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Rachael Ann Clark, Ph.D., M.D.


Identification of T cells specific for the Merkel cell polyomavirus in human Merkel cell carcinomas
Part Time, 08/30/10 - 06/30/11

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13AR079176 (CLARK, RACHAEL ANN) Jul 1, 2021 - Dec 31, 2022
    Skin Inflammation in Human Health and Disease, 2021
    Role: Principal Investigator
  2. U01CA253190 (CLARK, RACHAEL ANN) Sep 1, 2020 - May 31, 2025
    Optimizing pre-analytic sample handling for high throughput TCR sequencing in cutaneous T cell lymphoma
    Role: Principal Investigator
  3. U01AI148306 (CLARK, RACHAEL ANN) Feb 21, 2020 - Jan 31, 2025
    Using human skin grafted mice to identify biomarkers of exposure and study effects of radiation on skin
    Role: Principal Investigator
  4. R01AR074797 (CLARK, RACHAEL ANN) Sep 7, 2018 - Jul 31, 2022
    Reversing immune evasion and enhancing immune detection with topical resiquimod
    Role: Principal Investigator
  5. R13AR073669 (CLARK, RACHAEL ANN) May 1, 2018 - Apr 30, 2019
    Skin Inflammation in Human Health and Disease: 2018 International Conference
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Qiao J, Liu J, Jacobson JC, Clark RA, Lee S, Liu L, An Z, Zhang N, Chung DH. Anti-GRP-R monoclonal antibody antitumor therapy against neuroblastoma. PLoS One. 2022; 17(12):e0277956. PMID: 36525420; PMCID: PMC9757561.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Clark RA. Fishing with autoantibodies nets a gut bacteria that drives arthritis. Sci Immunol. 2022 12 09; 7(78):eadf9316. PMID: 36459567.
    Citations:    Fields:    Translation:AnimalsCells
  3. Clark RA. Gut check: Intestinal microbial diversity empowers lung immunity. Sci Immunol. 2022 07; 7(73):eadd6617. PMID: 35776803.
    Citations:    Fields:    Translation:Humans
  4. Giustiniani J, Dobos G, Moins-Teisserenc H, Eustaquio T, Battistella M, Ortonne N, Ram-Wolff C, Bouaziz JD, Marie-Cardine A, Mourah S, Bagot M, Kupper TS, Clark RA, Bensussan A, de Masson A. CCR8 is a new therapeutic target in cutaneous T-cell lymphomas. Blood Adv. 2022 06 14; 6(11):3507-3512. PMID: 35201316; PMCID: PMC9198911.
    Citations:    Fields:    Translation:Humans
  5. Weiner DM, Lewis DJ, Spaccarelli NG, Clark RA, Nasta SD, Loren AW, Rook AH, Kim EJ. Management of relapsed cutaneous T-Cell lymphoma following allogeneic hematopoietic stem cell transplantation: Review with representative patient case. Dermatol Ther. 2022 07; 35(7):e15538. PMID: 35477952.
    Citations:    Fields:    Translation:Humans
  6. Matos TR, Gehad A, Teague JE, Dyring-Andersen B, Benezeder T, Dowlatshahi M, Crouch J, Watanabe Y, O'Malley JT, Kupper TS, Yang C, Watanabe R, Clark RA. Central memory T cells are the most effective precursors of resident memory T cells in human skin. Sci Immunol. 2022 04 22; 7(70):eabn1889. PMID: 35452256; PMCID: PMC9435065.
    Citations:    Fields:    Translation:HumansAnimalsCells
  7. Borges TJ, Abarzua P, Gassen RB, Kollar B, Lima-Filho M, Aoyama BT, Gluhova D, Clark RA, Islam SA, Pomahac B, Murphy GF, Lian CG, Talbot SG, Riella LV. T cell-attracting CCL18 chemokine is a dominant rejection signal during limb transplantation. Cell Rep Med. 2022 03 15; 3(3):100559. PMID: 35492875; PMCID: PMC9040185.
    Citations:    Fields:    Translation:Humans
  8. van Santen S, Zoutman WH, de Masson A, Quint KD, Willemze R, Gerard N, Teague JE, Kupper TS, Clark RA, Tensen CP, Vermeer MH. Tumor Clone Frequency Calculation Using High-Throughput Sequencing of the TCRß Gene in Patients with Folliculotropic Mycosis Fungoides. J Invest Dermatol. 2022 09; 142(9):2544-2546.e2. PMID: 35304252.
    Citations:    Fields:    
  9. Yu KK, Smith NP, Essien SV, Teague JE, Vieyra-Garcia P, Gehad A, Zhan Q, Crouch JD, Gerard N, Larocca C, Wolf P, LeBoeuf NR, Tawa M, Kupper TS, Villani AC, Clark RA. IL-32 Supports the Survival of Malignant T Cells in Cutaneous T-cell Lymphoma. J Invest Dermatol. 2022 08; 142(8):2285-2288.e2. PMID: 35143819; PMCID: PMC9329172.
    Citations:    Fields:    Translation:HumansCells
  10. Clark RA. The trouble with TRIBbles: TRIB3 blocks CD8 T cell homing to colorectal cancers. Sci Immunol. 2022 02 04; 7(68):eabo2990. PMID: 35119938.
