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profileRichard Neal Mitchell, M.D., Ph.D.

TitleProfessor of Pathology and Health Sciences and Technology
InstitutionBrigham and Women's Hospital
DepartmentPathology
AddressBrigham and Women
NRB Rm. 730D
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/525-4303
Fax617/525-4329
vCardDownload vCard (login for email)
Other Positions
TitleAssociate Director of Longwood Society and Advosors
InstitutionMassachusetts Institute of Technology
DepartmentHealth Sciences and Technology


Collapse Mentoring 
Collapse current student opportunities
Available: 08/11/17, Expires: 06/28/19

The fundamental hypothesis is that a well-done autopsy more often than not "stops" a malpractice suit from going forward. In other words, autopsies end up being a cost-effective mechanism for protecting physicians overall, and in keeping the bottom line of the hospital more robust. The project will test whether autopsies are superior/inferior/equivalent to non-autopsied deaths in affecting the rate and success of lawsuits. This would be part of a larger study to look at the rates of "missed" diagnoses found unexpectedly at autopsy, and quantifying whether they would have impacted patient care and/or outcomes. The hypothesis is that the numbers have not changed dramatically since the study published in 1983:

The value of the autopsy in three medical eras. Goldman L, Sayson R, Robbins S, Cohn LH, Bettmann M, Weisberg M. N Engl J Med. 1983 Apr 28;308(17):1000-5

The student will participate in all aspects of the study including data collation and analysis.

Collapse completed student projects
Selective Corneal Cross-Linking with use of Two-Photon Photochemical Activation
Summer, 05/28/13 - 09/03/13
Functional Characterization of a Novel Genetic Locus for Plasma Cholesterol
Summer, 01/07/13 - 01/31/14
The Determinants and Mechanism of B-ALL Entry to the CNS
Summer, 06/01/11 - 08/26/11
Assessment of Breast Cancer Risk Models in U.S. Populations
Summer, 06/16/14 - 09/01/14
Immunogenicity of Valvular Endothelium
Summer, 05/19/00 - 08/01/00
Characterization of the CD8 T Cell Response to MHV-68 Infection
Summer, 06/02/08 - 08/29/08
ENFDO CHEMOKIES IN TXAA
Summer, 07/01/03 - 08/31/03
Autologous cell-based high precision, closed-loop, optically-controlled insulin delivery
Summer, 05/28/09 - 08/28/09
Pathways of MHCII-dependent Antigen Presentation in B Cells
Summer, 05/24/99 - 08/27/99
Primary Mouth Development
Summer, 06/01/09 - 08/31/09
Clinical elective in internal medicine at McCord Hospital, Durban, South Africa
International, 01/30/06 - 02/24/06
International Clinical Elective - PUMC, China, Spring 2011
International, 02/28/11 - 04/22/11
Detecting inflammation: E. coli sensors of reactive oxygen species
Full Time, 05/31/12 - 08/31/12
Single Chromosome Amplification
Summer, 03/01/06 - 06/01/08
CA4+: a novel cationic contrast agent for evaluating glycosaminoglycan content by CT imaging
Part Time, 01/02/11 - 05/30/13
Molecular and cellular analysis of structural plasticity in the adult cortex of Par-4 mice
Summer, 06/01/07 - 08/31/07
Basement Membrane Regulation in the Primary Mouth Region
Summer, 07/14/10 - 09/01/10
Influence of metabolic regulation on primary cell proliferation and differentiation
Summer, 06/01/12 - 09/01/12

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R13CA217139     (MITCHELL, RICHARD N)Apr 20, 2017 - Apr 19, 2018
NIH/NCI
2017 Annual Meeting of the American Society for Investigative Pathology
Role: Principal Investigator

R01GM067049     (MITCHELL, RICHARD N)Mar 1, 2003 - Feb 28, 2007
NIH/NIGMS
Origin of Intimal cells in allograft arteriopathy
Role: Principal Investigator

R01GM047726     (MITCHELL, RICHARD N)Apr 1, 1992 - Mar 31, 2001
NIH/NIGMS
MEMBRANE RECEPTOR TRAFFICKING AND ANTIGEN PROCESSING
Role: Principal Investigator

R01HL043364     (MITCHELL, RICHARD N)Apr 1, 1990 - Sep 30, 2004
NIH/NHLBI
PATHOGENESIS OF TRANSPLANT ASSOCIATED ARTERIOSCLEROSIS
Role: Principal Investigator

T32HL007627     (MITCHELL, RICHARD N)Jul 1, 1985 - Jun 30, 2020
NIH/NHLBI
Vascular, Pulmonary and Renal Injury
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Minhas PS, Enogieru IE, Mitchell RN, Mata DA. Passport to pathology: transforming the medical student pathology elective from a passive educational experience to an exciting, immersive clinical rotation. Hum Pathol. 2017 Oct; 68:34-39. PMID: 28893532.
