Harvard Catalyst Profiles

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Leena Pradhan-Nabzdyk, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21HL133821 (PRADHAN-NABZDYK, LEENA) Jul 15, 2016 - Jun 30, 2018
    Development of Small Molecule Inhibitors of IL-18 to Prevent Intimal Hyperplasia
    Role: Principal Investigator
  2. T35HL110843 (LOGERFO, FRANK W) Aug 1, 2013 - Jul 31, 2023
    Harvard Longwood Short-Term Research Training in Vascular Surgery
    Role: Co-Principal Investigator
  3. R01NS066205 (VEVES, ARISTIDIS) Jun 1, 2010 - May 31, 2015
    Role of Neuropeptides in Diabetic Foot Problems
    Role: Co-Principal Investigator
  4. T32HL007734 (LOGERFO, FRANK W) Jul 1, 1997 - Jun 30, 2024
    Harvard Longwood Research Training in Vascular Surgery
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Huynh C, Shih TY, Mammoo A, Samant A, Pathan S, Nelson DW, Ferran C, Mooney D, LoGerfo F, Pradhan-Nabzdyk L. Delivery of targeted gene therapies using a hybrid cryogel-coated prosthetic vascular graft. PeerJ. 2019; 7:e7377. PMID: 31497383.
  2. Nabzdyk CS, Pradhan-Nabzdyk L, LoGerfo FW. RNAi therapy to the wall of arteries and veins: anatomical, physiologic, and pharmacological considerations. J Transl Med. 2017 07 28; 15(1):164. PMID: 28754174.
    Citations: 2     Fields:    Translation:HumansAnimals
  3. Bodewes TC, Johnson JM, Auster M, Huynh C, Muralidharan S, Contreras M, LoGerfo FW, Pradhan-Nabzdyk L. Intraluminal delivery of thrombospondin-2 small interfering RNA inhibits the vascular response to injury in a rat carotid balloon angioplasty model. FASEB J. 2017 01; 31(1):109-119. PMID: 27671229.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. Tellechea A, Leal EC, Kafanas A, Auster ME, Kuchibhotla S, Ostrovsky Y, Tecilazich F, Baltzis D, Zheng Y, Carvalho E, Zabolotny JM, Weng Z, Petra A, Patel A, Panagiotidou S, Pradhan-Nabzdyk L, Theoharides TC, Veves A. Mast Cells Regulate Wound Healing in Diabetes. Diabetes. 2016 07; 65(7):2006-19. PMID: 27207516.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  5. Raof NA, Rajamani D, Chu HC, Gurav A, Johnson JM, LoGerfo FW, Pradhan-Nabzdyk L, Bhasin M. The effects of transfection reagent polyethyleneimine (PEI) and non-targeting control siRNAs on global gene expression in human aortic smooth muscle cells. BMC Genomics. 2016 Jan 05; 17:20. PMID: 26728506.
    Citations: 5     Fields:    Translation:Humans
  6. Tellechea A, Silva EA, Min J, Leal EC, Auster ME, Pradhan-Nabzdyk L, Shih W, Mooney DJ, Veves A. Alginate and DNA Gels Are Suitable Delivery Systems for Diabetic Wound Healing. Int J Low Extrem Wounds. 2015 Jun; 14(2):146-53. PMID: 26032947.
    Citations: 5     Fields:    Translation:Animals
  7. You JO, Rafat M, Almeda D, Maldonado N, Guo P, Nabzdyk CS, Chun M, LoGerfo FW, Hutchinson JW, Pradhan-Nabzdyk LK, Auguste DT. pH-responsive scaffolds generate a pro-healing response. Biomaterials. 2015 Jul; 57:22-32. PMID: 25956194.
    Citations:    Fields:    Translation:AnimalsCells
  8. Leal EC, Carvalho E, Tellechea A, Kafanas A, Tecilazich F, Kearney C, Kuchibhotla S, Auster ME, Kokkotou E, Mooney DJ, LoGerfo FW, Pradhan-Nabzdyk L, Veves A. Substance P promotes wound healing in diabetes by modulating inflammation and macrophage phenotype. Am J Pathol. 2015 Jun; 185(6):1638-48. PMID: 25871534.
    Citations: 14     Fields:    Translation:AnimalsCells
  9. Pradhan-Nabzdyk L, Huang C, LoGerfo FW, Nabzdyk CS. Current siRNA targets in the prevention and treatment of intimal hyperplasia. Discov Med. 2014 Sep; 18(98):125-32. PMID: 25227753.
