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David Murray Systrom, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K24HL004022 (SYSTROM, DAVID M) Jan 1, 2000 - Nov 30, 2004
    NIH/NHLBI
    SKELETAL MUSCLE DYSFUNCTION IN COPD
    Role: Principal Investigator
  2. K08HL002593 (SYSTROM, DAVID M) Dec 31, 1991 - Nov 30, 1994
    NIH/NHLBI
    ANAEROBIC THRESHOLD DURING EXERCISE
    Role: Principal Investigator
  3. M01RR001066 (SLAVIN, PETER L) Feb 1, 1978 - May 31, 2008
    NIH/NCRR
    General Clinical Research Center
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kohli P, Kelly VJ, Kehl EG, Rodriguez-Lopez J, Hibbert KA, Kone M, Systrom DM, Waxman AB, Venegas JG, Channick R, Winkler T, Harris RS. Perfusion Imaging Distinguishes Exercise Pulmonary Arterial Hypertension at Rest. Am J Respir Crit Care Med. 2019 Jun 01; 199(11):1438-1441. PMID: 30811948.
    Citations:    
  2. Singh I, Oliveira RKF, Naeije R, Rahaghi FN, Oldham W, Systrom DM, Waxman AB. Pulmonary Vascular Distensibility and Early Pulmonary Vascular Remodeling in Pulmonary Hypertension. Chest. 2019 May 20. PMID: 31121149.
    Citations:    
  3. Singh I, Rahaghi FN, Naeije R, Oliveira RKF, Systrom DM, Waxman AB. Right Ventricular-Arterial Uncoupling During Exercise in Heart Failure With Preserved Ejection Fraction: Role of Pulmonary Vascular Dysfunction. Chest. 2019 May 16. PMID: 31103695.
    Citations:    
  4. Platz E, Merz A, Silverman M, Lewis E, Groarke JD, Waxman A, Systrom D. Association between lung ultrasound findings and invasive exercise haemodynamics in patients with undifferentiated dyspnoea. ESC Heart Fail. 2019 02; 6(1):202-207. PMID: 30474936.
    Citations:    Fields:    
  5. Oliveira RKF, Ota-Arakaki JS, Gomes PS, Gimenez A, Messina CMS, Ramos RP, Ferreira EVM, Systrom DM, Pereira CAC. Pulmonary haemodynamics and mortality in chronic hypersensitivity pneumonitis. Eur Respir J. 2018 06; 51(6). PMID: 29622570.
    Citations:    Fields:    
  6. McCabe C, Oliveira RKF, Rahaghi F, Faria-Urbina M, Howard L, Axell RG, Priest AN, Waxman AB, Systrom DM. Right ventriculo-arterial uncoupling and impaired contractile reserve in obese patients with unexplained exercise intolerance. Eur J Appl Physiol. 2018 Jul; 118(7):1415-1426. PMID: 29713818.
    Citations: 1     Fields:    Translation:Humans
  7. Oldham WM, Oliveira RKF, Wang RS, Opotowsky AR, Rubins DM, Hainer J, Wertheim BM, Alba GA, Choudhary G, Tornyos A, MacRae CA, Loscalzo J, Leopold JA, Waxman AB, Olschewski H, Kovacs G, Systrom DM, Maron BA. Network Analysis to Risk Stratify Patients With Exercise Intolerance. Circ Res. 2018 Mar 16; 122(6):864-876. PMID: 29437835.
    Citations:    Fields:    
  8. Faria-Urbina M, Oliveira RKF, Segrera SA, Lawler L, Waxman AB, Systrom DM. Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car? Pulm Circ. 2018 Jan-Mar; 8(1):2045893218755325. PMID: 29309261.
    Citations: 1     
  9. Huang W, Oliveira RKF, Lei H, Systrom DM, Waxman AB. Pulmonary Vascular Resistance During Exercise Predicts Long-Term Outcomes in Heart Failure With Preserved Ejection Fraction. J Card Fail. 2018 Mar; 24(3):169-176. PMID: 29180305.
    Citations: 1     Fields:    Translation:Humans
  10. Hemnes AR, Beck GJ, Newman JH, Abidov A, Aldred MA, Barnard J, Berman Rosenzweig E, Borlaug BA, Chung WK, Comhair SAA, Erzurum SC, Frantz RP, Gray MP, Grunig G, Hassoun PM, Hill NS, Horn EM, Hu B, Lempel JK, Maron BA, Mathai SC, Olman MA, Rischard FP, Systrom DM, Tang WHW, Waxman AB, Xiao L, Yuan JX, Leopold JA. PVDOMICS: A Multi-Center Study to Improve Understanding of Pulmonary Vascular Disease Through Phenomics. Circ Res. 2017 10 27; 121(10):1136-1139. PMID: 29074534.
    Citations: 6     Fields:    
  11. Guazzi M, Bandera F, Ozemek C, Systrom D, Arena R. Cardiopulmonary Exercise Testing: What Is its Value? J Am Coll Cardiol. 2017 Sep 26; 70(13):1618-1636. PMID: 28935040.
    Citations: 5     Fields:    Translation:Humans
  12. van Riel ACMJ, Systrom DM, Oliveira RKF, Landzberg MJ, Mulder BJM, Bouma BJ, Maron BA, Shah AM, Waxman AB, Opotowsky AR. Hemodynamic and metabolic characteristics associated with development of a right ventricular outflow tract pressure gradient during upright exercise. PLoS One. 2017; 12(6):e0179053. PMID: 28636647.
