Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Francisco Javier Quintana, Ph.D.

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Overview
overview
The Quintana lab is focused on the characterization of signaling pathways that control the activity of the immune system, with the ultimate goal of identifying novel therapeutic targets and biomarkers for immune-mediated disorders. To this aim, we use genomic and proteomic tools to the study zebrafish, murine and human disease models of inflammation
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Mentoring
current student opportunities
Available: 01/01/21, Expires: 12/31/26

Multiple projects are available to investigate mechanisms of inflammation and neurodegeneration in multiple neurologic diseases, and their regulation by metabolism, the gut flora and environmental factors. Our lab uses advanced genomic tools in combination with animal models (mice and zebrafish) and clinical samples. Experience in animal models, cell culture and/or genomics is required.


Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sanmarco LM, Wheeler MA, Gutiérrez-Vázquez C, Polonio CM, Linnerbauer M, Pinho-Ribeiro FA, Li Z, Giovannoni F, Batterman KV, Scalisi G, Zandee SEJ, Heck ES, Alsuwailm M, Rosene DL, Becher B, Chiu IM, Prat A, Quintana FJ. Gut-licensed IFN?+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes. Nature. 2021 Jan 06. PMID: 33408417.
    Citations:    
  2. Rothhammer V, Kenison JE, Li Z, Tjon E, Takenaka MC, Chao CC, Alves de Lima K, Borucki DM, Kaye J, Quintana FJ. Aryl Hydrocarbon Receptor Activation in Astrocytes by Laquinimod Ameliorates Autoimmune Inflammation in the CNS. Neurol Neuroimmunol Neuroinflamm. 2021 Mar 04; 8(2). PMID: 33408169.
    Citations:    
  3. Barroso A, Mahler JV, Fonseca-Castro PH, Quintana FJ. The aryl hydrocarbon receptor and the gut-brain axis. Cell Mol Immunol. 2021 Jan 06. PMID: 33408340.
    Citations:    
  4. Levy O, Rothhammer V, Mascanfroni I, Tong Z, Kuai R, De Biasio M, Wang Q, Majid T, Perrault C, Yeste A, Kenison JE, Safaee H, Musabeyezu J, Heinelt M, Milton Y, Kuang H, Lan H, Siders W, Multon MC, Rothblatt J, Massadeh S, Alaamery M, Alhasan AH, Quintana FJ, Karp JM. A cell-based drug delivery platform for treating central nervous system inflammation. J Mol Med (Berl). 2021 Jan 04. PMID: 33398468.
    Citations:    
  5. Giovannoni F, Quintana FJ. SARS-CoV-2-induced lung pathology: AHR as a candidate therapeutic target. Cell Res. 2021 01; 31(1):1-2. PMID: 33262451.
    Citations:    
  6. Tsaktanis T, Beyer T, Nirschl L, Linnerbauer M, Grummel V, Bussas M, Tjon E, Mühlau M, Korn T, Hemmer B, Quintana FJ, Rothhammer V. Aryl Hydrocarbon Receptor Plasma Agonist Activity Correlates With Disease Activity in Progressive MS. Neurol Neuroimmunol Neuroinflamm. 2021 Mar; 8(2). PMID: 33361385.
    Citations:    
  7. Kenison JE, Jhaveri A, Li Z, Khadse N, Tjon E, Tezza S, Nowakowska D, Plasencia A, Stanton VP, Sherr DH, Quintana FJ. Tolerogenic nanoparticles suppress central nervous system inflammation. Proc Natl Acad Sci U S A. 2020 Dec 15; 117(50):32017-32028. PMID: 33239445.
    Citations:    
  8. Sungnak W, Wagner A, Kowalczyk MS, Bod L, Kye YC, Sage PT, Sharpe AH, Sobel RA, Quintana FJ, Rozenblatt-Rosen O, Regev A, Wang C, Yosef N, Kuchroo VK. T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity. J Immunol. 2020 Dec 15; 205(12):3247-3262. PMID: 33168576.
    Citations:    
  9. Clark IC, Delley CL, Sun C, Thakur R, Stott SL, Thaploo S, Li Z, Quintana FJ, Abate AR. Targeted Single-Cell RNA and DNA Sequencing With Fluorescence-Activated Droplet Merger. Anal Chem. 2020 11 03; 92(21):14616-14623. PMID: 33049138.
    Citations:    Fields:    
  10. Giovannoni F, Bosch I, Polonio CM, Torti MF, Wheeler MA, Li Z, Romorini L, Rodriguez Varela MS, Rothhammer V, Barroso A, Tjon EC, Sanmarco LM, Takenaka MC, Modaresi SMS, Gutiérrez-Vázquez C, Zanluqui NG, Dos Santos NB, Munhoz CD, Wang Z, Damonte EB, Sherr D, Gehrke L, Peron JPS, Garcia CC, Quintana FJ. Author Correction: AHR is a Zika virus host factor and a candidate target for antiviral therapy. Nat Neurosci. 2020 Oct; 23(10):1307. PMID: 32778795.
    Citations:    Fields:    
  11. Probert L, Quintana FJ, Bar-Or A. Editorial: Update on Translational Neuroimmunology - Research of ISNI 2018. Front Immunol. 2020; 11:2012. PMID: 33101268.
    Citations:    
  12. Badimon A, Strasburger HJ, Ayata P, Chen X, Nair A, Ikegami A, Hwang P, Chan AT, Graves SM, Uweru JO, Ledderose C, Kutlu MG, Wheeler MA, Kahan A, Ishikawa M, Wang YC, Loh YE, Jiang JX, Surmeier DJ, Robson SC, Junger WG, Sebra R, Calipari ES, Kenny PJ, Eyo UB, Colonna M, Quintana FJ, Wake H, Gradinaru V, Schaefer A. Negative feedback control of neuronal activity by microglia. Nature. 2020 10; 586(7829):417-423. PMID: 32999463.
    Citations:    Fields:    
  13. Mendelsohn AC, Sanmarco LM, Spallanzani RG, Brown D, Quintana FJ, Breton S, Battistone MA. From initial segment to cauda: a regional characterization of mouse epididymal CD11c+ mononuclear phagocytes based on immune phenotype and function. Am J Physiol Cell Physiol. 2020 12 01; 319(6):C997-C1010. PMID: 32991210.
    Citations:    
  14. Linnerbauer M, Wheeler MA, Quintana FJ. Astrocyte Crosstalk in CNS Inflammation. Neuron. 2020 11 25; 108(4):608-622. PMID: 32898475.
    Citations:    Fields:    
  15. Giovannoni F, Quintana FJ. The Role of Astrocytes in CNS Inflammation. Trends Immunol. 2020 09; 41(9):805-819. PMID: 32800705.
    Citations:    Fields:    
  16. Giovannoni F, Bosch I, Polonio CM, Torti MF, Wheeler MA, Li Z, Romorini L, Rodriguez Varela MS, Rothhammer V, Barroso A, Tjon EC, Sanmarco LM, Takenaka MC, Modaresi SMS, Gutiérrez-Vázquez C, Zanluqui NG, Dos Santos NB, Munhoz CD, Wang Z, Damonte EB, Sherr D, Gehrke L, Peron JPS, Garcia CC, Quintana FJ. AHR is a Zika virus host factor and a candidate target for antiviral therapy. Nat Neurosci. 2020 08; 23(8):939-951. PMID: 32690969.
    Citations: 2     Fields:    
  17. Xiao S, Bod L, Pochet N, Kota SB, Hu D, Madi A, Kilpatrick J, Shi J, Ho A, Zhang H, Sobel R, Weiner HL, Strom TB, Quintana FJ, Joller N, Kuchroo VK. Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation. Cell Rep. 2020 07 14; 32(2):107892. PMID: 32668241.
    Citations:    Fields:    
  18. Kadowaki A, Quintana FJ. The Gut-CNS Axis in Multiple Sclerosis. Trends Neurosci. 2020 08; 43(8):622-634. PMID: 32650957.
