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Dennis J. Selkoe, M.D.

Title
Institution
Department
Address
Phone
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Mentoring
Cholesterol-Dependent Modulation of Gamma-Secretase In Vitro
Summer, 06/04/07 - 08/10/07
Biochemical characterization of amyloid-beta assemblies in the brains of patients with Alzheimer's disease
Summer, 05/26/08 - 08/15/08
DISC1 and Its Interaction with APP in a Neuronal Precursor Cell Migration Pathway
Summer, 06/22/09 - 08/14/09
Proteomic Profiling of the Alzheimer’s disease â-site APP Cleaving Enzyme (BACE)
Summer, 06/01/09 - 09/01/09

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21NS103123 (NUBER, SILKE) Aug 15, 2017 - Jul 31, 2019
    NIH/NINDS
    Shifting Multimers: New mouse and culture models of ?-synuclein truncation by calpain in PD
    Role: Co-Principal Investigator
  2. R01NS083845 (SELKOE, DENNIS J) Feb 1, 2014 - Jan 31, 2019
    NIH/NINDS
    Biology of Native Alpha-Synuclein Tetramers in Parkinson's Disease
    Role: Principal Investigator
  3. R01AG027443 (SELKOE, DENNIS J) Apr 1, 2006 - Mar 31, 2012
    NIH/NIA
    Pathogenic Mechanisms of Cell-Derived Abeta Oligomers
    Role: Principal Investigator
  4. R01NS051318 (SELKOE, DENNIS J) Jan 15, 2006 - Dec 31, 2011
    NIH/NINDS
    Alpha-Synuclein, PUFA and Membrane Vesicles in Health and Parkinson's Disease
    Role: Principal Investigator
  5. P01AG015379 (SELKOE, DENNIS J) Sep 30, 1998 - Jun 30, 2018
    NIH/NIA
    Presenilin Biology and the Mechanisms of Alzheimer's Disease
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Selkoe DJ. Light at the End of the Amyloid TunnelPublished as part of the Biochemistry series "Biochemistry to Bedside". Biochemistry. 2018 Oct 01. PMID: 30272957.
    View in: PubMed
  2. Xu H, Rajsombath MM, Weikop P, Selkoe DJ. Enriched environment enhances ß-adrenergic signaling to prevent microglia inflammation by amyloid-ß. EMBO Mol Med. 2018 Sep; 10(9). PMID: 30093491.
    View in: PubMed
  3. Zhao J, Li A, Rajsombath M, Dang Y, Selkoe DJ, Li S. Soluble Aß Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region. iScience. 2018 Aug 31; 6:138-150. PMID: 30240608.
    View in: PubMed
  4. Jin M, O'Nuallain B, Hong W, Boyd J, Lagomarsino VN, O'Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM. An in vitro paradigm to assess potential anti-Aß antibodies for Alzheimer's disease. Nat Commun. 2018 Jul 11; 9(1):2676. PMID: 29992960.
    View in: PubMed
  5. El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM. MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. Acta Neuropathol. 2018 Oct; 136(4):537-555. PMID: 29982852.
    View in: PubMed
  6. Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM. Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles. Int J Mol Sci. 2018 Feb 27; 19(3). PMID: 29495441.
    View in: PubMed
  7. Muratore CR, Zhou C, Liao M, Fernandez MA, Taylor WM, Lagomarsino VN, Pearse RV, Rice HC, Negri JM, He A, Srikanth P, Callahan DG, Shin T, Zhou M, Bennett DA, Noggle S, Love JC, Selkoe DJ, Young-Pearse TL. Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability. Stem Cell Reports. 2017 12 12; 9(6):1868-1884. PMID: 29153990.
    View in: PubMed
  8. Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D. Loss of native a-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells. Hum Mol Genet. 2017 09 15; 26(18):3466-3481. PMID: 28911198.
    View in: PubMed
  9. Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Schüle B, Park DS, Riise T, Scherzer CR. ß2-Adrenoreceptor is a regulator of the a-synuclein gene driving risk of Parkinson's disease. Science. 2017 09 01; 357(6354):891-898. PMID: 28860381.
    View in: PubMed
  10. Wang G, Li S, Gilbert J, Gritton HJ, Wang Z, Li Z, Han X, Selkoe DJ, Man HY. Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory. Cell Rep. 2017 08 08; 20(6):1335-1347. PMID: 28793258.
    View in: PubMed
  11. Mollenhauer B, Batrla R, El-Agnaf O, Galasko DR, Lashuel HA, Merchant KM, Shaw LM, Selkoe DJ, Umek R, Vanderstichele H, Zetterberg H, Zhang J, Caspell-Garcia C, Coffey C, Hutten SJ, Frasier M, Taylor P. A user's guide for a-synuclein biomarker studies in biological fluids: Perianalytical considerations. Mov Disord. 2017 Aug; 32(8):1117-1130. PMID: 28734051.
    View in: PubMed
  12. Selkoe DJ. Showing transmitters the door: synucleins accelerate vesicle release. Nat Neurosci. 2017 Apr 25; 20(5):629-631. PMID: 28440807.
    View in: PubMed
  13. Callahan DG, Taylor WM, Tilearcio M, Cavanaugh T, Selkoe DJ, Young-Pearse TL. Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex. Dev Biol. 2017 04 15; 424(2):138-146. PMID: 28284905.
    View in: PubMed
  14. Yang T, Li S, Xu H, Walsh DM, Selkoe DJ. Large Soluble Oligomers of Amyloid ß-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate. J Neurosci. 2017 01 04; 37(1):152-163. PMID: 28053038.
    View in: PubMed
  15. Bolduc DM, Selkoe DJ, Wolfe MS. Enzymatic Assays for Studying Intramembrane Proteolysis. Methods Enzymol. 2017; 584:295-308. PMID: 28065268.
    View in: PubMed
  16. Xu H, Gelyana E, Rajsombath M, Yang T, Li S, Selkoe D. Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid ß-Protein Oligomers. J Neurosci. 2016 08 31; 36(35):9041-56. PMID: 27581448.
    View in: PubMed
  17. Bolduc DM, Montagna DR, Seghers MC, Wolfe MS, Selkoe DJ. The amyloid-beta forming tripeptide cleavage mechanism of ?-secretase. Elife. 2016 08 31; 5. PMID: 27580372.
    View in: PubMed
  18. Nuber S, Selkoe DJ. Caspase-1 clipping causes complications for a-synuclein. Proc Natl Acad Sci U S A. 2016 Sep 06; 113(36):9958-60. PMID: 27551083; PMCID: PMC5018740 [Available on 03/06/17].
  19. Selkoe DJ, Hardy J. The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol Med. 2016 06; 8(6):595-608. PMID: 27025652.
    View in: PubMed
  20. Walsh DM, Selkoe DJ. A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration. Nat Rev Neurosci. 2016 Apr; 17(4):251-60. PMID: 26988744.
    View in: PubMed
  21. Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens B. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science. 2016 May 06; 352(6286):712-716. PMID: 27033548.
    View in: PubMed
  22. Zhang J, Lu D, Wei HX, Gu Y, Selkoe DJ, Wolfe MS, Augelli-Szafran CE. Part 3: Notch-sparing ?-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinones. Bioorg Med Chem Lett. 2016 May 01; 26(9):2138-41. PMID: 27038496.
    View in: PubMed
  23. Wei HX, Lu D, Sun V, Zhang J, Gu Y, Osenkowski P, Ye W, Selkoe DJ, Wolfe MS, Augelli-Szafran CE. Part 2. Notch-sparing ?-secretase inhibitors: The study of novel ?-amino naphthyl alcohols. Bioorg Med Chem Lett. 2016 May 01; 26(9):2133-7. PMID: 27020305.
    View in: PubMed
  24. Lu D, Wei HX, Zhang J, Gu Y, Osenkowski P, Ye W, Selkoe DJ, Wolfe MS, Augelli-Szafran CE. Part 1: Notch-sparing ?-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs. Bioorg Med Chem Lett. 2016 May 01; 26(9):2129-32. PMID: 27013392.
    View in: PubMed
  25. Selkoe DJ, Weinberger DR. Editorial overview: Neurobiology of disease. Curr Opin Neurobiol. 2016 Feb; 36:v-vii. PMID: 26797413.
    View in: PubMed
  26. Bolduc DM, Montagna DR, Gu Y, Selkoe DJ, Wolfe MS. Nicastrin functions to sterically hinder ?-secretase-substrate interactions driven by substrate transmembrane domain. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):E509-18. PMID: 26699478; PMCID: PMC4747693.
  27. Chen AC, Kim S, Shepardson N, Patel S, Hong S, Selkoe DJ. Physical and functional interaction between the a- and ?-secretases: A new model of regulated intramembrane proteolysis. J Cell Biol. 2015 Dec 21; 211(6):1157-76. PMID: 26694839; PMCID: PMC4687875.
  28. Leriche G, Chen AC, Kim S, Selkoe DJ, Yang J. Fluorescent Analogue of Batimastat Enables Imaging of a-Secretase in Living Cells. ACS Chem Neurosci. 2016 Jan 20; 7(1):40-5. PMID: 26559179; PMCID: PMC4720558 [Available on 01/20/17].
  29. Lei M, Xu H, Li Z, Wang Z, O'Malley TT, Zhang D, Walsh DM, Xu P, Selkoe DJ, Li S. Soluble Aß oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance. Neurobiol Dis. 2016 Jan; 85:111-121. PMID: 26525100; PMCID: PMC4778388 [Available on 01/01/17].
  30. Srikanth P, Han K, Callahan DG, Makovkina E, Muratore CR, Lalli MA, Zhou H, Boyd JD, Kosik KS, Selkoe DJ, Young-Pearse TL. Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate. Cell Rep. 2015 Sep 01; 12(9):1414-29. PMID: 26299970; PMCID: PMC4558300.
  31. Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, Selkoe DJ, Sperling RA, St George-Hyslop P, Tanzi RE, Yap L, Young AB, Phelps CH, McCaffrey PG. Massachusetts Alzheimer's Disease Research Center: progress and challenges. Alzheimers Dement. 2015 Oct; 11(10):1241-5. PMID: 26297855.
    View in: PubMed
  32. Dettmer U, Selkoe D, Bartels T. New insights into cellular a-synuclein homeostasis in health and disease. Curr Opin Neurobiol. 2016 Feb; 36:15-22. PMID: 26282834.
    View in: PubMed
  33. Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Corrigendum: Parkinson-causing a-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun. 2015 Jul 30; 6:8008. PMID: 26224447.
    View in: PubMed
  34. Kanmert D, Cantlon A, Muratore CR, Jin M, O'Malley TT, Lee G, Young-Pearse TL, Selkoe DJ, Walsh DM. C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death. J Neurosci. 2015 Jul 29; 35(30):10851-65. PMID: 26224867.
    View in: PubMed
  35. Locascio JJ, Eberly S, Liao Z, Liu G, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Dhima K, Hung AY, Flaherty AW, Schwarzschild MA, Hayes MT, Wills AM, Shivraj Sohur U, Mejia NI, Selkoe DJ, Oakes D, Shoulson I, Dong X, Marek K, Zheng B, Ivinson A, Hyman BT, Growdon JH, Sudarsky LR, Schlossmacher MG, Ravina B, Scherzer CR. Association between a-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease. Brain. 2015 Sep; 138(Pt 9):2659-71. PMID: 26220939; PMCID: PMC4643625.
  36. Dettmer U, Newman AJ, von Saucken VE, Bartels T, Selkoe D. KTKEGV repeat motifs are key mediators of normal a-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity. Proc Natl Acad Sci U S A. 2015 Aug 04; 112(31):9596-601. PMID: 26153422; PMCID: PMC4534262.
  37. Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Parkinson-causing a-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun. 2015 Jun 16; 6:7314. PMID: 26076669; PMCID: PMC4490410.
  38. Jin M, Selkoe DJ. Systematic analysis of time-dependent neural effects of soluble amyloid ß oligomers in culture and in vivo: Prevention by scyllo-inositol. Neurobiol Dis. 2015 Oct; 82:152-163. PMID: 26054438; PMCID: PMC4640956 [Available on 10/01/16].
  39. Yang T, O'Malley TT, Kanmert D, Jerecic J, Zieske LR, Zetterberg H, Hyman BT, Walsh DM, Selkoe DJ. A highly sensitive novel immunoassay specifically detects low levels of soluble Aß oligomers in human cerebrospinal fluid. Alzheimers Res Ther. 2015; 7(1):14. PMID: 25802556; PMCID: PMC4369838.
