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Jing Xuan Kang, Ph.D., M.D.


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  1. R01CA113605 (KANG, JING X) Jul 1, 2006 - May 31, 2010
    Omega-6/Omega-3 Fatty Acid Ratio and Tumorigenesis
    Role: Principal Investigator
  2. R01CA079553 (KANG, JING X) Jan 1, 1999 - Dec 31, 2003
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Chen CY, Su CW, Li X, Liu Y, Pan Q, Cao T, Kang JX. Lipid Extract From a Vegetable (Sonchus Oleraceus) Attenuates Adipogenesis and High Fat Diet-Induced Obesity Associated With AMPK Activation. Front Nutr. 2021; 8:624283. PMID: 33889593.
  2. Chen CY, Su CW, Kang JX. Endogenous Omega-3 Polyunsaturated Fatty Acids Reduce the Number and Differentiation of White Adipocyte Progenitors in Mice. Obesity (Silver Spring). 2020 02; 28(2):235-240. PMID: 31721479.
    Citations: 2     Fields:    Translation:AnimalsCells
  3. Kaliannan K, Li XY, Wang B, Pan Q, Chen CY, Hao L, Xie S, Kang JX. Multi-omic analysis in transgenic mice implicates omega-6/omega-3 fatty acid imbalance as a risk factor for chronic disease. Commun Biol. 2019 Jul 26; 2(1):276. PMID: 31925118.
  4. Kaliannan K, Li XY, Wang B, Pan Q, Chen CY, Hao L, Xie S, Kang JX. Multi-omic analysis in transgenic mice implicates omega-6/omega-3 fatty acid imbalance as a risk factor for chronic disease. Commun Biol. 2019; 2:276. PMID: 31372515.
    Citations: 11     Translation:Animals
  5. Li J, Chen CY, Arita M, Kim K, Li X, Zhang H, Kang JX. An omega-3 polyunsaturated fatty acid derivative, 18-HEPE, protects against CXCR4-associated melanoma metastasis. Carcinogenesis. 2018 12 13; 39(11):1380-1388. PMID: 30184109.
    Citations: 4     Fields:    Translation:AnimalsCells
  6. Kaliannan K, Robertson RC, Murphy K, Stanton C, Kang C, Wang B, Hao L, Bhan AK, Kang JX. Estrogen-mediated gut microbiome alterations influence sexual dimorphism in metabolic syndrome in mice. Microbiome. 2018 11 13; 6(1):205. PMID: 30424806.
    Citations: 27     Fields:    Translation:AnimalsCells
  7. Wang B, Smyl C, Chen CY, Li XY, Huang W, Zhang HM, Pai VJ, Kang JX. Suppression of Postprandial Blood Glucose Fluctuations by a Low-Carbohydrate, High-Protein, and High-Omega-3 Diet via Inhibition of Gluconeogenesis. Int J Mol Sci. 2018 Jun 21; 19(7). PMID: 29933567.
    Citations: 4     Fields:    Translation:AnimalsCells
  8. Robertson RC, Kaliannan K, Strain CR, Ross RP, Stanton C, Kang JX. Maternal omega-3 fatty acids regulate offspring obesity through persistent modulation of gut microbiota. Microbiome. 2018 05 24; 6(1):95. PMID: 29793531.
    Citations: 18     Fields:    Translation:AnimalsCells
  9. Li XY, Liu YH, Wang B, Chen CY, Zhang HM, Kang JX. Identification of a sustainable two-plant diet that effectively prevents age-related metabolic syndrome and extends lifespan in aged mice. J Nutr Biochem. 2018 01; 51:16-26. PMID: 29080417.
    Citations: 3     Fields:    Translation:Animals
  10. Wang M, Han J, Marcar L, Black J, Liu Q, Li X, Nagulapalli K, Sequist LV, Mak RH, Benes CH, Hong TS, Gurtner K, Krause M, Baumann M, Kang JX, Whetstine JR, Willers H. Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin-EGFR Pathway. Cancer Res. 2017 04 15; 77(8):2018-2028. PMID: 28202526.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  11. Li XY, Hao L, Liu YH, Chen CY, Pai VJ, Kang JX. Protection against fine particle-induced pulmonary and systemic inflammation by omega-3 polyunsaturated fatty acids. Biochim Biophys Acta Gen Subj. 2017 Mar; 1861(3):577-584. PMID: 28011301.
    Citations: 14     Fields:    Translation:AnimalsPHPublic Health
  12. Huang W, Wang B, Li X, Kang JX. Endogenously elevated n-3 polyunsaturated fatty acids alleviate acute ethanol-induced liver steatosis. Biofactors. 2015 Nov-Dec; 41(6):453-62. PMID: 26637972.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  13. Kaliannan K, Wang B, Li XY, Kim KJ, Kang JX. A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia. Sci Rep. 2015 Jun 11; 5:11276. PMID: 26062993.
    Citations: 75     Fields:    Translation:Animals
  14. Brigandi SA, Shao H, Qian SY, Shen Y, Wu BL, Kang JX. Autistic children exhibit decreased levels of essential Fatty acids in red blood cells. Int J Mol Sci. 2015 May 04; 16(5):10061-76. PMID: 25946342.
