA. CD117+ Dendritic and Mast Cells Are Dependent on RasGRP4 to Function as Accessory Cells for Optimal Natural Killer Cell-Mediated Responses to Lipopolysaccharide. PLoS One. 2016; 11(3):e0151638. PMID: 26982501; PMCID: PMC4794117.
    Citations: 2     Fields:    Translation:AnimalsCells
  4. Kono M, Yasuda S, Stevens RL, Koide H, Kurita T, Shimizu Y, Kanetsuka Y, Oku K, Bohgaki T, Amengual O, Horita T, Shimizu T, Majima T, Koike T, Atsumi T. Ras guanine nucleotide-releasing protein 4 is aberrantly expressed in the fibroblast-like synoviocytes of patients with rheumatoid arthritis and controls their proliferation. Arthritis Rheumatol. 2015 Feb; 67(2):396-407. PMID: 25330932.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  5. Hamilton MJ, Frei SM, Stevens RL. The multifaceted mast cell in inflammatory bowel disease. Inflamm Bowel Dis. 2014 Dec; 20(12):2364-78. PMID: 25401721; PMCID: PMC4428674.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  6. Wong GW, Zhuo L, Kimata K, Lam BK, Satoh N, Stevens RL. Ancient origin of mast cells. Biochem Biophys Res Commun. 2014 Aug 22; 451(2):314-8. PMID: 25094046.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  7. Hansbro PM, Hamilton MJ, Fricker M, Gellatly SL, Jarnicki AG, Zheng D, Frei SM, Wong GW, Hamadi S, Zhou S, Foster PS, Krilis SA, Stevens RL. Importance of mast cell Prss31/transmembrane tryptase/tryptase-? in lung function and experimental chronic obstructive pulmonary disease and colitis. J Biol Chem. 2014 Jun 27; 289(26):18214-27. PMID: 24821729.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  8. Prieto-García A, Castells MC, Hansbro PM, Stevens RL. Mast cell-restricted tetramer-forming tryptases and their beneficial roles in hemostasis and blood coagulation. Immunol Allergy Clin North Am. 2014 May; 34(2):263-81. PMID: 24745673.
    Citations: 2     Fields:    Translation:HumansCells
  9. Bankova LG, Lezcano C, Pejler G, Stevens RL, Murphy GF, Austen KF, Gurish MF. Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions. J Immunol. 2014 Mar 15; 192(6):2812-20. PMID: 24523504; PMCID: PMC3970423.
    Citations: 17     Fields:    Translation:AnimalsCells
  10. Farmer AJ, Stevens R, Hirst J, Lung T, Oke J, Clarke P, Glasziou P, Neil A, Dunger D, M Colhoun H, Pugh C, Wong G, Perera R, Shine B. Optimal strategies for identifying kidney disease in diabetes: properties of screening tests, progression of renal dysfunction and impact of treatment - systematic review and modelling of progression and cost-effectiveness. Health Technol Assess. 2014 Feb; 18(14):1-128. PMID: 24576414; PMCID: PMC4781444.
    Citations: 12     Fields:    Translation:Humans
  11. Douaiher J, Succar J, Lancerotto L, Gurish MF, Orgill DP, Hamilton MJ, Krilis SA, Stevens RL. Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing. Adv Immunol. 2014; 122:211-52. PMID: 24507159.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  12. Prieto-García A, Castells MC, Stevens RL. Mast cell-derived htryptase-beta functions as a potent anticoagulant by proteolytically damaging fibrinogen. J Investig Allergol Clin Immunol. 2014; 24(4):286-7. PMID: 25219118.
    Citations:    Fields:    Translation:Humans
  13. Flynn-Evans EE, Mucci L, Stevens RG, Lockley SW. Shiftwork and prostate-specific antigen in the National Health and Nutrition Examination Survey. J Natl Cancer Inst. 2013 Sep 04; 105(17):1292-7. PMID: 23943864.
    Citations: 35     Fields:    Translation:HumansPHPublic Health
  14. Kang JH, Kueck AS, Stevens R, Curhan G, De Vivo I, Rosner B, Alexander E, Tworoger SS. A large cohort study of hypothyroidism and hyperthyroidism in relation to gynecologic cancers. Obstet Gynecol Int. 2013; 2013:743721. PMID: 23956749.
    Citations: 10     
  15. Magarinos NJ, Bryant KJ, Fosang AJ, Adachi R, Stevens RL, McNeil HP. Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogens. J Immunol. 2013 Aug 01; 191(3):1404-12. PMID: 23797671; PMCID: PMC3727140.
    Citations: 14     Fields:    Translation:AnimalsCells
  16. Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, Deane A, Keely S, Horvat JC, Yang M, Oliver BG, van Rooijen N, Inman MD, Adachi R, Soberman RJ, Hamadi S, Wark PA, Foster PS, Hansbro PM. A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis. J Allergy Clin Immunol. 2013 Mar; 131(3):752-62. PMID: 23380220; PMCID: PMC4060894.
    Citations: 89     Fields:    Translation:AnimalsCells
  17. Kaieda S, Wang JX, Shnayder R, Fishgal N, Hei H, Lee RT, Stevens RL, Nigrovic PA. Interleukin-33 primes mast cells for activation by IgG immune complexes. PLoS One. 2012; 7(10):e47252. PMID: 23071771.
    Citations: 7     Fields:    Translation:AnimalsCells
  18. Hansbro PM, Starkey MR, Kim RY, Stevens RL, Foster PS, Horvat JC. Programming of the lung by early-life infection. J Dev Orig Health Dis. 2012 Jun; 3(3):153-8. PMID: 25102006.
    Citations: 1     Fields:    
  19. Adachi R, Krilis SA, Nigrovic PA, Hamilton MJ, Chung K, Thakurdas SM, Boyce JA, Anderson P, Stevens RL. Ras guanine nucleotide-releasing protein-4 (RasGRP4) involvement in experimental arthritis and colitis. J Biol Chem. 2012 Jun 08; 287(24):20047-55. PMID: 22511759.
    Citations: 13     Fields:    Translation:AnimalsCells
  20. Simarro M, Giannattasio G, Xing W, Lundequist EM, Stewart S, Stevens RL, Orduña A, Boyce JA, Anderson PJ. The translational repressor T-cell intracellular antigen-1 (TIA-1) is a key modulator of Th2 and Th17 responses driving pulmonary inflammation induced by exposure to house dust mite. Immunol Lett. 2012 Aug 30; 146(1-2):8-14. PMID: 22525013.
    Citations: 5     Fields:    Translation:AnimalsCells
  21. Prieto-García A, Zheng D, Adachi R, Xing W, Lane WS, Chung K, Anderson P, Hansbro PM, Castells M, Stevens RL. Mast cell restricted mouse and human tryptase·heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogen. J Biol Chem. 2012 Mar 09; 287(11):7834-44. PMID: 22235124.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  22. Zhang J, Sun J, Lindholt JS, Sukhova GK, Sinnamon M, Stevens RL, Adachi R, Libby P, Thompson RW, Shi GP. Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation. Circ Res. 2011 May 27; 108(11):1316-27. PMID: 21493897.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  23. Hamilton MJ, Sinnamon MJ, Lyng GD, Glickman JN, Wang X, Xing W, Krilis SA, Blumberg RS, Adachi R, Lee DM, Stevens RL. Essential role for mast cell tryptase in acute experimental colitis. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):290-5. PMID: 21173247.