    Citations:    Fields:    Translation:Humans
  13. Oliveira RKF, Faria-Urbina M, Maron BA, Santos M, Waxman AB, Systrom DM. Functional impact of exercise pulmonary hypertension in patients with borderline resting pulmonary arterial pressure. Pulm Circ. 2017 Jul-Sep; 7(3):654-665. PMID: 28895507.
    Citations: 3     
  14. Huang W, Resch S, Oliveira RK, Cockrill BA, Systrom DM, Waxman AB. Invasive cardiopulmonary exercise testing in the evaluation of unexplained dyspnea: Insights from a multidisciplinary dyspnea center. Eur J Prev Cardiol. 2017 07; 24(11):1190-1199. PMID: 28506086.
    Citations: 3     Fields:    Translation:Humans
  15. Segrera SA, Lawler L, Opotowsky AR, Systrom D, Waxman AB. Open label study of ambrisentan in patients with exercise pulmonary hypertension. Pulm Circ. 2017 Apr-Jun; 7(2):531-538. PMID: 28597763.
    Citations: 3     
  16. van Riel AC, Opotowsky AR, Santos M, Rivero JM, Dhimitri A, Mulder BJ, Bouma BJ, Landzberg MJ, Waxman AB, Systrom DM, Shah AM. Accuracy of Echocardiography to Estimate Pulmonary Artery Pressures With Exercise: A Simultaneous Invasive-Noninvasive Comparison. Circ Cardiovasc Imaging. 2017 Apr; 10(4). PMID: 28360262.
    Citations: 4     Fields:    Translation:Humans
  17. van Riel AC, Systrom DM, Oliveira RK, Landzberg MJ, Mulder BJ, Bouma BJ, Maron BA, Shah AM, Waxman AB, Opotowsky AR. Development of a Right Ventricular Outflow Tract Gradient During Upright Exercise: A Hemodynamic Observation. J Am Coll Cardiol. 2017 02 07; 69(5):595-597. PMID: 28153114.
    Citations: 1     Fields:    
  18. Biering-Sørensen T, Santos M, Rivero J, McCullough SD, West E, Opotowsky AR, Waxman AB, Systrom DM, Shah AM. Left ventricular deformation at rest predicts exercise-induced elevation in pulmonary artery wedge pressure in patients with unexplained dyspnoea. Eur J Heart Fail. 2017 01; 19(1):101-110. PMID: 27878925.
    Citations: 4     Fields:    Translation:Humans
  19. Tikkanen AU, Rhodes J, Landzberg M, Bhatt A, Systrom DM, Waxman A, Moko L, Bradley R, Crouter S, Opotowsky A. Poster 26 A Randomized Trial of Cardiac Rehabilitation for Adolescents and Adults with Congenital Heart Disease. PM R. 2016 Sep; 8(9S):S169. PMID: 27672794.
    Citations: 1     Fields:    
  20. Moniodis AE, Ginns JN, Systrom DM. Dyspnea and an Arteriovenous Fistula. Ann Am Thorac Soc. 2016 Aug; 13(8):1419-23. PMID: 27509156.
    Citations:    Fields:    Translation:Humans
  21. Oliveira RK, Waxman AB, Agarwal M, Badr Eslam R, Systrom DM. Pulmonary haemodynamics during recovery from maximum incremental cycling exercise. Eur Respir J. 2016 07; 48(1):158-67. PMID: 27126692.
    Citations: 4     Fields:    Translation:Humans
  22. Oldham WM, Lewis GD, Opotowsky AR, Waxman AB, Systrom DM. Unexplained exertional dyspnea caused by low ventricular filling pressures: results from clinical invasive cardiopulmonary exercise testing. Pulm Circ. 2016 Mar; 6(1):55-62. PMID: 27162614.
    Citations: 4     
  23. Oliveira RK, Agarwal M, Tracy JA, Karin AL, Opotowsky AR, Waxman AB, Systrom DM. Age-related upper limits of normal for maximum upright exercise pulmonary haemodynamics. Eur Respir J. 2016 Apr; 47(4):1179-88. PMID: 26677941.
    Citations: 12     Fields:    Translation:Humans
  24. Berry NC, Manyoo A, Oldham WM, Stephens TE, Goldstein RH, Waxman AB, Tracy JA, Leary PJ, Leopold JA, Kinlay S, Opotowsky AR, Systrom DM, Maron BA. Protocol for exercise hemodynamic assessment: performing an invasive cardiopulmonary exercise test in clinical practice. Pulm Circ. 2015 Dec; 5(4):610-8. PMID: 26697168.
    Citations: 6     
  25. Santos M, Rivero J, McCullough SD, West E, Opotowsky AR, Waxman AB, Systrom DM, Shah AM. E/e' Ratio in Patients With Unexplained Dyspnea: Lack of Accuracy in Estimating Left Ventricular Filling Pressure. Circ Heart Fail. 2015 Jul; 8(4):749-56. PMID: 26067855.
    Citations: 12     Fields:    Translation:Humans
  26. White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY. Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension. EMBO Mol Med. 2015 Jun; 7(6):695-713. PMID: 25825391.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  27. Nathan AS, Loukas B, Moko L, Wu F, Rhodes J, Rathod RH, Systrom DM, Ubeda Tikkanen A, Shafer K, Lewis GD, Landzberg MJ, Opotowsky AR. Exercise oscillatory ventilation in patients with Fontan physiology. Circ Heart Fail. 2015 Mar; 8(2):304-11. PMID: 25550441.
    Citations: 3     Fields:    Translation:Humans
  28. Santos M, Opotowsky AR, Shah AM, Tracy J, Waxman AB, Systrom DM. Central cardiac limit to aerobic capacity in patients with exertional pulmonary venous hypertension: implications for heart failure with preserved ejection fraction. Circ Heart Fail. 2015 Mar; 8(2):278-85. PMID: 25550438.