    View in: PubMed
  2. Chu Y, Mitchell RN, Mata DA. Improving undergraduate pathology teaching: medical students' perspective-reply. Hum Pathol. 2017 Oct; 68:203-204. PMID: 28890339.
    View in: PubMed
  3. Glass CK, Mitchell RN. Winning the battle, but losing the war: mechanisms and morphology of cancer-therapy-associated cardiovascular toxicity. Cardiovasc Pathol. 2017 Sep - Oct; 30:55-63. PMID: 28759820.
    View in: PubMed
  4. DeFilippis EM, Cuddy S, Glass C, Priya S, Aghayev A, Mitchell RN, Marty FM, DiCarli MF, Blankstein R. Use of Multimodality Imaging in Diagnosing Invasive Fungal Diseases of the Heart. Circ Cardiovasc Imaging. 2017 Jun; 10(6). PMID: 28576787.
    View in: PubMed
  5. Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M. Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017 Apr 20; 169(3):510-522.e20. PMID: 28431249.
    View in: PubMed
  6. Badr Eslam R, Croce K, Mangione FM, Musmann R, Leopold JA, Mitchell RN, Waxman AB. Persistence and proliferation of human mesenchymal stromal cells in the right ventricular myocardium after intracoronary injection in a large animal model of pulmonary hypertension. Cytotherapy. 2017 Jun; 19(6):668-679. PMID: 28392314.
    View in: PubMed
  7. Thomas R, Glass C, Mitchell RN, Steigner ML, Aghayev A. Giant cell aortitis mimicking intramural hematoma. J Cardiovasc Comput Tomogr. 2017 Jul - Aug; 11(4):327-328. PMID: 28196684.
    View in: PubMed
  8. Mangione FM, Jatene T, Gonçalves A, Fishbein GA, Mitchell RN, Pelletier MP, Kaneko T, Shah PB, Nyman CB, Shook D, Blankstein R, Padera RF, Bhatt DL. Leaflet Thrombosis in Surgically Explanted or Post-Mortem TAVR Valves. JACC Cardiovasc Imaging. 2017 Jan; 10(1):82-85. PMID: 28057222.
    View in: PubMed
  9. Farhad H, Staziaki PV, Addison D, Coelho-Filho OR, Shah RV, Mitchell RN, Szilveszter B, Abbasi SA, Kwong RY, Scherrer-Crosbie M, Hoffmann U, Jerosch-Herold M, Neilan TG. Characterization of the Changes in Cardiac Structure and Function in Mice Treated With Anthracyclines Using Serial Cardiac Magnetic Resonance Imaging. Circ Cardiovasc Imaging. 2016 Dec; 9(12). PMID: 27923796.
    View in: PubMed
  10. Halushka MK, Mitchell RN, Padera RF. Heart failure therapies: new strategies for old treatments and new treatments for old strategies. Cardiovasc Pathol. 2016 Nov - Dec; 25(6):503-511. PMID: 27619734.
    View in: PubMed
  11. Mahadevan NR, Morgan EA, Mitchell RN. Case report and literature review: cardiac tamponade as a complication of pericardial extramedullary hematopoiesis. Cardiovasc Pathol. 2016 Sep-Oct; 25(5):371-4. PMID: 27288747.
    View in: PubMed
  12. Halushka MK, Angelini A, Bartoloni G, Basso C, Batoroeva L, Bruneval P, Buja LM, Butany J, d'Amati G, Fallon JT, Gallagher PJ, Gittenberger-de Groot AC, Gouveia RH, Kholova I, Kelly KL, Leone O, Litovsky SH, Maleszewski JJ, Miller DV, Mitchell RN, Preston SD, Pucci A, Radio SJ, Rodriguez ER, Sheppard MN, Stone JR, Suvarna SK, Tan CD, Thiene G, Veinot JP, van der Wal AC. Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association For European Cardiovascular Pathology: II. Noninflammatory degenerative diseases - nomenclature and diagnostic criteria. Cardiovasc Pathol. 2016 May-Jun; 25(3):247-57. PMID: 27031798.
    View in: PubMed
  13. Chu Y, Mitchell RN, Mata DA. Using exit competencies to integrate pathology into the undergraduate clinical clerkships. Hum Pathol. 2016 Jan; 47(1):1-3. PMID: 26482607.
    View in: PubMed
  14. Torre M, Hwang DH, Padera RF, Mitchell RN, VanderLaan PA. Osseous and chondromatous metaplasia in calcific aortic valve stenosis. Cardiovasc Pathol. 2016 Jan-Feb; 25(1):18-24. PMID: 26386747.