    Citations: 53     Fields:    Translation:AnimalsCells
  24. Younan G, Suber F, Xing W, Shi T, Kunori Y, Abrink M, Pejler G, Schlenner SM, Rodewald HR, Moore FD, Stevens RL, Adachi R, Austen KF, Gurish MF. The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5. J Immunol. 2010 Dec 15; 185(12):7681-90. PMID: 21076070; PMCID: PMC3058366.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  25. Kaieda S, Shin K, Nigrovic PA, Seki K, Lee RT, Stevens RL, Lee DM. Synovial fibroblasts promote the expression and granule accumulation of tryptase via interleukin-33 and its receptor ST-2 (IL1RL1). J Biol Chem. 2010 Jul 09; 285(28):21478-86. PMID: 20427273.
    Citations: 25     Fields:    Translation:AnimalsCells
  26. Hamilton MJ, Stevens RL. Stress in the ER leads to inflammatory bowel disease. Inflamm Bowel Dis. 2009 Nov; 15(11):1765-6. PMID: 19408317.
    Citations: 1     Fields:    
  27. Sun J, Zhang J, Lindholt JS, Sukhova GK, Liu J, He A, Abrink M, Pejler G, Stevens RL, Thompson RW, Ennis TL, Gurish MF, Libby P, Shi GP. Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation. Circulation. 2009 Sep 15; 120(11):973-82. PMID: 19720934; PMCID: PMC2757146.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  28. Flynn-Evans EE, Stevens RG, Tabandeh H, Schernhammer ES, Lockley SW. Total visual blindness is protective against breast cancer. Cancer Causes Control. 2009 Nov; 20(9):1753-6. PMID: 19649715.
    Citations: 30     Fields:    Translation:Humans
  29. Flynn-Evans EE, Stevens RG, Tabandeh H, Schernhammer ES, Lockley SW. Effect of light perception on menarche in blind women. Ophthalmic Epidemiol. 2009 Jul-Aug; 16(4):243-8. PMID: 19874146.
    Citations: 2     Fields:    Translation:Humans
  30. Shin K, Nigrovic PA, Crish J, Boilard E, McNeil HP, Larabee KS, Adachi R, Gurish MF, Gobezie R, Stevens RL, Lee DM. Mast cells contribute to autoimmune inflammatory arthritis via their tryptase/heparin complexes. J Immunol. 2009 Jan 01; 182(1):647-56. PMID: 19109198; PMCID: PMC2610352.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  31. Meador JA, Baldwin AJ, Catala P, Jeffrey WH, Joux F, Moss JA, Dean Pakulski J, Stevens R, Mitchell DL. Sunlight-induced DNA damage in marine micro-organisms collected along a latitudinal gradient from 70 degrees N to 68 degrees S. Photochem Photobiol. 2009 Jan-Feb; 85(1):412-20. PMID: 19161407.
    Citations: 2     Fields:    
  32. McNeil HP, Shin K, Campbell IK, Wicks IP, Adachi R, Lee DM, Stevens RL. The mouse mast cell-restricted tetramer-forming tryptases mouse mast cell protease 6 and mouse mast cell protease 7 are critical mediators in inflammatory arthritis. Arthritis Rheum. 2008 Aug; 58(8):2338-46. PMID: 18668540.
    Citations: 43     Fields:    Translation:AnimalsCells
  33. Katsoulotos GP, Qi M, Qi JC, Tanaka K, Hughes WE, Molloy TJ, Adachi R, Stevens RL, Krilis SA. The Diacylglycerol-dependent translocation of ras guanine nucleotide-releasing protein 4 inside a human mast cell line results in substantial phenotypic changes, including expression of interleukin 13 receptor alpha2. J Biol Chem. 2008 Jan 18; 283(3):1610-1621. PMID: 18024961.
    Citations: 8     Fields:    Translation:HumansCells
  34. Yasuda S, Stevens RL, Terada T, Takeda M, Hashimoto T, Fukae J, Horita T, Kataoka H, Atsumi T, Koike T. Defective expression of Ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus erythematosus. J Immunol. 2007 Oct 01; 179(7):4890-900. PMID: 17878389.
    Citations: 36     Fields:    Translation:HumansCells
  35. Stevens RL, Adachi R. Protease-proteoglycan complexes of mouse and human mast cells and importance of their beta-tryptase-heparin complexes in inflammation and innate immunity. Immunol Rev. 2007 Jun; 217:155-67. PMID: 17498058.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  36. McNeil HP, Adachi R, Stevens RL. Mast cell-restricted tryptases: structure and function in inflammation and pathogen defense. J Biol Chem. 2007 Jul 20; 282(29):20785-9. PMID: 17504754.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  37. Thakurdas SM, Melicoff E, Sansores-Garcia L, Moreira DC, Petrova Y, Stevens RL, Adachi R. The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections. J Biol Chem. 2007 Jul 20; 282(29):20809-15. PMID: 17456473.
    Citations: 84     Fields:    Translation:AnimalsCells
  38. Habuchi H, Nagai N, Sugaya N, Atsumi F, Stevens RL, Kimata K. Mice deficient in heparan sulfate 6-O-sulfotransferase-1 exhibit defective heparan sulfate biosynthesis, abnormal placentation, and late embryonic lethality. J Biol Chem. 2007 May 25; 282(21):15578-88. PMID: 17405882.
    Citations: 58     Fields:    Translation:AnimalsCells
  39. Wong GW, Stevens RL. Identification of a subgroup of glycosylphosphatidylinositol-anchored tryptases. Biochem Biophys Res Commun. 2005 Oct 21; 336(2):579-84. PMID: 16143303.
    Citations: 3     Fields:    Translation:AnimalsCells
  40. Qi JC, Wang J, Mandadi S, Tanaka K, Roufogalis BD, Madigan MC, Lai K, Yan F, Chong BH, Stevens RL, Krilis SA. Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor. Blood. 2006 Jan 01; 107(1):135-42. PMID: 16144798; PMCID: PMC1895361.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  41. Abonia JP, Friend DS, Austen WG, Moore FD, Carroll MC, Chan R, Afnan J, Humbles A, Gerard C, Knight P, Kanaoka Y, Yasuda S, Morokawa N, Austen KF, Stevens RL, Gurish MF. Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle. J Immunol. 2005 Jun 01; 174(11):7285-91. PMID: 15905575; PMCID: PMC2951006.
    Citations: 37     Fields:    Translation:AnimalsCells
  42. Lemiègre L, Stevens RL, Combret JC, Maddaluno J. Ring fission of chiral cyclic acetals plus intramolecular [4 + 2] cycloaddition: a sequential access to medium-size lactones. Application to the synthesis of carbasugars. Org Biomol Chem. 2005 Apr 07; 3(7):1308-18. PMID: 15785821.