  40. Luth ES, Bartels T, Dettmer U, Kim NC, Selkoe DJ. Purification of a-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity. Biochemistry. 2015 Jan 20; 54(2):279-92. PMID: 25490121; PMCID: PMC4303315.
  41. Bartels T, Kim NC, Luth ES, Selkoe DJ. N-alpha-acetylation of a-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation. PLoS One. 2014; 9(7):e103727. PMID: 25075858; PMCID: PMC4116227.
  42. Renella R, Schlehe JS, Selkoe DJ, Williams DA, LaVoie MJ. Genetic deletion of the GATA1-regulated protein a-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes. Am J Hematol. 2014 Oct; 89(10):974-7. PMID: 25043722; PMCID: PMC4533827.
  43. Wolfe MS, Selkoe DJ. ?-Secretase: a horseshoe structure brings good luck. Cell. 2014 Jul 17; 158(2):247-249. PMID: 25036627.
    View in: PubMed
  44. Holmes O, Paturi S, Selkoe DJ, Wolfe MS. Pen-2 is essential for ?-secretase complex stability and trafficking but partially dispensable for endoproteolysis. Biochemistry. 2014 Jul 15; 53(27):4393-406. PMID: 24941111; PMCID: PMC4216188.
  45. Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ. Secreted amyloid ß-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity. Biochemistry. 2014 Jun 24; 53(24):3908-21. PMID: 24840308; PMCID: PMC4070750.
  46. Holmes O, Paturi S, Wolfe MS, Selkoe DJ. Functional analysis and purification of a Pen-2 fusion protein for ?-secretase structural studies. J Neurochem. 2014 Oct; 131(1):94-100. PMID: 24865334; PMCID: PMC4177330.
  47. Luth ES, Stavrovskaya IG, Bartels T, Kristal BS, Selkoe DJ. Soluble, prefibrillar a-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction. J Biol Chem. 2014 Aug 01; 289(31):21490-507. PMID: 24942732; PMCID: PMC4118111.
  48. Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, DeKosky ST, Gauthier S, Selkoe D, Bateman R, Cappa S, Crutch S, Engelborghs S, Frisoni GB, Fox NC, Galasko D, Habert MO, Jicha GA, Nordberg A, Pasquier F, Rabinovici G, Robert P, Rowe C, Salloway S, Sarazin M, Epelbaum S, de Souza LC, Vellas B, Visser PJ, Schneider L, Stern Y, Scheltens P, Cummings JL. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. Lancet Neurol. 2014 Jun; 13(6):614-29. PMID: 24849862.
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  49. Hong S, Ostaszewski BL, Yang T, O'Malley TT, Jin M, Yanagisawa K, Li S, Bartels T, Selkoe DJ. Soluble Aß oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes. Neuron. 2014 Apr 16; 82(2):308-19. PMID: 24685176; PMCID: PMC4129520.
  50. Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL. The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Hum Mol Genet. 2014 Jul 01; 23(13):3523-36. PMID: 24524897; PMCID: PMC4049307.
  51. Newman AJ, Selkoe D, Dettmer U. A new method for quantitative immunoblotting of endogenous a-synuclein. PLoS One. 2013; 8(11):e81314. PMID: 24278419; PMCID: PMC3835431.
  52. Selkoe D, Dettmer U, Luth E, Kim N, Newman A, Bartels T. Defining the native state of a-synuclein. Neurodegener Dis. 2014; 13(2-3):114-7. PMID: 24192542.
    View in: PubMed
  53. Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Hayes MT, Sohur US, Wills AM, Mollenhauer B, Flaherty AW, Hung AY, Mejia N, Khurana V, Gomperts SN, Selkoe DJ, Schwarzschild MA, Schlossmacher MG, Hyman BT, Sudarsky LR, Growdon JH, Scherzer CR. Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study. Neurology. 2013 Oct 22; 81(17):1531-7. PMID: 24068787; PMCID: PMC3888173.
  54. Selkoe DJ. The therapeutics of Alzheimer's disease: where we stand and where we are heading. Ann Neurol. 2013 Sep; 74(3):328-36. PMID: 25813842.
    View in: PubMed
  55. Selkoe DJ. SnapShot: pathobiology of Alzheimer's disease. Cell. 2013 Jul 18; 154(2):468-468.e1. PMID: 23870132.
    View in: PubMed
  56. Rice HC, Young-Pearse TL, Selkoe DJ. Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein. Biochemistry. 2013 May 14; 52(19):3264-77. PMID: 23597280; PMCID: PMC3809327.
  57. Koeglsperger T, Li S, Brenneis C, Saulnier JL, Mayo L, Carrier Y, Selkoe DJ, Weiner HL. Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-ß1 in the CNS. Glia. 2013 Jun; 61(6):985-1002. PMID: 23536313; PMCID: PMC3981075.
  58. Li S, Jin M, Zhang D, Yang T, Koeglsperger T, Fu H, Selkoe DJ. Environmental novelty activates ß2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aß oligomers. Neuron. 2013 Mar 06; 77(5):929-41. PMID: 23473322; PMCID: PMC3596823.
  59. Yang T, Hong S, O'Malley T, Sperling RA, Walsh DM, Selkoe DJ. New ELISAs with high specificity for soluble oligomers of amyloid ß-protein detect natural Aß oligomers in human brain but not CSF. Alzheimers Dement. 2013 Mar; 9(2):99-112. PMID: 23375565; PMCID: PMC3604133.
  60. Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D. In vivo cross-linking reveals principally oligomeric forms of a-synuclein and ß-synuclein in neurons and non-neural cells. J Biol Chem. 2013 Mar 01; 288(9):6371-85. PMID: 23319586; PMCID: PMC3585072.
  61. Holtzman DM, Mandelkow E, Selkoe DJ. Alzheimer disease in 2020. Cold Spring Harb Perspect Med. 2012 Nov 01; 2(11). PMID: 23125202; PMCID: PMC3543098.
  62. Selkoe DJ. Preventing Alzheimer's disease. Science. 2012 Sep 21; 337(6101):1488-92. PMID: 22997326.
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  63. Rice HC, Townsend M, Bai J, Suth S, Cavanaugh W, Selkoe DJ, Young-Pearse TL. Pancortins interact with amyloid precursor protein and modulate cortical cell migration. Development. 2012 Nov; 139(21):3986-96. PMID: 22992957; PMCID: PMC3472593.
  64. Findeis MA, Schroeder F, McKee TD, Yager D, Fraering PC, Creaser SP, Austin WF, Clardy J, Wang R, Selkoe D, Eckman CB. Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa. ACS Chem Neurosci. 2012 Nov 21; 3(11):941-51. PMID: 23205187; PMCID: PMC3509716.
  65. Koyama A, Okereke OI, Yang T, Blacker D, Selkoe DJ, Grodstein F. Plasma amyloid-ß as a predictor of dementia and cognitive decline: a systematic review and meta-analysis. Arch Neurol. 2012 Jul; 69(7):824-31. PMID: 22451159; PMCID: PMC3772635.
  66. Mucke L, Selkoe DJ. Neurotoxicity of amyloid ß-protein: synaptic and network dysfunction. Cold Spring Harb Perspect Med. 2012 Jul; 2(7):a006338. PMID: 22762015; PMCID: PMC3385944.
  67. Masters CL, Selkoe DJ. Biochemistry of amyloid ß-protein and amyloid deposits in Alzheimer disease. Cold Spring Harb Perspect Med. 2012 Jun; 2(6):a006262. PMID: 22675658; PMCID: PMC3367542.
  68. Holmes O, Paturi S, Ye W, Wolfe MS, Selkoe DJ. Effects of membrane lipids on the activity and processivity of purified ?-secretase. Biochemistry. 2012 May 01; 51(17):3565-75. PMID: 22489600; PMCID: PMC3347702.
  69. Villemagne VL, Klunk WE, Mathis CA, Rowe CC, Brooks DJ, Hyman BT, Ikonomovic MD, Ishii K, Jack CR, Jagust WJ, Johnson KA, Koeppe RA, Lowe VJ, Masters CL, Montine TJ, Morris JC, Nordberg A, Petersen RC, Reiman EM, Selkoe DJ, Sperling RA, Van Laere K, Weiner MW, Drzezga A. Aß Imaging: feasible, pertinent, and vital to progress in Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2012 Feb; 39(2):209-19. PMID: 22218879; PMCID: PMC3261395.
  70. Selkoe D, Mandelkow E, Holtzman D. Deciphering Alzheimer disease. Cold Spring Harb Perspect Med. 2012 Jan; 2(1):a011460. PMID: 22315723; PMCID: PMC3253026.
  71. Townsend MK, Okereke OI, Xia W, Yang T, Selkoe DJ, Grodstein F. Relation between insulin, insulin-related factors, and plasma amyloid beta peptide levels at midlife in a population-based study. Alzheimer Dis Assoc Disord. 2012 Jan-Mar; 26(1):50-4. PMID: 21502851; PMCID: PMC3140548.
  72. Morris JC, Selkoe DJ. Recommendations for the incorporation of biomarkers into Alzheimer clinical trials: an overview. Neurobiol Aging. 2011 Dec; 32 Suppl 1:S1-3. PMID: 22078168.
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  73. Wang X, Winter D, Ashrafi G, Schlehe J, Wong YL, Selkoe D, Rice S, Steen J, LaVoie MJ, Schwarz TL. PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell. 2011 Nov 11; 147(4):893-906. PMID: 22078885; PMCID: PMC3261796.
  74. Hong S, Quintero-Monzon O, Ostaszewski BL, Podlisny DR, Cavanaugh WT, Yang T, Holtzman DM, Cirrito JR, Selkoe DJ. Dynamic analysis of amyloid ß-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aß during age-related plaque formation. J Neurosci. 2011 Nov 02; 31(44):15861-9. PMID: 22049429; PMCID: PMC3227224.
  75. Shepardson NE, Shankar GM, Selkoe DJ. Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations. Arch Neurol. 2011 Nov; 68(11):1385-92. PMID: 22084122; PMCID: PMC3248784.
  76. Yakunin E, Loeb V, Kisos H, Biala Y, Yehuda S, Yaari Y, Selkoe DJ, Sharon R. ?-synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease. Brain Pathol. 2012 May; 22(3):280-94. PMID: 21929559; PMCID: PMC3253141.
  77. Shepardson NE, Shankar GM, Selkoe DJ. Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies. Arch Neurol. 2011 Oct; 68(10):1239-44. PMID: 21987540; PMCID: PMC3211071.
  78. Ding H, Sarokhan AK, Roderick SS, Bakshi R, Maher NE, Ashourian P, Kan CG, Chang S, Santarlasci A, Swords KE, Ravina BM, Hayes MT, Sohur US, Wills AM, Flaherty AW, Unni VK, Hung AY, Selkoe DJ, Schwarzschild MA, Schlossmacher MG, Sudarsky LR, Growdon JH, Ivinson AJ, Hyman BT, Scherzer CR. Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study. Mov Disord. 2011 Oct; 26(12):2283-6. PMID: 21953863; PMCID: PMC3337217.
  79. Selkoe DJ. Resolving controversies on the path to Alzheimer's therapeutics. Nat Med. 2011 Sep 07; 17(9):1060-5. PMID: 21900936.
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  80. Bartels T, Choi JG, Selkoe DJ. a-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature. 2011 Aug 14; 477(7362):107-10. PMID: 21841800; PMCID: PMC3166366.
  81. Selkoe DJ. Alzheimer's disease. Cold Spring Harb Perspect Biol. 2011 Jul 01; 3(7). PMID: 21576255; PMCID: PMC3119915.
  82. Li S, Jin M, Koeglsperger T, Shepardson NE, Shankar GM, Selkoe DJ. Soluble Aß oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. J Neurosci. 2011 May 04; 31(18):6627-38. PMID: 21543591; PMCID: PMC3100898.
  83. Okereke OI, Selkoe DJ, Grodstein F. Plasma beta-amyloid level, cognitive reserve, and cognitive decline. JAMA. 2011 Apr 27; 305(16):1655; author reply 1655-6. PMID: 21521843.
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  84. Meissner C, Lorenz H, Weihofen A, Selkoe DJ, Lemberg MK. The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking. J Neurochem. 2011 Jun; 117(5):856-67. PMID: 21426348.
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  85. Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci U S A. 2011 Apr 05; 108(14):5819-24. PMID: 21421841; PMCID: PMC3078381.
  86. Davis RC, Marsden IT, Maloney MT, Minamide LS, Podlisny M, Selkoe DJ, Bamburg JR. Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation. Mol Neurodegener. 2011 Jan 24; 6:10. PMID: 21261978; PMCID: PMC3037337.
