Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

David J. Friedman, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01DK130060 (BHALLA, VIVEK) Aug 25, 2021 - Jun 30, 2026
    Discovery Science Collaborative for CKDu
    Role: Co-Principal Investigator
  2. R01MD014726 (FRIEDMAN, DAVID J) Feb 14, 2020 - Dec 31, 2024
    APOL1 Nephropathy: Linking Genetics and Mechanisms
    Role: Principal Investigator
  3. R01DK116021 (BROOKS, DANIEL R) Sep 14, 2018 - Jun 30, 2023
    Role of Genetic Susceptibility in the Central American Kidney Disease Epidemic
    Role: Co-Principal Investigator
  4. R01MD007092 (POLLAK, MARTIN R.) Apr 1, 2012 - Jan 31, 2022
    APOL1 variants: Understanding the basis of disparities in rates of kidney disease
    Role: Co-Principal Investigator
  5. R03DK088006 (FRIEDMAN, DAVID J) Aug 1, 2010 - Jul 31, 2013
    Adenosine signaling protects the glomerular endothelium
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Vandorpe DH, Heneghan JF, Waitzman JS, McCarthy GM, Blasio A, Magraner JM, Donovan OG, Schaller LB, Shah SS, Subramanian B, Riella CV, Friedman DJ, Pollak MR, Alper SL. Apolipoprotein L1 (APOL1) cation current in HEK-293 cells and in human podocytes. Pflugers Arch. 2022 Nov 30. PMID: 36449077.
    Citations:    Fields:    
  2. Raines NH, Inker LA, Seegmiller JC, Brooks DR, Gonzalez-Quiroz M, Friedman DJ. Estimated Versus Measured Glomerular Filtration Rate in Men at Risk for Mesoamerican Nephropathy. Am J Kidney Dis. 2022 Oct 31. PMID: 36328101.
    Citations:    Fields:    
  3. Riella CV, McNulty M, Ribas GT, Tattersfield CF, Perez-Gill C, Eichinger F, Kelly J, Chun J, Subramanian B, Guizelini D, Alper SL, Pollak MR, Sampson MG, Friedman DJ. ADAR regulates APOL1 via A-to-I RNA editing by inhibition of MDA5 activation in a paradoxical biological circuit. Proc Natl Acad Sci U S A. 2022 11; 119(44):e2210150119. PMID: 36282916; PMCID: PMC9636950.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Friedman DJ, Ma L, Freedman BI. Treatment potential in APOL1-associated nephropathy. Curr Opin Nephrol Hypertens. 2022 09 01; 31(5):442-448. PMID: 35894278.
    Citations:    Fields:    Translation:Humans
  5. Chun J, Riella CV, Chung H, Shah SS, Wang M, Magraner JM, Ribas GT, Ribas HT, Zhang JY, Alper SL, Friedman DJ, Pollak MR. DGAT2 Inhibition Potentiates Lipid Droplet Formation To Reduce Cytotoxicity in APOL1 Kidney Risk Variants. J Am Soc Nephrol. 2022 05; 33(5):889-907. PMID: 35232775; PMCID: PMC9063887.
    Citations:    Fields:    Translation:HumansCells
  6. McNulty MT, Fermin D, Eichinger F, Jang D, Kretzler M, Burtt NP, Pollak MR, Flannick J, Weins A, Friedman DJ, Sampson MG. A glomerular transcriptomic landscape of apolipoprotein L1 in Black patients with focal segmental glomerulosclerosis. Kidney Int. 2022 07; 102(1):136-148. PMID: 34929253; PMCID: PMC9206042.
    Citations: 1     Fields:    Translation:HumansCells
  7. McCarthy GM, Blasio A, Donovan OG, Schaller LB, Bock-Hughes A, Magraner JM, Suh JH, Tattersfield CF, Stillman IE, Shah SS, Zsengeller ZK, Subramanian B, Friedman DJ, Pollak MR. Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease. Dis Model Mech. 2021 08 01; 14(8). PMID: 34350953; PMCID: PMC8353097.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  8. Friedman DJ. COVID-19 and APOL1: Understanding Disease Mechanisms through Clinical Observation. J Am Soc Nephrol. 2021 01; 32(1):1-2. PMID: 33288631.
    Citations: 6     Fields:    Translation:HumansCells
  9. Ngo D, Wen D, Gao Y, Keyes MJ, Drury ER, Katz DH, Benson MD, Sinha S, Shen D, Farrell LA, Peterson BD, Friedman DJ, Elmariah S, Young BA, Smith JG, Yang Q, Vasan RS, Larson MG, Correa A, Humphreys BD, Wang TJ, Pollak MR, Wilson JG, Gerszten RE, Rhee EP. Circulating testican-2 is a podocyte-derived marker of kidney health. Proc Natl Acad Sci U S A. 2020 10 06; 117(40):25026-25035. PMID: 32958645; PMCID: PMC7547280.
