Harvard Catalyst Profiles

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Lee Zou, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R35CA263934 (ZOU, LEE) Jul 27, 2021 - Jun 30, 2028
    Understanding and targeting the DNA replication stress in cancer cells
    Role: Principal Investigator
  2. R13CA256897 (ZOU, LEE) Jul 1, 2021 - Jun 30, 2022
    2021 Mammalian DNA Repair Gordon Research Conference and Seminar
    Role: Principal Investigator
  3. R01CA248526 (VINDIGNI, ALESSANDRO) Feb 12, 2020 - Jan 31, 2025
    Mechanisms of replication fork protection and recovery
    Role: Co-Principal Investigator
  4. R01CA218856 (ZOU, LEE) May 1, 2018 - Apr 30, 2023
    Impacts of APOBECs on DNA replication, ATR checkpoint, and cancer therapy
    Role: Principal Investigator
  5. R01CA197779 (ZOU, LEE) Jul 1, 2015 - Jun 30, 2025
    Implications of the ATR Checkpoint Kinase in Radiation and Targeted Therapies
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tsujino T, Takai T, Hinohara K, Gui F, Tsutsumi T, Bai X, Miao C, Feng C, Gui B, Sztupinszki Z, Simoneau A, Xie N, Fazli L, Dong X, Azuma H, Choudhury AD, Mouw KW, Szallasi Z, Zou L, Kibel AS, Jia L. CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer. Nat Commun. 2023 Jan 17; 14(1):252. PMID: 36650183; PMCID: PMC9845315.
    Citations:    Fields:    
  2. Yadav T, Zhang JM, Ouyang J, Leung W, Simoneau A, Zou L. TERRA and RAD51AP1 promote alternative lengthening of telomeres through an R- to D-loop switch. Mol Cell. 2022 11 03; 82(21):3985-4000.e4. PMID: 36265486; PMCID: PMC9637728.
    Citations:    Fields:    Translation:Cells
  3. Zhang JM, Zou L. Protocol to stimulate and delineate alternative lengthening of telomeres in human U2OS cells. STAR Protoc. 2022 09 16; 3(3):101594. PMID: 35942347; PMCID: PMC9356160.
    Citations:    Fields:    Translation:HumansCells
  4. Saxena S, Zou L. Hallmarks of DNA replication stress. Mol Cell. 2022 06 16; 82(12):2298-2314. PMID: 35714587; PMCID: PMC9219557.
    Citations:    Fields:    Translation:HumansCells
  5. Yasuhara T, Xing YH, Bauer NC, Lee L, Dong R, Yadav T, Soberman RJ, Rivera MN, Zou L. Condensates induced by transcription inhibition localize active chromatin to nucleoli. Mol Cell. 2022 08 04; 82(15):2738-2753.e6. PMID: 35662392; PMCID: PMC9357099.
    Citations:    Fields:    
  6. Stanzione M, Zhong J, Wong E, LaSalle TJ, Wise JF, Simoneau A, Myers DT, Phat S, Sade-Feldman M, Lawrence MS, Hadden MK, Zou L, Farago AF, Dyson NJ, Drapkin BJ. Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer. Sci Adv. 2022 05 13; 8(19):eabn1229. PMID: 35559669; PMCID: PMC9106301.
    Citations:    Fields:    Translation:HumansCells
  7. Yang H, Wang Y, Xiang Y, Yadav T, Ouyang J, Phoon L, Zhu X, Shi Y, Zou L, Lan L. FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation. Proc Natl Acad Sci U S A. 2022 03 22; 119(12):e2116251119. PMID: 35290126; PMCID: PMC8944906.
    Citations: 2     Fields:    Translation:HumansCells
  8. Hopkins JL, Lan L, Zou L. DNA repair defects in cancer and therapeutic opportunities. Genes Dev. 2022 03 01; 36(5-6):278-293. PMID: 35318271; PMCID: PMC8973847.
    Citations:    Fields:    Translation:HumansCells
  9. Miao C, Tsujino T, Takai T, Gui F, Tsutsumi T, Sztupinszki Z, Wang Z, Azuma H, Szallasi Z, Mouw KW, Zou L, Kibel AS, Jia L. RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer. Sci Adv. 2022 02 18; 8(7):eabl9794. PMID: 35179959; PMCID: PMC8856618.
    Citations: 1     Fields:    Translation:HumansCells
  10. Yasuhara T, Kato R, Yamauchi M, Uchihara Y, Zou L, Miyagawa K, Shibata A. RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair. Cell Rep. 2022 02 01; 38(5):110335. PMID: 35108530.
