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Flavia V. Castelino, M.D.

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Physician Scientist Development Award, American College of Rheumatology
Distinguished Fellow Award, American College of Rheumatology
Walter A. Coyle Memorial Research Award, Scleroderma Foundation

Dr. Flavia Castelino is the Director of the Scleroderma Program at Massachusetts General Hospital and Assistant Professor of Medicine at Harvard Medical School. She is a board-certified physician in the Division of Rheumatology and she specializes in the treatment of scleroderma and connective tissue disease-associated lung disease.

Her research focuses on the role of lipid mediators in scleroderma fibrosis. Dr. Castelino is a member of the Early Career Investigator Subcommittee of the American College of Rheumatology and the Scleroderma Clinical Trials Consortium. She acts as a reviewer for multiple rheumatology journals including Arthritis and Rheumatology, Arthritis Care and Research and Arthritis Research and Therapy. She is the recipient of numerous awards including the American College of Rheumatology Physician-Scientist Development Award and the Scleroderma Foundation Walter A. Coyle Memorial Research Award. Recently, she was awarded a National Institute of Health research grant to study the role of a lipid mediator, lysophosphatidic acid in scleroderma fibrosis.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08AR062592 (CASTELINO, FLAVIA V) Apr 1, 2012 - Sep 30, 2017
    The Role Of Lysophosphatidic Acid (LPA) And Its Receptor, LPA1 In Scleroderma
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bernstein EJ, Assassi S, Castelino FV, Chung L, Correia C, Evnin LB, Frech TM, Gordon JK, Skaug BA, Hant FN, Hummers LK, Sandorfi N, Shah AA, Shanmugam VK, Steen VD, Khanna D. Computed Tomography of the Chest to Screen for Interstitial Lung Disease in Patients With Systemic Sclerosis at Expert Scleroderma Centers in the United States. ACR Open Rheumatol. 2022 Jul; 4(7):596-602. PMID: 35460213; PMCID: PMC9274361.
  2. Wallace ZS, Cook C, Finkelstein-Fox L, Fu X, Castelino FV, Choi HK, Perugino C, Stone JH, Park ER, Hall DL. The Association of Illness-related Uncertainty With Mental Health in Systemic Autoimmune Rheumatic Diseases. J Rheumatol. 2022 09; 49(9):1058-1066. PMID: 35365580; PMCID: PMC9525460.
    Citations:    Fields:    
  3. Valenzuela A, Stevens K, Chung MP, Rodriguez-Reyna TS, Proudman S, Baron M, Castelino FV, Hsu V, Green L, Galdo FD, Li S, Fiorentino D, Chung L. Change in calcinosis over 1 year using the scleroderma clinical trials consortium radiologic scoring system for calcinosis of the hands in patients with systemic sclerosis. Semin Arthritis Rheum. 2022 04; 53:151980. PMID: 35183935.
    Citations: 1     Fields:    Translation:Humans
  4. Castelino FV, VanBuren JM, Startup E, Assassi S, Bernstein EJ, Chung L, Correia C, Evnin LB, Frech TM, Gordon JK, Hant FN, Hummers LK, Khanna D, Sandorfi N, Shah AA, Shanmugam VK, Steen V. Baseline characteristics of systemic sclerosis patients with restrictive lung disease in a multi-center US-based longitudinal registry. Int J Rheum Dis. 2022 Feb; 25(2):163-174. PMID: 34841681.
    Citations:    Fields:    Translation:Humans
  5. D'Silva KM, Ventura IB, Bolster MB, Castelino FV, Sharma A, Little BP, Adegunsoye A, Strek ME, Choi H, Montesi SB. Rituximab for interstitial pneumonia with autoimmune features at two medical centres. Rheumatol Adv Pract. 2021 Nov; 5(Suppl 2):ii1-ii9. PMID: 34755024; PMCID: PMC8570147.
  6. Jaafar S, Lescoat A, Huang S, Gordon J, Hinchcliff M, Shah AA, Assassi S, Domsic R, Bernstein EJ, Steen V, Elliott S, Hant F, Castelino FV, Shanmugam VK, Correia C, Varga J, Nagaraja V, Roofeh D, Frech T, Khanna D. Clinical characteristics, visceral involvement, and mortality in at-risk or early diffuse systemic sclerosis: a longitudinal analysis of an observational prospective multicenter US cohort. Arthritis Res Ther. 2021 06 14; 23(1):170. PMID: 34127049; PMCID: PMC8201684.
