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Zhanyang Yu, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Pilozzi A, Yu Z, Carreras I, Cormier K, Hartley D, Rogers J, Dedeoglu A, Huang X. A Preliminary Study of Cu Exposure Effects upon Alzheimer's Amyloid Pathology. Biomolecules. 2020 Mar 06; 10(3). PMID: 32155778.
  2. Jiang Y, Lin L, Liu N, Wang Q, Yuan J, Li Y, Chung KK, Guo S, Yu Z, Wang X. FGF21 Protects against Aggravated Blood-Brain Barrier Disruption after Ischemic Focal Stroke in Diabetic db/db Male Mice via Cerebrovascular PPAR? Activation. Int J Mol Sci. 2020 Jan 28; 21(3). PMID: 32012810.
  3. Liu N, Jiang Y, Chung JY, Li Y, Yu Z, Kim JW, Lok JM, Whalen MJ, Wang X. Annexin A2 Deficiency Exacerbates Neuroinflammation and Long-Term Neurological Deficits after Traumatic Brain Injury in Mice. Int J Mol Sci. 2019 Dec 05; 20(24). PMID: 31817350.
  4. Esposito E, Ahn BJ, Shi J, Nakamura Y, Park JH, Mandeville ET, Yu Z, Chan SJ, Desai R, Hayakawa A, Ji X, Lo EH, Hayakawa K. Brain-to-cervical lymph node signaling after stroke. Nat Commun. 2019 11 22; 10(1):5306. PMID: 31757960.
  5. Zhao Q, Zhang F, Yu Z, Guo S, Liu N, Jiang Y, Lo EH, Xu Y, Wang X. HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice. J Neuroinflammation. 2019 May 17; 16(1):103. PMID: 31101061.
  6. Yu Z, Cheng C, Liu Y, Liu N, Lo EH, Wang X. Author Correction: Neuroglobin promotes neurogenesis through Wnt signaling pathway. Cell Death Dis. 2019 Mar 01; 10(3):212. PMID: 30824689.
  7. Zhao Q, Yu Z, Zhang F, Huang L, Xing C, Liu N, Xu Y, Wang X. HDAC3 inhibition prevents oxygen glucose deprivation/reoxygenation-induced transendothelial permeability by elevating PPAR? activity in vitro. J Neurochem. 2019 04; 149(2):298-310. PMID: 30347434.
    Citations:    Fields:    
  8. Jiang Y, Liu N, Wang Q, Yu Z, Lin L, Yuan J, Guo S, Ahn BJ, Wang XJ, Li X, Lo EH, Sun X, Wang X. Endocrine Regulator rFGF21 (Recombinant Human Fibroblast Growth Factor 21) Improves Neurological Outcomes Following Focal Ischemic Stroke of Type 2 Diabetes Mellitus Male Mice. Stroke. 2018 12; 49(12):3039-3049. PMID: 30571410.
    Citations:    Fields:    
  9. Yu Z, Cheng C, Liu Y, Liu N, Lo EH, Wang X. Neuroglobin promotes neurogenesis through Wnt signaling pathway. Cell Death Dis. 2018 09 20; 9(10):945. PMID: 30237546.
    Citations:    Fields:    
  10. Yu Z, Lin L, Jiang Y, Chin I, Wang X, Li X, Lo EH, Wang X. Recombinant FGF21 Protects Against Blood-Brain Barrier Leakage Through Nrf2 Upregulation in Type 2 Diabetes Mice. Mol Neurobiol. 2019 Apr; 56(4):2314-2327. PMID: 30022432.
    Citations:    Fields:    
  11. Li W, Chen Z, Yuan J, Yu Z, Cheng C, Zhao Q, Huang L, Hajjar KA, Chen Z, Lo EH, Dai H, Wang X. Annexin A2 is a Robo4 ligand that modulates ARF6 activation-associated cerebral trans-endothelial permeability. J Cereb Blood Flow Metab. 2019 10; 39(10):2048-2060. PMID: 29786451.
