Harvard Catalyst Profiles

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Peter Sicinski, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA247375 (SICINSKI, PETER) Dec 1, 2019 - Nov 30, 2024
    CDC7 kinase in normal and cancer cells: potential implications for cancer treatment
    Role: Principal Investigator
  2. R01CA239660 (SICINSKI, PETER) Mar 1, 2019 - Feb 29, 2024
    The Function of CDK5 in Metastasis
    Role: Principal Investigator
  3. R01CA236226 (SICINSKI, PETER) Dec 1, 2018 - Nov 30, 2023
    Novel therapeutic approaches with CDK4/6 inhibitors for melanoma treatment
    Role: Principal Investigator
  4. R13CA220573 (SICINSKI, PETER) Jul 1, 2017 - Jun 30, 2018
    2017 Cell Growth and Proliferation Gordon Research Conference & Gordon Research Seminar
    Role: Principal Investigator
  5. R01CA202634 (SICINSKI, PETER) Apr 1, 2016 - Mar 31, 2021
    Novel functions of D-type and E-type cyclins in normal and in cancer cells
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Guo Y, Gabola M, Lattanzio R, Paul C, Pinet V, Tang R, Turali H, Bremond J, Longobardi C, Maurizy C, Da Costa Q, Finetti P, Boissière-Michot F, Rivière B, Lemmers C, Garnier S, Bertucci F, Zlobec I, Chebli K, Tazi J, Azar R, Blanchard JM, Sicinski P, Mamessier E, Lemmers B, Hahne M. Cyclin A2 maintains colon homeostasis and is a prognostic factor in colorectal cancer. J Clin Invest. 2021 02 15; 131(4). PMID: 33332285; PMCID: PMC7880422.
    Citations: 4     Fields:    Translation:Animals
  2. Ponce JM, Coen G, Spitler KM, Dragisic N, Martins I, Hinton A, Mungai M, Tadinada SM, Zhang H, Oudit GY, Song LS, Li N, Sicinski P, Strack S, Abel ED, Mitchell C, Hall DD, Grueter CE. Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics. J Am Heart Assoc. 2020 04 07; 9(7):e014366. PMID: 32248761; PMCID: PMC7428645.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  3. Zheng XF, Acharya SS, Choe KN, Nikhil K, Adelmant G, Satapathy SR, Sharma S, Viccaro K, Rana S, Natarajan A, Sicinski P, Marto JA, Shah K, Chowdhury D. A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1. Nat Commun. 2019 09 18; 10(1):4252. PMID: 31534152.
    Citations: 6     Fields:    Translation:HumansCells
  4. Zhou J, Tien AC, Alberta JA, Ficarro SB, Griveau A, Sun Y, Deshpande JS, Card JD, Morgan-Smith M, Michowski W, Hashizume R, James CD, Ligon KL, Snider WD, Sicinski P, Marto JA, Rowitch DH, Stiles CD. A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2. Cell Rep. 2017 03 28; 18(13):3167-3177. PMID: 28355568; PMCID: PMC5394178.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  5. Martinerie L, Manterola M, Chung SS, Panigrahi SK, Weisbach M, Vasileva A, Geng Y, Sicinski P, Wolgemuth DJ. Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis. PLoS Genet. 2014 Feb; 10(2):e1004165. PMID: 24586195.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  6. Cole AM, Myant K, Reed KR, Ridgway RA, Athineos D, Van den Brink GR, Muncan V, Clevers H, Clarke AR, Sicinski P, Sansom OJ. Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. Cancer Res. 2010 Oct 15; 70(20):8149-58. PMID: 20736363.
    Citations: 50     Fields:    Translation:AnimalsCells
  7. Zeng L, Geng Y, Tretiakova M, Yu X, Sicinski P, Kroll TG. Peroxisome proliferator-activated receptor-delta induces cell proliferation by a cyclin E1-dependent mechanism and is up-regulated in thyroid tumors. Cancer Res. 2008 Aug 15; 68(16):6578-86. PMID: 18701481.
    Citations: 12     Fields:    Translation:HumansCells
  8. Hanashiro K, Kanai M, Geng Y, Sicinski P, Fukasawa K. Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells. Oncogene. 2008 Sep 11; 27(40):5288-302. PMID: 18490919.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  9. Sicinski P, Zacharek S, Kim C. Duality of p27Kip1 function in tumorigenesis. Genes Dev. 2007 Jul 15; 21(14):1703-6. PMID: 17639075.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  10. Ciemerych MA, Sicinski P. Cell cycle in mouse development. Oncogene. 2005 Apr 18; 24(17):2877-98. PMID: 15838522.
    Citations: 54     Fields:    Translation:Animals
  11. Deshpande A, Sicinski P, Hinds PW. Cyclins and cdks in development and cancer: a perspective. Oncogene. 2005 Apr 18; 24(17):2909-15. PMID: 15838524.
    Citations: 168     Fields:    Translation:HumansCells
  12. Carthon BC, Neumann CA, Das M, Pawlyk B, Li T, Geng Y, Sicinski P. Genetic replacement of cyclin D1 function in mouse development by cyclin D2. Mol Cell Biol. 2005 Feb; 25(3):1081-8. PMID: 15657434; PMCID: PMC544006.
