Harvard Catalyst Profiles

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Lee Zou, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA248526 (VINDIGNI, ALESSANDRO) Feb 12, 2020 - Jan 31, 2025
    Mechanisms of replication fork protection and recovery
    Role: Co-Principal Investigator
  2. R01CA218856 (ZOU, LEE) May 1, 2018 - Apr 30, 2023
    Impacts of APOBECs on DNA replication, ATR checkpoint, and cancer therapy
    Role: Principal Investigator
  3. R01CA197779 (ZOU, LEE) Jul 1, 2015 - Jun 30, 2020
    Implications of the ATR Checkpoint Kinase in Radiation and Targeted Therapies
    Role: Principal Investigator
  4. R01GM076388 (ZOU, LEE) Sep 25, 2006 - Aug 31, 2019
    Regulation of the ATR Checkpoint Kinase by DNA Damage
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Matson JP, Zou L. A genome-wide and cotranscriptional suppressor of R loops. Genes Dev. 2020 Jul 01; 34(13-14):863-864. PMID: 32611612.
  2. Vidula N, Dubash T, Lawrence MS, Simoneau A, Niemierko A, Blouch E, Nagy B, Roh W, Chirn B, Reeves BA, Malvarosa G, Lennerz J, Isakoff SJ, Juric D, Micalizzi D, Wander S, Spring L, Moy B, Shannon K, Younger J, Lanman R, Toner M, Iafrate AJ, Getz G, Zou L, Ellisen LW, Maheswaran S, Haber DA, Bardia A. Identification of Somatically Acquired BRCA1/2 Mutations by cfDNA Analysis in Patients with Metastatic Breast Cancer. Clin Cancer Res. 2020 Jun 22. PMID: 32571788.
  3. Zhang JM, Zou L. Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks. Cell Biosci. 2020; 10:30. PMID: 32175073.
  4. Tan J, Duan M, Yadav T, Phoon L, Wang X, Zhang JM, Zou L, Lan L. An R-loop-initiated CSB-RAD52-POLD3 pathway suppresses ROS-induced telomeric DNA breaks. Nucleic Acids Res. 2020 02 20; 48(3):1285-1300. PMID: 31777915.
  5. Hopkins JL, Zou L. Induction of BRCAness in Triple-Negative Breast Cancer by a CDK12/13 Inhibitor Improves Chemotherapy. Cancer Cell. 2019 11 11; 36(5):461-463. PMID: 31715127.
  6. Matos DA, Zhang JM, Ouyang J, Nguyen HD, Genois MM, Zou L. ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop. Mol Cell. 2020 02 06; 77(3):514-527.e4. PMID: 31708417.
  7. Gross KM, Zhou W, Breindel JL, Ouyang J, Jin DX, Sokol ES, Gupta PB, Huber K, Zou L, Kuperwasser C. Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium. Cell Rep. 2019 07 09; 28(2):394-407.e6. PMID: 31291576.
  8. Ning JF, Stanciu M, Humphrey MR, Gorham J, Wakimoto H, Nishihara R, Lees J, Zou L, Martuza RL, Wakimoto H, Rabkin SD. Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma. Nat Commun. 2019 07 02; 10(1):2910. PMID: 31266951.
  9. Buisson R, Langenbucher A, Bowen D, Kwan EE, Benes CH, Zou L, Lawrence MS. Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features. Science. 2019 06 28; 364(6447). PMID: 31249028.
  10. Simoneau A, Zou L. Calcium Influx Guards Replication Forks against Exonuclease 1. Mol Cell. 2019 06 20; 74(6):1103-1105. PMID: 31226273.
  11. Parikh AR, He Y, Hong TS, Corcoran RB, Clark JW, Ryan DP, Zou L, Ting DT, Catenacci DV, Chao J, Fakih M, Klempner SJ, Ross JS, Frampton GM, Miller VA, Ali SM, Schrock AB. Analysis of DNA Damage Response Gene Alterations and Tumor Mutational Burden Across 17,486 Tubular Gastrointestinal Carcinomas: Implications for Therapy. Oncologist. 2019 10; 24(10):1340-1347. PMID: 31040255.
  12. Nguyen HD, Zou L, Graubert TA. Targeting R-loop-associated ATR response in myelodysplastic syndrome. Oncotarget. 2019 Apr 05; 10(27):2581-2582. PMID: 31080550.
