Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Francisco Javier Quintana, Ph.D.

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Overview
overview
The Quintana lab is focused on the characterization of signaling pathways that control the activity of the immune system, with the ultimate goal of identifying novel therapeutic targets and biomarkers for immune-mediated disorders. To this aim, we use genomic and proteomic tools to the study zebrafish, murine and human disease models of inflammation
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Mentoring
current student opportunities
Available: 01/01/21, Expires: 12/31/26

Multiple projects are available to investigate mechanisms of inflammation and neurodegeneration in multiple neurologic diseases, and their regulation by metabolism, the gut flora and environmental factors. Our lab uses advanced genomic tools in combination with animal models (mice and zebrafish) and clinical samples. Experience in animal models, cell culture and/or genomics is required.


Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Giovannoni F, Li Z, Remes-Lenicov F, Dávola ME, Elizalde M, Paletta A, Ashkar AA, Mossman KL, Dugour AV, Figueroa JM, Barquero AA, Ceballos A, Garcia CC, Quintana FJ. AHR signaling is induced by infection with coronaviruses. Nat Commun. 2021 08 26; 12(1):5148. PMID: 34446714.
    Citations:    Fields:    Translation:HumansCells
  2. Quintana FJ, Weiner HL. TrbK controls astrocyte-driven oligodendrocyte copper poisoning. Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32). PMID: 34344829.
    Citations:    Fields:    
  3. Cirac A, Tsaktanis T, Beyer T, Linnerbauer M, Andlauer T, Grummel V, Nirschl L, Loesslein L, Quintana FJ, Hemmer B, Rothhammer V. The Aryl Hydrocarbon Receptor-Dependent TGF-a/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2021 07; 8(5). PMID: 34301821.
    Citations:    Fields:    
  4. Sanmarco LM, Polonio CM, Wheeler MA, Quintana FJ. Functional immune cell-astrocyte interactions. J Exp Med. 2021 Sep 06; 218(9). PMID: 34292315.
    Citations:    Fields:    
  5. Scott BM, Gutiérrez-Vázquez C, Sanmarco LM, da Silva Pereira JA, Li Z, Plasencia A, Hewson P, Cox LM, O'Brien M, Chen SK, Moraes-Vieira PM, Chang BSW, Peisajovich SG, Quintana FJ. Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease. Nat Med. 2021 07; 27(7):1212-1222. PMID: 34183837.
    Citations: 2     Fields:    
  6. Kenison JE, Wang Z, Yang K, Snyder M, Quintana FJ, Sherr DH. The aryl hydrocarbon receptor suppresses immunity to oral squamous cell carcinoma through immune checkpoint regulation. Proc Natl Acad Sci U S A. 2021 May 11; 118(19). PMID: 33941684.
    Citations:    Fields:    
  7. Clark IC, Gutiérrez-Vázquez C, Wheeler MA, Li Z, Rothhammer V, Linnerbauer M, Sanmarco LM, Guo L, Blain M, Zandee SEJ, Chao CC, Batterman KV, Schwabenland M, Lotfy P, Tejeda-Velarde A, Hewson P, Manganeli Polonio C, Shultis MW, Salem Y, Tjon EC, Fonseca-Castro PH, Borucki DM, Alves de Lima K, Plasencia A, Abate AR, Rosene DL, Hodgetts KJ, Prinz M, Antel JP, Prat A, Quintana FJ. Barcoded viral tracing of single-cell interactions in central nervous system inflammation. Science. 2021 04 23; 372(6540). PMID: 33888612.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  8. Clark IC, Mensa B, Ochs CJ, Schmidt NW, Mravic M, Quintana FJ, DeGrado WF, Abate AR. Protein design-scapes generated by microfluidic DNA assembly elucidate domain coupling in the bacterial histidine kinase CpxA. Proc Natl Acad Sci U S A. 2021 03 23; 118(12). PMID: 33723045.
    Citations: 1     Fields:    Translation:Cells
  9. Torti MF, Giovannoni F, Quintana FJ, García CC. The Aryl Hydrocarbon Receptor as a Modulator of Anti-viral Immunity. Front Immunol. 2021; 12:624293. PMID: 33746961.
    Citations:    Fields:    Translation:HumansAnimalsCells
  10. Barroso A, Mahler JV, Fonseca-Castro PH, Quintana FJ. Therapeutic induction of tolerogenic dendritic cells via aryl hydrocarbon receptor signaling. Curr Opin Immunol. 2021 06; 70:33-39. PMID: 33607496.
    Citations:    Fields:    
  11. Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, Bonvento G, Butt AM, Chen WT, Cohen-Salmon M, Cunningham C, Deneen B, De Strooper B, Díaz-Castro B, Farina C, Freeman M, Gallo V, Goldman JE, Goldman SA, Götz M, Gutiérrez A, Haydon PG, Heiland DH, Hol EM, Holt MG, Iino M, Kastanenka KV, Kettenmann H, Khakh BS, Koizumi S, Lee CJ, Liddelow SA, MacVicar BA, Magistretti P, Messing A, Mishra A, Molofsky AV, Murai KK, Norris CM, Okada S, Oliet SHR, Oliveira JF, Panatier A, Parpura V, Pekna M, Pekny M, Pellerin L, Perea G, Pérez-Nievas BG, Pfrieger FW, Poskanzer KE, Quintana FJ, Ransohoff RM, Riquelme-Perez M, Robel S, Rose CR, Rothstein JD, Rouach N, Rowitch DH, Semyanov A, Sirko S, Sontheimer H, Swanson RA, Vitorica J, Wanner IB, Wood LB, Wu J, Zheng B, Zimmer ER, Zorec R, Sofroniew MV, Verkhratsky A. Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci. 2021 03; 24(3):312-325. PMID: 33589835.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  12. Prinz M, Masuda T, Wheeler MA, Quintana FJ. Microglia and Central Nervous System-Associated Macrophages-From Origin to Disease Modulation. Annu Rev Immunol. 2021 04 26; 39:251-277. PMID: 33556248.
    Citations: 1     Fields:    
  13. Barroso A, Mahler JV, Fonseca-Castro PH, Quintana FJ. The aryl hydrocarbon receptor and the gut-brain axis. Cell Mol Immunol. 2021 02; 18(2):259-268. PMID: 33408340.
    Citations: 4     Fields:    
  14. Sanmarco LM, Wheeler MA, Gutiérrez-Vázquez C, Polonio CM, Linnerbauer M, Pinho-Ribeiro FA, Li Z, Giovannoni F, Batterman KV, Scalisi G, Zandee SEJ, Heck ES, Alsuwailm M, Rosene DL, Becher B, Chiu IM, Prat A, Quintana FJ. Gut-licensed IFN?+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes. Nature. 2021 Feb; 590(7846):473-479. PMID: 33408417.
    Citations: 16     Fields:    
  15. Rothhammer V, Kenison JE, Li Z, Tjon E, Takenaka MC, Chao CC, Alves de Lima K, Borucki DM, Kaye J, Quintana FJ. Aryl Hydrocarbon Receptor Activation in Astrocytes by Laquinimod Ameliorates Autoimmune Inflammation in the CNS. Neurol Neuroimmunol Neuroinflamm. 2021 03 04; 8(2). PMID: 33408169.
    Citations:    Fields:    
  16. Levy O, Rothhammer V, Mascanfroni I, Tong Z, Kuai R, De Biasio M, Wang Q, Majid T, Perrault C, Yeste A, Kenison JE, Safaee H, Musabeyezu J, Heinelt M, Milton Y, Kuang H, Lan H, Siders W, Multon MC, Rothblatt J, Massadeh S, Alaamery M, Alhasan AH, Quintana FJ, Karp JM. A cell-based drug delivery platform for treating central nervous system inflammation. J Mol Med (Berl). 2021 05; 99(5):663-671. PMID: 33398468.
