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Susan M. Dymecki, M.D.,Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21NS106491 (LINDEN, DAVID J.) Sep 1, 2018 - Aug 31, 2020
    NIH/NINDS
    Gene expression underlying serotonin axon regrowth in the adult mammalian brain
    Role: Co-Principal Investigator
  2. R01DA034022 (DYMECKI, SUSAN M.) Apr 15, 2014 - Mar 31, 2019
    NIH/NIDA
    Developmental gene networks of 5HT neurons in addiction, aggression, and anxiety
    Role: Principal Investigator
  3. R21DA036056 (DYMECKI, SUSAN M.) Apr 1, 2014 - Mar 31, 2016
    NIH/NIDA
    Function-specific serotonergic neurons, discrete brain targets, and addiction
    Role: Principal Investigator
  4. R21MH083613 (DYMECKI, SUSAN M) Jul 1, 2008 - Jun 30, 2011
    NIH/NIMH
    Novel tools to study circuit function, development, and periods of vulnerability
    Role: Principal Investigator
  5. R01HD051936 (DYMECKI, SUSAN M.) Sep 1, 2007 - Jun 30, 2013
    NIH/NICHD
    Patterning of Late-acting Germinal Zones in the Vertebrate CNS.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Okaty BW, Commons KG, Dymecki SM. Embracing diversity in the 5-HT neuronal system. Nat Rev Neurosci. 2019 Jul; 20(7):397-424. PMID: 30948838.
    Citations:    
  2. Alekseyenko OV, Chan YB, Okaty BW, Chang Y, Dymecki SM, Kravitz EA. Serotonergic Modulation of Aggression in Drosophila Involves GABAergic and Cholinergic Opposing Pathways. Curr Biol. 2019 Jun 18. PMID: 31231050.
    Citations:    
  3. Lunde A, Okaty BW, Dymecki SM, Glover JC. Molecular Profiling Defines Evolutionarily Conserved Transcription Factor Signatures of Major Vestibulospinal Neuron Groups. eNeuro. 2019 Jan-Feb; 6(1). PMID: 30899776.
    Citations:    
  4. Zhou QG, Nemes AD, Lee D, Ro EJ, Zhang J, Nowacki AS, Dymecki SM, Najm IM, Suh H. Chemogenetic silencing of hippocampal neurons suppresses epileptic neural circuits. J Clin Invest. 2019 Jan 02; 129(1):310-323. PMID: 30507615.
    Citations:    Fields:    
  5. Dosumu-Johnson RT, Cocoran AE, Chang Y, Nattie E, Dymecki SM. Acute perturbation of Pet1-neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery. Elife. 2018 10 23; 7. PMID: 30350781.
    Citations:    Fields:    
  6. Weinhard L, Neniskyte U, Vadisiute A, di Bartolomei G, Aygün N, Riviere L, Zonfrillo F, Dymecki S, Gross C. Sexual dimorphism of microglia and synapses during mouse postnatal development. Dev Neurobiol. 2018 06; 78(6):618-626. PMID: 29239126.
    Citations:    Fields:    Translation:AnimalsCells
  7. Hennessy ML, Corcoran AE, Brust RD, Chang Y, Nattie EE, Dymecki SM. Activity of Tachykinin1-Expressing Pet1 Raphe Neurons Modulates the Respiratory Chemoreflex. J Neurosci. 2017 02 15; 37(7):1807-1819. PMID: 28073937.
    Citations: 4     Fields:    Translation:AnimalsCells
  8. Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, O'Neill TG, Zhuo J, Tsan C, Hoynoski J, Rutlin M, Kus L, Niederkofler V, Watanabe M, Dymecki SM, Nelson SB, Heintz N, Hughes DI, Ginty DD. The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell. 2017 Jan 12; 168(1-2):295-310.e19. PMID: 28041852.
    Citations: 15     Fields:    Translation:AnimalsCells
  9. Niederkofler V, Asher TE, Okaty BW, Rood BD, Narayan A, Hwa LS, Beck SG, Miczek KA, Dymecki SM. Identification of Serotonergic Neuronal Modules that Affect Aggressive Behavior. Cell Rep. 2016 11 15; 17(8):1934-1949. PMID: 27851959.