    Citations: 1     Fields:    Translation:HumansCells
  11. Chang MH, Levescot A, Nelson-Maney N, Blaustein RB, Winden KD, Morris A, Wactor A, Balu S, Grieshaber-Bouyer R, Wei K, Henderson LA, Iwakura Y, Clark RA, Rao DA, Fuhlbrigge RC, Nigrovic PA. Arthritis flares mediated by tissue-resident memory T cells in the joint. Cell Rep. 2021 10 26; 37(4):109902. PMID: 34706228; PMCID: PMC8561718.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  12. Vieyra-Garcia PA, Cerroni L, Clark RA, Wolf P. Lupus erythematosus tumidus in a patient with mycosis fungoides stage IB after complete response to PUVA. J Eur Acad Dermatol Venereol. 2021 Nov; 35(11):e758-e760. PMID: 34060127.
    Citations:    Fields:    Translation:Humans
  13. Cotton RN, Wegrecki M, Cheng TY, Chen YL, Veerapen N, Le Nours J, Orgill DP, Pomahac B, Talbot SG, Willis R, Altman JD, de Jong A, Van Rhijn I, Clark RA, Besra GS, Ogg G, Rossjohn J, Moody DB. CD1a selectively captures endogenous cellular lipids that broadly block T cell response. J Exp Med. 2021 07 05; 218(7). PMID: 33961028; PMCID: PMC8111460.
    Citations: 7     Fields:    Translation:HumansCells
  14. Win TS, Crisler WJ, Dyring-Andersen B, Lopdrup R, Teague JE, Zhan Q, Barrera V, Ho Sui S, Tasigiorgos S, Murakami N, Chandraker A, Tullius SG, Pomahac B, Riella LV, Clark RA. Immunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection. J Clin Invest. 2021 04 15; 131(8). PMID: 33667197; PMCID: PMC8262560.
    Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
  15. Benezeder T, Gehad A, Patra V, Clark R, Wolf P. Induction of IL-1ß and antimicrobial peptides as a potential mechanism for topical dithranol. Exp Dermatol. 2021 06; 30(6):841-846. PMID: 33629779; PMCID: PMC8247942.
    Citations:    Fields:    Translation:HumansAnimalsCells
  16. Sun Z, Kim JH, Kim SH, Kim HR, Zhang K, Pan Y, Ko MK, Kim BM, Chu H, Lee HR, Kim HL, Kim JH, Fu X, Hyun YM, Yun KN, Kim JY, Lee DW, Song SY, Lin CP, Clark RA, Lee KH, Kupper TS, Park CO. Skin-resident natural killer T cells participate in cutaneous allergic inflammation in atopic dermatitis. J Allergy Clin Immunol. 2021 05; 147(5):1764-1777. PMID: 33516870; PMCID: PMC9272812.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  17. Clark RA. Killing the buzz: NK cells in the aged brain. Sci Immunol. 2021 01 08; 6(55). PMID: 33419793.
    Citations:    Fields:    Translation:Cells
  18. Koguchi-Yoshioka H, Hoffer E, Cheuk S, Matsumura Y, Vo S, Kjellman P, Grema L, Ishitsuka Y, Nakamura Y, Okiyama N, Fujisawa Y, Fujimoto M, Eidsmo L, Clark RA, Watanabe R. Skin T cells maintain their diversity and functionality in the elderly. Commun Biol. 2021 01 04; 4(1):13. PMID: 33398080.
    Citations: 3     Translation:HumansCells
  19. Cotton RN, Cheng TY, Wegrecki M, Le Nours J, Orgill DP, Pomahac B, Talbot SG, Willis RA, Altman JD, de Jong A, Ogg G, Van Rhijn I, Rossjohn J, Clark RA, Moody DB. Human skin is colonized by T cells that recognize CD1a independently of lipid. J Clin Invest. 2021 01 04; 131(1). PMID: 33393500; PMCID: PMC7773353.
    Citations: 11     Fields:    Translation:HumansCells
  20. Durgin JS, Jariwala NN, Wysocka M, Zhang KK, Maity A, Benoit B, Plastaras JP, Lewis DJ, Rosenthal JM, Teague JE, Berg S, Del Guzzo C, Kim EJ, Vittorio C, Haun PL, Samimi SS, Villasenor-Park J, Inverso J, Clark RA, Rook AH. Low-Dose Total Skin Electron Beam Therapy as Part of a Multimodality Regimen for Treatment of Sézary Syndrome: Clinical, Immunologic, and Molecular Analysis. JAMA Dermatol. 2021 01 01; 157(1):90-95. PMID: 33112366; PMCID: PMC7593882.
    Citations: 1     Fields:    Translation:Humans
  21. Dyring-Andersen B, Løvendorf MB, Coscia F, Santos A, Møller LBP, Colaço AR, Niu L, Bzorek M, Doll S, Andersen JL, Clark RA, Skov L, Teunissen MBM, Mann M. Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin. Nat Commun. 2020 11 05; 11(1):5587. PMID: 33154365.
    Citations: 12     Fields:    Translation:HumansCells
  22. Divito SJ, Aasebø AT, Matos TR, Hsieh PC, Collin M, Elco CP, O'Malley JT, Bækkevold ES, Reims H, Gedde-Dahl T, Hagerstrom M, Hilaire J, Lian JW, Milford EL, Pinkus GS, Ho VT, Soiffer RJ, Kim HT, Mihm MC, Ritz J, Guleria I, Cutler CS, Clark RA, Jahnsen FL, Kupper TS. Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease. J Clin Invest. 2020 09 01; 130(9):4624-4636. PMID: 32516138; PMCID: PMC7456221.