    Citations: 23     Fields:    Translation:HumansCells
  15. Li X, Ballantyne LL, Che X, Mewburn JD, Kang JX, Barkley RM, Murphy RC, Yu Y, Funk CD. Endogenously generated omega-3 fatty acids attenuate vascular inflammation and neointimal hyperplasia by interaction with free fatty acid receptor 4 in mice. J Am Heart Assoc. 2015 Apr 06; 4(4). PMID: 25845931.
    Citations: 20     Fields:    Translation:Animals
  16. Belchior T, Paschoal VA, Magdalon J, Chimin P, Farias TM, Chaves-Filho AB, Gorjão R, St-Pierre P, Miyamoto S, Kang JX, Deshaies Y, Marette A, Festuccia W. Omega-3 fatty acids protect from diet-induced obesity, glucose intolerance, and adipose tissue inflammation through PPAR?-dependent and PPAR?-independent actions. Mol Nutr Food Res. 2015 May; 59(5):957-67. PMID: 25641959.
    Citations: 15     Fields:    Translation:Animals
  17. Kang JX. Nutritional problems and solutions for the modern health epidemic. J Nutrigenet Nutrigenomics. 2014; 7(4-6):188-90. PMID: 25766253.
    Citations: 1     Fields:    Translation:Humans
  18. Liu YH, Li XY, Chen CY, Zhang HM, Kang JX. Omega-3 fatty acid intervention suppresses lipopolysaccharide-induced inflammation and weight loss in mice. Mar Drugs. 2015 Feb 13; 13(2):1026-36. PMID: 25689565.
    Citations: 3     Fields:    Translation:Animals
  19. White PJ, Mitchell PL, Schwab M, Trottier J, Kang JX, Barbier O, Marette A. Transgenic ?-3 PUFA enrichment alters morphology and gene expression profile in adipose tissue of obese mice: Potential role for protectins. Metabolism. 2015 Jun; 64(6):666-76. PMID: 25726444.
    Citations: 12     Fields:    Translation:AnimalsCells
  20. Endo J, Sano M, Isobe Y, Fukuda K, Kang JX, Arai H, Arita M. 18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload-induced maladaptive cardiac remodeling. J Exp Med. 2014 Jul 28; 211(8):1673-87. PMID: 25049337.
    Citations: 34     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  21. Li J, Li FR, Wei D, Jia W, Kang JX, Stefanovic-Racic M, Dai Y, Zhao AZ. Endogenous ?-3 polyunsaturated fatty acid production confers resistance to obesity, dyslipidemia, and diabetes in mice. Mol Endocrinol. 2014 Aug; 28(8):1316-28. PMID: 24978197.
    Citations: 17     Fields:    Translation:AnimalsCells
  22. Pang SC, Wang HP, Li KY, Zhu ZY, Kang JX, Sun YH. Double transgenesis of humanized fat1 and fat2 genes promotes omega-3 polyunsaturated fatty acids synthesis in a zebrafish model. Mar Biotechnol (NY). 2014 Oct; 16(5):580-93. PMID: 24832481.
    Citations: 2     Fields:    Translation:HumansAnimals
  23. Pai VJ, Wang B, Li X, Wu L, Kang JX. Transgenic mice convert carbohydrates to essential fatty acids. PLoS One. 2014; 9(5):e97637. PMID: 24836606.
    Citations: 2     Fields:    Translation:AnimalsCells
  24. Kang JX, Wan JB, He C. Concise review: Regulation of stem cell proliferation and differentiation by essential fatty acids and their metabolites. Stem Cells. 2014 May; 32(5):1092-8. PMID: 24356924.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  25. Astarita G, McKenzie JH, Wang B, Strassburg K, Doneanu A, Johnson J, Baker A, Hankemeier T, Murphy J, Vreeken RJ, Langridge J, Kang JX. A protective lipidomic biosignature associated with a balanced omega-6/omega-3 ratio in fat-1 transgenic mice. PLoS One. 2014; 9(4):e96221. PMID: 24760204.
    Citations: 9     Fields:    Translation:AnimalsCells
  26. Kang JX. Frontiers of nutritional intervention. J Nutrigenet Nutrigenomics. 2013; 6(6):I-II. PMID: 24713680.
    Citations:    Fields:    Translation:Humans
  27. Taguchi A, Kawana K, Tomio K, Yamashita A, Isobe Y, Nagasaka K, Koga K, Inoue T, Nishida H, Kojima S, Adachi K, Matsumoto Y, Arimoto T, Wada-Hiraike O, Oda K, Kang JX, Arai H, Arita M, Osuga Y, Fujii T. Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyunsaturated fatty acids in vitro and in vivo. PLoS One. 2014; 9(2):e89605. PMID: 24586907.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  28. Kang JX. Future directions in nutrition research. J Nutrigenet Nutrigenomics. 2013; 6(4-5):I-III. PMID: 24434908.
    Citations:    Fields:    Translation:Humans
  29. Zhou L, Wang L, Kang JX, Xie W, Li X, Wu C, Xu B, Wu J. Production of fat-1 transgenic rats using a post-natal female germline stem cell line. Mol Hum Reprod. 2014 Mar; 20(3):271-81. PMID: 24258451.