    Citations: 8     Fields:    Translation:AnimalsCells
  10. Santiago-Sim T, Fang X, Hennessy ML, Nalbach SV, DePalma SR, Lee MS, Greenway SC, McDonough B, Hergenroeder GW, Patek KJ, Colosimo SM, Qualmann KJ, Hagan JP, Milewicz DM, MacRae CA, Dymecki SM, Seidman CE, Seidman JG, Kim DH. THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage. Stroke. 2016 12; 47(12):3005-3013. PMID: 27895300.
    Citations: 4     Fields:    Translation:HumansAnimals
  11. Barrett KT, Dosumu-Johnson RT, Daubenspeck JA, Brust RD, Kreouzis V, Kim JC, Li A, Dymecki SM, Nattie EE. Partial Raphe Dysfunction in Neurotransmission Is Sufficient to Increase Mortality after Anoxic Exposures in Mice at a Critical Period in Postnatal Development. J Neurosci. 2016 Apr 06; 36(14):3943-53. PMID: 27053202.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  12. Britz O, Zhang J, Grossmann KS, Dyck J, Kim JC, Dymecki S, Gosgnach S, Goulding M. Correction: A genetically defined asymmetry underlies the inhibitory control of flexor-extensor locomotor movements. Elife. 2015 Nov 25; 4:e13038. PMID: 26606138.
    Citations: 6     Fields:    
  13. Teissier A, Chemiakine A, Inbar B, Bagchi S, Ray RS, Palmiter RD, Dymecki SM, Moore H, Ansorge MS. Activity of Raphé Serotonergic Neurons Controls Emotional Behaviors. Cell Rep. 2015 Dec 01; 13(9):1965-76. PMID: 26655908.
    Citations: 20     Fields:    Translation:AnimalsCells
  14. Okaty BW, Freret ME, Rood BD, Brust RD, Hennessy ML, deBairos D, Kim JC, Cook MN, Dymecki SM. Multi-Scale Molecular Deconstruction of the Serotonin Neuron System. Neuron. 2015 Nov 18; 88(4):774-91. PMID: 26549332.
    Citations: 35     Fields:    Translation:AnimalsCells
  15. Britz O, Zhang J, Grossmann KS, Dyck J, Kim JC, Dymecki S, Gosgnach S, Goulding M. A genetically defined asymmetry underlies the inhibitory control of flexor-extensor locomotor movements. Elife. 2015 Oct 14; 4. PMID: 26465208.
    Citations: 9     Fields:    Translation:AnimalsCells
  16. Hatzistergos KE, Takeuchi LM, Saur D, Seidler B, Dymecki SM, Mai JJ, White IA, Balkan W, Kanashiro-Takeuchi RM, Schally AV, Hare JM. cKit+ cardiac progenitors of neural crest origin. Proc Natl Acad Sci U S A. 2015 Oct 20; 112(42):13051-6. PMID: 26438843.
    Citations: 33     Fields:    Translation:AnimalsCells
  17. Niederkofler V, Asher TE, Dymecki SM. Functional Interplay between Dopaminergic and Serotonergic Neuronal Systems during Development and Adulthood. ACS Chem Neurosci. 2015 Jul 15; 6(7):1055-1070. PMID: 25747116.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  18. Brust RD, Corcoran AE, Richerson GB, Nattie E, Dymecki SM. Functional and developmental identification of a molecular subtype of brain serotonergic neuron specialized to regulate breathing dynamics. Cell Rep. 2014 Dec 24; 9(6):2152-65. PMID: 25497093.
    Citations: 31     Fields:    Translation:AnimalsCells
  19. Espinosa-Medina I, Outin E, Picard CA, Chettouh Z, Dymecki S, Consalez GG, Coppola E, Brunet JF. Neurodevelopment. Parasympathetic ganglia derive from Schwann cell precursors. Science. 2014 Jul 04; 345(6192):87-90. PMID: 24925912.