    Citations: 2     Fields:    Translation:HumansAnimals
  10. Pradhan-Nabzdyk L, Huang C, LoGerfo FW, Nabzdyk CS. Current siRNA targets in atherosclerosis and aortic aneurysm. Discov Med. 2014 May; 17(95):233-46. PMID: 24882715.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  11. Nabzdyk CS, Chun MC, Oliver-Allen HS, Pathan SG, Phaneuf MD, You JO, Pradhan-Nabzdyk LK, LoGerfo FW. Gene silencing in human aortic smooth muscle cells induced by PEI-siRNA complexes released from dip-coated electrospun poly(ethylene terephthalate) grafts. Biomaterials. 2014 Mar; 35(9):3071-9. PMID: 24397987.
    Citations: 5     Fields:    Translation:HumansCells
  12. Tecilazich F, Dinh T, Pradhan-Nabzdyk L, Leal E, Tellechea A, Kafanas A, Gnardellis C, Magargee ML, Dejam A, Toxavidis V, Tigges JC, Carvalho E, Lyons TE, Veves A. Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers. PLoS One. 2013; 8(12):e83314. PMID: 24358275.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  13. Pradhan Nabzdyk L, Kuchibhotla S, Guthrie P, Chun M, Auster ME, Nabzdyk C, Deso S, Andersen N, Gnardellis C, LoGerfo FW, Veves A. Expression of neuropeptides and cytokines in a rabbit model of diabetic neuroischemic wound healing. J Vasc Surg. 2013 Sep; 58(3):766-75.e12. PMID: 23755976.
    Citations: 14     Fields:    Translation:AnimalsCells
  14. Nabzdyk CS, Chun M, Pradhan Nabzdyk L, Yoshida S, LoGerfo FW. Differential susceptibility of human primary aortic and coronary artery vascular cells to RNA interference. Biochem Biophys Res Commun. 2012 Aug 24; 425(2):261-5. PMID: 22842581.
    Citations: 8     Fields:    Translation:HumansCells
  15. Bhasin M, Huang Z, Pradhan-Nabzdyk L, Malek JY, LoGerfo PJ, Contreras M, Guthrie P, Csizmadia E, Andersen N, Kocher O, Ferran C, LoGerfo FW. Temporal network based analysis of cell specific vein graft transcriptome defines key pathways and hub genes in implantation injury. PLoS One. 2012; 7(6):e39123. PMID: 22720046.
    Citations: 13     Fields:    Translation:AnimalsCells
  16. Dinh T, Tecilazich F, Kafanas A, Doupis J, Gnardellis C, Leal E, Tellechea A, Pradhan L, Lyons TE, Giurini JM, Veves A. Mechanisms involved in the development and healing of diabetic foot ulceration. Diabetes. 2012 Nov; 61(11):2937-47. PMID: 22688339.
    Citations: 42     Fields:    Translation:Humans
  17. Ejaz A, LoGerfo FW, Khabbaz K, Pradhan L. Expression of Neuropeptide Y, Substance P, and their receptors in the right atrium of diabetic patients. Clin Transl Sci. 2011 Oct; 4(5):346-50. PMID: 22029806.
    Citations: 5     Fields:    Translation:Humans
  18. Yoshida S, Nabzdyk CS, Pradhan L, LoGerfo FW. Thrombospondin-2 gene silencing in human aortic smooth muscle cells improves cell attachment. J Am Coll Surg. 2011 Nov; 213(5):668-76. PMID: 21840228.
    Citations: 4     Fields:    Translation:HumansCells
  19. Ejaz A, LoGerfo FW, Pradhan L. Diabetic neuropathy and heart failure: role of neuropeptides. Expert Rev Mol Med. 2011 Aug 10; 13:e26. PMID: 21831336.
    Citations: 5     Fields:    Translation:HumansAnimals
  20. Jain M, LoGerfo FW, Guthrie P, Pradhan L. Effect of hyperglycemia and neuropeptides on interleukin-8 expression and angiogenesis in dermal microvascular endothelial cells. J Vasc Surg. 2011 Jun; 53(6):1654-60.e2. PMID: 21609799.
    Citations: 7     Fields:    Translation:HumansCells
  21. Nabzdyk CS, Chun M, Pradhan L, Logerfo FW. High throughput RNAi assay optimization using adherent cell cytometry. J Transl Med. 2011 Apr 25; 9:48. PMID: 21518450.
    Citations: 14     Fields:    Translation:HumansCells
  22. Andersen ND, Chopra A, Monahan TS, Malek JY, Jain M, Pradhan L, Ferran C, LoGerfo FW. Endothelial cells are susceptible to rapid siRNA transfection and gene silencing ex vivo. J Vasc Surg. 2010 Dec; 52(6):1608-15. PMID: 20801607.