    Citations:    Fields:    Translation:HumansCells
  11. Krishnan B, Yasuhara T, Rumde P, Stanzione M, Lu C, Lee H, Lawrence MS, Zou L, Nieman LT, Sanidas I, Dyson NJ. Active RB causes visible changes in nuclear organization. J Cell Biol. 2022 03 07; 221(3). PMID: 35019938; PMCID: PMC8759594.
    Citations: 2     Fields:    Translation:HumansCells
  12. Njauw CN, Ji Z, Pham DM, Simoneau A, Kumar R, Flaherty KT, Zou L, Tsao H. Oncogenic KIT Induces Replication Stress and Confers Cell Cycle Checkpoint Vulnerability in Melanoma. J Invest Dermatol. 2022 05; 142(5):1413-1424.e6. PMID: 34687746.
    Citations:    Fields:    Translation:Animals
  13. Kang Z, Fu P, Alcivar AL, Fu H, Redon C, Foo TK, Zuo Y, Ye C, Baxley R, Madireddy A, Buisson R, Bielinsky AK, Zou L, Shen Z, Aladjem MI, Xia B. BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage. Nat Commun. 2021 10 13; 12(1):5966. PMID: 34645815; PMCID: PMC8514439.
    Citations: 5     Fields:    Translation:HumansCells
  14. Tirman S, Quinet A, Wood M, Meroni A, Cybulla E, Jackson J, Pegoraro S, Simoneau A, Zou L, Vindigni A. Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells. Mol Cell. 2021 10 07; 81(19):4026-4040.e8. PMID: 34624216; PMCID: PMC8555837.
    Citations: 10     Fields:    Translation:HumansCells
  15. Guo H, Golczer G, Wittner BS, Langenbucher A, Zachariah M, Dubash TD, Hong X, Comaills V, Burr R, Ebright RY, Horwitz E, Vuille JA, Hajizadeh S, Wiley DF, Reeves BA, Zhang JM, Niederhoffer KL, Lu C, Wesley B, Ho U, Nieman LT, Toner M, Vasudevan S, Zou L, Mostoslavsky R, Maheswaran S, Lawrence MS, Haber DA. NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer. Mol Cell. 2021 10 07; 81(19):4041-4058.e15. PMID: 34624217; PMCID: PMC8549465.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  16. Simoneau A, Xiong R, Zou L. The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells. Genes Dev. 2021 09 01; 35(17-18):1271-1289. PMID: 34385259; PMCID: PMC8415318.
    Citations: 7     Fields:    Translation:Cells
  17. Simoneau A, Zou L. An extending ATR-CHK1 circuitry: the replication stress response and beyond. Curr Opin Genet Dev. 2021 12; 71:92-98. PMID: 34329853.
    Citations: 3     Fields:    Translation:Cells
  18. Yasuhara T, Zou L. Impacts of chromatin dynamics and compartmentalization on DNA repair. DNA Repair (Amst). 2021 09; 105:103162. PMID: 34182258.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  19. Ouyang J, Yadav T, Zhang JM, Yang H, Rheinbay E, Guo H, Haber DA, Lan L, Zou L. RNA transcripts stimulate homologous recombination by forming DR-loops. Nature. 2021 06; 594(7862):283-288. PMID: 33981036; PMCID: PMC8855348.
    Citations: 24     Fields:    Translation:HumansCells
  20. Langenbucher A, Bowen D, Sakhtemani R, Bournique E, Wise JF, Zou L, Bhagwat AS, Buisson R, Lawrence MS. An extended APOBEC3A mutation signature in cancer. Nat Commun. 2021 03 11; 12(1):1602. PMID: 33707442.
    Citations: 16     Fields:    Translation:HumansCells
  21. Al Zubaidi T, Gehrisch OHF, Genois MM, Liu Q, Lu S, Kung J, Xie Y, Schuemann J, Lu HM, Hata AN, Zou L, Borgmann K, Willers H. Targeting the DNA replication stress phenotype of KRAS mutant cancer cells. Sci Rep. 2021 02 11; 11(1):3656. PMID: 33574444; PMCID: PMC7878884.
    Citations: 3     Fields:    Translation:HumansCells
  22. Zhang JM, Genois MM, Ouyang J, Lan L, Zou L. Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies. Mol Cell. 2021 03 04; 81(5):1027-1042.e4. PMID: 33453166; PMCID: PMC8245000.
    Citations: 16     Fields:    Translation:HumansCells
  23. Genois MM, Gagné JP, Yasuhara T, Jackson J, Saxena S, Langelier MF, Ahel I, Bedford MT, Pascal JM, Vindigni A, Poirier GG, Zou L. CARM1 regulates replication fork speed and stress response by stimulating PARP1. Mol Cell. 2021 02 18; 81(4):784-800.e8. PMID: 33412112.