    Citations:    Fields:    
  12. Liu N, Yu Z, Xun Y, Shu P, Yue Y, Yuan S, Jiang Y, Huang Z, Yang X, Feng X, Xiang S, Wang X. Amyloid-ß25-35 Upregulates Endogenous Neuroprotectant Neuroglobin via NF?B Activation in vitro. J Alzheimers Dis. 2018; 64(4):1163-1174. PMID: 30010125.
    Citations:    Fields:    
  13. Cheng C, Yu Z, Zhao S, Liao Z, Xing C, Jiang Y, Yang YG, Whalen MJ, Lo EH, Sun X, Wang X. Thrombospondin-1 Gene Deficiency Worsens the Neurological Outcomes of Traumatic Brain Injury in Mice. Int J Med Sci. 2017; 14(10):927-936. PMID: 28924363.
    Citations:    Fields:    Translation:AnimalsCells
  14. Wang Q, Yuan J, Yu Z, Lin L, Jiang Y, Cao Z, Zhuang P, Whalen MJ, Song B, Wang XJ, Li X, Lo EH, Xu Y, Wang X. FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice. Mol Neurobiol. 2018 Jun; 55(6):4702-4717. PMID: 28712011.
    Citations: 2     Fields:    
  15. Fan X, Jiang Y, Yu Z, Liu Q, Guo S, Sun X, van Leyen K, Ning M, Gao X, Lo EH, Wang X. Annexin A2 Plus Low-Dose Tissue Plasminogen Activator Combination Attenuates Cerebrovascular Dysfunction After Focal Embolic Stroke of Rats. Transl Stroke Res. 2017 12; 8(6):549-559. PMID: 28580536.
    Citations: 2     Fields:    Translation:Animals
  16. Lin L, Wang Q, Qian K, Cao Z, Xiao J, Wang X, Li X, Yu Z. bFGF Protects Against Oxygen Glucose Deprivation/Reoxygenation-Induced Endothelial Monolayer Permeability via S1PR1-Dependent Mechanisms. Mol Neurobiol. 2018 Apr; 55(4):3131-3142. PMID: 28466272.
    Citations:    Fields:    
  17. Zhao S, Yu Z, Liu Y, Bai Y, Jiang Y, van Leyen K, Yang YG, Lok JM, Whalen MJ, Lo EH, Wang X. CD47 deficiency improves neurological outcomes of traumatic brain injury in mice. Neurosci Lett. 2017 03 16; 643:125-130. PMID: 27931776.
    Citations:    Fields:    Translation:Animals
  18. Liu N, Yu Z, Xun Y, Li M, Peng X, Xiao Y, Hu X, Sun Y, Yang M, Gan S, Yuan S, Wang X, Xiang S, Zhang J. TNFAIP1 contributes to the neurotoxicity induced by Aß25-35 in Neuro2a cells. BMC Neurosci. 2016 07 18; 17(1):51. PMID: 27430312.
    Citations:    Fields:    Translation:AnimalsCells
  19. Huang Z, Cheng C, Jiang L, Yu Z, Cao F, Zhong J, Guo Z, Sun X. Intraventricular apolipoprotein ApoJ infusion acts protectively in Traumatic Brain Injury. J Neurochem. 2016 Mar; 136(5):1017-25. PMID: 26670094.
    Citations: 2     Fields:    Translation:Animals
  20. Liu N, Yu Z, Gao X, Song YS, Yuan J, Xun Y, Wang T, Yan F, Yuan S, Zhang J, Xiang S, Lo EH, Wang X. Establishment of Cell-Based Neuroglobin Promoter Reporter Assay for Neuroprotective Compounds Screening. CNS Neurol Disord Drug Targets. 2016; 15(5):629-39. PMID: 26996171.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  21. Jiang Y, Fan X, Yu Z, Liao Z, Wang XS, van Leyen K, Sun X, Lo EH, Wang X. Combination Low-Dose Tissue-Type Plasminogen Activator Plus Annexin A2 for Improving Thrombolytic Stroke Therapy. Front Cell Neurosci. 2015; 9:397. PMID: 26528130.
