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Eliyahu Khankin, M.D.


Doctor of Medicine - Cum Laude
Fellow of American Society of Nephrology (FASN)
Physician Scientist Award
Editorial Board - Hypertension
Editorial Board - Journal of Nephrology and Urology
Fellow (overseas) Royal Society of Medicine (UK) (FRSM)
Fellow of American Society of Transplantation (FAST)
Editorial Board - Frontiers in Med

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL133399 (BERG, ANDERS HAYDEN) Apr 1, 2018 - Jan 31, 2022
    Protein carbamylation and uremic cardiomyopathy in chronic kidney disease
    Role: Co-Investigator
  2. R03DK115793 (KHANKIN, ELIYAHU) Feb 1, 2018 - Jan 31, 2020
    Mechanisms of Dyslipidemia following Preeclampsia
    Role: Principal Investigator
  3. R03DK115793 (KHANKIN, ELIYAHU) Feb 1, 2018 - Nov 4, 2018
    Mechanisms of Dyslipidemia following Preeclampsia
    Role: Principal Investigator
  4. R01HL134371 (OSOL, GEORGE J) Jul 15, 2016 - Jun 30, 2020
    Shear Stress-Induced Maternal Uterine Vascular Remodeling During Pregnancy
    Role: Co-Investigator
  5. K08DK101560 (KHANKIN, ELIYAHU) Jul 1, 2014 - Sep 30, 2018
    Preeclampsia and renal complications: late effects on kidney and vasculature
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Khankin EV, Ko NL, Mandalà M, Karumanchi SA, Osol G. Normalization of wall shear stress as a physiological mechanism for regulating maternal uterine artery expansive remodeling during pregnancy. FASEB Bioadv. 2021 Sep; 3(9):702-708. PMID: 34485839.
  2. Roth Flach RJ, Khankin EV. Peripartum Cardiomyopathy: Is It All in the Timing? Hypertension. 2020 01; 75(1):33-34. PMID: 31707839.
    Citations: 1     Fields:    Translation:Humans
  3. Yonekura Collier AR, Zsengeller Z, Pernicone E, Salahuddin S, Khankin EV, Karumanchi SA. Placental sFLT1 is associated with complement activation and syncytiotrophoblast damage in preeclampsia. Hypertens Pregnancy. 2019 Aug; 38(3):193-199. PMID: 31291799; PMCID: PMC6707710.
    Citations: 15     Fields:    Translation:HumansCells
  4. Yang D, Thamcharoen N, Marcus C, Varkaris A, Aird W, Khankin EV, Cardarelli F. Unusual Presentation of Hemophagocytic Lymphohistiocytosis in a Kidney Transplant Patient. Case Rep Transplant. 2019; 2019:3682378. PMID: 30984439; PMCID: PMC6431471.
    Citations: 3     
  5. Leeaphorn N, Garg N, Thamcharoen N, Khankin EV, Cardarelli F, Pavlakis M. Cytomegalovirus mismatch still negatively affects patient and graft survival in the era of routine prophylactic and preemptive therapy: A paired kidney analysis. Am J Transplant. 2019 02; 19(2):573-584. PMID: 30431703.
    Citations: 18     Fields:    Translation:HumansCells
  6. Garg N, Zhang Y, Nicholson-Weller A, Khankin EV, Borsa NG, Meyer NC, McDermott S, Stillman IE, Rennke HG, Smith RJ, Pavlakis M. C3 glomerulonephritis secondary to mutations in factors H and I: rapid recurrence in deceased donor kidney transplant effectively treated with eculizumab. Nephrol Dial Transplant. 2018 12 01; 33(12):2260-2265. PMID: 29370420; PMCID: PMC6275145.