    Citations: 17     Fields:    Translation:HumansCells
  24. Chen H, Chen H, Zhang J, Wang Y, Simoneau A, Yang H, Levine AS, Zou L, Chen Z, Lan L. cGAS suppresses genomic instability as a decelerator of replication forks. Sci Adv. 2020 10; 6(42). PMID: 33055160; PMCID: PMC7556829.
    Citations: 32     Fields:    
  25. Gupta M, Concepcion CP, Fahey CG, Keshishian H, Bhutkar A, Brainson CF, Sanchez-Rivera FJ, Pessina P, Kim JY, Simoneau A, Paschini M, Beytagh MC, Stanclift CR, Schenone M, Mani DR, Li C, Oh A, Li F, Hu H, Karatza A, Bronson RT, Shaw AT, Hata AN, Wong KK, Zou L, Carr SA, Jacks T, Kim CF. BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency. Cancer Res. 2020 09 15; 80(18):3841-3854. PMID: 32690724.
    Citations: 7     Fields:    Translation:HumansAnimals
  26. Matson JP, Zou L. A genome-wide and cotranscriptional suppressor of R loops. Genes Dev. 2020 07 01; 34(13-14):863-864. PMID: 32611612; PMCID: PMC7328514.
    Citations: 2     Fields:    Translation:HumansCells
  27. Vidula N, Dubash T, Lawrence MS, Simoneau A, Niemierko A, Blouch E, Nagy B, Roh W, Chirn B, Reeves BA, Malvarosa G, Lennerz J, Isakoff SJ, Juric D, Micalizzi D, Wander S, Spring L, Moy B, Shannon K, Younger J, Lanman R, Toner M, Iafrate AJ, Getz G, Zou L, Ellisen LW, Maheswaran S, Haber DA, Bardia A. Identification of Somatically Acquired BRCA1/2 Mutations by cfDNA Analysis in Patients with Metastatic Breast Cancer. Clin Cancer Res. 2020 09 15; 26(18):4852-4862. PMID: 32571788.
    Citations: 4     Fields:    Translation:HumansCells
  28. Chen H, Yang H, Zhu X, Yadav T, Ouyang J, Truesdell SS, Tan J, Wang Y, Duan M, Wei L, Zou L, Levine AS, Vasudevan S, Lan L. m5C modification of mRNA serves a DNA damage code to promote homologous recombination. Nat Commun. 2020 06 05; 11(1):2834. PMID: 32503981; PMCID: PMC7275041.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  29. Zhang JM, Zou L. Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks. Cell Biosci. 2020; 10:30. PMID: 32175073; PMCID: PMC7063710.
    Citations: 24     
  30. Tan J, Duan M, Yadav T, Phoon L, Wang X, Zhang JM, Zou L, Lan L. An R-loop-initiated CSB-RAD52-POLD3 pathway suppresses ROS-induced telomeric DNA breaks. Nucleic Acids Res. 2020 02 20; 48(3):1285-1300. PMID: 31777915; PMCID: PMC7026659.
    Citations: 25     Fields:    Translation:HumansCells
  31. Hopkins JL, Zou L. Induction of BRCAness in Triple-Negative Breast Cancer by a CDK12/13 Inhibitor Improves Chemotherapy. Cancer Cell. 2019 11 11; 36(5):461-463. PMID: 31715127.
    Citations: 4     Fields:    Translation:Humans
  32. Matos DA, Zhang JM, Ouyang J, Nguyen HD, Genois MM, Zou L. ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop. Mol Cell. 2020 02 06; 77(3):514-527.e4. PMID: 31708417.
    Citations: 34     Fields:    Translation:HumansCells
  33. Gross KM, Zhou W, Breindel JL, Ouyang J, Jin DX, Sokol ES, Gupta PB, Huber K, Zou L, Kuperwasser C. Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium. Cell Rep. 2019 07 09; 28(2):394-407.e6. PMID: 31291576.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  34. Ning JF, Stanciu M, Humphrey MR, Gorham J, Wakimoto H, Nishihara R, Lees J, Zou L, Martuza RL, Wakimoto H, Rabkin SD. Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma. Nat Commun. 2019 07 02; 10(1):2910. PMID: 31266951; PMCID: PMC6606647.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  35. Buisson R, Langenbucher A, Bowen D, Kwan EE, Benes CH, Zou L, Lawrence MS. Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features. Science. 2019 06 28; 364(6447). PMID: 31249028.
    Citations: 91     Fields:    Translation:HumansCells
  36. Simoneau A, Zou L. Calcium Influx Guards Replication Forks against Exonuclease 1. Mol Cell. 2019 06 20; 74(6):1103-1105. PMID: 31226273.
