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Eliyahu Khankin, M.D.

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Biography
2003
Doctor of Medicine - Cum Laude
2008
Fellow of American Society of Nephrology (FASN)
2014
Physician Scientist Award
2018
Editorial Board - Hypertension
2018
Editorial Board - Journal of Nephrology and Urology
2019
Fellow (overseas) Royal Society of Medicine (UK) (FRSM)
2019
Fellow of American Society of Transplantation (FAST)

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL133399 (BERG, ANDERS HAYDEN) Apr 1, 2018 - Jan 31, 2022
    NIH/NHLBI
    Protein carbamylation and uremic cardiomyopathy in chronic kidney disease
    Role: Co-Investigator
  2. R03DK115793 (KHANKIN, ELIYAHU) Feb 1, 2018 - Jan 31, 2020
    NIH/NIDDK
    Mechanisms of Dyslipidemia following Preeclampsia
    Role: Principal Investigator
  3. R03DK115793 (KHANKIN, ELIYAHU) Feb 1, 2018 - Jan 31, 2020
    NIH/NIDDK
    Mechanisms of Dyslipidemia following Preeclampsia
    Role: Principal Investigator
  4. R01HL134371 (OSOL, GEORGE J) Jul 15, 2016 - Jun 30, 2020
    NIH
    Shear Stress-Induced Maternal Uterine Vascular Remodeling During Pregnancy
    Role: Co-Investigator
  5. K08DK101560 (KHANKIN, ELIYAHU) Jul 1, 2014 - Jun 30, 2019
    NIH/NIDDK
    Preeclampsia and renal complications: late effects on kidney and vasculature
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yonekura Collier A, Zsengeller Z, Pernicone E, Salahuddin S, Khankin EV, Karumanchi SA. Placental sFLT1 is associated with complement activation and syncytiotrophoblast damage in preeclampsia. Hypertension in Pregnancy. 2019; DOI: 10.1080/10641955.2019.16.
  2. Yang D, Thamcharoen N, Marcus C, Varkaris A, Aird W, Khankin EV, Cardarelli F. Unusual Presentation of Hemophagocytic Lymphohistiocytosis in a Kidney Transplant Patient. Case Rep Transplant. 2019; 2019:3682378. PMID: 30984439.
    Citations:    
  3. Leeaphorn N, Garg N, Thamcharoen N, Khankin EV, Cardarelli F, Pavlakis M. Cytomegalovirus mismatch still negatively affects patient and graft survival in the era of routine prophylactic and preemptive therapy: A paired kidney analysis. Am J Transplant. 2019 Feb; 19(2):573-584. PMID: 30431703.
    Citations:    Fields:    
  4. Garg N, Zhang Y, Nicholson-Weller A, Khankin EV, Borsa NG, Meyer NC, McDermott S, Stillman IE, Rennke HG, Smith RJ, Pavlakis M. C3 glomerulonephritis secondary to mutations in factors H and I: rapid recurrence in deceased donor kidney transplant effectively treated with eculizumab. Nephrol Dial Transplant. 2018 Dec 01; 33(12):2260-2265. PMID: 29370420.
    Citations: 1     Fields:    
  5. Uffing A, Pérez-Sáez MJ, La Manna G, Comai G, Fischman C, Farouk S, Manfro RC, Bauer AC, Lichtenfels B, Mansur JB, Tedesco-Silva H, Kirsztajn GM, Manonelles A, Bestard O, Riella MC, Hokazono SR, Arias-Cabrales C, David-Neto E, Ventura CG, Akalin E, Mohammed O, Khankin EV, Safa K, Malvezzi P, O'Shaughnessy MM, Cheng XS, Cravedi P, Riella LV. A large, international study on post-transplant glomerular diseases: the TANGO project. BMC Nephrol. 2018 09 12; 19(1):229. PMID: 30208881.