  13. Ge C, Vilfranc CL, Che L, Pandita RK, Hambarde S, Andreassen PR, Niu L, Olowokure O, Shah S, Waltz SE, Zou L, Wang J, Pandita TK, Du C. The BRUCE-ATR Signaling Axis Is Required for Accurate DNA Replication and Suppression of Liver Cancer Development. Hepatology. 2019 06; 69(6):2608-2622. PMID: 30693543.
  14. Moquin DM, Genois MM, Zhang JM, Ouyang J, Yadav T, Buisson R, Yazinski SA, Tan J, Boukhali M, Gagné JP, Poirier GG, Lan L, Haas W, Zou L. Erratum: Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination. Genes Dev. 2019 02 01; 33(3-4):253. PMID: 30709902.
    Citations:    Fields:    
  15. Zhang JM, Yadav T, Ouyang J, Lan L, Zou L. Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways. Cell Rep. 2019 01 22; 26(4):955-968.e3. PMID: 30673617.
    Citations:    Fields:    
  16. Moquin DM, Genois MM, Zhang JM, Ouyang J, Yadav T, Buisson R, Yazinski SA, Tan J, Boukhali M, Gagné JP, Poirier GG, Lan L, Haas W, Zou L. Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination. Genes Dev. 2019 01 01; 33(1-2):75-89. PMID: 30567999.
    Citations:    Fields:    Translation:HumansCells
  17. Zou L, Nguyen HD. Getting a Genomic View of DNA Replication Stress. Mol Cell. 2018 10 18; 72(2):201-203. PMID: 30340018.
    Citations:    Fields:    
  18. Teng Y, Yadav T, Duan M, Tan J, Xiang Y, Gao B, Xu J, Liang Z, Liu Y, Nakajima S, Shi Y, Levine AS, Zou L, Lan L. ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB. Nat Commun. 2018 10 08; 9(1):4115. PMID: 30297739.
    Citations:    Fields:    Translation:HumansCells
  19. Nguyen HD, Leong WY, Li W, Reddy PNG, Sullivan JD, Walter MJ, Zou L, Graubert TA. Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes. Cancer Res. 2018 09 15; 78(18):5363-5374. PMID: 30054334.
    Citations:    Fields:    
  20. Zou L. Ataxia Telangiectasia-Mutated and Rad3-Related Inhibition and Topoisomerase I Trapping Create a Synthetic Lethality in Cancer Cells. J Clin Oncol. 2018 06 01; 36(16):1628-1630. PMID: 29369707.
    Citations:    Fields:    
  21. Guarner A, Morris R, Korenjak M, Boukhali M, Zappia MP, Van Rechem C, Whetstine JR, Ramaswamy S, Zou L, Frolov MV, Haas W, Dyson NJ. E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression. Dev Cell. 2017 12 18; 43(6):689-703.e5. PMID: 29233476.
    Citations: 1     Fields:    Translation:AnimalsCells
  22. Kabeche L, Nguyen HD, Buisson R, Zou L. A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation. Science. 2018 01 05; 359(6371):108-114. PMID: 29170278.
    Citations: 5     Fields:    Translation:HumansCells
  23. Ouyang J, Lan L, Zou L. Regulation of DNA break repair by transcription and RNA. Sci China Life Sci. 2017 Oct; 60(10):1081-1086. PMID: 29075944.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  24. Lemaçon D, Jackson J, Quinet A, Brickner JR, Li S, Yazinski S, You Z, Ira G, Zou L, Mosammaparast N, Vindigni A. MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells. Nat Commun. 2017 10 16; 8(1):860. PMID: 29038425.
    Citations: 15     Fields:    Translation:HumansCells
  25. Dubois JC, Yates M, Gaudreau-Lapierre A, Clément G, Cappadocia L, Gaudreau L, Zou L, Maréchal A. A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination. Nucleic Acids Res. 2017 Sep 06; 45(15):8859-8872. PMID: 28666352.
    Citations: 5     Fields:    Translation:HumansCells
  26. Boulay G, Sandoval GJ, Riggi N, Iyer S, Buisson R, Naigles B, Awad ME, Rengarajan S, Volorio A, McBride MJ, Broye LC, Zou L, Stamenkovic I, Kadoch C, Rivera MN. Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain. Cell. 2017 Sep 21; 171(1):163-178.e19. PMID: 28844694.
