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Flavia V. Castelino, M.D.

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Biography
2010
Physician Scientist Development Award, American College of Rheumatology
2010
Distinguished Fellow Award, American College of Rheumatology
2012
Walter A. Coyle Memorial Research Award, Scleroderma Foundation

Overview
Dr. Flavia Castelino is the Director of the Scleroderma Program at Massachusetts General Hospital and Assistant Professor of Medicine at Harvard Medical School. She is a board-certified physician in the Division of Rheumatology and she specializes in the treatment of scleroderma and connective tissue disease-associated lung disease.

Her research focuses on the role of lipid mediators in scleroderma fibrosis. Dr. Castelino is a member of the Early Career Investigator Subcommittee of the American College of Rheumatology and the Scleroderma Clinical Trials Consortium. She acts as a reviewer for multiple rheumatology journals including Arthritis and Rheumatology, Arthritis Care and Research and Arthritis Research and Therapy. She is the recipient of numerous awards including the American College of Rheumatology Physician-Scientist Development Award and the Scleroderma Foundation Walter A. Coyle Memorial Research Award. Recently, she was awarded a National Institute of Health research grant to study the role of a lipid mediator, lysophosphatidic acid in scleroderma fibrosis.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08AR062592 (CASTELINO, FLAVIA V) Apr 1, 2012 - Mar 31, 2017
    NIH/NIAMS
    The Role Of Lysophosphatidic Acid (LPA) And Its Receptor, LPA1 In Scleroderma
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Castelino FV, Dellaripa PF. Recent progress in systemic sclerosis-interstitial lung disease. Curr Opin Rheumatol. 2018 Nov; 30(6):570-575. PMID: 30234724.
    Citations:    Fields:    
  2. Ogdie A, Sparks JA, Angeles-Han ST, Bush K, Castelino FV, Golding A, Jiang Y, Kahlenberg JM, Kim AHJ, Lee YC, Machireddy K, Ombrello MJ, Shah AA, Wallace ZS, Nigrovic PA, Makris UE. Barriers and Facilitators of Mentoring for Trainees and Early Career Investigators in Rheumatology Research: Current State, Identification of Needs, and Road Map to an Inter-Institutional Adult Rheumatology Mentoring Program. Arthritis Care Res (Hoboken). 2018 03; 70(3):445-453. PMID: 28544766.
    Citations:    Fields:    Translation:Humans
  3. Schoenfeld SR, Castelino FV. Evaluation and management approaches for scleroderma lung disease. Ther Adv Respir Dis. 2017 08; 11(8):327-340. PMID: 28621173.
    Citations:    Fields:    Translation:HumansPHPublic Health
  4. Castelino FV, Bain G, Pace VA, Black KE, George L, Probst CK, Goulet L, Lafyatis R, Tager AM. An Autotaxin/Lysophosphatidic Acid/Interleukin-6 Amplification Loop Drives Scleroderma Fibrosis. Arthritis Rheumatol. 2016 12; 68(12):2964-2974. PMID: 27390295.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  5. Honigberg MC, Wallace ZS, Castelino FV. A 30-Year-Old Woman With Chest Pain and Coronary Artery Aneurysms. Arthritis Care Res (Hoboken). 2016 Sep; 68(9):1378-84. PMID: 25220598.
    Citations:    Fields:    Translation:Humans
  6. Black KE, Berdyshev E, Bain G, Castelino FV, Shea BS, Probst CK, Fontaine BA, Bronova I, Goulet L, Lagares D, Ahluwalia N, Knipe RS, Natarajan V, Tager AM. Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis. FASEB J. 2016 06; 30(6):2435-50. PMID: 27006447.
    Citations: 2     Fields:    Translation:Animals
  7. Mattoo H, Mahajan VS, Maehara T, Deshpande V, Della-Torre E, Wallace ZS, Kulikova M, Drijvers JM, Daccache J, Carruthers MN, Castelino FV, Stone JR, Stone JH, Pillai S. Clonal expansion of CD4(+) cytotoxic T lymphocytes in patients with IgG4-related disease. J Allergy Clin Immunol. 2016 09; 138(3):825-838. PMID: 26971690.