    Citations:    Fields:    
  6. Leeaphorn N, Pena JRA, Thamcharoen N, Khankin EV, Pavlakis M, Cardarelli F. HLA-DQ Mismatching and Kidney Transplant Outcomes. Clin J Am Soc Nephrol. 2018 May 07; 13(5):763-771. PMID: 29685925.
    Citations: 1     Fields:    
  7. Drury ER, Zsengeller ZK, Stillman IE, Khankin EV, Pavlakis M, Parikh SM. Renal PGC1a May Be Associated with Recovery after Delayed Graft Function. Nephron. 2018; 138(4):303-309. PMID: 29268263.
    Citations:    Fields:    
  8. Leeaphorn N, Garg N, Khankin EV, Cardarelli F, Pavlakis M. Recurrence of IgA nephropathy after kidney transplantation in steroid continuation versus early steroid-withdrawal regimens: a retrospective analysis of the UNOS/OPTN database. Transpl Int. 2018 02; 31(2):175-186. PMID: 28926143.
    Citations: 1     Fields:    Translation:Humans
  9. Phipps EA, Khankin EV. Extracellular Vesicles in Preeclampsia: Evolving Contributors to Proteinuria. J Am Soc Nephrol. 2017 11; 28(11):3135-3137. PMID: 28928135.
    Citations:    Fields:    
  10. Burke SD, Zsengellér ZK, Khankin EV, Lo AS, Rajakumar A, DuPont JJ, McCurley A, Moss ME, Zhang D, Clark CD, Wang A, Seely EW, Kang PM, Stillman IE, Jaffe IZ, Karumanchi SA. Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia. J Clin Invest. 2016 07 01; 126(7):2561-74. PMID: 27270170.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  11. Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W, Clish CB, Stillman IE, Karumanchi SA, Rhee EP, Parikh SM. PGC1a drives NAD biosynthesis linking oxidative metabolism to renal protection. Nature. 2016 Mar 24; 531(7595):528-32. PMID: 26982719.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  12. Khankin EV, Arany Z. Echoes of Preeclampsia: Can Echocardiography Help Predict Recurrence? Hypertension. 2016 Apr; 67(4):690-2. PMID: 26902489.
    Citations:    Fields:    Translation:Humans
  13. Penning M, Chua JS, van Kooten C, Zandbergen M, Buurma A, Schutte J, Bruijn JA, Khankin EV, Bloemenkamp K, Karumanchi SA, Baelde H. Classical Complement Pathway Activation in the Kidneys of Women With Preeclampsia. Hypertension. 2015 Jul; 66(1):117-25. PMID: 25941343.
    Citations: 8     Fields:    Translation:HumansAnimals
  14. Pruthi D, Khankin EV, Blanton RM, Aronovitz M, Burke SD, McCurley A, Karumanchi SA, Jaffe IZ. Exposure to experimental preeclampsia in mice enhances the vascular response to future injury. Hypertension. 2015 Apr; 65(4):863-70. PMID: 25712723.
    Citations: 12     Fields:    Translation:Animals
  15. Gennari-Moser C, Khankin EV, Escher G, Burkhard F, Frey BM, Karumanchi SA, Frey FJ, Mohaupt MG. Response to "Are aldosterone levels inappropriately low in preeclampsia"? Hypertension. 2013 Nov; 62(5):e40. PMID: 24288784.
    Citations:    Fields:    Translation:HumansAnimals
  16. Gennari-Moser C, Khankin EV, Escher G, Burkhard F, Frey BM, Karumanchi SA, Frey FJ, Mohaupt MG. Vascular endothelial growth factor-A and aldosterone: relevance to normal pregnancy and preeclampsia. Hypertension. 2013 May; 61(5):1111-7. PMID: 23460276.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  17. David S, Mukherjee A, Ghosh CC, Yano M, Khankin EV, Wenger JB, Karumanchi SA, Shapiro NI, Parikh SM. Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*. Crit Care Med. 2012 Nov; 40(11):3034-41. PMID: 22890252.