    Citations: 10     Fields:    Translation:Humans
  29. Santos M, Systrom D, Epstein SE, John A, Ruiz G, Landzberg MJ, Opotowsky AR. Impaired exercise capacity following atrial septal defect closure: an invasive study of the right heart and pulmonary circulation. Pulm Circ. 2014 Dec; 4(4):630-7. PMID: 25610599.
    Citations: 3     
  30. Opotowsky AR, Halpern D, Kulik TJ, Systrom DM, Wu F. Inadequate venous return as a primary cause for Fontan circulatory limitation. J Heart Lung Transplant. 2014 Nov; 33(11):1194-6. PMID: 25169956.
    Citations: 1     Fields:    Translation:Humans
  31. Opotowsky AR, Landzberg MJ, Earing MG, Wu FM, Triedman JK, Casey A, Ericson DA, Systrom D, Paridon SM, Rhodes J. Abnormal spirometry after the Fontan procedure is common and associated with impaired aerobic capacity. Am J Physiol Heart Circ Physiol. 2014 Jul 01; 307(1):H110-7. PMID: 24791784.
    Citations: 8     Fields:    Translation:Humans
  32. Boerrigter BG, Waxman AB, Westerhof N, Vonk-Noordegraaf A, Systrom DM. Measuring central pulmonary pressures during exercise in COPD: how to cope with respiratory effects. Eur Respir J. 2014 May; 43(5):1316-25. PMID: 24177003.
    Citations: 10     Fields:    Translation:Humans
  33. McCormack SE, McCarthy MA, Harrington SG, Farilla L, Hrovat MI, Systrom DM, Thomas BJ, Torriani M, McInnis K, Grinspoon SK, Fleischman A. Effects of exercise and lifestyle modification on fitness, insulin resistance, skeletal muscle oxidative phosphorylation and intramyocellular lipid content in obese children and adolescents. Pediatr Obes. 2014 Aug; 9(4):281-91. PMID: 23801526.
    Citations: 7     Fields:    Translation:HumansCells
  34. Maron BA, Cockrill BA, Waxman AB, Systrom DM. The invasive cardiopulmonary exercise test. Circulation. 2013 Mar 12; 127(10):1157-64. PMID: 23479667.
    Citations: 14     Fields:    Translation:Humans
  35. Hammerness P, Zusman R, Systrom D, Surman C, Baggish A, Schillinger M, Shelley-Abrahamson R, Wilens TE. A cardiopulmonary study of lisdexamfetamine in adults with attention-deficit/hyperactivity disorder. World J Biol Psychiatry. 2013 May; 14(4):299-306. PMID: 22559155.
    Citations: 8     Fields:    Translation:Humans
  36. Saggar R, Lewis GD, Systrom DM, Champion HC, Naeije R, Saggar R. Pulmonary vascular responses to exercise: a haemodynamic observation. Eur Respir J. 2012 Feb; 39(2):231-4. PMID: 22298608.
    Citations: 7     Fields:    Translation:Humans
  37. Murphy RM, Shah RV, Malhotra R, Pappagianopoulos PP, Hough SS, Systrom DM, Semigran MJ, Lewis GD. Exercise oscillatory ventilation in systolic heart failure: an indicator of impaired hemodynamic response to exercise. Circulation. 2011 Sep 27; 124(13):1442-51. PMID: 21875912.
    Citations: 17     Fields:    Translation:Humans
  38. McCormack SE, McCarthy MA, Farilla L, Hrovat MI, Systrom DM, Grinspoon SK, Fleischman A. Skeletal muscle mitochondrial function is associated with longitudinal growth velocity in children and adolescents. J Clin Endocrinol Metab. 2011 Oct; 96(10):E1612-8. PMID: 21832105.
    Citations: 1     Fields:    Translation:HumansCells
  39. Baggish AL, Hale A, Weiner RB, Lewis GD, Systrom D, Wang F, Wang TJ, Chan SY. Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training. J Physiol. 2011 Aug 15; 589(Pt 16):3983-94. PMID: 21690193.
    Citations: 97     Fields:    Translation:Humans
  40. Lewis GD, Murphy RM, Shah RV, Pappagianopoulos PP, Malhotra R, Bloch KD, Systrom DM, Semigran MJ. Pulmonary vascular response patterns during exercise in left ventricular systolic dysfunction predict exercise capacity and outcomes. Circ Heart Fail. 2011 May; 4(3):276-85. PMID: 21292991.
    Citations: 24     Fields:    Translation:Humans
  41. Makimura H, Stanley TL, Sun N, Hrovat MI, Systrom DM, Grinspoon SK. The association of growth hormone parameters with skeletal muscle phosphocreatine recovery in adult men. J Clin Endocrinol Metab. 2011 Mar; 96(3):817-23. PMID: 21177784.
    Citations: 4     Fields:    Translation:HumansCells
  42. Makimura H, Stanley TL, Sun N, Connelly JM, Hemphill LC, Hrovat MI, Systrom DM, Grinspoon SK. Increased skeletal muscle phosphocreatine recovery after sub-maximal exercise is associated with increased carotid intima-media thickness. Atherosclerosis. 2011 Mar; 215(1):214-7. PMID: 21185022.
    Citations:    Fields:    Translation:HumansCells
  43. Fleischman A, Makimura H, Stanley TL, McCarthy MA, Kron M, Sun N, Chuzi S, Hrovat MI, Systrom DM, Grinspoon SK. Skeletal muscle phosphocreatine recovery after submaximal exercise in children and young and middle-aged adults. J Clin Endocrinol Metab. 2010 Sep; 95(9):E69-74. PMID: 20554709.