    Citations: 1     Fields:    
  17. Giovannoni F, Quintana FJ. SARS-CoV-2-induced lung pathology: AHR as a candidate therapeutic target. Cell Res. 2021 01; 31(1):1-2. PMID: 33262451.
    Citations:    Fields:    Translation:HumansAnimals
  18. Tsaktanis T, Beyer T, Nirschl L, Linnerbauer M, Grummel V, Bussas M, Tjon E, Mühlau M, Korn T, Hemmer B, Quintana FJ, Rothhammer V. Aryl Hydrocarbon Receptor Plasma Agonist Activity Correlates With Disease Activity in Progressive MS. Neurol Neuroimmunol Neuroinflamm. 2021 03; 8(2). PMID: 33361385.
    Citations: 1     Fields:    
  19. Kenison JE, Jhaveri A, Li Z, Khadse N, Tjon E, Tezza S, Nowakowska D, Plasencia A, Stanton VP, Sherr DH, Quintana FJ. Tolerogenic nanoparticles suppress central nervous system inflammation. Proc Natl Acad Sci U S A. 2020 12 15; 117(50):32017-32028. PMID: 33239445.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  20. Sungnak W, Wagner A, Kowalczyk MS, Bod L, Kye YC, Sage PT, Sharpe AH, Sobel RA, Quintana FJ, Rozenblatt-Rosen O, Regev A, Wang C, Yosef N, Kuchroo VK. T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity. J Immunol. 2020 12 15; 205(12):3247-3262. PMID: 33168576.
    Citations:    Fields:    Translation:AnimalsCells
  21. Clark IC, Delley CL, Sun C, Thakur R, Stott SL, Thaploo S, Li Z, Quintana FJ, Abate AR. Targeted Single-Cell RNA and DNA Sequencing With Fluorescence-Activated Droplet Merger. Anal Chem. 2020 11 03; 92(21):14616-14623. PMID: 33049138.
    Citations:    Fields:    Translation:HumansCells
  22. Giovannoni F, Bosch I, Polonio CM, Torti MF, Wheeler MA, Li Z, Romorini L, Rodriguez Varela MS, Rothhammer V, Barroso A, Tjon EC, Sanmarco LM, Takenaka MC, Modaresi SMS, Gutiérrez-Vázquez C, Zanluqui NG, Dos Santos NB, Munhoz CD, Wang Z, Damonte EB, Sherr D, Gehrke L, Peron JPS, Garcia CC, Quintana FJ. Author Correction: AHR is a Zika virus host factor and a candidate target for antiviral therapy. Nat Neurosci. 2020 Oct; 23(10):1307. PMID: 32778795.
    Citations:    Fields:    
  23. Probert L, Quintana FJ, Bar-Or A. Editorial: Update on Translational Neuroimmunology - Research of ISNI 2018. Front Immunol. 2020; 11:2012. PMID: 33101268.
    Citations:    Fields:    Translation:HumansAnimals
  24. Badimon A, Strasburger HJ, Ayata P, Chen X, Nair A, Ikegami A, Hwang P, Chan AT, Graves SM, Uweru JO, Ledderose C, Kutlu MG, Wheeler MA, Kahan A, Ishikawa M, Wang YC, Loh YE, Jiang JX, Surmeier DJ, Robson SC, Junger WG, Sebra R, Calipari ES, Kenny PJ, Eyo UB, Colonna M, Quintana FJ, Wake H, Gradinaru V, Schaefer A. Negative feedback control of neuronal activity by microglia. Nature. 2020 10; 586(7829):417-423. PMID: 32999463.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  25. Mendelsohn AC, Sanmarco LM, Spallanzani RG, Brown D, Quintana FJ, Breton S, Battistone MA. From initial segment to cauda: a regional characterization of mouse epididymal CD11c+ mononuclear phagocytes based on immune phenotype and function. Am J Physiol Cell Physiol. 2020 12 01; 319(6):C997-C1010. PMID: 32991210.
    Citations: 1     Fields:    Translation:AnimalsCells
  26. Linnerbauer M, Wheeler MA, Quintana FJ. Astrocyte Crosstalk in CNS Inflammation. Neuron. 2020 11 25; 108(4):608-622. PMID: 32898475.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  27. Giovannoni F, Quintana FJ. The Role of Astrocytes in CNS Inflammation. Trends Immunol. 2020 09; 41(9):805-819. PMID: 32800705.
    Citations: 32     Fields:    Translation:HumansCells
  28. Giovannoni F, Bosch I, Polonio CM, Torti MF, Wheeler MA, Li Z, Romorini L, Rodriguez Varela MS, Rothhammer V, Barroso A, Tjon EC, Sanmarco LM, Takenaka MC, Modaresi SMS, Gutiérrez-Vázquez C, Zanluqui NG, Dos Santos NB, Munhoz CD, Wang Z, Damonte EB, Sherr D, Gehrke L, Peron JPS, Garcia CC, Quintana FJ. AHR is a Zika virus host factor and a candidate target for antiviral therapy. Nat Neurosci. 2020 08; 23(8):939-951. PMID: 32690969.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  29. Xiao S, Bod L, Pochet N, Kota SB, Hu D, Madi A, Kilpatrick J, Shi J, Ho A, Zhang H, Sobel R, Weiner HL, Strom TB, Quintana FJ, Joller N, Kuchroo VK. Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation. Cell Rep. 2020 07 14; 32(2):107892. PMID: 32668241.
    Citations: 4     Fields:    Translation:AnimalsCells
  30. Kadowaki A, Quintana FJ. The Gut-CNS Axis in Multiple Sclerosis. Trends Neurosci. 2020 08; 43(8):622-634. PMID: 32650957.
    Citations: 12     Fields:    Translation:Humans
  31. Alaamery M, Albesher N, Aljawini N, Alsuwailm M, Massadeh S, Wheeler MA, Chao CC, Quintana FJ. Role of sphingolipid metabolism in neurodegeneration. J Neurochem. 2021 Jul; 158(1):25-35. PMID: 32402091.
    Citations: 3     Fields:    
  32. Liu A, Shi FD, Cohen IR, Castaldo G, Matarese G, Quintana FJ, La Cava A. DNA vaccine encoding heat shock protein 90 protects from murine lupus. Arthritis Res Ther. 2020 06 22; 22(1):152. PMID: 32571400.
    Citations:    Fields:    Translation:Animals
  33. Sádaba MC, Rothhammer V, Muñoz Ú, Sebal C, Escudero E, Kivisäkk P, Garcia Sanchez MI, Izquierdo G, Hauser SL, Baranzini SE, Oksenberg JR, Álvarez-Lafuente R, Bakshi R, Weiner HL, Quintana FJ. Serum antibodies to phosphatidylcholine in MS. Neurol Neuroimmunol Neuroinflamm. 2020 07; 7(4). PMID: 32518205.
