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Dennis J. Selkoe, M.D.

Co-Author

This page shows the publications co-authored by Dennis Selkoe and Ulf Dettmer.
Connection Strength

5.135
  1. Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D. Loss of native a-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells. Hum Mol Genet. 2017 09 15; 26(18):3466-3481.
    View in: PubMed
    Score: 0.824
  2. Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Corrigendum: Parkinson-causing a-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun. 2015 Jul 30; 6:8008.
    View in: PubMed
    Score: 0.711
  3. Dettmer U, Newman AJ, von Saucken VE, Bartels T, Selkoe D. KTKEGV repeat motifs are key mediators of normal a-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity. Proc Natl Acad Sci U S A. 2015 Aug 04; 112(31):9596-601.
    View in: PubMed
    Score: 0.708
  4. Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Parkinson-causing a-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun. 2015 Jun 16; 6:7314.
    View in: PubMed
    Score: 0.705
  5. Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D. In vivo cross-linking reveals principally oligomeric forms of a-synuclein and ß-synuclein in neurons and non-neural cells. J Biol Chem. 2013 Mar 01; 288(9):6371-85.
    View in: PubMed
    Score: 0.596
  6. Fanning S, Selkoe D, Dettmer U. Parkinson's disease: proteinopathy or lipidopathy? NPJ Parkinsons Dis. 2020; 6:3.
    View in: PubMed
    Score: 0.242
  7. Imberdis T, Negri J, Ramalingam N, Terry-Kantor E, Ho GPH, Fanning S, Stirtz G, Kim TE, Levy OA, Young-Pearse TL, Selkoe D, Dettmer U. Cell models of lipid-rich a-synuclein aggregation validate known modifiers of a-synuclein biology and identify stearoyl-CoA desaturase. Proc Natl Acad Sci U S A. 2019 10 08; 116(41):20760-20769.
    View in: PubMed
    Score: 0.237
  8. Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D. Lipidomic Analysis of a-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell. 2019 03 07; 73(5):1001-1014.e8.
    View in: PubMed
    Score: 0.224
  9. Nuber S, Rajsombath M, Minakaki G, Winkler J, Müller CP, Ericsson M, Caldarone B, Dettmer U, Selkoe DJ. Abrogating Native a-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease. Neuron. 2018 10 10; 100(1):75-90.e5.
    View in: PubMed
    Score: 0.222
  10. Dettmer U, Selkoe D, Bartels T. New insights into cellular a-synuclein homeostasis in health and disease. Curr Opin Neurobiol. 2016 Feb; 36:15-22.
    View in: PubMed
    Score: 0.178
  11. Luth ES, Bartels T, Dettmer U, Kim NC, Selkoe DJ. Purification of a-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity. Biochemistry. 2015 Jan 20; 54(2):279-92.
    View in: PubMed
    Score: 0.171
  12. Newman AJ, Selkoe D, Dettmer U. A new method for quantitative immunoblotting of endogenous a-synuclein. PLoS One. 2013; 8(11):e81314.
    View in: PubMed
    Score: 0.158
  13. Selkoe D, Dettmer U, Luth E, Kim N, Newman A, Bartels T. Defining the native state of a-synuclein. Neurodegener Dis. 2014; 13(2-3):114-7.
    View in: PubMed
    Score: 0.158
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.