    Citations: 17     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  23. Blümel E, Munir Ahmad S, Nastasi C, Willerslev-Olsen A, Gluud M, Fredholm S, Hu T, Surewaard BGJ, Lindahl LM, Fogh H, Koralov SB, Rahbek Gjerdrum LM, Clark RA, Iversen L, Krejsgaard T, Bonefeld CM, Geisler C, Becker JC, Woetmann A, Andersen MH, Buus TB, Ødum N. Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma. Oncoimmunology. 2020; 9(1):1751561. PMID: 32363124.
    Citations: 6     Fields:    Translation:HumansCells
  24. Pruessmann W, Rytlewski J, Wilmott J, Mihm MC, Attrill GH, Dyring-Andersen B, Fields P, Zhan Q, Colebatch AJ, Ferguson PM, Thompson JF, Kallenbach K, Yusko E, Clark RA, Robins H, Scolyer RA, Kupper TS. Publisher Correction: Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence. Nat Cancer. 2020 04; 1(4):470. PMID: 35121971.
  25. Clark RA. Kill shot: Flu vaccine is a stone cold cancer killer. Sci Immunol. 2020 Feb 07; 5(44). PMID: 32034087.
  26. Pruessmann W, Rytlewski J, Wilmott J, Mihm MC, Attrill GH, Dyring-Andersen B, Fields P, Zhan Q, Colebatch AJ, Ferguson PM, Thompson JF, Kallenbach K, Yusko E, Clark RA, Robins H, Scolyer RA, Kupper TS. Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence. Nat Cancer. 2020 02; 1(2):197-209. PMID: 33305293; PMCID: PMC7725220.
    Citations: 7     Translation:HumansCells
  27. O'Malley JT, de Masson A, Lowry EL, Giobbie-Hurder A, LeBoeuf NR, Larocca C, Gehad A, Seger E, Teague JE, Fisher DC, Kupper TS, Devlin PM, Clark RA. Radiotherapy Eradicates Malignant T Cells and Is Associated with Improved Survival in Early-Stage Mycosis Fungoides. Clin Cancer Res. 2020 01 15; 26(2):408-418. PMID: 31636100.
    Citations: 1     Fields:    Translation:HumansCells
  28. Clark RA. Changing of the guard. Sci Immunol. 2019 Sep 06; 4(39). PMID: 31492711.
  29. Vieyra-Garcia P, Fink-Puches R, Porkert S, Lang R, Pöchlauer S, Ratzinger G, Tanew A, Selhofer S, Paul-Gunther S, Hofer A, Gruber-Wackernagel A, Legat F, Patra V, Quehenberger F, Cerroni L, Clark R, Wolf P. Evaluation of Low-Dose, Low-Frequency Oral Psoralen-UV-A Treatment With or Without Maintenance on Early-Stage Mycosis Fungoides: A Randomized Clinical Trial. JAMA Dermatol. 2019 05 01; 155(5):538-547. PMID: 30892603; PMCID: PMC6506892.
    Citations: 10     Fields:    Translation:Humans
  30. Clark RA. Slamming the brakes on lupus with CAR T cells. Sci Immunol. 2019 04 05; 4(34). PMID: 30952806.
    Citations: 1     Fields:    
  31. O'Malley JT, Clark RA, Widlund HR. Skin Inflammation in Human Health and Disease: 2018 International Conference. J Invest Dermatol. 2019 05; 139(5):991-994. PMID: 30684557.
    Citations:    Fields:    Translation:Humans
  32. Vieyra-Garcia P, Crouch JD, O'Malley JT, Seger EW, Yang CH, Teague JE, Vromans AM, Gehad A, Win TS, Yu Z, Lowry EL, Na JI, Rook AH, Wolf P, Clark RA. Benign T cells drive clinical skin inflammation in cutaneous T cell lymphoma. JCI Insight. 2019 Jan 10; 4(1). PMID: 30626755; PMCID: PMC6485670.
    Citations: 19     Fields:    
  33. Clark RA. Harnessing TORC to boost the horsepower of aging immune systems. Sci Immunol. 2018 08 03; 3(26). PMID: 30076283.
    Citations:    Fields:    Translation:HumansCells
  34. Burton OT, Epp A, Fanny ME, Miller SJ, Stranks AJ, Teague JE, Clark RA, van de Rijn M, Oettgen HC. Tissue-Specific Expression of the Low-Affinity IgG Receptor, Fc?RIIb, on Human Mast Cells. Front Immunol. 2018; 9:1244. PMID: 29928276.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  35. de Masson A, O'Malley JT, Elco CP, Garcia SS, Divito SJ, Lowry EL, Tawa M, Fisher DC, Devlin PM, Teague JE, Leboeuf NR, Kirsch IR, Robins H, Clark RA, Kupper TS. High-throughput sequencing of the T cell receptor ß gene identifies aggressive early-stage mycosis fungoides. Sci Transl Med. 2018 05 09; 10(440). PMID: 29743350; PMCID: PMC6366329.
    Citations: 30     Fields:    Translation:HumansCells
  36. Clark RA. "That's not helping-T follicular helper cells drive skin fibrosis". Sci Immunol. 2018 04 06; 3(22). PMID: 29626172.