    Citations:    Fields:    Translation:Humans
  34. Morianos I, Trochoutsou AI, Papadopoulou G, Semitekolou M, Banos A, Konstantopoulos D, Manousopoulou A, Kapasa M, Wei P, Lomenick B, Belaidi E, Kalamatas T, Karageorgiou K, Doskas T, Sallusto F, Pan F, Garbis SD, Quintana FJ, Xanthou G. Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-a-dependent pathways. Proc Natl Acad Sci U S A. 2020 06 02; 117(22):12269-12280. PMID: 32409602.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  35. Gevaert O, Nabian M, Bakr S, Everaert C, Shinde J, Manukyan A, Liefeld T, Tabor T, Xu J, Lupberger J, Haas BJ, Baumert TF, Hernaez M, Reich M, Quintana FJ, Uhlmann EJ, Krichevsky AM, Mesirov JP, Carey V, Pochet N. Imaging-AMARETTO: An Imaging Genomics Software Tool to Interrogate Multiomics Networks for Relevance to Radiography and Histopathology Imaging Biomarkers of Clinical Outcomes. JCO Clin Cancer Inform. 2020 05; 4:421-435. PMID: 32383980.
    Citations: 3     Fields:    Translation:Humans
  36. Kadowaki A, Quintana FJ. The NLRP3 inflammasome in progressive multiple sclerosis. Brain. 2020 05 01; 143(5):1286-1288. PMID: 32438410.
    Citations:    Fields:    Translation:Humans
  37. Liu A, Ferretti C, Shi FD, Cohen IR, Quintana FJ, La Cava A. DNA Vaccination With Hsp70 Protects Against Systemic Lupus Erythematosus in (NZB × NZW)F1 Mice. Arthritis Rheumatol. 2020 06; 72(6):997-1002. PMID: 31943822.
    Citations: 3     Fields:    Translation:Animals
  38. Giovannoni F, Li Z, Garcia CC, Quintana FJ. A potential role for AHR in SARS-CoV-2 pathology. Res Sq. 2020 Apr 27. PMID: 32702728.
    Citations: 1     
  39. Wheeler MA, Clark IC, Tjon EC, Li Z, Zandee SEJ, Couturier CP, Watson BR, Scalisi G, Alkwai S, Rothhammer V, Rotem A, Heyman JA, Thaploo S, Sanmarco LM, Ragoussis J, Weitz DA, Petrecca K, Moffitt JR, Becher B, Antel JP, Prat A, Quintana FJ. MAFG-driven astrocytes promote CNS inflammation. Nature. 2020 02; 578(7796):593-599. PMID: 32051591.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  40. Antel JP, Becher B, Ludwin SK, Prat A, Quintana FJ. Glial Cells as Regulators of Neuroimmune Interactions in the Central Nervous System. J Immunol. 2020 01 15; 204(2):251-255. PMID: 31907266.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  41. Chao CC, Gutiérrez-Vázquez C, Rothhammer V, Mayo L, Wheeler MA, Tjon EC, Zandee SEJ, Blain M, de Lima KA, Takenaka MC, Avila-Pacheco J, Hewson P, Liu L, Sanmarco LM, Borucki DM, Lipof GZ, Trauger SA, Clish CB, Antel JP, Prat A, Quintana FJ. Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS. Cell. 2019 12 12; 179(7):1483-1498.e22. PMID: 31813625.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  42. Araujo LP, Maricato JT, Guereschi MG, Takenaka MC, Nascimento VM, de Melo FM, Quintana FJ, Brum PC, Basso AS. The Sympathetic Nervous System Mitigates CNS Autoimmunity via ß2-Adrenergic Receptor Signaling in Immune Cells. Cell Rep. 2019 Sep 17; 28(12):3120-3130.e5. PMID: 31533035.
    Citations: 9     Fields:    Translation:AnimalsCells
  43. Takenaka MC, Gabriely G, Rothhammer V, Mascanfroni ID, Wheeler MA, Chao CC, Gutiérrez-Vázquez C, Kenison J, Tjon EC, Barroso A, Vandeventer T, de Lima KA, Rothweiler S, Mayo L, Ghannam S, Zandee S, Healy L, Sherr D, Farez MF, Prat A, Antel J, Reardon DA, Zhang H, Robson SC, Getz G, Weiner HL, Quintana FJ. Author Correction: Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci. 2019 Sep; 22(9):1533. PMID: 31197266.
    Citations: 1     Fields:    
  44. Sanmarco LM, Quintana FJ. Meningeal Memories of Viral Infection. Trends Neurosci. 2019 08; 42(8):513-514. PMID: 31253444.
    Citations: 1     Fields:    Translation:HumansCells
  45. Gabriely G, Quintana FJ. Role of AHR in the control of GBM-associated myeloid cells. Semin Cancer Biol. 2020 08; 64:13-18. PMID: 31128300.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  46. Takenaka MC, Gabriely G, Rothhammer V, Mascanfroni ID, Wheeler MA, Chao CC, Gutiérrez-Vázquez C, Kenison J, Tjon EC, Barroso A, Vandeventer T, de Lima KA, Rothweiler S, Mayo L, Ghannam S, Zandee S, Healy L, Sherr D, Farez MF, Prat A, Antel J, Reardon DA, Zhang H, Robson SC, Getz G, Weiner HL, Quintana FJ. Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci. 2019 05; 22(5):729-740. PMID: 30962630.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  47. Ambrosio LF, Insfran C, Volpini X, Acosta Rodriguez E, Serra HM, Quintana FJ, Cervi L, Motrán CC. Role of Aryl Hydrocarbon Receptor (AhR) in the Regulation of Immunity and Immunopathology During Trypanosoma cruzi Infection. Front Immunol. 2019; 10:631. PMID: 30984194.
    Citations: 5     Fields:    Translation:AnimalsCells
  48. Rothhammer V, Quintana FJ. The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease. Nat Rev Immunol. 2019 03; 19(3):184-197. PMID: 30718831.
    Citations: 154     Fields:    Translation:HumansAnimalsCells
  49. Hemond CC, Healy BC, Tauhid S, Mazzola MA, Quintana FJ, Gandhi R, Weiner HL, Bakshi R. MRI phenotypes in MS: Longitudinal changes and miRNA signatures. Neurol Neuroimmunol Neuroinflamm. 2019 03; 6(2):e530. PMID: 30800720.
    Citations: 8     Fields:    Translation:Humans
  50. Quintana FJ. Myeloid cells in the central nervous system: So similar, yet so different. Sci Immunol. 2019 02 08; 4(32). PMID: 30737356.
    Citations: 2     Fields:    Translation:AnimalsCells
  51. Wheeler MA, Jaronen M, Covacu R, Zandee SEJ, Scalisi G, Rothhammer V, Tjon EC, Chao CC, Kenison JE, Blain M, Rao VTS, Hewson P, Barroso A, Gutiérrez-Vázquez C, Prat A, Antel JP, Hauser R, Quintana FJ. Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation. Cell. 2019 01 24; 176(3):581-596.e18. PMID: 30661753.
    Citations: 37     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  52. Starossom SC, Campo Garcia J, Woelfle T, Romero-Suarez S, Olah M, Watanabe F, Cao L, Yeste A, Tukker JJ, Quintana FJ, Imitola J, Witzel F, Schmitz D, Morkel M, Paul F, Infante-Duarte C, Khoury SJ. Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation. Nat Commun. 2019 01 15; 10(1):217. PMID: 30644388.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  53. Wheeler MA, Quintana FJ. Regulation of Astrocyte Functions in Multiple Sclerosis. Cold Spring Harb Perspect Med. 2019 01 02; 9(1). PMID: 29358321.
    Citations: 24     Fields:    Translation:HumansCells
  54. Quintana FJ. Astrocytes play a crucial role in the formation and evolution of MS lesions - Commentary. Mult Scler. 2019 01; 25(1):19-20. PMID: 30136890.