    Citations: 8     Fields:    Translation:HumansCells
  10. Friedman DJ, Pollak MR. APOL1 Nephropathy: From Genetics to Clinical Applications. Clin J Am Soc Nephrol. 2021 02 08; 16(2):294-303. PMID: 32616495; PMCID: PMC7863644.
    Citations: 22     Fields:    Translation:Humans
  11. Pollak MR, Friedman DJ. The Genetic Architecture of Kidney Disease. Clin J Am Soc Nephrol. 2020 02 07; 15(2):268-275. PMID: 31992573.
    Citations: 5     Fields:    Translation:HumansAnimals
  12. Yih WK, Kulldorff M, Leibler JH, Friedman DJ, Brooks DR. Comment on Sarathkumara et al.: Exposure to Hantavirus is a Risk Factor Associated with Kidney Diseases in Sri Lanka: A Cross Sectional Study. Viruses. 2019 12 11; 11(12). PMID: 31835714.
    Citations:    Fields:    Translation:HumansCells
  13. Drury ER, Friedman DJ, Pollak MR, Ix JH, Kuller LH, Tracy RP, Mukamal KJ. APOL1 gene variants and kidney disease in whites: the cardiovascular health study. Nephrol Dial Transplant. 2019 12 01; 34(12):2155-2156. PMID: 31580460.
    Citations:    Fields:    
  14. Friedman DJ, Pollak MR. APOL1 and Kidney Disease: From Genetics to Biology. Annu Rev Physiol. 2020 02 10; 82:323-342. PMID: 31710572.
    Citations: 33     Fields:    Translation:Humans
  15. Shah SS, Lannon H, Dias L, Zhang JY, Alper SL, Pollak MR, Friedman DJ. APOL1 Kidney Risk Variants Induce Cell Death via Mitochondrial Translocation and Opening of the Mitochondrial Permeability Transition Pore. J Am Soc Nephrol. 2019 12; 30(12):2355-2368. PMID: 31558683; PMCID: PMC6900802.
    Citations: 28     Fields:    Translation:HumansCells
  16. Yih WK, Kulldorff M, Friedman DJ, Leibler JH, Amador JJ, López-Pilarte D, Galloway RL, Ramírez-Rubio O, Riefkohl A, Brooks DR. Investigating Possible Infectious Causes of Chronic Kidney Disease of Unknown Etiology in a Nicaraguan Mining Community. Am J Trop Med Hyg. 2019 09; 101(3):676-683. PMID: 31309920; PMCID: PMC6726956.
    Citations: 7     Fields:    Translation:HumansCellsPHPublic Health
  17. Lannon H, Shah SS, Dias L, Blackler D, Alper SL, Pollak MR, Friedman DJ. Apolipoprotein L1 (APOL1) risk variant toxicity depends on the haplotype background. Kidney Int. 2019 12; 96(6):1303-1307. PMID: 31611067.
    Citations: 18     Fields:    Translation:Humans
  18. Wang M, Chun J, Genovese G, Knob AU, Benjamin A, Wilkins MS, Friedman DJ, Appel GB, Lifton RP, Mane S, Pollak MR. Contributions of Rare Gene Variants to Familial and Sporadic FSGS. J Am Soc Nephrol. 2019 09; 30(9):1625-1640. PMID: 31308072.
    Citations: 16     Fields:    Translation:Humans
  19. Riella C, Siemens TA, Wang M, Campos RP, Moraes TP, Riella LV, Friedman DJ, Riella MC, Pollak MR. APOL1-Associated Kidney Disease in Brazil. Kidney Int Rep. 2019 Jul; 4(7):923-929. PMID: 31317114; PMCID: PMC6611925.
    Citations: 13     
  20. Chun J, Zhang JY, Wilkins MS, Subramanian B, Riella C, Magraner JM, Alper SL, Friedman DJ, Pollak MR. Recruitment of APOL1 kidney disease risk variants to lipid droplets attenuates cell toxicity. Proc Natl Acad Sci U S A. 2019 02 26; 116(9):3712-3721. PMID: 30733285; PMCID: PMC6397558.
    Citations: 28     Fields:    Translation:HumansCells
  21. Friedman DJ. Genes and environment in chronic kidney disease hotspots. Curr Opin Nephrol Hypertens. 2019 01; 28(1):87-96. PMID: 30451737; PMCID: PMC6763202.
    Citations: 3     Fields:    Translation:Humans
  22. Baird JR, Bell RB, Troesch V, Friedman D, Bambina S, Kramer G, Blair TC, Medler T, Wu Y, Sun Z, de Gruijl TD, van de Ven R, Leidner RS, Crittenden MR, Gough MJ. Evaluation of Explant Responses to STING Ligands: Personalized Immunosurgical Therapy for Head and Neck Squamous Cell Carcinoma. Cancer Res. 2018 11 01; 78(21):6308-6319. PMID: 30224374.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  23. Kupferman J, Ramírez-Rubio O, Amador JJ, López-Pilarte D, Wilker EH, Laws RL, Sennett C, Robles NV, Lau JL, Salinas AJ, Kaufman JS, Weiner DE, Scammell MK, McClean MD, Brooks DR, Friedman DJ. Acute Kidney Injury in Sugarcane Workers at Risk for Mesoamerican Nephropathy. Am J Kidney Dis. 2018 10; 72(4):475-482. PMID: 30042041.