    Citations: 36     Fields:    Translation:AnimalsCells
  30. Romanatto T, Fiamoncini J, Wang B, Curi R, Kang JX. Elevated tissue omega-3 fatty acid status prevents age-related glucose intolerance in fat-1 transgenic mice. Biochim Biophys Acta. 2014 Feb; 1842(2):186-91. PMID: 24211484.
    Citations: 15     Fields:    Translation:AnimalsCells
  31. Yamashita A, Kawana K, Tomio K, Taguchi A, Isobe Y, Iwamoto R, Masuda K, Furuya H, Nagamatsu T, Nagasaka K, Arimoto T, Oda K, Wada-Hiraike O, Yamashita T, Taketani Y, Kang JX, Kozuma S, Arai H, Arita M, Osuga Y, Fujii T. Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth. Sci Rep. 2013 Nov 01; 3:3113. PMID: 24177907.
    Citations: 14     Fields:    Translation:AnimalsCells
  32. Kang JX. Nutrigenomics and cancer therapy. J Nutrigenet Nutrigenomics. 2013; 6(3):I-II. PMID: 24081310.
    Citations:    Fields:    Translation:Humans
  33. Zou Z, Bellenger S, Massey KA, Nicolaou A, Geissler A, Bidu C, Bonnotte B, Pierre AS, Minville-Walz M, Rialland M, Seubert J, Kang JX, Lagrost L, Narce M, Bellenger J. Inhibition of the HER2 pathway by n-3 polyunsaturated fatty acids prevents breast cancer in fat-1 transgenic mice. J Lipid Res. 2013 Dec; 54(12):3453-63. PMID: 24052576.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  34. Tomio K, Kawana K, Taguchi A, Isobe Y, Iwamoto R, Yamashita A, Kojima S, Mori M, Nagamatsu T, Arimoto T, Oda K, Osuga Y, Taketani Y, Kang JX, Arai H, Arita M, Kozuma S, Fujii T. Omega-3 polyunsaturated Fatty acids suppress the cystic lesion formation of peritoneal endometriosis in transgenic mouse models. PLoS One. 2013; 8(9):e73085. PMID: 24039864.
    Citations: 14     Fields:    Translation:AnimalsCells
  35. Orr SK, Palumbo S, Bosetti F, Mount HT, Kang JX, Greenwood CE, Ma DW, Serhan CN, Bazinet RP. Unesterified docosahexaenoic acid is protective in neuroinflammation. J Neurochem. 2013 Nov; 127(3):378-93. PMID: 23919613.
    Citations: 55     Fields:    Translation:Animals
  36. Kang JX. Gut microbiota and personalized nutrition. J Nutrigenet Nutrigenomics. 2013; 6(2):I-II. PMID: 23774142.
    Citations: 3     Fields:    Translation:Humans
  37. Kang JX, Liu A. The role of the tissue omega-6/omega-3 fatty acid ratio in regulating tumor angiogenesis. Cancer Metastasis Rev. 2013 Jun; 32(1-2):201-10. PMID: 23090260.
    Citations: 17     Fields:    Translation:HumansAnimals
  38. Kang JX, Gleason ED. Omega-3 Fatty acids and hippocampal neurogenesis in depression. CNS Neurol Disord Drug Targets. 2013 Jun; 12(4):460-5. PMID: 23574158.
    Citations: 10     Fields:    Translation:HumansAnimals
  39. Zhang LT, Zhang LJ, Zhang JJ, Ye XX, Xie AM, Chen LY, Kang JX, Cai C. Quantification of the sixth DNA base 5-hydroxymethylcytosine in colorectal cancer tissue and C-26 cell line. Bioanalysis. 2013 Apr; 5(7):839-45. PMID: 23534428.
    Citations: 9     Fields:    Translation:HumansCells
  40. Pender-Cudlip MC, Krag KJ, Martini D, Yu J, Guidi A, Skinner SS, Zhang Y, Qu X, He C, Xu Y, Qian SY, Kang JX. Delta-6-desaturase activity and arachidonic acid synthesis are increased in human breast cancer tissue. Cancer Sci. 2013 Jun; 104(6):760-4. PMID: 23414387.
    Citations: 21     Fields:    Translation:Humans
  41. López-Vicario C, González-Périz A, Rius B, Morán-Salvador E, García-Alonso V, Lozano JJ, Bataller R, Cofán M, Kang JX, Arroyo V, Clària J, Titos E. Molecular interplay between ?5/?6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis. Gut. 2014 Feb; 63(2):344-55. PMID: 23492103.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  42. Huang LL, Wan JB, Wang B, He CW, Ma H, Li TW, Kang JX. Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines. Prostaglandins Leukot Essent Fatty Acids. 2013 May; 88(5):347-53. PMID: 23474173.
    Citations: 23     Fields:    Translation:AnimalsCells
  43. Zhang J, Zhang L, Ye X, Chen L, Zhang L, Gao Y, Kang JX, Cai C. Characteristics of fatty acid distribution is associated with colorectal cancer prognosis. Prostaglandins Leukot Essent Fatty Acids. 2013 May; 88(5):355-60. PMID: 23465412.
    Citations: 15     Fields:    Translation:Humans
  44. Kang JX. Dr. Alexander Leaf, an exemplary physician-scientist and a great man: a true leader in the study of fatty acids and lipids. Prostaglandins Leukot Essent Fatty Acids. 2013 Mar; 88(3):197-9. PMID: 23615572.