    Citations: 38     Fields:    Translation:AnimalsCells
  20. Jensen P, Dymecki SM. Essentials of recombinase-based genetic fate mapping in mice. Methods Mol Biol. 2014; 1092:437-54. PMID: 24318835.
    Citations: 12     Fields:    Translation:Animals
  21. Lehtinen MK, Bjornsson CS, Dymecki SM, Gilbertson RJ, Holtzman DM, Monuki ES. The choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy. J Neurosci. 2013 Nov 06; 33(45):17553-9. PMID: 24198345.
    Citations: 29     Fields:    Translation:Humans
  22. Heimer-McGinn V, Murphy AC, Kim JC, Dymecki SM, Young PW. Decreased dendritic spine density as a consequence of tetanus toxin light chain expression in single neurons in vivo. Neurosci Lett. 2013 Oct 25; 555:36-41. PMID: 24035894.
    Citations: 4     Fields:    Translation:AnimalsCells
  23. Massey CA, Kim G, Corcoran AE, Haynes RL, Paterson DS, Cummings KJ, Dymecki SM, Richerson GB, Nattie EE, Kinney HC, Commons KG. Development of brainstem 5-HT1A receptor-binding sites in serotonin-deficient mice. J Neurochem. 2013 Sep; 126(6):749-57. PMID: 23692315.
    Citations: 4     Fields:    Translation:AnimalsCells
  24. Hirsch MR, d'Autréaux F, Dymecki SM, Brunet JF, Goridis C. A Phox2b::FLPo transgenic mouse line suitable for intersectional genetics. Genesis. 2013 Jul; 51(7):506-14. PMID: 23592597.
    Citations: 13     Fields:    Translation:AnimalsCells
  25. Ray RS, Corcoran AE, Brust RD, Soriano LP, Nattie EE, Dymecki SM. Egr2-neurons control the adult respiratory response to hypercapnia. Brain Res. 2013 May 20; 1511:115-25. PMID: 23261662.
    Citations: 8     Fields:    Translation:AnimalsCells
  26. Engleka KA, Manderfield LJ, Brust RD, Li L, Cohen A, Dymecki SM, Epstein JA. Islet1 derivatives in the heart are of both neural crest and second heart field origin. Circ Res. 2012 Mar 30; 110(7):922-6. PMID: 22394517.
    Citations: 36     Fields:    Translation:AnimalsCells
  27. Bang SJ, Jensen P, Dymecki SM, Commons KG. Projections and interconnections of genetically defined serotonin neurons in mice. Eur J Neurosci. 2012 Jan; 35(1):85-96. PMID: 22151329.
    Citations: 51     Fields:    Translation:AnimalsCells
  28. Ray RS, Corcoran AE, Brust RD, Kim JC, Richerson GB, Nattie E, Dymecki SM. Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition. Science. 2011 Jul 29; 333(6042):637-42. PMID: 21798952.
    Citations: 124     Fields:    Translation:AnimalsCells
  29. Nielsen CM, Dymecki SM. Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus. Dev Biol. 2010 Apr 15; 340(2):430-7. PMID: 20123094.
    Citations: 23     Fields:    Translation:AnimalsCells
  30. Dymecki SM, Ray RS, Kim JC. Mapping cell fate and function using recombinase-based intersectional strategies. Methods Enzymol. 2010; 477:183-213. PMID: 20699143.
    Citations: 45     Fields:    Translation:Animals
  31. Ray RS, Dymecki SM. Rautenlippe Redux -- toward a unified view of the precerebellar rhombic lip. Curr Opin Cell Biol. 2009 Dec; 21(6):741-7. PMID: 19883998.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  32. Kim JC, Cook MN, Carey MR, Shen C, Regehr WG, Dymecki SM. Linking genetically defined neurons to behavior through a broadly applicable silencing allele. Neuron. 2009 Aug 13; 63(3):305-15. PMID: 19679071.
    Citations: 46     Fields:    Translation:AnimalsCells
  33. Dipietrantonio HJ, Dymecki SM. Zic1 levels regulate mossy fiber neuron position and axon laterality choice in the ventral brain stem. Neuroscience. 2009 Sep 01; 162(3):560-73. PMID: 19303920.