    Citations:    Fields:    Translation:Cells
  43. Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL. Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22. Blood. 2005 May 15; 105(10):3893-901. PMID: 15701722; PMCID: PMC1895090.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  44. Stevens RL, Morokawa N, Wang J, Krilis SA. RasGRP4 in mast cell signalling and disease susceptibility. Novartis Found Symp. 2005; 271:54-68; discussion 68-77, 95-9. PMID: 16605128.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  45. Ahmed M, Sternberg A, Hall G, Thomas A, Smith O, O'Marcaigh A, Wynn R, Stevens R, Addison M, King D, Stewart B, Gibson B, Roberts I, Vyas P. Natural history of GATA1 mutations in Down syndrome. Blood. 2004 Apr 01; 103(7):2480-9. PMID: 14656875.
    Citations: 55     Fields:    Translation:HumansCells
  46. Wong GW, Yasuda S, Morokawa N, Li L, Stevens RL. Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns. J Biol Chem. 2004 Jan 23; 279(4):2438-52. PMID: 14583634.
    Citations: 25     Fields:    Translation:AnimalsCells
  47. Li L, Yang Y, Wong GW, Stevens RL. Mast cells in airway hyporesponsive C3H/HeJ mice express a unique isoform of the signaling protein Ras guanine nucleotide releasing protein 4 that is unresponsive to diacylglycerol and phorbol esters. J Immunol. 2003 Jul 01; 171(1):390-7. PMID: 12817022.
    Citations: 11     Fields:    Translation:AnimalsCells
  48. Wong GW, Yang Y, Yasuda S, Li L, Stevens RL. Mouse mast cells express the tryptic protease neuropsin/Prss19. Biochem Biophys Res Commun. 2003 Mar 28; 303(1):320-5. PMID: 12646205.
    Citations: 3     Fields:    Translation:AnimalsCells
  49. Li L, Yang Y, Stevens RL. RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines. J Biol Chem. 2003 Feb 14; 278(7):4725-9. PMID: 12493770.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  50. Walsh JC, DeKoter RP, Lee HJ, Smith ED, Lancki DW, Gurish MF, Friend DS, Stevens RL, Anastasi J, Singh H. Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates. Immunity. 2002 Nov; 17(5):665-76. PMID: 12433372.
    Citations: 116     Fields:    Translation:AnimalsCells
  51. Li L, Yang Y, Stevens RL. Cloning of rat Ras guanine nucleotide releasing protein 4, and evaluation of its expression in rat mast cells and their bone marrow progenitors. Mol Immunol. 2002 Sep; 38(16-18):1283-8. PMID: 12217396.
    Citations: 5     Fields:    Translation:AnimalsCells
  52. Wong GW, Foster PS, Yasuda S, Qi JC, Mahalingam S, Mellor EA, Katsoulotos G, Li L, Boyce JA, Krilis SA, Stevens RL. Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transducer and activator of transcription (STAT) 6-dependent pathway. J Biol Chem. 2002 Nov 01; 277(44):41906-15. PMID: 12194977.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  53. Qi JC, Stevens RL, Wadley R, Collins A, Cooley M, Naif HM, Nasr N, Cunningham A, Katsoulotos G, Wanigasek Y, Roufogalis B, Krilis SA. IL-16 regulation of human mast cells/basophils and their susceptibility to HIV-1. J Immunol. 2002 Apr 15; 168(8):4127-34. PMID: 11937573.
    Citations: 9     Fields:    Translation:HumansCells
  54. Yang Y, Li L, Wong GW, Krilis SA, Madhusudhan MS, Sali A, Stevens RL. RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function. J Biol Chem. 2002 Jul 12; 277(28):25756-74. PMID: 11956218.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  55. Wong GW, Yasuda S, Madhusudhan MS, Li L, Yang Y, Krilis SA, Sali A, Stevens RL. Human tryptase epsilon (PRSS22), a new member of the chromosome 16p13.3 family of human serine proteases expressed in airway epithelial cells. J Biol Chem. 2001 Dec 28; 276(52):49169-82. PMID: 11602603.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  56. Li Y, Li L, Wadley R, Reddel SW, Qi JC, Archis C, Collins A, Clark E, Cooley M, Kouts S, Naif HM, Alali M, Cunningham A, Wong GW, Stevens RL, Krilis SA. Mast cells/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3, CCR5, and CXCR4. Blood. 2001 Jun 01; 97(11):3484-90. PMID: 11369641.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  57. Huang C, De Sanctis GT, O'Brien PJ, Mizgerd JP, Friend DS, Drazen JM, Brass LF, Stevens RL. Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung. J Biol Chem. 2001 Jul 13; 276(28):26276-84. PMID: 11335723.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  58. Wong GW, Li L, Madhusudhan MS, Krilis SA, Gurish MF, Rothenberg ME, Sali A, Stevens RL. Tryptase 4, a new member of the chromosome 17 family of mouse serine proteases. J Biol Chem. 2001 Jun 08; 276(23):20648-58. PMID: 11259427.
    Citations: 8     Fields:    Translation:AnimalsCells
  59. Friend DS, Gurish MF, Austen KF, Hunt J, Stevens RL. Senescent jejunal mast cells and eosinophils in the mouse preferentially translocate to the spleen and draining lymph node, respectively, during the recovery phase of helminth infection. J Immunol. 2000 Jul 01; 165(1):344-52. PMID: 10861071.
    Citations: 22     Fields:    Translation:AnimalsCells
  60. Huang C, Morales G, Vagi A, Chanasyk K, Ferrazzi M, Burklow C, Qiu WT, Feyfant E, Sali A, Stevens RL. Formation of enzymatically active, homotypic, and heterotypic tetramers of mouse mast cell tryptases. Dependence on a conserved Trp-rich domain on the surface. J Biol Chem. 2000 Jan 07; 275(1):351-8. PMID: 10617625.
    Citations: 10     Fields:    Translation:AnimalsCells
  61. Wong GW, Tang Y, Feyfant E, Sali A, Li L, Li Y, Huang C, Friend DS, Krilis SA, Stevens RL. Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension. J Biol Chem. 1999 Oct 22; 274(43):30784-93. PMID: 10521469.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  62. Humphries DE, Wong GW, Friend DS, Gurish MF, Qiu WT, Huang C, Sharpe AH, Stevens RL. Heparin is essential for the storage of specific granule proteases in mast cells. Nature. 1999 Aug 19; 400(6746):769-72. PMID: 10466726.
    Citations: 111     Fields:    Translation:AnimalsCells
  63. Huang C, Li L, Krilis SA, Chanasyk K, Tang Y, Li Z, Hunt JE, Stevens RL. Human tryptases alpha and beta/II are functionally distinct due, in part, to a single amino acid difference in one of the surface loops that forms the substrate-binding cleft. J Biol Chem. 1999 Jul 09; 274(28):19670-6. PMID: 10391906.