    Citations:    Fields:    
  19. Liu A, Shi FD, Cohen IR, Castaldo G, Matarese G, Quintana FJ, La Cava A. DNA vaccine encoding heat shock protein 90 protects from murine lupus. Arthritis Res Ther. 2020 06 22; 22(1):152. PMID: 32571400.
    Citations:    Fields:    
  20. Sádaba MC, Rothhammer V, Muñoz Ú, Sebal C, Escudero E, Kivisäkk P, Garcia Sanchez MI, Izquierdo G, Hauser SL, Baranzini SE, Oksenberg JR, Álvarez-Lafuente R, Bakshi R, Weiner HL, Quintana FJ. Serum antibodies to phosphatidylcholine in MS. Neurol Neuroimmunol Neuroinflamm. 2020 07; 7(4). PMID: 32518205.
    Citations:    Fields:    
  21. Morianos I, Trochoutsou AI, Papadopoulou G, Semitekolou M, Banos A, Konstantopoulos D, Manousopoulou A, Kapasa M, Wei P, Lomenick B, Belaidi E, Kalamatas T, Karageorgiou K, Doskas T, Sallusto F, Pan F, Garbis SD, Quintana FJ, Xanthou G. Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-a-dependent pathways. Proc Natl Acad Sci U S A. 2020 06 02; 117(22):12269-12280. PMID: 32409602.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  22. Alaamery M, Albesher N, Aljawini N, Alsuwailm M, Massadeh S, Wheeler MA, Chao CC, Quintana FJ. Role of sphingolipid metabolism in neurodegeneration. J Neurochem. 2020 May 13. PMID: 32402091.
    Citations:    Fields:    
  23. Kadowaki A, Quintana FJ. The NLRP3 inflammasome in progressive multiple sclerosis. Brain. 2020 05 01; 143(5):1286-1288. PMID: 32438410.
    Citations:    Fields:    
  24. Gevaert O, Nabian M, Bakr S, Everaert C, Shinde J, Manukyan A, Liefeld T, Tabor T, Xu J, Lupberger J, Haas BJ, Baumert TF, Hernaez M, Reich M, Quintana FJ, Uhlmann EJ, Krichevsky AM, Mesirov JP, Carey V, Pochet N. Imaging-AMARETTO: An Imaging Genomics Software Tool to Interrogate Multiomics Networks for Relevance to Radiography and Histopathology Imaging Biomarkers of Clinical Outcomes. JCO Clin Cancer Inform. 2020 May; 4:421-435. PMID: 32383980.
    Citations: 2     Fields:    
  25. Liu A, Ferretti C, Shi FD, Cohen IR, Quintana FJ, La Cava A. DNA Vaccination With Hsp70 Protects Against Systemic Lupus Erythematosus in (NZB × NZW)F1 Mice. Arthritis Rheumatol. 2020 06; 72(6):997-1002. PMID: 31943822.
    Citations: 2     Fields:    Translation:Animals
  26. Giovannoni F, Li Z, Garcia CC, Quintana FJ. A potential role for AHR in SARS-CoV-2 pathology. Res Sq. 2020 Apr 27. PMID: 32702728.
    Citations:    
  27. Wheeler MA, Clark IC, Tjon EC, Li Z, Zandee SEJ, Couturier CP, Watson BR, Scalisi G, Alkwai S, Rothhammer V, Rotem A, Heyman JA, Thaploo S, Sanmarco LM, Ragoussis J, Weitz DA, Petrecca K, Moffitt JR, Becher B, Antel JP, Prat A, Quintana FJ. MAFG-driven astrocytes promote CNS inflammation. Nature. 2020 02; 578(7796):593-599. PMID: 32051591.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  28. Antel JP, Becher B, Ludwin SK, Prat A, Quintana FJ. Glial Cells as Regulators of Neuroimmune Interactions in the Central Nervous System. J Immunol. 2020 01 15; 204(2):251-255. PMID: 31907266.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  29. Chao CC, Gutiérrez-Vázquez C, Rothhammer V, Mayo L, Wheeler MA, Tjon EC, Zandee SEJ, Blain M, de Lima KA, Takenaka MC, Avila-Pacheco J, Hewson P, Liu L, Sanmarco LM, Borucki DM, Lipof GZ, Trauger SA, Clish CB, Antel JP, Prat A, Quintana FJ. Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS. Cell. 2019 12 12; 179(7):1483-1498.e22. PMID: 31813625.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  30. Araujo LP, Maricato JT, Guereschi MG, Takenaka MC, Nascimento VM, de Melo FM, Quintana FJ, Brum PC, Basso AS. The Sympathetic Nervous System Mitigates CNS Autoimmunity via ß2-Adrenergic Receptor Signaling in Immune Cells. Cell Rep. 2019 Sep 17; 28(12):3120-3130.e5. PMID: 31533035.
    Citations: 1     Fields:    Translation:AnimalsCells
  31. Takenaka MC, Gabriely G, Rothhammer V, Mascanfroni ID, Wheeler MA, Chao CC, Gutiérrez-Vázquez C, Kenison J, Tjon EC, Barroso A, Vandeventer T, de Lima KA, Rothweiler S, Mayo L, Ghannam S, Zandee S, Healy L, Sherr D, Farez MF, Prat A, Antel J, Reardon DA, Zhang H, Robson SC, Getz G, Weiner HL, Quintana FJ. Author Correction: Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci. 2019 Sep; 22(9):1533. PMID: 31197266.
    Citations:    Fields:    
  32. Sanmarco LM, Quintana FJ. Meningeal Memories of Viral Infection. Trends Neurosci. 2019 08; 42(8):513-514. PMID: 31253444.
    Citations:    Fields:    Translation:HumansCells
  33. Gabriely G, Quintana FJ. Role of AHR in the control of GBM-associated myeloid cells. Semin Cancer Biol. 2020 08; 64:13-18. PMID: 31128300.
    Citations: 1     Fields:    
  34. Takenaka MC, Gabriely G, Rothhammer V, Mascanfroni ID, Wheeler MA, Chao CC, Gutiérrez-Vázquez C, Kenison J, Tjon EC, Barroso A, Vandeventer T, de Lima KA, Rothweiler S, Mayo L, Ghannam S, Zandee S, Healy L, Sherr D, Farez MF, Prat A, Antel J, Reardon DA, Zhang H, Robson SC, Getz G, Weiner HL, Quintana FJ. Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci. 2019 05; 22(5):729-740. PMID: 30962630.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  35. Ambrosio LF, Insfran C, Volpini X, Acosta Rodriguez E, Serra HM, Quintana FJ, Cervi L, Motrán CC. Role of Aryl Hydrocarbon Receptor (AhR) in the Regulation of Immunity and Immunopathology During Trypanosoma cruzi Infection. Front Immunol. 2019; 10:631. PMID: 30984194.
    Citations: 1     Fields:    Translation:AnimalsCells
  36. Rothhammer V, Quintana FJ. The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease. Nat Rev Immunol. 2019 03; 19(3):184-197. PMID: 30718831.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  37. Hemond CC, Healy BC, Tauhid S, Mazzola MA, Quintana FJ, Gandhi R, Weiner HL, Bakshi R. MRI phenotypes in MS: Longitudinal changes and miRNA signatures. Neurol Neuroimmunol Neuroinflamm. 2019 03; 6(2):e530. PMID: 30800720.
    Citations: 4     Fields:    Translation:Humans
  38. Quintana FJ. Myeloid cells in the central nervous system: So similar, yet so different. Sci Immunol. 2019 02 08; 4(32). PMID: 30737356.
    Citations:    Fields:    Translation:AnimalsCells
  39. Wheeler MA, Jaronen M, Covacu R, Zandee SEJ, Scalisi G, Rothhammer V, Tjon EC, Chao CC, Kenison JE, Blain M, Rao VTS, Hewson P, Barroso A, Gutiérrez-Vázquez C, Prat A, Antel JP, Hauser R, Quintana FJ. Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation. Cell. 2019 01 24; 176(3):581-596.e18. PMID: 30661753.