    Citations: 9     Fields:    Translation:Humans
  7. Uffing A, Pérez-Sáez MJ, La Manna G, Comai G, Fischman C, Farouk S, Manfro RC, Bauer AC, Lichtenfels B, Mansur JB, Tedesco-Silva H, Kirsztajn GM, Manonelles A, Bestard O, Riella MC, Hokazono SR, Arias-Cabrales C, David-Neto E, Ventura CG, Akalin E, Mohammed O, Khankin EV, Safa K, Malvezzi P, O'Shaughnessy MM, Cheng XS, Cravedi P, Riella LV. A large, international study on post-transplant glomerular diseases: the TANGO project. BMC Nephrol. 2018 09 12; 19(1):229. PMID: 30208881.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  8. Leeaphorn N, Pena JRA, Thamcharoen N, Khankin EV, Pavlakis M, Cardarelli F. HLA-DQ Mismatching and Kidney Transplant Outcomes. Clin J Am Soc Nephrol. 2018 05 07; 13(5):763-771. PMID: 29685925.
    Citations: 9     Fields:    Translation:Humans
  9. Drury ER, Zsengeller ZK, Stillman IE, Khankin EV, Pavlakis M, Parikh SM. Renal PGC1a May Be Associated with Recovery after Delayed Graft Function. Nephron. 2018; 138(4):303-309. PMID: 29268263.
    Citations: 7     Fields:    Translation:HumansCells
  10. Leeaphorn N, Garg N, Khankin EV, Cardarelli F, Pavlakis M. Recurrence of IgA nephropathy after kidney transplantation in steroid continuation versus early steroid-withdrawal regimens: a retrospective analysis of the UNOS/OPTN database. Transpl Int. 2018 02; 31(2):175-186. PMID: 28926143; PMCID: PMC5762402.
    Citations: 13     Fields:    Translation:Humans
  11. Phipps EA, Khankin EV. Extracellular Vesicles in Preeclampsia: Evolving Contributors to Proteinuria. J Am Soc Nephrol. 2017 11; 28(11):3135-3137. PMID: 28928135; PMCID: PMC5661298.
    Citations:    Fields:    Translation:HumansCells
  12. Burke SD, Zsengellér ZK, Khankin EV, Lo AS, Rajakumar A, DuPont JJ, McCurley A, Moss ME, Zhang D, Clark CD, Wang A, Seely EW, Kang PM, Stillman IE, Jaffe IZ, Karumanchi SA. Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia. J Clin Invest. 2016 07 01; 126(7):2561-74. PMID: 27270170; PMCID: PMC4922717.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  13. Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W, Clish CB, Stillman IE, Karumanchi SA, Rhee EP, Parikh SM. PGC1a drives NAD biosynthesis linking oxidative metabolism to renal protection. Nature. 2016 Mar 24; 531(7595):528-32. PMID: 26982719.
    Citations: 193     Fields:    Translation:HumansAnimalsCells
  14. Khankin EV, Arany Z. Echoes of Preeclampsia: Can Echocardiography Help Predict Recurrence? Hypertension. 2016 Apr; 67(4):690-2. PMID: 26902489.
    Citations:    Fields:    Translation:Humans
  15. Penning M, Chua JS, van Kooten C, Zandbergen M, Buurma A, Schutte J, Bruijn JA, Khankin EV, Bloemenkamp K, Karumanchi SA, Baelde H. Classical Complement Pathway Activation in the Kidneys of Women With Preeclampsia. Hypertension. 2015 Jul; 66(1):117-25. PMID: 25941343.
    Citations: 25     Fields:    Translation:HumansAnimals
  16. Pruthi D, Khankin EV, Blanton RM, Aronovitz M, Burke SD, McCurley A, Karumanchi SA, Jaffe IZ. Exposure to experimental preeclampsia in mice enhances the vascular response to future injury. Hypertension. 2015 Apr; 65(4):863-70. PMID: 25712723; PMCID: PMC4359068.
    Citations: 25     Fields:    Translation:Animals
  17. Gennari-Moser C, Khankin EV, Escher G, Burkhard F, Frey BM, Karumanchi SA, Frey FJ, Mohaupt MG. Response to "Are aldosterone levels inappropriately low in preeclampsia"? Hypertension. 2013 Nov; 62(5):e40. PMID: 24288784.