    Citations: 3     
  22. Jiang Y, Fan X, Yu Z, Cheng C, Wang XS, Lo EH, Sun X, Wang X. Low dose tPA plus annexin A2 combination attenuates tPA delayed treatment-associated hemorrhage and improves recovery in rat embolic focal stroke. Neurosci Lett. 2015 Aug 18; 602:73-8. PMID: 26149229.
    Citations: 5     Fields:    Translation:Animals
  23. Yu Z, Zhang Y, Liu N, Yuan J, Lin L, Zhuge Q, Xiao J, Wang X. Roles of Neuroglobin Binding to Mitochondrial Complex III Subunit Cytochrome c1 in Oxygen-Glucose Deprivation-Induced Neurotoxicity in Primary Neurons. Mol Neurobiol. 2016 07; 53(5):3249-3257. PMID: 26050086.
    Citations: 9     Fields:    Translation:AnimalsCells
  24. Yu Z, Li Z, Liu N, Jizhang Y, McCarthy TJ, Tedford CE, Lo EH, Wang X. Near infrared radiation protects against oxygen-glucose deprivation-induced neurotoxicity by down-regulating neuronal nitric oxide synthase (nNOS) activity in vitro. Metab Brain Dis. 2015 Jun; 30(3):829-37. PMID: 25796222.
    Citations: 4     Fields:    Translation:AnimalsCells
  25. Fan X, Jiang Y, Yu Z, Yuan J, Sun X, Xiang S, Lo EH, Wang X. Combination approaches to attenuate hemorrhagic transformation after tPA thrombolytic therapy in patients with poststroke hyperglycemia/diabetes. Adv Pharmacol. 2014; 71:391-410. PMID: 25307224.
    Citations: 6     Fields:    Translation:HumansAnimals
  26. Yu Z, Liu N, Zhao J, Li Y, McCarthy TJ, Tedford CE, Lo EH, Wang X. Near infrared radiation rescues mitochondrial dysfunction in cortical neurons after oxygen-glucose deprivation. Metab Brain Dis. 2015 Apr; 30(2):491-6. PMID: 24599760.
    Citations: 4     Fields:    Translation:AnimalsCells
  27. Wang X, Fan X, Yu Z, Liao Z, Zhao J, Mandeville E, Guo S, Lo EH, Wang X. Effects of tissue plasminogen activator and annexin A2 combination therapy on long-term neurological outcomes of rat focal embolic stroke. Stroke. 2014 Feb; 45(2):619-22. PMID: 24368559.
    Citations: 9     Fields:    Translation:Animals
  28. Yu Z, Liu N, Li Y, Xu J, Wang X. Neuroglobin overexpression inhibits oxygen-glucose deprivation-induced mitochondrial permeability transition pore opening in primary cultured mouse cortical neurons. Neurobiol Dis. 2013 Aug; 56:95-103. PMID: 23639789.
    Citations: 20     Fields:    Translation:AnimalsCells
  29. Yu Z, Poppe JL, Wang X. Mitochondrial mechanisms of neuroglobin's neuroprotection. Oxid Med Cell Longev. 2013; 2013:756989. PMID: 23634236.
    Citations: 13     Fields:    Translation:HumansCells
  30. Dai H, Yu Z, Fan X, Liu N, Yan M, Chen Z, Lo EH, Hajjar KA, Wang X. Dysfunction of annexin A2 contributes to hyperglycaemia-induced loss of human endothelial cell surface fibrinolytic activity. Thromb Haemost. 2013 Jun; 109(6):1070-8. PMID: 23572070.