    Citations: 9     Fields:    Translation:HumansCells
  27. Buisson R, Lawrence MS, Benes CH, Zou L. APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition. Cancer Res. 2017 09 01; 77(17):4567-4578. PMID: 28698210.
    Citations: 6     Fields:    Translation:HumansCells
  28. Okazaki A, Gameiro PA, Christodoulou D, Laviollette L, Schneider M, Chaves F, Stemmer-Rachamimov A, Yazinski SA, Lee R, Stephanopoulos G, Zou L, Iliopoulos O. Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers. J Clin Invest. 2017 May 01; 127(5):1631-1645. PMID: 28346230.
    Citations: 5     Fields:    Translation:HumansAnimals
  29. Xiang Y, Laurent B, Hsu CH, Nachtergaele S, Lu Z, Sheng W, Xu C, Chen H, Ouyang J, Wang S, Ling D, Hsu PH, Zou L, Jambhekar A, He C, Shi Y. RNA m6A methylation regulates the ultraviolet-induced DNA damage response. Nature. 2017 03 23; 543(7646):573-576. PMID: 28297716.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  30. Nguyen HD, Yadav T, Giri S, Saez B, Graubert TA, Zou L. Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1. Mol Cell. 2017 Mar 02; 65(5):832-847.e4. PMID: 28257700.
    Citations: 14     Fields:    Translation:HumansCells
  31. Yazinski SA, Comaills V, Buisson R, Genois MM, Nguyen HD, Ho CK, Todorova Kwan T, Morris R, Lauffer S, Nussenzweig A, Ramaswamy S, Benes CH, Haber DA, Maheswaran S, Birrer MJ, Zou L. ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells. Genes Dev. 2017 02 01; 31(3):318-332. PMID: 28242626.
    Citations: 13     Fields:    Translation:HumansCells
  32. Buisson R, Niraj J, Rodrigue A, Ho CK, Kreuzer J, Foo TK, Hardy EJ, Dellaire G, Haas W, Xia B, Masson JY, Zou L. Coupling of Homologous Recombination and the Checkpoint by ATR. Mol Cell. 2017 Jan 19; 65(2):336-346. PMID: 28089683.
    Citations: 7     Fields:    Translation:HumansCells
  33. Zou L. DNA Replication Checkpoint: New ATR Activator Identified. Curr Biol. 2017 01 09; 27(1):R33-R35. PMID: 28073021.
  34. Zou L. A Zygotic Checkpoint for Unrepaired Lesions. Cell. 2016 12 15; 167(7):1676-1678. PMID: 27984718.
    Citations:    Fields:    Translation:HumansCells
  35. Comaills V, Kabeche L, Morris R, Buisson R, Yu M, Madden MW, LiCausi JA, Boukhali M, Tajima K, Pan S, Aceto N, Sil S, Zheng Y, Sundaresan T, Yae T, Jordan NV, Miyamoto DT, Ting DT, Ramaswamy S, Haas W, Zou L, Haber DA, Maheswaran S. Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition. Cell Rep. 2016 12 06; 17(10):2632-2647. PMID: 27926867.
    Citations: 13     Fields:    Translation:HumansCells
  36. Yazinski SA, Zou L. Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway. Annu Rev Genet. 2016 Nov 23; 50:155-173. PMID: 27617969.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  37. Zou L, Li L. The 2015 Albert Lasker Basic Medical Research Award: An exhilarating journey to the DNA damage checkpoint. Sci China Life Sci. 2016 Jan; 59(1):103-5. PMID: 26668018.
    Citations: 1     Fields:    Translation:HumansCells
  38. Wu CS, Zou L. The SUMO (Small Ubiquitin-like Modifier) Ligase PIAS3 Primes ATR for Checkpoint Activation. J Biol Chem. 2016 Jan 01; 291(1):279-90. PMID: 26565033.
    Citations: 6     Fields:    Translation:HumansCells
  39. Karnitz LM, Zou L. Molecular Pathways: Targeting ATR in Cancer Therapy. Clin Cancer Res. 2015 Nov 01; 21(21):4780-5. PMID: 26362996.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  40. Buisson R, Boisvert JL, Benes CH, Zou L. Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase. Mol Cell. 2015 Sep 17; 59(6):1011-24. PMID: 26365377.