    Citations:    Fields:    Translation:HumansCells
  37. Gehad A, Teague JE, Matos TR, Huang V, Yang C, Watanabe R, O'Malley JT, Trimble CL, Kupper TS, Clark RA. A primary role for human central memory cells in tissue immunosurveillance. Blood Adv. 2018 02 13; 2(3):292-298. PMID: 29437556; PMCID: PMC5812324.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  38. Fallahian F, Molway D, Jadeja S, Clark R, Marty FM, Riella LV, Chandraker A, Talbot SG. Eponychial lesions following bilateral upper extremity vascular composite allotransplantation: a case report. Case Reports Plast Surg Hand Surg. 2018; 5(1):14-17. PMID: 29441355; PMCID: PMC5804719.
  39. Clark RA. Resident memory T cells: Runx and hide. Sci Immunol. 2018 01 05; 3(19). PMID: 29305464.
    Citations:    Fields:    Translation:Cells
  40. Park CO, Fu X, Jiang X, Pan Y, Teague JE, Collins N, Tian T, O'Malley JT, Emerson RO, Kim JH, Jung Y, Watanabe R, Fuhlbrigge RC, Carbone FR, Gebhardt T, Clark RA, Lin CP, Kupper TS. Staged development of long-lived T-cell receptor aß TH17 resident memory T-cell population to Candida albicans after skin infection. J Allergy Clin Immunol. 2018 08; 142(2):647-662. PMID: 29128674; PMCID: PMC5943196.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  41. Matos TR, O'Malley JT, Lowry EL, Hamm D, Kirsch IR, Robins HS, Kupper TS, Krueger JG, Clark RA. Clinically resolved psoriatic lesions contain psoriasis-specific IL-17-producing aß T cell clones. J Clin Invest. 2017 Nov 01; 127(11):4031-4041. PMID: 28945199; PMCID: PMC5663366.
    Citations: 75     Fields:    Translation:HumansCells
  42. Jain S, Washington A, Leaf RK, Bhargava P, Clark RA, Kupper TS, Stroopinsky D, Pyzer A, Cole L, Nahas M, Apel A, Rosenblatt J, Arnason J, Kufe D, Avigan D. Decitabine Priming Enhances Mucin 1 Inhibition Mediated Disruption of Redox Homeostasis in Cutaneous T-Cell Lymphoma. Mol Cancer Ther. 2017 10; 16(10):2304-2314. PMID: 28729399; PMCID: PMC5628140.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  43. Clark RA. Type I interference with self-tolerance. Sci Immunol. 2017 Jul 07; 2(13). PMID: 28783706.
    Citations:    Fields:    
  44. Win TS, Murakami N, Borges TJ, Chandraker A, Murphy G, Lian C, Barrera V, Ho Sui S, Schoenfeld D, Teague J, Bueno E, Tullius SG, Pomahac B, Clark RA, Riella LV. Longitudinal immunological characterization of the first presensitized recipient of a face transplant. JCI Insight. 2017 Jul 06; 2(13). PMID: 28679959.
    Citations: 2     Fields:    
  45. Clark RA. Barrier busting yeast brew trouble in the gut. Sci Immunol. 2017 Apr 07; 2(10). PMID: 28738019.
    Citations: 1     Fields:    
  46. Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA, Kupper TS. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. 2017 03 09; 543(7644):252-256. PMID: 28219080.
    Citations: 228     Fields:    Translation:HumansAnimalsCells
  47. Clark RA, Schlapbach C. TH9 cells in skin disorders. Semin Immunopathol. 2017 01; 39(1):47-54. PMID: 27896634.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  48. Clark SL, Tse JY, Fisher DC, LeBeouf NR, Murphy GF, Kupper TS, Clark RA, Lian CG. Histopathologic spectrum of hypersensitivity reactions associated with anti-CD52 therapy (alemtuzumab). J Cutan Pathol. 2016 Nov; 43(11):989-993. PMID: 27531597; PMCID: PMC5507594.
    Citations: 1     Fields:    Translation:Humans
  49. Mauldin IS, Wages NA, Stowman AM, Wang E, Olson WC, Deacon DH, Smith KT, Galeassi N, Teague JE, Smolkin ME, Chianese-Bullock KA, Clark RA, Petroni GR, Marincola FM, Mullins DW, Slingluff CL. Topical treatment of melanoma metastases with imiquimod, plus administration of a cancer vaccine, promotes immune signatures in the metastases. Cancer Immunol Immunother. 2016 10; 65(10):1201-12. PMID: 27522582; PMCID: PMC5037037.