    Citations: 26     Fields:    Translation:HumansAnimals
  24. Friedman DJ. Exome Sequencing for CKD Diagnosis: Coming Soon to a Clinic Near You? Am J Kidney Dis. 2018 11; 72(5):761-763. PMID: 29866461.
    Citations:    Fields:    Translation:Humans
  25. Zhang JY, Wang M, Tian L, Genovese G, Yan P, Wilson JG, Thadhani R, Mottl AK, Appel GB, Bick AG, Sampson MG, Alper SL, Friedman DJ, Pollak MR. UBD modifies APOL1-induced kidney disease risk. Proc Natl Acad Sci U S A. 2018 03 27; 115(13):3446-3451. PMID: 29531077; PMCID: PMC5879665.
    Citations: 24     Fields:    Translation:Humans
  26. Friedman DJ, Alper SL. Modulation of tubular solute reuptake in UMOD knockout mice. Am J Physiol Renal Physiol. 2018 08 01; 315(2):F238-F240. PMID: 29513073.
    Citations:    Fields:    Translation:Animals
  27. Skorecki KL, Lee JH, Langefeld CD, Rosset S, Tzur S, Wasser WG, Shemer R, Hawkins GA, Divers J, Parekh RS, Li M, Sampson MG, Kretzler M, Pollak MR, Shah S, Blackler D, Nichols B, Wilmot M, Alper SL, Freedman BI, Friedman DJ. A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy. Nephrol Dial Transplant. 2018 02 01; 33(2):323-330. PMID: 28339911; PMCID: PMC5837424.
    Citations: 14     Fields:    Translation:Humans
  28. Friedman DJ. A Brief History of APOL1: A Gene Evolving. Semin Nephrol. 2017 11; 37(6):508-513. PMID: 29110757.
    Citations: 7     Fields:    Translation:HumansAnimals
  29. Messenheimer DJ, Jensen SM, Afentoulis ME, Wegmann KW, Feng Z, Friedman DJ, Gough MJ, Urba WJ, Fox BA. Timing of PD-1 Blockade Is Critical to Effective Combination Immunotherapy with Anti-OX40. Clin Cancer Res. 2017 Oct 15; 23(20):6165-6177. PMID: 28855348; PMCID: PMC5641261.
    Citations: 106     Fields:    Translation:HumansAnimalsCells
  30. Shukha K, Mueller JL, Chung RT, Curry MP, Friedman DJ, Pollak MR, Berg AH. Most ApoL1 Is Secreted by the Liver. J Am Soc Nephrol. 2017 Apr; 28(4):1079-1083. PMID: 27932478; PMCID: PMC5373451.
    Citations: 26     Fields:    Translation:Humans
  31. Friedman DJ. Successful Treatment of a Red and Black Professional Tattoo in Skin Type VI With a Picosecond Dual-Wavelength, Neodymium-Doped Yttrium Aluminium Garnet Laser. Dermatol Surg. 2016 Sep; 42(9):1121-3. PMID: 27227473.
    Citations: 3     Fields:    Translation:Humans
  32. Kupferman J, Amador JJ, Lynch KE, Laws RL, López-Pilarte D, Ramírez-Rubio O, Kaufman JS, Lau JL, Weiner DE, Robles NV, Verma KP, Scammell MK, McClean MD, Brooks DR, Friedman DJ. Characterization of Mesoamerican Nephropathy in a Kidney Failure Hotspot in Nicaragua. Am J Kidney Dis. 2016 Nov; 68(5):716-725. PMID: 27575010.
    Citations: 21     Fields:    Translation:Humans
  33. Sharma AK, Friedman DJ, Pollak MR, Alper SL. Structural characterization of the C-terminal coiled-coil domains of wild-type and kidney disease-associated mutants of apolipoprotein L1. FEBS J. 2016 05; 283(10):1846-62. PMID: 26945671; PMCID: PMC4879057.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  34. Friedman DJ, Pollak MR. Apolipoprotein L1 and Kidney Disease in African Americans. Trends Endocrinol Metab. 2016 Apr; 27(4):204-215. PMID: 26947522; PMCID: PMC4811340.
    Citations: 42     Fields:    Translation:HumansAnimals
  35. Olabisi OA, Zhang JY, VerPlank L, Zahler N, DiBartolo S, Heneghan JF, Schlöndorff JS, Suh JH, Yan P, Alper SL, Friedman DJ, Pollak MR. APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases. Proc Natl Acad Sci U S A. 2016 Jan 26; 113(4):830-7. PMID: 26699492; PMCID: PMC4743809.