    View in: PubMed
  15. Stone JR, Bruneval P, Angelini A, Bartoloni G, Basso C, Batoroeva L, Buja LM, Butany J, d'Amati G, Fallon JT, Gittenberger-de Groot AC, Gouveia RH, Halushka MK, Kelly KL, Kholova I, Leone O, Litovsky SH, Maleszewski JJ, Miller DV, Mitchell RN, Preston SD, Pucci A, Radio SJ, Rodriguez ER, Sheppard MN, Suvarna SK, Tan CD, Thiene G, van der Wal AC, Veinot JP. Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology: I. Inflammatory diseases. Cardiovasc Pathol. 2015 Sep-Oct; 24(5):267-78. PMID: 26051917.
    View in: PubMed
  16. Coelho-Filho OR, Shah RV, Neilan TG, Mitchell R, Moreno H, Kwong R, Jerosch-Herold M. Cardiac magnetic resonance assessment of interstitial myocardial fibrosis and cardiomyocyte hypertrophy in hypertensive mice treated with spironolactone. J Am Heart Assoc. 2014 Jun 25; 3(3):e000790. PMID: 24965024; PMCID: PMC4309062.
  17. Zhang C, Jang S, Amadi OC, Shimizu K, Lee RT, Mitchell RN. A sensitive chemotaxis assay using a novel microfluidic device. Biomed Res Int. 2013; 2013:373569. PMID: 24151597; PMCID: PMC3787577.
  18. Coelho-Filho OR, Shah RV, Mitchell R, Neilan TG, Moreno H, Simonson B, Kwong R, Rosenzweig A, Das S, Jerosch-Herold M. Quantification of cardiomyocyte hypertrophy by cardiac magnetic resonance: implications for early cardiac remodeling. Circulation. 2013 Sep 10; 128(11):1225-33. PMID: 23912910.
    View in: PubMed
  19. Nelson KH, Chatzizisis YS, Steigner ML, Mitchell RN, Blankstein R, Givertz MM. Cardiac allograft involvement by post-transplantation lymphoproliferative disorder. J Am Coll Cardiol. 2013 Sep 03; 62(10):937. PMID: 23850919.
    View in: PubMed
  20. Mitchell RN. Learning from rejection: what transplantation teaches us about (other) vascular pathologies. J Autoimmun. 2013 Sep; 45:80-9. PMID: 23830871.
    View in: PubMed
  21. Welt FG, Gallegos R, Connell J, Kajstura J, D'Amario D, Kwong RY, Coelho-Filho O, Shah R, Mitchell R, Leri A, Foley L, Anversa P, Pfeffer MA. Effect of cardiac stem cells on left-ventricular remodeling in a canine model of chronic myocardial infarction. Circ Heart Fail. 2013 Jan; 6(1):99-106. PMID: 23212553.
    View in: PubMed
  22. Coelho-Filho OR, Mongeon FP, Mitchell R, Moreno H, Nadruz W, Kwong R, Jerosch-Herold M. Role of transcytolemmal water-exchange in magnetic resonance measurements of diffuse myocardial fibrosis in hypertensive heart disease. Circ Cardiovasc Imaging. 2013 Jan 01; 6(1):134-41. PMID: 23159497; PMCID: PMC3587170.
  23. Seidman MA, Mitchell RN. Surgical Pathology of Small- and Medium-Sized Vessels. Surg Pathol Clin. 2012 Jun; 5(2):435-51. PMID: 26838112.
    View in: PubMed
  24. Furie MB, Mitchell RN. Plaque attack: one hundred years of atherosclerosis in The American Journal of Pathology. Am J Pathol. 2012 Jun; 180(6):2184-7. PMID: 22551843.
    View in: PubMed
  25. Herman DS, Lam L, Taylor MR, Wang L, Teekakirikul P, Christodoulou D, Conner L, DePalma SR, McDonough B, Sparks E, Teodorescu DL, Cirino AL, Banner NR, Pennell DJ, Graw S, Merlo M, Di Lenarda A, Sinagra G, Bos JM, Ackerman MJ, Mitchell RN, Murry CE, Lakdawala NK, Ho CY, Barton PJ, Cook SA, Mestroni L, Seidman JG, Seidman CE. Truncations of titin causing dilated cardiomyopathy. N Engl J Med. 2012 Feb 16; 366(7):619-28. PMID: 22335739; PMCID: PMC3660031.
  26. Shimizu K, Libby P, Rocha VZ, Folco EJ, Shubiki R, Grabie N, Jang S, Lichtman AH, Shimizu A, Hogg N, Simon DI, Mitchell RN, Croce K. Loss of myeloid related protein-8/14 exacerbates cardiac allograft rejection. Circulation. 2011 Dec 20; 124(25):2920-32. PMID: 22144572; PMCID: PMC3277828.