    Citations: 51     Fields:    Translation:HumansAnimals
  18. Gennari-Moser C, Khankin EV, Escher G, Burkhard F, Frey BM, Karumanchi AS, Frey FJ, Mohaupt MG. OS067. VEGF, a novel stimulator of aldosterone production. Pregnancy Hypertens. 2012 Jul; 2(3):213. PMID: 26105281.
    Citations:    Fields:    
  19. Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, del Monte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z. Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature. 2012 May 09; 485(7398):333-8. PMID: 22596155.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  20. Khankin EV, Mandala M, Colton I, Karumanchi SA, Osol G. Hemodynamic, vascular, and reproductive impact of FMS-like tyrosine kinase 1 (FLT1) blockade on the uteroplacental circulation during normal mouse pregnancy. Biol Reprod. 2012 Feb; 86(2):57. PMID: 22075472.
    Citations:    Fields:    Translation:Animals
  21. Khankin EV, Hacker MR, Zelop CM, Karumanchi SA, Rana S. Intravital high-frequency ultrasonography to evaluate cardiovascular and uteroplacental blood flow in mouse pregnancy. Pregnancy Hypertens. 2012 Apr; 2(2):84-92. PMID: 22544045.
    Citations: 3     Fields:    
  22. Burke SD, Barrette VF, David S, Khankin EV, Adams MA, Croy BA. Circulatory and renal consequences of pregnancy in diabetic NOD mice. Placenta. 2011 Dec; 32(12):949-55. PMID: 22014504.
    Citations: 2     Fields:    Translation:Animals
  23. Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman IE, Arany Z, Parikh SM. PGC-1a promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest. 2011 Oct; 121(10):4003-14. PMID: 21881206.
    Citations: 90     Fields:    Translation:AnimalsCells
  24. David S, Ghosh CC, Kümpers P, Shushakova N, Van Slyke P, Khankin EV, Karumanchi SA, Dumont D, Parikh SM. Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality. Am J Physiol Lung Cell Mol Physiol. 2011 Jun; 300(6):L851-62. PMID: 21421750.
    Citations: 34     Fields:    Translation:HumansAnimals
  25. Gennari-Moser C, Khankin EV, Schüller S, Escher G, Frey BM, Portmann CB, Baumann MU, Lehmann AD, Surbek D, Karumanchi SA, Frey FJ, Mohaupt MG. Regulation of placental growth by aldosterone and cortisol. Endocrinology. 2011 Jan; 152(1):263-71. PMID: 21068161.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  26. Weiner D, Khankin EV, Levy Y, Aizenbud D, Reznick AZ. Effects of cigarette smoke on salivary protein tyrosine nitration. Eur J Med Res. 2010 Nov 04; 15 Suppl 2:211-6. PMID: 21147654.
    Citations: 1     Fields:    Translation:HumansAnimals
  27. Robinson ES, Khankin EV, Karumanchi SA, Humphreys BD. Hypertension induced by vascular endothelial growth factor signaling pathway inhibition: mechanisms and potential use as a biomarker. Semin Nephrol. 2010 Nov; 30(6):591-601. PMID: 21146124.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  28. Robinson ES, Khankin EV, Choueiri TK, Dhawan MS, Rogers MJ, Karumanchi SA, Humphreys BD. Suppression of the nitric oxide pathway in metastatic renal cell carcinoma patients receiving vascular endothelial growth factor-signaling inhibitors. Hypertension. 2010 Dec; 56(6):1131-6. PMID: 20956731.
    Citations: 26     Fields:    Translation:Humans
  29. Shapiro NI, Khankin EV, Van Meurs M, Shih SC, Lu S, Yano M, Castro PR, Maratos-Flier E, Parikh SM, Karumanchi SA, Yano K. Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol. 2010 Jul 01; 185(1):517-24. PMID: 20519646.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  30. Khankin EV, Royle C, Karumanchi SA. Placental vasculature in health and disease. Semin Thromb Hemost. 2010 Apr; 36(3):309-20. PMID: 20490981.
