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Daniel Adino Goodenough, Ph.D.

Title
Institution
Department
Address
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Mentoring
Curriculum Development for the Human Body Course at Harvard Medical School
Summer, 08/21/99 - 08/31/99
Untitled
Soma Weiss, 06/21/99 - 08/31/99
Curriculum Development for the Human Body Course at Harvard Medical School
Summer, 06/21/99 - 08/31/99

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM028932 (GOODENOUGH, DANIEL A.) Apr 1, 1981 - Mar 31, 1995
    NIH/NIGMS
    MOLECULAR BIOLOGY OF ZONULAE OCCLUDENTES
    Role: Principal Investigator
  2. R01EY002430 (PAUL, DAVID L) Mar 1, 1978 - Mar 31, 2013
    NIH/NEI
    Connexin Molecular Biology in the Lens and Ciliary Epithelium
    Role: Co-Principal Investigator
  3. R01GM018974 (GOODENOUGH, DANIEL A.) Jan 1, 1975 - Dec 31, 2006
    NIH/NIGMS
    Molecular Biology of Intercellular Junctions
    Role: Principal Investigator
  4. R37GM018974 (GOODENOUGH, DANIEL A.) Jan 1, 1975 - Dec 31, 1997
    NIH/NIGMS
    MOLECULAR BIOLOGY OF INTERCELLULAR COMMUNICATION
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. White AA, Logghe HJ, Goodenough DA, Barnes LL, Hallward A, Allen IM, Green DW, Krupat E, Llerena-Quinn R. Self-Awareness and Cultural Identity as an Effort to Reduce Bias in Medicine. J Racial Ethn Health Disparities. 2018 Feb; 5(1):34-49. PMID: 28342029.
    Citations: 3     Fields:    
  2. Chai Z, Goodenough DA, Paul DL. Cx50 requires an intact PDZ-binding motif and ZO-1 for the formation of functional intercellular channels. Mol Biol Cell. 2011 Dec; 22(23):4503-12. PMID: 21965293.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  3. Magnotti LM, Goodenough DA, Paul DL. Deletion of oligodendrocyte Cx32 and astrocyte Cx43 causes white matter vacuolation, astrocyte loss and early mortality. Glia. 2011 Jul; 59(7):1064-74. PMID: 21538560.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  4. Magnotti LM, Goodenough DA, Paul DL. Functional heterotypic interactions between astrocyte and oligodendrocyte connexins. Glia. 2011 Jan; 59(1):26-34. PMID: 21046554.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  5. Hou J, Goodenough DA. Claudin-16 and claudin-19 function in the thick ascending limb. Curr Opin Nephrol Hypertens. 2010 Sep; 19(5):483-8. PMID: 20616717.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  6. Hou J, Renigunta A, Gomes AS, Hou M, Paul DL, Waldegger S, Goodenough DA. Claudin-16 and claudin-19 interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium. Proc Natl Acad Sci U S A. 2009 Sep 08; 106(36):15350-5. PMID: 19706394.
    Citations: 65     Fields:    Translation:AnimalsCells
  7. Goodenough DA, Paul DL. Gap junctions. Cold Spring Harb Perspect Biol. 2009 Jul; 1(1):a002576. PMID: 20066080.
    Citations: 138     Fields:    Translation:HumansAnimalsCells
  8. Shan Q, Himmerkus N, Hou J, Goodenough DA, Bleich M. Insights into driving forces and paracellular permeability from claudin-16 knockdown mouse. Ann N Y Acad Sci. 2009 May; 1165:148-51. PMID: 19538300.
    Citations: 4     Fields:    Translation:AnimalsCells
  9. Calera MR, Wang Z, Sanchez-Olea R, Paul DL, Civan MM, Goodenough DA. Depression of intraocular pressure following inactivation of connexin43 in the nonpigmented epithelium of the ciliary body. Invest Ophthalmol Vis Sci. 2009 May; 50(5):2185-93. PMID: 19168903.
    Citations: 7     Fields:    Translation:AnimalsCells
  10. Himmerkus N, Shan Q, Goerke B, Hou J, Goodenough DA, Bleich M. Salt and acid-base metabolism in claudin-16 knockdown mice: impact for the pathophysiology of FHHNC patients. Am J Physiol Renal Physiol. 2008 Dec; 295(6):F1641-7. PMID: 18784260.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  11. Hou J, Renigunta A, Konrad M, Gomes AS, Schneeberger EE, Paul DL, Waldegger S, Goodenough DA. Claudin-16 and claudin-19 interact and form a cation-selective tight junction complex. J Clin Invest. 2008 Feb; 118(2):619-28. PMID: 18188451.
    Citations: 88     Fields:    Translation:AnimalsCells
  12. Konrad M, Hou J, Weber S, Dötsch J, Kari JA, Seeman T, Kuwertz-Bröking E, Peco-Antic A, Tasic V, Dittrich K, Alshaya HO, von Vigier RO, Gallati S, Goodenough DA, Schaller A. CLDN16 genotype predicts renal decline in familial hypomagnesemia with hypercalciuria and nephrocalcinosis. J Am Soc Nephrol. 2008 Jan; 19(1):171-81. PMID: 18003771.
    Citations: 31     Fields:    Translation:HumansCells
  13. Hou J, Shan Q, Wang T, Gomes AS, Yan Q, Paul DL, Bleich M, Goodenough DA. Transgenic RNAi depletion of claudin-16 and the renal handling of magnesium. J Biol Chem. 2007 Jun 08; 282(23):17114-22. PMID: 17442678.