    Citations:    Fields:    Translation:HumansAnimals
  18. Gennari-Moser C, Khankin EV, Escher G, Burkhard F, Frey BM, Karumanchi SA, Frey FJ, Mohaupt MG. Vascular endothelial growth factor-A and aldosterone: relevance to normal pregnancy and preeclampsia. Hypertension. 2013 May; 61(5):1111-7. PMID: 23460276.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  19. David S, Mukherjee A, Ghosh CC, Yano M, Khankin EV, Wenger JB, Karumanchi SA, Shapiro NI, Parikh SM. Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*. Crit Care Med. 2012 Nov; 40(11):3034-41. PMID: 22890252; PMCID: PMC3705559.
    Citations: 80     Fields:    Translation:HumansAnimals
  20. Gennari-Moser C, Khankin EV, Escher G, Burkhard F, Frey BM, Karumanchi AS, Frey FJ, Mohaupt MG. OS067. VEGF, a novel stimulator of aldosterone production. Pregnancy Hypertens. 2012 Jul; 2(3):213. PMID: 26105281.
    Citations:    Fields:    
  21. Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, del Monte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z. Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature. 2012 May 09; 485(7398):333-8. PMID: 22596155; PMCID: PMC3356917.
    Citations: 175     Fields:    Translation:HumansAnimalsCells
  22. Khankin EV, Mandala M, Colton I, Karumanchi SA, Osol G. Hemodynamic, vascular, and reproductive impact of FMS-like tyrosine kinase 1 (FLT1) blockade on the uteroplacental circulation during normal mouse pregnancy. Biol Reprod. 2012 Feb; 86(2):57. PMID: 22075472.
    Citations: 7     Fields:    Translation:Animals
  23. Khankin EV, Hacker MR, Zelop CM, Karumanchi SA, Rana S. Intravital high-frequency ultrasonography to evaluate cardiovascular and uteroplacental blood flow in mouse pregnancy. Pregnancy Hypertens. 2012 Apr; 2(2):84-92. PMID: 22544045; PMCID: PMC3337859.
    Citations: 5     Fields:    
  24. Burke SD, Barrette VF, David S, Khankin EV, Adams MA, Croy BA. Circulatory and renal consequences of pregnancy in diabetic NOD mice. Placenta. 2011 Dec; 32(12):949-55. PMID: 22014504.
    Citations: 4     Fields:    Translation:Animals
  25. Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman IE, Arany Z, Parikh SM. PGC-1a promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest. 2011 Oct; 121(10):4003-14. PMID: 21881206; PMCID: PMC3195479.
    Citations: 224     Fields:    Translation:AnimalsCells
  26. David S, Ghosh CC, Kümpers P, Shushakova N, Van Slyke P, Khankin EV, Karumanchi SA, Dumont D, Parikh SM. Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality. Am J Physiol Lung Cell Mol Physiol. 2011 Jun; 300(6):L851-62. PMID: 21421750.
    Citations: 52     Fields:    Translation:HumansAnimals
  27. Gennari-Moser C, Khankin EV, Schüller S, Escher G, Frey BM, Portmann CB, Baumann MU, Lehmann AD, Surbek D, Karumanchi SA, Frey FJ, Mohaupt MG. Regulation of placental growth by aldosterone and cortisol. Endocrinology. 2011 Jan; 152(1):263-71. PMID: 21068161.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  28. Weiner D, Khankin EV, Levy Y, Aizenbud D, Reznick AZ. Effects of cigarette smoke on salivary protein tyrosine nitration. Eur J Med Res. 2010 Nov 04; 15 Suppl 2:211-6. PMID: 21147654.
    Citations: 2     Fields:    Translation:HumansAnimals
  29. Robinson ES, Khankin EV, Karumanchi SA, Humphreys BD. Hypertension induced by vascular endothelial growth factor signaling pathway inhibition: mechanisms and potential use as a biomarker. Semin Nephrol. 2010 Nov; 30(6):591-601. PMID: 21146124.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  30. Robinson ES, Khankin EV, Choueiri TK, Dhawan MS, Rogers MJ, Karumanchi SA, Humphreys BD. Suppression of the nitric oxide pathway in metastatic renal cell carcinoma patients receiving vascular endothelial growth factor-signaling inhibitors. Hypertension. 2010 Dec; 56(6):1131-6. PMID: 20956731.