    Citations: 35     Fields:    Translation:HumansCells
  8. Ogdie A, Shah AA, Makris UE, Jiang Y, Nelson AE, Kim AH, Angeles-Han ST, Castelino FV, Golding A, Muscal E, Kahlenberg JM, Barg FK. Barriers to and Facilitators of a Career as a Physician-Scientist Among Rheumatologists in the US. Arthritis Care Res (Hoboken). 2015 Sep; 67(9):1191-201. PMID: 25708626.
    Citations: 5     Fields:    Translation:Humans
  9. Mittoo S, Frankel S, LeSage D, Strand V, Shah AA, Christopher-Stine L, Danoff S, Hummers LK, Swigris JJ, Huscher D, Christensen AM, Cenac SL, Erbil JK, Ferguson S, Garcia-Valladares I, Grewal HK, Orbai AM, Smith KC, Tran M, Bingham CO, Castelino FV, Fischer A, Saketkoo LA. Patient Perspectives in OMERACT Provide an Anchor for Future Metric Development and Improved Approaches to Healthcare Delivery in Connective Tissue Disease Related Interstitial Lung Disease (CTD-ILD). Curr Respir Med Rev. 2015 Jun; 11(2):175-183. PMID: 26568747.
    Citations: 3     
  10. Schoenfeld SR, Castelino FV. Interstitial lung disease in scleroderma. Rheum Dis Clin North Am. 2015 May; 41(2):237-48. PMID: 25836640.
    Citations: 6     Fields:    Translation:Humans
  11. Castelino FV, Varga J. Emerging cellular and molecular targets in fibrosis: implications for scleroderma pathogenesis and targeted therapy. Curr Opin Rheumatol. 2014 Nov; 26(6):607-14. PMID: 25191991.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  12. Saketkoo LA, Mittoo S, Huscher D, Khanna D, Dellaripa PF, Distler O, Flaherty KR, Frankel S, Oddis CV, Denton CP, Fischer A, Kowal-Bielecka OM, LeSage D, Merkel PA, Phillips K, Pittrow D, Swigris J, Antoniou K, Baughman RP, Castelino FV, Christmann RB, Christopher-Stine L, Collard HR, Cottin V, Danoff S, Highland KB, Hummers L, Shah AA, Kim DS, Lynch DA, Miller FW, Proudman SM, Richeldi L, Ryu JH, Sandorfi N, Sarver C, Wells AU, Strand V, Matteson EL, Brown KK, Seibold JR. Connective tissue disease related interstitial lung diseases and idiopathic pulmonary fibrosis: provisional core sets of domains and instruments for use in clinical trials. Thorax. 2014 May; 69(5):428-36. PMID: 24368713.
    Citations: 22     Fields:    Translation:Humans
  13. Castelino FV, Varga J. Current status of systemic sclerosis biomarkers: applications for diagnosis, management and drug development. Expert Rev Clin Immunol. 2013 Nov; 9(11):1077-90. PMID: 24168414.
    Citations: 7     Fields:    Translation:HumansAnimals
  14. Castelino FV. Lipids and eicosanoids in fibrosis: emerging targets for therapy. Curr Opin Rheumatol. 2012 Nov; 24(6):649-55. PMID: 22810365.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  15. Castelino FV, Seiders J, Bain G, Brooks SF, King CD, Swaney JS, Lorrain DS, Chun J, Luster AD, Tager AM. Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma. Arthritis Rheum. 2011 May; 63(5):1405-15. PMID: 21305523.
    Citations: 37     Fields:    Translation:Animals
  16. Castelino FV, Varga J. Interstitial lung disease in connective tissue diseases: evolving concepts of pathogenesis and management. Arthritis Res Ther. 2010; 12(4):213. PMID: 20735863.
    Citations: 27     Fields:    Translation:Humans
  17. Castelino FV, Goldberg H, Dellaripa PF. The impact of rheumatological evaluation in the management of patients with interstitial lung disease. Rheumatology (Oxford). 2011 Mar; 50(3):489-93. PMID: 20685802.
    Citations: 9     Fields:    Translation:Humans
  18. Castelino FV, Bhattacharyya S, Varga J. Tyrosine kinase inhibitors in systemic sclerosis: the case for imatinib. Curr Rheumatol Rep. 2009 Jul; 11(3):161-3. PMID: 19604458.
    Citations:    Fields:    
  19. Castelino FV, Wasfy JH, Collier D. A 36-year-old man with paresthesias and a headache. Arthritis Rheum. 2008 Sep 15; 59(9):1358-65. PMID: 18759310.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.