    Citations: 45     Fields:    Translation:AnimalsCells
  14. Menichella DM, Majdan M, Awatramani R, Goodenough DA, Sirkowski E, Scherer SS, Paul DL. Genetic and physiological evidence that oligodendrocyte gap junctions contribute to spatial buffering of potassium released during neuronal activity. J Neurosci. 2006 Oct 25; 26(43):10984-91. PMID: 17065440.
    Citations: 49     Fields:    Translation:AnimalsCells
  15. Calera MR, Topley HL, Liao Y, Duling BR, Paul DL, Goodenough DA. Connexin43 is required for production of the aqueous humor in the murine eye. J Cell Sci. 2006 Nov 01; 119(Pt 21):4510-9. PMID: 17046998.
    Citations: 14     Fields:    Translation:AnimalsCells
  16. Hou J, Gomes AS, Paul DL, Goodenough DA. Study of claudin function by RNA interference. J Biol Chem. 2006 Nov 24; 281(47):36117-23. PMID: 17018523.
    Citations: 73     Fields:    Translation:AnimalsCells
  17. Wong CW, Christen T, Roth I, Chadjichristos CE, Derouette JP, Foglia BF, Chanson M, Goodenough DA, Kwak BR. Connexin37 protects against atherosclerosis by regulating monocyte adhesion. Nat Med. 2006 Aug; 12(8):950-4. PMID: 16862155.
    Citations: 84     Fields:    Translation:AnimalsCells
  18. Yiou R, Goodenough D. Applying problem-based learning to the teaching of anatomy: the example of Harvard Medical School. Surg Radiol Anat. 2006 May; 28(2):189-94. PMID: 16521048.
    Citations: 3     Fields:    Translation:Humans
  19. Medici D, Hay ED, Goodenough DA. Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition. Mol Biol Cell. 2006 Apr; 17(4):1871-9. PMID: 16467384.
    Citations: 82     Fields:    Translation:AnimalsCells
  20. Hou J, Paul DL, Goodenough DA. Paracellin-1 and the modulation of ion selectivity of tight junctions. J Cell Sci. 2005 Nov 01; 118(Pt 21):5109-18. PMID: 16234325.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  21. Martinez-Wittinghan FJ, Sellitto C, White TW, Mathias RT, Paul D, Goodenough DA. Lens gap junctional coupling is modulated by connexin identity and the locus of gene expression. Invest Ophthalmol Vis Sci. 2004 Oct; 45(10):3629-37. PMID: 15452070.
    Citations: 24     Fields:    Translation:AnimalsCells
  22. Stout C, Goodenough DA, Paul DL. Connexins: functions without junctions. Curr Opin Cell Biol. 2004 Oct; 16(5):507-12. PMID: 15363800.
    Citations: 60     Fields:    Translation:Cells
  23. Peter Y, Goodenough D. Claudins. Curr Biol. 2004 Apr 20; 14(8):R293-4. PMID: 15084294.
    Citations: 4     Fields:    Translation:Cells
  24. Menichella DM, Goodenough DA, Sirkowski E, Scherer SS, Paul DL. Connexins are critical for normal myelination in the CNS. J Neurosci. 2003 Jul 02; 23(13):5963-73. PMID: 12843301.
    Citations: 79     Fields:    Translation:AnimalsCells
  25. Goodenough DA, Paul DL. Beyond the gap: functions of unpaired connexon channels. Nat Rev Mol Cell Biol. 2003 Apr; 4(4):285-94. PMID: 12671651.
    Citations: 211     Fields:    Translation:HumansAnimalsCells
  26. Figueroa XF, Paul DL, Simon AM, Goodenough DA, Day KH, Damon DN, Duling BR. Central role of connexin40 in the propagation of electrically activated vasodilation in mouse cremasteric arterioles in vivo. Circ Res. 2003 Apr 18; 92(7):793-800. PMID: 12637364.
    Citations: 48     Fields:    Translation:Animals
  27. Tang VW, Goodenough DA. Paracellular ion channel at the tight junction. Biophys J. 2003 Mar; 84(3):1660-73. PMID: 12609869.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  28. Jeansonne B, Lu Q, Goodenough DA, Chen YH. Claudin-8 interacts with multi-PDZ domain protein 1 (MUPP1) and reduces paracellular conductance in epithelial cells. Cell Mol Biol (Noisy-le-grand). 2003 Feb; 49(1):13-21. PMID: 12839333.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  29. Goodenough, D.A. Problem-based learning, resources and science in medical education. Biochem.Mol.Biol.Edu. 2003; 31:190-191.
  30. Landesman Y, Postma FR, Goodenough DA, Paul DL. Multiple connexins contribute to intercellular communication in the Xenopus embryo. J Cell Sci. 2003 Jan 01; 116(Pt 1):29-38. PMID: 12456713.
    Citations: 5     Fields:    Translation:AnimalsCells
  31. Deans MR, Volgyi B, Goodenough DA, Bloomfield SA, Paul DL. Connexin36 is essential for transmission of rod-mediated visual signals in the mammalian retina. Neuron. 2002 Nov 14; 36(4):703-12. PMID: 12441058.
    Citations: 141     Fields:    Translation:AnimalsCells
  32. Landesman Y, Goodenough DA, Paul DL. Xwnt-2 (Xwnt-2b) is maternally expressed in Xenopus oocytes and embryos. Biochim Biophys Acta. 2002 Jul 19; 1576(3):265-8. PMID: 12084573.