    Citations: 2     Fields:    Translation:Cells
  37. Parikh AR, He Y, Hong TS, Corcoran RB, Clark JW, Ryan DP, Zou L, Ting DT, Catenacci DV, Chao J, Fakih M, Klempner SJ, Ross JS, Frampton GM, Miller VA, Ali SM, Schrock AB. Analysis of DNA Damage Response Gene Alterations and Tumor Mutational Burden Across 17,486 Tubular Gastrointestinal Carcinomas: Implications for Therapy. Oncologist. 2019 10; 24(10):1340-1347. PMID: 31040255.
    Citations: 34     Fields:    Translation:Humans
  38. Nguyen HD, Zou L, Graubert TA. Targeting R-loop-associated ATR response in myelodysplastic syndrome. Oncotarget. 2019 Apr 05; 10(27):2581-2582. PMID: 31080550; PMCID: PMC6498995.
    Citations: 3     Fields:    
  39. Ge C, Vilfranc CL, Che L, Pandita RK, Hambarde S, Andreassen PR, Niu L, Olowokure O, Shah S, Waltz SE, Zou L, Wang J, Pandita TK, Du C. The BRUCE-ATR Signaling Axis Is Required for Accurate DNA Replication and Suppression of Liver Cancer Development. Hepatology. 2019 06; 69(6):2608-2622. PMID: 30693543.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  40. Moquin DM, Genois MM, Zhang JM, Ouyang J, Yadav T, Buisson R, Yazinski SA, Tan J, Boukhali M, Gagné JP, Poirier GG, Lan L, Haas W, Zou L. Erratum: Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination. Genes Dev. 2019 02 01; 33(3-4):253. PMID: 30709902; PMCID: PMC6362811.
    Citations: 1     Fields:    
  41. Zhang JM, Yadav T, Ouyang J, Lan L, Zou L. Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways. Cell Rep. 2019 01 22; 26(4):955-968.e3. PMID: 30673617.
    Citations: 86     Fields:    Translation:HumansCells
  42. Moquin DM, Genois MM, Zhang JM, Ouyang J, Yadav T, Buisson R, Yazinski SA, Tan J, Boukhali M, Gagné JP, Poirier GG, Lan L, Haas W, Zou L. Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination. Genes Dev. 2019 01 01; 33(1-2):75-89. PMID: 30567999; PMCID: PMC6317314.
    Citations: 8     Fields:    Translation:HumansCells
  43. Zou L, Nguyen HD. Getting a Genomic View of DNA Replication Stress. Mol Cell. 2018 10 18; 72(2):201-203. PMID: 30340018.
    Citations: 1     Fields:    Translation:Cells
  44. Teng Y, Yadav T, Duan M, Tan J, Xiang Y, Gao B, Xu J, Liang Z, Liu Y, Nakajima S, Shi Y, Levine AS, Zou L, Lan L. ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB. Nat Commun. 2018 10 08; 9(1):4115. PMID: 30297739.
    Citations: 49     Fields:    Translation:HumansCells
  45. Nguyen HD, Leong WY, Li W, Reddy PNG, Sullivan JD, Walter MJ, Zou L, Graubert TA. Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes. Cancer Res. 2018 09 15; 78(18):5363-5374. PMID: 30054334; PMCID: PMC6139047.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  46. Zou L. Ataxia Telangiectasia-Mutated and Rad3-Related Inhibition and Topoisomerase I Trapping Create a Synthetic Lethality in Cancer Cells. J Clin Oncol. 2018 06 01; 36(16):1628-1630. PMID: 29369707.
    Citations:    Fields:    Translation:Humans
  47. Guarner A, Morris R, Korenjak M, Boukhali M, Zappia MP, Van Rechem C, Whetstine JR, Ramaswamy S, Zou L, Frolov MV, Haas W, Dyson NJ. E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression. Dev Cell. 2017 12 18; 43(6):689-703.e5. PMID: 29233476; PMCID: PMC5901703.
    Citations: 9     Fields:    Translation:AnimalsCells
  48. Kabeche L, Nguyen HD, Buisson R, Zou L. A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation. Science. 2018 01 05; 359(6371):108-114. PMID: 29170278.
    Citations: 106     Fields:    Translation:HumansCells
  49. Ouyang J, Lan L, Zou L. Regulation of DNA break repair by transcription and RNA. Sci China Life Sci. 2017 Oct; 60(10):1081-1086. PMID: 29075944.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  50. Lemaçon D, Jackson J, Quinet A, Brickner JR, Li S, Yazinski S, You Z, Ira G, Zou L, Mosammaparast N, Vindigni A. MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells. Nat Commun. 2017 10 16; 8(1):860. PMID: 29038425; PMCID: PMC5643552.
    Citations: 155     Fields:    Translation:HumansCells
  51. Dubois JC, Yates M, Gaudreau-Lapierre A, Clément G, Cappadocia L, Gaudreau L, Zou L, Maréchal A. A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination. Nucleic Acids Res. 2017 Sep 06; 45(15):8859-8872. PMID: 28666352; PMCID: PMC5587784.