    Citations: 6     Fields:    Translation:Humans
  7. Assassi S, Li N, Volkmann ER, Mayes MD, Rünger D, Ying J, Roth MD, Hinchcliff M, Khanna D, Frech T, Clements PJ, Furst DE, Goldin J, Bernstein EJ, Castelino FV, Domsic RT, Gordon JK, Hant FN, Shah AA, Shanmugam VK, Steen VD, Elashoff RM, Tashkin DP. Predictive Significance of Serum Interferon-Inducible Protein Score for Response to Treatment in Systemic Sclerosis-Related Interstitial Lung Disease. Arthritis Rheumatol. 2021 06; 73(6):1005-1013. PMID: 33350170; PMCID: PMC8169525.
    Citations: 6     Fields:    Translation:Humans
  8. Castelino FV, Moua T. Detection and Management of Interstitial Lung Diseases Associated With Connective Tissue Diseases. ACR Open Rheumatol. 2021 May; 3(5):295-304. PMID: 33779080.
    Citations: 2     
  9. Frech TM, VanBuren JM, Startup E, Assassi S, Bernstein EJ, Castelino FV, Chung L, Correia C, Gordon JK, Hant FN, Hummers L, Khanna D, Sandorfi N, Shah AA, Shanmugam VK, Steen V, Evnin L. Does hand involvement in systemic sclerosis limit completion of patient-reported outcome measures? Clin Rheumatol. 2021 Mar; 40(3):965-971. PMID: 33094395; PMCID: PMC7897231.
    Citations: 1     Fields:    Translation:Humans
  10. Chung L, Spino C, McLain R, Johnson SR, Denton CP, Molitor JA, Steen VD, Lafyatis R, Simms RW, Kafaja S, Frech TM, Hsu V, Domsic RT, Pope JE, Gordon JK, Mayes MD, Sandorfi N, Hant FN, Bernstein EJ, Chatterjee S, Castelino FV, Ajam A, Allanore Y, Matucci-Cerinic M, Whitfield ML, Distler O, Singer O, Young A, Nagaraja V, Fox DA, Furst DE, Khanna D. Safety and efficacy of abatacept in early diffuse cutaneous systemic sclerosis (ASSET): open-label extension of a phase 2, double-blind randomised trial. Lancet Rheumatol. 2020 Dec; 2(12):e743-e753. PMID: 34966900; PMCID: PMC8713509.
    Citations: 5     
  11. Valenzuela A, Baron M, Rodriguez-Reyna TS, Proudman S, Khanna D, Young A, Hinchcliff M, Steen V, Gordon J, Hsu V, Castelino FV, Schoenfeld S, Li S, Wu JY, Fiorentino D, Chung L. Calcinosis is associated with ischemic manifestations and increased disability in patients with systemic sclerosis. Semin Arthritis Rheum. 2020 10; 50(5):891-896. PMID: 32898758.
    Citations: 4     Fields:    Translation:Humans
  12. Khanna D, Spino C, Johnson S, Chung L, Whitfield ML, Denton CP, Berrocal V, Franks J, Mehta B, Molitor J, Steen VD, Lafyatis R, Simms RW, Gill A, Kafaja S, Frech TM, Hsu V, Domsic RT, Pope JE, Gordon JK, Mayes MD, Schiopu E, Young A, Sandorfi N, Park J, Hant FN, Bernstein EJ, Chatterjee S, Castelino FV, Ajam A, Wang Y, Wood T, Allanore Y, Matucci-Cerinic M, Distler O, Singer O, Bush E, Fox DA, Furst DE. Abatacept in Early Diffuse Cutaneous Systemic Sclerosis: Results of a Phase II Investigator-Initiated, Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial. Arthritis Rheumatol. 2020 01; 72(1):125-136. PMID: 31342624; PMCID: PMC6935399.