    Citations: 29     Fields:    Translation:Animals
  13. Geng Y, Yu Q, Whoriskey W, Dick F, Tsai KY, Ford HL, Biswas DK, Pardee AB, Amati B, Jacks T, Richardson A, Dyson N, Sicinski P. Expression of cyclins E1 and E2 during mouse development and in neoplasia. Proc Natl Acad Sci U S A. 2001 Nov 06; 98(23):13138-43. PMID: 11687642; PMCID: PMC60837.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  14. Yu Q, Geng Y, Sicinski P. Specific protection against breast cancers by cyclin D1 ablation. Nature. 2001 Jun 28; 411(6841):1017-21. PMID: 11429595.
    Citations: 344     Fields:    Translation:HumansAnimalsCells
  15. Geng Y, Yu Q, Sicinska E, Das M, Bronson RT, Sicinski P. Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice. Proc Natl Acad Sci U S A. 2001 Jan 02; 98(1):194-9. PMID: 11134518; PMCID: PMC14567.
    Citations: 53     Fields:    Translation:AnimalsCells
  16. Kim HA, Pomeroy SL, Whoriskey W, Pawlitzky I, Benowitz LI, Sicinski P, Stiles CD, Roberts TM. A developmentally regulated switch directs regenerative growth of Schwann cells through cyclin D1. Neuron. 2000 May; 26(2):405-16. PMID: 10839359.
    Citations: 37     Fields:    Translation:AnimalsCells
  17. Solvason N, Wu WW, Parry D, Mahony D, Lam EW, Glassford J, Klaus GG, Sicinski P, Weinberg R, Liu YJ, Howard M, Lees E. Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development. Int Immunol. 2000 May; 12(5):631-8. PMID: 10784609.
    Citations: 44     Fields:    Translation:AnimalsCells
  18. Lam EW, Glassford J, Banerji L, Thomas NS, Sicinski P, Klaus GG. Cyclin D3 compensates for loss of cyclin D2 in mouse B-lymphocytes activated via the antigen receptor and CD40. J Biol Chem. 2000 Feb 04; 275(5):3479-84. PMID: 10652342.
    Citations: 42     Fields:    Translation:AnimalsCells
  19. Bouchard C, Thieke K, Maier A, Saffrich R, Hanley-Hyde J, Ansorge W, Reed S, Sicinski P, Bartek J, Eilers M. Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27. EMBO J. 1999 Oct 01; 18(19):5321-33. PMID: 10508165; PMCID: PMC1171602.
    Citations: 158     Fields:    Translation:HumansAnimalsCells
  20. Geng Y, Whoriskey W, Park MY, Bronson RT, Medema RH, Li T, Weinberg RA, Sicinski P. Rescue of cyclin D1 deficiency by knockin cyclin E. Cell. 1999 Jun 11; 97(6):767-77. PMID: 10380928.
    Citations: 101     Fields:    Translation:HumansAnimals
  21. Huard JM, Forster CC, Carter ML, Sicinski P, Ross ME. Cerebellar histogenesis is disturbed in mice lacking cyclin D2. Development. 1999 May; 126(9):1927-35. PMID: 10101126.
    Citations: 69     Fields:    Translation:AnimalsCells
  22. Robles AI, Rodriguez-Puebla ML, Glick AB, Trempus C, Hansen L, Sicinski P, Tennant RW, Weinberg RA, Yuspa SH, Conti CJ. Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo. Genes Dev. 1998 Aug 15; 12(16):2469-74. PMID: 9716400; PMCID: PMC317082.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  23. Sicinski P, Weinberg RA. A specific role for cyclin D1 in mammary gland development. J Mammary Gland Biol Neoplasia. 1997 Oct; 2(4):335-42. PMID: 10935021.
    Citations: 22     Fields:    Translation:HumansAnimals
  24. Sicinski P, Donaher JL, Geng Y, Parker SB, Gardner H, Park MY, Robker RL, Richards JS, McGinnis LK, Biggers JD, Eppig JJ, Bronson RT, Elledge SJ, Weinberg RA. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature. 1996 Dec 05; 384(6608):470-4. PMID: 8945475.
    Citations: 207     Fields:    Translation:HumansAnimalsCells
  25. Sicinski P, Donaher JL, Parker SB, Li T, Fazeli A, Gardner H, Haslam SZ, Bronson RT, Elledge SJ, Weinberg RA. Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell. 1995 Aug 25; 82(4):621-30. PMID: 7664341.
    Citations: 324     Fields:    Translation:AnimalsCells
  26. Geng Y, Sicinski P, Gorecki D, Barnard PJ. Developmental and tissue-specific regulation of mouse dystrophin: the embryonic isoform in muscular dystrophy. Neuromuscul Disord. 1991; 1(2):125-33. PMID: 1822783.
    Citations: 6     Fields:    Translation:AnimalsCells
  27. Sicinski P, Geng Y, Ryder-Cook AS, Barnard EA, Darlison MG, Barnard PJ. The molecular basis of muscular dystrophy in the mdx mouse: a point mutation. Science. 1989 Jun 30; 244(4912):1578-80. PMID: 2662404.
    Citations: 429     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.