    Citations: 19     Fields:    Translation:HumansCells
  50. Townsend EC, Murakami MA, Christodoulou A, Christie AL, Köster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC, Plana O, Montero J, Stevenson KE, Rao P, Vadhi R, Andreeff M, Armand P, Ballen KK, Barzaghi-Rinaudo P, Cahill S, Clark RA, Cooke VG, Davids MS, DeAngelo DJ, Dorfman DM, Eaton H, Ebert BL, Etchin J, Firestone B, Fisher DC, Freedman AS, Galinsky IA, Gao H, Garcia JS, Garnache-Ottou F, Graubert TA, Gutierrez A, Halilovic E, Harris MH, Herbert ZT, Horwitz SM, Inghirami G, Intlekofer AM, Ito M, Izraeli S, Jacobsen ED, Jacobson CA, Jeay S, Jeremias I, Kelliher MA, Koch R, Konopleva M, Kopp N, Kornblau SM, Kung AL, Kupper TS, LeBoeuf NR, LaCasce AS, Lees E, Li LS, Look AT, Murakami M, Muschen M, Neuberg D, Ng SY, Odejide OO, Orkin SH, Paquette RR, Place AE, Roderick JE, Ryan JA, Sallan SE, Shoji B, Silverman LB, Soiffer RJ, Steensma DP, Stegmaier K, Stone RM, Tamburini J, Thorner AR, van Hummelen P, Wadleigh M, Wiesmann M, Weng AP, Wuerthner JU, Williams DA, Wollison BM, Lane AA, Letai A, Bertagnolli MM, Ritz J, Brown M, Long H, Aster JC, Shipp MA, Griffin JD, Weinstock DM. The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 07 11; 30(1):183. PMID: 27479034.
    Citations: 26     Fields:    
  51. Townsend EC, Murakami MA, Christodoulou A, Christie AL, Köster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC, Plana O, Montero J, Stevenson KE, Rao P, Vadhi R, Andreeff M, Armand P, Ballen KK, Barzaghi-Rinaudo P, Cahill S, Clark RA, Cooke VG, Davids MS, DeAngelo DJ, Dorfman DM, Eaton H, Ebert BL, Etchin J, Firestone B, Fisher DC, Freedman AS, Galinsky IA, Gao H, Garcia JS, Garnache-Ottou F, Graubert TA, Gutierrez A, Halilovic E, Harris MH, Herbert ZT, Horwitz SM, Inghirami G, Intlekofer AM, Ito M, Izraeli S, Jacobsen ED, Jacobson CA, Jeay S, Jeremias I, Kelliher MA, Koch R, Konopleva M, Kopp N, Kornblau SM, Kung AL, Kupper TS, LeBoeuf NR, LaCasce AS, Lees E, Li LS, Look AT, Murakami M, Muschen M, Neuberg D, Ng SY, Odejide OO, Orkin SH, Paquette RR, Place AE, Roderick JE, Ryan JA, Sallan SE, Shoji B, Silverman LB, Soiffer RJ, Steensma DP, Stegmaier K, Stone RM, Tamburini J, Thorner AR, van Hummelen P, Wadleigh M, Wiesmann M, Weng AP, Wuerthner JU, Williams DA, Wollison BM, Lane AA, Letai A, Bertagnolli MM, Ritz J, Brown M, Long H, et al. The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 04 11; 29(4):574-586. PMID: 27070704; PMCID: PMC5177991.
    Citations: 114     Fields:    Translation:HumansAnimalsCells
  52. Kirsch IR, Watanabe R, O'Malley JT, Williamson DW, Scott LL, Elco CP, Teague JE, Gehad A, Lowry EL, LeBoeuf NR, Krueger JG, Robins HS, Kupper TS, Clark RA. TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL. Sci Transl Med. 2015 Oct 07; 7(308):308ra158. PMID: 26446955; PMCID: PMC4765389.
    Citations: 59     Fields:    Translation:HumansCells
  53. Rook AH, Gelfand JM, Gelfand JC, Wysocka M, Troxel AB, Benoit B, Surber C, Elenitsas R, Buchanan MA, Leahy DS, Watanabe R, Kirsch IR, Kim EJ, Clark RA. Topical resiquimod can induce disease regression and enhance T-cell effector functions in cutaneous T-cell lymphoma. Blood. 2015 Sep 17; 126(12):1452-61. PMID: 26228486; PMCID: PMC4573868.
    Citations: 60     Fields:    Translation:HumansCellsCTClinical Trials
  54. Jain S, Stroopinsky D, Yin L, Rosenblatt J, Alam M, Bhargava P, Clark RA, Kupper TS, Palmer K, Coll MD, Rajabi H, Pyzer A, Bar-Natan M, Luptakova K, Arnason J, Joyce R, Kufe D, Avigan D. Mucin 1 is a potential therapeutic target in cutaneous T-cell lymphoma. Blood. 2015 Jul 16; 126(3):354-62. PMID: 26048911; PMCID: PMC4504948.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  55. Gaide O, Emerson RO, Jiang X, Gulati N, Nizza S, Desmarais C, Robins H, Krueger JG, Clark RA, Kupper TS. Common clonal origin of central and resident memory T cells following skin immunization. Nat Med. 2015 Jun; 21(6):647-53. PMID: 25962122; PMCID: PMC4632197.
    Citations: 122     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  56. Watanabe R, Gehad A, Yang C, Scott LL, Teague JE, Schlapbach C, Elco CP, Huang V, Matos TR, Kupper TS, Clark RA. Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells. Sci Transl Med. 2015 Mar 18; 7(279):279ra39. PMID: 25787765; PMCID: PMC4425193.
    Citations: 216     Fields:    Translation:HumansAnimalsCells
  57. Guenova E, Skabytska Y, Hoetzenecker W, Weindl G, Sauer K, Tham M, Kim KW, Park JH, Seo JH, Ignatova D, Cozzio A, Levesque MP, Volz T, Köberle M, Kaesler S, Thomas P, Mailhammer R, Ghoreschi K, Schäkel K, Amarov B, Eichner M, Schaller M, Clark RA, Röcken M, Biedermann T. IL-4 abrogates T(H)17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2163-8. PMID: 25646481; PMCID: PMC4343151.