    Citations:    Fields:    
  45. Kang JX. Nutrigenomics and systems biology. J Nutrigenet Nutrigenomics. 2012; 5(6):I-II. PMID: 23406947.
    Citations:    Fields:    Translation:Humans
  46. Lim SN, Gladman SJ, Dyall SC, Patel U, Virani N, Kang JX, Priestley JV, Michael-Titus AT. Transgenic mice with high endogenous omega-3 fatty acids are protected from spinal cord injury. Neurobiol Dis. 2013 Mar; 51:104-12. PMID: 23123586.
    Citations: 18     Fields:    Translation:Animals
  47. Kang JX. Reduction of heart rate by omega-3 fatty acids and the potential underlying mechanisms. Front Physiol. 2012; 3:416. PMID: 23115552.
    Citations: 12     
  48. He C, Qu X, Wan J, Rong R, Huang L, Cai C, Zhou K, Gu Y, Qian SY, Kang JX. Inhibiting delta-6 desaturase activity suppresses tumor growth in mice. PLoS One. 2012; 7(10):e47567. PMID: 23112819.
    Citations: 15     Fields:    Translation:AnimalsCells
  49. MacLennan MB, Clarke SE, Perez K, Wood GA, Muller WJ, Kang JX, Ma DW. Mammary tumor development is directly inhibited by lifelong n-3 polyunsaturated fatty acids. J Nutr Biochem. 2013 Jan; 24(1):388-95. PMID: 23026490.
    Citations: 21     Fields:    Translation:Animals
  50. Kang JX. Identification of metabolic biomarkers for personalized nutrition. J Nutrigenet Nutrigenomics. 2012; 5(2):I-II. PMID: 22965161.
    Citations: 2     Fields:    Translation:Humans
  51. Kang JX. The coming of age of nutrigenetics and nutrigenomics. J Nutrigenet Nutrigenomics. 2012; 5(1):I-II. PMID: 22699841.
    Citations: 4     Fields:    Translation:Humans
  52. Zhang L, Zhang L, Zhou K, Ye X, Zhang J, Xie A, Chen L, Kang JX, Cai C. Simultaneous determination of global DNA methylation and hydroxymethylation levels by hydrophilic interaction liquid chromatography-tandem mass spectrometry. J Biomol Screen. 2012 Aug; 17(7):877-84. PMID: 22644266.
    Citations: 3     Fields:    Translation:AnimalsCells
  53. He C, Rong R, Liu J, Wan J, Zhou K, Kang JX. Effects of Coptis extract combined with chemotherapeutic agents on ROS production, multidrug resistance, and cell growth in A549 human lung cancer cells. Chin Med. 2012 Apr 30; 7(1):11. PMID: 22546215.
    Citations: 10     
  54. Algamas-Dimantov A, Davidovsky D, Ben-Ari J, Kang JX, Peri I, Hertz R, Bar-Tana J, Schwartz B. Amelioration of diabesity-induced colorectal ontogenesis by omega-3 fatty acids in mice. J Lipid Res. 2012 Jun; 53(6):1056-70. PMID: 22357704.
    Citations: 6     Fields:    Translation:AnimalsCells
  55. Jiao J, Kang JX, Tan R, Wang J, Zhang Y. Multiplex time-reducing quantitative polymerase chain reaction assay for determination of telomere length in blood and tissue DNA. Anal Bioanal Chem. 2012 Apr; 403(1):157-66. PMID: 22327932.
    Citations: 2     Fields:    Translation:AnimalsCells
  56. Gladman SJ, Huang W, Lim SN, Dyall SC, Boddy S, Kang JX, Knight MM, Priestley JV, Michael-Titus AT. Improved outcome after peripheral nerve injury in mice with increased levels of endogenous ?-3 polyunsaturated fatty acids. J Neurosci. 2012 Jan 11; 32(2):563-71. PMID: 22238091.
    Citations: 25     Fields:    Translation:AnimalsCells
  57. Song KS, Jing K, Kim JS, Yun EJ, Shin S, Seo KS, Park JH, Heo JY, Kang JX, Suh KS, Wu T, Park JI, Kweon GR, Yoon WH, Hwang BD, Lim K. Omega-3-polyunsaturated fatty acids suppress pancreatic cancer cell growth in vitro and in vivo via downregulation of Wnt/Beta-catenin signaling. Pancreatology. 2011; 11(6):574-84. PMID: 22213040.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  58. Kang JX. The omega-6/omega-3 fatty acid ratio in chronic diseases: animal models and molecular aspects. World Rev Nutr Diet. 2011; 102:22-29. PMID: 21865816.
    Citations: 12     Fields:    Translation:Animals
  59. Purwaha P, Gu Y, Kelavkar U, Kang JX, Law B, Wu E, Qian SY. LC/ESR/MS study of pH-dependent radical generation from 15-LOX-catalyzed DPA peroxidation. Free Radic Biol Med. 2011 Oct 01; 51(7):1461-70. PMID: 21807091.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  60. Bilal S, Haworth O, Wu L, Weylandt KH, Levy BD, Kang JX. Fat-1 transgenic mice with elevated omega-3 fatty acids are protected from allergic airway responses. Biochim Biophys Acta. 2011 Sep; 1812(9):1164-9. PMID: 21616147.