    Citations: 1     Fields:    Translation:HumansCells
  55. Xie A, Robles RJ, Mukherjee S, Zhang H, Feldbrügge L, Csizmadia E, Wu Y, Enjyoji K, Moss AC, Otterbein LE, Quintana FJ, Robson SC, Longhi MS. HIF-1a-induced xenobiotic transporters promote Th17 responses in Crohn's disease. J Autoimmun. 2018 11; 94:122-133. PMID: 30098863.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  56. Dossi DE, Chaves H, Heck ES, Rodriguez Murúa S, Ventrice F, Bakshi R, Quintana FJ, Correale J, Farez MF. Effects of Systolic Blood Pressure on Brain Integrity in Multiple Sclerosis. Front Neurol. 2018; 9:487. PMID: 29988562.
    Citations:    
  57. Rothhammer V, Borucki DM, Tjon EC, Takenaka MC, Chao CC, Ardura-Fabregat A, de Lima KA, Gutiérrez-Vázquez C, Hewson P, Staszewski O, Blain M, Healy L, Neziraj T, Borio M, Wheeler M, Dragin LL, Laplaud DA, Antel J, Alvarez JI, Prinz M, Quintana FJ. Microglial control of astrocytes in response to microbial metabolites. Nature. 2018 05; 557(7707):724-728. PMID: 29769726.
    Citations: 191     Fields:    Translation:HumansAnimalsCells
  58. Rothhammer V, Borucki DM, Kenison JE, Hewson P, Wang Z, Bakshi R, Sherr DH, Quintana FJ. Detection of aryl hydrocarbon receptor agonists in human samples. Sci Rep. 2018 03 21; 8(1):4970. PMID: 29563571.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  59. Dolciami D, Gargaro M, Cerra B, Scalisi G, Bagnoli L, Servillo G, Fazia MAD, Puccetti P, Quintana FJ, Fallarino F, Macchiarulo A. Binding Mode and Structure-Activity Relationships of ITE as an Aryl Hydrocarbon Receptor (AhR) Agonist. ChemMedChem. 2018 02 06; 13(3):270-279. PMID: 29266750.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  60. Gutiérrez-Vázquez C, Quintana FJ. Regulation of the Immune Response by the Aryl Hydrocarbon Receptor. Immunity. 2018 01 16; 48(1):19-33. PMID: 29343438.
    Citations: 161     Fields:    Translation:HumansAnimalsCells
  61. Zorrilla-Zubilete MA, Yeste A, Quintana FJ, Toiber D, Mostoslavsky R, Silberman DM. Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6. J Neurochem. 2018 01; 144(2):128-138. PMID: 29049850.
    Citations: 11     Fields:    Translation:AnimalsCells
  62. Quintana FJ, Prinz M. A gut feeling about multiple sclerosis. Proc Natl Acad Sci U S A. 2017 10 03; 114(40):10528-10529. PMID: 28973867.
    Citations: 3     Fields:    Translation:Humans
  63. Quintana FJ. Astrocytes to the rescue! Glia limitans astrocytic endfeet control CNS inflammation. J Clin Invest. 2017 Aug 01; 127(8):2897-2899. PMID: 28737511.
    Citations: 12     Fields:    Translation:AnimalsCells
  64. Nirschl CJ, Suárez-Fariñas M, Izar B, Prakadan S, Dannenfelser R, Tirosh I, Liu Y, Zhu Q, Devi KSP, Carroll SL, Chau D, Rezaee M, Kim TG, Huang R, Fuentes-Duculan J, Song-Zhao GX, Gulati N, Lowes MA, King SL, Quintana FJ, Lee YS, Krueger JG, Sarin KY, Yoon CH, Garraway L, Regev A, Shalek AK, Troyanskaya O, Anandasabapathy N. IFN?-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment. Cell. 2017 Jun 29; 170(1):127-141.e15. PMID: 28666115.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  65. Rothhammer V, Borucki DM, Garcia Sanchez MI, Mazzola MA, Hemond CC, Regev K, Paul A, Kivisäkk P, Bakshi R, Izquierdo G, Weiner HL, Quintana FJ. Dynamic regulation of serum aryl hydrocarbon receptor agonists in MS. Neurol Neuroimmunol Neuroinflamm. 2017 Jul; 4(4):e359. PMID: 28642887.
    Citations: 16     Fields:    
  66. Wheeler MA, Rothhammer V, Quintana FJ. Control of immune-mediated pathology via the aryl hydrocarbon receptor. J Biol Chem. 2017 07 28; 292(30):12383-12389. PMID: 28615443.
    Citations: 27     Fields:    Translation:HumansAnimals
  67. Longhi MS, Vuerich M, Kalbasi A, Kenison JE, Yeste A, Csizmadia E, Vaughn B, Feldbrugge L, Mitsuhashi S, Wegiel B, Otterbein L, Moss A, Quintana FJ, Robson SC. Bilirubin suppresses Th17 immunity in colitis by upregulating CD39. JCI Insight. 2017 May 04; 2(9). PMID: 28469075.
    Citations: 23     Fields:    
  68. Gabriely G, Wheeler MA, Takenaka MC, Quintana FJ. Role of AHR and HIF-1a in Glioblastoma Metabolism. Trends Endocrinol Metab. 2017 06; 28(6):428-436. PMID: 28318896.
    Citations: 26     Fields:    Translation:Humans
  69. Rothhammer V, Kenison JE, Tjon E, Takenaka MC, de Lima KA, Borucki DM, Chao CC, Wilz A, Blain M, Healy L, Antel J, Quintana FJ. Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation. Proc Natl Acad Sci U S A. 2017 02 21; 114(8):2012-2017. PMID: 28167760.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  70. Kim G, Chu R, Yousuf F, Tauhid S, Stazzone L, Houtchens MK, Stankiewicz JM, Severson C, Kimbrough D, Quintana FJ, Chitnis T, Weiner HL, Healy BC, Bakshi R. Sample size requirements for one-year treatment effects using deep gray matter volume from 3T MRI in progressive forms of multiple sclerosis. Int J Neurosci. 2017 Nov; 127(11):971-980. PMID: 28100092.
    Citations: 5     Fields:    Translation:Humans
  71. Quintana FJ. Dendritic cells in autoimmunity, infections, and cancer. Semin Immunopathol. 2017 02; 39(2):97-98. PMID: 28093619.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  72. Quintana FJ. Old dog, new tricks: IL-6 cluster signaling promotes pathogenic TH17 cell differentiation. Nat Immunol. 2016 12 16; 18(1):8-10. PMID: 27984572.
    Citations: 9     Fields:    Translation:AnimalsCells
  73. Goettel JA, Gandhi R, Kenison JE, Yeste A, Murugaiyan G, Sambanthamoorthy S, Griffith AE, Patel B, Shouval DS, Weiner HL, Snapper SB, Quintana FJ. AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice. Cell Rep. 2016 10 25; 17(5):1318-1329. PMID: 27783946.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  74. Kuhn C, Rezende RM, da Cunha AP, Valette F, Quintana FJ, Chatenoud L, Weiner HL. Mucosal administration of CD3-specific monoclonal antibody inhibits diabetes in NOD mice and in a preclinical mouse model transgenic for the CD3 epsilon chain. J Autoimmun. 2017 01; 76:115-122. PMID: 27745778.
    Citations: 4     Fields:    Translation:AnimalsCells
  75. Rothhammer V, Quintana FJ. Environmental control of autoimmune inflammation in the central nervous system. Curr Opin Immunol. 2016 12; 43:46-53. PMID: 27710839.