    Citations: 25     Fields:    Translation:HumansCells
  64. Wong GW, Tang Y, Stevens RL. Cloning of the human homolog of mouse transmembrane tryptase. Int Arch Allergy Immunol. 1999 Feb-Apr; 118(2-4):419-21. PMID: 10224463.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  65. Li L, Li Y, Reddel SW, Cherrian M, Friend DS, Stevens RL, Krilis SA. Identification of basophilic cells that express mast cell granule proteases in the peripheral blood of asthma, allergy, and drug-reactive patients. J Immunol. 1998 Nov 01; 161(9):5079-86. PMID: 9794446.
    Citations: 11     Fields:    Translation:HumansCells
  66. Matsumoto R, Matsumoto H, Seki M, Hata M, Asano Y, Kanegasaki S, Stevens RL, Hirashima M. Human ecalectin, a variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes. J Biol Chem. 1998 Jul 03; 273(27):16976-84. PMID: 9642261.
    Citations: 70     Fields:    Translation:HumansCells
  67. Friend DS, Ghildyal N, Gurish MF, Hunt J, Hu X, Austen KF, Stevens RL. Reversible expression of tryptases and chymases in the jejunal mast cells of mice infected with Trichinella spiralis. J Immunol. 1998 Jun 01; 160(11):5537-45. PMID: 9605158.
    Citations: 36     Fields:    Translation:AnimalsCells
  68. Huang C, Sali A, Stevens RL. Regulation and function of mast cell proteases in inflammation. J Clin Immunol. 1998 May; 18(3):169-83. PMID: 9624576.
    Citations: 15     Fields:    Translation:AnimalsCells
  69. Huang C, Friend DS, Qiu WT, Wong GW, Morales G, Hunt J, Stevens RL. Induction of a selective and persistent extravasation of neutrophils into the peritoneal cavity by tryptase mouse mast cell protease 6. J Immunol. 1998 Feb 15; 160(4):1910-9. PMID: 9469453.
    Citations: 47     Fields:    Translation:AnimalsCells
  70. Xia Z, Kam CM, Huang C, Powers JC, Mandle RJ, Stevens RL, Lieberman J. Expression and purification of enzymatically active recombinant granzyme B in a baculovirus system. Biochem Biophys Res Commun. 1998 Feb 13; 243(2):384-9. PMID: 9480818.
    Citations: 9     Fields:    Translation:AnimalsCells
  71. Huang C, Wong GW, Ghildyal N, Gurish MF, Sali A, Matsumoto R, Qiu WT, Stevens RL. The tryptase, mouse mast cell protease 7, exhibits anticoagulant activity in vivo and in vitro due to its ability to degrade fibrinogen in the presence of the diverse array of protease inhibitors in plasma. J Biol Chem. 1997 Dec 12; 272(50):31885-93. PMID: 9395536.
    Citations: 27     Fields:    Translation:AnimalsCells
  72. Hunt JE, Friend DS, Gurish MF, Feyfant E, Sali A, Huang C, Ghildyal N, Stechschulte S, Austen KF, Stevens RL. Mouse mast cell protease 9, a novel member of the chromosome 14 family of serine proteases that is selectively expressed in uterine mast cells. J Biol Chem. 1997 Nov 14; 272(46):29158-66. PMID: 9360993.
    Citations: 13     Fields:    Translation:AnimalsCells
  73. Stevens RL, Jones B, Fishman EK. The CT halo sign: a new finding in intestinal lymphangiectasia. J Comput Assist Tomogr. 1997 Nov-Dec; 21(6):1005-7. PMID: 9386299.
    Citations: 1     Fields:    Translation:Humans
  74. Gurish MF, Friend DS, Webster M, Ghildyal N, Nicodemus CF, Stevens RL. Mouse mast cells that possess segmented/multi-lobular nuclei. Blood. 1997 Jul 01; 90(1):382-90. PMID: 9207474.
    Citations: 4     Fields:    Translation:AnimalsCells
  75. Eklund KK, Humphries DE, Xia Z, Ghildyal N, Friend DS, Gross V, Stevens RL. Glucocorticoids inhibit the cytokine-induced proliferation of mast cells, the high affinity IgE receptor-mediated expression of TNF-alpha, and the IL-10-induced expression of chymases. J Immunol. 1997 May 01; 158(9):4373-80. PMID: 9127001.
    Citations: 14     Fields:    Translation:AnimalsCells
  76. Friend DS, Ghildyal N, Austen KF, Gurish MF, Matsumoto R, Stevens RL. Mast cells that reside at different locations in the jejunum of mice infected with Trichinella spiralis exhibit sequential changes in their granule ultrastructure and chymase phenotype. J Cell Biol. 1996 Oct; 135(1):279-90. PMID: 8858180; PMCID: PMC2121032.
    Citations: 85     Fields:    Translation:AnimalsCells
  77. Ghildyal N, Friend DS, Stevens RL, Austen KF, Huang C, Penrose JF, Sali A, Gurish MF. Fate of two mast cell tryptases in V3 mastocytosis and normal BALB/c mice undergoing passive systemic anaphylaxis: prolonged retention of exocytosed mMCP-6 in connective tissues, and rapid accumulation of enzymatically active mMCP-7 in the blood. J Exp Med. 1996 Sep 01; 184(3):1061-73. PMID: 9064323; PMCID: PMC2192771.
    Citations: 20     Fields:    Translation:AnimalsCells
  78. Xia Z, Ghildyal N, Austen KF, Stevens RL. Post-transcriptional regulation of chymase expression in mast cells. A cytokine-dependent mechanism for controlling the expression of granule neutral proteases of hematopoietic cells. J Biol Chem. 1996 Apr 12; 271(15):8747-53. PMID: 8621509.
    Citations: 15     Fields:    Translation:AnimalsCells
  79. Hunt JE, Stevens RL, Austen KF, Zhang J, Xia Z, Ghildyal N. Natural disruption of the mouse mast cell protease 7 gene in the C57BL/6 mouse. J Biol Chem. 1996 Feb 02; 271(5):2851-5. PMID: 8576265.
    Citations: 31     Fields:    Translation:AnimalsCells
  80. Matsumoto R, Sali A, Ghildyal N, Karplus M, Stevens RL. Packaging of proteases and proteoglycans in the granules of mast cells and other hematopoietic cells. A cluster of histidines on mouse mast cell protease 7 regulates its binding to heparin serglycin proteoglycans. J Biol Chem. 1995 Aug 18; 270(33):19524-31. PMID: 7642636.
    Citations: 22     Fields:    Translation:AnimalsCells
  81. Gurish MF, Pear WS, Stevens RL, Scott ML, Sokol K, Ghildyal N, Webster MJ, Hu X, Austen KF, Baltimore D, et al. Tissue-regulated differentiation and maturation of a v-abl-immortalized mast cell-committed progenitor. Immunity. 1995 Aug; 3(2):175-86. PMID: 7648391.
    Citations: 25     Fields:    Translation:AnimalsCells
  82. Drazen JM, Evans JF, Stevens RL, Shipp MA. Inflammatory effector mechanisms in asthma. Am J Respir Crit Care Med. 1995 Jul; 152(1):403-7. PMID: 7599856.