  87. Shankar GM, Welzel AT, McDonald JM, Selkoe DJ, Walsh DM. Isolation of low-n amyloid ß-protein oligomers from cultured cells, CSF, and brain. Methods Mol Biol. 2011; 670:33-44. PMID: 20967581.
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  88. Young-Pearse TL, Suth S, Luth ES, Sawa A, Selkoe DJ. Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development. J Neurosci. 2010 Aug 04; 30(31):10431-40. PMID: 20685985; PMCID: PMC3018837.
  89. Wolfe MS, Selkoe DJ. Giving Alzheimer's the old one-two. Cell. 2010 Jul 23; 142(2):194-6. PMID: 20655461.
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  90. Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, Manolopoulou M, Tang WJ, Stein RL, Cuny GD, Selkoe DJ. Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. PLoS One. 2010 May 07; 5(5):e10504. PMID: 20498699.
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  91. Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DM. The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain. 2010 May; 133(Pt 5):1328-41. PMID: 20403962; PMCID: PMC2859152.
  92. Li S, Shankar GM, Selkoe DJ. How do Soluble Oligomers of Amyloid beta-protein Impair Hippocampal Synaptic Plasticity? Front Cell Neurosci. 2010; 4:5. PMID: 20428510; PMCID: PMC2859875.
  93. Sperling RA, Dickerson BC, Pihlajamaki M, Vannini P, LaViolette PS, Vitolo OV, Hedden T, Becker JA, Rentz DM, Selkoe DJ, Johnson KA. Functional alterations in memory networks in early Alzheimer's disease. Neuromolecular Med. 2010 Mar; 12(1):27-43. PMID: 20069392.
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  94. Sala Frigerio C, Fadeeva JV, Minogue AM, Citron M, Van Leuven F, Staufenbiel M, Paganetti P, Selkoe DJ, Walsh DM. beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins. FEBS J. 2010 Mar; 277(6):1503-18. PMID: 20163459; PMCID: PMC2847843.
  95. Chen AC, Guo LY, Ostaszewski BL, Selkoe DJ, LaVoie MJ. Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates. J Biol Chem. 2010 Apr 09; 285(15):11378-91. PMID: 20145246; PMCID: PMC2857016.
  96. Freir DB, Fedriani R, Scully D, Smith IM, Selkoe DJ, Walsh DM, Regan CM. Aß oligomers inhibit synapse remodelling necessary for memory consolidation. Neurobiol Aging. 2011 Dec; 32(12):2211-8. PMID: 20097446.
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  97. Espuny-Camacho I, Dominguez D, Merchiers P, Van Rompaey L, Selkoe D, De Strooper B. Peroxisome proliferator-activated receptor gamma enhances the activity of an insulin degrading enzyme-like metalloprotease for amyloid-beta clearance. J Alzheimers Dis. 2010; 20(4):1119-32. PMID: 20413872.
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  98. Hemming ML, Elias JE, Gygi SP, Selkoe DJ. Identification of beta-secretase (BACE1) substrates using quantitative proteomics. PLoS One. 2009 Dec 29; 4(12):e8477. PMID: 20041192.
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  99. Okereke OI, Xia W, Selkoe DJ, Grodstein F. Ten-year change in plasma amyloid beta levels and late-life cognitive decline. Arch Neurol. 2009 Oct; 66(10):1247-53. PMID: 19822780; PMCID: PMC2761951.
  100. Zota V, Nemirovsky A, Baron R, Fisher Y, Selkoe DJ, Altmann DM, Weiner HL, Monsonego A. HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele. J Immunol. 2009 Sep 01; 183(5):3522-30. PMID: 19675171.
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  101. Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DM. Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiol Dis. 2009 Nov; 36(2):293-302. PMID: 19660551; PMCID: PMC2782414.
  102. Sperling RA, Laviolette PS, O'Keefe K, O'Brien J, Rentz DM, Pihlajamaki M, Marshall G, Hyman BT, Selkoe DJ, Hedden T, Buckner RL, Becker JA, Johnson KA. Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron. 2009 Jul 30; 63(2):178-88. PMID: 19640477; PMCID: PMC2738994.
  103. Rappley I, Myers DS, Milne SB, Ivanova PT, Lavoie MJ, Brown HA, Selkoe DJ. Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with alpha-synuclein genotype. J Neurochem. 2009 Oct; 111(1):15-25. PMID: 19627450; PMCID: PMC2752313.
  104. Li S, Hong S, Shepardson NE, Walsh DM, Shankar GM, Selkoe D. Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron. 2009 Jun 25; 62(6):788-801. PMID: 19555648; PMCID: PMC2702854.
  105. Cabrol C, Huzarska MA, Dinolfo C, Rodriguez MC, Reinstatler L, Ni J, Yeh LA, Cuny GD, Stein RL, Selkoe DJ, Leissring MA. Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening. PLoS One. 2009; 4(4):e5274. PMID: 19384407; PMCID: PMC2668070.
  106. Li H, Wolfe MS, Selkoe DJ. Toward structural elucidation of the gamma-secretase complex. Structure. 2009 Mar 11; 17(3):326-34. PMID: 19278647; PMCID: PMC2661031.
  107. Weihofen A, Thomas KJ, Ostaszewski BL, Cookson MR, Selkoe DJ. Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking. Biochemistry. 2009 Mar 10; 48(9):2045-52. PMID: 19152501; PMCID: PMC2693257.
  108. Rappley I, Gitler AD, Selvy PE, LaVoie MJ, Levy BD, Brown HA, Lindquist S, Selkoe DJ. Evidence that alpha-synuclein does not inhibit phospholipase D. Biochemistry. 2009 Feb 10; 48(5):1077-83. PMID: 19146388; PMCID: PMC2683767.
  109. Xia W, Yang T, Shankar G, Smith IM, Shen Y, Walsh DM, Selkoe DJ. A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease. Arch Neurol. 2009 Feb; 66(2):190-9. PMID: 19204155; PMCID: PMC3618974.
  110. Okereke OI, Selkoe DJ, Pollak MN, Stampfer MJ, Hu FB, Hankinson SE, Grodstein F. A profile of impaired insulin degradation in relation to late-life cognitive decline: a preliminary investigation. Int J Geriatr Psychiatry. 2009 Feb; 24(2):177-82. PMID: 18612998; PMCID: PMC2631087.
  111. Minogue AM, Stubbs AK, Frigerio CS, Boland B, Fadeeva JV, Tang J, Selkoe DJ, Walsh DM. gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons. Brain Res. 2009 Mar 25; 1262:89-99. PMID: 19401174.
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  112. Okereke OI, Xia W, Irizarry MC, Sun X, Qiu WQ, Fagan AM, Mehta PD, Hyman BT, Selkoe DJ, Grodstein F. Performance characteristics of plasma amyloid-beta 40 and 42 assays. J Alzheimers Dis. 2009; 16(2):277-85. PMID: 19221417; PMCID: PMC2737811.
  113. Osenkowski P, Li H, Ye W, Li D, Aeschbach L, Fraering PC, Wolfe MS, Selkoe DJ, Li H. Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution. J Mol Biol. 2009 Jan 16; 385(2):642-52. PMID: 19013469; PMCID: PMC2830092.
  114. Ben Gedalya T, Loeb V, Israeli E, Altschuler Y, Selkoe DJ, Sharon R. Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling. Traffic. 2009 Feb; 10(2):218-34. PMID: 18980610; PMCID: PMC2694501.
  115. Hemming ML, Elias JE, Gygi SP, Selkoe DJ. Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements. PLoS Biol. 2008 Oct 21; 6(10):e257. PMID: 18942891.
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  116. Neant-Fery M, Garcia-Ordoñez RD, Logan TP, Selkoe DJ, Li L, Reinstatler L, Leissring MA. Molecular basis for the thiol sensitivity of insulin-degrading enzyme. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9582-7. PMID: 18621727; PMCID: PMC2474492.
  117. Young-Pearse TL, Chen AC, Chang R, Marquez C, Selkoe DJ. Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. Neural Dev. 2008 Jun 23; 3:15. PMID: 18573216; PMCID: PMC2442059.
  118. Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008 Aug; 14(8):837-42. PMID: 18568035; PMCID: PMC2772133.
  119. Betts V, Leissring MA, Dolios G, Wang R, Selkoe DJ, Walsh DM. Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin. Neurobiol Dis. 2008 Sep; 31(3):442-50. PMID: 18602473; PMCID: PMC3160758.
  120. Osenkowski P, Ye W, Wang R, Wolfe MS, Selkoe DJ. Direct and potent regulation of gamma-secretase by its lipid microenvironment. J Biol Chem. 2008 Aug 15; 283(33):22529-40. PMID: 18539594; PMCID: PMC2504869.
  121. Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ. Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization. J Neurosci. 2008 Apr 16; 28(16):4231-7. PMID: 18417702; PMCID: PMC2685151.
  122. Selkoe DJ. Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behav Brain Res. 2008 Sep 01; 192(1):106-13. PMID: 18359102; PMCID: PMC2601528.
  123. Okereke OI, Pollak MN, Hu FB, Hankinson SE, Selkoe DJ, Grodstein F. Plasma C-peptide levels and rates of cognitive decline in older, community-dwelling women without diabetes. Psychoneuroendocrinology. 2008 May; 33(4):455-61. PMID: 18261857; PMCID: PMC2396343.
  124. Nazer B, Hong S, Selkoe DJ. LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model. Neurobiol Dis. 2008 Apr; 30(1):94-102. PMID: 18289866; PMCID: PMC2376120.
  125. Selkoe DJ. Biochemistry and molecular biology of amyloid beta-protein and the mechanism of Alzheimer's disease. Handb Clin Neurol. 2008; 89:245-60. PMID: 18631749.
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  126. Young-Pearse TL, Bai J, Chang R, Zheng JB, LoTurco JJ, Selkoe DJ. A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference. J Neurosci. 2007 Dec 26; 27(52):14459-69. PMID: 18160654.
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  127. Selkoe DJ. Developing preventive therapies for chronic diseases: lessons learned from Alzheimer's disease. Nutr Rev. 2007 Dec; 65(12 Pt 2):S239-43. PMID: 18240556.
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  128. Assayag K, Yakunin E, Loeb V, Selkoe DJ, Sharon R. Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cells. Am J Pathol. 2007 Dec; 171(6):2000-11. PMID: 18055555; PMCID: PMC2111122.
  129. Weihofen A, Ostaszewski B, Minami Y, Selkoe DJ. Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1. Hum Mol Genet. 2008 Feb 15; 17(4):602-16. PMID: 18003639.
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  130. Cacquevel M, Aeschbach L, Osenkowski P, Li D, Ye W, Wolfe MS, Li H, Selkoe DJ, Fraering PC. Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease. J Neurochem. 2008 Jan; 104(1):210-20. PMID: 17986218.
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  131. Selkoe DJ, Wolfe MS. Presenilin: running with scissors in the membrane. Cell. 2007 Oct 19; 131(2):215-21. PMID: 17956719.
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  132. Townsend M, Mehta T, Selkoe DJ. Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem. 2007 Nov 16; 282(46):33305-12. PMID: 17855343.
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  133. Hemming ML, Patterson M, Reske-Nielsen C, Lin L, Isacson O, Selkoe DJ. Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease. PLoS Med. 2007 Aug; 4(8):e262. PMID: 17760499; PMCID: PMC1952204.
  134. Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ. Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. Am J Pathol. 2007 Jul; 171(1):241-51. PMID: 17591969; PMCID: PMC1941603.
  135. Qiu WQ, Sun X, Selkoe DJ, Mwamburi DM, Huang T, Bhadela R, Bergethon P, Scott TM, Summergrad P, Wang L, Rosenberg I, Folstein M. Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly. Int J Geriatr Psychiatry. 2007 Jun; 22(6):536-42. PMID: 17096467.
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  136. Walsh DM, Minogue AM, Sala Frigerio C, Fadeeva JV, Wasco W, Selkoe DJ. The APP family of proteins: similarities and differences. Biochem Soc Trans. 2007 Apr; 35(Pt 2):416-20. PMID: 17371289.
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  137. Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci. 2007 Mar 14; 27(11):2866-75. PMID: 17360908.
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  138. Chen AC, Selkoe DJ. Response to: Pardossi-Piquard et al., "Presenilin-Dependent Transcriptional Control of the Abeta-Degrading Enzyme Neprilysin by Intracellular Domains of betaAPP and APLP." Neuron 46, 541-554. Neuron. 2007 Feb 15; 53(4):479-83. PMID: 17296549.
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  139. Walsh DM, Selkoe DJ. A beta oligomers - a decade of discovery. J Neurochem. 2007 Jun; 101(5):1172-84. PMID: 17286590.