    Citations: 12     Fields:    Translation:Humans
  31. Steinberg G, Lee C, Rauh-Hain JA, Ecker J, Khankin EV, Hsu CD, Cohen B, Rana S, Karumanchi SA, Thadhani R, Hacker MR, Lim KH. Early-pregnancy soluble Fas levels in idiopathic small-for-gestational-age pregnancies. Am J Obstet Gynecol. 2010 Mar; 202(3):299.e1-7. PMID: 20207247.
    Citations: 3     Fields:    Translation:Humans
  32. Khankin EV, Mutter WP, Tamez H, Yuan HT, Karumanchi SA, Thadhani R. Soluble erythropoietin receptor contributes to erythropoietin resistance in end-stage renal disease. PLoS One. 2010 Feb 16; 5(2):e9246. PMID: 20169072.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  33. Thadhani R, Powe CE, Tjoa ML, Khankin E, Ye J, Ecker J, Schneyer A, Karumanchi SA. First-trimester follistatin-like-3 levels in pregnancies complicated by subsequent gestational diabetes mellitus. Diabetes Care. 2010 Mar; 33(3):664-9. PMID: 20007937.
    Citations: 12     Fields:    Translation:Humans
  34. Weiner D, Khankin EV, Levy Y, Reznick AZ. Effects of cigarette smoke borne reactive nitrogen species on salivary alpha-amylase activity and protein modifications. J Physiol Pharmacol. 2009 Nov; 60 Suppl 5:127-32. PMID: 20134053.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  35. Yuan HT, Khankin EV, Karumanchi SA, Parikh SM. Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. Mol Cell Biol. 2009 Apr; 29(8):2011-22. PMID: 19223473.
    Citations: 101     Fields:    Translation:HumansCells
  36. Steinberg G, Rauh-Hain JA, Ecker J, Lee C, Khankin EV, Cohen B,Rana S, Karumanchi SA, Thadhani RI, Lim KH. Second trimester serum soluble Fas (sFas) levels are lower in SGA pregnancies. 2009.
  37. Weiner D, Levy Y, Khankin EV, Reznick AZ. Inhibition of salivary amylase activity by cigarette smoke aldehydes. Journal of Physiology and Pharmacology. 2009; 59(S), Accepted for Publicatio.
  38. Steinberg G, Khankin EV, Karumanchi SA. Angiogenic Factors and Preeclampsia. Seminars in Thrombosis and Hemostasis. 2009; Accepted for Publication.
  39. Steinberg G, Khankin EV, Karumanchi SA. Angiogenic factors and preeclampsia. Thromb Res. 2009; 123 Suppl 2:S93-9. PMID: 19217486.
    Citations: 13     Fields:    Translation:Humans
  40. Weiner D, Levy Y, Khankin EV, Reznick AZ. Inhibition of salivary amylase activity by cigarette smoke aldehydes. J Physiol Pharmacol. 2008 Dec; 59 Suppl 6:727-37. PMID: 19218700.
    Citations: 1     Fields:    Translation:HumansAnimals
  41. Walter P. Mutter, Hector Tamez, Eliyahu V. Khankin, S. Ananth Karumanchi. Soluble Erythropoietin receptor levels predict subsequent Erythropoietin dose in hemodialysis patients. 2008.
  42. Eliyahu V. Khankin, Samir M. Parikh, Isaac E. Stillman, Michael J Somers, S. Ananth Karumanchi. Animal model of Minimal Change Disease. 2008.
  43. Hai-Tao Yuan, Eliyahu V. Khankin, S. Ananth Karumanchi. Protective effects of Tie2-agonistic antibodies in Folic Acid induced nephropathy model. 2008.
  44. Nakhoul F, Khankin E, Yaccob A, Kawachi H, Karram T, Awaad H, Nakhoul N, Hoffman A, Abassi Z. Eplerenone potentiates the antiproteinuric effects of enalapril in experimental nephrotic syndrome. Am J Physiol Renal Physiol. 2008 Mar; 294(3):F628-37. PMID: 18094029.
