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Brian Patrick Brennan, M.D.

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Biography
2008
NARSAD Young Investigator Award
2008
McLean Hospital Alfred Pope Award for Young Investigators

Overview
Dr. Brennan received a B.A. degree from the University of Pennsylvania in 1994 and later received his M.D. degree from the University of Pennsylvania School of Medicine in 2000. After completing an internship in internal medicine at Pennsylvania Hospital he went on to do his residency training in psychiatry at the Massachusetts General Hospital and McLean Hospital. Following completion of his training he worked as an attending psychiatrist on the Schizophrenia and Bipolar Disorder inpatient unit at McLean Hospital and later completed a two-year research fellowship in the Biological Psychiatry Laboratory. During this time he acquired extensive experience in the design and execution of clinical trials investigating novel treatments for a variety of psychiatric disorders including mood disorders, anxiety disorders, and eating disorders. He later received a M.Sc. degree from the Harvard-MIT Division of Health Sciences and Technology through the Clinical Investigator Training Program. His primary research interest is in the development of novel pharmacologic treatments for mood disorders through the translation of basic science discoveries into human treatment trials and the use of magnetic resonance spectroscopy to identify biochemical biomarkers of treatment response. Specifically, his current interests include the investigation of glutamate-modulating drugs and mitochondrial enhancement treatments for bipolar disorder and the use of hormonal interventions including testosterone and DHEA in the treatment of refractory depression.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K23MH092397 (BRENNAN, BRIAN P.) Jul 5, 2011 - Apr 30, 2016
    NIH/NIMH
    Glutamatergic Mediators of Antidepressant Response in Major Depression
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Boedhoe PSW, van Rooij D, Hoogman M, Twisk JWR, Schmaal L, Abe Y, Alonso P, Ameis SH, Anikin A, Anticevic A, Arango C, Arnold PD, Asherson P, Assogna F, Auzias G, Banaschewski T, Baranov A, Batistuzzo MC, Baumeister S, Baur-Streubel R, Behrmann M, Bellgrove MA, Benedetti F, Beucke JC, Biederman J, Bollettini I, Bose A, Bralten J, Bramati IE, Brandeis D, Brem S, Brennan BP, Busatto GF, Calderoni S, Calvo A, Calvo R, Castellanos FX, Cercignani M, Chaim-Avancini TM, Chantiluke KC, Cheng Y, Cho KIK, Christakou A, Coghill D, Conzelmann A, Cubillo AI, Dale AM, Dallaspezia S, Daly E, Denys D, Deruelle C, Di Martino A, Dinstein I, Doyle AE, Durston S, Earl EA, Ecker C, Ehrlich S, Ely BA, Epstein JN, Ethofer T, Fair DA, Fallgatter AJ, Faraone SV, Fedor J, Feng X, Feusner JD, Fitzgerald J, Fitzgerald KD, Fouche JP, Freitag CM, Fridgeirsson EA, Frodl T, Gabel MC, Gallagher L, Gogberashvili T, Gori I, Gruner P, Gürsel DA, Haar S, Haavik J, Hall GB, Harrison NA, Hartman CA, Heslenfeld DJ, Hirano Y, Hoekstra PJ, Hoexter MQ, Hohmann S, Høvik MF, Hu H, Huyser C, Jahanshad N, Jalbrzikowski M, James A, Janssen J, Jaspers-Fayer F, Jernigan TL, Kapilushniy D, Kardatzki B, Karkashadze G, Kathmann N, Kaufmann C, Kelly C, Khadka S, King JA, Koch K, Kohls G, Konrad K, Kuno M, Kuntsi J, Kvale G, Kwon JS, Lázaro L, Lera-Miguel S, Lesch KP, Hoekstra L, Liu Y, Lochner C, Louza MR, Luna B, Lundervold AJ, Malpas CB, Marques P, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Mattos P, McCarthy H, McGrath J, Mehta MA, Menchón JM, Mennes M, Martinho MM, Moreira PS, Morer A, Morgado P, Muratori F, Murphy CM, Murphy DGM, Nakagawa A, Nakamae T, Nakao T, Namazova-Baranova L, Narayanaswamy JC, Nicolau R, Nigg JT, Novotny SE, Nurmi EL, Weiss EO, O'Gorman Tuura RL, O'Hearn K, O'Neill J, Oosterlaan J, Oranje B, Paloyelis Y, Parellada M, Pauli P, Perriello C, Piacentini J, Piras F, Piras F, Plessen KJ, Puig O, Ramos-Quiroga JA, Reddy YCJ, Reif A, Reneman L, Retico A, Rosa PGP, Rubia K, Rus OG, Sakai Y, Schrantee A, Schwarz L, Schweren LJS, Seitz J, Shaw P, Shook D, Silk TJ, Simpson HB, Skokauskas N, Soliva Vila JC, Solovieva A, Soreni N, Soriano-Mas C, Spalletta G, Stern ER, Stevens MC, Stewart SE, Sudre G, Szeszko PR, Tamm L, Taylor MJ, Tolin DF, Tosetti M, Tovar-Moll F, Tsuchiyagaito A, van Erp TGM, van Wingen GA, Vance A, Venkatasubramanian G, Vilarroya O, Vives-Gilabert Y, von Polier GG, Walitza S, Wallace GL, Wang Z, Wolfers T, Yoncheva YN, Yun JY, Zanetti MV, Zhou F, Ziegler GC, Zierhut KC, Zwiers MP, Thompson PM, Stein DJ, Buitelaar J, Franke B, van den Heuvel OA. Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups. Am J Psychiatry. 2020 Jun 16; appiajp202019030331. PMID: 32539527.