    Citations:    Fields:    Translation:HumansCells
  83. Gurish MF, Johnson KR, Webster MJ, Stevens RL, Nadeau JH. Location of the mouse mast cell protease 7 gene (Mcpt7) to chromosome 17. Mamm Genome. 1994 Oct; 5(10):656-7. PMID: 7849408.
    Citations: 2     Fields:    Translation:AnimalsCells
  84. Ghildyal N, Friend DS, Freelund R, Austen KF, McNeil HP, Schiller V, Stevens RL. Lack of expression of the tryptase mouse mast cell protease 7 in mast cells of the C57BL/6J mouse. J Immunol. 1994 Sep 15; 153(6):2624-30. PMID: 8077672.
    Citations: 13     Fields:    Translation:AnimalsCells
  85. Eklund KK, Ghildyal N, Austen KF, Friend DS, Schiller V, Stevens RL. Mouse bone marrow-derived mast cells (mBMMC) obtained in vitro from mice that are mast cell-deficient in vivo express the same panel of granule proteases as mBMMC and serosal mast cells from their normal littermates. J Exp Med. 1994 Jul 01; 180(1):67-73. PMID: 8006601; PMCID: PMC2191541.
    Citations: 15     Fields:    Translation:AnimalsCells
  86. Stevens RL, Friend DS, McNeil HP, Schiller V, Ghildyal N, Austen KF. Strain-specific and tissue-specific expression of mouse mast cell secretory granule proteases. Proc Natl Acad Sci U S A. 1994 Jan 04; 91(1):128-32. PMID: 8278352; PMCID: PMC42899.
    Citations: 46     Fields:    Translation:AnimalsCells
  87. Eklund KK, Ghildyal N, Austen KF, Stevens RL. Induction by IL-9 and suppression by IL-3 and IL-4 of the levels of chromosome 14-derived transcripts that encode late-expressed mouse mast cell proteases. J Immunol. 1993 Oct 15; 151(8):4266-73. PMID: 7691943.
    Citations: 41     Fields:    Translation:AnimalsCells
  88. Ghildyal N, Friend DS, Nicodemus CF, Austen KF, Stevens RL. Reversible expression of mouse mast cell protease 2 mRNA and protein in cultured mast cells exposed to IL-10. J Immunol. 1993 Sep 15; 151(6):3206-14. PMID: 8376776.
    Citations: 15     Fields:    Translation:AnimalsCells
  89. Gurish MF, Nadeau JH, Johnson KR, McNeil HP, Grattan KM, Austen KF, Stevens RL. A closely linked complex of mouse mast cell-specific chymase genes on chromosome 14. J Biol Chem. 1993 May 25; 268(15):11372-9. PMID: 8098710.
    Citations: 14     Fields:    Translation:AnimalsCells
  90. Sali A, Matsumoto R, McNeil HP, Karplus M, Stevens RL. Three-dimensional models of four mouse mast cell chymases. Identification of proteoglycan binding regions and protease-specific antigenic epitopes. J Biol Chem. 1993 Apr 25; 268(12):9023-34. PMID: 7682557.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  91. McNeil HP, Reynolds DS, Schiller V, Ghildyal N, Gurley DS, Austen KF, Stevens RL. Isolation, characterization, and transcription of the gene encoding mouse mast cell protease 7. Proc Natl Acad Sci U S A. 1992 Dec 01; 89(23):11174-8. PMID: 1454796; PMCID: PMC50512.
    Citations: 35     Fields:    Translation:AnimalsCells
  92. McNeil HP, Frenkel DP, Austen KF, Friend DS, Stevens RL. Translation and granule localization of mouse mast cell protease-5. Immunodetection with specific antipeptide Ig. J Immunol. 1992 Oct 01; 149(7):2466-72. PMID: 1527387.
    Citations: 14     Fields:    Translation:AnimalsCells
  93. Ghildyal N, McNeil HP, Stechschulte S, Austen KF, Silberstein D, Gurish MF, Somerville LL, Stevens RL. IL-10 induces transcription of the gene for mouse mast cell protease-1, a serine protease preferentially expressed in mucosal mast cells of Trichinella spiralis-infected mice. J Immunol. 1992 Sep 15; 149(6):2123-9. PMID: 1517575.
    Citations: 35     Fields:    Translation:AnimalsCells
  94. Ghildyal N, McNeil HP, Gurish MF, Austen KF, Stevens RL. Transcriptional regulation of the mucosal mast cell-specific protease gene, MMCP-2, by interleukin 10 and interleukin 3. J Biol Chem. 1992 Apr 25; 267(12):8473-7. PMID: 1569097.
    Citations: 29     Fields:    Translation:AnimalsCells
  95. Gurish MF, Ghildyal N, McNeil HP, Austen KF, Gillis S, Stevens RL. Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin 3 and c-kit ligand. J Exp Med. 1992 Apr 01; 175(4):1003-12. PMID: 1372640; PMCID: PMC2119178.
    Citations: 51     Fields:    Translation:AnimalsCells
  96. Stevens RL, Somerville LL, Sewell D, Swafford JR, Caulfield JP, Levi-Schaffer F, Hubbard JR, Dayton ET. Serosal mast cells maintain their viability and promote the metabolism of cartilage proteoglycans when cocultured with chondrocytes. Arthritis Rheum. 1992 Mar; 35(3):325-35. PMID: 1536671.
    Citations: 7     Fields:    Translation:AnimalsCells
  97. Avraham S, Avraham H, Austen KF, Stevens RL. Negative and positive cis-acting elements in the promoter of the mouse gene that encodes the serine/glycine-rich peptide core of secretory granule proteoglycans. J Biol Chem. 1992 Jan 05; 267(1):610-7. PMID: 1730621.
    Citations: 3     Fields:    Translation:AnimalsCells
  98. Humphries DE, Stevens RL. Regulation of the gene that encodes the peptide core of heparin proteoglycan and other proteoglycans that are stored in the secretory granules of hematopoietic cells. Adv Exp Med Biol. 1992; 313:59-67. PMID: 1442270.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  99. Krilis SA, Austen KF, Macpherson JL, Nicodemus CF, Gurish MF, Stevens RL. Continuous release of secretory granule proteoglycans from a cell strain derived from the bone marrow of a patient with diffuse cutaneous mastocytosis. Blood. 1992 Jan 01; 79(1):144-51. PMID: 1728305.
    Citations: 2     Fields:    Translation:HumansCells
  100. Zon LI, Gurish MF, Stevens RL, Mather C, Reynolds DS, Austen KF, Orkin SH. GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem. 1991 Dec 05; 266(34):22948-53. PMID: 1744088.
    Citations: 40     Fields:    Translation:AnimalsCells
  101. McNeil HP, Austen KF, Somerville LL, Gurish MF, Stevens RL. Molecular cloning of the mouse mast cell protease-5 gene. A novel secretory granule protease expressed early in the differentiation of serosal mast cells. J Biol Chem. 1991 Oct 25; 266(30):20316-22. PMID: 1939089.
    Citations: 38     Fields:    Translation:AnimalsCells
  102. Serafin WE, Guidry UA, Dayton ET, Kamada MM, Stevens RL, Austen KF. Identification of aminopeptidase activity in the secretory granules of mouse mast cells. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):5984-8. PMID: 2068074; PMCID: PMC52006.