    Citations: 55     Fields:    Translation:HumansCells
  58. Clark RA. Resident memory T cells in human health and disease. Sci Transl Med. 2015 Jan 07; 7(269):269rv1. PMID: 25568072; PMCID: PMC4425129.
    Citations: 156     Fields:    Translation:HumansCells
  59. Watanabe R, Teague JE, Fisher DC, Kupper TS, Clark RA. Alemtuzumab therapy for leukemic cutaneous T-cell lymphoma: diffuse erythema as a positive predictor of complete remission. JAMA Dermatol. 2014 Jul; 150(7):776-9. PMID: 24760312; PMCID: PMC4092049.
    Citations: 8     Fields:    Translation:Humans
  60. Maldonado L, Teague JE, Morrow MP, Jotova I, Wu TC, Wang C, Desmarais C, Boyer JD, Tycko B, Robins HS, Clark RA, Trimble CL. Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions. Sci Transl Med. 2014 Jan 29; 6(221):221ra13. PMID: 24477000.
    Citations: 90     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  61. Schlapbach C, Gehad A, Yang C, Watanabe R, Guenova E, Teague JE, Campbell L, Yawalkar N, Kupper TS, Clark RA. Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity. Sci Transl Med. 2014 Jan 15; 6(219):219ra8. PMID: 24431112.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  62. Clark RA. Human skin in the game. Sci Transl Med. 2013 Sep 25; 5(204):204ps13. PMID: 24068735.
    Citations: 2     Fields:    Translation:HumansCells
  63. Guenova E, Watanabe R, Teague JE, Desimone JA, Jiang Y, Dowlatshahi M, Schlapbach C, Schaekel K, Rook AH, Tawa M, Fisher DC, Kupper TS, Clark RA. TH2 cytokines from malignant cells suppress TH1 responses and enforce a global TH2 bias in leukemic cutaneous T-cell lymphoma. Clin Cancer Res. 2013 Jul 15; 19(14):3755-63. PMID: 23785046.
    Citations: 69     Fields:    Translation:HumansCells
  64. Dowlatshahi M, Huang V, Gehad AE, Jiang Y, Calarese A, Teague JE, Dorosario AA, Cheng J, Nghiem P, Schanbacher CF, Thakuria M, Schmults CD, Wang LC, Clark RA. Tumor-specific T cells in human Merkel cell carcinomas: a possible role for Tregs and T-cell exhaustion in reducing T-cell responses. J Invest Dermatol. 2013 Jul; 133(7):1879-89. PMID: 23419694.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  65. Afanasiev OK, Nagase K, Simonson W, Vandeven N, Blom A, Koelle DM, Clark R, Nghiem P. Vascular E-selectin expression correlates with CD8 lymphocyte infiltration and improved outcome in Merkel cell carcinoma. J Invest Dermatol. 2013 Aug; 133(8):2065-73. PMID: 23353989.
    Citations: 26     Fields:    Translation:HumansCells
  66. Hijnen D, Knol EF, Gent YY, Giovannone B, Beijn SJ, Kupper TS, Bruijnzeel-Koomen CA, Clark RA. CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-?, IL-13, IL-17, and IL-22. J Invest Dermatol. 2013 Apr; 133(4):973-9. PMID: 23223131.
    Citations: 80     Fields:    Translation:HumansCells
  67. Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat Med. 2012 Aug; 18(8):1248-53. PMID: 22772464.
    Citations: 177     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  68. Gehad AE, Lichtman MK, Schmults CD, Teague JE, Calarese AW, Jiang Y, Watanabe R, Clark RA. Nitric oxide-producing myeloid-derived suppressor cells inhibit vascular E-selectin expression in human squamous cell carcinomas. J Invest Dermatol. 2012 Nov; 132(11):2642-51. PMID: 22718118.
    Citations: 29     Fields:    Translation:HumansCells
  69. Seneschal J, Clark RA, Gehad A, Baecher-Allan CM, Kupper TS. Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells. Immunity. 2012 May 25; 36(5):873-84. PMID: 22560445.
    Citations: 157     Fields:    Translation:HumansCells
  70. Cedeno-Laurent F, Watanabe R, Teague JE, Kupper TS, Clark RA, Dimitroff CJ. Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma. Blood. 2012 Apr 12; 119(15):3534-8. PMID: 22383798; PMCID: PMC3325040.
    Citations: 31     Fields:    Translation:HumansCells
  71. Jiang X, Clark RA, Liu L, Wagers AJ, Fuhlbrigge RC, Kupper TS. Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature. 2012 Feb 29; 483(7388):227-31. PMID: 22388819.
    Citations: 425     Fields:    Translation:AnimalsCells
  72. Clark RA, Watanabe R, Teague JE, Schlapbach C, Tawa MC, Adams N, Dorosario AA, Chaney KS, Cutler CS, Leboeuf NR, Carter JB, Fisher DC, Kupper TS. Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients. Sci Transl Med. 2012 Jan 18; 4(117):117ra7. PMID: 22261031.
    Citations: 138     Fields:    Translation:HumansCells
  73. Clark RA. Gone but not forgotten: lesional memory in psoriatic skin. J Invest Dermatol. 2011 Feb; 131(2):283-5. PMID: 21228808.