    Citations: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  40. Starossom SC, Campo Garcia J, Woelfle T, Romero-Suarez S, Olah M, Watanabe F, Cao L, Yeste A, Tukker JJ, Quintana FJ, Imitola J, Witzel F, Schmitz D, Morkel M, Paul F, Infante-Duarte C, Khoury SJ. Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation. Nat Commun. 2019 01 15; 10(1):217. PMID: 30644388.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  41. Wheeler MA, Quintana FJ. Regulation of Astrocyte Functions in Multiple Sclerosis. Cold Spring Harb Perspect Med. 2019 01 02; 9(1). PMID: 29358321.
    Citations: 4     Fields:    Translation:HumansCells
  42. Quintana FJ. Astrocytes play a crucial role in the formation and evolution of MS lesions - Commentary. Mult Scler. 2019 01; 25(1):19-20. PMID: 30136890.
    Citations: 1     Fields:    Translation:HumansCells
  43. Xie A, Robles RJ, Mukherjee S, Zhang H, Feldbrügge L, Csizmadia E, Wu Y, Enjyoji K, Moss AC, Otterbein LE, Quintana FJ, Robson SC, Longhi MS. HIF-1a-induced xenobiotic transporters promote Th17 responses in Crohn's disease. J Autoimmun. 2018 11; 94:122-133. PMID: 30098863.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  44. Dossi DE, Chaves H, Heck ES, Rodriguez Murúa S, Ventrice F, Bakshi R, Quintana FJ, Correale J, Farez MF. Effects of Systolic Blood Pressure on Brain Integrity in Multiple Sclerosis. Front Neurol. 2018; 9:487. PMID: 29988562.
    Citations:    
  45. Rothhammer V, Borucki DM, Tjon EC, Takenaka MC, Chao CC, Ardura-Fabregat A, de Lima KA, Gutiérrez-Vázquez C, Hewson P, Staszewski O, Blain M, Healy L, Neziraj T, Borio M, Wheeler M, Dragin LL, Laplaud DA, Antel J, Alvarez JI, Prinz M, Quintana FJ. Microglial control of astrocytes in response to microbial metabolites. Nature. 2018 05; 557(7707):724-728. PMID: 29769726.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  46. Rothhammer V, Borucki DM, Kenison JE, Hewson P, Wang Z, Bakshi R, Sherr DH, Quintana FJ. Detection of aryl hydrocarbon receptor agonists in human samples. Sci Rep. 2018 03 21; 8(1):4970. PMID: 29563571.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  47. Dolciami D, Gargaro M, Cerra B, Scalisi G, Bagnoli L, Servillo G, Fazia MAD, Puccetti P, Quintana FJ, Fallarino F, Macchiarulo A. Binding Mode and Structure-Activity Relationships of ITE as an Aryl Hydrocarbon Receptor (AhR) Agonist. ChemMedChem. 2018 02 06; 13(3):270-279. PMID: 29266750.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  48. Gutiérrez-Vázquez C, Quintana FJ. Regulation of the Immune Response by the Aryl Hydrocarbon Receptor. Immunity. 2018 01 16; 48(1):19-33. PMID: 29343438.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  49. Zorrilla-Zubilete MA, Yeste A, Quintana FJ, Toiber D, Mostoslavsky R, Silberman DM. Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6. J Neurochem. 2018 01; 144(2):128-138. PMID: 29049850.
    Citations: 3     Fields:    Translation:AnimalsCells
  50. Quintana FJ, Prinz M. A gut feeling about multiple sclerosis. Proc Natl Acad Sci U S A. 2017 10 03; 114(40):10528-10529. PMID: 28973867.
    Citations:    Fields:    Translation:Humans
  51. Quintana FJ. Astrocytes to the rescue! Glia limitans astrocytic endfeet control CNS inflammation. J Clin Invest. 2017 Aug 01; 127(8):2897-2899. PMID: 28737511.
    Citations: 3     Fields:    Translation:AnimalsCells
  52. Nirschl CJ, Suárez-Fariñas M, Izar B, Prakadan S, Dannenfelser R, Tirosh I, Liu Y, Zhu Q, Devi KSP, Carroll SL, Chau D, Rezaee M, Kim TG, Huang R, Fuentes-Duculan J, Song-Zhao GX, Gulati N, Lowes MA, King SL, Quintana FJ, Lee YS, Krueger JG, Sarin KY, Yoon CH, Garraway L, Regev A, Shalek AK, Troyanskaya O, Anandasabapathy N. IFN?-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment. Cell. 2017 Jun 29; 170(1):127-141.e15. PMID: 28666115.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  53. Rothhammer V, Borucki DM, Garcia Sanchez MI, Mazzola MA, Hemond CC, Regev K, Paul A, Kivisäkk P, Bakshi R, Izquierdo G, Weiner HL, Quintana FJ. Dynamic regulation of serum aryl hydrocarbon receptor agonists in MS. Neurol Neuroimmunol Neuroinflamm. 2017 Jul; 4(4):e359. PMID: 28642887.
    Citations: 7     Fields:    
  54. Wheeler MA, Rothhammer V, Quintana FJ. Control of immune-mediated pathology via the aryl hydrocarbon receptor. J Biol Chem. 2017 07 28; 292(30):12383-12389. PMID: 28615443.
    Citations: 18     Fields:    Translation:HumansAnimals
  55. Longhi MS, Vuerich M, Kalbasi A, Kenison JE, Yeste A, Csizmadia E, Vaughn B, Feldbrugge L, Mitsuhashi S, Wegiel B, Otterbein L, Moss A, Quintana FJ, Robson SC. Bilirubin suppresses Th17 immunity in colitis by upregulating CD39. JCI Insight. 2017 May 04; 2(9). PMID: 28469075.
    Citations: 13     Fields:    
  56. Gabriely G, Wheeler MA, Takenaka MC, Quintana FJ. Role of AHR and HIF-1a in Glioblastoma Metabolism. Trends Endocrinol Metab. 2017 06; 28(6):428-436. PMID: 28318896.
    Citations: 14     Fields:    Translation:Humans
  57. Rothhammer V, Kenison JE, Tjon E, Takenaka MC, de Lima KA, Borucki DM, Chao CC, Wilz A, Blain M, Healy L, Antel J, Quintana FJ. Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):2012-2017. PMID: 28167760.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  58. Kim G, Chu R, Yousuf F, Tauhid S, Stazzone L, Houtchens MK, Stankiewicz JM, Severson C, Kimbrough D, Quintana FJ, Chitnis T, Weiner HL, Healy BC, Bakshi R. Sample size requirements for one-year treatment effects using deep gray matter volume from 3T MRI in progressive forms of multiple sclerosis. Int J Neurosci. 2017 Nov; 127(11):971-980. PMID: 28100092.
    Citations: 4     Fields:    Translation:Humans
  59. Quintana FJ. Dendritic cells in autoimmunity, infections, and cancer. Semin Immunopathol. 2017 02; 39(2):97-98. PMID: 28093619.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  60. Quintana FJ. Old dog, new tricks: IL-6 cluster signaling promotes pathogenic TH17 cell differentiation. Nat Immunol. 2016 12 16; 18(1):8-10. PMID: 27984572.
    Citations: 9     Fields:    Translation:AnimalsCells
  61. Goettel JA, Gandhi R, Kenison JE, Yeste A, Murugaiyan G, Sambanthamoorthy S, Griffith AE, Patel B, Shouval DS, Weiner HL, Snapper SB, Quintana FJ. AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice. Cell Rep. 2016 10 25; 17(5):1318-1329. PMID: 27783946.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  62. Kuhn C, Rezende RM, da Cunha AP, Valette F, Quintana FJ, Chatenoud L, Weiner HL. Mucosal administration of CD3-specific monoclonal antibody inhibits diabetes in NOD mice and in a preclinical mouse model transgenic for the CD3 epsilon chain. J Autoimmun. 2017 01; 76:115-122. PMID: 27745778.
    Citations: 4     Fields:    Translation:AnimalsCells
  63. Rothhammer V, Quintana FJ. Environmental control of autoimmune inflammation in the central nervous system. Curr Opin Immunol. 2016 12; 43:46-53. PMID: 27710839.