    Citations: 7     Fields:    Translation:AnimalsCells
  34. Kim JC, Dymecki SM. Genetic fate-mapping approaches: new means to explore the embryonic origins of the cochlear nucleus. Methods Mol Biol. 2009; 493:65-85. PMID: 18839342.
    Citations: 10     Fields:    Translation:Animals
  35. Kinney HC, Richerson GB, Dymecki SM, Darnall RA, Nattie EE. The brainstem and serotonin in the sudden infant death syndrome. Annu Rev Pathol. 2009; 4:517-50. PMID: 19400695.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  36. Kan L, Liu Y, McGuire TL, Berger DM, Awatramani RB, Dymecki SM, Kessler JA. Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification. Stem Cells. 2009 Jan; 27(1):150-6. PMID: 18832590.
    Citations: 40     Fields:    Translation:AnimalsCells
  37. Jensen P, Farago AF, Awatramani RB, Scott MM, Deneris ES, Dymecki SM. Redefining the serotonergic system by genetic lineage. Nat Neurosci. 2008 Apr; 11(4):417-9. PMID: 18344997.
    Citations: 94     Fields:    Translation:AnimalsCells
  38. Hunter NL, Dymecki SM. Molecularly and temporally separable lineages form the hindbrain roof plate and contribute differentially to the choroid plexus. Development. 2007 Oct; 134(19):3449-60. PMID: 17728348.
    Citations: 25     Fields:    Translation:AnimalsCells
  39. Dymecki SM, Kim JC. Molecular neuroanatomy's "Three Gs": a primer. Neuron. 2007 Apr 05; 54(1):17-34. PMID: 17408575.
    Citations: 45     Fields:    Translation:Animals
  40. Farago AF, Awatramani RB, Dymecki SM. Assembly of the brainstem cochlear nuclear complex is revealed by intersectional and subtractive genetic fate maps. Neuron. 2006 Apr 20; 50(2):205-18. PMID: 16630833.
    Citations: 76     Fields:    Translation:AnimalsCells
  41. Hunter NL, Hikasa H, Dymecki SM, Sokol SY. Vertebrate homologues of Frodo are dynamically expressed during embryonic development in tissues undergoing extensive morphogenetic movements. Dev Dyn. 2006 Jan; 235(1):279-84. PMID: 16278878.
    Citations: 3     Fields:    Translation:AnimalsCells
  42. Landsberg RL, Awatramani RB, Hunter NL, Farago AF, DiPietrantonio HJ, Rodriguez CI, Dymecki SM. Hindbrain rhombic lip is comprised of discrete progenitor cell populations allocated by Pax6. Neuron. 2005 Dec 22; 48(6):933-47. PMID: 16364898.
    Citations: 49     Fields:    Translation:AnimalsCells
  43. Hunter NL, Awatramani RB, Farley FW, Dymecki SM. Ligand-activated Flpe for temporally regulated gene modifications. Genesis. 2005 Mar; 41(3):99-109. PMID: 15729687.
    Citations: 18     Fields:    Translation:AnimalsCells
  44. Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, Koller BH, Lloyd KC, Magnuson T, Moore MW, Nagy A, Pollock JD, Roses AD, Sands AT, Seed B, Skarnes WC, Snoddy J, Soriano P, Stewart DJ, Stewart F, Stillman B, Varmus H, Varticovski L, Verma IM, Vogt TF, von Melchner H, Witkowski J, Woychik RP, Wurst W, Yancopoulos GD, Young SG, Zambrowicz B. The knockout mouse project. Nat Genet. 2004 Sep; 36(9):921-4. PMID: 15340423.
    Citations: 196     Fields:    Translation:Animals
  45. Branda CS, Dymecki SM. Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice. Dev Cell. 2004 Jan; 6(1):7-28. PMID: 14723844.
    Citations: 266     Fields:    Translation:Animals
  46. Awatramani R, Soriano P, Rodriguez C, Mai JJ, Dymecki SM. Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation. Nat Genet. 2003 Sep; 35(1):70-5. PMID: 12923530.