    Citations: 93     Fields:    Translation:HumansCells
  36. Mukamal KJ, Tremaglio J, Friedman DJ, Ix JH, Kuller LH, Tracy RP, Pollak MR. APOL1 Genotype, Kidney and Cardiovascular Disease, and Death in Older Adults. Arterioscler Thromb Vasc Biol. 2016 Feb; 36(2):398-403. PMID: 26634651; PMCID: PMC4732891.
    Citations: 48     Fields:    Translation:Humans
  37. Hawkins GA, Friedman DJ, Lu L, McWilliams DR, Chou JW, Sajuthi S, Divers J, Parekh RS, Li M, Genovese G, Pollack MR, Hicks PJ, Bowden DW, Ma L, Freedman BI, Langefeld CD. Re-Sequencing of the APOL1-APOL4 and MYH9 Gene Regions in African Americans Does Not Identify Additional Risks for CKD Progression. Am J Nephrol. 2015; 42(2):99-106. PMID: 26343748; PMCID: PMC4589514.
    Citations: 7     Fields:    Translation:Humans
  38. Ramírez-Rubio O, Amador JJ, Kaufman JS, Weiner DE, Parikh CR, Khan U, McClean MD, Laws RL, López-Pilarte D, Friedman DJ, Kupferman J, Brooks DR. Urine biomarkers of kidney injury among adolescents in Nicaragua, a region affected by an epidemic of chronic kidney disease of unknown aetiology. Nephrol Dial Transplant. 2016 Mar; 31(3):424-32. PMID: 26311057; PMCID: PMC4762398.
    Citations: 26     Fields:    Translation:Humans
  39. Ruchi R, Genovese G, Lee J, Charoonratana VT, Bernhardy AJ, Alper SL, Kopp JB, Thadhani R, Friedman DJ, Pollak MR. Copy Number Variation at the APOL1 Locus. PLoS One. 2015; 10(5):e0125410. PMID: 25933006.
    Citations: 8     Fields:    Translation:Humans
  40. Todd JN, Poon W, Lyssenko V, Groop L, Nichols B, Wilmot M, Robson S, Enjyoji K, Herman MA, Hu C, Zhang R, Jia W, Ma R, Florez JC, Friedman DJ. Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in mice and humans. J Clin Endocrinol Metab. 2015 May; 100(5):E688-96. PMID: 25719930; PMCID: PMC4422893.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  41. Nichols B, Jog P, Lee JH, Blackler D, Wilmot M, D'Agati V, Markowitz G, Kopp JB, Alper SL, Pollak MR, Friedman DJ. Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1. Kidney Int. 2015 Feb; 87(2):332-42. PMID: 25100047.
    Citations: 160     Fields:    Translation:HumansCells
  42. Thomson R, Genovese G, Canon C, Kovacsics D, Higgins MK, Carrington M, Winkler CA, Kopp J, Rotimi C, Adeyemo A, Doumatey A, Ayodo G, Alper SL, Pollak MR, Friedman DJ, Raper J. Evolution of the primate trypanolytic factor APOL1. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):E2130-9. PMID: 24808134.
    Citations: 116     Fields:    Translation:HumansAnimals
  43. Ito K, Bick AG, Flannick J, Friedman DJ, Genovese G, Parfenov MG, Depalma SR, Gupta N, Gabriel SB, Taylor HA, Fox ER, Newton-Cheh C, Kathiresan S, Hirschhorn JN, Altshuler DM, Pollak MR, Wilson JG, Seidman JG, Seidman C. Increased burden of cardiovascular disease in carriers of APOL1 genetic variants. Circ Res. 2014 Feb 28; 114(5):845-50. PMID: 24379297; PMCID: PMC3982584.
    Citations: 93     Fields:    Translation:Humans
  44. Raper J, Friedman DJ. Parasitology: Molecular one-upmanship. Nature. 2013 Sep 19; 501(7467):322-3. PMID: 24048062.
    Citations: 2     Fields:    Translation:HumansAnimals
  45. Berg AH, Drechsler C, Wenger J, Buccafusca R, Hod T, Kalim S, Ramma W, Parikh SM, Steen H, Friedman DJ, Danziger J, Wanner C, Thadhani R, Karumanchi SA. Carbamylation of serum albumin as a risk factor for mortality in patients with kidney failure. Sci Transl Med. 2013 Mar 06; 5(175):175ra29. PMID: 23467560; PMCID: PMC3697767.
    Citations: 59     Fields:    Translation:Humans
  46. Genovese G, Friedman DJ, Pollak MR. APOL1 variants and kidney disease in people of recent African ancestry. Nat Rev Nephrol. 2013 04; 9(4):240-4. PMID: 23438974.