    Citations: 37     Fields:    Translation:Animals
  61. Kang JX. Omega-3: a link between global climate change and human health. Biotechnol Adv. 2011 Jul-Aug; 29(4):388-90. PMID: 21406222.
    Citations: 11     Fields:    Translation:Humans
  62. Weylandt KH, Krause LF, Gomolka B, Chiu CY, Bilal S, Nadolny A, Waechter SF, Fischer A, Rothe M, Kang JX. Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-a. Carcinogenesis. 2011 Jun; 32(6):897-903. PMID: 21421544.
    Citations: 47     Fields:    Translation:AnimalsCells
  63. Bellenger J, Bellenger S, Bataille A, Massey KA, Nicolaou A, Rialland M, Tessier C, Kang JX, Narce M. High pancreatic n-3 fatty acids prevent STZ-induced diabetes in fat-1 mice: inflammatory pathway inhibition. Diabetes. 2011 Apr; 60(4):1090-9. PMID: 21330635.
    Citations: 44     Fields:    Translation:AnimalsCells
  64. Lebbadi M, Julien C, Phivilay A, Tremblay C, Emond V, Kang JX, Calon F. Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease. J Alzheimers Dis. 2011; 27(4):853-69. PMID: 21914946.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  65. Bousquet M, Gue K, Emond V, Julien P, Kang JX, Cicchetti F, Calon F. Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease. J Lipid Res. 2011 Feb; 52(2):263-71. PMID: 21115966.
    Citations: 22     Fields:    Translation:Animals
  66. Kang JX. Effect of ?-3 fatty acids on life span. Nutrition. 2011 Mar; 27(3):333. PMID: 20934849.
    Citations:    Fields:    Translation:AnimalsCells
  67. Smith BK, Holloway GP, Reza-Lopez S, Jeram SM, Kang JX, Ma DW. A decreased n-6/n-3 ratio in the fat-1 mouse is associated with improved glucose tolerance. Appl Physiol Nutr Metab. 2010 Oct; 35(5):699-706. PMID: 20962926.
    Citations: 15     Fields:    Translation:AnimalsCells
  68. Kang JX. Differential effects of omega-6 and omega-3 fatty acids on telomere length. Am J Clin Nutr. 2010 Nov; 92(5):1276-7; author reply 1277. PMID: 20844067.
    Citations: 2     Fields:    Translation:HumansCells
  69. White PJ, Arita M, Taguchi R, Kang JX, Marette A. Transgenic restoration of long-chain n-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high-fat-fed mice. Diabetes. 2010 Dec; 59(12):3066-73. PMID: 20841610.
    Citations: 55     Fields:    Translation:Animals
  70. Wan JB, Huang LL, Rong R, Tan R, Wang J, Kang JX. Endogenously decreasing tissue n-6/n-3 fatty acid ratio reduces atherosclerotic lesions in apolipoprotein E-deficient mice by inhibiting systemic and vascular inflammation. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2487-94. PMID: 20705919.
    Citations: 33     Fields:    Translation:AnimalsCells
  71. Lau BY, Ward WE, Kang JX, Ma DW. Fat-1 gene modulates the fatty acid composition of femoral and vertebral phospholipids. Appl Physiol Nutr Metab. 2010 Aug; 35(4):447-55. PMID: 20725110.
    Citations: 5     Fields:    Translation:Animals
  72. Gravaghi C, La Perle KM, Ogrodwski P, Kang JX, Quimby F, Lipkin M, Lamprecht SA. Cox-2 expression, PGE(2) and cytokines production are inhibited by endogenously synthesized n-3 PUFAs in inflamed colon of fat-1 mice. J Nutr Biochem. 2011 Apr; 22(4):360-5. PMID: 20655721.
    Citations: 28     Fields:    Translation:Animals
  73. Shen LR, Lai CQ, Feng X, Parnell LD, Wan JB, Wang JD, Li D, Ordovas JM, Kang JX. Drosophila lacks C20 and C22 PUFAs. J Lipid Res. 2010 Oct; 51(10):2985-92. PMID: 20656917.
    Citations: 27     Fields:    Translation:Animals
  74. Orr SK, Tong JY, Kang JX, Ma DW, Bazinet RP. The fat-1 mouse has brain docosahexaenoic acid levels achievable through fish oil feeding. Neurochem Res. 2010 May; 35(5):811-9. PMID: 20177777.
    Citations: 12     Fields:    Translation:Animals
  75. Boudrault C, Bazinet RP, Kang JX, Ma DW. Cyclooxygenase-2 and n-6 PUFA are lower and DHA is higher in the cortex of fat-1 mice. Neurochem Int. 2010 Mar; 56(4):585-9. PMID: 20064570.
    Citations: 8     Fields:    Translation:AnimalsCells
  76. Wan JB, Lee SM, Wang JD, Wang N, He CW, Wang YT, Kang JX. Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF-alpha-induced endothelial adhesion molecule expression and monocyte adhesion. J Agric Food Chem. 2009 Aug 12; 57(15):6692-7. PMID: 19722574.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  77. Rahman MM, Bhattacharya A, Banu J, Kang JX, Fernandes G. Endogenous n-3 fatty acids protect ovariectomy induced bone loss by attenuating osteoclastogenesis. J Cell Mol Med. 2009 Aug; 13(8B):1833-44. PMID: 20141608.