    Citations: 43     Fields:    Translation:HumansCells
  41. Flynn RL, Cox KE, Jeitany M, Wakimoto H, Bryll AR, Ganem NJ, Bersani F, Pineda JR, Suvà ML, Benes CH, Haber DA, Boussin FD, Zou L. Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors. Science. 2015 Jan 16; 347(6219):273-7. PMID: 25593184.
    Citations: 85     Fields:    Translation:HumansCells
  42. Ouyang J, Garner E, Hallet A, Nguyen HD, Rickman KA, Gill G, Smogorzewska A, Zou L. Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance. Mol Cell. 2015 Jan 08; 57(1):108-22. PMID: 25533185.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  43. Maréchal A, Zou L. RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response. Cell Res. 2015 Jan; 25(1):9-23. PMID: 25403473.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  44. Castillo A, Paul A, Sun B, Huang TH, Wang Y, Yazinski SA, Tyler J, Li L, You MJ, Zou L, Yao J, Wang B. The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression. Cell Rep. 2014 Aug 07; 8(3):807-17. PMID: 25066119.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  45. Wu CS, Ouyang J, Mori E, Nguyen HD, Maréchal A, Hallet A, Chen DJ, Zou L. SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway. Genes Dev. 2014 Jul 01; 28(13):1472-84. PMID: 24990965.
    Citations: 13     Fields:    Translation:HumansCells
  46. Manning AL, Yazinski SA, Nicolay B, Bryll A, Zou L, Dyson NJ. Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion. Mol Cell. 2014 Mar 20; 53(6):993-1004. PMID: 24613344.
    Citations: 19     Fields:    Translation:HumansCells
  47. Maréchal A, Zou L. A LARGe surprise links ATR and Rho. Cell Cycle. 2014; 13(23):3627. PMID: 25551359.
    Citations:    Fields:    Translation:HumansCells
  48. Maréchal A, Li JM, Ji XY, Wu CS, Yazinski SA, Nguyen HD, Liu S, Jiménez AE, Jin J, Zou L. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Mol Cell. 2014 Jan 23; 53(2):235-246. PMID: 24332808.
    Citations: 59     Fields:    Translation:HumansCells
  49. Maréchal A, Zou L. DNA damage sensing by the ATM and ATR kinases. Cold Spring Harb Perspect Biol. 2013 Sep 01; 5(9). PMID: 24003211.
    Citations: 147     Fields:    Translation:Cells
  50. Pfäffle HN, Wang M, Gheorghiu L, Ferraiolo N, Greninger P, Borgmann K, Settleman J, Benes CH, Sequist LV, Zou L, Willers H. EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity. Cancer Res. 2013 Oct 15; 73(20):6254-63. PMID: 23966292.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  51. Ogiwara H, Ui A, Shiotani B, Zou L, Yasui A, Kohno T. Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor. Carcinogenesis. 2013 Nov; 34(11):2486-97. PMID: 23825154.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  52. Shiotani B, Nguyen HD, Håkansson P, Maréchal A, Tse A, Tahara H, Zou L. Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1. Cell Rep. 2013 May 30; 3(5):1651-62. PMID: 23684611.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  53. Birkelbach M, Ferraiolo N, Gheorghiu L, Pfäffle HN, Daly B, Ebright MI, Spencer C, O'Hara C, Whetstine JR, Benes CH, Sequist LV, Zou L, Dahm-Daphi J, Kachnic LA, Willers H. Detection of impaired homologous recombination repair in NSCLC cells and tissues. J Thorac Oncol. 2013 Mar; 8(3):279-86. PMID: 23399959.
    Citations: 13     Fields:    Translation:HumansCells
  54. Zou L. Four pillars of the S-phase checkpoint. Genes Dev. 2013 Feb 01; 27(3):227-33. PMID: 23388823.
    Citations: 11     Fields:    Translation:Animals
  55. Liu S, Ho CK, Ouyang J, Zou L. Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2175-80. PMID: 23345434.
    Citations: 18     Fields:    Translation:HumansCells
  56. Liu S, Song N, Zou L. The conserved C terminus of Claspin interacts with Rad9 and promotes rapid activation of Chk1. Cell Cycle. 2012 Jul 15; 11(14):2711-6. PMID: 22732499.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  57. Centore RC, Yazinski SA, Tse A, Zou L. Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response. Mol Cell. 2012 Jun 08; 46(5):625-35. PMID: 22681887.