    Citations:    
  2. van den Heuvel OA, Boedhoe PSW, Bertolin S, Bruin WB, Francks C, Ivanov I, Jahanshad N, Kong XZ, Kwon JS, O'Neill J, Paus T, Patel Y, Piras F, Schmaal L, Soriano-Mas C, Spalletta G, van Wingen GA, Yun JY, Vriend C, Simpson HB, van Rooij D, Hoexter MQ, Hoogman M, Buitelaar JK, Arnold P, Beucke JC, Benedetti F, Bollettini I, Bose A, Brennan BP, De Nadai AS, Fitzgerald K, Gruner P, Grünblatt E, Hirano Y, Huyser C, James A, Koch K, Kvale G, Lazaro L, Lochner C, Marsh R, Mataix-Cols D, Morgado P, Nakamae T, Nakao T, Narayanaswamy JC, Nurmi E, Pittenger C, Reddy YCJ, Sato JR, Soreni N, Stewart SE, Taylor SF, Tolin D, Thomopoulos SI, Veltman DJ, Venkatasubramanian G, Walitza S, Wang Z, Thompson PM, Stein DJ. An overview of the first 5?years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration. Hum Brain Mapp. 2020 Mar 10. PMID: 32154629.
    Citations:    
  3. Kong XZ, Boedhoe PSW, Abe Y, Alonso P, Ameis SH, Arnold PD, Assogna F, Baker JT, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Brennan BP, Buitelaar J, Calvo R, Cheng Y, Cho KIK, Dallaspezia S, Denys D, Ely BA, Feusner J, Fitzgerald KD, Fouche JP, Fridgeirsson EA, Glahn DC, Gruner P, Gürsel DA, Hauser TU, Hirano Y, Hoexter MQ, Hu H, Huyser C, James A, Jaspers-Fayer F, Kathmann N, Kaufmann C, Koch K, Kuno M, Kvale G, Kwon JS, Lazaro L, Liu Y, Lochner C, Marques P, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Medland SE, Menchón JM, Minuzzi L, Moreira PS, Morer A, Morgado P, Nakagawa A, Nakamae T, Nakao T, Narayanaswamy JC, Nurmi EL, O'Neill J, Pariente JC, Perriello C, Piacentini J, Piras F, Piras F, Pittenger C, Reddy YCJ, Rus-Oswald OG, Sakai Y, Sato JR, Schmaal L, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Tolin DF, Tsuchiyagaito A, van Rooij D, van Wingen GA, Venkatasubramanian G, Wang Z, Yun JY, Thompson PM, Stein DJ, van den Heuvel OA, Francks C. Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium. Biol Psychiatry. 2020 Jun 15; 87(12):1022-1034. PMID: 31178097.
    Citations:    
  4. Li M, Wang D, Ren J, Langs G, Stoecklein S, Brennan BP, Lu J, Chen H, Liu H. Performing group-level functional image analyses based on homologous functional regions mapped in individuals. PLoS Biol. 2019 03; 17(3):e2007032. PMID: 30908490.
    Citations:    
  5. Falkenstein MJ, Nota JA, Krompinger JW, Schreck M, Garner LE, Potluri S, Van Kirk N, Ponzini G, Tifft E, Brennan BP, Mathes B, Cattie J, Crosby JM, Elias JA. Empirically-derived response trajectories of intensive residential treatment in obsessive-compulsive disorder: A growth mixture modeling approach. J Affect Disord. 2019 02 15; 245:827-833. PMID: 30699866.