    Citations: 16     Fields:    Translation:HumansCells
  74. Purwar R, Campbell J, Murphy G, Richards WG, Clark RA, Kupper TS. Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity. PLoS One. 2011 Jan 26; 6(1):e16245. PMID: 21298112.
    Citations: 169     Fields:    Translation:HumansCells
  75. Clark RA, Shackelton JB, Watanabe R, Calarese A, Yamanaka K, Campbell JJ, Teague JE, Kuo HP, Hijnen D, Kupper TS. High-scatter T cells: a reliable biomarker for malignant T cells in cutaneous T-cell lymphoma. Blood. 2011 Feb 10; 117(6):1966-76. PMID: 21148332; PMCID: PMC3056643.
    Citations: 16     Fields:    Translation:HumansCells
  76. de Jong A, Peña-Cruz V, Cheng TY, Clark RA, Van Rhijn I, Moody DB. CD1a-autoreactive T cells are a normal component of the human aß T cell repertoire. Nat Immunol. 2010 Dec; 11(12):1102-9. PMID: 21037579.
    Citations: 137     Fields:    Translation:HumansCells
  77. Trimble CL, Clark RA, Thoburn C, Hanson NC, Tassello J, Frosina D, Kos F, Teague J, Jiang Y, Barat NC, Jungbluth AA. Human papillomavirus 16-associated cervical intraepithelial neoplasia in humans excludes CD8 T cells from dysplastic epithelium. J Immunol. 2010 Dec 01; 185(11):7107-14. PMID: 21037100; PMCID: PMC3075978.
    Citations: 58     Fields:    Translation:HumansCells
  78. Cedeno-Laurent F, Barthel SR, Opperman MJ, Lee DM, Clark RA, Dimitroff CJ. Development of a nascent galectin-1 chimeric molecule for studying the role of leukocyte galectin-1 ligands and immune disease modulation. J Immunol. 2010 Oct 15; 185(8):4659-72. PMID: 20844192; PMCID: PMC2953643.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  79. Campbell JJ, Clark RA, Watanabe R, Kupper TS. Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors. Blood. 2010 Aug 05; 116(5):767-71. PMID: 20484084; PMCID: PMC2918332.
    Citations: 139     Fields:    Translation:HumansCells
  80. van Geel NA, Mollet IG, De Schepper S, Tjin EP, Vermaelen K, Clark RA, Kupper TS, Luiten RM, Lambert J. First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi. Pigment Cell Melanoma Res. 2010 Jun; 23(3):375-84. PMID: 20370855.
    Citations: 13     Fields:    Translation:HumansCells
  81. Clark RA. Regulation gone wrong: a subset of Sézary patients have malignant regulatory T cells. J Invest Dermatol. 2009 Dec; 129(12):2747-50. PMID: 19901946.
    Citations: 4     Fields:    Translation:HumansCells
  82. Clark RA. Skin-resident T cells: the ups and downs of on site immunity. J Invest Dermatol. 2010 Feb; 130(2):362-70. PMID: 19675575.
    Citations: 109     Fields:    Translation:HumansAnimalsCells
  83. Clark RA, Fuhlbrigge RC. Immunology and skin disease 2009: frontiers in cutaneous immunology. J Invest Dermatol. 2009 Aug; 129(8):1849-51. PMID: 19603049.
    Citations:    Fields:    Translation:HumansAnimalsCells
  84. Huang SJ, Hijnen D, Murphy GF, Kupper TS, Calarese AW, Mollet IG, Schanbacher CF, Miller DM, Schmults CD, Clark RA. Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin. J Invest Dermatol. 2009 Nov; 129(11):2676-85. PMID: 19516264.
    Citations: 43     Fields:    Translation:HumansCells
  85. Clark RA, Huang SJ, Murphy GF, Mollet IG, Hijnen D, Muthukuru M, Schanbacher CF, Edwards V, Miller DM, Kim JE, Lambert J, Kupper TS. Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J Exp Med. 2008 Sep 29; 205(10):2221-34. PMID: 18794336.
    Citations: 87     Fields:    Translation:HumansCells
  86. Clark RA, Fuhlbrigge RC. Meeting report of immunology and skin disease: new perspectives. J Invest Dermatol. 2007 Aug; 127(8):1838-41. PMID: 17632556.
    Citations:    Fields:    Translation:HumansAnimalsCells
  87. Hirahara K, Liu L, Clark RA, Yamanaka K, Fuhlbrigge RC, Kupper TS. The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors. J Immunol. 2006 Oct 01; 177(7):4488-94. PMID: 16982885.
    Citations: 100     Fields:    Translation:HumansCells
  88. Clark RA, Kupper TS. IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood. 2007 Jan 01; 109(1):194-202. PMID: 16968902; PMCID: PMC1785078.
    Citations: 69     Fields:    Translation:HumansCells
  89. Clark RA, Kupper TS. Misbehaving macrophages in the pathogenesis of psoriasis. J Clin Invest. 2006 Aug; 116(8):2084-7. PMID: 16886055; PMCID: PMC1523394.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  90. Clark RA, Chong BF, Mirchandani N, Yamanaka K, Murphy GF, Dowgiert RK, Kupper TS. A novel method for the isolation of skin resident T cells from normal and diseased human skin. J Invest Dermatol. 2006 May; 126(5):1059-70. PMID: 16484986.