    Citations: 54     Fields:    Translation:Humans
  47. Zaitlen N, Lindström S, Pasaniuc B, Cornelis M, Genovese G, Pollack S, Barton A, Bickeböller H, Bowden DW, Eyre S, Freedman BI, Friedman DJ, Field JK, Groop L, Haugen A, Heinrich J, Henderson BE, Hicks PJ, Hocking LJ, Kolonel LN, Landi MT, Langefeld CD, Le Marchand L, Meister M, Morgan AW, Raji OY, Risch A, Rosenberger A, Scherf D, Steer S, Walshaw M, Waters KM, Wilson AG, Wordsworth P, Zienolddiny S, Tchetgen ET, Haiman C, Hunter DJ, Plenge RM, Worthington J, Christiani DC, Schaumberg DA, Chasman DI, Altshuler D, Voight B, Kraft P, Patterson N, Price AL. Informed conditioning on clinical covariates increases power in case-control association studies. PLoS Genet. 2012; 8(11):e1003032. PMID: 23144628; PMCID: PMC3493452.
    Citations: 41     Fields:    Translation:Humans
  48. Pasquale LR, Loomis SJ, Kang JH, Yaspan BL, Abdrabou W, Budenz DL, Chen TC, Delbono E, Friedman DS, Gaasterland D, Gaasterland T, Grosskreutz CL, Lee RK, Lichter PR, Liu Y, McCarty CA, Moroi SE, Olson LM, Realini T, Rhee DJ, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Allingham RR, Pericak-Vance MA, Weinreb RN, Zhang K, Hauser MA, Richards JE, Haines JL, Wiggs JL. CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States. Am J Ophthalmol. 2013 Feb; 155(2):342-353.e5. PMID: 23111177; PMCID: PMC3544983.
    Citations: 41     Fields:    Translation:HumansCells
  49. Baskaran M, Perera SA, Nongpiur ME, Tun TA, Park J, Kumar RS, Friedman DS, Aung T. Angle assessment by EyeCam, goniophotography, and gonioscopy. J Glaucoma. 2012 Sep; 21(7):493-7. PMID: 21522021.
    Citations: 7     Fields:    Translation:Humans
  50. Baskaran M, Aung T, Friedman DS, Tun TA, Perera SA. Comparison of EyeCam and anterior segment optical coherence tomography in detecting angle closure. Acta Ophthalmol. 2012 Dec; 90(8):e621-5. PMID: 22938754.
    Citations: 6     Fields:    Translation:Humans
  51. Friedman DJ, Bhatt N, Hayman NS, Nichols BJ, Herman M, Nikolaev N, Danziger J. Impact of activated vitamin D on insulin resistance in nondiabetic chronic kidney disease patients. Clin Endocrinol (Oxf). 2012 Jul; 77(1):56-61. PMID: 21913955.
    Citations: 2     Fields:    Translation:Humans
  52. Wiggs JL, Yaspan BL, Hauser MA, Kang JH, Allingham RR, Olson LM, Abdrabou W, Fan BJ, Wang DY, Brodeur W, Budenz DL, Caprioli J, Crenshaw A, Crooks K, Delbono E, Doheny KF, Friedman DS, Gaasterland D, Gaasterland T, Laurie C, Lee RK, Lichter PR, Loomis S, Liu Y, Medeiros FA, McCarty C, Mirel D, Moroi SE, Musch DC, Realini A, Rozsa FW, Schuman JS, Scott K, Singh K, Stein JD, Trager EH, Vanveldhuisen P, Vollrath D, Wollstein G, Yoneyama S, Zhang K, Weinreb RN, Ernst J, Kellis M, Masuda T, Zack D, Richards JE, Pericak-Vance M, Pasquale LR, Haines JL. Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. PLoS Genet. 2012; 8(4):e1002654. PMID: 22570617.
    Citations: 146     Fields:    Translation:HumansCells
  53. Huggins KN, Mathews TA, Locke JL, Szeliga KT, Friedman DP, Bennett AJ, Jones SR. Effects of early life stress on drinking and serotonin system activity in rhesus macaques: 5-hydroxyindoleacetic acid in cerebrospinal fluid predicts brain tissue levels. Alcohol. 2012 Jun; 46(4):371-6. PMID: 22445804.
    Citations: 10     Fields:    Translation:Animals
  54. Sng CC, Foo LL, Cheng CY, Allen JC, He M, Krishnaswamy G, Nongpiur ME, Friedman DS, Wong TY, Aung T. Determinants of anterior chamber depth: the Singapore Chinese Eye Study. Ophthalmology. 2012 Jun; 119(6):1143-50. PMID: 22420959.
    Citations: 27     Fields:    Translation:Humans
  55. Pollak MR, Genovese G, Friedman DJ. APOL1 and kidney disease. Curr Opin Nephrol Hypertens. 2012 Mar; 21(2):179-82. PMID: 22257798.
    Citations: 30     Fields:    Translation:Humans
  56. Foo LL, Nongpiur ME, Allen JC, Perera SA, Friedman DS, He M, Cheng CY, Wong TY, Aung T. Determinants of angle width in Chinese Singaporeans. Ophthalmology. 2012 Feb; 119(2):278-82. PMID: 22118998.