    Citations: 4     Fields:    Translation:HumansCells
  31. Liu N, Yu Z, Li Y, Yuan J, Zhang J, Xiang S, Wang X. Transcriptional regulation of mouse neuroglobin gene by cyclic AMP responsive element binding protein (CREB) in N2a cells. Neurosci Lett. 2013 Feb 08; 534:333-7. PMID: 23182882.
    Citations: 9     Fields:    Translation:AnimalsCells
  32. Zhao S, Yu Z, Zhao G, Xing C, Hayakawa K, Whalen MJ, Lok JM, Lo EH, Wang X. Neuroglobin-overexpression reduces traumatic brain lesion size in mice. BMC Neurosci. 2012 Jun 15; 13:67. PMID: 22703519.
    Citations: 11     Fields:    Translation:Animals
  33. Yu Z, Liu N, Liu J, Yang K, Wang X. Neuroglobin, a novel target for endogenous neuroprotection against stroke and neurodegenerative disorders. Int J Mol Sci. 2012; 13(6):6995-7014. PMID: 22837676.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  34. Liu N, Yu Z, Xiang S, Zhao S, Tjärnlund-Wolf A, Xing C, Zhang J, Wang X. Transcriptional regulation mechanisms of hypoxia-induced neuroglobin gene expression. Biochem J. 2012 Apr 01; 443(1):153-64. PMID: 22239089.
    Citations: 14     Fields:    Translation:AnimalsCells
  35. Fan X, Qiu J, Yu Z, Dai H, Singhal AB, Lo EH, Wang X. A rat model of studying tissue-type plasminogen activator thrombolysis in ischemic stroke with diabetes. Stroke. 2012 Feb; 43(2):567-70. PMID: 22052516.
    Citations: 28     Fields:    Translation:Animals
  36. Wei X, Yu Z, Cho KS, Chen H, Malik MT, Chen X, Lo EH, Wang X, Chen DF. Neuroglobin is an endogenous neuroprotectant for retinal ganglion cells against glaucomatous damage. Am J Pathol. 2011 Dec; 179(6):2788-97. PMID: 21967817.
    Citations: 12     Fields:    Translation:AnimalsCells
  37. Walvick RP, Bråtane BT, Henninger N, Sicard KM, Bouley J, Yu Z, Lo E, Wang X, Fisher M. Visualization of clot lysis in a rat embolic stroke model: application to comparative lytic efficacy. Stroke. 2011 Apr; 42(4):1110-5. PMID: 21372305.
    Citations: 10     Fields:    Translation:Animals
  38. Fan X, Yu Z, Liu J, Liu N, Hajjar KA, Furie KL, Lo EH, Wang X. Annexin A2: a tissue plasminogen activator amplifier for thrombolytic stroke therapy. Stroke. 2010 Oct; 41(10 Suppl):S54-8. PMID: 20876506.
    Citations: 15     Fields:    Translation:Animals
  39. Pallast S, Arai K, Pekcec A, Yigitkanli K, Yu Z, Wang X, Lo EH, van Leyen K. Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1157-67. PMID: 20068575.
    Citations: 26     Fields:    Translation:AnimalsCells
  40. Zhu H, Fan X, Yu Z, Liu J, Murata Y, Lu J, Zhao S, Hajjar KA, Lo EH, Wang X. Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1137-46. PMID: 20068577.
    Citations: 40     Fields:    Translation:HumansAnimals
  41. Yu Z, Fan X, Lo EH, Wang X. Neuroprotective roles and mechanisms of neuroglobin. Neurol Res. 2009 Mar; 31(2):122-7. PMID: 19298751.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  42. Liu J, Yu Z, Guo S, Lee SR, Xing C, Zhang C, Gao Y, Nicholls DG, Lo EH, Wang X. Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. J Neurosci Res. 2009 Jan; 87(1):164-70. PMID: 18711728.
    Citations: 42     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.