    Citations: 33     Fields:    Translation:AnimalsCells
  78. He C, Qu X, Cui L, Wang J, Kang JX. Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11370-5. PMID: 19549874.
    Citations: 67     Fields:    Translation:AnimalsCells
  79. Lau BY, Ward WE, Kang JX, Ma DW. Vertebrae of developing fat-1 mice have greater strength and lower n-6/n-3 fatty acid ratio. Exp Biol Med (Maywood). 2009 Jun; 234(6):632-8. PMID: 19307460.
    Citations: 8     Fields:    Translation:Animals
  80. Habbel P, Weylandt KH, Lichopoj K, Nowak J, Purschke M, Wang JD, He CW, Baumgart DC, Kang JX. Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells. World J Gastroenterol. 2009 Mar 07; 15(9):1079-84. PMID: 19266600.
    Citations: 6     Fields:    Translation:HumansCells
  81. Suh M, Sauvé Y, Merrells KJ, Kang JX, Ma DW. Supranormal electroretinogram in fat-1 mice with retinas enriched in docosahexaenoic acid and n-3 very long chain fatty acids (C24-C36). Invest Ophthalmol Vis Sci. 2009 Sep; 50(9):4394-401. PMID: 19264893.
    Citations: 11     Fields:    Translation:AnimalsCells
  82. Ménesi D, Kitajka K, Molnár E, Kis Z, Belleger J, Narce M, Kang JX, Puskás LG, Das UN. Gene and protein expression profiling of the fat-1 mouse brain. Prostaglandins Leukot Essent Fatty Acids. 2009 Jan; 80(1):33-42. PMID: 19138887.
    Citations: 6     Fields:    Translation:Animals
  83. Mayer K, Kiessling A, Ott J, Schaefer MB, Hecker M, Henneke I, Schulz R, Günther A, Wang J, Wu L, Roth J, Seeger W, Kang JX. Acute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids. Am J Respir Crit Care Med. 2009 Mar 15; 179(6):474-83. PMID: 19136374.
    Citations: 21     Fields:    Translation:AnimalsCells
  84. Freudiger CW, Min W, Saar BG, Lu S, Holtom GR, He C, Tsai JC, Kang JX, Xie XS. Label-free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy. Science. 2008 Dec 19; 322(5909):1857-61. PMID: 19095943.
    Citations: 384     Fields:    Translation:HumansAnimalsCells
  85. Liu J, He C, Zhou K, Wang J, Kang JX. Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cells. Biochem Biophys Res Commun. 2009 Jan 09; 378(2):174-8. PMID: 19000652.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  86. Araujo P, Nguyen TT, Frøyland L, Wang J, Kang JX. Evaluation of a rapid method for the quantitative analysis of fatty acids in various matrices. J Chromatogr A. 2008 Nov 28; 1212(1-2):106-13. PMID: 18937951.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  87. Weylandt KH, Nadolny A, Kahlke L, Köhnke T, Schmöcker C, Wang J, Lauwers GY, Glickman JN, Kang JX. Reduction of inflammation and chronic tissue damage by omega-3 fatty acids in fat-1 transgenic mice with pancreatitis. Biochim Biophys Acta. 2008 Nov; 1782(11):634-41. PMID: 18832028.
    Citations: 25     Fields:    Translation:Animals
  88. Lau BY, Ward WE, Kang JX, Ma DW. Femur EPA and DHA are correlated with femur biomechanical strength in young fat-1 mice. J Nutr Biochem. 2009 Jun; 20(6):453-61. PMID: 18708283.
    Citations: 13     Fields:    Translation:Animals
  89. Jia Q, Lupton JR, Smith R, Weeks BR, Callaway E, Davidson LA, Kim W, Fan YY, Yang P, Newman RA, Kang JX, McMurray DN, Chapkin RS. Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic mice. Cancer Res. 2008 May 15; 68(10):3985-91. PMID: 18483285.
    Citations: 72     Fields:    Translation:AnimalsCells
  90. Kang JX. A transgenic mouse model for gene-nutrient interactions. J Nutrigenet Nutrigenomics. 2008; 1(4):172-7. PMID: 19776625.
    Citations: 6     Fields:    Translation:Animals
  91. Leaf A, Kang JX, Xiao YF. Fish oil fatty acids as cardiovascular drugs. Curr Vasc Pharmacol. 2008 Jan; 6(1):1-12. PMID: 18220934.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  92. Kang JX, Weylandt KH. Modulation of inflammatory cytokines by omega-3 fatty acids. Subcell Biochem. 2008; 49:133-43. PMID: 18751910.
    Citations: 49     Fields:    Translation:HumansAnimals
  93. Kang JX. Fat-1 transgenic mice: a new model for omega-3 research. Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec; 77(5-6):263-7. PMID: 18042365.
    Citations: 64     Fields:    Translation:Animals
  94. Taha AY, Huot PS, Reza-López S, Prayitno NR, Kang JX, Burnham WM, Ma DW. Seizure resistance in fat-1 transgenic mice endogenously synthesizing high levels of omega-3 polyunsaturated fatty acids. J Neurochem. 2008 Apr; 105(2):380-8. PMID: 18036191.