    Citations: 16     Fields:    Translation:HumansCells
  52. Boulay G, Sandoval GJ, Riggi N, Iyer S, Buisson R, Naigles B, Awad ME, Rengarajan S, Volorio A, McBride MJ, Broye LC, Zou L, Stamenkovic I, Kadoch C, Rivera MN. Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain. Cell. 2017 Sep 21; 171(1):163-178.e19. PMID: 28844694; PMCID: PMC6791823.
    Citations: 138     Fields:    Translation:HumansCells
  53. Buisson R, Lawrence MS, Benes CH, Zou L. APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition. Cancer Res. 2017 09 01; 77(17):4567-4578. PMID: 28698210; PMCID: PMC5609510.
    Citations: 33     Fields:    Translation:HumansCells
  54. Okazaki A, Gameiro PA, Christodoulou D, Laviollette L, Schneider M, Chaves F, Stemmer-Rachamimov A, Yazinski SA, Lee R, Stephanopoulos G, Zou L, Iliopoulos O. Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers. J Clin Invest. 2017 May 01; 127(5):1631-1645. PMID: 28346230; PMCID: PMC5409089.
    Citations: 36     Fields:    Translation:HumansAnimals
  55. Xiang Y, Laurent B, Hsu CH, Nachtergaele S, Lu Z, Sheng W, Xu C, Chen H, Ouyang J, Wang S, Ling D, Hsu PH, Zou L, Jambhekar A, He C, Shi Y. RNA m6A methylation regulates the ultraviolet-induced DNA damage response. Nature. 2017 03 23; 543(7646):573-576. PMID: 28297716.
    Citations: 300     Fields:    Translation:HumansAnimalsCells
  56. Nguyen HD, Yadav T, Giri S, Saez B, Graubert TA, Zou L. Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1. Mol Cell. 2017 Mar 02; 65(5):832-847.e4. PMID: 28257700; PMCID: PMC5507214.
    Citations: 105     Fields:    Translation:HumansCells
  57. Yazinski SA, Comaills V, Buisson R, Genois MM, Nguyen HD, Ho CK, Todorova Kwan T, Morris R, Lauffer S, Nussenzweig A, Ramaswamy S, Benes CH, Haber DA, Maheswaran S, Birrer MJ, Zou L. ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells. Genes Dev. 2017 02 01; 31(3):318-332. PMID: 28242626.
    Citations: 143     Fields:    Translation:HumansCells
  58. Buisson R, Niraj J, Rodrigue A, Ho CK, Kreuzer J, Foo TK, Hardy EJ, Dellaire G, Haas W, Xia B, Masson JY, Zou L. Coupling of Homologous Recombination and the Checkpoint by ATR. Mol Cell. 2017 Jan 19; 65(2):336-346. PMID: 28089683; PMCID: PMC5496772.
    Citations: 68     Fields:    Translation:HumansCells
  59. Zou L. DNA Replication Checkpoint: New ATR Activator Identified. Curr Biol. 2017 01 09; 27(1):R33-R35. PMID: 28073021.
    Citations: 8     Fields:    Translation:HumansCells
  60. Zou L. A Zygotic Checkpoint for Unrepaired Lesions. Cell. 2016 12 15; 167(7):1676-1678. PMID: 27984718.
    Citations:    Fields:    Translation:HumansCells
  61. Comaills V, Kabeche L, Morris R, Buisson R, Yu M, Madden MW, LiCausi JA, Boukhali M, Tajima K, Pan S, Aceto N, Sil S, Zheng Y, Sundaresan T, Yae T, Jordan NV, Miyamoto DT, Ting DT, Ramaswamy S, Haas W, Zou L, Haber DA, Maheswaran S. Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition. Cell Rep. 2016 12 06; 17(10):2632-2647. PMID: 27926867.
    Citations: 46     Fields:    Translation:HumansCells
  62. Yazinski SA, Zou L. Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway. Annu Rev Genet. 2016 Nov 23; 50:155-173. PMID: 27617969.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  63. Zou L, Li L. The 2015 Albert Lasker Basic Medical Research Award: An exhilarating journey to the DNA damage checkpoint. Sci China Life Sci. 2016 Jan; 59(1):103-5. PMID: 26668018.
    Citations: 1     Fields:    Translation:HumansCells
  64. Wu CS, Zou L. The SUMO (Small Ubiquitin-like Modifier) Ligase PIAS3 Primes ATR for Checkpoint Activation. J Biol Chem. 2016 Jan 01; 291(1):279-90. PMID: 26565033.