    Citations: 16     Fields:    Translation:HumansAnimalsPHPublic Health
  64. Shouval DS, Biswas A, Kang YH, Griffith AE, Konnikova L, Mascanfroni ID, Redhu NS, Frei SM, Field M, Doty AL, Goldsmith JD, Bhan AK, Loizides A, Weiss B, Yerushalmi B, Yanagi T, Lui X, Quintana FJ, Muise AM, Klein C, Horwitz BH, Glover SC, Bousvaros A, Snapper SB. Interleukin 1ß Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency. Gastroenterology. 2016 12; 151(6):1100-1104. PMID: 27693323.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  65. Takenaka MC, Quintana FJ. Tolerogenic dendritic cells. Semin Immunopathol. 2017 02; 39(2):113-120. PMID: 27646959.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  66. Poutiainen P, Jaronen M, Quintana FJ, Brownell AL. Precision Medicine in Multiple Sclerosis: Future of PET Imaging of Inflammation and Reactive Astrocytes. Front Mol Neurosci. 2016; 9:85. PMID: 27695400.
    Citations: 6     
  67. Farez MF, Calandri IL, Correale J, Quintana FJ. Anti-inflammatory effects of melatonin in multiple sclerosis. Bioessays. 2016 10; 38(10):1016-26. PMID: 27561251.
    Citations: 3     Fields:    Translation:HumansAnimals
  68. Jangi S, Gandhi R, Cox LM, Li N, von Glehn F, Yan R, Patel B, Mazzola MA, Liu S, Glanz BL, Cook S, Tankou S, Stuart F, Melo K, Nejad P, Smith K, Topçuolu BD, Holden J, Kivisäkk P, Chitnis T, De Jager PL, Quintana FJ, Gerber GK, Bry L, Weiner HL. Alterations of the human gut microbiome in multiple sclerosis. Nat Commun. 2016 06 28; 7:12015. PMID: 27352007.
    Citations: 175     Fields:    Translation:HumansCells
  69. Quintana FJ, VanHook AM. Science Signaling Podcast for 21 June 2016: Nanoparticles to treat type 1 diabetes. Sci Signal. 2016 06 21; 9(433):c15. PMID: 27330187.
    Citations:    Fields:    Translation:HumansAnimalsCells
  70. Yeste A, Takenaka MC, Mascanfroni ID, Nadeau M, Kenison JE, Patel B, Tukpah AM, Babon JA, DeNicola M, Kent SC, Pozo D, Quintana FJ. Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2. Sci Signal. 2016 06 21; 9(433):ra61. PMID: 27330188.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  71. Fernández D, Flores-Santibáñez F, Neira J, Osorio-Barrios F, Tejón G, Nuñez S, Hidalgo Y, Fuenzalida MJ, Meza D, Ureta G, Lladser A, Pacheco R, Acuña-Castillo C, Guixé V, Quintana FJ, Bono MR, Rosemblatt M, Sauma D. Purinergic Signaling as a Regulator of Th17 Cell Plasticity. PLoS One. 2016; 11(6):e0157889. PMID: 27322617.
    Citations: 9     Fields:    Translation:AnimalsCells
  72. Sisirak V, Sally B, D'Agati V, Martinez-Ortiz W, Özçakar ZB, David J, Rashidfarrokhi A, Yeste A, Panea C, Chida AS, Bogunovic M, Ivanov II, Quintana FJ, Sanz I, Elkon KB, Tekin M, Yalçinkaya F, Cardozo TJ, Clancy RM, Buyon JP, Reizis B. Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity. Cell. 2016 Jun 30; 166(1):88-101. PMID: 27293190.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  73. Mayo L, Cunha AP, Madi A, Beynon V, Yang Z, Alvarez JI, Prat A, Sobel RA, Kobzik L, Lassmann H, Quintana FJ, Weiner HL. IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation. Brain. 2016 07; 139(Pt 7):1939-57. PMID: 27246324.
    Citations: 18     Fields:    Translation:AnimalsCells
  74. Takenaka MC, Robson S, Quintana FJ. Regulation of the T Cell Response by CD39. Trends Immunol. 2016 07; 37(7):427-439. PMID: 27236363.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  75. Rothhammer V, Mascanfroni ID, Bunse L, Takenaka MC, Kenison JE, Mayo L, Chao CC, Patel B, Yan R, Blain M, Alvarez JI, Kébir H, Anandasabapathy N, Izquierdo G, Jung S, Obholzer N, Pochet N, Clish CB, Prinz M, Prat A, Antel J, Quintana FJ. Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Nat Med. 2016 06; 22(6):586-97. PMID: 27158906.
    Citations: 154     Fields:    Translation:HumansAnimalsCells
  76. Covacu R, Philip H, Jaronen M, Almeida J, Kenison JE, Darko S, Chao CC, Yaari G, Louzoun Y, Carmel L, Douek DC, Efroni S, Quintana FJ. System-wide Analysis of the T Cell Response. Cell Rep. 2016 Mar 22; 14(11):2733-44. PMID: 26972015.
    Citations: 11     Fields:    Translation:AnimalsCells
  77. Bakshi R, Yeste A, Patel B, Tauhid S, Tummala S, Rahbari R, Chu R, Regev K, Kivisäkk P, Weiner HL, Quintana FJ. Serum lipid antibodies are associated with cerebral tissue damage in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2016 Apr; 3(2):e200. PMID: 26894204.
    Citations: 13     Fields:    
  78. Caballero-Hernandez D, Toscano MG, Cejudo-Guillen M, Garcia-Martin ML, Lopez S, Franco JM, Quintana FJ, Roodveldt C, Pozo D. The 'Omics' of Amyotrophic Lateral Sclerosis. Trends Mol Med. 2016 Jan; 22(1):53-67. PMID: 26691296.
    Citations: 4     Fields:    Translation:Humans
  79. Takenaka MC, Quintana FJ. Achieving Tolerance with Perforin-Secreting Dendritic Cells. Trends Mol Med. 2016 Jan; 22(1):3-4. PMID: 26700492.
    Citations: 1     Fields:    Translation:AnimalsCells
  80. Takenaka MC, Araujo LP, Maricato JT, Nascimento VM, Guereschi MG, Rezende RM, Quintana FJ, Basso AS. Norepinephrine Controls Effector T Cell Differentiation through ß2-Adrenergic Receptor-Mediated Inhibition of NF-?B and AP-1 in Dendritic Cells. J Immunol. 2016 Jan 15; 196(2):637-44. PMID: 26663782.
    Citations: 15     Fields:    Translation:AnimalsCells
  81. Farez MF, Mascanfroni ID, Méndez-Huergo SP, Yeste A, Murugaiyan G, Garo LP, Balbuena Aguirre ME, Patel B, Ysrraelit MC, Zhu C, Kuchroo VK, Rabinovich GA, Quintana FJ, Correale J. Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses. Cell. 2015 Sep 10; 162(6):1338-52. PMID: 26359987.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  82. Rothhammer V, Quintana FJ. Role of astrocytes and microglia in central nervous system inflammation. Introduction. Semin Immunopathol. 2015 Nov; 37(6):575-6. PMID: 26271223.
    Citations: 4     Fields:    Translation:HumansCells
  83. Rothhammer V, Quintana FJ. Control of autoimmune CNS inflammation by astrocytes. Semin Immunopathol. 2015 Nov; 37(6):625-38. PMID: 26223505.
    Citations: 35     Fields:    Translation:HumansCells
  84. Mascanfroni ID, Takenaka MC, Yeste A, Patel B, Wu Y, Kenison JE, Siddiqui S, Basso AS, Otterbein LE, Pardoll DM, Pan F, Priel A, Clish CB, Robson SC, Quintana FJ. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-a. Nat Med. 2015 Jun; 21(6):638-46. PMID: 26005855.
    Citations: 114     Fields:    Translation:HumansAnimalsCells
  85. Goettel JA, Biswas S, Lexmond WS, Yeste A, Passerini L, Patel B, Yang S, Sun J, Ouahed J, Shouval DS, McCann KJ, Horwitz BH, Mathis D, Milford EL, Notarangelo LD, Roncarolo MG, Fiebiger E, Marasco WA, Bacchetta R, Quintana FJ, Pai SY, Klein C, Muise AM, Snapper SB. Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3. Blood. 2015 Jun 18; 125(25):3886-95. PMID: 25833964.