    Citations: 8     Fields:    Translation:Animals
  95. Nowak J, Weylandt KH, Habbel P, Wang J, Dignass A, Glickman JN, Kang JX. Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids. Carcinogenesis. 2007 Sep; 28(9):1991-5. PMID: 17634405.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  96. Berquin IM, Min Y, Wu R, Wu J, Perry D, Cline JM, Thomas MJ, Thornburg T, Kulik G, Smith A, Edwards IJ, D'Agostino R, Zhang H, Wu H, Kang JX, Chen YQ. Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. J Clin Invest. 2007 Jul; 117(7):1866-75. PMID: 17607361.
    Citations: 109     Fields:    Translation:AnimalsCells
  97. Connor KM, SanGiovanni JP, Lofqvist C, Aderman CM, Chen J, Higuchi A, Hong S, Pravda EA, Majchrzak S, Carper D, Hellstrom A, Kang JX, Chew EY, Salem N, Serhan CN, Smith LEH. Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med. 2007 Jul; 13(7):868-873. PMID: 17589522.
    Citations: 276     Fields:    Translation:Animals
  98. Liu YE, Pu W, Wang J, Kang JX, Shi YE. Activation of Stat5 and induction of a pregnancy-like mammary gland differentiation by eicosapentaenoic and docosapentaenoic omega-3 fatty acids. FEBS J. 2007 Jul; 274(13):3351-62. PMID: 17547694.
    Citations: 8     Fields:    Translation:Animals
  99. Weylandt KH, Kang JX, Wiedenmann B, Baumgart DC. Lipoxins and resolvins in inflammatory bowel disease. Inflamm Bowel Dis. 2007 Jun; 13(6):797-9. PMID: 17262807.
    Citations: 17     Fields:    Translation:HumansAnimals
  100. Kang JX, Leaf A. Why the omega-3 piggy should go to market. Nat Biotechnol. 2007 May; 25(5):505-6; author reply 506. PMID: 17483827.
    Citations: 1     Fields:    Translation:Animals
  101. Schmöcker C, Weylandt KH, Kahlke L, Wang J, Lobeck H, Tiegs G, Berg T, Kang JX. Omega-3 fatty acids alleviate chemically induced acute hepatitis by suppression of cytokines. Hepatology. 2007 Apr; 45(4):864-9. PMID: 17393517.
    Citations: 47     Fields:    Translation:Animals
  102. Sung B, Wang S, Zhou B, Lim G, Yang L, Zeng Q, Lim JA, Wang JD, Kang JX, Mao J. Altered spinal arachidonic acid turnover after peripheral nerve injury regulates regional glutamate concentration and neuropathic pain behaviors in rats. Pain. 2007 Sep; 131(1-2):121-31. PMID: 17267128.
    Citations: 17     Fields:    Translation:Animals
  103. Bhattacharya A, Chandrasekar B, Rahman MM, Banu J, Kang JX, Fernandes G. Inhibition of inflammatory response in transgenic fat-1 mice on a calorie-restricted diet. Biochem Biophys Res Commun. 2006 Oct 27; 349(3):925-30. PMID: 16962071.
    Citations: 20     Fields:    Translation:AnimalsCells
  104. Xia S, Lu Y, Wang J, He C, Hong S, Serhan CN, Kang JX. Melanoma growth is reduced in fat-1 transgenic mice: impact of omega-6/omega-3 essential fatty acids. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12499-504. PMID: 16888035.
    Citations: 45     Fields:    Translation:AnimalsCells
  105. Hudert CA, Weylandt KH, Lu Y, Wang J, Hong S, Dignass A, Serhan CN, Kang JX. Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11276-81. PMID: 16847262.
    Citations: 132     Fields:    Translation:Animals
  106. Li R, Lai L, Wax D, Hao Y, Murphy CN, Rieke A, Samuel M, Linville ML, Korte SW, Evans RW, Turk JR, Kang JX, Witt WT, Dai Y, Prather RS. Cloned transgenic swine via in vitro production and cryopreservation. Biol Reprod. 2006 Aug; 75(2):226-30. PMID: 16672718.
    Citations: 11     Fields:    Translation:AnimalsCells
  107. Lai L, Kang JX, Li R, Wang J, Witt WT, Yong HY, Hao Y, Wax DM, Murphy CN, Rieke A, Samuel M, Linville ML, Korte SW, Evans RW, Starzl TE, Prather RS, Dai Y. Generation of cloned transgenic pigs rich in omega-3 fatty acids. Nat Biotechnol. 2006 Apr; 24(4):435-6. PMID: 16565727.
    Citations: 90     Fields:    Translation:HumansAnimals
  108. Ma DW, Ngo V, Huot PS, Kang JX. N-3 polyunsaturated fatty acids endogenously synthesized in fat-1 mice are enriched in the mammary gland. Lipids. 2006 Jan; 41(1):35-9. PMID: 16555469.
    Citations: 12     Fields:    Translation:Animals
  109. Leaf A, Albert CM, Josephson M, Steinhaus D, Kluger J, Kang JX, Cox B, Zhang H, Schoenfeld D. Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake. Circulation. 2005 Nov 01; 112(18):2762-8. PMID: 16267249.