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  140. Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol. 2007 Feb; 8(2):101-12. PMID: 17245412.
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  141. Hemming ML, Selkoe DJ, Farris W. Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease. Neurobiol Dis. 2007 Apr; 26(1):273-81. PMID: 17321748; PMCID: PMC2377010.
  142. Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE. Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families. J Biol Chem. 2007 Mar 16; 282(11):7825-32. PMID: 17244626.
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  143. Townsend M, Cleary JP, Mehta T, Hofmeister J, Lesne S, O'Hare E, Walsh DM, Selkoe DJ. Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers. Ann Neurol. 2006 Dec; 60(6):668-76. PMID: 17192927.
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  144. Leissring MA, Selkoe DJ. Structural biology: enzyme target to latch on to. Nature. 2006 Oct 19; 443(7113):761-2. PMID: 17051198.
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  145. Celone KA, Calhoun VD, Dickerson BC, Atri A, Chua EF, Miller SL, DePeau K, Rentz DM, Selkoe DJ, Blacker D, Albert MS, Sperling RA. Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis. J Neurosci. 2006 Oct 04; 26(40):10222-31. PMID: 17021177.
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  146. Selkoe DJ. The ups and downs of Abeta. Nat Med. 2006 Jul; 12(7):758-9; discussion 759. PMID: 16829932.
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  147. Lazarov VK, Fraering PC, Ye W, Wolfe MS, Selkoe DJ, Li H. Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores. Proc Natl Acad Sci U S A. 2006 May 02; 103(18):6889-94. PMID: 16636269; PMCID: PMC1458989.
  148. Réchards M, Xia W, Oorschot V, van Dijk S, Annaert W, Selkoe DJ, Klumperman J. Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments. Traffic. 2006 Mar; 7(3):354-64. PMID: 16497228.
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  149. Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ. Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. J Physiol. 2006 Apr 15; 572(Pt 2):477-92. PMID: 16469784; PMCID: PMC1779683.
  150. Selkoe DJ. Amyloid beta-peptide is produced by cultured cells during normal metabolism: a reprise. J Alzheimers Dis. 2006; 9(3 Suppl):163-8. PMID: 16914855.
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  151. Whalen BM, Selkoe DJ, Hartley DM. Small non-fibrillar assemblies of amyloid beta-protein bearing the Arctic mutation induce rapid neuritic degeneration. Neurobiol Dis. 2005 Nov; 20(2):254-66. PMID: 16242634.
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  152. Walsh DM, Klyubin I, Shankar GM, Townsend M, Fadeeva JV, Betts V, Podlisny MB, Cleary JP, Ashe KH, Rowan MJ, Selkoe DJ. The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention. Biochem Soc Trans. 2005 Nov; 33(Pt 5):1087-90. PMID: 16246051.
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  153. Fraering PC, Ye W, LaVoie MJ, Ostaszewski BL, Selkoe DJ, Wolfe MS. gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site. J Biol Chem. 2005 Dec 23; 280(51):41987-96. PMID: 16236717; PMCID: PMC1523323.
  154. LaVoie MJ, Ostaszewski BL, Weihofen A, Schlossmacher MG, Selkoe DJ. Dopamine covalently modifies and functionally inactivates parkin. Nat Med. 2005 Nov; 11(11):1214-21. PMID: 16227987.
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  155. Selkoe DJ. By the way, doctor. Is there a brain scan that can specifically diagnose Alzheimer's disease? Harv Health Lett. 2005 Oct; 30(12):8. PMID: 16278983.
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  156. Hemming ML, Selkoe DJ. Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor. J Biol Chem. 2005 Nov 11; 280(45):37644-50. PMID: 16154999; PMCID: PMC2409196.
  157. Kimberly WT, Zheng JB, Town T, Flavell RA, Selkoe DJ. Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation. J Neurosci. 2005 Jun 08; 25(23):5533-43. PMID: 15944381.
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  158. Farris W, Leissring MA, Hemming ML, Chang AY, Selkoe DJ. Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein. Biochemistry. 2005 May 03; 44(17):6513-25. PMID: 15850385.
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  159. Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med. 2005 May; 11(5):556-61. PMID: 15834427.
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  160. Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, El Agnaf O, Hartley DM, Selkoe DJ. Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation. J Neurosci. 2005 Mar 09; 25(10):2455-62. PMID: 15758153.
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  161. Selkoe DJ. Defining molecular targets to prevent Alzheimer disease. Arch Neurol. 2005 Feb; 62(2):192-5. PMID: 15710846.
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  162. Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci. 2005 Jan; 8(1):79-84. PMID: 15608634.
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  163. Chyung JH, Raper DM, Selkoe DJ. Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage. J Biol Chem. 2005 Feb 11; 280(6):4383-92. PMID: 15569674.
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  164. Leissring MA, Farris W, Wu X, Christodoulou DC, Haigis MC, Guarente L, Selkoe DJ. Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria. Biochem J. 2004 Nov 01; 383(Pt. 3):439-46. PMID: 15285718; PMCID: PMC1133736.
  165. Selkoe DJ. Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases. Nat Cell Biol. 2004 Nov; 6(11):1054-61. PMID: 15516999.
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  166. Walsh DM, Selkoe DJ. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron. 2004 Sep 30; 44(1):181-93. PMID: 15450169.
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  167. Ye C, Walsh DM, Selkoe DJ, Hartley DM. Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation. Neurosci Lett. 2004 Aug 19; 366(3):320-5. PMID: 15288443.
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  168. Fraering PC, Ye W, Strub JM, Dolios G, LaVoie MJ, Ostaszewski BL, van Dorsselaer A, Wang R, Selkoe DJ, Wolfe MS. Purification and characterization of the human gamma-secretase complex. Biochemistry. 2004 Aug 03; 43(30):9774-89. PMID: 15274632.
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  169. Lemere CA, Beierschmitt A, Iglesias M, Spooner ET, Bloom JK, Leverone JF, Zheng JB, Seabrook TJ, Louard D, Li D, Selkoe DJ, Palmour RM, Ervin FR. Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet. Am J Pathol. 2004 Jul; 165(1):283-97. PMID: 15215183; PMCID: PMC1618542.
  170. Walsh DM, Selkoe DJ. Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration. Protein Pept Lett. 2004 Jun; 11(3):213-28. PMID: 15182223.
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  171. Hayashi H, Kimura N, Yamaguchi H, Hasegawa K, Yokoseki T, Shibata M, Yamamoto N, Michikawa M, Yoshikawa Y, Terao K, Matsuzaki K, Lemere CA, Selkoe DJ, Naiki H, Yanagisawa K. A seed for Alzheimer amyloid in the brain. J Neurosci. 2004 May 19; 24(20):4894-902. PMID: 15152051.
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  172. Klyubin I, Walsh DM, Cullen WK, Fadeeva JV, Anwyl R, Selkoe DJ, Rowan MJ. Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo. Eur J Neurosci. 2004 May; 19(10):2839-46. PMID: 15147317.
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  173. Selkoe DJ. Alzheimer disease: mechanistic understanding predicts novel therapies. Ann Intern Med. 2004 Apr 20; 140(8):627-38. PMID: 15096334.
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  174. Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. Am J Pathol. 2004 Apr; 164(4):1425-34. PMID: 15039230; PMCID: PMC1615329.
  175. Wang Q, Walsh DM, Rowan MJ, Selkoe DJ, Anwyl R. Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. J Neurosci. 2004 Mar 31; 24(13):3370-8. PMID: 15056716.
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  176. Fraering PC, LaVoie MJ, Ye W, Ostaszewski BL, Kimberly WT, Selkoe DJ, Wolfe MS. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex. Biochemistry. 2004 Jan 20; 43(2):323-33. PMID: 14717586.
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  177. Selkoe DJ. Folding proteins in fatal ways. Nature. 2003 Dec 18; 426(6968):900-4. PMID: 14685251.
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  178. Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP, Selkoe DJ. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron. 2003 Dec 18; 40(6):1087-93. PMID: 14687544.
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  179. Baulac S, LaVoie MJ, Kimberly WT, Strahle J, Wolfe MS, Selkoe DJ, Xia W. Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates. Neurobiol Dis. 2003 Nov; 14(2):194-204. PMID: 14572442.
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  180. Selkoe DJ. Aging, amyloid, and Alzheimer's disease: a perspective in honor of Carl Cotman. Neurochem Res. 2003 Nov; 28(11):1705-13. PMID: 14584824.
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  181. Chyung JH, Selkoe DJ. Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface. J Biol Chem. 2003 Dec 19; 278(51):51035-43. PMID: 14525989.
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  182. Lemere CA, Spooner ET, LaFrancois J, Malester B, Mori C, Leverone JF, Matsuoka Y, Taylor JW, DeMattos RB, Holtzman DM, Clements JD, Selkoe DJ, Duff KE. Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice. Neurobiol Dis. 2003 Oct; 14(1):10-8. PMID: 13678662.
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  183. Sharon R, Bar-Joseph I, Mirick GE, Serhan CN, Selkoe DJ. Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies. J Biol Chem. 2003 Dec 12; 278(50):49874-81. PMID: 14507911.
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  184. Réchards M, Xia W, Oorschot VM, Selkoe DJ, Klumperman J. Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes. Traffic. 2003 Aug; 4(8):553-65. PMID: 12839498.
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  185. Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL. Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. J Clin Invest. 2003 Aug; 112(3):415-22. PMID: 12897209; PMCID: PMC166296.
  186. Ye CP, Selkoe DJ, Hartley DM. Protofibrils of amyloid beta-protein inhibit specific K+ currents in neocortical cultures. Neurobiol Dis. 2003 Aug; 13(3):177-90. PMID: 12901832.
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  187. Leissring MA, Lu A, Condron MM, Teplow DB, Stein RL, Farris W, Selkoe DJ. Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays. J Biol Chem. 2003 Sep 26; 278(39):37314-20. PMID: 12867419.
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  188. LaVoie MJ, Fraering PC, Ostaszewski BL, Ye W, Kimberly WT, Wolfe MS, Selkoe DJ. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin. J Biol Chem. 2003 Sep 26; 278(39):37213-22. PMID: 12857757.
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  189. LaVoie MJ, Selkoe DJ. The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments. J Biol Chem. 2003 Sep 05; 278(36):34427-37. PMID: 12826675.
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  190. Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry. 2003 Jun 10; 42(22):6664-73. PMID: 12779321.
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  191. Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6382-7. PMID: 12740439; PMCID: PMC164455.
  192. Selkoe D, Kopan R. Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annu Rev Neurosci. 2003; 26:565-97. PMID: 12730322.
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  193. Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4162-7. PMID: 12634421; PMCID: PMC153065.
  194. Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ. The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron. 2003 Feb 20; 37(4):583-95. PMID: 12597857.
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  195. Kimberly WT, Esler WP, Ye W, Ostaszewski BL, Gao J, Diehl T, Selkoe DJ, Wolfe MS. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s). Biochemistry. 2003 Jan 14; 42(1):137-44. PMID: 12515548.
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  196. Selkoe DJ. Toward a remembrance of things past: deciphering Alzheimer disease. Harvey Lect. 2003-2004; 99:23-45. PMID: 15984550.
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  197. Weiner HL, Selkoe DJ. Inflammation and therapeutic vaccination in CNS diseases. Nature. 2002 Dec 19-26; 420(6917):879-84. PMID: 12490962.
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  198. Selkoe DJ. Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease. J Clin Invest. 2002 Nov; 110(10):1375-81. PMID: 12438432; PMCID: PMC151820.
  199. Selkoe DJ. Alzheimer's disease is a synaptic failure. Science. 2002 Oct 25; 298(5594):789-91. PMID: 12399581.
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  200. Craft DL, Wein LM, Selkoe DJ. A mathematical model of the impact of novel treatments on the A beta burden in the Alzheimer's brain, CSF and plasma. Bull Math Biol. 2002 Sep; 64(5):1011-31. PMID: 12391865.
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  201. Selkoe D. Alzheimer's disease: Conversation with an expert. Harv Health Lett. 2002 Sep; 27(11):5. PMID: 12356562.
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  202. Walsh DM, Klyubin I, Fadeeva JV, Rowan MJ, Selkoe DJ. Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochem Soc Trans. 2002 Aug; 30(4):552-7. PMID: 12196135.
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  203. Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002 Jul 19; 297(5580):353-6. PMID: 12130773.
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  204. Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation. J Biol Chem. 2002 Sep 20; 277(38):35113-7. PMID: 12130643.
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  205. Wolfe MS, Selkoe DJ. Biochemistry. Intramembrane proteases--mixing oil and water. Science. 2002 Jun 21; 296(5576):2156-7. PMID: 12077393.