    Citations: 12     Fields:    Translation:HumansCells
  44. Lewis GD, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC, Souza A, Cheng S, McCabe EL, Yang E, Shi X, Deo R, Roth FP, Asnani A, Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, Sabatine MS, Clish CB, Gerszten RE. Metabolic signatures of exercise in human plasma. Sci Transl Med. 2010 May 26; 2(33):33ra37. PMID: 20505214.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  45. Gregory D. Lewis, Laurie Farrell, Amanda Souza, Maryann Martinovic, David M. Systrom, Marc J. Semigran, Malissa J. Wood, Steven A. Carr, Marc S. Sabatine, Clary B. Clish, and Robert E. Gerszten. Novel Metabolic Signatures of Human Exercise Performance. TBA. 2010.
  46. Baggish AL, Fulco CS, Muza S, Rock PB, Beidleman B, Cymerman A, Yared K, Fagenholz P, Systrom D, Wood MJ, Weyman AE, Picard MH, Harris NS. The impact of moderate-altitude staging on pulmonary arterial hemodynamics after ascent to high altitude. High Alt Med Biol. 2010; 11(2):139-45. PMID: 20586598.
    Citations:    Fields:    Translation:Humans
  47. Fleischman A, Kron M, Systrom DM, Hrovat M, Grinspoon SK. Mitochondrial function and insulin resistance in overweight and normal-weight children. J Clin Endocrinol Metab. 2009 Dec; 94(12):4923-30. PMID: 19846731.
    Citations: 24     Fields:    Translation:HumansCellsPHPublic Health
  48. Systrom DM, Oudiz RJ, Naeije R, Steen VD, Champion HC. Pulmonary hypertension roundtable: identifying the key issues in exercise testing. Adv Pulm Hypertension. 2009; 7:412-7.
  49. Troy P, Lewis G, Janocha AJ, Van Horn T, Erzurum S, Waxman AB, Systrom D. Abnormal transpulmonary metabolite flux in exercise induced pulmonary arterial hypertension. Am J Respir Crit Care Med. 2009; 179:A4131.
  50. Tolle JJ, Waxman AB, Van Horn TL, Pappagianopoulos PP, Systrom DM. Exercise-induced pulmonary arterial hypertension. Circulation. 2008 Nov 18; 118(21):2183-9. PMID: 18981305.
    Citations: 44     Fields:    Translation:Humans
  51. Lewis GD, Shah RV, Pappagianopolas PP, Systrom DM, Semigran MJ. Determinants of ventilatory efficiency in heart failure: the role of right ventricular performance and pulmonary vascular tone. Circ Heart Fail. 2008 Nov; 1(4):227-33. PMID: 19808296.
    Citations: 26     Fields:    Translation:Humans
  52. Tolle J, Waxman A, Systrom D. Impaired systemic oxygen extraction at maximum exercise in pulmonary hypertension. Med Sci Sports Exerc. 2008 Jan; 40(1):3-8. PMID: 18091026.
    Citations: 8     Fields:    Translation:HumansCells
  53. Tolle JJ, Gordan PL, Lewis GD, Farrar C, Hrovat M, Pappagianopoulos P, Systrom D. Skeletal muscle mitochodrial dysfunction in pulmonary arterial hypertension. Am j Respir Crit Care Med. 2008; 177:A293.
  54. Lewis GD, Shah R, Shahzad K, Camuso JM, Pappagianopoulos PP, Hung J, Tawakol A, Gerszten RE, Systrom DM, Bloch KD, Semigran MJ. Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension. Circulation. 2007 Oct 02; 116(14):1555-62. PMID: 17785618.
    Citations: 119     Fields:    Translation:Humans
  55. Fleischman A, Johnsen S, Systrom DM, Hrovat M, Farrar CT, Frontera W, Fitch K, Thomas BJ, Torriani M, Côté HC, Grinspoon SK. Effects of a nucleoside reverse transcriptase inhibitor, stavudine, on glucose disposal and mitochondrial function in muscle of healthy adults. Am J Physiol Endocrinol Metab. 2007 Jun; 292(6):E1666-73. PMID: 17284576.
    Citations: 51     Fields:    Translation:HumansCells
  56. Gordan P, Tolle J, Systrom DM. Skeletal Muscle Ventilatory Chemoreflex during Exercise with Repetitive Partial Circulatory Occlusion. Am J Respir Crit Care Med. 2007; 175:4396.
  57. Fleischman A, Johnsen S, Systrom DM, Hrovat H. Farrar C. Frontera W, Fitch K. Thomas BJ, Torriani M, Cote HCF, Grinspoon SK. Alterations in Insulin Sensitivity and Mitochondria by a Nucleoside Reverse Transcriptase Inhibitor in Healthy Adults. Am J Physiol. 2007; 292(6):E1666-73.
  58. Oelberg DA, Hrovat MI, Systrom DM. Ventilatory control and skeletal muscle pHi during recovery from exercise in the human. 2007; Submitted.
  59. Lweis GD, Shin J, Systrom DM, Bloch KD, Semigran MJ. The emerging role of PDE5 inhibition in heart failure. BMC Pharmacology. 2007; 7:S10.
  60. Lewis GD, DiSalvo T, Systrom DM. Non-invasively measured cardiac output augmentation predicts prognosis in advanced heart failure. 2007; Submitted.
  61. Lewis GD, Lachmann J, Camuso J, Lepore JJ, Shin J, Martinovic ME, Systrom DM, Bloch KD, Semigran MJ. Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure. Circulation. 2007 Jan 02; 115(1):59-66. PMID: 17179022.