    Citations: 12     Fields:    Translation:HumansAnimals
  86. Quintana FJ, Patel B, Yeste A, Nyirenda M, Kenison J, Rahbari R, Fetco D, Hussain M, O'Mahony J, Magalhaes S, McGowan M, Johnson T, Rajasekharan S, Narayanan S, Arnold DL, Weiner HL, Banwell B, Bar-Or A. Epitope spreading as an early pathogenic event in pediatric multiple sclerosis. Neurology. 2014 Dec 09; 83(24):2219-26. PMID: 25381299.
    Citations: 10     Fields:    Translation:Humans
  87. Yeste A, Quintana FJ. [The microprobes of antigens for studying of autoimmune diseases]. Klin Lab Diagn. 2014 Nov; 59(11):10-7. PMID: 25850238.
    Citations:    Fields:    Translation:HumansCells
  88. Jaronen M, Quintana FJ. Immunological Relevance of the Coevolution of IDO1 and AHR. Front Immunol. 2014; 5:521. PMID: 25368620.
    Citations: 25     Fields:    
  89. Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivisäkk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, Quintana FJ. Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Nat Med. 2014 Oct; 20(10):1147-56. PMID: 25216636.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  90. Quintana FJ, Yeste A, Mascanfroni ID. Role and therapeutic value of dendritic cells in central nervous system autoimmunity. Cell Death Differ. 2015 Feb; 22(2):215-24. PMID: 25168240.
    Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
  91. Farez MF, Fiol MP, Gaitán MI, Quintana FJ, Correale J. Sodium intake is associated with increased disease activity in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2015 Jan; 86(1):26-31. PMID: 25168393.
    Citations: 58     Fields:    Translation:Humans
  92. Quintana FJ. LeA(H)Rning self-control. Cell Res. 2014 Oct; 24(10):1155-6. PMID: 25060701.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  93. Quinn DM, Williams MK, Quintana F, Gaskins JL, Overstreet NM, Pishori A, Earnshaw VA, Perez G, Chaudoir SR. Examining effects of anticipated stigma, centrality, salience, internalization, and outness on psychological distress for people with concealable stigmatized identities. PLoS One. 2014; 9(5):e96977. PMID: 24817189.
    Citations: 16     Fields:    Translation:Humans
  94. Yeste A, Mascanfroni ID, Nadeau M, Burns EJ, Tukpah AM, Santiago A, Wu C, Patel B, Kumar D, Quintana FJ. IL-21 induces IL-22 production in CD4+ T cells. Nat Commun. 2014 May 06; 5:3753. PMID: 24796415.
    Citations: 40     Fields:    Translation:HumansCells
  95. Shouval DS, Biswas A, Goettel JA, McCann K, Conaway E, Redhu NS, Mascanfroni ID, Al Adham Z, Lavoie S, Ibourk M, Nguyen DD, Samsom JN, Escher JC, Somech R, Weiss B, Beier R, Conklin LS, Ebens CL, Santos FG, Ferreira AR, Sherlock M, Bhan AK, Müller W, Mora JR, Quintana FJ, Klein C, Muise AM, Horwitz BH, Snapper SB. Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity. 2014 May 15; 40(5):706-19. PMID: 24792912.
    Citations: 134     Fields:    Translation:HumansAnimalsCells
  96. Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, Kuchroo VK. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity. 2014 Apr 17; 40(4):569-81. PMID: 24745333.
    Citations: 160     Fields:    Translation:AnimalsCells
  97. Longhi MS, Moss A, Bai A, Wu Y, Huang H, Cheifetz A, Quintana FJ, Robson SC. Characterization of human CD39+ Th17 cells with suppressor activity and modulation in inflammatory bowel disease. PLoS One. 2014; 9(2):e87956. PMID: 24505337.
    Citations: 26     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  98. Moraes-Vieira PM, Larocca RA, Bassi EJ, Peron JP, Andrade-Oliveira V, Wasinski F, Araujo R, Thornley T, Quintana FJ, Basso AS, Strom TB, Câmara NO. Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells. Eur J Immunol. 2014 Mar; 44(3):794-806. PMID: 24271843.
    Citations: 19     Fields:    Translation:AnimalsCells
  99. Quintana FJ, Pérez-Sánchez S, Farez MF. [Immunopathology of multiple sclerosis]. Medicina (B Aires). 2014; 74(5):404-10. PMID: 25347906.
    Citations:    Fields:    Translation:HumansCells
  100. Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK. Corrigendum: Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat Immunol. 2013 Dec 18; 15(1):109. PMID: 24352327.
    Citations:    
  101. Pot C, Quintana FJ, Kuchroo VK. Fine tuning of the immune response by the Aryl Hydrocarbon Receptor. Semin Immunopathol. 2013 Nov; 35(6):613. PMID: 24104867.
    Citations:    
  102. Kivisäkk P, Healy BC, Francois K, Gandhi R, Gholipour T, Egorova S, Sevdalinova V, Quintana F, Chitnis T, Weiner HL, Khoury SJ. Evaluation of circulating osteopontin levels in an unselected cohort of patients with multiple sclerosis: relevance for biomarker development. Mult Scler. 2014 Apr; 20(4):438-44. PMID: 24005026.
    Citations: 9     Fields:    Translation:Humans
  103. Quintana FJ. Regulation of central nervous system autoimmunity by the aryl hydrocarbon receptor. Semin Immunopathol. 2013 Nov; 35(6):627-35. PMID: 23999753.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  104. Mascanfroni ID, Yeste A, Vieira SM, Burns EJ, Patel B, Sloma I, Wu Y, Mayo L, Ben-Hamo R, Efroni S, Kuchroo VK, Robson SC, Quintana FJ. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat Immunol. 2013 Oct; 14(10):1054-63. PMID: 23995234.
    Citations: 105     Fields:    Translation:AnimalsCells
  105. Quintana FJ, Sherr DH. Aryl hydrocarbon receptor control of adaptive immunity. Pharmacol Rev. 2013; 65(4):1148-61. PMID: 23908379.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  106. Gandhi R, Healy B, Gholipour T, Egorova S, Musallam A, Hussain MS, Nejad P, Patel B, Hei H, Khoury S, Quintana F, Kivisakk P, Chitnis T, Weiner HL. Circulating microRNAs as biomarkers for disease staging in multiple sclerosis. Ann Neurol. 2013 Jun; 73(6):729-40. PMID: 23494648.
    Citations: 70     Fields:    Translation:Humans
  107. Quintana FJ. Nanoparticles for the induction of antigen-specific Tregs. Immunotherapy. 2013 May; 5(5):437-40. PMID: 23638737.
    Citations: 2     Fields:    Translation:HumansCells
  108. Ahmed ST, Akirav E, Bradshaw E, Buckner J, McKinney E, Quintana FJ, Waldron-Lynch F, Nepom J. Immunological biomarkers: catalysts for translational advances in autoimmune diabetes. Clin Exp Immunol. 2013 May; 172(2):178-85. PMID: 23574315.
    Citations: 3     Fields:    Translation:HumansCells
  109. Bransburg-Zabary S, Kenett DY, Dar G, Madi A, Merbl Y, Quintana FJ, Tauber AI, Cohen IR, Ben-Jacob E. Individual and meta-immune networks. Phys Biol. 2013 Apr; 10(2):025003. PMID: 23492831.
    Citations: 4     Fields:    Translation:Humans
  110. Yeste A, Quintana FJ. Antigen microarrays for the study of autoimmune diseases. Clin Chem. 2013 Jul; 59(7):1036-44. PMID: 23487172.