    Citations: 39     Fields:    Translation:Humans
  31. Shapiro NI, Khankin EV, Van Meurs M, Shih SC, Lu S, Yano M, Castro PR, Maratos-Flier E, Parikh SM, Karumanchi SA, Yano K. Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol. 2010 Jul 01; 185(1):517-24. PMID: 20519646; PMCID: PMC3997057.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  32. Khankin EV, Royle C, Karumanchi SA. Placental vasculature in health and disease. Semin Thromb Hemost. 2010 Apr; 36(3):309-20. PMID: 20490981.
    Citations: 15     Fields:    Translation:Humans
  33. Steinberg G, Lee C, Rauh-Hain JA, Ecker J, Khankin EV, Hsu CD, Cohen B, Rana S, Karumanchi SA, Thadhani R, Hacker MR, Lim KH. Early-pregnancy soluble Fas levels in idiopathic small-for-gestational-age pregnancies. Am J Obstet Gynecol. 2010 Mar; 202(3):299.e1-7. PMID: 20207247.
    Citations: 3     Fields:    Translation:Humans
  34. Khankin EV, Mutter WP, Tamez H, Yuan HT, Karumanchi SA, Thadhani R. Soluble erythropoietin receptor contributes to erythropoietin resistance in end-stage renal disease. PLoS One. 2010 Feb 16; 5(2):e9246. PMID: 20169072.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  35. Thadhani R, Powe CE, Tjoa ML, Khankin E, Ye J, Ecker J, Schneyer A, Karumanchi SA. First-trimester follistatin-like-3 levels in pregnancies complicated by subsequent gestational diabetes mellitus. Diabetes Care. 2010 Mar; 33(3):664-9. PMID: 20007937.
    Citations: 16     Fields:    Translation:Humans
  36. Weiner D, Khankin EV, Levy Y, Reznick AZ. Effects of cigarette smoke borne reactive nitrogen species on salivary alpha-amylase activity and protein modifications. J Physiol Pharmacol. 2009 Nov; 60 Suppl 5:127-32. PMID: 20134053.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  37. Yuan HT, Khankin EV, Karumanchi SA, Parikh SM. Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. Mol Cell Biol. 2009 Apr; 29(8):2011-22. PMID: 19223473.
    Citations: 160     Fields:    Translation:HumansCells
  38. Steinberg G, Rauh-Hain JA, Ecker J, Lee C, Khankin EV, Cohen B,Rana S, Karumanchi SA, Thadhani RI, Lim KH. Second trimester serum soluble Fas (sFas) levels are lower in SGA pregnancies. 2009.
  39. Steinberg G, Khankin EV, Karumanchi SA. Angiogenic factors and preeclampsia. Thromb Res. 2009; 123 Suppl 2:S93-9. PMID: 19217486.
    Citations: 17     Fields:    Translation:Humans
  40. Steinberg G, Khankin EV, Karumanchi SA. Angiogenic Factors and Preeclampsia. Seminars in Thrombosis and Hemostasis. 2009; Accepted for Publication.
  41. Weiner D, Levy Y, Khankin EV, Reznick AZ. Inhibition of salivary amylase activity by cigarette smoke aldehydes. Journal of Physiology and Pharmacology. 2009; 59(S), Accepted for Publicatio.
  42. Weiner D, Levy Y, Khankin EV, Reznick AZ. Inhibition of salivary amylase activity by cigarette smoke aldehydes. J Physiol Pharmacol. 2008 Dec; 59 Suppl 6:727-37. PMID: 19218700.
    Citations: 9     Fields:    Translation:HumansAnimals
  43. Hai-Tao Yuan, Eliyahu V. Khankin, S. Ananth Karumanchi. Protective effects of Tie2-agonistic antibodies in Folic Acid induced nephropathy model. 2008.
  44. Walter P. Mutter, Hector Tamez, Eliyahu V. Khankin, S. Ananth Karumanchi. Soluble Erythropoietin receptor levels predict subsequent Erythropoietin dose in hemodialysis patients. 2008.
  45. Eliyahu V. Khankin, Samir M. Parikh, Isaac E. Stillman, Michael J Somers, S. Ananth Karumanchi. Animal model of Minimal Change Disease. 2008.