    Citations: 27     Fields:    Translation:HumansAnimalsPHPublic Health
  76. Shouval DS, Biswas A, Kang YH, Griffith AE, Konnikova L, Mascanfroni ID, Redhu NS, Frei SM, Field M, Doty AL, Goldsmith JD, Bhan AK, Loizides A, Weiss B, Yerushalmi B, Yanagi T, Lui X, Quintana FJ, Muise AM, Klein C, Horwitz BH, Glover SC, Bousvaros A, Snapper SB. Interleukin 1ß Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency. Gastroenterology. 2016 12; 151(6):1100-1104. PMID: 27693323.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  77. Takenaka MC, Quintana FJ. Tolerogenic dendritic cells. Semin Immunopathol. 2017 02; 39(2):113-120. PMID: 27646959.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  78. Poutiainen P, Jaronen M, Quintana FJ, Brownell AL. Precision Medicine in Multiple Sclerosis: Future of PET Imaging of Inflammation and Reactive Astrocytes. Front Mol Neurosci. 2016; 9:85. PMID: 27695400.
    Citations: 9     
  79. Farez MF, Calandri IL, Correale J, Quintana FJ. Anti-inflammatory effects of melatonin in multiple sclerosis. Bioessays. 2016 10; 38(10):1016-26. PMID: 27561251.
    Citations: 10     Fields:    Translation:HumansAnimals
  80. Jangi S, Gandhi R, Cox LM, Li N, von Glehn F, Yan R, Patel B, Mazzola MA, Liu S, Glanz BL, Cook S, Tankou S, Stuart F, Melo K, Nejad P, Smith K, Topçuolu BD, Holden J, Kivisäkk P, Chitnis T, De Jager PL, Quintana FJ, Gerber GK, Bry L, Weiner HL. Alterations of the human gut microbiome in multiple sclerosis. Nat Commun. 2016 06 28; 7:12015. PMID: 27352007.
    Citations: 292     Fields:    Translation:HumansCells
  81. Quintana FJ, VanHook AM. Science Signaling Podcast for 21 June 2016: Nanoparticles to treat type 1 diabetes. Sci Signal. 2016 06 21; 9(433):c15. PMID: 27330187.
    Citations:    Fields:    Translation:HumansAnimalsCells
  82. Yeste A, Takenaka MC, Mascanfroni ID, Nadeau M, Kenison JE, Patel B, Tukpah AM, Babon JA, DeNicola M, Kent SC, Pozo D, Quintana FJ. Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2. Sci Signal. 2016 06 21; 9(433):ra61. PMID: 27330188.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  83. Fernández D, Flores-Santibáñez F, Neira J, Osorio-Barrios F, Tejón G, Nuñez S, Hidalgo Y, Fuenzalida MJ, Meza D, Ureta G, Lladser A, Pacheco R, Acuña-Castillo C, Guixé V, Quintana FJ, Bono MR, Rosemblatt M, Sauma D. Purinergic Signaling as a Regulator of Th17 Cell Plasticity. PLoS One. 2016; 11(6):e0157889. PMID: 27322617.
    Citations: 13     Fields:    Translation:AnimalsCells
  84. Sisirak V, Sally B, D'Agati V, Martinez-Ortiz W, Özçakar ZB, David J, Rashidfarrokhi A, Yeste A, Panea C, Chida AS, Bogunovic M, Ivanov II, Quintana FJ, Sanz I, Elkon KB, Tekin M, Yalçinkaya F, Cardozo TJ, Clancy RM, Buyon JP, Reizis B. Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity. Cell. 2016 Jun 30; 166(1):88-101. PMID: 27293190.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  85. Mayo L, Cunha AP, Madi A, Beynon V, Yang Z, Alvarez JI, Prat A, Sobel RA, Kobzik L, Lassmann H, Quintana FJ, Weiner HL. IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation. Brain. 2016 07; 139(Pt 7):1939-57. PMID: 27246324.
    Citations: 37     Fields:    Translation:AnimalsCells
  86. Takenaka MC, Robson S, Quintana FJ. Regulation of the T Cell Response by CD39. Trends Immunol. 2016 07; 37(7):427-439. PMID: 27236363.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  87. Rothhammer V, Mascanfroni ID, Bunse L, Takenaka MC, Kenison JE, Mayo L, Chao CC, Patel B, Yan R, Blain M, Alvarez JI, Kébir H, Anandasabapathy N, Izquierdo G, Jung S, Obholzer N, Pochet N, Clish CB, Prinz M, Prat A, Antel J, Quintana FJ. Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Nat Med. 2016 06; 22(6):586-97. PMID: 27158906.
    Citations: 293     Fields:    Translation:HumansAnimalsCells
  88. Covacu R, Philip H, Jaronen M, Almeida J, Kenison JE, Darko S, Chao CC, Yaari G, Louzoun Y, Carmel L, Douek DC, Efroni S, Quintana FJ. System-wide Analysis of the T Cell Response. Cell Rep. 2016 Mar 22; 14(11):2733-44. PMID: 26972015.
    Citations: 16     Fields:    Translation:AnimalsCells
  89. Bakshi R, Yeste A, Patel B, Tauhid S, Tummala S, Rahbari R, Chu R, Regev K, Kivisäkk P, Weiner HL, Quintana FJ. Serum lipid antibodies are associated with cerebral tissue damage in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2016 Apr; 3(2):e200. PMID: 26894204.
    Citations: 16     Fields:    
  90. Caballero-Hernandez D, Toscano MG, Cejudo-Guillen M, Garcia-Martin ML, Lopez S, Franco JM, Quintana FJ, Roodveldt C, Pozo D. The 'Omics' of Amyotrophic Lateral Sclerosis. Trends Mol Med. 2016 Jan; 22(1):53-67. PMID: 26691296.
    Citations: 5     Fields:    Translation:Humans
  91. Takenaka MC, Quintana FJ. Achieving Tolerance with Perforin-Secreting Dendritic Cells. Trends Mol Med. 2016 Jan; 22(1):3-4. PMID: 26700492.
    Citations: 1     Fields:    Translation:AnimalsCells
  92. Takenaka MC, Araujo LP, Maricato JT, Nascimento VM, Guereschi MG, Rezende RM, Quintana FJ, Basso AS. Norepinephrine Controls Effector T Cell Differentiation through ß2-Adrenergic Receptor-Mediated Inhibition of NF-?B and AP-1 in Dendritic Cells. J Immunol. 2016 Jan 15; 196(2):637-44. PMID: 26663782.
    Citations: 22     Fields:    Translation:AnimalsCells
  93. Farez MF, Mascanfroni ID, Méndez-Huergo SP, Yeste A, Murugaiyan G, Garo LP, Balbuena Aguirre ME, Patel B, Ysrraelit MC, Zhu C, Kuchroo VK, Rabinovich GA, Quintana FJ, Correale J. Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses. Cell. 2015 Sep 10; 162(6):1338-52. PMID: 26359987.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  94. Rothhammer V, Quintana FJ. Role of astrocytes and microglia in central nervous system inflammation. Introduction. Semin Immunopathol. 2015 Nov; 37(6):575-6. PMID: 26271223.
    Citations: 5     Fields:    Translation:HumansCells
  95. Rothhammer V, Quintana FJ. Control of autoimmune CNS inflammation by astrocytes. Semin Immunopathol. 2015 Nov; 37(6):625-38. PMID: 26223505.
    Citations: 60     Fields:    Translation:HumansCells
  96. Mascanfroni ID, Takenaka MC, Yeste A, Patel B, Wu Y, Kenison JE, Siddiqui S, Basso AS, Otterbein LE, Pardoll DM, Pan F, Priel A, Clish CB, Robson SC, Quintana FJ. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-a. Nat Med. 2015 Jun; 21(6):638-46. PMID: 26005855.