    Citations:    Fields:    Translation:AnimalsCells
  33. Goodenough D, Postma F. Pulse-chase in the light microscope. Mol Interv. 2002 Jun; 2(3):132-4. PMID: 14993371.
    Citations:    Fields:    Translation:HumansCells
  34. Chen YH, Lu Q, Goodenough DA, Jeansonne B. Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells. Mol Biol Cell. 2002 Apr; 13(4):1227-37. PMID: 11950934.
    Citations: 39     Fields:    Translation:AnimalsCells
  35. Chivian E, Epstein PR, Ford TE, Goodenough DA, Hu H. Global issues in medical education. Lancet. 2002 Feb 23; 359(9307):714. PMID: 11879904.
    Citations:    Fields:    Translation:Humans
  36. Goodenough, D.A. Understanding CellSpeak. Trands Cell Biol. 2002; 12:289-290.
  37. Goodenough, D.A. and F. Postma . Pulse-chase in the light microscope. Mol. Intervent. 2002; 2:132-132.
  38. Goodenough, D.A. and F. Postma. Pulse-chase in the light microscope. Mol. Intervent. 2002; 2:132-134.
  39. Goodenough, D.A. Understanding CellSpeak. Trends. Cell Biol. 2002; 12:289-290.
  40. White TW, Sellitto C, Paul DL, Goodenough DA. Prenatal lens development in connexin43 and connexin50 double knockout mice. Invest Ophthalmol Vis Sci. 2001 Nov; 42(12):2916-23. PMID: 11687537.
    Citations: 12     Fields:    Translation:AnimalsCells
  41. Cason N, White TW, Cheng S, Goodenough DA, Valdimarsson G. Molecular cloning, expression analysis, and functional characterization of connexin44.1: a zebrafish lens gap junction protein. Dev Dyn. 2001 Jun; 221(2):238-47. PMID: 11376491.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  42. Carabatsos MJ, Sellitto C, Goodenough DA, Albertini DF. Oocyte-granulosa cell heterologous gap junctions are required for the coordination of nuclear and cytoplasmic meiotic competence. Dev Biol. 2000 Oct 15; 226(2):167-79. PMID: 11023678.
    Citations: 56     Fields:    Translation:AnimalsCells
  43. Landesman Y, Goodenough DA, Paul DL. Gap junctional communication in the early Xenopus embryo. J Cell Biol. 2000 Aug 21; 150(4):929-36. PMID: 10953017.
    Citations: 6     Fields:    Translation:AnimalsCells
  44. Ryeom SW, Paul D, Goodenough DA. Truncation mutants of the tight junction protein ZO-1 disrupt corneal epithelial cell morphology. Mol Biol Cell. 2000 May; 11(5):1687-96. PMID: 10793144.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  45. Chen Yh, Lu Q, Schneeberger EE, Goodenough DA. Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells. Mol Biol Cell. 2000 Mar; 11(3):849-62. PMID: 10712504.
    Citations: 65     Fields:    Translation:AnimalsCells
  46. Muresan Z, Paul DL, Goodenough DA. Occludin 1B, a variant of the tight junction protein occludin. Mol Biol Cell. 2000 Feb; 11(2):627-34. PMID: 10679019.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  47. Keon BH, Jedrzejewski PT, Paul DL, Goodenough DA. Isoform specific expression of the neuronal F-actin binding protein, drebrin, in specialized cells of stomach and kidney epithelia. J Cell Sci. 2000 Jan; 113 Pt 2:325-36. PMID: 10633083.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  48. Wong V, Goodenough DA. Paracellular channels! Science. 1999 Jul 02; 285(5424):62. PMID: 10428705.
    Citations: 10     Fields:    Translation:HumansCells
  49. Landesman Y, White TW, Starich TA, Shaw JE, Goodenough DA, Paul DL. Innexin-3 forms connexin-like intercellular channels. J Cell Sci. 1999 Jul; 112 ( Pt 14):2391-6. PMID: 10381394.
    Citations: 18     Fields:    Translation:AnimalsCells
  50. White TW, Deans MR, O'Brien J, Al-Ubaidi MR, Goodenough DA, Ripps H, Bruzzone R. Functional characteristics of skate connexin35, a member of the gamma subfamily of connexins expressed in the vertebrate retina. Eur J Neurosci. 1999 Jun; 11(6):1883-90. PMID: 10336656.
    Citations: 30     Fields:    Translation:AnimalsCells
  51. Goodenough DA. Plugging the leaks. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):319-21. PMID: 9892627.
    Citations: 16     Fields:    Translation:AnimalsCells
  52. Goodenough, D.A., A.M. Simon and D.L. Paul . Gap junctional intercellular communication in the mouse ovarian follicle. In: Gap junction-mediated intercellular signalling in health and disease. Novartis Foundation Symposium 219. 1999; 226-235.
  53. Goodenough, D.A. Plugging the leaks. Proc. Natl. Acad. Sci. 1999; 96:319-321.
  54. Goodenough DA, Simon AM, Paul DL. Gap junctional intercellular communication in the mouse ovarian follicle. Novartis Found Symp. 1999; 219:226-35; discussion 235-40. PMID: 10207907.
    Citations: 6     Fields:    Translation:AnimalsCells
  55. Simon AM, Goodenough DA. Diverse functions of vertebrate gap junctions. Trends Cell Biol. 1998 Dec; 8(12):477-83. PMID: 9861669.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  56. White TW, Goodenough DA, Paul DL. Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts. J Cell Biol. 1998 Nov 02; 143(3):815-25. PMID: 9813099.