    Citations: 83     Fields:    Translation:Humans
  62. J.J. Tolle, MD, D.M. Systrom, MD, J.C. Wain, MD, L.C. Ginns, MD. Massachusetts General Hospita, Harvard Medical School, Boston, MA. Exercise Limitation Differs in Recipients of Lung Transplantation from Living vs. Deceased Donors in Cystic Fibrosis. Am J Respir Crit Care Med. 2006.
  63. LaRaia AV, Lewis GD, Pappagianopoulos PP, Hrovat MI, Farrar C, Systrom DM . Relationship between Respiratory Drive and Skeletal Muscle pHi during Exercise by 31PMRS. Am J Respir Crit Care Med. 2006; A200.
  64. P.L. Gordan, MD, J.J. Tolle, MD, P.P. Pappagianopoulos, D.M. Systrom, MD. Pulmonary and Critical Care Unit. Massachusetts General Hospital, Harvard Medical School, Boston, MA. Skeletal Muscle Ventilatory Chemoreflex during Exercise with Repetitive Partial Circulatory Occlusion. Am J Respir Crit Care Med. 2006.
  65. D.A. Oelberg, MD, A.L. Abraham, MD, D.L. Prisco, MD, P.M. DiLauro, RN, J.J. Chronakos, MD, D.M. Systrom, MD, Danbury, CT, Boston, MA. Improved Exercise Performance in Patients With COPD Using Partially Ischemic Leg Training. Am J Respir Crit Care Med. 2006; A220.
  66. J.J. Tolle, MD, A.B. Waxman, MD. D.M. Systrom, MD. Massachusetts General Hospital, Harvard Medical School, Boston, MA. Exercise-Induced Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2006.
  67. J.J. Tolle, MD, A.B. Waxman, MD, D.M. Systrom, MD. Massachusetts General Hospital, Harvard Medical School, Boston, MA. Abnormal Systemic O2 Extraction During Incremental Exercise in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2006.
  68. A.V. LaRaia, MD, G.D. Lewis, MD, P.P. Pappagianopoulos, M.D., M.I. Hrovat, PhD., C. Farrar, PhD, D.M. Systrom, MD, Boston, MA. Relationship Between Respiratory Drive and Skeletal Muscle pHi During Exercise by 31PMRS. Am J Respir Crit Care Med. 2006; A2001.
  69. Kao AY, Munandar R, Ferrara SL, Systrom DM, Sheridan RL, Cash SS, Ryan ET. Case records of the Massachusetts General Hospital. Case 19-2005. A 17-year-old girl with respiratory distress and hemiparesis after surviving a tsunami. N Engl J Med. 2005 Jun 23; 352(25):2628-36. PMID: 15972870.
    Citations: 2     Fields:    Translation:Humans
  70. Systrom DM, Wittram C. Case records of the Massachusetts General Hospital. Case 9-2005. A 67-year-old man with acute respiratory failure. N Engl J Med. 2005 Mar 24; 352(12):1238-46. PMID: 15788501.
    Citations: 3     Fields:    Translation:HumansCells
  71. Systrom DM, Kao A, Sheridan R, Cash S, Ryan E, Ferrara S. A 17-year-old girl with respiratory distress and hemiparesis after surviving a tsunami. N Engl J Med. 2005; 352:2628-36.
  72. Systrom DM, Wittram C. A man with acute respiratory failure. N Engl J Med. 2005; 352:1238-46.
  73. Systrom DM, Kao A, Sheridan R, Cash S, Ryan E, Ferrara S. A 17-year old girl with respiratory distress and hemiparesis after survivng a tsunami. N Engl J Med. 2005; 352:2628-36.
  74. J.J. Tolle, MD, S. Celikel, MD, D.M. Systrom, MD, Boston, MA. Mixed Venous PO2 and Pulmonary Hypertension During Exercise. Am J Respir Crit Care Med. 2005; A496.
  75. Systrom DM, Witram C. . A man with acute respiratory failure. N Engl J Med. 2005; 1238-46.
  76. J.J. Tolle, MD, A.B. Waxman, MD, PhD, D.M. Systrom, MD, Boston, MA. Abnormal Systemic O2 Extraction During Incremental Exercise in Pulmonary Hypertension. Am J Respir Crit Care Med. 2005; A498.
  77. Systrom DM. Case Records of the Massachusetts General Hospital. N Engl J Med. 2004; In Press.
  78. Systrom DM, Montes De Oca M, Fessler HE, Schols A. COPD: Extrapulmonary manifestation. 2004; 169:A770.
  79. Systrom DM. Deep vein thrombosis and pulmonary thromboembolism. In: Fishman, Hoffman, Klausner, Thaler, eds. Medicine. 2004; 117-24.
  80. Systrom DM. Respiratory failure. In: Fishman, Hoffman, Klausner, Thaler, eds. Medicine. 2004; 129-34.
  81. Systrom DM, et al. Pulmonary. In: Sabatine, ed. Pocket Medicine. 2004; 2-1 - 2-22.
  82. Systrom DM. Asthma. In: Fishman, Hoffman, Klausner, Thaler, eds. Medicine. 2004; 97-104.
  83. Lewis GD, DiSalvo T, Systrom DM. Non-invasively measured cardiac output augmentation predicts prognosis in advanced heart failure. Submitted. 2004.
  84. Oelberg DA, Hrovat MI, Systrom DM. Ventilatory control and skeletal muscle pHi during recovery from exercise in the human. Submitted. 2004.
  85. Markowitz DH, Kacmarek R, Systrom DM. Effect of inhaled nitric oxide on right heart function during exercise. Submitted. 2004.