    Citations: 5     Fields:    Translation:Animals
  45. Blum S, Nakhoul F, Khankin E, Abassi Z. Renal slit diaphragm--the open zipper and the failing heart. Isr Med Assoc J. 2007 Feb; 9(2):107-11. PMID: 17348483.
    Citations: 2     Fields:    Translation:HumansCells
  46. Rana S, Rauh-Hain A, Ecker J, Shivalingappa V, Khankin E, Karumanchi A, Thadhani R. First trimester angiogenic proteins and the risk of intrauterine fetal demise. 2007.
  47. Abassi Z, Nakhoul F, Khankin E, Reisner SA, Yigla M. Pulmonary hypertension in chronic dialysis patients with arteriovenous fistula: pathogenesis and therapeutic prospective. Curr Opin Nephrol Hypertens. 2006 Jul; 15(4):353-60. PMID: 16775448.
    Citations: 13     Fields:    Translation:Humans
  48. Nakhoul F, Khankin E, Ramadan R, Karam T, Awad H, Yaccob A, Abassi Z. Anti-proteinuric effects of Eplerenone, a Selective Aldosterone Blocker in experimental Nephrotic Syndrome: Correlation with Nephrin and Podocin abundance. 2006.
  49. Nakhoul F, Ramadan R, Khankin E, Yaccob A, Kositch Z, Lewin M, Assady S, Abassi Z. Glomerular abundance of nephrin and podocin in experimental nephrotic syndrome: different effects of antiproteinuric therapies. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F880-90. PMID: 15942045.
    Citations: 9     Fields:    Translation:Animals
  50. Nakhoul F, Ramadan R, Assady S, Khankin E, Lewin M, Abassi Z. Glomerular abundance of nephrin and podocin in experimental nephrotic syndrome: different effects of anti-proteinuric therapies. 2005.
  51. Nakhoul F, Lotan R, Aronson D, Roy A, Khankin E, Miller B, Levy A. Kidney and eye disease in diabetic mice genetically modified at the haptoglobin locus. 2005.
  52. Khankin E, Knechtel L, Tobe S. Current Trends in Continuous Renal Replacement Therapy – Ontario Region. 2005.
  53. Nakhoul F, Abassi Z, Plawner M, Khankin E, Ramadan R, Lanir N, Brenner B, Green J. Comparative study of response to treatment with supraphysiologic doses of B-vitamins in hyperhomocysteinemic hemodialysis patients. Isr Med Assoc J. 2004 Apr; 6(4):213-7. PMID: 15115259.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  54. Gelman R, Khankin E, Ben-Itzhak A, Finkelshtein R, Nakhoul F. Herpes simplex viral infection presenting as fever of unknown origin and esophagitis in a renal transplant patient. Isr Med Assoc J. 2002 Nov; 4(11 Suppl):970-1. PMID: 12455194.
    Citations:    Fields:    Translation:Humans
  55. Armaly Z, Khankin E, Ramadan R, Ben-Itzhak O, Guralnik L, Green J, Nakhoul F. Two cases of renal mucormycosis in renal transplanted patients. Clin Nephrol. 2002 Sep; 58(3):247-9. PMID: 12356197.
    Citations: 3     Fields:    Translation:Humans
  56. Blazer S, Khankin E, Segev Y, Ofir R, Yalon-Hacohen M, Kra-Oz Z, Gottfried Y, Larisch S, Skorecki KL. High glucose-induced replicative senescence: point of no return and effect of telomerase. Biochem Biophys Res Commun. 2002 Aug 09; 296(1):93-101. PMID: 12147232.
    Citations: 21     Fields:    Translation:HumansCells
  57. Nakhoul F, Gelman R, Green J, Khankin E, Baruch Y. Lamivudine therapy for severe acute hepatitis B virus infection after renal transplantation: case report and literature review. Transplant Proc. 2001 Sep; 33(6):2948-9. PMID: 11543804.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.