    Citations: 120     Fields:    Translation:HumansAnimals
  57. Jiang JX, Goodenough DA. Phosphorylation of lens-fiber connexins in lens organ cultures. Eur J Biochem. 1998 Jul 01; 255(1):37-44. PMID: 9692898.
    Citations: 10     Fields:    Translation:AnimalsCells
  58. Perkins GA, Goodenough DA, Sosinsky GE. Formation of the gap junction intercellular channel requires a 30 degree rotation for interdigitating two apposing connexons. J Mol Biol. 1998 Mar 27; 277(2):171-7. PMID: 9514740.
    Citations: 19     Fields:    Translation:Cells
  59. Merzdorf CS, Chen YH, Goodenough DA. Formation of functional tight junctions in Xenopus embryos. Dev Biol. 1998 Mar 15; 195(2):187-203. PMID: 9520334.
    Citations: 9     Fields:    Translation:AnimalsCells
  60. Jiang JX, Goodenough DA. Retroviral expression of connexins in embryonic chick lens. Invest Ophthalmol Vis Sci. 1998 Mar; 39(3):537-43. PMID: 9501864.
    Citations: 4     Fields:    Translation:AnimalsCells
  61. Simon AM, Goodenough DA, Paul DL. Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block. Curr Biol. 1998 Feb 26; 8(5):295-8. PMID: 9501069.
    Citations: 79     Fields:    Translation:Animals
  62. Perkins, G.A., D.A. Goodenough, and G.E. Sosinsky. Structural considerations for connexon docking. In: Gap Junctions, Werner, R., ed. 1998; 13-17.
  63. Percac S, Goodenough DA. Problem based teaching and learning as a bridge from basic anatomy to clinical clerkships. Surg Radiol Anat. 1998; 20(3):203-7. PMID: 9706680.
    Citations: 3     Fields:    Translation:Humans
  64. Chen Y, Merzdorf C, Paul DL, Goodenough DA. COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryos. J Cell Biol. 1997 Aug 25; 138(4):891-9. PMID: 9265654.
    Citations: 73     Fields:    Translation:AnimalsCells
  65. Merzdorf CS, Goodenough DA. Localization of a novel 210 kDa protein in Xenopus tight junctions. J Cell Sci. 1997 Apr; 110 ( Pt 8):1005-12. PMID: 9152026.
    Citations:    Fields:    Translation:AnimalsCells
  66. Simon AM, Goodenough DA, Li E, Paul DL. Female infertility in mice lacking connexin 37. Nature. 1997 Feb 06; 385(6616):525-9. PMID: 9020357.
    Citations: 116     Fields:    Translation:AnimalsCells
  67. Perkins G, Goodenough D, Sosinsky G. Three-dimensional structure of the gap junction connexon. Biophys J. 1997 Feb; 72(2 Pt 1):533-44. PMID: 9017184.
    Citations: 18     Fields:    Translation:AnimalsCells
  68. Beatch M, Jesaitis LA, Gallin WJ, Goodenough DA, Stevenson BR. The tight junction protein ZO-2 contains three PDZ (PSD-95/Discs-Large/ZO-1) domains and an alternatively spliced region. J Biol Chem. 1996 Oct 18; 271(42):25723-6. PMID: 8824195.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  69. Bruzzone R, White TW, Goodenough DA. The cellular Internet: on-line with connexins. Bioessays. 1996 Sep; 18(9):709-18. PMID: 8831287.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  70. Jiang JX, Goodenough DA. Heteromeric connexons in lens gap junction channels. Proc Natl Acad Sci U S A. 1996 Feb 06; 93(3):1287-91. PMID: 8577756.
    Citations: 65     Fields:    Translation:AnimalsCells
  71. Goodenough DA, Goliger JA, Paul DL. Connexins, connexons, and intercellular communication. Annu Rev Biochem. 1996; 65:475-502. PMID: 8811187.
    Citations: 237     Fields:    Translation:AnimalsCells
  72. Donaldson PJ, Dong Y, Roos M, Green C, Goodenough DA, Kistler J. Changes in lens connexin expression lead to increased gap junctional voltage dependence and conductance. Am J Physiol. 1995 Sep; 269(3 Pt 1):C590-600. PMID: 7573388.
    Citations: 11     Fields:    Translation:AnimalsCells
  73. Bruzzone R, Goodenough DA. Gap junctions: ductin or connexins--which component is the critical one? Bioessays. 1995 Aug; 17(8):744-5. PMID: 7661855.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  74. Ghoshroy S, Goodenough DA, Sosinsky GE. Preparation, characterization, and structure of half gap junctional layers split with urea and EGTA. J Membr Biol. 1995 Jul; 146(1):15-28. PMID: 7563034.
    Citations: 19     Fields:    Translation:AnimalsCells
  75. White TW, Paul DL, Goodenough DA, Bruzzone R. Functional analysis of selective interactions among rodent connexins. Mol Biol Cell. 1995 Apr; 6(4):459-70. PMID: 7542941.
    Citations: 49     Fields:    Translation:AnimalsCells
  76. Jiang JX, White TW, Goodenough DA. Changes in connexin expression and distribution during chick lens development. Dev Biol. 1995 Apr; 168(2):649-61. PMID: 7729595.