  27. D'Amario D, Fiorini C, Campbell PM, Goichberg P, Sanada F, Zheng H, Hosoda T, Rota M, Connell JM, Gallegos RP, Welt FG, Givertz MM, Mitchell RN, Leri A, Kajstura J, Pfeffer MA, Anversa P. Functionally competent cardiac stem cells can be isolated from endomyocardial biopsies of patients with advanced cardiomyopathies. Circ Res. 2011 Apr 01; 108(7):857-61. PMID: 21330601; PMCID: PMC3074470.
  28. Coelho-Filho OR, Mongeon FP, Mitchell RN, Blankstein R, Jerosch-Herold M, Kwong RY. Images in cardiovascular medicine. Löffler endocarditis presenting with recurrent polymorphic ventricular tachycardia diagnosed by cardiac magnetic resonance imaging. Circulation. 2010 Jul 06; 122(1):96-9. PMID: 20606132.
    View in: PubMed
  29. Steven D, Roberts-Thomson KC, Seiler J, Inada K, Tedrow UB, Mitchell RN, Sobieszczyk PS, Eisenhauer AC, Couper GS, Stevenson WG. Ventricular tachycardia arising from the aortomitral continuity in structural heart disease: characteristics and therapeutic considerations for an anatomically challenging area of origin. Circ Arrhythm Electrophysiol. 2009 Dec; 2(6):660-6. PMID: 20009078.
    View in: PubMed
  30. Shimizu K, Minami M, Shubiki R, Lopez-Ilasaca M, MacFarlane L, Asami Y, Li Y, Mitchell RN, Libby P. CC chemokine receptor-1 activates intimal smooth muscle-like cells in graft arterial disease. Circulation. 2009 Nov 03; 120(18):1800-13. PMID: 19841301; PMCID: PMC2996873.
  31. Okamoto Y, Christen T, Shimizu K, Asano K, Kihara S, Mitchell RN, Libby P. Adiponectin inhibits allograft rejection in murine cardiac transplantation. Transplantation. 2009 Oct 15; 88(7):879-83. PMID: 19935458; PMCID: PMC2784664.
  32. Mitchell RN. Graft vascular disease: immune response meets the vessel wall. Annu Rev Pathol. 2009; 4:19-47. PMID: 18717641.
    View in: PubMed
  33. Shimizu K, Mitchell RN. The role of chemokines in transplant graft arterial disease. Arterioscler Thromb Vasc Biol. 2008 Nov; 28(11):1937-49. PMID: 18802020.
    View in: PubMed
  34. Shimizu K, Libby P, Shubiki R, Sakuma M, Wang Y, Asano K, Mitchell RN, Simon DI. Leukocyte integrin Mac-1 promotes acute cardiac allograft rejection. Circulation. 2008 Apr 15; 117(15):1997-2008. PMID: 18378617; PMCID: PMC2495049.
  35. Duan X, Yarmush D, Leeder A, Yarmush ML, Mitchell RN. Burn-induced immunosuppression: attenuated T cell signaling independent of IFN-gamma- and nitric oxide-mediated pathways. J Leukoc Biol. 2008 Feb; 83(2):305-13. PMID: 18024716.
    View in: PubMed
  36. Mitchell RN, Libby P. Vascular remodeling in transplant vasculopathy. Circ Res. 2007 Apr 13; 100(7):967-78. PMID: 17431198.
    View in: PubMed
  37. Song L, DePalma SR, Kharlap M, Zenovich AG, Cirino A, Mitchell R, McDonough B, Maron BJ, Seidman CE, Seidman JG, Ho CY. Novel locus for an inherited cardiomyopathy maps to chromosome 7. Circulation. 2006 May 09; 113(18):2186-92. PMID: 16651466.
    View in: PubMed
  38. Shimizu K, Mitchell RN, Libby P. Inflammation and cellular immune responses in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol. 2006 May; 26(5):987-94. PMID: 16497993.
    View in: PubMed
  39. Taqueti VR, Mitchell RN, Lichtman AH. Protecting the pump: controlling myocardial inflammatory responses. Annu Rev Physiol. 2006; 68:67-95. PMID: 16460267.
    View in: PubMed
  40. Sugiyama S, Kugiyama K, Nakamura S, Kataoka K, Aikawa M, Shimizu K, Koide S, Mitchell RN, Ogawa H, Libby P. Characterization of smooth muscle-like cells in circulating human peripheral blood. Atherosclerosis. 2006 Aug; 187(2):351-62. PMID: 16253262.
    View in: PubMed
  41. Monahan TS, Phaneuf MD, Contreras MA, Andersen ND, Popescu-Vladimir A, Bide MJ, Dempsey DJ, Mitchell RN, Hamdan AD, LoGerfo FW. In vivo testing of an infection-resistant annuloplasty ring. J Surg Res. 2006 Jan; 130(1):140-5. PMID: 16154148.
    View in: PubMed
  42. Shah RV, Mitchell RN. The role of stem cells in the response to myocardial and vascular wall injury. Cardiovasc Pathol. 2005 Sep-Oct; 14(5):225-31. PMID: 16168894.