    Citations: 10     Fields:    Translation:HumansCells
  65. Karnitz LM, Zou L. Molecular Pathways: Targeting ATR in Cancer Therapy. Clin Cancer Res. 2015 Nov 01; 21(21):4780-5. PMID: 26362996; PMCID: PMC4631635.
    Citations: 111     Fields:    Translation:HumansAnimalsCells
  66. Buisson R, Boisvert JL, Benes CH, Zou L. Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase. Mol Cell. 2015 Sep 17; 59(6):1011-24. PMID: 26365377.
    Citations: 133     Fields:    Translation:HumansCells
  67. Flynn RL, Cox KE, Jeitany M, Wakimoto H, Bryll AR, Ganem NJ, Bersani F, Pineda JR, Suvà ML, Benes CH, Haber DA, Boussin FD, Zou L. Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors. Science. 2015 Jan 16; 347(6219):273-7. PMID: 25593184.
    Citations: 199     Fields:    Translation:HumansCells
  68. Ouyang J, Garner E, Hallet A, Nguyen HD, Rickman KA, Gill G, Smogorzewska A, Zou L. Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance. Mol Cell. 2015 Jan 08; 57(1):108-22. PMID: 25533185; PMCID: PMC4289429.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  69. Maréchal A, Zou L. RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response. Cell Res. 2015 Jan; 25(1):9-23. PMID: 25403473; PMCID: PMC4650586.
    Citations: 165     Fields:    Translation:HumansAnimalsCells
  70. Castillo A, Paul A, Sun B, Huang TH, Wang Y, Yazinski SA, Tyler J, Li L, You MJ, Zou L, Yao J, Wang B. The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression. Cell Rep. 2014 Aug 07; 8(3):807-17. PMID: 25066119.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  71. Wu CS, Ouyang J, Mori E, Nguyen HD, Maréchal A, Hallet A, Chen DJ, Zou L. SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway. Genes Dev. 2014 Jul 01; 28(13):1472-84. PMID: 24990965.
    Citations: 27     Fields:    Translation:HumansCells
  72. Manning AL, Yazinski SA, Nicolay B, Bryll A, Zou L, Dyson NJ. Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion. Mol Cell. 2014 Mar 20; 53(6):993-1004. PMID: 24613344.
    Citations: 34     Fields:    Translation:HumansCells
  73. Maréchal A, Zou L. A LARGe surprise links ATR and Rho. Cell Cycle. 2014; 13(23):3627. PMID: 25551359; PMCID: PMC4614118.
    Citations:    Fields:    Translation:HumansCells
  74. Maréchal A, Li JM, Ji XY, Wu CS, Yazinski SA, Nguyen HD, Liu S, Jiménez AE, Jin J, Zou L. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Mol Cell. 2014 Jan 23; 53(2):235-246. PMID: 24332808.
    Citations: 119     Fields:    Translation:HumansCells
  75. Maréchal A, Zou L. DNA damage sensing by the ATM and ATR kinases. Cold Spring Harb Perspect Biol. 2013 Sep 01; 5(9). PMID: 24003211.
    Citations: 504     Fields:    Translation:Cells
  76. Pfäffle HN, Wang M, Gheorghiu L, Ferraiolo N, Greninger P, Borgmann K, Settleman J, Benes CH, Sequist LV, Zou L, Willers H. EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity. Cancer Res. 2013 Oct 15; 73(20):6254-63. PMID: 23966292.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  77. Ogiwara H, Ui A, Shiotani B, Zou L, Yasui A, Kohno T. Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor. Carcinogenesis. 2013 Nov; 34(11):2486-97. PMID: 23825154.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  78. Shiotani B, Nguyen HD, Håkansson P, Maréchal A, Tse A, Tahara H, Zou L. Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1. Cell Rep. 2013 May 30; 3(5):1651-62. PMID: 23684611.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  79. Birkelbach M, Ferraiolo N, Gheorghiu L, Pfäffle HN, Daly B, Ebright MI, Spencer C, O'Hara C, Whetstine JR, Benes CH, Sequist LV, Zou L, Dahm-Daphi J, Kachnic LA, Willers H. Detection of impaired homologous recombination repair in NSCLC cells and tissues. J Thorac Oncol. 2013 Mar; 8(3):279-86. PMID: 23399959.
    Citations: 25     Fields:    Translation:HumansCells
  80. Zou L. Four pillars of the S-phase checkpoint. Genes Dev. 2013 Feb 01; 27(3):227-33. PMID: 23388823; PMCID: PMC3576509.
    Citations: 17     Fields:    Translation:Animals
  81. Liu S, Ho CK, Ouyang J, Zou L. Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2175-80. PMID: 23345434; PMCID: PMC3568365.