    Citations: 15     Fields:    Translation:AnimalsCells
  77. Paul DL, Yu K, Bruzzone R, Gimlich RL, Goodenough DA. Expression of a dominant negative inhibitor of intercellular communication in the early Xenopus embryo causes delamination and extrusion of cells. Development. 1995 Feb; 121(2):371-81. PMID: 7768179.
    Citations: 14     Fields:    Translation:AnimalsCells
  78. White TW, Bruzzone R, Goodenough DA, Paul DL. Voltage gating of connexins. Nature. 1994 Sep 15; 371(6494):208-9. PMID: 8078580.
    Citations: 19     Fields:    Translation:AnimalsCells
  79. White TW, Bruzzone R, Wolfram S, Paul DL, Goodenough DA. Selective interactions among the multiple connexin proteins expressed in the vertebrate lens: the second extracellular domain is a determinant of compatibility between connexins. J Cell Biol. 1994 May; 125(4):879-92. PMID: 8188753.
    Citations: 79     Fields:    Translation:AnimalsCells
  80. Jesaitis LA, Goodenough DA. Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein. J Cell Biol. 1994 Mar; 124(6):949-61. PMID: 8132716.
    Citations: 105     Fields:    Translation:AnimalsCells
  81. Jiang JX, White TW, Goodenough DA, Paul DL. Molecular cloning and functional characterization of chick lens fiber connexin 45.6. Mol Biol Cell. 1994 Mar; 5(3):363-73. PMID: 8049527.
    Citations: 25     Fields:    Translation:AnimalsCells
  82. Jiang JX, Paul DL, Goodenough DA. Posttranslational phosphorylation of lens fiber connexin46: a slow occurrence. Invest Ophthalmol Vis Sci. 1993 Dec; 34(13):3558-65. PMID: 8258513.
    Citations: 14     Fields:    Translation:AnimalsCells
  83. Musil LS, Goodenough DA. Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ER. Cell. 1993 Sep 24; 74(6):1065-77. PMID: 7691412.
    Citations: 142     Fields:    Translation:AnimalsCells
  84. Goodenough DA, Musil LS. Gap junctions and tissue business: problems and strategies for developing specific functional reagents. J Cell Sci Suppl. 1993; 17:133-8. PMID: 8144689.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  85. Harris AL, Walter A, Paul D, Goodenough DA, Zimmerberg J. Ion channels in single bilayers induced by rat connexin32. Brain Res Mol Brain Res. 1992 Oct; 15(3-4):269-80. PMID: 1279354.
    Citations: 7     Fields:    Translation:AnimalsCells
  86. White TW, Bruzzone R, Goodenough DA, Paul DL. Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70. Mol Biol Cell. 1992 Jul; 3(7):711-20. PMID: 1325220.
    Citations: 97     Fields:    Translation:AnimalsCells
  87. Goodenough DA. The crystalline lens. A system networked by gap junctional intercellular communication. Semin Cell Biol. 1992 Feb; 3(1):49-58. PMID: 1320431.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  88. Goodenough, D.A. The crystalline lens: a system networked by gap junctional intercellular communication. in Seminars in Cell Biology, N.B. Gilula, ed. 1992; 3:49-58.
  89. Musil LS, Goodenough DA. Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctional plaques. J Cell Biol. 1991 Dec; 115(5):1357-74. PMID: 1659577.
    Citations: 190     Fields:    Translation:Cells
  90. Paul DL, Ebihara L, Takemoto LJ, Swenson KI, Goodenough DA. Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes. J Cell Biol. 1991 Nov; 115(4):1077-89. PMID: 1659572.
    Citations: 190     Fields:    Translation:AnimalsCells
  91. Sosinsky GE, Baker TS, Caspar DL, Goodenough DA. Correlation analysis of gap junction lattice images. Biophys J. 1990 Nov; 58(5):1213-26. PMID: 2291941.
    Citations: 6     Fields:    Translation:Cells
  92. Musil LS, Cunningham BA, Edelman GM, Goodenough DA. Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines. J Cell Biol. 1990 Nov; 111(5 Pt 1):2077-88. PMID: 2172261.
    Citations: 148     Fields:    Translation:AnimalsCells
  93. Musil LS, Goodenough DA. Gap junctional intercellular communication and the regulation of connexin expression and function. Curr Opin Cell Biol. 1990 Oct; 2(5):875-80. PMID: 1964569.
    Citations: 16     Fields:    Translation:AnimalsCells
  94. Beyer EC, Paul DL, Goodenough DA. Connexin family of gap junction proteins. J Membr Biol. 1990 Jul; 116(3):187-94. PMID: 2167375.
    Citations: 102     Fields:    Translation:AnimalsCells
  95. Musil LS, Beyer EC, Goodenough DA. Expression of the gap junction protein connexin43 in embryonic chick lens: molecular cloning, ultrastructural localization, and post-translational phosphorylation. J Membr Biol. 1990 Jun; 116(2):163-75. PMID: 2166164.
    Citations: 83     Fields:    Translation:AnimalsCells
  96. Tibbitts TT, Caspar DL, Phillips WC, Goodenough DA. Diffraction diagnosis of protein folding in gap junction connexons. Biophys J. 1990 May; 57(5):1025-36. PMID: 2160297.
    Citations: 11     Fields:    Translation:AnimalsCells
  97. Goodenough, D.A. . Gap junctions and intercellular communication. in Morphoregulatory Molecules. G.M. Edelman, B.A. Cunningham, and J.-P. Thiery, eds. 1990; 357-369.