    Citations: 167     Fields:    Translation:HumansAnimalsCells
  97. Goettel JA, Biswas S, Lexmond WS, Yeste A, Passerini L, Patel B, Yang S, Sun J, Ouahed J, Shouval DS, McCann KJ, Horwitz BH, Mathis D, Milford EL, Notarangelo LD, Roncarolo MG, Fiebiger E, Marasco WA, Bacchetta R, Quintana FJ, Pai SY, Klein C, Muise AM, Snapper SB. Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3. Blood. 2015 Jun 18; 125(25):3886-95. PMID: 25833964.
    Citations: 16     Fields:    Translation:HumansAnimals
  98. Quintana FJ, Patel B, Yeste A, Nyirenda M, Kenison J, Rahbari R, Fetco D, Hussain M, O'Mahony J, Magalhaes S, McGowan M, Johnson T, Rajasekharan S, Narayanan S, Arnold DL, Weiner HL, Banwell B, Bar-Or A. Epitope spreading as an early pathogenic event in pediatric multiple sclerosis. Neurology. 2014 Dec 09; 83(24):2219-26. PMID: 25381299.
    Citations: 16     Fields:    Translation:Humans
  99. Yeste A, Quintana FJ. [The microprobes of antigens for studying of autoimmune diseases]. Klin Lab Diagn. 2014 Nov; 59(11):10-7. PMID: 25850238.
    Citations:    Fields:    Translation:HumansCells
  100. Jaronen M, Quintana FJ. Immunological Relevance of the Coevolution of IDO1 and AHR. Front Immunol. 2014; 5:521. PMID: 25368620.
    Citations: 30     Fields:    
  101. Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivisäkk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, Quintana FJ. Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Nat Med. 2014 Oct; 20(10):1147-56. PMID: 25216636.
    Citations: 129     Fields:    Translation:HumansAnimalsCells
  102. Quintana FJ, Yeste A, Mascanfroni ID. Role and therapeutic value of dendritic cells in central nervous system autoimmunity. Cell Death Differ. 2015 Feb; 22(2):215-24. PMID: 25168240.
    Citations: 16     Fields:    Translation:HumansCellsPHPublic Health
  103. Farez MF, Fiol MP, Gaitán MI, Quintana FJ, Correale J. Sodium intake is associated with increased disease activity in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2015 Jan; 86(1):26-31. PMID: 25168393.
    Citations: 67     Fields:    Translation:Humans
  104. Quintana FJ. LeA(H)Rning self-control. Cell Res. 2014 Oct; 24(10):1155-6. PMID: 25060701.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  105. Quinn DM, Williams MK, Quintana F, Gaskins JL, Overstreet NM, Pishori A, Earnshaw VA, Perez G, Chaudoir SR. Examining effects of anticipated stigma, centrality, salience, internalization, and outness on psychological distress for people with concealable stigmatized identities. PLoS One. 2014; 9(5):e96977. PMID: 24817189.
    Citations: 27     Fields:    Translation:Humans
  106. Yeste A, Mascanfroni ID, Nadeau M, Burns EJ, Tukpah AM, Santiago A, Wu C, Patel B, Kumar D, Quintana FJ. IL-21 induces IL-22 production in CD4+ T cells. Nat Commun. 2014 May 06; 5:3753. PMID: 24796415.
    Citations: 55     Fields:    Translation:HumansCells
  107. Shouval DS, Biswas A, Goettel JA, McCann K, Conaway E, Redhu NS, Mascanfroni ID, Al Adham Z, Lavoie S, Ibourk M, Nguyen DD, Samsom JN, Escher JC, Somech R, Weiss B, Beier R, Conklin LS, Ebens CL, Santos FG, Ferreira AR, Sherlock M, Bhan AK, Müller W, Mora JR, Quintana FJ, Klein C, Muise AM, Horwitz BH, Snapper SB. Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity. 2014 May 15; 40(5):706-19. PMID: 24792912.
    Citations: 177     Fields:    Translation:HumansAnimalsCells
  108. Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, Kuchroo VK. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity. 2014 Apr 17; 40(4):569-81. PMID: 24745333.
    Citations: 231     Fields:    Translation:AnimalsCells
  109. Longhi MS, Moss A, Bai A, Wu Y, Huang H, Cheifetz A, Quintana FJ, Robson SC. Characterization of human CD39+ Th17 cells with suppressor activity and modulation in inflammatory bowel disease. PLoS One. 2014; 9(2):e87956. PMID: 24505337.
    Citations: 32     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  110. Moraes-Vieira PM, Larocca RA, Bassi EJ, Peron JP, Andrade-Oliveira V, Wasinski F, Araujo R, Thornley T, Quintana FJ, Basso AS, Strom TB, Câmara NO. Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells. Eur J Immunol. 2014 Mar; 44(3):794-806. PMID: 24271843.
    Citations: 31     Fields:    Translation:AnimalsCells
  111. Quintana FJ, Pérez-Sánchez S, Farez MF. [Immunopathology of multiple sclerosis]. Medicina (B Aires). 2014; 74(5):404-10. PMID: 25347906.
    Citations: 1     Fields:    Translation:HumansCells
  112. Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK. Corrigendum: Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat Immunol. 2013 Dec 18; 15(1):109. PMID: 24352327.
    Citations:    
  113. Pot C, Quintana FJ, Kuchroo VK. Fine tuning of the immune response by the Aryl Hydrocarbon Receptor. Semin Immunopathol. 2013 Nov; 35(6):613. PMID: 24104867.
    Citations:    
  114. Kivisäkk P, Healy BC, Francois K, Gandhi R, Gholipour T, Egorova S, Sevdalinova V, Quintana F, Chitnis T, Weiner HL, Khoury SJ. Evaluation of circulating osteopontin levels in an unselected cohort of patients with multiple sclerosis: relevance for biomarker development. Mult Scler. 2014 Apr; 20(4):438-44. PMID: 24005026.
    Citations: 13     Fields:    Translation:Humans
  115. Quintana FJ. Regulation of central nervous system autoimmunity by the aryl hydrocarbon receptor. Semin Immunopathol. 2013 Nov; 35(6):627-35. PMID: 23999753.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  116. Mascanfroni ID, Yeste A, Vieira SM, Burns EJ, Patel B, Sloma I, Wu Y, Mayo L, Ben-Hamo R, Efroni S, Kuchroo VK, Robson SC, Quintana FJ. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39. Nat Immunol. 2013 Oct; 14(10):1054-63. PMID: 23995234.
    Citations: 135     Fields:    Translation:AnimalsCells
  117. Quintana FJ, Sherr DH. Aryl hydrocarbon receptor control of adaptive immunity. Pharmacol Rev. 2013; 65(4):1148-61. PMID: 23908379.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  118. Gandhi R, Healy B, Gholipour T, Egorova S, Musallam A, Hussain MS, Nejad P, Patel B, Hei H, Khoury S, Quintana F, Kivisakk P, Chitnis T, Weiner HL. Circulating microRNAs as biomarkers for disease staging in multiple sclerosis. Ann Neurol. 2013 Jun; 73(6):729-40. PMID: 23494648.
    Citations: 84     Fields:    Translation:Humans
  119. Quintana FJ. Nanoparticles for the induction of antigen-specific Tregs. Immunotherapy. 2013 May; 5(5):437-40. PMID: 23638737.