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  206. Mori C, Spooner ET, Wisniewsk KE, Wisniewski TM, Yamaguch H, Saido TC, Tolan DR, Selkoe DJ, Lemere CA. Intraneuronal Abeta42 accumulation in Down syndrome brain. Amyloid. 2002 Jun; 9(2):88-102. PMID: 12440481.
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  207. Esler WP, Das C, Campbell WA, Kimberly WT, Kornilova AY, Diehl TS, Ye W, Ostaszewski BL, Xia W, Selkoe DJ, Wolfe MS. Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase. Nat Cell Biol. 2002 May; 4(5):E110-1; author reply E111-2. PMID: 11988746.
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  208. Schlossmacher MG, Frosch MP, Gai WP, Medina M, Sharma N, Forno L, Ochiishi T, Shimura H, Sharon R, Hattori N, Langston JW, Mizuno Y, Hyman BT, Selkoe DJ, Kosik KS. Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol. 2002 May; 160(5):1655-67. PMID: 12000718; PMCID: PMC1850875.
  209. Selkoe DJ, Podlisny MB. Deciphering the genetic basis of Alzheimer's disease. Annu Rev Genomics Hum Genet. 2002; 3:67-99. PMID: 12142353.
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  210. Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature. 2002 Apr 04; 416(6880):535-9. PMID: 11932745.
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  211. Esler WP, Kimberly WT, Ostaszewski BL, Ye W, Diehl TS, Selkoe DJ, Wolfe MS. Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2720-5. PMID: 11867728; PMCID: PMC122414.
  212. Zhang J, Ye W, Wang R, Wolfe MS, Greenberg BD, Selkoe DJ. Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides. J Biol Chem. 2002 Apr 26; 277(17):15069-75. PMID: 11839734.
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  213. Selkoe DJ, Schenk D. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annu Rev Pharmacol Toxicol. 2003; 43:545-84. PMID: 12415125.
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  214. Wang H, Wolosker H, Morris JF, Pevsner J, Snyder SH, Selkoe DJ. Naturally occurring free D-aspartate is a nuclear component of cells in the mammalian hypothalamo-neurohypophyseal system. Neuroscience. 2002; 109(1):1-4. PMID: 11784695.
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  215. Selkoe DJ. Introducing transglutaminase into the study of Alzheimer's disease. A personal look back. Neurochem Int. 2002 Jan; 40(1):13-6. PMID: 11738468.
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  216. Lemere CA, Maron R, Selkoe DJ, Weiner HL. Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer's disease. DNA Cell Biol. 2001 Nov; 20(11):705-11. PMID: 11788048.
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  217. Selkoe DJ. Clearing the brain's amyloid cobwebs. Neuron. 2001 Oct 25; 32(2):177-80. PMID: 11683988.
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  218. Selkoe DJ. Presenilin, Notch, and the genesis and treatment of Alzheimer's disease. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11039-41. PMID: 11572965; PMCID: PMC58679.
  219. Kimberly WT, Zheng JB, Guénette SY, Selkoe DJ. The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J Biol Chem. 2001 Oct 26; 276(43):40288-92. PMID: 11544248.
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  220. Monsonego A, Maron R, Zota V, Selkoe DJ, Weiner HL. Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10273-8. PMID: 11517335; PMCID: PMC56951.
  221. Sharon R, Goldberg MS, Bar-Josef I, Betensky RA, Shen J, Selkoe DJ. alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins. Proc Natl Acad Sci U S A. 2001 Jul 31; 98(16):9110-5. PMID: 11481478; PMCID: PMC55381.
  222. Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ. Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science. 2001 Jul 13; 293(5528):263-9. PMID: 11431533.
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  223. Walsh DM, Hartley DM, Condron MM, Selkoe DJ, Teplow DB. In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease. Biochem J. 2001 May 01; 355(Pt 3):869-77. PMID: 11311152; PMCID: PMC1221805.
  224. Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr; 81(2):741-66. PMID: 11274343.
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  225. Selkoe DJ. Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein. J Alzheimers Dis. 2001 Feb; 3(1):75-80. PMID: 12214075.
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  226. Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, Yhu S, McInnis MG, Go RC, Vekrellis K, Selkoe DJ, Saunders AJ, Tanzi RE. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science. 2000 Dec 22; 290(5500):2302-3. PMID: 11125142.
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  227. Fezoui Y, Hartley DM, Walsh DM, Selkoe DJ, Osterhout JJ, Teplow DB. A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils. Nat Struct Biol. 2000 Dec; 7(12):1095-9. PMID: 11101888.
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  228. Xia W, Ostaszewski BL, Kimberly WT, Rahmati T, Moore CL, Wolfe MS, Selkoe DJ. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex. Neurobiol Dis. 2000 Dec; 7(6 Pt B):673-81. PMID: 11114265.
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  229. Selkoe DJ. The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins. Neurol Clin. 2000 Nov; 18(4):903-22. PMID: 11072267.
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  230. Wang H, Wolosker H, Pevsner J, Snyder SH, Selkoe DJ. Regulation of rat magnocellular neurosecretory system by D-aspartate: evidence for biological role(s) of a naturally occurring free D-amino acid in mammals. J Endocrinol. 2000 Nov; 167(2):247-52. PMID: 11054638.
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  231. Chesneau V, Vekrellis K, Rosner MR, Selkoe DJ. Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization. Biochem J. 2000 Oct 15; 351 Pt 2:509-16. PMID: 11023838; PMCID: PMC1221388.
  232. Weiner HL, Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Issazadeh S, Hancock WW, Selkoe DJ. Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease. Ann Neurol. 2000 Oct; 48(4):567-79. PMID: 11026440.
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  233. Moore CL, Leatherwood DD, Diehl TS, Selkoe DJ, Wolfe MS. Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design. J Med Chem. 2000 Sep 07; 43(18):3434-42. PMID: 10978191.
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  234. Walsh DM, Tseng BP, Rydel RE, Podlisny MB, Selkoe DJ. The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry. 2000 Sep 05; 39(35):10831-9. PMID: 10978169.
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  235. Fezoui Y, Hartley DM, Harper JD, Khurana R, Walsh DM, Condron MM, Selkoe DJ, Lansbury PT, Fink AL, Teplow DB. An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments. Amyloid. 2000 Sep; 7(3):166-78. PMID: 11019857.
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  236. Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling. J Neurochem. 2000 Aug; 75(2):583-93. PMID: 10899933.
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  237. Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe MS, Zhang J, Goate AM, Selkoe DJ. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation. Proc Natl Acad Sci U S A. 2000 Aug 01; 97(16):9299-304. PMID: 10922078; PMCID: PMC16862.
  238. Selkoe DJ. Imaging Alzheimer's amyloid. Nat Biotechnol. 2000 Aug; 18(8):823-4. PMID: 10932146.
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  239. Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. Nat Cell Biol. 2000 Jul; 2(7):428-34. PMID: 10878808.
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  240. Selkoe DJ, Wolfe MS. In search of gamma-secretase: presenilin at the cutting edge. Proc Natl Acad Sci U S A. 2000 May 23; 97(11):5690-2. PMID: 10823929; PMCID: PMC33989.
  241. Selkoe DJ. The origins of Alzheimer disease: a is for amyloid. JAMA. 2000 Mar 22-29; 283(12):1615-7. PMID: 10735401.
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  242. Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J Neurosci. 2000 Mar 01; 20(5):1657-65. PMID: 10684867.
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  243. Kimberly WT, Xia W, Rahmati T, Wolfe MS, Selkoe DJ. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation. J Biol Chem. 2000 Feb 04; 275(5):3173-8. PMID: 10652302.
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  244. Selkoe DJ. Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration. Curr Opin Neurobiol. 2000 Feb; 10(1):50-7. PMID: 10679435.
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  245. Stoltzner SE, Grenfell TJ, Mori C, Wisniewski KE, Wisniewski TM, Selkoe DJ, Lemere CA. Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease. Am J Pathol. 2000 Feb; 156(2):489-99. PMID: 10666378; PMCID: PMC1850044.
  246. Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Desai R, Hancock WW, Weiner HL, Selkoe DJ. Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice. Ann N Y Acad Sci. 2000; 920:328-31. PMID: 11193172.
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  247. Selkoe DJ. Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein. Ann N Y Acad Sci. 2000; 924:17-25. PMID: 11193794.
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  248. Moore CL, Diehl TS, Selkoe DJ, Wolfe MS. Toward the characterization and identification of gamma-secretases using transition-state analogue inhibitors. Ann N Y Acad Sci. 2000; 920:197-205. PMID: 11193150.
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  249. Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Weinmaster G, Selkoe DJ, Hyman BT. Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity. Ann N Y Acad Sci. 2000; 920:223-6. PMID: 11193154.
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  250. Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM. Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch. J Biol Chem. 1999 Dec 17; 274(51):36801-7. PMID: 10593990.
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  251. Hartley DM, Walsh DM, Ye CP, Diehl T, Vasquez S, Vassilev PM, Teplow DB, Selkoe DJ. Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J Neurosci. 1999 Oct 15; 19(20):8876-84. PMID: 10516307.
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  252. Walsh DM, Hartley DM, Kusumoto Y, Fezoui Y, Condron MM, Lomakin A, Benedek GB, Selkoe DJ, Teplow DB. Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. J Biol Chem. 1999 Sep 03; 274(36):25945-52. PMID: 10464339.
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  253. Wolfe MS, De Los Angeles J, Miller DD, Xia W, Selkoe DJ. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease. Biochemistry. 1999 Aug 31; 38(35):11223-30. PMID: 10471271.
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  254. Perez RG, Soriano S, Hayes JD, Ostaszewski B, Xia W, Selkoe DJ, Chen X, Stokin GB, Koo EH. Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. J Biol Chem. 1999 Jul 02; 274(27):18851-6. PMID: 10383380.
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  255. Lemere CA, Grenfell TJ, Selkoe DJ. The AMY antigen co-occurs with abeta and follows its deposition in the amyloid plaques of Alzheimer's disease and down syndrome. Am J Pathol. 1999 Jul; 155(1):29-37. PMID: 10393833; PMCID: PMC1866646.
  256. Selkoe DJ. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature. 1999 Jun 24; 399(6738 Suppl):A23-31. PMID: 10392577.
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  257. Watson DJ, Selkoe DJ, Teplow DB. Effects of the amyloid precursor protein Glu693-->Gln 'Dutch' mutation on the production and stability of amyloid beta-protein. Biochem J. 1999 Jun 15; 340 ( Pt 3):703-9. PMID: 10359654; PMCID: PMC1220301.
  258. Poduslo JF, Curran GL, Sanyal B, Selkoe DJ. Receptor-mediated transport of human amyloid beta-protein 1-40 and 1-42 at the blood-brain barrier. Neurobiol Dis. 1999 Jun; 6(3):190-9. PMID: 10408808.
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  259. Querfurth HW, Jiang J, Xia W, Selkoe DJ. Enhancer function and novel DNA binding protein activity in the near upstream betaAPP gene promoter. Gene. 1999 May 17; 232(1):125-41. PMID: 10333529.
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  260. Wolfe MS, Xia W, Moore CL, Leatherwood DD, Ostaszewski B, Rahmati T, Donkor IO, Selkoe DJ. Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry. 1999 Apr 13; 38(15):4720-7. PMID: 10200159.
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  261. Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature. 1999 Apr 08; 398(6727):513-7. PMID: 10206644.
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  262. Westermark P, Araki S, Benson MD, Cohen AS, Frangione B, Masters CL, Saraiva MJ, Sipe JD, Husby G, Kyle RA, Selkoe D. Nomenclature of amyloid fibril proteins. Report from the meeting of the International Nomenclature Committee on Amyloidosis, August 8-9, 1998. Part 1. Amyloid. 1999 Mar; 6(1):63-6. PMID: 10211413.
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  263. Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem. 1998 Dec 04; 273(49):32730-8. PMID: 9830016.
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  264. Steiner H, Capell A, Pesold B, Citron M, Kloetzel PM, Selkoe DJ, Romig H, Mendla K, Haass C. Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation. J Biol Chem. 1998 Nov 27; 273(48):32322-31. PMID: 9822712.
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  265. Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi. Biochemistry. 1998 Nov 24; 37(47):16465-71. PMID: 9843412.
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  266. Selkoe DJ. The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol. 1998 Nov; 8(11):447-53. PMID: 9854312.
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  267. Citron M, Eckman CB, Diehl TS, Corcoran C, Ostaszewski BL, Xia W, Levesque G, St George Hyslop P, Younkin SG, Selkoe DJ. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein. Neurobiol Dis. 1998 Aug; 5(2):107-16. PMID: 9746908.