  86. Markowitz DH, Systrom DM. Diagnosis of pulmonary vascular limit to exercise by cardiopulmonary exercise testing. J Heart Lung Transplant. 2004 Jan; 23(1):88-95. PMID: 14734132.
    Citations: 7     Fields:    Translation:Humans
  87. Systrom DM. Chronic obstructive pulmonary disease. In: Fishman, Hoffman, Klausner, Thaler, eds. Medicine. 2004; 105-10.
  88. Tantisira KG, Systrom DM, Ginns LC. An elevated breathing reserve index at the lactate threshold is a predictor of mortality in patients with cystic fibrosis awaiting lung transplantation. Am J Respir Crit Care Med. 2002 Jun 15; 165(12):1629-33. PMID: 12070064.
    Citations: 3     Fields:    Translation:Humans
  89. Kazemi H, Systrom D. Carbon dioxide pressure-concentration relationship in arterial and mixed venous blood. J Appl Physiol (1985). 2001 Nov; 91(5):2413; author reply 2413-4. PMID: 11706821.
    Citations:    Fields:    Translation:Humans
  90. Systrom DM, Hales CA. The role of cardiopulmonary exercise testing in patients with pulmonary vascular disease. In: Progress In Respiratory Research: Clincial Exercise Testing, ed:. Weisman IM, Zeballos RJ. 2001; 32:200-4.
  91. Systrom DM, Hales CA. The role of cardiopulmonary exercise testing in patients with pulmonary vascular disease. In: Progress In Respiratory Research: Clinical Exercise Testing. ed: Weisman IM, Zeballos RJ. 2001; 32.
  92. Systrom DM, Hrovat M, Oelberg D, Kazemi H. Skeletal muscle chemoreflex in exercise ventilatory control. In: Frontiers in Modeling and Control of Breathing: Integration at Molecular, Cellular, and Systems Levels. ed. Poon CS, Kazemi H. 2001; 343-348.
  93. Systrom DM, Hrovat M, Oelberg D, Kazemi H. Skeletal muscle chemoreflex in exercise ventilatory control. Adv Exp Med Biol. 2001; 499:343-8. PMID: 11729905.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  94. Systrom DM, et al. Pulmonary. In: Sabatine, ed. Pocket Medicine. 1st ed. Philadelphia: Lippincpott Williams & Wilkins. 2000; 2.1-2.21.
  95. Systrom DM, et al. Skeletal muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1999; 159:S1-S40.
  96. Oelberg DA, Systrom DM. The skeletal muscle chemoreflex in exercise ventilatory control. In: Kent Pandolf, Nobuakira Takeda and Pawan K. Singal, ed. Adaptation Biology and Medicine. Narosa Publishing House. 1999; 2:236-45.
  97. Systrom DM, Pappagianopoulos P, Fishman RS, Wain JC, Ginns LC. Determinants of abnormal maximum oxygen uptake after lung transplantation for chronic obstructive pulmonary disease. J Heart Lung Transplant. 1998 Dec; 17(12):1220-30. PMID: 9883764.
    Citations: 1     Fields:    Translation:HumansCells
  98. Oelberg DA, Kacmarek RM, Pappagianopoulos PP, Ginns LC, Systrom DM. Ventilatory and cardiovascular responses to inspired He-O2 during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998 Dec; 158(6):1876-82. PMID: 9847281.
    Citations: 10     Fields:    Translation:Humans
  99. Andreu AL, Bruno C, Shanske S, Shtilbans A, Hirano M, Krishna S, Hayward L, Systrom DS, Brown RH, DiMauro S. Missense mutation in the mtDNA cytochrome b gene in a patient with myopathy. Neurology. 1998 Nov; 51(5):1444-7. PMID: 9818877.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  100. Oelberg DA, Systrom DM, Markowitz DH, Zorb SL, Wright C, Wain JC, Ginns LC. Exercise performance in cystic fibrosis before and after bilateral lung transplantation. J Heart Lung Transplant. 1998 Nov; 17(11):1104-12. PMID: 9855450.
    Citations: 2     Fields:    Translation:Humans
  101. Spengler CM, Banzett RB, Systrom DM, Shannon DC, Shea SA. Respiratory sensations during heavy exercise in subjects without respiratory chemosensitivity. Respir Physiol. 1998 Oct; 114(1):65-74. PMID: 9858052.
    Citations: 6     Fields:    Translation:HumansCells
  102. Oelberg DA, Medoff BD, Markowitz DH, Pappagianopoulos PP, Ginns LC, Systrom DM. Systemic oxygen extraction during incremental exercise in patients with severe chronic obstructive pulmonary disease. Eur J Appl Physiol Occup Physiol. 1998 Aug; 78(3):201-7. PMID: 9720997.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  103. Maroni JM, Oelberg DA, Pappagianopoulos P, Boucher CA, Systrom DM. Maximum cardiac output during incremental exercise by first-pass radionuclide ventriculography. Chest. 1998 Aug; 114(2):457-61. PMID: 9726730.
    Citations: 3     Fields:    Translation:Humans
  104. Medoff BD, Oelberg DA, Kanarek DJ, Systrom DM. Breathing reserve at the lactate threshold to differentiate a pulmonary mechanical from cardiovascular limit to exercise. Chest. 1998 Apr; 113(4):913-8. PMID: 9554625.
    Citations: 8     Fields:    Translation:Humans
  105. Oelberg DA, Evans AB, Hrovat MI, Pappagianopoulos PP, Patz S, Systrom DM. Skeletal muscle chemoreflex and pHi in exercise ventilatory control. J Appl Physiol (1985). 1998 Feb; 84(2):676-82. PMID: 9475880.