    Citations: 25     Fields:    Translation:Humans
  57. Corcoran CA, Pierre PJ, Haddad T, Bice C, Suomi SJ, Grant KA, Friedman DP, Bennett AJ. Long-term effects of differential early rearing in rhesus macaques: behavioral reactivity in adulthood. Dev Psychobiol. 2012 Jul; 54(5):546-55. PMID: 22072233.
    Citations: 23     Fields:    Translation:Animals
  58. Kanji Z, Powe CE, Wenger JB, Huang C, Ankers E, Sullivan DA, Collerone G, Powe NR, Tonelli M, Bhan I, Bernhardy AJ, Dibartolo S, Friedman D, Genovese G, Pollak MR, Thadhani R. Genetic variation in APOL1 associates with younger age at hemodialysis initiation. J Am Soc Nephrol. 2011 Nov; 22(11):2091-7. PMID: 21997398.
    Citations: 54     Fields:    Translation:Humans
  59. Kopp JB, Nelson GW, Sampath K, Johnson RC, Genovese G, An P, Friedman D, Briggs W, Dart R, Korbet S, Mokrzycki MH, Kimmel PL, Limou S, Ahuja TS, Berns JS, Fryc J, Simon EE, Smith MC, Trachtman H, Michel DM, Schelling JR, Vlahov D, Pollak M, Winkler CA. APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol. 2011 Nov; 22(11):2129-37. PMID: 21997394; PMCID: PMC3231787.
    Citations: 396     Fields:    Translation:Humans
  60. Friedman DJ, Kozlitina J, Genovese G, Jog P, Pollak MR. Population-based risk assessment of APOL1 on renal disease. J Am Soc Nephrol. 2011 Nov; 22(11):2098-105. PMID: 21997396; PMCID: PMC3231785.
    Citations: 123     Fields:    Translation:Humans
  61. Friedman DJ, Turka LA, Robson SC. There's a goat behind door number 3: from Monty Hall to medicine. J Clin Invest. 2011 Oct; 121(10):3819-21. PMID: 21968106; PMCID: PMC3195486.
    Citations:    Fields:    Translation:HumansCells
  62. Friedman DJ, Pollak MR. Genetics of kidney failure and the evolving story of APOL1. J Clin Invest. 2011 Sep; 121(9):3367-74. PMID: 21881214; PMCID: PMC3163957.
    Citations: 58     Fields:    Translation:Humans
  63. McKean-Cowdin R, Varma R, Cotter SA, Tarczy-Hornoch K, Borchert MS, Lin JH, Wen G, Azen SP, Torres M, Tielsch JM, Friedman DS, Repka MX, Katz J, Ibironke J, Giordano L. Risk factors for astigmatism in preschool children: the multi-ethnic pediatric eye disease and Baltimore pediatric eye disease studies. Ophthalmology. 2011 Oct; 118(10):1974-81. PMID: 21856010; PMCID: PMC3186875.
    Citations: 20     Fields:    Translation:Humans
  64. Borchert MS, Varma R, Cotter SA, Tarczy-Hornoch K, McKean-Cowdin R, Lin JH, Wen G, Azen SP, Torres M, Tielsch JM, Friedman DS, Repka MX, Katz J, Ibironke J, Giordano L. Risk factors for hyperopia and myopia in preschool children the multi-ethnic pediatric eye disease and Baltimore pediatric eye disease studies. Ophthalmology. 2011 Oct; 118(10):1966-73. PMID: 21856013; PMCID: PMC3186878.
    Citations: 31     Fields:    Translation:Humans
  65. Wang FH, Liang YB, Peng XY, Wang JJ, Zhang F, Wei WB, Sun LP, Friedman DS, Wang NL, Wong TY. Risk factors for diabetic retinopathy in a rural Chinese population with type 2 diabetes: the Handan Eye Study. Acta Ophthalmol. 2011 Jun; 89(4):e336-43. PMID: 21371287.
    Citations: 30     Fields:    Translation:Humans
  66. Wang Y, Liang YB, Sun LP, Duan XR, Yuan RZ, Wong TY, Yi P, Friedman DS, Wang NL, Wang JJ. Prevalence and causes of amblyopia in a rural adult population of Chinese the Handan Eye Study. Ophthalmology. 2011 Feb; 118(2):279-83. PMID: 20869774.
    Citations: 17     Fields:    Translation:Humans
  67. Freedman BI, Kopp JB, Langefeld CD, Genovese G, Friedman DJ, Nelson GW, Winkler CA, Bowden DW, Pollak MR. The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans. J Am Soc Nephrol. 2010 Sep; 21(9):1422-6. PMID: 20688934.
    Citations: 144     Fields:    Translation:HumansAnimals
  68. Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, Bowden DW, Langefeld CD, Oleksyk TK, Uscinski Knob AL, Bernhardy AJ, Hicks PJ, Nelson GW, Vanhollebeke B, Winkler CA, Kopp JB, Pays E, Pollak MR. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science. 2010 Aug 13; 329(5993):841-5. PMID: 20647424.