  98. Beyer, E.C., D.L. Paul, and D.A. Goodenough . Connexin family of gap junction proteins. J. Membrane Biol. 1990; 116:187-194.
  99. Ebihara L, Beyer EC, Swenson KI, Paul DL, Goodenough DA. Cloning and expression of a Xenopus embryonic gap junction protein. Science. 1989 Mar 03; 243(4895):1194-5. PMID: 2466337.
    Citations: 53     Fields:    Translation:AnimalsCells
  100. Beyer EC, Kistler J, Paul DL, Goodenough DA. Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues. J Cell Biol. 1989 Feb; 108(2):595-605. PMID: 2537319.
    Citations: 105     Fields:    Translation:AnimalsCells
  101. Siliciano JD, Goodenough DA. Localization of the tight junction protein, ZO-1, is modulated by extracellular calcium and cell-cell contact in Madin-Darby canine kidney epithelial cells. J Cell Biol. 1988 Dec; 107(6 Pt 1):2389-99. PMID: 3058722.
    Citations: 44     Fields:    Translation:Cells
  102. Stevenson BR, Anderson JM, Goodenough DA, Mooseker MS. Tight junction structure and ZO-1 content are identical in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance. J Cell Biol. 1988 Dec; 107(6 Pt 1):2401-8. PMID: 3058723.
    Citations: 61     Fields:    Translation:AnimalsCells
  103. Goodenough DA, Paul DL, Jesaitis L. Topological distribution of two connexin32 antigenic sites in intact and split rodent hepatocyte gap junctions. J Cell Biol. 1988 Nov; 107(5):1817-24. PMID: 2460469.
    Citations: 57     Fields:    Translation:AnimalsCells
  104. Sosinsky GE, Jésior JC, Caspar DL, Goodenough DA. Gap junction structures. VIII. Membrane cross-sections. Biophys J. 1988 May; 53(5):709-22. PMID: 2455550.
    Citations: 10     Fields:    Translation:AnimalsCells
  105. Anderson JM, Stevenson BR, Jesaitis LA, Goodenough DA, Mooseker MS. Characterization of ZO-1, a protein component of the tight junction from mouse liver and Madin-Darby canine kidney cells. J Cell Biol. 1988 Apr; 106(4):1141-9. PMID: 2452168.
    Citations: 94     Fields:    Translation:AnimalsCells
  106. Beyer, E.C., D.A. Goodenough, and D.L. Paul. The connexins, a family of related gap junction proteins. in Gap Junctions. E.L. Hertzberg and R. Johnson, eds. 1988; 167-175.
  107. Caspar, D.L.D., G.E.Sosinsky, T.T. Tibbitts, W.C. Phillips, and D.A. Goodenough. Gap junction structure. in Gap Junctions. E.L. Hertzberg and R. Johnson, eds. 1988; 177-133.
  108. Beyer EC, Paul DL, Goodenough DA. Connexin43: a protein from rat heart homologous to a gap junction protein from liver. J Cell Biol. 1987 Dec; 105(6 Pt 1):2621-9. PMID: 2826492.
    Citations: 239     Fields:    Translation:AnimalsCells
  109. Gruijters WT, Kistler J, Bullivant S, Goodenough DA. Immunolocalization of MP70 in lens fiber 16-17-nm intercellular junctions. J Cell Biol. 1987 Mar; 104(3):565-72. PMID: 3818793.
    Citations: 30     Fields:    Translation:AnimalsCells
  110. Stevenson BR, Siliciano JD, Mooseker MS, Goodenough DA. Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J Cell Biol. 1986 Sep; 103(3):755-66. PMID: 3528172.
    Citations: 359     Fields:    Translation:AnimalsCells
  111. FitzGerald PG, Goodenough DA. Rat lens cultures: MIP expression and domains of intercellular coupling. Invest Ophthalmol Vis Sci. 1986 May; 27(5):755-71. PMID: 3700025.
    Citations: 9     Fields:    Translation:AnimalsCells
  112. Miller TM, Goodenough DA. Evidence for two physiologically distinct gap junctions expressed by the chick lens epithelial cell. J Cell Biol. 1986 Jan; 102(1):194-9. PMID: 3079768.
    Citations: 24     Fields:    Translation:AnimalsCells
  113. Miller TM, Goodenough DA. Gap junction structures after experimental alteration of junctional channel conductance. J Cell Biol. 1985 Nov; 101(5 Pt 1):1741-8. PMID: 2414303.
    Citations: 13     Fields:    Translation:AnimalsCells
  114. Baker TS, Sosinsky GE, Caspar DL, Gall C, Goodenough DA. Gap junction structures. VII. Analysis of connexon images obtained with cationic and anionic negative stains. J Mol Biol. 1985 Jul 05; 184(1):81-98. PMID: 2411939.
    Citations: 9     Fields:    Translation:AnimalsCells
  115. Makowski L, Caspar DL, Phillips WC, Goodenough DA. Gap junction structures. V. Structural chemistry inferred from X-ray diffraction measurements on sucrose accessibility and trypsin susceptibility. J Mol Biol. 1984 Apr 15; 174(3):449-81. PMID: 6716484.
    Citations: 16     Fields:    Translation:AnimalsCells
  116. Stevenson BR, Goodenough DA. Zonulae occludentes in junctional complex-enriched fractions from mouse liver: preliminary morphological and biochemical characterization. J Cell Biol. 1984 Apr; 98(4):1209-21. PMID: 6425301.