    Citations: 8     Fields:    Translation:HumansCellsCTClinical Trials
  106. Smoller JW, Pollack MH, Systrom D, Kradin RL. Sertraline effects on dyspnea in patients with obstructive airways disease. Psychosomatics. 1998 Jan-Feb; 39(1):24-9. PMID: 9538672.
    Citations: 25     Fields:    Translation:Humans
  107. Davis B, Systrom DM. Lung abscess: pathogenesis, diagnosis and treatment. Curr Clin Top Infect Dis. 1998; 18:252-73. PMID: 9779359.
    Citations: 2     Fields:    Translation:Humans
  108. Brown R, Systrom D, DiMauro S. A novel G15762A mutation in the mitochondrial cytochrome b gene. Neurology. 1998; 51:1444-47.
  109. Systrom DM, Fishman RS, Wain JC, Ginns LC. Determinants of abnormal maximum oxygen uptake following lung transplantation for chronic obstructive pulmonary disease. J Heart Lung Transpl. 1998; 17:1220-30.
  110. Davis B, Systrom DM. Lung abcess: pathogenesis, diagnosis and treatment. Curr Clin Tpo Infect Dis. 1998; 18:252-73.
  111. Oelberg DA, Systrom DM. Exercise physiology. UpToDate CD ROM card. 1998.
  112. Evans AB, Tsai LW, Oelberg DA, Kazemi H, Systrom DM. Skeletal muscle ECF pH error signal for exercise ventilatory control. J Appl Physiol (1985). 1998 Jan; 84(1):90-6. PMID: 9451622.
    Citations: 2     Fields:    Translation:AnimalsCells
  113. Szekely LA, Oelberg DA, Wright C, Johnson DC, Wain J, Trotman-Dickenson B, Shepard JA, Kanarek DJ, Systrom D, Ginns LC. Preoperative predictors of operative morbidity and mortality in COPD patients undergoing bilateral lung volume reduction surgery. Chest. 1997 Mar; 111(3):550-8. PMID: 9118686.
    Citations: 13     Fields:    Translation:Humans
  114. Evans AB, Al-Himyary AJ, Hrovat MI, Pappagianopoulos P, Wain JC, Ginns LC, Systrom DM. Abnormal skeletal muscle oxidative capacity after lung transplantation by 31P-MRS. Am J Respir Crit Care Med. 1997 Feb; 155(2):615-21. PMID: 9032203.
    Citations: 8     Fields:    Translation:Humans
  115. Systrom DM, et al. Asthma Critical Pathway. Guidelines for in patient asthma management and treatment at MGH. Commissioned by MGH Medical Administration. Utilized throughout MGH. 1997.
  116. Systrom DM. Pulmonary function tests. In; Fishman, Hoffman, Klausner Thaler, eds. Medicine. 4th ed. Philadelphia: JB Lippincpott Co. 1996; 87-9.
  117. Systrom DM. Aspiration syndromes. In: Fishman, Hoffman, Klausner, Thaler, eds. Medicine. 4th ed. Philadelphia: JB Lippincpott Co. 1996; 117-20.
  118. Systrom DM. Deep vein thrombosis and pulmonary thromboembolism. In: Fishman, Hoffman, Klausner, Thaler, eds. Medicine. 4th ed. Philadelphia: JB Lippincpott Co. 1996; 109-15.
  119. Systrom DM. Pulmonary function tests. In: Fishman, Hoffman Klausner Thaler, eds. Medicine. 4th ed. Philadelphia: JB Lippincpott Co. 1996; 87-9.
  120. Systrom DM. Pleural disease. In: In: Fishman, Hoffman, Klausner, Thaler, eds. Medicine 4th ed. Philadelphia: JB Lippincpott Co. 1996; 103-7.
  121. Systrom DM. Chronic obstructive pulmonary disease. In: In: Fishman, Hoffman, Klausner, Thaler, eds. Medicine 4th ed. Philadelphia: JB Lippincpott Co. 1996; 97-101.
  122. Systrom DM. Respiratory failure. In: Fishman, Hoffman, Klausner, Thaler, eds. Medicine. Philadelphia: JB Lippincott Co. 1996; 121-26.
  123. Systrom DM. Hemoptysis. In: Fishman, Hoffman,Klausner thaler, eds. Medicine. 4th ed. Philadelphia: JB Lippincpott Co. 1996; 83-5.
  124. Systrom DM. Chronic obstructive pulmonary disease. In: Fishman, Hoffman, Klausner, Thaler, eds. Medicine. Philadelphia: JB Lippincott Co. 1996; 97-101.
  125. Systrom DM. Respiratory failure. In: Fishman, Hoffman, Klausner, Thaler, eds. Medicine. 4th ed. Philadelphia: JB Lippincpott Co. 1996; 121-26.
  126. Systrom DM. Deep vein thrombosis and pulmonary thromboembolism. In: Fishman, Hoffman, Klausner, Thaler, eds. Medicine. Philadlephia: JB Lippincott Co. 1996; 109-15.
  127. Systrom DM. Asthma. In: Fishman, Hoffman, Klausner, Thaler, eds. Medicine. 4th ed. Philadelphia: JB Lippincpott Co. 1996; 91-6.
  128. Systrom DM. Aspiration syndromes. In: Fishman, Hoffman, Klausner, Thaler, eds. Medicine. Philadelphia: JB Lippincott Co. 1996; 117-20.
  129. Systrom DM. Asthma. In: Fishman, Hoffman, Klausner, Thaler, eds. Medicine. Philadelphia: JB Lippincott Co. 1996; 91-6.