    Citations:    Fields:    
  6. Brennan BP, Jacoby RJ, Widge AS. A Case of Severe Intractable Contamination-Based Obsessive-Compulsive Disorder. JAMA Psychiatry. 2018 10 01; 75(10):1088-1089. PMID: 30128485.
    Citations:    Fields:    
  7. Dougherty DD, Brennan BP, Stewart SE, Wilhelm S, Widge AS, Rauch SL. Neuroscientifically Informed Formulation and Treatment Planning for Patients With Obsessive-Compulsive Disorder: A Review. JAMA Psychiatry. 2018 10 01; 75(10):1081-1087. PMID: 30140845.
    Citations:    Fields:    
  8. Brennan BP, Wang D, Li M, Perriello C, Ren J, Elias JA, Van Kirk NP, Krompinger JW, Pope HG, Haber SN, Rauch SL, Baker JT, Liu H. Use of an Individual-Level Approach to Identify Cortical Connectivity Biomarkers in Obsessive-Compulsive Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 01; 4(1):27-38. PMID: 30262337.
    Citations:    Fields:    
  9. Gagné JP, Van Kirk N, Hernandez-Vallant A, Potluri S, Krompinger JW, Cattie JE, Garner LE, Crosby JM, Brennan BP, Elias JA. Validating an abbreviated version of the Obsessive Beliefs Questionnaire. J Clin Psychol. 2018 10; 74(10):1791-1807. PMID: 29696644.
    Citations:    Fields:    
  10. Garner LE, Van Kirk N, Tifft ED, Krompinger JW, Mathes BM, Fraire M, Falkenstein MJ, Brennan BP, Crosby JM, Elias JA. Validation of the distress tolerance scale-short form in obsessive compulsive disorder. J Clin Psychol. 2018 06; 74(6):916-925. PMID: 29139125.
    Citations:    Fields:    
  11. Brennan BP, Admon R, Perriello C, LaFlamme EM, Athey AJ, Pizzagalli DA, Hudson JI, Pope HG, Jensen JE. Acute change in anterior cingulate cortex GABA, but not glutamine/glutamate, mediates antidepressant response to citalopram. Psychiatry Res Neuroimaging. 2017 Nov 30; 269:9-16. PMID: 28892734.
    Citations:    Translation:HumansCTClinical Trials
  12. Reid AM, Garner LE, Van Kirk N, Gironda C, Krompinger JW, Brennan BP, Mathes BM, Monaghan SC, Tifft ED, André MC, Cattie J, Crosby JM, Elias JA. How willing are you? Willingness as a predictor of change during treatment of adults with obsessive-compulsive disorder. Depress Anxiety. 2017 11; 34(11):1057-1064. PMID: 28715850.
    Citations:    Fields:    Translation:Humans
  13. Brennan BP, Jensen JE, Perriello C, Pope HG, Jenike MA, Hudson JI, Rauch SL, Kaufman MJ. LOWER POSTERIOR CINGULATE CORTEX GLUTATHIONE LEVELS IN OBSESSIVE-COMPULSIVE DISORDER. Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Feb 01; 1(2):116-124. PMID: 26949749.
    Citations: 2     Fields:    
  14. Kaufman MJ, Janes AC, Hudson JI, Brennan BP, Kanayama G, Kerrigan AR, Jensen JE, Pope HG. Brain and cognition abnormalities in long-term anabolic-androgenic steroid users. Drug Alcohol Depend. 2015 Jul 01; 152:47-56. PMID: 25986964.
    Citations: 7     Fields:    Translation:Humans
  15. Brennan BP, Tkachenko O, Schwab ZJ, Juelich RJ, Ryan EM, Athey AJ, Pope HG, Jenike MA, Baker JT, Killgore WD, Hudson JI, Jensen JE, Rauch SL. An Examination of Rostral Anterior Cingulate Cortex Function and Neurochemistry in Obsessive-Compulsive Disorder. Neuropsychopharmacology. 2015 Jul; 40(8):1866-76. PMID: 25662837.
    Citations: 8     Fields:    Translation:Humans
  16. Athey AJ, Elias JA, Crosby JM, Jenike MA, Pope HG, Hudson JI, Brennan BP. REDUCED DISGUST PROPENSITY IS ASSOCIATED WITH IMPROVEMENT IN CONTAMINATION/WASHING SYMPTOMS IN OBSESSIVE-COMPULSIVE DISORDER. J Obsessive Compuls Relat Disord. 2015 Jan 01; 4:20-24. PMID: 25485229.
