Harvard Catalyst Profiles

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Hetian Lei, Ph.D.


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  1. R01EY012509 (LEI, HETIAN) Aug 1, 2000 - Jan 31, 2018
    PDGF and PVR
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wu W, Yang Y, Lei H. Progress in the application of CRISPR: From gene to base editing. Med Res Rev. 2019 03; 39(2):665-683. PMID: 30171624.
    Citations: 1     Fields:    
  2. Xu Z, Xin T, Bartels D, Li Y, Gu W, Yao H, Liu S, Yu H, Pu X, Zhou J, Xu J, Xi C, Lei H, Song J, Chen S. Genome Analysis of the Ancient Tracheophyte Selaginella tamariscina Reveals Evolutionary Features Relevant to the Acquisition of Desiccation Tolerance. Mol Plant. 2018 07 02; 11(7):983-994. PMID: 29777775.
    Citations:    Fields:    
  3. Shi L, Zhang N, Liu H, Zhao L, Liu J, Wan J, Wu W, Lei H, Liu R, Han M. Lysyl oxidase inhibition via ß-aminoproprionitrile hampers human umbilical vein endothelial cell angiogenesis and migration in vitro. Mol Med Rep. 2018 Apr; 17(4):5029-5036. PMID: 29393489.
    Citations:    Fields:    Translation:HumansCells
  4. Wu W, Duan Y, Ma G, Zhou G, Park-Windhol C, D'Amore PA, Lei H. AAV-CRISPR/Cas9-Mediated Depletion of VEGFR2 Blocks Angiogenesis In Vitro. Invest Ophthalmol Vis Sci. 2017 12 01; 58(14):6082-6090. PMID: 29204648.
    Citations: 2     Fields:    Translation:HumansCells
  5. Zhou G, Duan Y, Ma G, Wu W, Hu Z, Chen N, Chee Y, Cui J, Samad A, Matsubara JA, Mukai S, D'Amore PA, Lei H. Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy. Invest Ophthalmol Vis Sci. 2017 10 01; 58(12):5361-5367. PMID: 29049737.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Huang X, Zhou G, Wu W, Duan Y, Ma G, Song J, Xiao R, Vandenberghe L, Zhang F, D'Amore PA, Lei H. Genome editing abrogates angiogenesis in vivo. Nat Commun. 2017 07 24; 8(1):112. PMID: 28740073.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  7. Wu W, Tang L, D'Amore PA, Lei H. Application of CRISPR-Cas9 in eye disease. Exp Eye Res. 2017 08; 161:116-123. PMID: 28619505.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  8. Wu W, Lei H, Shen J, Tang L. The role of netrin-1 in angiogenesis and diabetic retinopathy: a promising therapeutic strategy. Discov Med. 2017 05; 23(128):315-323. PMID: 28715647.
    Citations: 1     Fields:    Translation:HumansAnimals
  9. Huang X, Zhou G, Wu W, Ma G, D'Amore PA, Mukai S, Lei H. Editing VEGFR2 Blocks VEGF-Induced Activation of Akt and Tube Formation. Invest Ophthalmol Vis Sci. 2017 02 01; 58(2):1228-1236. PMID: 28241310.
    Citations: 5     Fields:    Translation:HumansCells
  10. Sriram S, Tran JA, Guo X, Hutcheon AE, Lei H, Kazlauskas A, Zieske JD. PDGFRa Is a Key Regulator of T1 and T3's Differential Effect on SMA Expression in Human Corneal Fibroblasts. Invest Ophthalmol Vis Sci. 2017 02 01; 58(2):1179-1186. PMID: 28245298.
    Citations:    Fields:    Translation:HumansCells
  11. Ma G, Duan Y, Huang X, Qian CX, Chee Y, Mukai S, Cui J, Samad A, Matsubara JA, Kazlauskas A, D'Amore PA, Gu S, Lei H. Prevention of Proliferative Vitreoretinopathy by Suppression of Phosphatidylinositol 5-Phosphate 4-Kinases. Invest Ophthalmol Vis Sci. 2016 07 01; 57(8):3935-43. PMID: 27472081.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  12. Duan Y, Ma G, Huang X, D'Amore PA, Zhang F, Lei H. The Clustered, Regularly Interspaced, Short Palindromic Repeats-associated Endonuclease 9 (CRISPR/Cas9)-created MDM2 T309G Mutation Enhances Vitreous-induced Expression of MDM2 and Proliferation and Survival of Cells. J Biol Chem. 2016 07 29; 291(31):16339-47. PMID: 27246850.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  13. Lei H, Qian CX, Lei J, Haddock LJ, Mukai S, Kazlauskas A. RasGAP Promotes Autophagy and Thereby Suppresses Platelet-Derived Growth Factor Receptor-Mediated Signaling Events, Cellular Responses, and Pathology. Mol Cell Biol. 2015 May; 35(10):1673-85. PMID: 25733681.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  14. Lei H, Kazlauskas A. A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor a. Mol Cell Biol. 2014 Jan; 34(1):110-22. PMID: 24190966.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  15. Velez G, Weingarden AR, Lei H, Kazlauskas A, Gao G. SU9518 inhibits proliferative vitreoretinopathy in fibroblast and genetically modified Müller cell-induced rabbit models. Invest Ophthalmol Vis Sci. 2013 Feb 19; 54(2):1392-7. PMID: 23341018.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  16. Lei H, Kazlauskas A. Detection of H2O2-mediated phosphorylation of kinase-inactive PDGFRa. Methods Enzymol. 2013; 528:189-94. PMID: 23849866.