    Citations: 1     Fields:    Translation:AnimalsCells
  103. Gurish MF, Ghildyal N, Arm J, Austen KF, Avraham S, Reynolds D, Stevens RL. Cytokine mRNA are preferentially increased relative to secretory granule protein mRNA in mouse bone marrow-derived mast cells that have undergone IgE-mediated activation and degranulation. J Immunol. 1991 Mar 01; 146(5):1527-33. PMID: 1993842.
    Citations: 11     Fields:    Translation:AnimalsCells
  104. Stevens RL. Gene expression in different populations of mouse mast cells. Ann N Y Acad Sci. 1991; 629:31-7. PMID: 1952555.
    Citations: 1     Fields:    Translation:AnimalsCells
  105. Stevens RL. The importance of mouse, rat, and dog mast cell lines. Am J Respir Cell Mol Biol. 1990 Nov; 3(5):403-4. PMID: 2223097.
    Citations: 1     Fields:    Translation:AnimalsCells
  106. Stevens RL, Nicodemus CF, Avraham S. The gene that encodes the peptide core of secretory granule proteoglycans of haematopoietic cells. Biochem Soc Trans. 1990 Oct; 18(5):810-2. PMID: 2083683.
    Citations: 1     Fields:    Translation:AnimalsCells
  107. Caulfield JP, Hein A, Rothenberg ME, Owen WF, Soberman RJ, Stevens RL, Austen KF. A morphometric study of normodense and hypodense human eosinophils that are derived in vivo and in vitro. Am J Pathol. 1990 Jul; 137(1):27-41. PMID: 2196816; PMCID: PMC1877686.
    Citations: 8     Fields:    Translation:HumansCells
  108. Nicodemus CF, Avraham S, Austen KF, Purdy S, Jablonski J, Stevens RL. Characterization of the human gene that encodes the peptide core of secretory granule proteoglycans in promyelocytic leukemia HL-60 cells and analysis of the translated product. J Biol Chem. 1990 Apr 05; 265(10):5889-96. PMID: 2180935.
    Citations: 8     Fields:    Translation:HumansCells
  109. Reynolds DS, Stevens RL, Lane WS, Carr MH, Austen KF, Serafin WE. Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases. Proc Natl Acad Sci U S A. 1990 Apr; 87(8):3230-4. PMID: 2326280; PMCID: PMC53869.
    Citations: 68     Fields:    Translation:AnimalsCells
  110. Serafin WE, Reynolds DS, Rogelj S, Lane WS, Conder GA, Johnson SS, Austen KF, Stevens RL. Identification and molecular cloning of a novel mouse mucosal mast cell serine protease. J Biol Chem. 1990 Jan 05; 265(1):423-9. PMID: 1688433.
    Citations: 40     Fields:    Translation:AnimalsCells
  111. Reynolds DS, Gurley DS, Stevens RL, Sugarbaker DJ, Austen KF, Serafin WE. Cloning of cDNAs that encode human mast cell carboxypeptidase A, and comparison of the protein with mouse mast cell carboxypeptidase A and rat pancreatic carboxypeptidases. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9480-4. PMID: 2594780; PMCID: PMC298520.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  112. Reynolds DS, Stevens RL, Gurley DS, Lane WS, Austen KF, Serafin WE. Isolation and molecular cloning of mast cell carboxypeptidase A. A novel member of the carboxypeptidase gene family. J Biol Chem. 1989 Nov 25; 264(33):20094-9. PMID: 2584208.
    Citations: 32     Fields:    Translation:AnimalsCells
  113. Stevens RL, Austen KF. Recent advances in the cellular and molecular biology of mast cells. Immunol Today. 1989 Nov; 10(11):381-6. PMID: 2692594.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  114. Avraham S, Austen KF, Nicodemus CF, Gartner MC, Stevens RL. Cloning and characterization of the mouse gene that encodes the peptide core of secretory granule proteoglycans and expression of this gene in transfected rat-1 fibroblasts. J Biol Chem. 1989 Oct 05; 264(28):16719-26. PMID: 2777804.
    Citations: 2     Fields:    Translation:AnimalsCells
  115. Rothenberg ME, Petersen J, Stevens RL, Silberstein DS, McKenzie DT, Austen KF, Owen WF. IL-5-dependent conversion of normodense human eosinophils to the hypodense phenotype uses 3T3 fibroblasts for enhanced viability, accelerated hypodensity, and sustained antibody-dependent cytotoxicity. J Immunol. 1989 Oct 01; 143(7):2311-6. PMID: 2506282.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  116. Owen WF, Rothenberg ME, Petersen J, Weller PF, Silberstein D, Sheffer AL, Stevens RL, Soberman RJ, Austen KF. Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome. J Exp Med. 1989 Jul 01; 170(1):343-8. PMID: 2787385; PMCID: PMC2189380.
    Citations: 43     Fields:    Translation:HumansCells
  117. Dayton ET, Caulfield JP, Hein A, Austen KF, Stevens RL. Regulation of the growth rate of mouse fibroblasts by IL-3-activated mouse bone marrow-derived mast cells. J Immunol. 1989 Jun 15; 142(12):4307-13. PMID: 2786027.
    Citations: 11     Fields:    Translation:AnimalsCells
  118. Avraham S, Stevens RL, Nicodemus CF, Gartner MC, Austen KF, Weis JH. Molecular cloning of a cDNA that encodes the peptide core of a mouse mast cell secretory granule proteoglycan and comparison with the analogous rat and human cDNA. Proc Natl Acad Sci U S A. 1989 May; 86(10):3763-7. PMID: 2726751; PMCID: PMC287220.
    Citations: 14     Fields:    Translation:AnimalsCells
  119. Kamada MM, Michon J, Ritz J, Holldack J, Serafin WE, Austen KF, MacDermott RP, Stevens RL. Identification of carboxypeptidase and tryptic esterase activities that are complexed to proteoglycans in the secretory granules of human cloned natural killer cells. J Immunol. 1989 Jan 15; 142(2):609-15. PMID: 2911013.
    Citations: 7     Fields:    Translation:HumansCells
  120. Stevens RL, Kamada MM, Serafin WE. Structure and function of the family of proteoglycans that reside in the secretory granules of natural killer cells and other effector cells of the immune response. Curr Top Microbiol Immunol. 1989; 140:93-108. PMID: 2644078.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  121. Stevens RL. Mast cell proteoglycans. Prog Clin Biol Res. 1989; 297:131-43; discussion 143-4. PMID: 2685817.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  122. Rothenberg ME, Pomerantz JL, Owen WF, Avraham S, Soberman RJ, Austen KF, Stevens RL. Characterization of a human eosinophil proteoglycan, and augmentation of its biosynthesis and size by interleukin 3, interleukin 5, and granulocyte/macrophage colony stimulating factor. J Biol Chem. 1988 Sep 25; 263(27):13901-8. PMID: 2458354.