    Citations: 81     Fields:    Translation:Humans
  110. Weylandt KH, Kang JX. Rethinking lipid mediators. Lancet. 2005 Aug 20-26; 366(9486):618-20. PMID: 16112288.
    Citations: 10     Fields:    Translation:Humans
  111. Kang JX, Liu J, Wang J, He C, Li FP. The extract of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by upregulation of interferon-beta and TNF-alpha in human breast cancer cells. Carcinogenesis. 2005 Nov; 26(11):1934-9. PMID: 15958519.
    Citations: 29     Fields:    Translation:HumansCells
  112. Kang JX, Wang J. A simplified method for analysis of polyunsaturated fatty acids. BMC Biochem. 2005 Mar 24; 6:5. PMID: 15790399.
    Citations: 60     Fields:    Translation:Animals
  113. Xia SH, Wang J, Kang JX. Decreased n-6/n-3 fatty acid ratio reduces the invasive potential of human lung cancer cells by downregulation of cell adhesion/invasion-related genes. Carcinogenesis. 2005 Apr; 26(4):779-84. PMID: 15661810.
    Citations: 25     Fields:    Translation:HumansCells
  114. Kang JX. Balance of omega-6/omega-3 essential fatty acids is important for health. The evidence from gene transfer studies. World Rev Nutr Diet. 2005; 95:93-102. PMID: 16151274.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  115. Leaf A, Kang JX, Xiao YF. Omega-3 fatty acids and ventricular arrhythmias. World Rev Nutr Diet. 2005; 94:129-138. PMID: 16145258.
    Citations: 2     Fields:    Translation:HumansAnimals
  116. Chen Z, Ge Y, Kang JX. Down-regulation of the M6P/IGF-II receptor increases cell proliferation and reduces apoptosis in neonatal rat cardiac myocytes. BMC Cell Biol. 2004 Apr 28; 5:15. PMID: 15115542.
    Citations: 9     Fields:    Translation:AnimalsCells
  117. Kang JX, Wang J, Wu L, Kang ZB. Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids. Nature. 2004 Feb 05; 427(6974):504. PMID: 14765186.
    Citations: 208     Fields:    Translation:Animals
  118. Kang JX. Achieving balance in the omega-6/omega-3 ratio through nutrigenomics. World Rev Nutr Diet. 2004; 93:92-8. PMID: 15496803.
    Citations: 1     Fields:    Translation:Animals
  119. Leaf A, Kang JX, Xiao YF, Billman GE. Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils. Circulation. 2003 Jun 03; 107(21):2646-52. PMID: 12782616.
    Citations: 128     Fields:    Translation:HumansAnimalsCells
  120. Leaf A, Xiao YF, Kang JX, Billman GE. Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids. Pharmacol Ther. 2003 Jun; 98(3):355-77. PMID: 12782244.
    Citations: 36     Fields:    Translation:HumansAnimals
  121. Kang JX. The importance of omega-6/omega-3 fatty acid ratio in cell function. The gene transfer of omega-3 fatty acid desaturase. World Rev Nutr Diet. 2003; 92:23-36. PMID: 14579681.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  122. Ge Y, Wang X, Chen Z, Landman N, Lo EH, Kang JX. Gene transfer of the Caenorhabditis elegans n-3 fatty acid desaturase inhibits neuronal apoptosis. J Neurochem. 2002 Sep; 82(6):1360-6. PMID: 12354283.
    Citations: 10     Fields:    Translation:AnimalsCells
  123. Xie S, Kang JX. Differential expression of the mannose 6-phosphate/ insulin-like growth factor-II receptor in human breast cancer cell lines of different invasive potential. Med Sci Monit. 2002 Aug; 8(8):BR293-300. PMID: 12165733.
    Citations: 2     Fields:    Translation:HumansCells
  124. Chen Z, Ge Y, Landman N, Kang JX. Decreased expression of the mannose 6-phosphate/insulin-like growth factor-II receptor promotes growth of human breast cancer cells. BMC Cancer. 2002 Jul 30; 2:18. PMID: 12149131.
    Citations: 16     Fields:    Translation:HumansCells
  125. Ge Y, Chen Z, Kang ZB, Cluette-Brown J, Laposata M, Kang JX. Effects of adenoviral gene transfer of C. elegans n-3 fatty acid desaturase on the lipid profile and growth of human breast cancer cells. Anticancer Res. 2002 Mar-Apr; 22(2A):537-43. PMID: 12014621.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  126. Kang JX, Bell J, Beard RL, Chandraratna RA. Mannose 6-phosphate/insulin-like growth factor II receptor mediates the growth-inhibitory effects of retinoids. Cell Growth Differ. 1999 Aug; 10(8):591-600. PMID: 10470859.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  127. Kang JX, Bell J, Leaf A, Beard RL, Chandraratna RA. Retinoic acid alters the intracellular trafficking of the mannose-6-phosphate/insulin-like growth factor II receptor and lysosomal enzymes. Proc Natl Acad Sci U S A. 1998 Nov 10; 95(23):13687-91. PMID: 9811861.
    Citations: 14     Fields:    Translation:AnimalsCells
  128. Kang JX, Li Y, Leaf A. Mannose-6-phosphate/insulin-like growth factor-II receptor is a receptor for retinoic acid. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):13671-6. PMID: 9391084.
    Citations: 23     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.