    Citations: 44     Fields:    Translation:AnimalsCells
  117. Makowski L, Caspar DL, Phillips WC, Baker TS, Goodenough DA. Gap junction structures. VI. Variation and conservation in connexon conformation and packing. Biophys J. 1984 Jan; 45(1):208-18. PMID: 6324904.
    Citations: 16     Fields:    Translation:AnimalsCells
  118. Paul DL, Goodenough DA. Preparation, characterization, and localization of antisera against bovine MP26, an integral protein from lens fiber plasma membrane. J Cell Biol. 1983 Mar; 96(3):625-32. PMID: 6339520.
    Citations: 39     Fields:    Translation:AnimalsCells
  119. Paul DL, Goodenough DA. In vitro synthesis and membrane insertion of bovine MP26, an integral protein from lens fiber plasma membrane. J Cell Biol. 1983 Mar; 96(3):633-8. PMID: 6833374.
    Citations: 9     Fields:    Translation:AnimalsCells
  120. Baker TS, Caspar DL, Hollingshead CJ, Goodenough DA. Gap junction structures. IV. Asymmetric features revealed by low-irradiation microscopy. J Cell Biol. 1983 Jan; 96(1):204-16. PMID: 6186671.
    Citations: 23     Fields:    Translation:AnimalsCells
  121. Schuetze SM, Goodenough DA. Dye transfer between cells of the embryonic chick lens becomes less sensitive to CO2 treatment with development. J Cell Biol. 1982 Mar; 92(3):694-705. PMID: 6806303.
    Citations: 29     Fields:    Translation:AnimalsCells
  122. St John PA, Froehner SC, Goodenough DA, Cohen JB. Nicotinic postsynaptic membranes from Torpedo: sidedness, permeability to macromolecules, and topography of major polypeptides. J Cell Biol. 1982 Feb; 92(2):333-42. PMID: 6174528.
    Citations: 22     Fields:    Translation:AnimalsCells
  123. Makowski L, Caspar DL, Goodenough DA, Phillips WC. Gap Junction Structures: III. The Effect of Variations in the Isolation Procedure. Biophys J. 1982 Jan; 37(1):189-91. PMID: 19431471.
    Citations: 16     Fields:    
  124. Fallon RF, Goodenough DA. Five-hour half-life of mouse liver gap-junction protein. J Cell Biol. 1981 Aug; 90(2):521-6. PMID: 7287816.
    Citations: 94     Fields:    Translation:AnimalsCells
  125. Raviola E, Goodenough DA, Raviola G. Structure of rapidly frozen gap junctions. J Cell Biol. 1980 Oct; 87(1):273-9. PMID: 7419595.
    Citations: 39     Fields:    Translation:AnimalsCells
  126. Kensler RW, Goodenough DA. Isolation of mouse myocardial gap junctions. J Cell Biol. 1980 Sep; 86(3):755-64. PMID: 7410477.
    Citations: 19     Fields:    Translation:AnimalsCells
  127. Goodenough DA, Dick JS, Lyons JE. Lens metabolic cooperation: a study of mouse lens transport and permeability visualized with freeze-substitution autoradiography and electron microscopy. J Cell Biol. 1980 Aug; 86(2):576-89. PMID: 6772650.
    Citations: 48     Fields:    Translation:Animals
  128. Goodenough DA. Intercellular junctions. Soc Gen Physiol Ser. 1980; 34:167-78. PMID: 6992281.
    Citations: 1     Fields:    Translation:AnimalsCells
  129. Goodenough, D.A. Intercellular junctions. in The Role of Intercellular Signals: Navigation, Encounter, Outcome, ed. J.G. Nichols Berlin: Dahlem Konferenzen. 1980; 135-154.
  130. Goodenough DA. Lens gap junctions: a structural hypothesis for nonregulated low-resistance intercellular pathways. Invest Ophthalmol Vis Sci. 1979 Nov; 18(11):1104-22. PMID: 511455.
    Citations: 56     Fields:    Translation:Animals
  131. Kirschner DA, Hollingshead CJ, Thaxton C, Caspar DL, Goodenough DA. Structural states of myelin observed by x-ray diffraction and freeze-fracture electron microscopy. J Cell Biol. 1979 Jul; 82(1):140-9. PMID: 479295.
    Citations: 7     Fields:    Translation:AnimalsCells
  132. Goodenough,D.A. Gap junction dynamics and intercellular communication. Pharm. Rev. 1979; 30:383-392.
  133. Goodenough, D.A. and N.B. Gilula. Functional membrane differentiations at sites of cell-cell interaction. in The Role of Intercellular Signals: Navigation, Encounter, Outcome, Berlin: Dahlem Konferenzen ed. J.G. Nichols. 1979; 135-154.
  134. Goodenough DA. Gap junction dynamics and intercellular communication. Pharmacol Rev. 1978 Dec; 30(4):383-92. PMID: 392536.
    Citations: 4     Fields:    Translation:AnimalsCells
  135. Forest CL, Goodenough DA, Goodenough UW. Flagellar membrane agglutination and sexual signaling in the conditional GAM-1 mutant of Chlamydomonas. J Cell Biol. 1978 Oct; 79(1):74-84. PMID: 701379.
    Citations: 13     Fields:    Translation:AnimalsCells
  136. Bennett MV, Goodenough DA. Gap junctions, electrotonic coupling, and intercellular communication. Neurosci Res Program Bull. 1978 Sep; 16(3):1-486. PMID: 216953.