    Citations: 5     Fields:    Translation:HumansCells
  120. Ahmed ST, Akirav E, Bradshaw E, Buckner J, McKinney E, Quintana FJ, Waldron-Lynch F, Nepom J. Immunological biomarkers: catalysts for translational advances in autoimmune diabetes. Clin Exp Immunol. 2013 May; 172(2):178-85. PMID: 23574315.
    Citations: 3     Fields:    Translation:HumansCells
  121. Bransburg-Zabary S, Kenett DY, Dar G, Madi A, Merbl Y, Quintana FJ, Tauber AI, Cohen IR, Ben-Jacob E. Individual and meta-immune networks. Phys Biol. 2013 Apr; 10(2):025003. PMID: 23492831.
    Citations: 4     Fields:    Translation:Humans
  122. Yeste A, Quintana FJ. Antigen microarrays for the study of autoimmune diseases. Clin Chem. 2013 Jul; 59(7):1036-44. PMID: 23487172.
    Citations: 12     Fields:    Translation:Humans
  123. Quintana FJ. The aryl hydrocarbon receptor: a molecular pathway for the environmental control of the immune response. Immunology. 2013 Mar; 138(3):183-9. PMID: 23190340.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  124. Moraes-Vieira PM, Bassi EJ, Larocca RA, Castoldi A, Burghos M, Lepique AP, Quintana FJ, Araujo RC, Basso AS, Strom TB, Câmara NO. Leptin deficiency modulates allograft survival by favoring a Th2 and a regulatory immune profile. [corrected]. Am J Transplant. 2013 Jan; 13(1):36-44. PMID: 23016759.
    Citations: 16     Fields:    Translation:AnimalsCells
  125. Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK. Induction and molecular signature of pathogenic TH17 cells. Nat Immunol. 2012 Oct; 13(10):991-9. PMID: 22961052.
    Citations: 427     Fields:    Translation:HumansAnimalsCells
  126. Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK. Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):12105-10. PMID: 22773818.
    Citations: 62     Fields:    Translation:AnimalsCells
  127. Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK. Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat Immunol. 2012 Jul 01; 13(8):770-7. PMID: 22751139.
    Citations: 115     Fields:    Translation:AnimalsCells
  128. Mayo L, Quintana FJ, Weiner HL. The innate immune system in demyelinating disease. Immunol Rev. 2012 Jul; 248(1):170-87. PMID: 22725961.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  129. Beynon V, Quintana FJ, Weiner HL. Activated human CD4+CD45RO+ memory T-cells indirectly inhibit NLRP3 inflammasome activation through downregulation of P2X7R signalling. PLoS One. 2012; 7(6):e39576. PMID: 22768094.
    Citations: 13     Fields:    Translation:HumansCells
  130. Yeste A, Nadeau M, Burns EJ, Weiner HL, Quintana FJ. Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11270-5. PMID: 22745170.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  131. Quintana FJ, Yeste A, Weiner HL, Covacu R. Lipids and lipid-reactive antibodies as biomarkers for multiple sclerosis. J Neuroimmunol. 2012 Jul 15; 248(1-2):53-7. PMID: 22579051.
    Citations: 22     Fields:    Translation:HumansAnimals
  132. Quintana FJ, Farez MF, Izquierdo G, Lucas M, Cohen IR, Weiner HL. Antigen microarrays identify CNS-produced autoantibodies in RRMS. Neurology. 2012 Feb 21; 78(8):532-9. PMID: 22262743.
    Citations: 31     Fields:    Translation:HumansCells
  133. Liu SM, Sutherland AP, Zhang Z, Rainbow DB, Quintana FJ, Paterson AM, Sharpe AH, Oukka M, Wicker LS, Kuchroo VK. Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity. J Immunol. 2012 Jan 01; 188(1):155-62. PMID: 22124121.
    Citations: 12     Fields:    Translation:AnimalsCells
  134. Cassani B, Villablanca EJ, Quintana FJ, Love PE, Lacy-Hulbert A, Blaner WS, Sparwasser T, Snapper SB, Weiner HL, Mora JR. Gut-tropic T cells that express integrin a4ß7 and CCR9 are required for induction of oral immune tolerance in mice. Gastroenterology. 2011 Dec; 141(6):2109-18. PMID: 21925467.
    Citations: 67     Fields:    Translation:AnimalsCells
  135. Wu HY, Quintana FJ, da Cunha AP, Dake BT, Koeglsperger T, Starossom SC, Weiner HL. In vivo induction of Tr1 cells via mucosal dendritic cells and AHR signaling. PLoS One. 2011; 6(8):e23618. PMID: 21886804.
    Citations: 51     Fields:    Translation:AnimalsCells
  136. Weiner HL, da Cunha AP, Quintana F, Wu H. Oral tolerance. Immunol Rev. 2011 May; 241(1):241-59. PMID: 21488901.
    Citations: 212     Fields:    Translation:HumansAnimalsCells
  137. Madi A, Kenett DY, Bransburg-Zabary S, Merbl Y, Quintana FJ, Tauber AI, Cohen IR, Ben-Jacob E. Network theory analysis of antibody-antigen reactivity data: the immune trees at birth and adulthood. PLoS One. 2011 Mar 08; 6(3):e17445. PMID: 21408156.
    Citations: 8     Fields:    Translation:Humans
  138. Madi A, Kenett DY, Bransburg-Zabary S, Merbl Y, Quintana FJ, Boccaletti S, Tauber AI, Cohen IR, Ben-Jacob E. Analyses of antigen dependency networks unveil immune system reorganization between birth and adulthood. Chaos. 2011 Mar; 21(1):016109. PMID: 21456851.
    Citations: 5     Fields:    Translation:Humans
  139. Quintana FJ, Cohen IR. The HSP60 immune system network. Trends Immunol. 2011 Feb; 32(2):89-95. PMID: 21145789.
    Citations: 54     Fields:    Translation:HumansAnimals
  140. Quintana FJ, Murugaiyan G, Farez MF, Mitsdoerffer M, Tukpah AM, Burns EJ, Weiner HL. An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2010 Nov 30; 107(48):20768-73. PMID: 21068375.
    Citations: 176     Fields:    Translation:AnimalsCells
  141. Gandhi R, Kumar D, Burns EJ, Nadeau M, Dake B, Laroni A, Kozoriz D, Weiner HL, Quintana FJ. Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells. Nat Immunol. 2010 Sep; 11(9):846-53. PMID: 20676092.
    Citations: 183     Fields:    Translation:HumansAnimalsCells
  142. Apetoh L, Quintana FJ, Pot C, Joller N, Xiao S, Kumar D, Burns EJ, Sherr DH, Weiner HL, Kuchroo VK. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat Immunol. 2010 Sep; 11(9):854-61. PMID: 20676095.
    Citations: 310     Fields:    Translation:AnimalsCells
  143. Dardalhon V, Anderson AC, Karman J, Apetoh L, Chandwaskar R, Lee DH, Cornejo M, Nishi N, Yamauchi A, Quintana FJ, Sobel RA, Hirashima M, Kuchroo VK. Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells. J Immunol. 2010 Aug 01; 185(3):1383-92. PMID: 20574007.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  144. Rodriguez-Manzanet R, Sanjuan MA, Wu HY, Quintana FJ, Xiao S, Anderson AC, Weiner HL, Green DR, Kuchroo VK. T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8706-11. PMID: 20368430.
    Citations: 87     Fields:    Translation:AnimalsCells
  145. Gandhi R, Farez MF, Wang Y, Kozoriz D, Quintana FJ, Weiner HL. Cutting edge: human latency-associated peptide+ T cells: a novel regulatory T cell subset. J Immunol. 2010 May 01; 184(9):4620-4. PMID: 20368276.