    Citations: 3     Fields:    Translation:Humans
  23. Pradhan L, Cai X, Wu S, Andersen ND, Martin M, Malek J, Guthrie P, Veves A, Logerfo FW. Gene expression of pro-inflammatory cytokines and neuropeptides in diabetic wound healing. J Surg Res. 2011 May 15; 167(2):336-42. PMID: 20070982.
    Citations: 17     Fields:    Translation:Animals
  24. Nabzdyk C, Pradhan L, Molina J, Perin E, Paniagua D, Rosenstrauch D. Review: auricular chondrocytes - from benchwork to clinical applications. In Vivo. 2009 May-Jun; 23(3):369-80. PMID: 19454501.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  25. Pradhan L, Nabzdyk C, Andersen ND, LoGerfo FW, Veves A. Inflammation and neuropeptides: the connection in diabetic wound healing. Expert Rev Mol Med. 2009 Jan 13; 11:e2. PMID: 19138453.
    Citations: 41     Fields:    Translation:HumansAnimals
  26. Monahan TS, Andersen ND, Martin MC, Malek JY, Shrikhande GV, Pradhan L, Ferran C, LoGerfo FW. MARCKS silencing differentially affects human vascular smooth muscle and endothelial cell phenotypes to inhibit neointimal hyperplasia in saphenous vein. FASEB J. 2009 Feb; 23(2):557-64. PMID: 18940893.
    Citations: 17     Fields:    Translation:HumansCells
  27. Pradhan L, Mondal D, Chandra S, Ali M, Agrawal KC. Molecular analysis of cocaine-induced endothelial dysfunction: role of endothelin-1 and nitric oxide. Cardiovasc Toxicol. 2008 Dec; 8(4):161-71. PMID: 18813882.
    Citations: 12     Fields:    Translation:HumansCells
  28. Kendirci M, Pradhan L, Trost L, Gur S, Chandra S, Agrawal KC, Hellstrom WJ. Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use. Eur Urol. 2007 Aug; 52(2):555-63. PMID: 17420087.
    Citations: 3     Fields:    Translation:Animals
  29. Andersen ND, Monahan TS, Malek JY, Jain M, Daniel S, Caron LD, Pradhan L, Ferran C, Logerfo FW. Comparison of gene silencing in human vascular cells using small interfering RNAs. J Am Coll Surg. 2007 Mar; 204(3):399-408. PMID: 17324773.
    Citations: 10     Fields:    Translation:HumansCells
  30. Reiser J, Zhang XY, Hemenway CS, Mondal D, Pradhan L, La Russa VF. Potential of mesenchymal stem cells in gene therapy approaches for inherited and acquired diseases. Expert Opin Biol Ther. 2005 Dec; 5(12):1571-84. PMID: 16318421.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  31. Pradhan L, Dabisch PA, Liles JT, Murthy SN, Baber SR, Simpson SA, Agrawal KC, Kadowitz PJ. Effect of binge cocaine treatment on hindlimb vascular function. J Appl Toxicol. 2005 Nov-Dec; 25(6):479-90. PMID: 16092079.
    Citations: 1     Fields:    Translation:Animals
  32. Liles JT, Dabisch PA, Hude KE, Pradhan L, Varner KJ, Porter JR, Hicks AR, Corll C, Baber SR, Kadowitz PJ. Pressor responses to ephedrine are mediated by a direct mechanism in the rat. J Pharmacol Exp Ther. 2006 Jan; 316(1):95-105. PMID: 16002460.
    Citations: 4     Fields:    Translation:Animals
  33. Bivalacqua TJ, Usta MF, Kendirci M, Pradhan L, Alvarez X, Champion HC, Kadowitz PJ, Hellstrom WJ. Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy. J Sex Med. 2005 Mar; 2(2):187-97; discussion 197-8. PMID: 16422885.
    Citations: 30     Fields:    Translation:AnimalsCells
  34. Mondal D, Pradhan L, LaRussa VF. Signal transduction pathways involved in the lineage-differentiation of NSCs: can the knowledge gained from blood be used in the brain? Cancer Invest. 2004; 22(6):925-43. PMID: 15641490.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  35. Mondal D, Pradhan L, Ali M, Agrawal KC. HAART drugs induce oxidative stress in human endothelial cells and increase endothelial recruitment of mononuclear cells: exacerbation by inflammatory cytokines and amelioration by antioxidants. Cardiovasc Toxicol. 2004; 4(3):287-302. PMID: 15470276.
    Citations: 33     Fields:    Translation:HumansCells
  36. Pradhan L, Dabisch PA, Liles JT, Agrawal KC, Kadowitz PJ. Effect of acute intravenous cocaine administration on endothelium-dependent vasodepressor responses to acetylcholine. J Cardiovasc Pharmacol Ther. 2003 Mar; 8(1):43-51. PMID: 12652329.
    Citations:    Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.