    Citations: 1     
  17. Ferrari A, De Salvo GL, Brennan B, van Noesel MM, De Paoli A, Casanova M, Francotte N, Kelsey A, Alaggio R, Oberlin O, Carli M, Ben-Arush M, Bergeron C, Merks JH, Jenney M, Stevens MC, Bisogno G, Orbach D. Synovial sarcoma in children and adolescents: the European Pediatric Soft Tissue Sarcoma Study Group prospective trial (EpSSG NRSTS 2005). Ann Oncol. 2015 Mar; 26(3):567-72. PMID: 25488687.
    Citations:    
  18. Brennan BP, Lee C, Elias JA, Crosby JM, Mathes BM, Andre MC, Gironda CM, Pope HG, Jenike MA, Fitzmaurice GM, Hudson JI. Intensive residential treatment for severe obsessive-compulsive disorder: characterizing treatment course and predictors of response. J Psychiatr Res. 2014 Sep; 56:98-105. PMID: 24909787.
    Citations: 3     Fields:    Translation:Humans
  19. Brennan BP, Jensen JE, Hudson JI, Coit CE, Beaulieu A, Pope HG, Renshaw PF, Cohen BM. A placebo-controlled trial of acetyl-L-carnitine and a-lipoic acid in the treatment of bipolar depression. J Clin Psychopharmacol. 2013 Oct; 33(5):627-35. PMID: 23948785.
    Citations: 3     Fields:    Translation:HumansCells
  20. Brennan BP, Kanayama G, Pope HG. Performance-enhancing drugs on the web: a growing public-health issue. Am J Addict. 2013 Mar-Apr; 22(2):158-61. PMID: 23414502.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  21. Brennan BP, Rauch SL, Jensen JE, Pope HG. A critical review of magnetic resonance spectroscopy studies of obsessive-compulsive disorder. Biol Psychiatry. 2013 Jan 01; 73(1):24-31. PMID: 22831979.
    Citations: 26     Fields:    Translation:Humans
  22. Nierenberg AA, Kansky C, Brennan BP, Shelton RC, Perlis R, Iosifescu DV. Mitochondrial modulators for bipolar disorder: a pathophysiologically informed paradigm for new drug development. Aust N Z J Psychiatry. 2013 Jan; 47(1):26-42. PMID: 22711881.
    Citations: 18     Fields:    Translation:HumansCells
  23. Amiaz R, Pope HG, Mahne T, Kelly JF, Brennan BP, Kanayama G, Weiser M, Hudson JI, Seidman SN. Testosterone gel replacement improves sexual function in depressed men taking serotonergic antidepressants: a randomized, placebo-controlled clinical trial. J Sex Marital Ther. 2011; 37(4):243-54. PMID: 21707327.
    Citations: 8     Fields:    Translation:Humans
  24. Brennan BP, Kanayama G, Hudson JI, Pope HG. Human growth hormone abuse in male weightlifters. Am J Addict. 2011 Jan-Feb; 20(1):9-13. PMID: 21175915.
    Citations: 12     Fields:    Translation:Humans
  25. Pope HG, Amiaz R, Brennan BP, Orr G, Weiser M, Kelly JF, Kanayama G, Siegel A, Hudson JI, Seidman SN. Parallel-group placebo-controlled trial of testosterone gel in men with major depressive disorder displaying an incomplete response to standard antidepressant treatment. J Clin Psychopharmacol. 2010 Apr; 30(2):126-34. PMID: 20520285.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  26. Brennan BP, Hudson JI, Jensen JE, McCarthy J, Roberts JL, Prescot AP, Cohen BM, Pope HG, Renshaw PF, Ongür D. Rapid enhancement of glutamatergic neurotransmission in bipolar depression following treatment with riluzole. Neuropsychopharmacology. 2010 Feb; 35(3):834-46. PMID: 19956089.
    Citations: 54     Fields:    Translation:HumansCells
  27. Brennan BP, Fogarty KV, Roberts JL, Reynolds KA, Pope HG, Hudson JI. Duloxetine in the treatment of irritable bowel syndrome: an open-label pilot study. Hum Psychopharmacol. 2009 Jul; 24(5):423-8. PMID: 19548294.
    Citations: 12     Fields:    Translation:HumansCTClinical Trials
  28. Brennan BP, Roberts JL, Fogarty KV, Reynolds KA, Jonas JM, Hudson JI. Memantine in the treatment of binge eating disorder: an open-label, prospective trial. Int J Eat Disord. 2008 Sep; 41(6):520-6. PMID: 18433015.
    Citations: 14     Fields:    Translation:HumansCTClinical Trials
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.