    Citations: 52     Fields:    Translation:HumansCells
  146. Quintana FJ, Iglesias AH, Farez MF, Caccamo M, Burns EJ, Kassam N, Oukka M, Weiner HL. Adaptive autoimmunity and Foxp3-based immunoregulation in zebrafish. PLoS One. 2010 Mar 05; 5(3):e9478. PMID: 20221429.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  147. Ilan Y, Zigmond E, Lalazar G, Dembinsky A, Ben Ya'acov A, Hemed N, Kasis I, Axelrod E, Zolotarov L, Klein A, El Haj M, Gandhi R, Baecher-Allan C, Wu H, Murugaiyan G, Kivisakk P, Farez MF, Quintana FJ, Khoury SJ, Weiner HL. Oral administration of OKT3 monoclonal antibody to human subjects induces a dose-dependent immunologic effect in T cells and dendritic cells. J Clin Immunol. 2010 Jan; 30(1):167-77. PMID: 19756989.
    Citations: 28     Fields:    Translation:HumansCellsCTClinical Trials
  148. Herrera JL, Gonzalez-Rey E, Fernandez-Montesinos R, Quintana FJ, Najmanovich R, Pozo D. Toll-like receptor stimulation differentially regulates vasoactive intestinal peptide type 2 receptor in macrophages. J Cell Mol Med. 2009 Sep; 13(9B):3209-17. PMID: 20196778.
    Citations: 11     Fields:    Translation:AnimalsCells
  149. Farez MF, Quintana FJ, Gandhi R, Izquierdo G, Lucas M, Weiner HL. Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE. Nat Immunol. 2009 Sep; 10(9):958-64. PMID: 19684606.
    Citations: 84     Fields:    Translation:HumansAnimals
  150. Madi A, Hecht I, Bransburg-Zabary S, Merbl Y, Pick A, Zucker-Toledano M, Quintana FJ, Tauber AI, Cohen IR, Ben-Jacob E. Organization of the autoantibody repertoire in healthy newborns and adults revealed by system level informatics of antigen microarray data. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14484-9. PMID: 19667184.
    Citations: 32     Fields:    Translation:Humans
  151. Merbl Y, Itzchak R, Vider-Shalit T, Louzoun Y, Quintana FJ, Vadai E, Eisenbach L, Cohen IR. A systems immunology approach to the host-tumor interaction: large-scale patterns of natural autoantibodies distinguish healthy and tumor-bearing mice. PLoS One. 2009 Jun 25; 4(6):e6053. PMID: 19557135.
    Citations: 11     Fields:    Translation:AnimalsCells
  152. Kivisäkk P, Healy BC, Viglietta V, Quintana FJ, Hootstein MA, Weiner HL, Khoury SJ. Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells. Neurology. 2009 Jun 02; 72(22):1922-30. PMID: 19487650.
    Citations: 57     Fields:    Translation:HumansCells
  153. Quintana FJ, Weiner HL. Environmental control of Th17 differentiation. Eur J Immunol. 2009 Mar; 39(3):655-7. PMID: 19283716.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  154. Quintana FJ, Mimran A, Carmi P, Mor F, Cohen IR. HSP60 as a target of anti-ergotypic regulatory T cells. PLoS One. 2008; 3(12):e4026. PMID: 19107191.
    Citations: 9     Fields:    Translation:AnimalsCells
  155. Quintana FJ, Farez MF, Viglietta V, Iglesias AH, Merbl Y, Izquierdo G, Lucas M, Basso AS, Khoury SJ, Lucchinetti CF, Cohen IR, Weiner HL. Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis. Proc Natl Acad Sci U S A. 2008 Dec 02; 105(48):18889-94. PMID: 19028871.
    Citations: 96     Fields:    Translation:HumansAnimals
  156. Wu HY, Quintana FJ, Weiner HL. Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells. J Immunol. 2008 Nov 01; 181(9):6038-50. PMID: 18941193.
    Citations: 71     Fields:    Translation:AnimalsCells
  157. Quintana FJ, Solomon A, Cohen IR, Nussbaum G. Induction of IgG3 to LPS via Toll-like receptor 4 co-stimulation. PLoS One. 2008; 3(10):e3509. PMID: 18946502.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  158. Quintana FJ, Farez MF, Weiner HL. Systems biology approaches for the study of multiple sclerosis. J Cell Mol Med. 2008 Aug; 12(4):1087-93. PMID: 18505469.
    Citations: 10     Fields:    Translation:HumansAnimals
  159. Basso AS, Frenkel D, Quintana FJ, Costa-Pinto FA, Petrovic-Stojkovic S, Puckett L, Monsonego A, Bar-Shir A, Engel Y, Gozin M, Weiner HL. Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis. J Clin Invest. 2008 Apr; 118(4):1532-43. PMID: 18340379.
    Citations: 73     Fields:    Translation:AnimalsCells
  160. Quintana FJ, Cohen IR. Regulatory T cells and immune computation. Eur J Immunol. 2008 Apr; 38(4):903-7. PMID: 18395856.
    Citations: 3     Fields:    Translation:Cells
  161. Quintana FJ, Basso AS, Iglesias AH, Korn T, Farez MF, Bettelli E, Caccamo M, Oukka M, Weiner HL. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature. 2008 May 01; 453(7191):65-71. PMID: 18362915.
    Citations: 672     Fields:    Translation:HumansAnimalsCells
  162. Quintana FJ, Cohen IR. HSP60 speaks to the immune system in many voices. Novartis Found Symp. 2008; 291:101-11; discussion 111-4, 137-40. PMID: 18575269.
    Citations: 7     Fields:    Translation:Humans
  163. Baharav E, Mor F, Halpern M, Quintana F, Weinberger A. Tropomyosin-induced arthritis in rats. Clin Exp Rheumatol. 2007 Jul-Aug; 25(4 Suppl 45):S86-92. PMID: 17949558.
    Citations: 1     Fields:    Translation:Animals
  164. Shternhall-Ron K, Quintana FJ, Perl S, Meivar-Levy I, Barshack I, Cohen IR, Ferber S. Ectopic PDX-1 expression in liver ameliorates type 1 diabetes. J Autoimmun. 2007 Mar-May; 28(2-3):134-42. PMID: 17383157.
    Citations: 21     Fields:    Translation:AnimalsCells
  165. Merbl Y, Zucker-Toledano M, Quintana FJ, Cohen IR. Newborn humans manifest autoantibodies to defined self molecules detected by antigen microarray informatics. J Clin Invest. 2007 Mar; 117(3):712-8. PMID: 17332892.
    Citations: 82     Fields:    Translation:Humans
  166. Quintana FJ, Gerber D, Bloch I, Cohen IR, Shai Y. A structurally altered D,L-amino acid TCRalpha transmembrane peptide interacts with the TCRalpha and inhibits T-cell activation in vitro and in an animal model. Biochemistry. 2007 Mar 06; 46(9):2317-25. PMID: 17288453.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  167. Bloch I, Quintana FJ, Gerber D, Cohen T, Cohen IR, Shai Y. T-cell inactivation and immunosuppressive activity induced by HIV gp41 via novel interacting motif. FASEB J. 2007 Feb; 21(2):393-401. PMID: 17185749.
    Citations: 17     Fields:    Translation:AnimalsCells
  168. Quintana FJ, Cohen IR. Anti-ergotypic immunoregulation. Scand J Immunol. 2006 Sep; 64(3):205-10. PMID: 16918688.
    Citations: 7     Fields:    Translation:HumansAnimalsCells