    View in: PubMed
  43. Lee CW, Mitchell RN, Horan RF, Castells MC. Cardiogenic shock and peripheral eosinophilia in a young woman. Ann Allergy Asthma Immunol. 2005 Sep; 95(3):229-33. PMID: 16200812.
    View in: PubMed
  44. Batirel HF, Batirel S, Mitchell RN, Swanson SJ. Interferon-gamma knockout fails to confer protection against obliteration in heterotopic murine tracheal allografts. J Heart Lung Transplant. 2005 Jun; 24(6):658-64. PMID: 15949724.
    View in: PubMed
  45. Shimizu K, Libby P, Mitchell RN. Local cytokine environments drive aneurysm formation in allografted aortas. Trends Cardiovasc Med. 2005 May; 15(4):142-8. PMID: 16099378.
    View in: PubMed
  46. Binello E, Mitchell RN, Harling OK. T cell uptake for the use of boron neutron capture as an immunologic research tool. Appl Radiat Isot. 2004 Nov; 61(5):959-62. PMID: 15308175.
    View in: PubMed
  47. Mitchell RN, Lichtman AH. The link between IFN-gamma and allograft arteriopathy: is the answer NO? J Clin Invest. 2004 Sep; 114(6):762-4. PMID: 15372099; PMCID: PMC516268.
  48. Furukawa Y, Cole SE, Shah RV, Fukumoto Y, Libby P, Mitchell RN. Wild-type but not interferon-gamma-deficient T cells induce graft arterial disease in the absence of B cells. Cardiovasc Res. 2004 Aug 01; 63(2):347-56. PMID: 15249193.
    View in: PubMed
  49. Shimizu K, Shichiri M, Libby P, Lee RT, Mitchell RN. Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas. J Clin Invest. 2004 Jul; 114(2):300-8. PMID: 15254597; PMCID: PMC449742.
  50. Feinberg MW, Shimizu K, Lebedeva M, Haspel R, Takayama K, Chen Z, Frederick JP, Wang XF, Simon DI, Libby P, Mitchell RN, Jain MK. Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation. Circ Res. 2004 Mar 19; 94(5):601-8. PMID: 14752027.
    View in: PubMed
  51. Mitchell RN. Allograft arteriopathy: pathogenesis update. Cardiovasc Pathol. 2004 Jan-Feb; 13(1):33-40. PMID: 14761783.
    View in: PubMed
  52. Shimizu K, Aikawa M, Takayama K, Libby P, Mitchell RN. Direct anti-inflammatory mechanisms contribute to attenuation of experimental allograft arteriosclerosis by statins. Circulation. 2003 Oct 28; 108(17):2113-20. PMID: 14517172.
    View in: PubMed
  53. Suzuki J, Cole SE, Batirel S, Kosuge H, Shimizu K, Isobe M, Libby P, Mitchell RN. Tumor necrosis factor receptor -1 and -2 double deficiency reduces graft arterial disease in murine cardiac allografts. Am J Transplant. 2003 Aug; 3(8):968-76. PMID: 12859531.
    View in: PubMed
  54. Shimizu K, Mitchell RN. Stem cell origins of intimal cells in graft arterial disease. Curr Atheroscler Rep. 2003 May; 5(3):230-7. PMID: 12667437.
    View in: PubMed
  55. Sayegh MH, Wu Z, Hancock WW, Langmuir PB, Mata M, Sandner S, Kishimoto K, Sho M, Palmer E, Mitchell RN, Turka LA. Allograft rejection in a new allospecific CD4+ TCR transgenic mouse. Am J Transplant. 2003 Apr; 3(4):381-9. PMID: 12694059.
    View in: PubMed
  56. Madibally SV, Solomon V, Mitchell RN, Van De Water L, Yarmush ML, Toner M. Influence of insulin therapy on burn wound healing in rats. J Surg Res. 2003 Feb; 109(2):92-100. PMID: 12643849.
    View in: PubMed
  57. Madihally SV, Toner M, Yarmush ML, Mitchell RN. Interferon gamma modulates trauma-induced muscle wasting and immune dysfunction. Ann Surg. 2002 Nov; 236(5):649-57. PMID: 12409672; PMCID: PMC1422624.
  58. Zhao DX, Hu Y, Miller GG, Luster AD, Mitchell RN, Libby P. Differential expression of the IFN-gamma-inducible CXCR3-binding chemokines, IFN-inducible protein 10, monokine induced by IFN, and IFN-inducible T cell alpha chemoattractant in human cardiac allografts: association with cardiac allograft vasculopathy and acute rejection. J Immunol. 2002 Aug 01; 169(3):1556-60. PMID: 12133984.