    Citations: 916     Fields:    Translation:HumansAnimals
  69. Cates JM, Friedman DB, Seeley EH, Dupont WD, Schwartz HS, Holt GE, Caprioli RM, Young PP. Proteomic analysis of osteogenic sarcoma: association of tumour necrosis factor with poor prognosis. Int J Exp Pathol. 2010 Aug; 91(4):335-49. PMID: 20353421.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  70. Zheng Y, Wong TY, Mitchell P, Friedman DS, He M, Aung T. Distribution of ocular perfusion pressure and its relationship with open-angle glaucoma: the singapore malay eye study. Invest Ophthalmol Vis Sci. 2010 Jul; 51(7):3399-404. PMID: 20164462.
    Citations: 44     Fields:    Translation:Humans
  71. Peng XY, Wang FH, Liang YB, Wang JJ, Sun LP, Peng Y, Friedman DS, Liew G, Wang NL, Wong TY. Retinopathy in persons without diabetes: the Handan Eye Study. Ophthalmology. 2010 Mar; 117(3):531-7, 537.e1-2. PMID: 20036013.
    Citations: 11     Fields:    Translation:Humans
  72. Friedman D, de Chastelaine M, Nessler D, Malcolm B. Changes in familiarity and recollection across the lifespan: an ERP perspective. Brain Res. 2010 Jan 15; 1310:124-41. PMID: 19914220.
    Citations: 20     Fields:    Translation:Humans
  73. Friedman DJ, Afkarian M, Tamez H, Bhan I, Isakova T, Wolf M, Ankers E, Ye J, Tonelli M, Zoccali C, Kuro-o M, Moe O, Karumanchi SA, Thadhani R. Klotho variants and chronic hemodialysis mortality. J Bone Miner Res. 2009 Nov; 24(11):1847-55. PMID: 19419323; PMCID: PMC2765930.
    Citations: 28     Fields:    Translation:Humans
  74. Friedman DJ, Künzli BM, A-Rahim YI, Sevigny J, Berberat PO, Enjyoji K, Csizmadia E, Friess H, Robson SC. From the Cover: CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease. Proc Natl Acad Sci U S A. 2009 Sep 29; 106(39):16788-93. PMID: 19805374.
    Citations: 143     Fields:    Translation:HumansAnimals
  75. Friedman DS, Repka MX, Katz J, Giordano L, Ibironke J, Hawse P, Tielsch JM. Prevalence of amblyopia and strabismus in white and African American children aged 6 through 71 months the Baltimore Pediatric Eye Disease Study. Ophthalmology. 2009 Nov; 116(11):2128-34.e1-2. PMID: 19762084; PMCID: PMC2783780.
    Citations: 135     Fields:    Translation:Humans
  76. Liang YB, Wong TY, Sun LP, Tao QS, Wang JJ, Yang XH, Xiong Y, Wang NL, Friedman DS. Refractive errors in a rural Chinese adult population the Handan eye study. Ophthalmology. 2009 Nov; 116(11):2119-27. PMID: 19744728.
    Citations: 64     Fields:    Translation:Humans
  77. Liang YB, Friedman DS, Wong TY, Wang FH, Duan XR, Yang XH, Zhou Q, Tao Q, Zhan SY, Sun LP, Wang NL. Rationale, design, methodology, and baseline data of a population-based study in rural China: the Handan Eye Study. Ophthalmic Epidemiol. 2009 Mar-Apr; 16(2):115-27. PMID: 19353400.
    Citations: 30     Fields:    Translation:Humans
  78. Giordano L, Friedman DS, Repka MX, Katz J, Ibironke J, Hawes P, Tielsch JM. Prevalence of refractive error among preschool children in an urban population: the Baltimore Pediatric Eye Disease Study. Ophthalmology. 2009 Apr; 116(4):739-46, 746.e1-4. PMID: 19243832; PMCID: PMC2680482.
    Citations: 59     Fields:    Translation:Humans
  79. Wang FH, Liang YB, Zhang F, Wang JJ, Wei WB, Tao QS, Sun LP, Friedman DS, Wang NL, Wong TY. Prevalence of diabetic retinopathy in rural China: the Handan Eye Study. Ophthalmology. 2009 Mar; 116(3):461-7. PMID: 19168222.
    Citations: 80     Fields:    Translation:Humans
  80. Friedman DJ, Talbert ME, Bowden DW, Freedman BI, Mukanya Y, Enjyoji K, Robson SC. Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal disease. Diabetes. 2009 Apr; 58(4):999-1006. PMID: 19095759; PMCID: PMC2661602.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  81. Duan XR, Liang YB, Friedman DS, Sun LP, Wei WB, Wang JJ, Wang GL, Liu W, Tao QS, Wang NL, Wong TY. Prevalence and associations of epiretinal membranes in a rural Chinese adult population: the Handan Eye Study. Invest Ophthalmol Vis Sci. 2009 May; 50(5):2018-23. PMID: 19074799.