    Citations: 11     Fields:    Translation:Humans
  111. Quintana FJ. The aryl hydrocarbon receptor: a molecular pathway for the environmental control of the immune response. Immunology. 2013 Mar; 138(3):183-9. PMID: 23190340.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  112. Moraes-Vieira PM, Bassi EJ, Larocca RA, Castoldi A, Burghos M, Lepique AP, Quintana FJ, Araujo RC, Basso AS, Strom TB, Câmara NO. Leptin deficiency modulates allograft survival by favoring a Th2 and a regulatory immune profile. [corrected]. Am J Transplant. 2013 Jan; 13(1):36-44. PMID: 23016759.
    Citations: 15     Fields:    Translation:AnimalsCells
  113. Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK. Induction and molecular signature of pathogenic TH17 cells. Nat Immunol. 2012 Oct; 13(10):991-9. PMID: 22961052.
    Citations: 347     Fields:    Translation:HumansAnimalsCells
  114. Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK. Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):12105-10. PMID: 22773818.
    Citations: 45     Fields:    Translation:AnimalsCells
  115. Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK. Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat Immunol. 2012 Jul 01; 13(8):770-7. PMID: 22751139.
    Citations: 97     Fields:    Translation:AnimalsCells
  116. Mayo L, Quintana FJ, Weiner HL. The innate immune system in demyelinating disease. Immunol Rev. 2012 Jul; 248(1):170-87. PMID: 22725961.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  117. Beynon V, Quintana FJ, Weiner HL. Activated human CD4+CD45RO+ memory T-cells indirectly inhibit NLRP3 inflammasome activation through downregulation of P2X7R signalling. PLoS One. 2012; 7(6):e39576. PMID: 22768094.
    Citations: 11     Fields:    Translation:HumansCells
  118. Yeste A, Nadeau M, Burns EJ, Weiner HL, Quintana FJ. Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11270-5. PMID: 22745170.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  119. Quintana FJ, Yeste A, Weiner HL, Covacu R. Lipids and lipid-reactive antibodies as biomarkers for multiple sclerosis. J Neuroimmunol. 2012 Jul 15; 248(1-2):53-7. PMID: 22579051.
    Citations: 20     Fields:    Translation:HumansAnimals
  120. Quintana FJ, Farez MF, Izquierdo G, Lucas M, Cohen IR, Weiner HL. Antigen microarrays identify CNS-produced autoantibodies in RRMS. Neurology. 2012 Feb 21; 78(8):532-9. PMID: 22262743.
    Citations: 27     Fields:    Translation:HumansCells
  121. Liu SM, Sutherland AP, Zhang Z, Rainbow DB, Quintana FJ, Paterson AM, Sharpe AH, Oukka M, Wicker LS, Kuchroo VK. Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity. J Immunol. 2012 Jan 01; 188(1):155-62. PMID: 22124121.
    Citations: 12     Fields:    Translation:AnimalsCells
  122. Cassani B, Villablanca EJ, Quintana FJ, Love PE, Lacy-Hulbert A, Blaner WS, Sparwasser T, Snapper SB, Weiner HL, Mora JR. Gut-tropic T cells that express integrin a4ß7 and CCR9 are required for induction of oral immune tolerance in mice. Gastroenterology. 2011 Dec; 141(6):2109-18. PMID: 21925467.
    Citations: 58     Fields:    Translation:AnimalsCells
  123. Wu HY, Quintana FJ, da Cunha AP, Dake BT, Koeglsperger T, Starossom SC, Weiner HL. In vivo induction of Tr1 cells via mucosal dendritic cells and AHR signaling. PLoS One. 2011; 6(8):e23618. PMID: 21886804.
    Citations: 43     Fields:    Translation:AnimalsCells
  124. Weiner HL, da Cunha AP, Quintana F, Wu H. Oral tolerance. Immunol Rev. 2011 May; 241(1):241-59. PMID: 21488901.
    Citations: 192     Fields:    Translation:HumansAnimalsCells
  125. Madi A, Kenett DY, Bransburg-Zabary S, Merbl Y, Quintana FJ, Tauber AI, Cohen IR, Ben-Jacob E. Network theory analysis of antibody-antigen reactivity data: the immune trees at birth and adulthood. PLoS One. 2011 Mar 08; 6(3):e17445. PMID: 21408156.
    Citations: 7     Fields:    Translation:Humans
  126. Madi A, Kenett DY, Bransburg-Zabary S, Merbl Y, Quintana FJ, Boccaletti S, Tauber AI, Cohen IR, Ben-Jacob E. Analyses of antigen dependency networks unveil immune system reorganization between birth and adulthood. Chaos. 2011 Mar; 21(1):016109. PMID: 21456851.
    Citations: 5     Fields:    Translation:Humans
  127. Quintana FJ, Cohen IR. The HSP60 immune system network. Trends Immunol. 2011 Feb; 32(2):89-95. PMID: 21145789.
    Citations: 44     Fields:    Translation:HumansAnimals
  128. Quintana FJ, Murugaiyan G, Farez MF, Mitsdoerffer M, Tukpah AM, Burns EJ, Weiner HL. An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2010 Nov 30; 107(48):20768-73. PMID: 21068375.
    Citations: 142     Fields:    Translation:AnimalsCells
  129. Gandhi R, Kumar D, Burns EJ, Nadeau M, Dake B, Laroni A, Kozoriz D, Weiner HL, Quintana FJ. Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells. Nat Immunol. 2010 Sep; 11(9):846-53. PMID: 20676092.
    Citations: 135     Fields:    Translation:HumansAnimalsCells
  130. Apetoh L, Quintana FJ, Pot C, Joller N, Xiao S, Kumar D, Burns EJ, Sherr DH, Weiner HL, Kuchroo VK. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat Immunol. 2010 Sep; 11(9):854-61. PMID: 20676095.
    Citations: 254     Fields:    Translation:AnimalsCells
  131. Dardalhon V, Anderson AC, Karman J, Apetoh L, Chandwaskar R, Lee DH, Cornejo M, Nishi N, Yamauchi A, Quintana FJ, Sobel RA, Hirashima M, Kuchroo VK. Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells. J Immunol. 2010 Aug 01; 185(3):1383-92. PMID: 20574007.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  132. Rodriguez-Manzanet R, Sanjuan MA, Wu HY, Quintana FJ, Xiao S, Anderson AC, Weiner HL, Green DR, Kuchroo VK. T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8706-11. PMID: 20368430.
    Citations: 76     Fields:    Translation:AnimalsCells
  133. Gandhi R, Farez MF, Wang Y, Kozoriz D, Quintana FJ, Weiner HL. Cutting edge: human latency-associated peptide+ T cells: a novel regulatory T cell subset. J Immunol. 2010 May 01; 184(9):4620-4. PMID: 20368276.
    Citations: 49     Fields:    Translation:HumansCells
  134. Quintana FJ, Iglesias AH, Farez MF, Caccamo M, Burns EJ, Kassam N, Oukka M, Weiner HL. Adaptive autoimmunity and Foxp3-based immunoregulation in zebrafish. PLoS One. 2010 Mar 05; 5(3):e9478. PMID: 20221429.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  135. Ilan Y, Zigmond E, Lalazar G, Dembinsky A, Ben Ya'acov A, Hemed N, Kasis I, Axelrod E, Zolotarov L, Klein A, El Haj M, Gandhi R, Baecher-Allan C, Wu H, Murugaiyan G, Kivisakk P, Farez MF, Quintana FJ, Khoury SJ, Weiner HL. Oral administration of OKT3 monoclonal antibody to human subjects induces a dose-dependent immunologic effect in T cells and dendritic cells. J Clin Immunol. 2010 Jan; 30(1):167-77. PMID: 19756989.
    Citations: 24     Fields:    Translation:HumansCellsCTClinical Trials
  136. Herrera JL, Gonzalez-Rey E, Fernandez-Montesinos R, Quintana FJ, Najmanovich R, Pozo D. Toll-like receptor stimulation differentially regulates vasoactive intestinal peptide type 2 receptor in macrophages. J Cell Mol Med. 2009 Sep; 13(9B):3209-17. PMID: 20196778.
    Citations: 10     Fields:    Translation:AnimalsCells
  137. Farez MF, Quintana FJ, Gandhi R, Izquierdo G, Lucas M, Weiner HL. Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE. Nat Immunol. 2009 Sep; 10(9):958-64. PMID: 19684606.