    Citations: 68     Fields:    Translation:AnimalsCells
  47. Dymecki SM, Rodriguez CI, Awatramani RB. Switching on lineage tracers using site-specific recombination. Methods Mol Biol. 2002; 185:309-34. PMID: 11768998.
    Citations: 3     Fields:    Translation:AnimalsCells
  48. Awatramani R, Soriano P, Mai JJ, Dymecki S. An Flp indicator mouse expressing alkaline phosphatase from the ROSA26 locus. Nat Genet. 2001 Nov; 29(3):257-9. PMID: 11687793.
    Citations: 20     Fields:    Translation:HumansAnimals
  49. Farley FW, Soriano P, Steffen LS, Dymecki SM. Widespread recombinase expression using FLPeR (flipper) mice. Genesis. 2000 Nov-Dec; 28(3-4):106-10. PMID: 11105051.
    Citations: 260     Fields:    Translation:Animals
  50. Rodriguez CI, Dymecki SM. Origin of the precerebellar system. Neuron. 2000 Sep; 27(3):475-86. PMID: 11055431.
    Citations: 31     Fields:    Translation:AnimalsCells
  51. Rodríguez CI, Buchholz F, Galloway J, Sequerra R, Kasper J, Ayala R, Stewart AF, Dymecki SM. High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet. 2000 Jun; 25(2):139-40. PMID: 10835623.
    Citations: 434     Fields:    Translation:Animals
  52. Baur ST, Mai JJ, Dymecki SM. Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity. Development. 2000 Feb; 127(3):605-19. PMID: 10631181.
    Citations: 43     Fields:    Translation:AnimalsCells
  53. Dymecki SM, Tomasiewicz H. Using Flp-recombinase to characterize expansion of Wnt1-expressing neural progenitors in the mouse. Dev Biol. 1998 Sep 01; 201(1):57-65. PMID: 9733573.
    Citations: 32     Fields:    Translation:AnimalsCells
  54. Dymecki SM. Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12):6191-6. PMID: 8650242.
    Citations: 90     Fields:    Translation:AnimalsCells
  55. Dymecki SM. A modular set of Flp, FRT and lacZ fusion vectors for manipulating genes by site-specific recombination. Gene. 1996 Jun 01; 171(2):197-201. PMID: 8666272.
    Citations: 22     Fields:    Translation:AnimalsCells
  56. Klages S, Adam D, Eiseman E, Fargnoli J, Dymecki SM, Desiderio SV, Bolen JB. Molecular cloning and analysis of cDNA encoding the murine c-yes tyrosine protein kinase. Oncogene. 1993 Mar; 8(3):713-9. PMID: 8437854.
    Citations: 2     Fields:    Translation:AnimalsCells
  57. Dymecki SM, Zwollo P, Zeller K, Kuhajda FP, Desiderio SV. Structure and developmental regulation of the B-lymphoid tyrosine kinase gene blk. J Biol Chem. 1992 Mar 05; 267(7):4815-23. PMID: 1537861.
    Citations: 19     Fields:    Translation:AnimalsCells
  58. Wilson RB, Kiledjian M, Shen CP, Benezra R, Zwollo P, Dymecki SM, Desiderio SV, Kadesch T. Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development. Mol Cell Biol. 1991 Dec; 11(12):6185-91. PMID: 1944284.
    Citations: 50     Fields:    Translation:AnimalsCells
  59. Kozak CA, Dymecki SM, Niederhuber JE, Desiderio SV. Genetic mapping of the gene for a novel tyrosine kinase, Blk, to mouse chromosome 14. Genomics. 1991 Apr; 9(4):762-4. PMID: 2037301.
    Citations: 2     Fields:    Translation:AnimalsCells
  60. Dymecki SM, Niederhuber JE, Desiderio SV. Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. Science. 1990 Jan 19; 247(4940):332-6. PMID: 2404338.
    Citations: 64     Fields:    Translation:AnimalsCells
  61. Dymecki SM, Black J, Nord DS, Jones SB, Baranowski TJ, Brighton CT. Medullary osteogenesis with platinum cathodes. J Orthop Res. 1985; 3(2):125-36. PMID: 3998890.
    Citations:    Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.