    View in: PubMed
  59. Solomon V, Madihally S, Mitchell RN, Yarmush M, Toner M. Antiproteolytic action of insulin in burn-injured rats. J Surg Res. 2002 Jun 15; 105(2):234-42. PMID: 12121712.
    View in: PubMed
  60. Nashar TO, Betteridge ZE, Mitchell RN. Antigen binding to GM1 ganglioside results in delayed presentation: minimal effects of GM1 on presentation of antigens internalized via other pathways. Immunology. 2002 May; 106(1):60-70. PMID: 11972633; PMCID: PMC1782691.
  61. Halamay KE, Kirkman RL, Sun L, Yamada A, Fragoso RC, Shimizu K, Mitchell RN, McKay DB. CD8 T cells are sufficient to mediate allorecognition and allograft rejection. Cell Immunol. 2002 Mar-Apr; 216(1-2):6-14. PMID: 12381345.
    View in: PubMed
  62. Furukawa Y, Libby P, Stinn JL, Becker G, Mitchell RN. Cold ischemia induces isograft arteriopathy, but does not augment allograft arteriopathy in non-immunosuppressed hosts. Am J Pathol. 2002 Mar; 160(3):1077-87. PMID: 11891204; PMCID: PMC1867181.
  63. Mitchell RN. Don't blame the lymphocyte: immunologic processes are NOT important in tissue valve failure. J Heart Valve Dis. 2001 Jul; 10(4):467-70. PMID: 11499592.
    View in: PubMed
  64. Shimizu K, Sugiyama S, Aikawa M, Fukumoto Y, Rabkin E, Libby P, Mitchell RN. Host bone-marrow cells are a source of donor intimal smooth- muscle-like cells in murine aortic transplant arteriopathy. Nat Med. 2001 Jun; 7(6):738-41. PMID: 11385513.
    View in: PubMed
  65. Kadner A, Chen RH, Mitchell RN, Adams DH. Hemograft crossmatching is unnecessary due to the absence of blood group antigens. Ann Thorac Surg. 2001 May; 71(5 Suppl):S349-52. PMID: 11388221.
    View in: PubMed
  66. Mandelbrot DA, Oosterwegel MA, Shimizu K, Yamada A, Freeman GJ, Mitchell RN, Sayegh MH, Sharpe AH. B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4. J Clin Invest. 2001 Apr; 107(7):881-7. PMID: 11285307; PMCID: PMC199576.
  67. Nashar TO, Betteridge ZE, Mitchell RN. Evidence for a role of ganglioside GM1 in antigen presentation: binding enhances presentation of Escherichia coli enterotoxin B subunit (EtxB) to CD4(+) T cells. Int Immunol. 2001 Apr; 13(4):541-51. PMID: 11282993.
    View in: PubMed
  68. Delfs MW, Furukawa Y, Mitchell RN, Lichtman AH. CD8+ T cell subsets TC1 and TC2 cause different histopathologic forms of murine cardiac allograft rejection. Transplantation. 2001 Mar 15; 71(5):606-10. PMID: 11292288.
    View in: PubMed
  69. Madihally SV, Toner M, Yarmush ML, Mitchell RN. Peripheral blood mononuclear cells exhibit hypercatabolic activity in response to thermal injury correlating with diminished MHC I expression. J Trauma. 2001 Mar; 50(3):500-9. PMID: 11265030.
    View in: PubMed
  70. Zhao XM, Hu Y, Miller GG, Mitchell RN, Libby P. Association of thrombospondin-1 and cardiac allograft vasculopathy in human cardiac allografts. Circulation. 2001 Jan 30; 103(4):525-31. PMID: 11157717.
    View in: PubMed
  71. Shimizu K, Schönbeck U, Mach F, Libby P, Mitchell RN. Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation but does not prevent graft arteriosclerosis. J Immunol. 2000 Sep 15; 165(6):3506-18. PMID: 10975872.
    View in: PubMed
  72. Furukawa Y, Mandelbrot DA, Libby P, Sharpe AH, Mitchell RN. Association of B7-1 co-stimulation with the development of graft arterial disease. Studies using mice lacking B7-1, B7-2, or B7-1/B7-2. Am J Pathol. 2000 Aug; 157(2):473-84. PMID: 10934151; PMCID: PMC1850132.
  73. Chen RH, Kadner A, Mitchell RN, Santerre DH, Adams DH. alpha-Gal and beta-Gal are preferentially expressed on porcine cardiac microvascular endothelium. Transplant Proc. 2000 Aug; 32(5):877-8. PMID: 10936255.
    View in: PubMed
  74. Kadner A, Chen RH, Mitchell RN, Adams DH. Lack of ABH-antigen expression on human cardiac valves. J Heart Valve Dis. 2000 Jul; 9(4):512-6. PMID: 10947043.