    Citations: 22     Fields:    Translation:HumansCells
  123. Reynolds DS, Serafin WE, Faller DV, Wall DA, Abbas AK, Dvorak AM, Austen KF, Stevens RL. Immortalization of murine connective tissue-type mast cells at multiple stages of their differentiation by coculture of splenocytes with fibroblasts that produce Kirsten sarcoma virus. J Biol Chem. 1988 Sep 05; 263(25):12783-91. PMID: 2457591.
    Citations: 17     Fields:    Translation:AnimalsCells
  124. Otsu K, Geary ES, Stevens RL. Aberrant regulation of the metabolism of the insulin receptor in Swarm rat chondrosarcoma chondrocytes. Biochem J. 1988 Aug 15; 254(1):203-9. PMID: 3052429; PMCID: PMC1135057.
    Citations: 3     Fields:    Translation:AnimalsCells
  125. Rothenberg ME, Owen WF, Silberstein DS, Woods J, Soberman RJ, Austen KF, Stevens RL. Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to human interleukin 3. J Clin Invest. 1988 Jun; 81(6):1986-92. PMID: 3133397; PMCID: PMC442652.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  126. Stevens RL, Avraham S, Gartner MC, Bruns GA, Austen KF, Weis JH. Isolation and characterization of a cDNA that encodes the peptide core of the secretory granule proteoglycan of human promyelocytic leukemia HL-60 cells. J Biol Chem. 1988 May 25; 263(15):7287-91. PMID: 2835370.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  127. Avraham S, Stevens RL, Gartner MC, Austen KF, Lalley PA, Weis JH. Isolation of a cDNA that encodes the peptide core of the secretory granule proteoglycan of rat basophilic leukemia-1 cells and assessment of its homology to the human analogue. J Biol Chem. 1988 May 25; 263(15):7292-6. PMID: 3366780.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  128. Katz HR, Dayton ET, Levi-Schaffer F, Benson AC, Austen KF, Stevens RL. Coculture of mouse IL-3-dependent mast cells with 3T3 fibroblasts stimulates synthesis of globopentaosylceramide (Forssman glycolipid) by fibroblasts and surface expression on both populations. J Immunol. 1988 May 01; 140(9):3090-7. PMID: 2452198.
    Citations: 3     Fields:    Translation:AnimalsCells
  129. Stevens RL, Fox CC, Lichtenstein LM, Austen KF. Identification of chondroitin sulfate E proteoglycans and heparin proteoglycans in the secretory granules of human lung mast cells. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2284-7. PMID: 3353378; PMCID: PMC279975.
    Citations: 31     Fields:    Translation:HumansCells
  130. Heavey DJ, Ernst PB, Stevens RL, Befus AD, Bienenstock J, Austen KF. Generation of leukotriene C4, leukotriene B4, and prostaglandin D2 by immunologically activated rat intestinal mucosa mast cells. J Immunol. 1988 Mar 15; 140(6):1953-7. PMID: 2450136.
    Citations: 32     Fields:    Translation:AnimalsCells
  131. Schmidt RE, Caulfield JP, Michon J, Hein A, Kamada MM, MacDermott RP, Stevens RL, Ritz J. T11/CD2 activation of cloned human natural killer cells results in increased conjugate formation and exocytosis of cytolytic granules. J Immunol. 1988 Feb 01; 140(3):991-1002. PMID: 3276787.
    Citations: 18     Fields:    Translation:HumansCells
  132. Dayton ET, Pharr P, Ogawa M, Serafin WE, Austen KF, Levi-Schaffer F, Stevens RL. 3T3 fibroblasts induce cloned interleukin 3-dependent mouse mast cells to resemble connective tissue mast cells in granular constituency. Proc Natl Acad Sci U S A. 1988 Jan; 85(2):569-72. PMID: 3257570; PMCID: PMC279592.
    Citations: 24     Fields:    Translation:AnimalsCells
  133. Rothenberg ME, Owen WF, Stevens RL. Ocular allergy. Mast cells and eosinophils. Int Ophthalmol Clin. 1988; 28(4):267-74. PMID: 3053485.
    Citations:    Fields:    Translation:HumansCells
  134. Serafin WE, Dayton ET, Gravallese PM, Austen KF, Stevens RL. Carboxypeptidase A in mouse mast cells. Identification, characterization, and use as a differentiation marker. J Immunol. 1987 Dec 01; 139(11):3771-6. PMID: 3680950.
    Citations: 26     Fields:    Translation:AnimalsCells
  135. Levi-Schaffer F, Dayton ET, Austen KF, Hein A, Caulfield JP, Gravallese PM, Liu FT, Stevens RL. Mouse bone marrow-derived mast cells cocultured with fibroblasts. Morphology and stimulation-induced release of histamine, leukotriene B4, leukotriene C4, and prostaglandin D2. J Immunol. 1987 Nov 15; 139(10):3431-41. PMID: 2445814.
    Citations: 20     Fields:    Translation:AnimalsCells
  136. Rothenberg ME, Owen WF, Silberstein DS, Soberman RJ, Austen KF, Stevens RL. Eosinophils cocultured with endothelial cells have increased survival and functional properties. Science. 1987 Aug 07; 237(4815):645-7. PMID: 3110954.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  137. Stevens RL, Otsu K, Weis JH, Tantravahi RV, Austen KF, Henkart PA, Galli MC, Reynolds CW. Co-sedimentation of chondroitin sulfate A glycosaminoglycans and proteoglycans with the cytolytic secretory granules of rat large granular lymphocyte (LGL) tumor cells, and identification of a mRNA in normal and transformed LGL that encodes proteoglycans. J Immunol. 1987 Aug 01; 139(3):863-8. PMID: 3110286.
    Citations: 8     Fields:    Translation:AnimalsCells
  138. Levi-Schaffer F, Austen KF, Caulfield JP, Hein A, Gravallese PM, Stevens RL. Co-culture of human lung-derived mast cells with mouse 3T3 fibroblasts: morphology and IgE-mediated release of histamine, prostaglandin D2, and leukotrienes. J Immunol. 1987 Jul 15; 139(2):494-500. PMID: 2439587.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  139. Owen WF, Rothenberg ME, Silberstein DS, Gasson JC, Stevens RL, Austen KF, Soberman RJ. Regulation of human eosinophil viability, density, and function by granulocyte/macrophage colony-stimulating factor in the presence of 3T3 fibroblasts. J Exp Med. 1987 Jul 01; 166(1):129-41. PMID: 3110347; PMCID: PMC2188636.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  140. Rothenberg ME, Caulfield JP, Austen KF, Hein A, Edmiston K, Newburger PE, Stevens RL. Biochemical and morphological characterization of basophilic leukocytes from two patients with myelogenous leukemia. J Immunol. 1987 Apr 15; 138(8):2616-25. PMID: 3104470.
    Citations: 3     Fields:    Translation:HumansCells
  141. Stevens RL, Rothenberg ME, Levi-Schaffer F, Austen KF. Ontogeny of in vitro-differentiated mouse mast cells. Fed Proc. 1987 Apr; 46(5):1915-9. PMID: 3549363.