  130. Systrom DM. Hemoptysis. In: Fishman, Hoffman, Klausner Thaler, eds. Medicine. Philadelphia: JB Lippincott Co. 1996; 83-5.
  131. Systrom DM. Pleural disease. In: Fishman, Hoffman, Klausner Thalers, eds. Medicine. Philadelphia: JB Lippincott Co. 1996; 103-7.
  132. Systrom D. Case records of the Massachusetts General Hospital. N Engl J Med. 1995; 332:1700-7.
  133. Herlihy JP, Venegas JG, Systrom DM, Greene RE, McKusick KA, Wain JC, Ginns LC. Expiratory flow pattern following single-lung transplantation in emphysema. Am J Respir Crit Care Med. 1994 Dec; 150(6 Pt 1):1684-9. PMID: 7952633.
    Citations:    Fields:    Translation:Humans
  134. Larson DE, Hesslink RL, Hrovat MI, Fishman RS, Systrom DM. Dietary effects on exercising muscle metabolism and performance by 31P-MRS. J Appl Physiol (1985). 1994 Sep; 77(3):1108-15. PMID: 7836111.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  135. Vaz Fragoso CA, Kacmarek RM, Systrom DM. Improvement in exercise capacity after nocturnal positive pressure ventilation and tracheostomy in a postpoliomyelitis patient. Chest. 1992 Jan; 101(1):254-7. PMID: 1729078.
    Citations: 2     Fields:    Translation:Humans
  136. Fishman RS, Systrom DM. Preoperative cardiopulmonary exercise testing: determining the limit to exercise and predicting outcome after thoracotomy. J Cardiothorac Vasc Anesth. 1991 Dec; 5(6):614-26. PMID: 1768827.
    Citations: 2     Fields:    Translation:Humans
  137. Systrom DM, Fragoso CV, Kanarek DJ, Kazemi H. Ammonium ion and the anaerobic threshold in man. Chest. 1991 May; 99(5):1197-202. PMID: 2019178.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  138. Fragoso CV, Systrom DM. The respiratory system. In: Strauss RH, ed. Sports Medicine. Philadelphia: W.B. Saunders, Co. 1991; 132-45.
  139. Fragoso CV, Systrom DM. The respiratory system. In: Strauss RH, ed. Sports Medicine. 2d Edition. Philadelphia. W.B. Saunders, Co. 1991; 132-45..
  140. Systrom, DM. Case Records of the Massachusetts General Hospital. N Engl J Med. 1991; 325:1155-65.
  141. Systrom D. Case Records of the Massachusetts General Hospital. N Engl J Med. 1991; 325:1155-65.
  142. Systrom DM, Kanarek DJ, Kohler SJ, Kazemi H. 31P nuclear magnetic resonance spectroscopy study of the anaerobic threshold in humans. J Appl Physiol (1985). 1990 May; 68(5):2060-6. PMID: 2361908.
    Citations: 6     Fields:    Translation:HumansCells
  143. Systrom DM. The role of the DLCO in monitoring alveolar proteinosis. J Respir Dis. 1990; 11:671.
  144. Systrom D. Asthma. In: Wilkins EW, ed. Emergency Medicine. Scientific Foundations and Current Practice. Baltimore: Williams and Wilkins. 1989; 149-56.
  145. Systrom, DM. Case records of the Massachusetts General Hospital. N Engl J Med. 1989; 321:375-85.
  146. Systrom DM, Kazemi H. Pulmonary alveolar proteinosis. In: Cherniack RM, ed. Current therapy of respiratory disease. Philadelphia: BC Decker Inc. 1989; 247-9.
  147. Systrom DM. Case Records of the Massachusetts General Hospital. N Engl J Med. 1989; 321:375-85.
  148. Systrom D, Kazemi H. Disorders of ventilatory control. In: Brandstetter R, ed. Pulmonary medicine: problems in primary care. Oraell: Medical Economics Books. 1989; 210-16.
  149. Systrom D. Asthma. In: Wilkins EW, ed. Emergency Medicine. Scientific Foundations and Current Practice. 3D Edition. Baltimore: Williams and Wilkins. 1989; 149-56.
  150. Systrom DM, Kazemi H. . Pulmonary alveolar proteinosis. In: Cherniack RM, ed. Current therapy of respiratory disease. Philadelphia: BC Dekker Inc. 1989; 247-9.
  151. Systrom D, Kazemi H. Disorders of ventilatory control. In: Bradstetter R, ed. Pulmonary medicine: problems in primary care. Oradell: Medical Economics Books. 1989; 210-16.
  152. Blumenstock DA, Systrom D, Hales C, Alpern H, Kazemi H. Pulmonary function of haplotype-matched and mismatched allografts in dogs treated with total-body irradiation, autologous marrow transplantation, methotrexate, and donor blood. Transplantation. 1988 Oct; 46(4):496-501. PMID: 3051555.
    Citations:    Fields:    Translation:Animals
  153. Hoop B, Systrom DM, Shih VE, Kazemi H. Central respiratory effects of glutamine synthesis inhibition in dogs. J Appl Physiol (1985). 1988 Sep; 65(3):1099-109. PMID: 2903134.
    Citations:    Fields:    Translation:AnimalsCells
  154. Systrom DM, Vega J. Acute Asthma Algorithm. The standard reference in the MGH EW for diagnosing and treating acute asthma. Commissioned by MGH Emergency Dept. Utilized in ongoing multicenter trial. 1988.
  155. Salahi F, Systrom D, DiCola V, Boucher C, Hand R, Kanarek DJ, Harthorne J.W. Cardiopulmonary exercise testing in DDD compared to VVI pacing modes. AM J Noninvas Cardiol. 1987; 1:244-50.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.