    View in: PubMed
  75. Chen RH, Kadner A, Mitchell RN, Adams DH. Fresh porcine cardiac valves are not rejected in primates. J Thorac Cardiovasc Surg. 2000 Jun; 119(6):1216-20. PMID: 10838541.
    View in: PubMed
  76. Chen RH, Kadner A, Mitchell RN, Adams DH. Mechanism of delayed rejection in transgenic pig-to-primate cardiac xenotransplantation. J Surg Res. 2000 May 15; 90(2):119-25. PMID: 10792951.
    View in: PubMed
  77. Cheng PC, Dykstra ML, Mitchell RN, Pierce SK. A role for lipid rafts in B cell antigen receptor signaling and antigen targeting. J Exp Med. 1999 Dec 06; 190(11):1549-60. PMID: 10587346; PMCID: PMC2195743.
  78. Furukawa Y, Becker G, Stinn JL, Shimizu K, Libby P, Mitchell RN. Interleukin-10 (IL-10) augments allograft arterial disease: paradoxical effects of IL-10 in vivo. Am J Pathol. 1999 Dec; 155(6):1929-39. PMID: 10595923; PMCID: PMC1866915.
  79. Mandelbrot DA, Furukawa Y, McAdam AJ, Alexander SI, Libby P, Mitchell RN, Sharpe AH. Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts. J Immunol. 1999 Oct 01; 163(7):3753-7. PMID: 10490971.
    View in: PubMed
  80. Grosjean SA, Arstall MA, Mitchell RN, Klappacher GW, Kelly RA, Pfeffer MA, Pfeffer JM. Inducible nitric oxide synthase and tumor necrosis factor in animal models of myocardial necrosis induced by coronary artery ligation or isoproterenol injection. J Card Fail. 1999 Sep; 5(3):236-45. PMID: 10496196.
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  81. Chen RH, Mitchell RN, Kadner A, Adams DH. Differential galactose alpha(1,3) galactose expression by porcine cardiac vascular endothelium. Xenotransplantation. 1999 Aug; 6(3):169-72. PMID: 10503782.
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  82. Delacretaz E, Stevenson WG, Winters GL, Mitchell RN, Stewart S, Lynch K, Friedman PL. Ablation of ventricular tachycardia with a saline-cooled radiofrequency catheter: anatomic and histologic characteristics of the lesions in humans. J Cardiovasc Electrophysiol. 1999 Jun; 10(6):860-5. PMID: 10376924.
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  83. Nagano H, Tilney NL, Stinn JL, Becker G, Hasegawa S, Libby P, Mitchell RN. Deficiencies of IL-4 or TNF-alpha receptor-1 do not diminish graft arteriosclerosis in cardiac allografts. Transplant Proc. 1999 Feb-Mar; 31(1-2):152. PMID: 10083053.
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  84. Drake JR, Lewis TA, Condon KB, Mitchell RN, Webster P. Involvement of MIIC-like late endosomes in B cell receptor-mediated antigen processing in murine B cells. J Immunol. 1999 Jan 15; 162(2):1150-5. PMID: 9916746.
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  85. Stinn JL, Taylor MK, Becker G, Nagano H, Hasegawa S, Furakawa Y, Shimizu K, Libby P, Mitchell RN. Interferon-gamma-secreting T-cell populations in rejecting murine cardiac allografts: assessment by flow cytometry. Am J Pathol. 1998 Nov; 153(5):1383-92. PMID: 9811329; PMCID: PMC1853393.
  86. Hasegawa S, Becker G, Nagano H, Libby P, Mitchell RN. Pattern of graft- and host-specific MHC class II expression in long-term murine cardiac allografts: origin of inflammatory and vascular wall cells. Am J Pathol. 1998 Jul; 153(1):69-79. PMID: 9665467; PMCID: PMC1852929.
  87. Riese RJ, Mitchell RN, Villadangos JA, Shi GP, Palmer JT, Karp ER, De Sanctis GT, Ploegh HL, Chapman HA. Cathepsin S activity regulates antigen presentation and immunity. J Clin Invest. 1998 Jun 01; 101(11):2351-63. PMID: 9616206; PMCID: PMC508824.
  88. Nagano H, Libby P, Taylor MK, Hasegawa S, Stinn JL, Becker G, Tilney NL, Mitchell RN. Coronary arteriosclerosis after T-cell-mediated injury in transplanted mouse hearts: role of interferon-gamma. Am J Pathol. 1998 May; 152(5):1187-97. PMID: 9588888; PMCID: PMC1858591.
  89. Mitchell RN, Jonas RA, Schoen FJ. Pathology of explanted cryopreserved allograft heart valves: comparison with aortic valves from orthotopic heart transplants. J Thorac Cardiovasc Surg. 1998 Jan; 115(1):118-27. PMID: 9451054.