    Citations:    Fields:    Translation:HumansCells
  17. Vanarsdall AL, Wisner TW, Lei H, Kazlauskas A, Johnson DC. PDGF receptor-a does not promote HCMV entry into epithelial and endothelial cells but increased quantities stimulate entry by an abnormal pathway. PLoS Pathog. 2012 Sep; 8(9):e1002905. PMID: 23028311.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  18. Lei H, Rheaume MA, Cui J, Mukai S, Maberley D, Samad A, Matsubara J, Kazlauskas A. A novel function of p53: a gatekeeper of retinal detachment. Am J Pathol. 2012 Sep; 181(3):866-74. PMID: 22901751.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  19. Velez G, Weingarden AR, Tucker BA, Lei H, Kazlauskas A, Young MJ. Retinal Pigment Epithelium and Müller Progenitor Cell Interaction Increase Müller Progenitor Cell Expression of PDGFRa and Ability to Induce Proliferative Vitreoretinopathy in a Rabbit Model. Stem Cells Int. 2012; 2012:106486. PMID: 22966235.
    Citations: 6     
  20. Lei H, Rhéaume MA, Velez G, Mukai S, Kazlauskas A. Expression of PDGFRa is a determinant of the PVR potential of ARPE19 cells. Invest Ophthalmol Vis Sci. 2011 Aug 24; 52(9):5016-21. PMID: 21642621.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  21. Tian Z, Shen J, Wang F, Xiao P, Yang J, Lei H, Kazlauskas A, Kohane IS, Wu E. Cambogin is preferentially cytotoxic to cells expressing PDGFR. PLoS One. 2011; 6(6):e21370. PMID: 21712951.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  22. Lei H, Velez G, Kazlauskas A. Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53. Mol Cell Biol. 2011 May; 31(9):1788-99. PMID: 21357737.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  23. Lei H, Velez G, Cui J, Samad A, Maberley D, Matsubara J, Kazlauskas A. N-acetylcysteine suppresses retinal detachment in an experimental model of proliferative vitreoretinopathy. Am J Pathol. 2010 Jul; 177(1):132-40. PMID: 20489144.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  24. Russell MR, Liu Q, Lei H, Kazlauskas A, Fatatis A. The alpha-receptor for platelet-derived growth factor confers bone-metastatic potential to prostate cancer cells by ligand- and dimerization-independent mechanisms. Cancer Res. 2010 May 15; 70(10):4195-203. PMID: 20442296.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  25. Lei H, Rheaume MA, Kazlauskas A. Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy. Exp Eye Res. 2010 Mar; 90(3):376-81. PMID: 19931527.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  26. Lei H, Velez G, Hovland P, Hirose T, Gilbertson D, Kazlauskas A. Growth factors outside the PDGF family drive experimental PVR. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3394-403. PMID: 19324843.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  27. Lei H, Kazlauskas A. Growth factors outside of the platelet-derived growth factor (PDGF) family employ reactive oxygen species/Src family kinases to activate PDGF receptor alpha and thereby promote proliferation and survival of cells. J Biol Chem. 2009 Mar 06; 284(10):6329-36. PMID: 19126548.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  28. Cui J, Lei H, Samad A, Basavanthappa S, Maberley D, Matsubara J, Kazlauskas A. PDGF receptors are activated in human epiretinal membranes. Exp Eye Res. 2009 Mar; 88(3):438-44. PMID: 19032953.
    Citations: 24     Fields:    Translation:HumansCells
  29. Lei H, Velez G, Hovland P, Hirose T, Kazlauskas A. Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2008 Jan; 49(1):42-8. PMID: 18172073.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  30. Lei H, Kazlauskas A. Focus on molecules: platelet-derived growth factor C, PDGF-C. Exp Eye Res. 2008 May; 86(5):711-2. PMID: 17904120.
    Citations: 5     Fields:    Translation:HumansAnimals
  31. Lei H, Hovland P, Velez G, Haran A, Gilbertson D, Hirose T, Kazlauskas A. A potential role for PDGF-C in experimental and clinical proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2007 May; 48(5):2335-42. PMID: 17460299.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  32. Lei H, Venkatakrishnan A, Yu S, Kazlauskas A. Protein kinase A-dependent translocation of Hsp90 alpha impairs endothelial nitric-oxide synthase activity in high glucose and diabetes. J Biol Chem. 2007 Mar 30; 282(13):9364-71. PMID: 17202141.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  33. Lei H, Qi J, Song J, Yang D, Wang Y, Zhang Y, Yang J. Biosynthesis and bioactivity of trichosanthin in cultured crown gall tissues of Trichosanthes kirilowii Maximowicz. Plant Cell Rep. 2006 Nov; 25(11):1205-12. PMID: 16758196.
    Citations:    Fields:    Translation:HumansAnimalsCells
  34. An P, Lei H, Zhang J, Song S, He L, Jin G, Liu X, Wu J, Meng L, Liu M, Shou C. Suppression of tumor growth and metastasis by a VEGFR-1 antagonizing peptide identified from a phage display library. Int J Cancer. 2004 Aug 20; 111(2):165-73. PMID: 15197767.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  35. Lei H, Romeo G, Kazlauskas A. Heat shock protein 90alpha-dependent translocation of annexin II to the surface of endothelial cells modulates plasmin activity in the diabetic rat aorta. Circ Res. 2004 Apr 16; 94(7):902-9. PMID: 15001530.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  36. Lei H, Shou C, Wu J, Liu X, He L, Liu M, Guo Q, Jiang B. [Inhibition of tumor growth by a peptide fusion protein binding to vascular endothelial growth factor receptor Flt-1]. Zhonghua Yi Xue Za Zhi. 2002 Oct 10; 82(19):1342-5. PMID: 12509940.
    Citations:    Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.