  46. Nakhoul F, Khankin E, Yaccob A, Kawachi H, Karram T, Awaad H, Nakhoul N, Hoffman A, Abassi Z. Eplerenone potentiates the antiproteinuric effects of enalapril in experimental nephrotic syndrome. Am J Physiol Renal Physiol. 2008 Mar; 294(3):F628-37. PMID: 18094029.
    Citations: 6     Fields:    Translation:Animals
  47. Blum S, Nakhoul F, Khankin E, Abassi Z. Renal slit diaphragm--the open zipper and the failing heart. Isr Med Assoc J. 2007 Feb; 9(2):107-11. PMID: 17348483.
    Citations: 2     Fields:    Translation:HumansCells
  48. Rana S, Rauh-Hain A, Ecker J, Shivalingappa V, Khankin E, Karumanchi A, Thadhani R. First trimester angiogenic proteins and the risk of intrauterine fetal demise. 2007.
  49. Abassi Z, Nakhoul F, Khankin E, Reisner SA, Yigla M. Pulmonary hypertension in chronic dialysis patients with arteriovenous fistula: pathogenesis and therapeutic prospective. Curr Opin Nephrol Hypertens. 2006 Jul; 15(4):353-60. PMID: 16775448.
    Citations: 22     Fields:    Translation:Humans
  50. Nakhoul F, Khankin E, Ramadan R, Karam T, Awad H, Yaccob A, Abassi Z. Anti-proteinuric effects of Eplerenone, a Selective Aldosterone Blocker in experimental Nephrotic Syndrome: Correlation with Nephrin and Podocin abundance. 2006.
  51. Nakhoul F, Ramadan R, Khankin E, Yaccob A, Kositch Z, Lewin M, Assady S, Abassi Z. Glomerular abundance of nephrin and podocin in experimental nephrotic syndrome: different effects of antiproteinuric therapies. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F880-90. PMID: 15942045.
    Citations: 9     Fields:    Translation:Animals
  52. Khankin E, Knechtel L, Tobe S. Current Trends in Continuous Renal Replacement Therapy – Ontario Region. 2005.
  53. Nakhoul F, Lotan R, Aronson D, Roy A, Khankin E, Miller B, Levy A. Kidney and eye disease in diabetic mice genetically modified at the haptoglobin locus. 2005.
  54. Nakhoul F, Ramadan R, Assady S, Khankin E, Lewin M, Abassi Z. Glomerular abundance of nephrin and podocin in experimental nephrotic syndrome: different effects of anti-proteinuric therapies. 2005.
  55. Nakhoul F, Abassi Z, Plawner M, Khankin E, Ramadan R, Lanir N, Brenner B, Green J. Comparative study of response to treatment with supraphysiologic doses of B-vitamins in hyperhomocysteinemic hemodialysis patients. Isr Med Assoc J. 2004 Apr; 6(4):213-7. PMID: 15115259.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  56. Gelman R, Khankin E, Ben-Itzhak A, Finkelshtein R, Nakhoul F. Herpes simplex viral infection presenting as fever of unknown origin and esophagitis in a renal transplant patient. Isr Med Assoc J. 2002 Nov; 4(11 Suppl):970-1. PMID: 12455194.
    Citations:    Fields:    Translation:Humans
  57. Armaly Z, Khankin E, Ramadan R, Ben-Itzhak O, Guralnik L, Green J, Nakhoul F. Two cases of renal mucormycosis in renal transplanted patients. Clin Nephrol. 2002 Sep; 58(3):247-9. PMID: 12356197.
    Citations: 4     Fields:    Translation:Humans
  58. Blazer S, Khankin E, Segev Y, Ofir R, Yalon-Hacohen M, Kra-Oz Z, Gottfried Y, Larisch S, Skorecki KL. High glucose-induced replicative senescence: point of no return and effect of telomerase. Biochem Biophys Res Commun. 2002 Aug 09; 296(1):93-101. PMID: 12147232.
    Citations: 35     Fields:    Translation:HumansCells
  59. Nakhoul F, Gelman R, Green J, Khankin E, Baruch Y. Lamivudine therapy for severe acute hepatitis B virus infection after renal transplantation: case report and literature review. Transplant Proc. 2001 Sep; 33(6):2948-9. PMID: 11543804.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.