    Citations: 46     Fields:    Translation:HumansCells
  58. Flynn RL, Chang S, Zou L. RPA and POT1: friends or foes at telomeres? Cell Cycle. 2012 Feb 15; 11(4):652-7. PMID: 22373525.
    Citations: 9     Fields:    Translation:HumansCells
  59. Havens CG, Shobnam N, Guarino E, Centore RC, Zou L, Kearsey SE, Walter JC. Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2. J Biol Chem. 2012 Mar 30; 287(14):11410-21. PMID: 22303007.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  60. Chiba N, Comaills V, Shiotani B, Takahashi F, Shimada T, Tajima K, Winokur D, Hayashida T, Willers H, Brachtel E, Vivanco MD, Haber DA, Zou L, Maheswaran S. Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2760-5. PMID: 21930940.
    Citations: 24     Fields:    Translation:HumansCells
  61. Yanagihara H, Kobayashi J, Tateishi S, Kato A, Matsuura S, Tauchi H, Yamada K, Takezawa J, Sugasawa K, Masutani C, Hanaoka F, Weemaes CM, Mori T, Zou L, Komatsu K. NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol ?-dependent translesion DNA synthesis. Mol Cell. 2011 Sep 02; 43(5):788-97. PMID: 21884979.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  62. Sirbu BM, Lachmayer SJ, Wülfing V, Marten LM, Clarkson KE, Lee LW, Gheorghiu L, Zou L, Powell SN, Dahm-Daphi J, Willers H. ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells. PLoS One. 2011; 6(8):e23053. PMID: 21857991.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  63. Liu S, Shiotani B, Lahiri M, Maréchal A, Tse A, Leung CC, Glover JN, Yang XH, Zou L. ATR autophosphorylation as a molecular switch for checkpoint activation. Mol Cell. 2011 Jul 22; 43(2):192-202. PMID: 21777809.
    Citations: 84     Fields:    Translation:HumansCells
  64. Flynn RL, Centore RC, O'Sullivan RJ, Rai R, Tse A, Songyang Z, Chang S, Karlseder J, Zou L. TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. Nature. 2011 Mar 24; 471(7339):532-6. PMID: 21399625.
    Citations: 119     Fields:    Translation:HumansCells
  65. Nakamura K, Kato A, Kobayashi J, Yanagihara H, Sakamoto S, Oliveira DV, Shimada M, Tauchi H, Suzuki H, Tashiro S, Zou L, Komatsu K. Regulation of homologous recombination by RNF20-dependent H2B ubiquitination. Mol Cell. 2011 Mar 04; 41(5):515-28. PMID: 21362548.
    Citations: 110     Fields:    Translation:HumansCells
  66. Shiotani B, Zou L. A human cell extract-based assay for the activation of ATM and ATR checkpoint kinases. Methods Mol Biol. 2011; 782:181-91. PMID: 21870292.
    Citations: 3     Fields:    Translation:HumansCells
  67. Flynn RL, Zou L. ATR: a master conductor of cellular responses to DNA replication stress. Trends Biochem Sci. 2011 Mar; 36(3):133-40. PMID: 20947357.
    Citations: 86     Fields:    Translation:HumansCells
  68. Centore RC, Havens CG, Manning AL, Li JM, Flynn RL, Tse A, Jin J, Dyson NJ, Walter JC, Zou L. CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. Mol Cell. 2010 Oct 08; 40(1):22-33. PMID: 20932472.
    Citations: 105     Fields:    Translation:HumansAnimalsCells
  69. Zou L. DNA repair: A protein giant in its entirety. Nature. 2010 Oct 07; 467(7316):667-8. PMID: 20930833.
    Citations:    Fields:    Translation:HumansCells
  70. Flynn RL, Zou L. Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians. Crit Rev Biochem Mol Biol. 2010 Aug; 45(4):266-75. PMID: 20515430.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  71. Huang M, Kim JM, Shiotani B, Yang K, Zou L, D'Andrea AD. The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response. Mol Cell. 2010 Jul 30; 39(2):259-68. PMID: 20670894.
    Citations: 53     Fields:    Translation:HumansCells
  72. Sharma SV, Lee DY, Li B, Quinlan MP, Takahashi F, Maheswaran S, McDermott U, Azizian N, Zou L, Fischbach MA, Wong KK, Brandstetter K, Wittner B, Ramaswamy S, Classon M, Settleman J. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell. 2010 Apr 02; 141(1):69-80. PMID: 20371346.