    Citations: 74     Fields:    Translation:HumansCells
  91. Clark RA, Chong B, Mirchandani N, Brinster NK, Yamanaka K, Dowgiert RK, Kupper TS. The vast majority of CLA+ T cells are resident in normal skin. J Immunol. 2006 Apr 01; 176(7):4431-9. PMID: 16547281.
    Citations: 298     Fields:    Translation:HumansCells
  92. Yamanaka K, Clark R, Dowgiert R, Hurwitz D, Shibata M, Rich BE, Hirahara K, Jones DA, Eapen S, Mizutani H, Kupper TS. Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma. Clin Cancer Res. 2006 Jan 15; 12(2):376-82. PMID: 16428475.
    Citations: 15     Fields:    Translation:HumansCells
  93. Clark, R. A., B. F. Chong, N. Mirchandani, N. Brinster, K. Yamanaka, R. Dowgiert, and T. S. Kupper. . The vast majority of CLA+ T cells are resident in normal skin. Journal of Immunology. 2006; 176(7):4431-9.
  94. Yamanaka, K., Clark, R., Dowgiert, R., Hurwitz, D., Shibata, M., Rich, B., Hirahara, K., Jones, D., Eapen, S., and Kupper, TS. Expression of interleukin-18 and caspase-1 in cutaneous T cell lymphoma. Clincal Cancer Research. 2006; 12(2):376-82.
  95. Clark, RA, Murphy, G.F., Schanbacher, C.F. and Kupper, T.S. . Downregulation of E-selectin on squamous cell carcinoma vasculature: immune evasion and its reversal by imiquimod therapy. 2006 Meeting of the Society for Investigative Dermatology. J Invest Derm. 2006.
  96. Clark, RA and Kupper, TS. . Dermal fibroblasts and IL-15 induce the proliferation of natural regulatory T cells isolated from human skin. 2006 Meeting of the Society for Investigative Dermatology. J Invest Derm. 2006.
  97. Yamanaka K, Clark R, Rich B, Dowgiert R, Hirahara K, Hurwitz D, Shibata M, Mirchandani N, Jones DA, Goddard DS, Eapen S, Mizutani H, Kupper TS. Skin-derived interleukin-7 contributes to the proliferation of lymphocytes in cutaneous T-cell lymphoma. Blood. 2006 Mar 15; 107(6):2440-5. PMID: 16322477; PMCID: PMC1895734.
    Citations: 26     Fields:    Translation:HumansCells
  98. Clark RA, Yamanaka K, Bai M, Dowgiert R, Kupper TS. Human skin cells support thymus-independent T cell development. J Clin Invest. 2005 Nov; 115(11):3239-49. PMID: 16224538; PMCID: PMC1253623.
    Citations: 28     Fields:    Translation:HumansCells
  99. Clark R, Kupper T. Old meets new: the interaction between innate and adaptive immunity. J Invest Dermatol. 2005 Oct; 125(4):629-37. PMID: 16185260.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  100. Clark, RA. Process for Producing T lymphocytes US patent application, filed Dec 2005. . 2005.
  101. Formica M, Kabbara K, Clark R, McAlindon T. Can clinical trials requiring frequent participant contact be conducted over the Internet? Results from an online randomized controlled trial evaluating a topical ointment for herpes labialis. J Med Internet Res. 2004 Feb 17; 6(1):e6. PMID: 15111272; PMCID: PMC1550589.
    Citations: 13     Fields:    Translation:HumansCTClinical Trials
  102. Clark, RA, Fuhlbrigge RC, Springer, TA. . L-selectin ligands presented by non-mucin molecules are sufficient for tethering and rolling of lymphocytes on human HEV. Journal of Cell Biology. 1998; 140(3):721-31.
  103. Clark, RA, Springer, TA. . CD90 Cluster Report. Leukocyte Typing VI: White Cell Differentiation Antigens. 1998.
  104. Clark, RA, Springer, TA. . The Sixth International Workshop on Human Leukocyte Antigens CD Guide for CD90. CD Guides. 1998.
  105. Clark RA, Erickson HP, Springer TA. Tenascin supports lymphocyte rolling. J Cell Biol. 1997 May 05; 137(3):755-65. PMID: 9151679; PMCID: PMC2139881.
    Citations: 17     Fields:    Translation:HumansCells
  106. Clark RA, Alon R, Springer TA. CD44 and hyaluronan-dependent rolling interactions of lymphocytes on tonsillar stroma. J Cell Biol. 1996 Aug; 134(4):1075-87. PMID: 8769428; PMCID: PMC2120952.
    Citations: 41     Fields:    Translation:HumansCells
  107. Clark, RA. . Lymphocyte trafficking: Adhesive interactions in secondary lymphoid organs [dissertation]. 1996.
  108. Clark, RA, Fuhlbrigge, RC, Lowe, JB, Springer, TA. . Tissue distribution of fucosyl transferases by immunohistochemistry. FASEB Journal. 1995; 9(4):A794.
  109. Clark RA, Watanabe AT, Bradley WG, Roberts JD. Acute hematomas: effects of deoxygenation, hematocrit, and fibrin-clot formation and retraction on T2 shortening. Radiology. 1990 Apr; 175(1):201-6. PMID: 2315481.
    Citations: 19     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.