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  268. Xia MQ, Berezovska O, Kim TW, Xia WM, Liao A, Tanzi RE, Selkoe D, Hyman BT. Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease. J Neurol Sci. 1998 Jun 11; 158(1):15-23. PMID: 9667772.
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  269. Zhang J, Kang DE, Xia W, Okochi M, Mori H, Selkoe DJ, Koo EH. Subcellular distribution and turnover of presenilins in transfected cells. J Biol Chem. 1998 May 15; 273(20):12436-42. PMID: 9575200.
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  270. Podlisny MB, Walsh DM, Amarante P, Ostaszewski BL, Stimson ER, Maggio JE, Teplow DB, Selkoe DJ. Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red. Biochemistry. 1998 Mar 17; 37(11):3602-11. PMID: 9521679.
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  271. Capell A, Grünberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. J Biol Chem. 1998 Feb 06; 273(6):3205-11. PMID: 9452432.
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  272. Haass C, Selkoe DJ. Alzheimer's disease. A technical KO of amyloid-beta peptide. Nature. 1998 Jan 22; 391(6665):339-40. PMID: 9450743.
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  273. Wolfe MS, Citron M, Diehl TS, Xia W, Donkor IO, Selkoe DJ. A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity. J Med Chem. 1998 Jan 01; 41(1):6-9. PMID: 9438016.
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  274. Watson DJ, Lander AD, Selkoe DJ. Heparin-binding properties of the amyloidogenic peptides Abeta and amylin. Dependence on aggregation state and inhibition by Congo red. J Biol Chem. 1997 Dec 12; 272(50):31617-24. PMID: 9395501.
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  275. Querfurth HW, Jiang J, Geiger JD, Selkoe DJ. Caffeine stimulates amyloid beta-peptide release from beta-amyloid precursor protein-transfected HEK293 cells. J Neurochem. 1997 Oct; 69(4):1580-91. PMID: 9326287.
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  276. Selkoe DJ. Images in neuroscience. Alzheimer's disease: from genes to pathogenesis. Am J Psychiatry. 1997 Sep; 154(9):1198. PMID: 9286176.
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  277. Xia W, Zhang J, Perez R, Koo EH, Selkoe DJ. Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):8208-13. PMID: 9223340; PMCID: PMC21582.
  278. Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. Skeletal and CNS defects in Presenilin-1-deficient mice. Cell. 1997 May 16; 89(4):629-39. PMID: 9160754.
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  279. Walter J, Grünberg J, Capell A, Pesold B, Schindzielorz A, Citron M, Mendla K, George-Hyslop PS, Multhaup G, Selkoe DJ, Haass C. Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C. Proc Natl Acad Sci U S A. 1997 May 13; 94(10):5349-54. PMID: 9144240; PMCID: PMC24681.
  280. Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ. Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. J Biol Chem. 1997 Mar 21; 272(12):7977-82. PMID: 9065468.
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  281. Qiu WQ, Ye Z, Kholodenko D, Seubert P, Selkoe DJ. Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells. J Biol Chem. 1997 Mar 07; 272(10):6641-6. PMID: 9045694.
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  282. Yamazaki T, Koo EH, Selkoe DJ. Cell surface amyloid beta-protein precursor colocalizes with beta 1 integrins at substrate contact sites in neural cells. J Neurosci. 1997 Feb 01; 17(3):1004-10. PMID: 8994055.
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  283. Selkoe DJ. Alzheimer's disease: genotypes, phenotypes, and treatments. Science. 1997 Jan 31; 275(5300):630-1. PMID: 9019820.
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  284. Walter J, Capell A, Hung AY, Langen H, Schnölzer M, Thinakaran G, Sisodia SS, Selkoe DJ, Haass C. Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations. J Biol Chem. 1997 Jan 17; 272(3):1896-903. PMID: 8999878.
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  285. Poduslo JF, Curran GL, Haggard JJ, Biere AL, Selkoe DJ. Permeability and residual plasma volume of human, Dutch variant, and rat amyloid beta-protein 1-40 at the blood-brain barrier. Neurobiol Dis. 1997; 4(1):27-34. PMID: 9258909.
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  286. Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, Strome R, Lieberburg I, Rommens J, Kim S, Schenk D, Fraser P, St George Hyslop P, Selkoe DJ. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nat Med. 1997 Jan; 3(1):67-72. PMID: 8986743.
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  287. Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue. Neurobiol Dis. 1997; 3(4):325-37. PMID: 9173929.
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  288. Lalowski M, Golabek A, Lemere CA, Selkoe DJ, Wisniewski HM, Beavis RC, Frangione B, Wisniewski T. The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid. J Biol Chem. 1996 Dec 27; 271(52):33623-31. PMID: 8969231.
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  289. Biere AL, Ostaszewski B, Stimson ER, Hyman BT, Maggio JE, Selkoe DJ. Amyloid beta-peptide is transported on lipoproteins and albumin in human plasma. J Biol Chem. 1996 Dec 20; 271(51):32916-22. PMID: 8955133.
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  290. Citron M, Diehl TS, Gordon G, Biere AL, Seubert P, Selkoe DJ. Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):13170-5. PMID: 8917563; PMCID: PMC24065.
  291. Doan A, Thinakaran G, Borchelt DR, Slunt HH, Ratovitsky T, Podlisny M, Selkoe DJ, Seeger M, Gandy SE, Price DL, Sisodia SS. Protein topology of presenilin 1. Neuron. 1996 Nov; 17(5):1023-30. PMID: 8938133.
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  292. Walter J, Capell A, Grünberg J, Pesold B, Schindzielorz A, Prior R, Podlisny MB, Fraser P, Hyslop PS, Selkoe DJ, Haass C. The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Mol Med. 1996 Nov; 2(6):673-91. PMID: 8972483.
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  293. Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi H, Ruiz A, Martinez A, Madrigal L, Hincapie L, Arango JC, Anthony DC, Koo EH, Goate AM, Selkoe DJ, Arango JC. The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology. Nat Med. 1996 Oct; 2(10):1146-50. PMID: 8837617.
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  294. Calingasan NY, Gandy SE, Baker H, Sheu KF, Smith JD, Lamb BT, Gearhart JD, Buxbaum JD, Harper C, Selkoe DJ, Price DL, Sisodia SS, Gibson GE. Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency. Am J Pathol. 1996 Sep; 149(3):1063-71. PMID: 8780408; PMCID: PMC1865137.
  295. Selkoe DJ. Amyloid beta-protein and the genetics of Alzheimer's disease. J Biol Chem. 1996 Aug 02; 271(31):18295-8. PMID: 8756120.
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  296. Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med. 1996 Aug; 2(8):864-70. PMID: 8705854.
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  297. Citron M, Diehl TS, Capell A, Haass C, Teplow DB, Selkoe DJ. Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF. Neuron. 1996 Jul; 17(1):171-9. PMID: 8755488.
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  298. Cummings BJ, Satou T, Head E, Milgram NW, Cole GM, Savage MJ, Podlisny MB, Selkoe DJ, Siman R, Greenberg BD, Cotman CW. Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs. Neurobiol Aging. 1996 Jul-Aug; 17(4):653-9. PMID: 8832640.
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  299. Tamaoka A, Endoh R, Shoji S, Takahashi H, Hirokawa K, Teplow DB, Selkoe DJ, Mori H. Antibodies to amyloid beta protein (A beta) crossreact with glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Neurobiol Aging. 1996 May-Jun; 17(3):405-14. PMID: 8725902.
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  300. Koo EH, Squazzo SL, Selkoe DJ, Koo CH. Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody. J Cell Sci. 1996 May; 109 ( Pt 5):991-8. PMID: 8743946.
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  301. Yamazaki T, Koo EH, Selkoe DJ. Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization. J Cell Sci. 1996 May; 109 ( Pt 5):999-1008. PMID: 8743947.
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  302. Qiu WQ, Borth W, Ye Z, Haass C, Teplow DB, Selkoe DJ. Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex. J Biol Chem. 1996 Apr 05; 271(14):8443-51. PMID: 8626544.
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  303. Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ. Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiol Dis. 1996 Feb; 3(1):16-32. PMID: 9173910.
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  304. Stephenson DT, Lemere CA, Selkoe DJ, Clemens JA. Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain. Neurobiol Dis. 1996 Feb; 3(1):51-63. PMID: 9173912.
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  305. Selkoe DJ, Yamazaki T, Citron M, Podlisny MB, Koo EH, Teplow DB, Haass C. The role of APP processing and trafficking pathways in the formation of amyloid beta-protein. Ann N Y Acad Sci. 1996 Jan 17; 777:57-64. PMID: 8624127.
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  306. Selkoe DJ. Cell biology of the beta-amyloid precursor protein and the genetics of Alzheimer's disease. Cold Spring Harb Symp Quant Biol. 1996; 61:587-96. PMID: 9246485.
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  307. Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nat Med. 1995 Dec; 1(12):1291-6. PMID: 7489411.
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  308. Munger JS, Haass C, Lemere CA, Shi GP, Wong WS, Teplow DB, Selkoe DJ, Chapman HA. Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S. Biochem J. 1995 Oct 01; 311 ( Pt 1):299-305. PMID: 7575468; PMCID: PMC1136152.
  309. Selkoe DJ. Alzheimer's amyloid of another flavour. Nat Med. 1995 Oct; 1(10):998-9. PMID: 7489384.
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  310. Greenberg SM, Qiu WQ, Selkoe DJ, Ben-Itzhak A, Kosik KS. Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase. Neurosci Lett. 1995 Sep 22; 198(1):52-6. PMID: 8570096.
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  311. Selkoe DJ. Alzheimer's disease. Missense on the membrane. Nature. 1995 Jun 29; 375(6534):734-5. PMID: 7596402.
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  312. Biere AL, Ostaszewski B, Zhao H, Gillespie S, Younkin SG, Selkoe DJ. Co-expression of beta-amyloid precursor protein (betaAPP) and apolipoprotein E in cell culture: analysis of betaAPP processing. Neurobiol Dis. 1995 Jun; 2(3):177-87. PMID: 9174001.
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  313. Podlisny MB, Ostaszewski BL, Squazzo SL, Koo EH, Rydell RE, Teplow DB, Selkoe DJ. Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture. J Biol Chem. 1995 Apr 21; 270(16):9564-70. PMID: 7721886.
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  314. Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, Selkoe DJ. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. Am J Pathol. 1995 Apr; 146(4):848-60. PMID: 7717452; PMCID: PMC1869262.
  315. Yamazaki T, Selkoe DJ, Koo EH. Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons. J Cell Biol. 1995 Apr; 129(2):431-42. PMID: 7721945; PMCID: PMC2199904.
  316. Haass C, Capell A, Citron M, Teplow DB, Selkoe DJ. The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein. J Biol Chem. 1995 Mar 17; 270(11):6186-92. PMID: 7890753.
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  317. Qiu WQ, Ferreira A, Miller C, Koo EH, Selkoe DJ. Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. J Neurosci. 1995 Mar; 15(3 Pt 2):2157-67. PMID: 7891158.
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  318. Haas C, Hung AY, Citron M, Teplow DB, Selkoe DJ. beta-Amyloid, protein processing and Alzheimer's disease. Arzneimittelforschung. 1995 Mar; 45(3A):398-402. PMID: 7763333.
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  319. Citron M, Teplow DB, Selkoe DJ. Generation of amyloid beta protein from its precursor is sequence specific. Neuron. 1995 Mar; 14(3):661-70. PMID: 7695913.
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  320. Querfurth HW, Wijsman EM, St George-Hyslop PH, Selkoe DJ. Beta APP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family. Brain Res Mol Brain Res. 1995 Feb; 28(2):319-37. PMID: 7723630.
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  321. Haass C, Koo EH, Capell A, Teplow DB, Selkoe DJ. Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals. J Cell Biol. 1995 Feb; 128(4):537-47. PMID: 7860629; PMCID: PMC2199885.
  322. Citron M, Vigo-Pelfrey C, Teplow DB, Miller C, Schenk D, Johnston J, Winblad B, Venizelos N, Lannfelt L, Selkoe DJ. Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation. Proc Natl Acad Sci U S A. 1994 Dec 06; 91(25):11993-7. PMID: 7991571; PMCID: PMC45362.
  323. Selkoe DJ. Amyloid beta-protein precursor: new clues to the genesis of Alzheimer's disease. Curr Opin Neurobiol. 1994 Oct; 4(5):708-16. PMID: 7849528.
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  324. Selkoe DJ. Alzheimer's disease: a central role for amyloid. J Neuropathol Exp Neurol. 1994 Sep; 53(5):438-47. PMID: 8083687.