    Citations: 71     Fields:    Translation:HumansAnimals
  138. Madi A, Hecht I, Bransburg-Zabary S, Merbl Y, Pick A, Zucker-Toledano M, Quintana FJ, Tauber AI, Cohen IR, Ben-Jacob E. Organization of the autoantibody repertoire in healthy newborns and adults revealed by system level informatics of antigen microarray data. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14484-9. PMID: 19667184.
    Citations: 30     Fields:    Translation:Humans
  139. Merbl Y, Itzchak R, Vider-Shalit T, Louzoun Y, Quintana FJ, Vadai E, Eisenbach L, Cohen IR. A systems immunology approach to the host-tumor interaction: large-scale patterns of natural autoantibodies distinguish healthy and tumor-bearing mice. PLoS One. 2009 Jun 25; 4(6):e6053. PMID: 19557135.
    Citations: 11     Fields:    Translation:AnimalsCells
  140. Kivisäkk P, Healy BC, Viglietta V, Quintana FJ, Hootstein MA, Weiner HL, Khoury SJ. Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells. Neurology. 2009 Jun 02; 72(22):1922-30. PMID: 19487650.
    Citations: 50     Fields:    Translation:HumansCells
  141. Quintana FJ, Weiner HL. Environmental control of Th17 differentiation. Eur J Immunol. 2009 Mar; 39(3):655-7. PMID: 19283716.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  142. Quintana FJ, Mimran A, Carmi P, Mor F, Cohen IR. HSP60 as a target of anti-ergotypic regulatory T cells. PLoS One. 2008; 3(12):e4026. PMID: 19107191.
    Citations: 8     Fields:    Translation:AnimalsCells
  143. Quintana FJ, Farez MF, Viglietta V, Iglesias AH, Merbl Y, Izquierdo G, Lucas M, Basso AS, Khoury SJ, Lucchinetti CF, Cohen IR, Weiner HL. Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis. Proc Natl Acad Sci U S A. 2008 Dec 02; 105(48):18889-94. PMID: 19028871.
    Citations: 88     Fields:    Translation:HumansAnimals
  144. Wu HY, Quintana FJ, Weiner HL. Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells. J Immunol. 2008 Nov 01; 181(9):6038-50. PMID: 18941193.
    Citations: 66     Fields:    Translation:AnimalsCells
  145. Quintana FJ, Solomon A, Cohen IR, Nussbaum G. Induction of IgG3 to LPS via Toll-like receptor 4 co-stimulation. PLoS One. 2008; 3(10):e3509. PMID: 18946502.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  146. Quintana FJ, Farez MF, Weiner HL. Systems biology approaches for the study of multiple sclerosis. J Cell Mol Med. 2008 Aug; 12(4):1087-93. PMID: 18505469.
    Citations: 10     Fields:    Translation:HumansAnimals
  147. Basso AS, Frenkel D, Quintana FJ, Costa-Pinto FA, Petrovic-Stojkovic S, Puckett L, Monsonego A, Bar-Shir A, Engel Y, Gozin M, Weiner HL. Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis. J Clin Invest. 2008 Apr; 118(4):1532-43. PMID: 18340379.
    Citations: 65     Fields:    Translation:AnimalsCells
  148. Quintana FJ, Cohen IR. Regulatory T cells and immune computation. Eur J Immunol. 2008 Apr; 38(4):903-7. PMID: 18395856.
    Citations: 2     Fields:    Translation:Cells
  149. Quintana FJ, Basso AS, Iglesias AH, Korn T, Farez MF, Bettelli E, Caccamo M, Oukka M, Weiner HL. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature. 2008 May 01; 453(7191):65-71. PMID: 18362915.
    Citations: 576     Fields:    Translation:HumansAnimalsCells
  150. Quintana FJ, Cohen IR. HSP60 speaks to the immune system in many voices. Novartis Found Symp. 2008; 291:101-11; discussion 111-4, 137-40. PMID: 18575269.
    Citations: 7     Fields:    Translation:Humans
  151. Baharav E, Mor F, Halpern M, Quintana F, Weinberger A. Tropomyosin-induced arthritis in rats. Clin Exp Rheumatol. 2007 Jul-Aug; 25(4 Suppl 45):S86-92. PMID: 17949558.
    Citations:    Fields:    Translation:Animals
  152. Shternhall-Ron K, Quintana FJ, Perl S, Meivar-Levy I, Barshack I, Cohen IR, Ferber S. Ectopic PDX-1 expression in liver ameliorates type 1 diabetes. J Autoimmun. 2007 Mar-May; 28(2-3):134-42. PMID: 17383157.
    Citations: 21     Fields:    Translation:AnimalsCells
  153. Merbl Y, Zucker-Toledano M, Quintana FJ, Cohen IR. Newborn humans manifest autoantibodies to defined self molecules detected by antigen microarray informatics. J Clin Invest. 2007 Mar; 117(3):712-8. PMID: 17332892.
    Citations: 78     Fields:    Translation:Humans
  154. Quintana FJ, Gerber D, Bloch I, Cohen IR, Shai Y. A structurally altered D,L-amino acid TCRalpha transmembrane peptide interacts with the TCRalpha and inhibits T-cell activation in vitro and in an animal model. Biochemistry. 2007 Mar 06; 46(9):2317-25. PMID: 17288453.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  155. Bloch I, Quintana FJ, Gerber D, Cohen T, Cohen IR, Shai Y. T-cell inactivation and immunosuppressive activity induced by HIV gp41 via novel interacting motif. FASEB J. 2007 Feb; 21(2):393-401. PMID: 17185749.
    Citations: 17     Fields:    Translation:AnimalsCells
  156. Quintana FJ, Cohen IR. Anti-ergotypic immunoregulation. Scand J Immunol. 2006 Sep; 64(3):205-10. PMID: 16918688.
    Citations: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  157. Nussbaum G, Zanin-Zhorov A, Quintana F, Lider O, Cohen IR. Peptide p277 of HSP60 signals T cells: inhibition of inflammatory chemotaxis. Int Immunol. 2006 Oct; 18(10):1413-9. PMID: 16893923.
    Citations: 10     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  158. Quintana FJ, Zaltzman R, Fernandez-Montesinos R, Herrera JL, Gozes I, Cohen IR, Pozo D. NAP, a peptide derived from the activity-dependent neuroprotective protein, modulates macrophage function. Ann N Y Acad Sci. 2006 Jul; 1070:500-6. PMID: 16888216.
    Citations: 20     Fields:    Translation:AnimalsCells
  159. Quintana FJ, Weiner HL. Understanding natural and pathological autoimmunity. J Neuroimmunol. 2006 May; 174(1-2):1-2. PMID: 16533538.
    Citations: 2     Fields:    Translation:HumansAnimals
  160. Quintana FJ, Merbl Y, Sahar E, Domany E, Cohen IR. Antigen-chip technology for accessing global information about the state of the body. Lupus. 2006; 15(7):428-30. PMID: 16898177.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  161. Quintana FJ, Cohen IR. Heat shock proteins as endogenous adjuvants in sterile and septic inflammation. J Immunol. 2005 Sep 01; 175(5):2777-82. PMID: 16116161.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  162. Quintana FJ, Gerber D, Kent SC, Cohen IR, Shai Y. HIV-1 fusion peptide targets the TCR and inhibits antigen-specific T cell activation. J Clin Invest. 2005 Aug; 115(8):2149-58. PMID: 16007266.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  163. Mimran A, Mor F, Quintana FJ, Cohen IR. Anti-ergotypic T cells in naïve rats. J Autoimmun. 2005 May; 24(3):191-201. PMID: 15848041.
    Citations: 3     Fields:    Translation:AnimalsCells
  164. Gerber D, Quintana FJ, Bloch I, Cohen IR, Shai Y. D-enantiomer peptide of the TCRalpha transmembrane domain inhibits T-cell activation in vitro and in vivo. FASEB J. 2005 Jul; 19(9):1190-2. PMID: 15837719.