    Citations: 59     Fields:    Translation:HumansCTClinical Trials
  13. Skaug B, Khanna D, Swindell WR, Hinchcliff ME, Frech TM, Steen VD, Hant FN, Gordon JK, Shah AA, Zhu L, Zheng WJ, Browning JL, Barron AMS, Wu M, Visvanathan S, Baum P, Franks JM, Whitfield ML, Shanmugam VK, Domsic RT, Castelino FV, Bernstein EJ, Wareing N, Lyons MA, Ying J, Charles J, Mayes MD, Assassi S. Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile. Ann Rheum Dis. 2020 03; 79(3):379-386. PMID: 31767698.
    Citations: 26     Fields:    Translation:HumansCells
  14. Shanmugam VK, Frech TM, Steen VD, Hummers LK, Shah AA, Bernstein EJ, Khanna D, Gordon JK, Castelino FV, Chung L, Hant FN, Startup E, VanBuren JM, Evnin LB, Assassi S. Collaborative National Quality and Efficacy Registry (CONQUER) for Scleroderma: outcomes from a multicenter US-based systemic sclerosis registry. Clin Rheumatol. 2020 Jan; 39(1):93-102. PMID: 31667644.
    Citations: 3     Fields:    Translation:Humans
  15. Castelino FV, Dellaripa PF. Recent progress in systemic sclerosis-interstitial lung disease. Curr Opin Rheumatol. 2018 11; 30(6):570-575. PMID: 30234724.
    Citations: 2     Fields:    Translation:Humans
  16. Ogdie A, Sparks JA, Angeles-Han ST, Bush K, Castelino FV, Golding A, Jiang Y, Kahlenberg JM, Kim AHJ, Lee YC, Machireddy K, Ombrello MJ, Shah AA, Wallace ZS, Nigrovic PA, Makris UE. Barriers and Facilitators of Mentoring for Trainees and Early Career Investigators in Rheumatology Research: Current State, Identification of Needs, and Road Map to an Inter-Institutional Adult Rheumatology Mentoring Program. Arthritis Care Res (Hoboken). 2018 03; 70(3):445-453. PMID: 28544766.
    Citations: 5     Fields:    Translation:Humans
  17. Schoenfeld SR, Castelino FV. Evaluation and management approaches for scleroderma lung disease. Ther Adv Respir Dis. 2017 08; 11(8):327-340. PMID: 28621173.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  18. Castelino FV, Bain G, Pace VA, Black KE, George L, Probst CK, Goulet L, Lafyatis R, Tager AM. An Autotaxin/Lysophosphatidic Acid/Interleukin-6 Amplification Loop Drives Scleroderma Fibrosis. Arthritis Rheumatol. 2016 12; 68(12):2964-2974. PMID: 27390295; PMCID: PMC5125861.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  19. Honigberg MC, Wallace ZS, Castelino FV. A 30-Year-Old Woman With Chest Pain and Coronary Artery Aneurysms. Arthritis Care Res (Hoboken). 2016 Sep; 68(9):1378-84. PMID: 25220598.
    Citations:    Fields:    Translation:Humans
  20. Black KE, Berdyshev E, Bain G, Castelino FV, Shea BS, Probst CK, Fontaine BA, Bronova I, Goulet L, Lagares D, Ahluwalia N, Knipe RS, Natarajan V, Tager AM. Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis. FASEB J. 2016 06; 30(6):2435-50. PMID: 27006447; PMCID: PMC4871797.
    Citations: 15     Fields:    Translation:Animals
  21. Mattoo H, Mahajan VS, Maehara T, Deshpande V, Della-Torre E, Wallace ZS, Kulikova M, Drijvers JM, Daccache J, Carruthers MN, Castelino FV, Stone JR, Stone JH, Pillai S. Clonal expansion of CD4(+) cytotoxic T lymphocytes in patients with IgG4-related disease. J Allergy Clin Immunol. 2016 09; 138(3):825-838. PMID: 26971690; PMCID: PMC5014627.
    Citations: 106     Fields:    Translation:HumansCells
  22. Ogdie A, Shah AA, Makris UE, Jiang Y, Nelson AE, Kim AHJ, Angeles-Han ST, Castelino FV, Golding A, Muscal E, Kahlenberg JM, Barg FK. Barriers to and Facilitators of a Career as a Physician-Scientist Among Rheumatologists in the US. Arthritis Care Res (Hoboken). 2015 Sep; 67(9):1191-1201. PMID: 25708626.