    Citations: 35     Fields:    Translation:HumansCells
  82. Liu S, Song N, Zou L. The conserved C terminus of Claspin interacts with Rad9 and promotes rapid activation of Chk1. Cell Cycle. 2012 Jul 15; 11(14):2711-6. PMID: 22732499.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  83. Centore RC, Yazinski SA, Tse A, Zou L. Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response. Mol Cell. 2012 Jun 08; 46(5):625-35. PMID: 22681887.
    Citations: 79     Fields:    Translation:HumansCells
  84. Flynn RL, Chang S, Zou L. RPA and POT1: friends or foes at telomeres? Cell Cycle. 2012 Feb 15; 11(4):652-7. PMID: 22373525; PMCID: PMC3318101.
    Citations: 15     Fields:    Translation:HumansCells
  85. Havens CG, Shobnam N, Guarino E, Centore RC, Zou L, Kearsey SE, Walter JC. Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2. J Biol Chem. 2012 Mar 30; 287(14):11410-21. PMID: 22303007.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  86. Chiba N, Comaills V, Shiotani B, Takahashi F, Shimada T, Tajima K, Winokur D, Hayashida T, Willers H, Brachtel E, Vivanco MD, Haber DA, Zou L, Maheswaran S. Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2760-5. PMID: 21930940; PMCID: PMC3286905.
    Citations: 41     Fields:    Translation:HumansCells
  87. Yanagihara H, Kobayashi J, Tateishi S, Kato A, Matsuura S, Tauchi H, Yamada K, Takezawa J, Sugasawa K, Masutani C, Hanaoka F, Weemaes CM, Mori T, Zou L, Komatsu K. NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol ?-dependent translesion DNA synthesis. Mol Cell. 2011 Sep 02; 43(5):788-97. PMID: 21884979.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  88. Sirbu BM, Lachmayer SJ, Wülfing V, Marten LM, Clarkson KE, Lee LW, Gheorghiu L, Zou L, Powell SN, Dahm-Daphi J, Willers H. ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells. PLoS One. 2011; 6(8):e23053. PMID: 21857991; PMCID: PMC3155521.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  89. Liu S, Shiotani B, Lahiri M, Maréchal A, Tse A, Leung CC, Glover JN, Yang XH, Zou L. ATR autophosphorylation as a molecular switch for checkpoint activation. Mol Cell. 2011 Jul 22; 43(2):192-202. PMID: 21777809; PMCID: PMC3155885.
    Citations: 133     Fields:    Translation:HumansCells
  90. Flynn RL, Centore RC, O'Sullivan RJ, Rai R, Tse A, Songyang Z, Chang S, Karlseder J, Zou L. TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. Nature. 2011 Mar 24; 471(7339):532-6. PMID: 21399625; PMCID: PMC3078637.
    Citations: 180     Fields:    Translation:HumansCells
  91. Nakamura K, Kato A, Kobayashi J, Yanagihara H, Sakamoto S, Oliveira DV, Shimada M, Tauchi H, Suzuki H, Tashiro S, Zou L, Komatsu K. Regulation of homologous recombination by RNF20-dependent H2B ubiquitination. Mol Cell. 2011 Mar 04; 41(5):515-28. PMID: 21362548.
    Citations: 171     Fields:    Translation:HumansCells
  92. Shiotani B, Zou L. A human cell extract-based assay for the activation of ATM and ATR checkpoint kinases. Methods Mol Biol. 2011; 782:181-91. PMID: 21870292.
    Citations: 4     Fields:    Translation:HumansCells
  93. Flynn RL, Zou L. ATR: a master conductor of cellular responses to DNA replication stress. Trends Biochem Sci. 2011 Mar; 36(3):133-40. PMID: 20947357; PMCID: PMC3024454.
    Citations: 139     Fields:    Translation:HumansCells
  94. Centore RC, Havens CG, Manning AL, Li JM, Flynn RL, Tse A, Jin J, Dyson NJ, Walter JC, Zou L. CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. Mol Cell. 2010 Oct 08; 40(1):22-33. PMID: 20932472.
    Citations: 135     Fields:    Translation:HumansAnimalsCells
  95. Zou L. DNA repair: A protein giant in its entirety. Nature. 2010 Oct 07; 467(7316):667-8. PMID: 20930833.
    Citations:    Fields:    Translation:HumansCells
  96. Flynn RL, Zou L. Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians. Crit Rev Biochem Mol Biol. 2010 Aug; 45(4):266-75. PMID: 20515430.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  97. Huang M, Kim JM, Shiotani B, Yang K, Zou L, D'Andrea AD. The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response. Mol Cell. 2010 Jul 30; 39(2):259-68. PMID: 20670894; PMCID: PMC2928996.