    Citations: 81     Fields:    Translation:AnimalsCells
  137. Goodenough, D.A., D.L. Paul, and K.E. Culbert . Correlative gap junction ultrastructure. The Molecular Basis of Cell-Cell Interaction, R.A. Lerner and D. Bergsma, eds., Birth Defects: Original Article Series, Volume XIV, Number 2. 1978; 83-97.
  138. Goodenough DA, Paul DL, Culbert KE. Correlative gap junction ultrastructure. Birth Defects Orig Artic Ser. 1978; 14(2):83-97. PMID: 346085.
    Citations: 4     Fields:    Translation:AnimalsCells
  139. Caspar DL, Goodenough DA, Makowski L, Phillips WC. Gap junction structures. I. Correlated electron microscopy and x-ray diffraction. J Cell Biol. 1977 Aug; 74(2):605-28. PMID: 885916.
    Citations: 88     Fields:    Translation:AnimalsCells
  140. Makowski L, Caspar DL, Phillips WC, Goodenough DA. Gap junction structures. II. Analysis of the x-ray diffraction data. J Cell Biol. 1977 Aug; 74(2):629-45. PMID: 889612.
    Citations: 129     Fields:    Translation:AnimalsCells
  141. Weiss RL, Goodenough DA, Goodenough UW. Membrane particle arrays associated with the basal body and with contractile vacuole secretion in Chlamydomonas. J Cell Biol. 1977 Jan; 72(1):133-43. PMID: 830652.
    Citations: 26     Fields:    Translation:AnimalsCells
  142. Weiss RL, Goodenough DA, Goodenough UW. Membrane differentiations at sites specialized for cell fusion. J Cell Biol. 1977 Jan; 72(1):144-60. PMID: 830653.
    Citations: 18     Fields:    Translation:AnimalsCells
  143. Nadol JB, Mulroy MJ, Goodenough DA, Weiss TF. Tight and gap junctions in a vertebrate inner ear. Am J Anat. 1976 Nov; 147(3):281-301. PMID: 983970.
    Citations: 15     Fields:    Translation:AnimalsCells
  144. Goodenough DA. In vitro formation of gap junction vesicles. J Cell Biol. 1976 Feb; 68(2):220-31. PMID: 54358.
    Citations: 28     Fields:    Translation:AnimalsCells
  145. Goodenough DA. The structure and permeability of isolated hepatocyte gap junctions. Cold Spring Harb Symp Quant Biol. 1976; 40:37-43. PMID: 181200.
    Citations: 10     Fields:    Translation:AnimalsCells
  146. Bergman K, Goodenough UW, Goodenough DA, Jawitz J, Martin H. Gametic differentiation in Chlamydomonas reinhardtii. II. Flagellar membranes and the agglutination reaction. J Cell Biol. 1975 Dec; 67(3):606-22. PMID: 1202016.
    Citations: 47     Fields:    Translation:AnimalsCells
  147. Goodenough DA. The structure of cell membranes involved in intercellular communication. Am J Clin Pathol. 1975 May; 63(5):636-45. PMID: 1130322.
    Citations: 5     Fields:    Translation:AnimalsCells
  148. Goodenough,D.A. Methods for the isolation and structural characterization of hepatocyte gap junctions. in Methods in Membrane Biology, E.D. Korn, ed. 1975; 51-80.
  149. Goodenough DA, Gilula NB. The splitting of hepatocyte gap junctions and zonulae occludentes with hypertonic disaccharides. J Cell Biol. 1974 Jun; 61(3):575-90. PMID: 4836384.
    Citations: 45     Fields:    Translation:AnimalsCells
  150. Goodenough DA. Bulk isolation of mouse hepatocyte gap junctions. Characterization of the principal protein, connexin. J Cell Biol. 1974 May; 61(2):557-63. PMID: 4363961.
    Citations: 44     Fields:    Translation:AnimalsCells
  151. Harrison SC, Jack A, Goodenough D, Sefton BM. Structural studies of spherical viruses. J Supramol Struct. 1974; 2(2-4):486-95. PMID: 4437182.
    Citations: 8     Fields:    Translation:Cells
  152. Claude P, Goodenough DA. Fracture faces of zonulae occludentes from "tight" and "leaky" epithelia. J Cell Biol. 1973 Aug; 58(2):390-400. PMID: 4199658.
    Citations: 266     Fields:    Translation:AnimalsCells
  153. Goodenough DA, Stoeckenius W. The isolation of mouse hepatocyte gap junctions. Preliminary chemical characterization and x-ray diffraction. J Cell Biol. 1972 Sep; 54(3):646-56. PMID: 4339819.
    Citations: 55     Fields:    Translation:AnimalsCells
  154. Goodenough, D.A. and N.B. Gilula. Cell junctions and intercellular communication. in Membranes and Viruses in Immunopathology. S.B. Day and R.A. Good, eds. 1972; 155-168.
  155. Goodenough DA, Revel JP. The permeability of isolated and in situ mouse hepatic gap junctions studied with enzymatic tracers. J Cell Biol. 1971 Jul; 50(1):81-91. PMID: 5563453.
    Citations: 17     Fields:    Translation:AnimalsCells
  156. Daniel Goodenough. The Ultrastructure and Biochemistry of Hepatic Intercellular Junctions. 1970.
  157. Goodenough DA, Revel JP. A fine structural analysis of intercellular junctions in the mouse liver. J Cell Biol. 1970 May; 45(2):272-90. PMID: 4105112.
    Citations: 199     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.