    Citations: 2     Fields:    Translation:AnimalsCells
  142. Otsu K, Nakano T, Kanakura Y, Asai H, Katz HR, Austen KF, Stevens RL, Galli SJ, Kitamura Y. Phenotypic changes of bone marrow-derived mast cells after intraperitoneal transfer into W/Wv mice that are genetically deficient in mast cells. J Exp Med. 1987 Mar 01; 165(3):615-27. PMID: 3102674; PMCID: PMC2188296.
    Citations: 28     Fields:    Translation:AnimalsCells
  143. Akiyama F, Stevens RL, Hayashi S, Swann DA, Binette JP, Caterson B, Schmid K, Van Halbeek H, Mutsaers JH, Gerwig GJ, et al. The structures of N- and O-glycosidic carbohydrate chains of a chondroitin sulfate proteoglycan isolated from the media of the human aorta. Arch Biochem Biophys. 1987 Feb 01; 252(2):574-90. PMID: 3813552.
    Citations: 1     Fields:    Translation:HumansCells
  144. Tantravahi RV, Stevens RL, Austen KF, Weis JH. A single gene in mast cells encodes the core peptides of heparin and chondroitin sulfate proteoglycans. Proc Natl Acad Sci U S A. 1986 Dec; 83(23):9207-10. PMID: 2947243; PMCID: PMC387104.
    Citations: 22     Fields:    Translation:AnimalsCells
  145. Serafin WE, Katz HR, Austen KF, Stevens RL. Complexes of heparin proteoglycans, chondroitin sulfate E proteoglycans, and [3H]diisopropyl fluorophosphate-binding proteins are exocytosed from activated mouse bone marrow-derived mast cells. J Biol Chem. 1986 Nov 15; 261(32):15017-21. PMID: 3095324.
    Citations: 26     Fields:    Translation:AnimalsCells
  146. Katz HR, Austen KF, Caterson B, Stevens RL. Secretory granules of heparin-containing rat serosal mast cells also possess highly sulfated chondroitin sulfate proteoglycans. J Biol Chem. 1986 Oct 15; 261(29):13393-6. PMID: 3531203.
    Citations: 15     Fields:    Translation:AnimalsCells
  147. Levi-Schaffer F, Austen KF, Gravallese PM, Stevens RL. Coculture of interleukin 3-dependent mouse mast cells with fibroblasts results in a phenotypic change of the mast cells. Proc Natl Acad Sci U S A. 1986 Sep; 83(17):6485-8. PMID: 3462707; PMCID: PMC386528.
    Citations: 78     Fields:    Translation:AnimalsCells
  148. Stevens RL, Lee TD, Seldin DC, Austen KF, Befus AD, Bienenstock J. Intestinal mucosal mast cells from rats infected with Nippostrongylus brasiliensis contain protease-resistant chondroitin sulfate di-B proteoglycans. J Immunol. 1986 Jul 01; 137(1):291-5. PMID: 3086452.
    Citations: 41     Fields:    Translation:AnimalsCells
  149. Spiro RC, Parsons WG, Perry SK, Caulfield JP, Hein A, Reisfeld RA, Harper JR, Austen KF, Stevens RL. Inhibition of post-translational modification and surface expression of a melanoma-associated chondroitin sulfate proteoglycan by diethylcarbamazine or ammonium chloride. J Biol Chem. 1986 Apr 15; 261(11):5121-9. PMID: 3514609.
    Citations: 3     Fields:    Translation:HumansCells
  150. Seldin DC, Caulfield JP, Hein A, Osathanondh R, Nabel G, Schlossman SF, Stevens RL, Austen KF. Biochemical and phenotypic characterization of human basophilic cells derived from dispersed fetal liver with murine T cell factors. J Immunol. 1986 Mar 15; 136(6):2222-30. PMID: 2419426.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  151. Stevens RL, Hasumura S, Parsons WG, Cheng SY. The identification of a plasma membrane 3,3',5-triiodo-L-thyronine binding protein on the cultured Swarm rat chondrosarcoma chondrocyte and the lack of its up-regulation by insulin in vitro. Endocrinology. 1986 Feb; 118(2):573-82. PMID: 3002756.
    Citations: 1     Fields:    Translation:AnimalsCells
  152. Stevens RL. Secretory granule proteoglycans of mast cells and natural killer cells. Ciba Found Symp. 1986; 124:272-85. PMID: 3816420.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  153. MacDermott RP, Schmidt RE, Caulfield JP, Hein A, Bartley GT, Ritz J, Schlossman SF, Austen KF, Stevens RL. Proteoglycans in cell-mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from human cloned natural killer cells during target cell lysis. J Exp Med. 1985 Dec 01; 162(6):1771-87. PMID: 3934316; PMCID: PMC2187999.
    Citations: 29     Fields:    Translation:HumansCells
  154. Stevens RL, Otsu K, Austen KF. Purification and analysis of the core protein of the protease-resistant intracellular chondroitin sulfate E proteoglycan from the interleukin 3-dependent mouse mast cell. J Biol Chem. 1985 Nov 15; 260(26):14194-200. PMID: 3932350.
    Citations: 17     Fields:    Translation:AnimalsCells
  155. Levi-Schaffer F, Austen KF, Caulfield JP, Hein A, Bloes WF, Stevens RL. Fibroblasts maintain the phenotype and viability of the rat heparin-containing mast cell in vitro. J Immunol. 1985 Nov; 135(5):3454-62. PMID: 2413121.
    Citations: 28     Fields:    Translation:AnimalsCells
  156. Schmidt RE, MacDermott RP, Bartley G, Bertovich M, Amato DA, Austen KF, Schlossman SF, Stevens RL, Ritz J. Specific release of proteoglycans from human natural killer cells during target lysis. Nature. 1985 Nov 21-27; 318(6043):289-91. PMID: 4069203.
    Citations: 26     Fields:    Translation:HumansCells
  157. Seldin DC, Austen KF, Stevens RL. Purification and characterization of protease-resistant secretory granule proteoglycans containing chondroitin sulfate di-B and heparin-like glycosaminoglycans from rat basophilic leukemia cells. J Biol Chem. 1985 Sep 15; 260(20):11131-9. PMID: 2411730.
    Citations: 22     Fields:    Translation:AnimalsCells
  158. Katz HR, Stevens RL, Austen KF. Heterogeneity of mammalian mast cells differentiated in vivo and in vitro. J Allergy Clin Immunol. 1985 Aug; 76(2 Pt 2):250-9. PMID: 2410474.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  159. Seldin DC, Adelman S, Austen KF, Stevens RL, Hein A, Caulfield JP, Woodbury RG. Homology of the rat basophilic leukemia cell and the rat mucosal mast cell. Proc Natl Acad Sci U S A. 1985 Jun; 82(11):3871-5. PMID: 3923482; PMCID: PMC397890.
    Citations: 47     Fields:    Translation:AnimalsCells
  160. Stevens RL, Parsons WG, Austen KF, Hein A, Caulfield JP. Novel inhibition of proteoglycan synthesis and exocytosis by diethylcarbamazine in the Swarm rat chondrocyte. J Biol Chem. 1985 May 10; 260(9):5777-86.