    Citations: 77     Fields:    Translation:HumansCells
  98. Sharma SV, Lee DY, Li B, Quinlan MP, Takahashi F, Maheswaran S, McDermott U, Azizian N, Zou L, Fischbach MA, Wong KK, Brandstetter K, Wittner B, Ramaswamy S, Classon M, Settleman J. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell. 2010 Apr 02; 141(1):69-80. PMID: 20371346.
    Citations: 1059     Fields:    Translation:HumansCells
  99. Zou L. Checkpoint Mec-tivation comes in many flavors. Mol Cell. 2009 Dec 11; 36(5):734-5. PMID: 20005837.
    Citations: 4     Fields:    Translation:AnimalsCells
  100. Zhang J, Song YH, Brannigan BW, Wahrer DC, Schiripo TA, Harris PL, Haserlat SM, Ulkus LE, Shannon KM, Garber JE, Freedman ML, Henderson BE, Zou L, Sgroi DC, Haber DA, Bell DW. Prevalence and functional analysis of sequence variants in the ATR checkpoint mediator Claspin. Mol Cancer Res. 2009 Sep; 7(9):1510-6. PMID: 19737971.
    Citations: 4     Fields:    Translation:HumansCells
  101. Shiotani B, Zou L. Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks. Mol Cell. 2009 Mar 13; 33(5):547-58. PMID: 19285939; PMCID: PMC2675165.
    Citations: 199     Fields:    Translation:HumansCells
  102. Shiotani B, Zou L. ATR signaling at a glance. J Cell Sci. 2009 Feb 01; 122(Pt 3):301-4. PMID: 19158338; PMCID: PMC2724726.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  103. Yang XH, Zou L. Dual functions of DNA replication forks in checkpoint signaling and PCNA ubiquitination. Cell Cycle. 2009 Jan 15; 8(2):191-4. PMID: 19158510.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  104. Yang XH, Shiotani B, Classon M, Zou L. Chk1 and Claspin potentiate PCNA ubiquitination. Genes Dev. 2008 May 01; 22(9):1147-52. PMID: 18451105; PMCID: PMC2335311.
    Citations: 65     Fields:    Translation:HumansCells
  105. Yang XH, Zou L. Launching a ubiquitination cascade at DNA breaks. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20645-6. PMID: 18093907.
    Citations: 2     Fields:    Translation:HumansCells
  106. Zou L. Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response. Genes Dev. 2007 Apr 15; 21(8):879-85. PMID: 17437994.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  107. Wang X, Zou L, Lu T, Bao S, Hurov KE, Hittelman WN, Elledge SJ, Li L. Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. Mol Cell. 2006 Aug 04; 23(3):331-41. PMID: 16885023.
    Citations: 64     Fields:    Translation:HumansCells
  108. Namiki Y, Zou L. ATRIP associates with replication protein A-coated ssDNA through multiple interactions. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):580-5. PMID: 16407120; PMCID: PMC1334680.
    Citations: 51     Fields:    Translation:HumansCells
  109. Yang XH, Zou L. Recruitment of ATR-ATRIP, Rad17, and 9-1-1 complexes to DNA damage. Methods Enzymol. 2006; 409:118-31. PMID: 16793398.
    Citations: 18     Fields:    Translation:Cells
  110. Yang XH, Zou L. Checkpoint and coordinated cellular responses to DNA damage. Results Probl Cell Differ. 2006; 42:65-92. PMID: 16903208.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  111. Li L, Zou L. Sensing, signaling, and responding to DNA damage: organization of the checkpoint pathways in mammalian cells. J Cell Biochem. 2005 Feb 01; 94(2):298-306. PMID: 15578575.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  112. Zou L, Liu D, Elledge SJ. Replication protein A-mediated recruitment and activation of Rad17 complexes. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):13827-32. PMID: 14605214; PMCID: PMC283506.
    Citations: 188     Fields:    Translation:HumansAnimalsCells
  113. Zou L, Elledge SJ. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science. 2003 Jun 06; 300(5625):1542-8. PMID: 12791985.
    Citations: 1255     Fields:    Translation:HumansAnimalsCells
  114. Wang X, Zou L, Zheng H, Wei Q, Elledge SJ, Li L. Genomic instability and endoreduplication triggered by RAD17 deletion. Genes Dev. 2003 Apr 15; 17(8):965-70. PMID: 12672690; PMCID: PMC196036.
    Citations: 31     Fields:    Translation:HumansCells
  115. Osborn AJ, Elledge SJ, Zou L. Checking on the fork: the DNA-replication stress-response pathway. Trends Cell Biol. 2002 Nov; 12(11):509-16. PMID: 12446112.
    Citations: 147     Fields:    Translation:AnimalsCells
  116. Zou L, Cortez D, Elledge SJ. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev. 2002 Jan 15; 16(2):198-208. PMID: 11799063; PMCID: PMC155323.
    Citations: 203     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.