    Citations: 9     Fields:    Translation:Humans
  23. Mittoo S, Frankel S, LeSage D, Strand V, Shah AA, Christopher-Stine L, Danoff S, Hummers LK, Swigris JJ, Huscher D, Christensen AM, Cenac SL, Erbil JK, Ferguson S, Garcia-Valladares I, Grewal HK, Orbai AM, Smith KC, Tran M, Bingham CO, Castelino FV, Fischer A, Saketkoo LA. Patient Perspectives in OMERACT Provide an Anchor for Future Metric Development and Improved Approaches to Healthcare Delivery in Connective Tissue Disease Related Interstitial Lung Disease (CTD-ILD). Curr Respir Med Rev. 2015 Jun; 11(2):175-183. PMID: 26568747; PMCID: PMC4643941.
    Citations: 14     
  24. Schoenfeld SR, Castelino FV. Interstitial lung disease in scleroderma. Rheum Dis Clin North Am. 2015 May; 41(2):237-48. PMID: 25836640; PMCID: PMC4385198.
    Citations: 22     Fields:    Translation:Humans
  25. Castelino FV, Varga J. Emerging cellular and molecular targets in fibrosis: implications for scleroderma pathogenesis and targeted therapy. Curr Opin Rheumatol. 2014 Nov; 26(6):607-14. PMID: 25191991.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  26. Saketkoo LA, Mittoo S, Huscher D, Khanna D, Dellaripa PF, Distler O, Flaherty KR, Frankel S, Oddis CV, Denton CP, Fischer A, Kowal-Bielecka OM, LeSage D, Merkel PA, Phillips K, Pittrow D, Swigris J, Antoniou K, Baughman RP, Castelino FV, Christmann RB, Christopher-Stine L, Collard HR, Cottin V, Danoff S, Highland KB, Hummers L, Shah AA, Kim DS, Lynch DA, Miller FW, Proudman SM, Richeldi L, Ryu JH, Sandorfi N, Sarver C, Wells AU, Strand V, Matteson EL, Brown KK, Seibold JR. Connective tissue disease related interstitial lung diseases and idiopathic pulmonary fibrosis: provisional core sets of domains and instruments for use in clinical trials. Thorax. 2014 May; 69(5):428-36. PMID: 24368713; PMCID: PMC3995282.
    Citations: 36     Fields:    Translation:Humans
  27. Castelino FV, Varga J. Current status of systemic sclerosis biomarkers: applications for diagnosis, management and drug development. Expert Rev Clin Immunol. 2013 Nov; 9(11):1077-90. PMID: 24168414.
    Citations: 7     Fields:    Translation:HumansAnimals
  28. Castelino FV. Lipids and eicosanoids in fibrosis: emerging targets for therapy. Curr Opin Rheumatol. 2012 Nov; 24(6):649-55. PMID: 22810365.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  29. Castelino FV, Seiders J, Bain G, Brooks SF, King CD, Swaney JS, Lorrain DS, Chun J, Luster AD, Tager AM. Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma. Arthritis Rheum. 2011 May; 63(5):1405-15. PMID: 21305523; PMCID: PMC3086986.
    Citations: 62     Fields:    Translation:Animals
  30. Castelino FV, Varga J. Interstitial lung disease in connective tissue diseases: evolving concepts of pathogenesis and management. Arthritis Res Ther. 2010; 12(4):213. PMID: 20735863.
    Citations: 56     Fields:    Translation:Humans
  31. Castelino FV, Goldberg H, Dellaripa PF. The impact of rheumatological evaluation in the management of patients with interstitial lung disease. Rheumatology (Oxford). 2011 Mar; 50(3):489-93. PMID: 20685802.
    Citations: 16     Fields:    Translation:Humans
  32. Castelino FV, Bhattacharyya S, Varga J. Tyrosine kinase inhibitors in systemic sclerosis: the case for imatinib. Curr Rheumatol Rep. 2009 Jul; 11(3):161-3. PMID: 19604458.
    Citations:    Fields:    
  33. Castelino FV, Wasfy JH, Collier D. A 36-year-old man with paresthesias and a headache. Arthritis Rheum. 2008 Sep 15; 59(9):1358-65. PMID: 18759310.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.