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  325. Greenberg SM, Koo EH, Selkoe DJ, Qiu WQ, Kosik KS. Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7104-8. PMID: 8041753; PMCID: PMC44347.
  326. Haass C, Hung AY, Selkoe DJ, Teplow DB. Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor. J Biol Chem. 1994 Jul 01; 269(26):17741-8. PMID: 8021287.
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  327. Querfurth HW, Selkoe DJ. Calcium ionophore increases amyloid beta peptide production by cultured cells. Biochemistry. 1994 Apr 19; 33(15):4550-61. PMID: 8161510.
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  328. Bons N, Mestre N, Ritchie K, Petter A, Podlisny M, Selkoe D. Identification of amyloid beta protein in the brain of the small, short-lived lemurian primate Microcebus murinus. Neurobiol Aging. 1994 Mar-Apr; 15(2):215-20. PMID: 7838294.
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  329. Haass C, Koo EH, Teplow DB, Selkoe DJ. Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells. Proc Natl Acad Sci U S A. 1994 Feb 15; 91(4):1564-8. PMID: 8108445; PMCID: PMC43200.
  330. Hung AY, Selkoe DJ. Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein. EMBO J. 1994 Feb 01; 13(3):534-42. PMID: 8313898; PMCID: PMC394842.
  331. Askanas V, Engel WK, Bilak M, Alvarez RB, Selkoe DJ. Twisted tubulofilaments of inclusion body myositis muscle resemble paired helical filaments of Alzheimer brain and contain hyperphosphorylated tau. Am J Pathol. 1994 Jan; 144(1):177-87. PMID: 8291607; PMCID: PMC1887131.
  332. Selkoe DJ. Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. Annu Rev Cell Biol. 1994; 10:373-403. PMID: 7888181.
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  333. Selkoe DJ. Alzheimer's disease beyond 1994: the path to therapeutics. Neurobiol Aging. 1994; 15 Suppl 2:S131-3. PMID: 7700437.
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  334. Maness LM, Banks WA, Podlisny MB, Selkoe DJ, Kastin AJ. Passage of human amyloid beta-protein 1-40 across the murine blood-brain barrier. Life Sci. 1994; 55(21):1643-50. PMID: 7968239.
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  335. Selkoe DJ. Normal and abnormal biology of the beta-amyloid precursor protein. Annu Rev Neurosci. 1994; 17:489-517. PMID: 8210185.
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  336. Haass C, Selkoe DJ. Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell. 1993 Dec 17; 75(6):1039-42. PMID: 8261505.
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  337. Hung AY, Haass C, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DJ. Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. J Biol Chem. 1993 Nov 05; 268(31):22959-62. PMID: 8226807.
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  338. Citron M, Haass C, Selkoe DJ. Production of amyloid-beta-peptide by cultured cells: no evidence for internal initiation of translation at Met596. Neurobiol Aging. 1993 Nov-Dec; 14(6):571-3. PMID: 8295660.
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  339. Selkoe DJ. Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease. Trends Neurosci. 1993 Oct; 16(10):403-9. PMID: 7504355.
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  340. Haass C, Hung AY, Schlossmacher MG, Oltersdorf T, Teplow DB, Selkoe DJ. Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules. Ann N Y Acad Sci. 1993 Sep 24; 695:109-16. PMID: 8239267.
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  341. Koo EH, Park L, Selkoe DJ. Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4748-52. PMID: 8506329; PMCID: PMC46590.
  342. Hanley MR, Selkoe DJ. Alzheimer's disease. Amyloid precursor on the G(o) Nature. 1993 Mar 04; 362(6415):14-5. PMID: 8383293.
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  343. Haass C, Hung AY, Schlossmacher MG, Teplow DB, Selkoe DJ. beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms. J Biol Chem. 1993 Feb 15; 268(5):3021-4. PMID: 8428976.
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  344. Podlisny MB, Stephenson DT, Frosch MP, Tolan DR, Lieberburg I, Clemens JA, Selkoe DJ. Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity. Am J Pathol. 1993 Jan; 142(1):17-24. PMID: 8424453; PMCID: PMC1886844.
  345. Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature. 1992 Dec 17; 360(6405):672-4. PMID: 1465129.
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  346. Fraser PE, Nguyen JT, Inouye H, Surewicz WK, Selkoe DJ, Podlisny MB, Kirschner DA. Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein. Biochemistry. 1992 Nov 10; 31(44):10716-23. PMID: 1420187.
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  347. Hung AY, Koo EH, Haass C, Selkoe DJ. Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage. Proc Natl Acad Sci U S A. 1992 Oct 15; 89(20):9439-43. PMID: 1409654; PMCID: PMC50147.
  348. Selkoe DJ. Aging brain, aging mind. Sci Am. 1992 Sep; 267(3):134-42. PMID: 1502515.
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  349. Podlisny MB, Stephenson DT, Frosch MP, Lieberburg I, Clemens JA, Selkoe DJ. Synthetic amyloid beta-protein fails to produce specific neurotoxicity in monkey cerebral cortex. Neurobiol Aging. 1992 Sep-Oct; 13(5):561-7. PMID: 1281288.
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  350. Mori H, Takio K, Ogawara M, Selkoe DJ. Mass spectrometry of purified amyloid beta protein in Alzheimer's disease. J Biol Chem. 1992 Aug 25; 267(24):17082-6. PMID: 1512246.
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  351. Yamaguchi H, Yamazaki T, Lemere CA, Frosch MP, Selkoe DJ. Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study. Am J Pathol. 1992 Jul; 141(1):249-59. PMID: 1632466; PMCID: PMC1886563.
  352. Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature. 1992 Jun 11; 357(6378):500-3. PMID: 1608449.
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  353. Schlossmacher MG, Ostaszewski BL, Hecker LI, Celi A, Haass C, Chin D, Lieberburg I, Furie BC, Furie B, Selkoe DJ. Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes. Neurobiol Aging. 1992 May-Jun; 13(3):421-34. PMID: 1625772.
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  354. Tamaoka A, Kalaria RN, Lieberburg I, Selkoe DJ. Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels. Proc Natl Acad Sci U S A. 1992 Feb 15; 89(4):1345-9. PMID: 1531538; PMCID: PMC48446.
  355. Golde TE, Estus S, Younkin LH, Selkoe DJ, Younkin SG. Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science. 1992 Feb 07; 255(5045):728-30. PMID: 1738847.
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  356. Joachim CL, Selkoe DJ. The seminal role of beta-amyloid in the pathogenesis of Alzheimer disease. Alzheimer Dis Assoc Disord. 1992; 6(1):7-34. PMID: 1605946.
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  357. Selkoe DJ. Alzheimer's disease. In the beginning... Nature. 1991 Dec 12; 354(6353):432-3. PMID: 1684220.
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  358. Haass C, Hung AY, Selkoe DJ. Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion. J Neurosci. 1991 Dec; 11(12):3783-93. PMID: 1744690.
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  359. Selkoe DJ. Amyloid protein and Alzheimer's disease. Sci Am. 1991 Nov; 265(5):68-71, 74-6, 78. PMID: 1785042.
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  360. Podlisny MB, Tolan DR, Selkoe DJ. Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease. Am J Pathol. 1991 Jun; 138(6):1423-35. PMID: 1905108; PMCID: PMC1886384.
  361. Selkoe DJ. The molecular pathology of Alzheimer's disease. Neuron. 1991 Apr; 6(4):487-98. PMID: 1673054.
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  362. Joachim C, Games D, Morris J, Ward P, Frenkel D, Selkoe D. Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques. Am J Pathol. 1991 Feb; 138(2):373-84. PMID: 1704190; PMCID: PMC1886178.
  363. Bodmer S, Podlisny MB, Selkoe DJ, Heid I, Fontana A. Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease. Biochem Biophys Res Commun. 1990 Sep 14; 171(2):890-7. PMID: 2119582.
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  364. Selkoe DJ. Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues. Science. 1990 Jun 01; 248(4959):1058-60. PMID: 2111582.
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  365. Mori H, Selkoe DJ. [Biochemistry of Alzheimer's disease]. Tanpakushitsu Kakusan Koso. 1990 May; 35(7 Suppl):1353-61. PMID: 2162553.
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  366. Podlisny MB, Mammen AL, Schlossmacher MG, Palmert MR, Younkin SG, Selkoe DJ. Detection of soluble forms of the beta-amyloid precursor protein in human plasma. Biochem Biophys Res Commun. 1990 Mar 30; 167(3):1094-101. PMID: 2138892.
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  367. Selkoe DJ, Podlisny MB, Gronbeck A, Mammen A, Kosik KS. Molecular relation of amyloid filaments and paired helical filaments in Alzheimer's disease. Adv Neurol. 1990; 51:171-9. PMID: 2104686.
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  368. Palmert MR, Siedlak SL, Podlisny MB, Greenberg B, Shelton ER, Chan HW, Usiak M, Selkoe DJ, Perry G, Younkin SG. Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein. Biochem Biophys Res Commun. 1989 Nov 30; 165(1):182-8. PMID: 2480122.
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  369. Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe D. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J Neuroimmunol. 1989 Oct; 24(3):173-82. PMID: 2808689.
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  370. Joachim CL, Mori H, Selkoe DJ. Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease. Nature. 1989 Sep 21; 341(6239):226-30. PMID: 2528696.
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  371. Selkoe DJ. Molecular pathology of amyloidogenic proteins and the role of vascular amyloidosis in Alzheimer's disease. Neurobiol Aging. 1989 Sep-Oct; 10(5):387-95. PMID: 2510035.
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  372. Selkoe DJ. Amyloid beta protein precursor and the pathogenesis of Alzheimer's disease. Cell. 1989 Aug 25; 58(4):611-2. PMID: 2504495.
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  373. Joachim CL, Morris JH, Selkoe DJ. Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. Am J Pathol. 1989 Aug; 135(2):309-19. PMID: 2675616; PMCID: PMC1879919.
  374. Palmert MR, Podlisny MB, Witker DS, Oltersdorf T, Younkin LH, Selkoe DJ, Younkin SG. The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid. Proc Natl Acad Sci U S A. 1989 Aug; 86(16):6338-42. PMID: 2503832; PMCID: PMC297834.
  375. Joachim CL, Selkoe DJ. Amyloid protein in Alzheimer's disease. J Gerontol. 1989 Jul; 44(4):B77-82. PMID: 2661641.
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  376. Selkoe DJ. Aging, amyloid, and Alzheimer's disease. N Engl J Med. 1989 Jun 01; 320(22):1484-7. PMID: 2654637.
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  377. Whitson JS, Selkoe DJ, Cotman CW. Amyloid beta protein enhances the survival of hippocampal neurons in vitro. Science. 1989 Mar 17; 243(4897):1488-90. PMID: 2928783.
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  378. Forno LS, Eng LF, Selkoe DJ. Pick bodies in the locus ceruleus. Acta Neuropathol. 1989; 79(1):10-7. PMID: 2555998.
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  379. Abraham CR, Selkoe DJ, Potter H, Price DL, Cork LC. Alpha 1-antichymotrypsin is present together with the beta-protein in monkey brain amyloid deposits. Neuroscience. 1989; 32(3):715-20. PMID: 2689908.
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  380. Selkoe DJ. The deposition of amyloid proteins in the aging mammalian brain: implications for Alzheimer's disease. Ann Med. 1989; 21(2):73-6. PMID: 2504258.
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  381. Selkoe DJ. Biochemistry of altered brain proteins in Alzheimer's disease. Annu Rev Neurosci. 1989; 12:463-90. PMID: 2648956.
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  382. Joachim CL, Duffy LK, Morris JH, Selkoe DJ. Protein chemical and immunocytochemical studies of meningovascular beta-amyloid protein in Alzheimer's disease and normal aging. Brain Res. 1988 Nov 22; 474(1):100-11. PMID: 3214703.
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  383. Cork LC, Powers RE, Selkoe DJ, Davies P, Geyer JJ, Price DL. Neurofibrillary tangles and senile plaques in aged bears. J Neuropathol Exp Neurol. 1988 Nov; 47(6):629-41. PMID: 3171607.
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  384. Palmert MR, Podlisny MB, Witker DS, Oltersdorf T, Younkin LH, Selkoe DJ, Younkin SG. Antisera to an amino-terminal peptide detect the amyloid protein precursor of Alzheimer's disease and recognize senile plaques. Biochem Biophys Res Commun. 1988 Oct 14; 156(1):432-7. PMID: 3140814.
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  385. Selkoe DJ, Podlisny MB, Joachim CL, Vickers EA, Lee G, Fritz LC, Oltersdorf T. Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. Proc Natl Acad Sci U S A. 1988 Oct; 85(19):7341-5. PMID: 3140239; PMCID: PMC282182.