    Citations: 15     Fields:    Translation:AnimalsCells
  165. Quintana FJ, Cohen IR. DNA vaccines coding for heat-shock proteins (HSPs): tools for the activation of HSP-specific regulatory T cells. Expert Opin Biol Ther. 2005 Apr; 5(4):545-54. PMID: 15934832.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  166. Cohen IR, Quintana FJ, Mimran A. Tregs in T cell vaccination: exploring the regulation of regulation. J Clin Invest. 2004 Nov; 114(9):1227-32. PMID: 15520852.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  167. Quintana FJ, Carmi P, Mor F, Cohen IR. Inhibition of adjuvant-induced arthritis by DNA vaccination with the 70-kd or the 90-kd human heat-shock protein: immune cross-regulation with the 60-kd heat-shock protein. Arthritis Rheum. 2004 Nov; 50(11):3712-20. PMID: 15529360.
    Citations: 17     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  168. Quintana FJ, Hagedorn PH, Elizur G, Merbl Y, Domany E, Cohen IR. Functional immunomics: microarray analysis of IgG autoantibody repertoires predicts the future response of mice to induced diabetes. Proc Natl Acad Sci U S A. 2004 Oct 05; 101 Suppl 2:14615-21. PMID: 15308778.
    Citations: 45     Fields:    Translation:AnimalsCells
  169. Quintana FJ, Cohen IR. The natural autoantibody repertoire and autoimmune disease. Biomed Pharmacother. 2004 Jun; 58(5):276-81. PMID: 15194162.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  170. Quintana FJ, Buzas E, Prohászka Z, Bíró A, Kocsis J, Füst G, Falus A, Cohen IR. Knock-out of the histidine decarboxylase gene modifies the repertoire of natural autoantibodies. J Autoimmun. 2004 Jun; 22(4):297-305. PMID: 15120753.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  171. Mor F, Quintana FJ, Cohen IR. Angiogenesis-inflammation cross-talk: vascular endothelial growth factor is secreted by activated T cells and induces Th1 polarization. J Immunol. 2004 Apr 01; 172(7):4618-23. PMID: 15034080.
    Citations: 78     Fields:    Translation:AnimalsCells
  172. Mimran A, Mor F, Carmi P, Quintana FJ, Rotter V, Cohen IR. DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response. J Clin Invest. 2004 Mar; 113(6):924-32. PMID: 15067325.
    Citations: 8     Fields:    Translation:AnimalsCells
  173. Nahum R, Brenner O, Zahalka MA, Traub L, Quintana F, Moroz C. Blocking of the placental immune-modulatory ferritin activates Th1 type cytokines and affects placenta development, fetal growth and the pregnancy outcome. Hum Reprod. 2004 Mar; 19(3):715-22. PMID: 14998975.
    Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
  174. Quintana FJ, Carmi P, Mor F, Cohen IR. DNA fragments of the human 60-kDa heat shock protein (HSP60) vaccinate against adjuvant arthritis: identification of a regulatory HSP60 peptide. J Immunol. 2003 Oct 01; 171(7):3533-41. PMID: 14500649.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  175. Quintana FJ, Getz G, Hed G, Domany E, Cohen IR. Cluster analysis of human autoantibody reactivities in health and in type 1 diabetes mellitus: a bio-informatic approach to immune complexity. J Autoimmun. 2003 Aug; 21(1):65-75. PMID: 12892737.
    Citations: 15     Fields:    Translation:Humans
  176. Weinberger A, Halpern M, Zahalka MA, Quintana F, Traub L, Moroz C. Placental immunomodulator ferritin, a novel immunoregulator, suppresses experimental arthritis. Arthritis Rheum. 2003 Mar; 48(3):846-53. PMID: 12632441.
    Citations: 7     Fields:    Translation:AnimalsCells
  177. Quintana FJ, Pitashny M, Cohen IR. Experimental autoimmune myasthenia gravis in naive non-obese diabetic (NOD/LtJ) mice: susceptibility associated with natural IgG antibodies to the acetylcholine receptor. Int Immunol. 2003 Jan; 15(1):11-6. PMID: 12502721.
    Citations: 3     Fields:    Translation:Animals
  178. Mor F, Quintana F, Mimran A, Cohen IR. Autoimmune encephalomyelitis and uveitis induced by T cell immunity to self beta-synuclein. J Immunol. 2003 Jan 01; 170(1):628-34. PMID: 12496452.
    Citations: 6     Fields:    Translation:AnimalsCellsPHPublic Health
  179. Quintana FJ, Carmi P, Cohen IR. DNA vaccination with heat shock protein 60 inhibits cyclophosphamide-accelerated diabetes. J Immunol. 2002 Nov 15; 169(10):6030-5. PMID: 12421990.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  180. Quintana FJ, Carmi P, Mor F, Cohen IR. Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60. J Immunol. 2002 Sep 15; 169(6):3422-8. PMID: 12218165.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  181. Quintana FJ, Cohen IR. Autoantibody patterns in diabetes-prone NOD mice and in standard C57BL/6 mice. J Autoimmun. 2001 Nov; 17(3):191-7. PMID: 11712856.
    Citations: 13     Fields:    Translation:Animals
  182. Harz C, Río JA, Quintana F, Vera E. [Common bilio pancreatic channel syndrome in adults]. Rev Med Chil. 2001 Mar; 129(3):299-302. PMID: 11372298.
    Citations:    Fields:    Translation:Humans
  183. Quintana FJ, Rotem A, Carmi P, Cohen IR. Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: modulation of spontaneous 60-kDa heat shock protein autoimmunity. J Immunol. 2000 Dec 01; 165(11):6148-55. PMID: 11086048.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  184. Ablamunits V, Quintana F, Reshef T, Elias D, Cohen IR. Acceleration of autoimmune diabetes by cyclophosphamide is associated with an enhanced IFN-gamma secretion pathway. J Autoimmun. 1999 Dec; 13(4):383-92. PMID: 10585754.
    Citations: 17     Fields:    Translation:AnimalsCells
  185. Lopez Bergami P, Cabeza Meckert P, Kaplan D, Levitus G, Elias F, Quintana F, Van Regenmortel M, Laguens R, Levin MJ. Immunization with recombinant Trypanosoma cruzi ribosomal P2beta protein induces changes in the electrocardiogram of immunized mice. FEMS Immunol Med Microbiol. 1997 May; 18(1):75-85. PMID: 9215590.
    Citations: 7     Fields:    Translation:HumansAnimalsPHPublic Health
  186. Leno C, Berciano J, Combarros O, Sedano C, Alvarez C, Merino J, Quintana F, Martín-Durán R, Rebollo M, Pascual J, et al. Etiologic study of stroke in 95 young adults. Neurologia. 1995 Aug-Sep; 10(7):283-7. PMID: 7576726.
    Citations: 1     Fields:    Translation:Humans
  187. Leno C, Berciano J, Combarros O, Polo JM, Pascual J, Quintana F, Merino J, Sedano C, Martín-Durán R, Alvarez C, et al. A prospective study of stroke in young adults in Cantabria, Spain. Stroke. 1993 Jun; 24(6):792-5. PMID: 8506549.
    Citations: 10     Fields:    Translation:Humans
  188. Ramos A, Quintana F, Díez C, Leno C, Berciano J. CT findings in spinocerebellar degeneration. AJNR Am J Neuroradiol. 1987 Jul-Aug; 8(4):635-40. PMID: 3113200.
    Citations: 9     Fields:    Translation:Humans
  189. Rebollo M, Val JF, Garijo F, Quintana F, Berciano J. Livedo reticularis and cerebrovascular lesions (Sneddon's syndrome). Clinical, radiological and pathological features in eight cases. Brain. 1983 Dec; 106 ( Pt 4):965-79. PMID: 6652469.
    Citations: 18     Fields:    Translation:Humans
  190. Rebollo M, Quintana F, Combarros O, Berciano J. Giant aneurysm of the intracavernous carotid artery and bilateral carotid fibromuscular dysplasia. J Neurol Neurosurg Psychiatry. 1983 Mar; 46(3):284-5. PMID: 6842239.
    Citations: 1     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.