    Citations: 548     Fields:    Translation:HumansCells
  73. Zou L. Checkpoint Mec-tivation comes in many flavors. Mol Cell. 2009 Dec 11; 36(5):734-5. PMID: 20005837.
    Citations: 4     Fields:    Translation:AnimalsCells
  74. Zhang J, Song YH, Brannigan BW, Wahrer DC, Schiripo TA, Harris PL, Haserlat SM, Ulkus LE, Shannon KM, Garber JE, Freedman ML, Henderson BE, Zou L, Sgroi DC, Haber DA, Bell DW. Prevalence and functional analysis of sequence variants in the ATR checkpoint mediator Claspin. Mol Cancer Res. 2009 Sep; 7(9):1510-6. PMID: 19737971.
    Citations: 3     Fields:    Translation:HumansCells
  75. Shiotani B, Zou L. Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks. Mol Cell. 2009 Mar 13; 33(5):547-58. PMID: 19285939.
    Citations: 138     Fields:    Translation:HumansCells
  76. Shiotani B, Zou L. ATR signaling at a glance. J Cell Sci. 2009 Feb 01; 122(Pt 3):301-4. PMID: 19158338.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  77. Yang XH, Zou L. Dual functions of DNA replication forks in checkpoint signaling and PCNA ubiquitination. Cell Cycle. 2009 Jan 15; 8(2):191-4. PMID: 19158510.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  78. Yang XH, Shiotani B, Classon M, Zou L. Chk1 and Claspin potentiate PCNA ubiquitination. Genes Dev. 2008 May 01; 22(9):1147-52. PMID: 18451105.
    Citations: 56     Fields:    Translation:HumansCells
  79. Yang XH, Zou L. Launching a ubiquitination cascade at DNA breaks. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20645-6. PMID: 18093907.
    Citations: 2     Fields:    Translation:HumansCells
  80. Zou L. Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response. Genes Dev. 2007 Apr 15; 21(8):879-85. PMID: 17437994.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  81. Wang X, Zou L, Lu T, Bao S, Hurov KE, Hittelman WN, Elledge SJ, Li L. Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. Mol Cell. 2006 Aug 04; 23(3):331-41. PMID: 16885023.
    Citations: 55     Fields:    Translation:HumansCells
  82. Namiki Y, Zou L. ATRIP associates with replication protein A-coated ssDNA through multiple interactions. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):580-5. PMID: 16407120.
    Citations: 39     Fields:    Translation:HumansCells
  83. Yang XH, Zou L. Recruitment of ATR-ATRIP, Rad17, and 9-1-1 complexes to DNA damage. Methods Enzymol. 2006; 409:118-31. PMID: 16793398.
    Citations: 12     Fields:    Translation:Cells
  84. Yang XH, Zou L. Checkpoint and coordinated cellular responses to DNA damage. Results Probl Cell Differ. 2006; 42:65-92. PMID: 16903208.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  85. Li L, Zou L. Sensing, signaling, and responding to DNA damage: organization of the checkpoint pathways in mammalian cells. J Cell Biochem. 2005 Feb 01; 94(2):298-306. PMID: 15578575.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  86. Zou L, Liu D, Elledge SJ. Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):13827-32. PMID: 14605214.
    Citations: 160     Fields:    Translation:HumansAnimalsCells
  87. Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science. 2003 Jun 06; 300(5625):1542-8. PMID: 12791985.
    Citations: 951     Fields:    Translation:HumansAnimalsCells
  88. Wang X, Zou L, Zheng H, Wei Q, Elledge SJ, Li L. Genomic instability and endoreduplication triggered by RAD17 deletion. Genes Dev. 2003 Apr 15; 17(8):965-70. PMID: 12672690.
    Citations: 25     Fields:    Translation:HumansCells
  89. Osborn AJ, Elledge SJ, Zou L. Checking on the fork: the DNA-replication stress-response pathway. Trends Cell Biol. 2002 Nov; 12(11):509-16. PMID: 12446112.
    Citations: 125     Fields:    Translation:AnimalsCells
  90. Zou L, Cortez D, Elledge SJ. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev. 2002 Jan 15; 16(2):198-208. PMID: 11799063.
    Citations: 182     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.