  386. Joachim CL, Morris JH, Selkoe DJ. Clinically diagnosed Alzheimer's disease: autopsy results in 150 cases. Ann Neurol. 1988 Jul; 24(1):50-6. PMID: 3415200.
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  387. Nukina N, Kosik KS, Selkoe DJ. The monoclonal antibody, Alz 50, recognizes tau proteins in Alzheimer's disease brain. Neurosci Lett. 1988 May 03; 87(3):240-6. PMID: 3132653.
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  388. Abraham CR, Selkoe DJ, Potter H. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell. 1988 Feb 26; 52(4):487-501. PMID: 3257719.
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  389. Munoz DG, Greene C, Perl DP, Selkoe DJ. Accumulation of phosphorylated neurofilaments in anterior horn motoneurons of amyotrophic lateral sclerosis patients. J Neuropathol Exp Neurol. 1988 Jan; 47(1):9-18. PMID: 3334727.
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  390. Joachim CL, Morris JH, Selkoe DJ, Kosik KS. Tau epitopes are incorporated into a range of lesions in Alzheimer's disease. J Neuropathol Exp Neurol. 1987 Nov; 46(6):611-22. PMID: 2443617.
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  391. Podlisny MB, Lee G, Selkoe DJ. Gene dosage of the amyloid beta precursor protein in Alzheimer's disease. Science. 1987 Oct 30; 238(4827):669-71. PMID: 2960019.
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  392. Kirschner DA, Inouye H, Duffy LK, Sinclair A, Lind M, Selkoe DJ. Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro. Proc Natl Acad Sci U S A. 1987 Oct; 84(19):6953-7. PMID: 3477820; PMCID: PMC299203.
  393. Joachim CL, Morris JH, Kosik KS, Selkoe DJ. Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders. Ann Neurol. 1987 Oct; 22(4):514-20. PMID: 2963585.
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  394. Eidelberg D, Sotrel A, Joachim C, Selkoe D, Forman A, Pendlebury WW, Perl DP. Adult onset Hallervorden-Spatz disease with neurofibrillary pathology. A discrete clinicopathological entity. Brain. 1987 Aug; 110 ( Pt 4):993-1013. PMID: 2888513.
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  395. Nukina N, Kosik KS, Selkoe DJ. Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein. Proc Natl Acad Sci U S A. 1987 May; 84(10):3415-9. PMID: 3106969; PMCID: PMC304881.
  396. Selkoe DJ, Bell DS, Podlisny MB, Price DL, Cork LC. Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease. Science. 1987 Feb 20; 235(4791):873-7. PMID: 3544219.
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  397. Selkoe DJ. Altered structural proteins in plaques and tangles: what do they tell us about the biology of Alzheimer's disease? Neurobiol Aging. 1986 Nov-Dec; 7(6):425-32. PMID: 3104810.
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  398. Neve RL, Selkoe DJ, Kurnit DM, Kosik KS. A cDNA for a human microtubule associated protein 2 epitope in the Alzheimer neurofibrillary tangle. Brain Res. 1986 Nov; 387(2):193-6. PMID: 2431745.
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  399. Rasool CG, Svendsen CN, Selkoe DJ. Neurofibrillary degeneration of cholinergic and noncholinergic neurons of the basal forebrain in Alzheimer's disease. Ann Neurol. 1986 Oct; 20(4):482-8. PMID: 3539000.
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  400. Kosik KS, Joachim CL, Selkoe DJ. Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc Natl Acad Sci U S A. 1986 Jun; 83(11):4044-8. PMID: 2424016; PMCID: PMC323662.
  401. Selkoe DJ, Abraham CR, Podlisny MB, Duffy LK. Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease. J Neurochem. 1986 Jun; 46(6):1820-34. PMID: 3517233.
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  402. Perry G, Selkoe DJ, Block BR, Stewart D, Autilio-Gambetti L, Gambetti P. Electron microscopic localization of Alzheimer neurofibrillary tangle components recognized by an antiserum to paired helical filaments. J Neuropathol Exp Neurol. 1986 Mar; 45(2):161-8. PMID: 2419516.
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  403. Kirschner DA, Abraham C, Selkoe DJ. X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation. Proc Natl Acad Sci U S A. 1986 Jan; 83(2):503-7. PMID: 3455785; PMCID: PMC322888.
  404. Kosik KS, Bakalis SF, Selkoe DJ, Pierce MW, Duffy LK. High molecular weight microtubule-associated proteins: purification by electro-elution and amino acid compositions. J Neurosci Res. 1986; 15(4):543-51. PMID: 2873254.
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  405. Selkoe DJ, Abraham CR. Isolation of paired helical filaments and amyloid fibers from human brain. Methods Enzymol. 1986; 134:388-404. PMID: 3821571.
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  406. Kosik KS, Bakalis S, Galibert L, Selkoe DJ, Duffy LK. Age-related modifications of MAP-2. Ann N Y Acad Sci. 1986; 466:420-2. PMID: 2873778.
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  407. Rasool CG, Selkoe DJ. Sharing of specific antigens by degenerating neurons in Pick's disease and Alzheimer's disease. N Engl J Med. 1985 Mar 14; 312(11):700-5. PMID: 2579334.
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  408. Selkoe DJ, Abraham C, Rasool CG, McCluskey A, Kosik KS, Duffy LK. Paired helical filaments in human neurons: relationship to neurofilaments. Ann N Y Acad Sci. 1985; 455:583-96. PMID: 3936387.
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  409. Kosik KS, McCluskey AH, Walsh FX, Selkoe DJ. Axonal transport of cytoskeletal proteins in aluminum toxicity. Aluminum toxicity and axonal transport. Neurochem Pathol. 1985; 3(2):99-108. PMID: 2413406.
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  410. Kosik KS, Duffy LK, Dowling MM, Abraham C, McCluskey A, Selkoe DJ. Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles. Proc Natl Acad Sci U S A. 1984 Dec; 81(24):7941-5. PMID: 6083566; PMCID: PMC392269.
  411. Rasool CG, Selkoe DJ. Alzheimer's disease: exposure of neurofilament immunoreactivity in SDS-insoluble paired helical filaments. Brain Res. 1984 Nov 19; 322(1):194-8. PMID: 6083822.
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  412. Kosik KS, Selkoe DJ, Sapirstein V. Possible modifications of vimentin following acquisition of triton insolubility. Biochem Int. 1984 Oct; 9(4):483-90. PMID: 6517954.
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  413. Rasool CG, Abraham C, Anderton BH, Haugh M, Kahn J, Selkoe DJ. Alzheimer's disease: immunoreactivity of neurofibrillary tangles with anti-neurofilament and anti-paired helical filament antibodies. Brain Res. 1984 Sep 24; 310(2):249-60. PMID: 6207891.
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  414. Bignami A, Selkoe DJ, Dahl D. Amyloid-like (Congophilic) neurofibrillary tangles do not react with neurofilament antisera in Alzheimer's cerebral cortex. Acta Neuropathol. 1984; 64(3):243-50. PMID: 6208743.
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  415. Ihara Y, Abraham C, Selkoe DJ. Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins. Nature. 1983 Aug 25-31; 304(5928):727-30. PMID: 6350889.
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  416. Kosik KS, Bradley WG, Good PF, Rasool CG, Selkoe DJ. Cholinergic function in lumbar aluminum myelopathy. J Neuropathol Exp Neurol. 1983 Jul; 42(4):365-75. PMID: 6190994.
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  417. Kosik KS, Gilbert JM, Selkoe DJ, Strocchi P. Characterization of postmortem human brain proteins by two-dimensional gel electrophoresis. J Neurochem. 1982 Dec; 39(6):1529-38. PMID: 7142987.
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  418. Selkoe DJ, Abraham C, Ihara Y. Brain transglutaminase: in vitro crosslinking of human neurofilament proteins into insoluble polymers. Proc Natl Acad Sci U S A. 1982 Oct; 79(19):6070-4. PMID: 6136967; PMCID: PMC347054.
  419. Selkoe DJ, Salazar FJ, Abraham C, Kosik KS. Huntington's disease: changes in striatal proteins reflect astrocytic gliosis. Brain Res. 1982 Aug 05; 245(1):117-25. PMID: 6214299.
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  420. Selkoe DJ, Ihara Y, Salazar FJ. Alzheimer's disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea. Science. 1982 Mar 05; 215(4537):1243-5. PMID: 6120571.
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  421. Dahl D, Selkoe DJ, Pero RT, Bignami A. Immunostaining of neurofibrillary tangles in Alzheimer's senile dementia with a neurofilament antiserum. J Neurosci. 1982 Jan; 2(1):113-9. PMID: 7033478.
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  422. Selkoe DJ, Brown BA, Salazar FJ, Marotta CA. Myelin basic protein in Alzheimer disease neuronal fractions and mammalian neurofilament preparations. Ann Neurol. 1981 Nov; 10(5):429-36. PMID: 6171190.
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  423. Breuer AC, Cuervo H, Selkoe DJ. Hyperpathia and sensory level due to parietal lobe arteriovenous malformation. Arch Neurol. 1981 Nov; 38(11):722-4. PMID: 7305704.
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  424. Rothenberg SJ, Selkoe D. Specific oculomotor deficit after diazepam. I. Saccadic eye movements. Psychopharmacology (Berl). 1981; 74(3):232-6. PMID: 6791230.
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  425. Rothenberg SJ, Selkoe D. Specific oculomotor deficit after diazepam. II. Smooth pursuit eye movements. Psychopharmacology (Berl). 1981; 74(3):237-40. PMID: 6791231.
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  426. Borges LF, Hallett M, Selkoe DJ, Welch K. The anterior tarsal tunnel syndrome. Report of two cases. J Neurosurg. 1981 Jan; 54(1):89-92. PMID: 7463126.
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  427. Selkoe DJ. Altered protein composition of isolated human cortical neurons in Alzheimer disease. Ann Neurol. 1980 Nov; 8(5):468-78. PMID: 7002020.
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  428. Rothenberg S, Schottenfeld S, Selkoe D, Gross K. Specific oculomotor deficit after acute methadone. II. Smooth pursuit eye movements. Psychopharmacology (Berl). 1980; 67(3):229-34. PMID: 6770400.
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  429. Rothenberg S, Schottenfeld S, Gross K, Selkoe D. Specific oculomotor deficit after acute methadone. I. Saccadic eye movements. Psychopharmacology (Berl). 1980; 67(3):221-7. PMID: 6770399.
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  430. Selkoe DJ. Nucleotide dependence of successive cycles of tubulin assembly. Brain Res. 1979 Aug 24; 172(2):382-6. PMID: 466483.
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  431. Selkoe DJ, Liem RK, Yen SH, Shelanski ML. Biochemical and immunological characterization of neurofilaments in experimental neurofibrillary degeneration induced by aluminum. Brain Res. 1979 Mar 16; 163(2):235-52. PMID: 371751.
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  432. Selkoe DJ, Myers RE. Neurologic and cardiovascular effects of hypotension in the monkey. Stroke. 1979 Mar-Apr; 10(2):147-57. PMID: 35862.
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  433. Liem RK, Selkoe DJ, Yen SH, Salomon G, Shelanski ML. New insights on the composition of neurofilaments. Res Publ Assoc Res Nerv Ment Dis. 1979; 57:145-52. PMID: 419331.
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  434. Selkoe DJ. Disease-related protein changes in purified neurons from Alzheimer's and Huntington's diseases. Trans Am Neurol Assoc. 1979; 104:70-4. PMID: 162259.
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  435. Selkoe DJ, Luckenbill-Edds L, Shelanski ML. Effects of neurotoxic industrial solvents on cultured neuroblastoma cells: methyl n-butyl ketone, n-hexane and derivatives. J Neuropathol Exp Neurol. 1978 Nov-Dec; 37(6):768-89. PMID: 739276.
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  436. Levitt LP, Selkoe DJ, Frankenfield B, Schoene W. Pure motor hemiplegia secondary to brain-stem tumour. J Neurol Neurosurg Psychiatry. 1975 Dec; 38(12):1240-3. PMID: 176327; PMCID: PMC492195.
  437. Shein HM, Britva A, Hess HH, Selkoe DJ. Isolation of hamster brain astroglia by in vitro cultivation and subcutaneous growth, and content of cerebroside, ganglioside, RNA and DNA. Brain Res. 1970 May 04; 19(3):497-501. PMID: 4910467.
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  438. Selkoe DJ. Familial hyperprolinemia and mental retardation. A second metabolic type. Neurology. 1969 May; 19(5):494-502. PMID: 5815222.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.