    Citations: 30     Fields:    Translation:Humans
  82. Enjyoji K, Kotani K, Thukral C, Blumel B, Sun X, Wu Y, Imai M, Friedman D, Csizmadia E, Bleibel W, Kahn BB, Robson SC. Deletion of cd39/entpd1 results in hepatic insulin resistance. Diabetes. 2008 Sep; 57(9):2311-20. PMID: 18567823; PMCID: PMC2518482.
    Citations: 52     Fields:    Translation:AnimalsCells
  83. Oppermann M, Friedman DJ, Faulhaber-Walter R, Mizel D, Castrop H, Enjyoji K, Robson SC, Schnermann J. Tubuloglomerular feedback and renin secretion in NTPDase1/CD39-deficient mice. Am J Physiol Renal Physiol. 2008 Apr; 294(4):F965-70. PMID: 18256308.
    Citations: 13     Fields:    Translation:AnimalsCells
  84. Broman AT, Quigley HA, West SK, Katz J, Munoz B, Bandeen-Roche K, Tielsch JM, Friedman DS, Crowston J, Taylor HR, Varma R, Leske MC, Bengtsson B, Heijl A, He M, Foster PJ. Estimating the rate of progressive visual field damage in those with open-angle glaucoma, from cross-sectional data. Invest Ophthalmol Vis Sci. 2008 Jan; 49(1):66-76. PMID: 18172076; PMCID: PMC2246309.
    Citations: 53     Fields:    Translation:Humans
  85. Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 2007 Jun 11; 204(6):1257-65. PMID: 17502665; PMCID: PMC2118603.
    Citations: 975     Fields:    Translation:AnimalsCells
  86. Friedman DJ, Rennke HG, Csizmadia E, Enjyoji K, Robson SC. The vascular ectonucleotidase ENTPD1 is a novel renoprotective factor in diabetic nephropathy. Diabetes. 2007 Sep; 56(9):2371-9. PMID: 17473221.
    Citations: 25     Fields:    Translation:HumansAnimals
  87. Dwyer KM, Deaglio S, Gao W, Friedman D, Strom TB, Robson SC. CD39 and control of cellular immune responses. Purinergic Signal. 2007 Mar; 3(1-2):171-80. PMID: 18404431.
    Citations: 109     Fields:    
  88. Chernova MN, Jiang L, Friedman DJ, Darman RB, Lohi H, Kere J, Vandorpe DH, Alper SL. Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity. J Biol Chem. 2005 Mar 04; 280(9):8564-80. PMID: 15548529.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  89. Aung T, Friedman DS, Chew PT, Ang LP, Gazzard G, Lai YF, Yip L, Lai H, Quigley H, Seah SK. Long-term outcomes in asians after acute primary angle closure. Ophthalmology. 2004 Aug; 111(8):1464-9. PMID: 15288972.
    Citations: 32     Fields:    Translation:Humans
  90. Friedman DS, O'Colmain BJ, Muñoz B, Tomany SC, McCarty C, de Jong PT, Nemesure B, Mitchell P, Kempen J. Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol. 2004 Apr; 122(4):564-72. PMID: 15078675.
    Citations: 1023     Fields:    Translation:Humans
  91. Friedman DS, Wolfs RC, O'Colmain BJ, Klein BE, Taylor HR, West S, Leske MC, Mitchell P, Congdon N, Kempen J. Prevalence of open-angle glaucoma among adults in the United States. Arch Ophthalmol. 2004 Apr; 122(4):532-8. PMID: 15078671; PMCID: PMC2798086.
    Citations: 311     Fields:    Translation:Humans
  92. Congdon N, O'Colmain B, Klaver CC, Klein R, Muñoz B, Friedman DS, Kempen J, Taylor HR, Mitchell P. Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol. 2004 Apr; 122(4):477-85. PMID: 15078664.
    Citations: 855     Fields:    Translation:Humans
  93. Congdon N, Vingerling JR, Klein BE, West S, Friedman DS, Kempen J, O'Colmain B, Wu SY, Taylor HR. Prevalence of cataract and pseudophakia/aphakia among adults in the United States. Arch Ophthalmol. 2004 Apr; 122(4):487-94. PMID: 15078665.
    Citations: 177     Fields:    Translation:Humans
  94. Chernova MN, Stewart AK, Jiang L, Friedman DJ, Kunes YZ, Alper SL. Structure-function relationships of AE2 regulation by Ca(i)(2+)-sensitive stimulators NH(4+) and hypertonicity. Am J Physiol Cell Physiol. 2003 May; 284(5):C1235-46. PMID: 12529246.
    Citations: 14     Fields:    Translation:AnimalsCells
  95. Li CJ, Wang C, Friedman DJ, Pardee AB. Reciprocal modulations between p53 and Tat of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A. 1995 Jun 06; 92(12):5461-4. PMID: 7777531; PMCID: PMC41714.
    Citations: 41     Fields:    Translation:HumansCells
  96. Li CJ, Friedman DJ, Wang C, Metelev V, Pardee AB. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science. 1995 Apr 21; 268(5209):429-31. PMID: 7716549.
    Citations: 171     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.