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  90. Reul RM, Fang JC, Denton MD, Geehan C, Long C, Mitchell RN, Ganz P, Briscoe DM. CD40 and CD40 ligand (CD154) are coexpressed on microvessels in vivo in human cardiac allograft rejection. Transplantation. 1997 Dec 27; 64(12):1765-74. PMID: 9422418.
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  91. Meckel CR, Anderson TJ, Mudge GH, Mitchell RN, Yeung AC, Selwyn AP, Ganz P, Simon DI. Hemostatic/fibrinolytic predictors of allograft coronary artery disease after cardiac transplantation. Vasc Med. 1997 Nov; 2(4):306-12. PMID: 9575604.
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  92. Nagano H, Mitchell RN, Taylor MK, Hasegawa S, Tilney NL, Libby P. Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts. J Clin Invest. 1997 Aug 01; 100(3):550-7. PMID: 9239401; PMCID: PMC508221.
  93. Antman EM, Grudzien C, Mitchell RN, Sacks DB. Detection of unsuspected myocardial necrosis by rapid bedside assay for cardiac troponin T. Am Heart J. 1997 May; 133(5):596-8. PMID: 9141383.
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  94. Libby P, Mitchell RN. Cytokines score a knockout. Harnessing gene targeting to gain insight into the pathogenesis of myocarditis. Circulation. 1997 Feb 04; 95(3):551-2. PMID: 9024133.
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  95. Mitchell RN, Jonas RA, Schoen FJ. Structure-function correlations in cryopreserved allograft cardiac valves. Ann Thorac Surg. 1995 Aug; 60(2 Suppl):S108-12; discussion S113. PMID: 7646139.
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  96. Schoen FJ, Mitchell RN, Jonas RA. Pathological considerations in cryopreserved allograft heart valves. J Heart Valve Dis. 1995 Jul; 4 Suppl 1:S72-5; discussion S75-6. PMID: 8581216.
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  97. Barnes KA, Mitchell RN. Detection of functional class II-associated antigen: role of a low density endosomal compartment in antigen processing. J Exp Med. 1995 May 01; 181(5):1715-27. PMID: 7722450; PMCID: PMC2192002.
  98. Mitchell RN, Barnes KA, Grupp SA, Sanchez M, Misulovin Z, Nussenzweig MC, Abbas AK. Intracellular targeting of antigens internalized by membrane immunoglobulin in B lymphocytes. J Exp Med. 1995 May 01; 181(5):1705-14. PMID: 7722449; PMCID: PMC2192014.
  99. Grupp SA, Mitchell RN, Schreiber KL, McKean DJ, Abbas AK. Molecular mechanisms that control expression of the B lymphocyte antigen receptor complex. J Exp Med. 1995 Jan 01; 181(1):161-8. PMID: 7807000; PMCID: PMC2191827.
  100. Grupp SA, Campbell K, Mitchell RN, Cambier JC, Abbas AK. Signaling-defective mutants of the B lymphocyte antigen receptor fail to associate with Ig-alpha and Ig-beta/gamma. J Biol Chem. 1993 Dec 05; 268(34):25776-9. PMID: 8245014.
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  101. Mitchell RN, Shaw AC, Weaver YK, Leder P, Abbas AK. Cytoplasmic tail deletion converts membrane immunoglobulin to a phosphatidylinositol-linked form lacking signaling and efficient antigen internalization functions. J Biol Chem. 1991 May 15; 266(14):8856-60. PMID: 2026599.
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  102. Shaw AC, Mitchell RN, Weaver YK, Campos-Torres J, Abbas AK, Leder P. Mutations of immunoglobulin transmembrane and cytoplasmic domains: effects on intracellular signaling and antigen presentation. Cell. 1990 Oct 19; 63(2):381-92. PMID: 2119890.
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  103. Mitchell RN, Harrison EH, Bowers WE. The use of radioactive cysteine methyl ester for labeling glycosylated molecules oxidized by periodate or neuraminidase plus galactose oxidase. Arch Biochem Biophys. 1984 Mar; 229(2):544-54. PMID: 6322696.
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  104. Mitchell RN, Bowers WE. Cell surface glycoproteins of rat lymphocytes. II. Protease-sensitive glycoproteins associated with mitogeni stimulation by periodate or neuraminidase plus galactose oxidase. J Immunol. 1980 Jun; 124(6):2632-40. PMID: 6246168.
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  105. Mitchell RN, Bowers WE. Cell surface glycoproteins of rat lymphocytes. I. Correlation of mitogenic stimulation by periodate or neuraminidase and galactose oxidase with the presence of papain-sensitive glycoproteins. J Immunol. 1978 Dec; 121(6):2181-92. PMID: 214497.
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  106. Mitchell, RN. Robbins and Cotran Pathologic Basis of Disease; Robbins Basic Pathology; Pocket Companion to Robbins and Cotran Pathologic Basis of Disease; Pathobiology of Human Disease.
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