Harvard Catalyst Profiles

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Richard Neal Mitchell, M.D., Ph.D.

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Mentoring
Available: 07/01/19, Expires: 06/30/21

Opportunity for 2 post-sophomore or post-junior medical students to work for a full year with full clinical responsibilities in a busy and exciting academic department of Pathology. Students with or without long-term career interest in pathology are invited to apply. Students will receive a foundational education in medicine through the pathologic basis of disease, have hands-on experiences, and participate in translational research. Students receive the same training as Pathology residents. A 3-month period for clinical-translational research with BWH Pathology Faculty mentors will satisfy the HMS scholarly project requirement. Stipend is $27000 (including $3000 from SMO, which students need to apply for). Multiple entry points (January, April, and July) are available; interested students should apply 2 months prior to a proposed start date. For more information, contact Rick Mitchell, MD, PhD, rmitchell@partners.org

Available: 07/01/19, Expires: 06/30/21

The fundamental hypothesis is that a well-done autopsy more often than not "stops" a malpractice suit from going forward. In other words, autopsies end up being a cost-effective mechanism for protecting physicians overall, and in keeping the bottom line of the hospital more robust. The project will test whether autopsies are superior/inferior/equivalent to non-autopsied deaths in affecting the rate and success of lawsuits. This would be part of a larger study to look at the rates of "missed" diagnoses found unexpectedly at autopsy, and quantifying whether they would have impacted patient care and/or outcomes. The hypothesis is that the numbers have not changed dramatically since the study published in 1983:

The value of the autopsy in three medical eras. Goldman L, Sayson R, Robbins S, Cohn LH, Bettmann M, Weisberg M. N Engl J Med. 1983 Apr 28;308(17):1000-5

The student will participate in all aspects of the study including data collation and analysis.

Selective Corneal Cross-Linking with use of Two-Photon Photochemical Activation
Summer, 05/28/13 - 09/03/13
Functional Characterization of a Novel Genetic Locus for Plasma Cholesterol
Summer, 01/07/13 - 01/31/14
The Determinants and Mechanism of B-ALL Entry to the CNS
Summer, 06/01/11 - 08/26/11
Assessment of Breast Cancer Risk Models in U.S. Populations
Summer, 06/16/14 - 09/01/14
Immunogenicity of Valvular Endothelium
Summer, 05/19/00 - 08/01/00
Characterization of the CD8 T Cell Response to MHV-68 Infection
Summer, 06/02/08 - 08/29/08
ENFDO CHEMOKIES IN TXAA
Summer, 07/01/03 - 08/31/03
Autologous cell-based high precision, closed-loop, optically-controlled insulin delivery
Summer, 05/28/09 - 08/28/09
Pathways of MHCII-dependent Antigen Presentation in B Cells
Summer, 05/24/99 - 08/27/99
Primary Mouth Development
Summer, 06/01/09 - 08/31/09
Clinical elective in internal medicine at McCord Hospital, Durban, South Africa
International, 01/30/06 - 02/24/06
International Clinical Elective - PUMC, China, Spring 2011
International, 02/28/11 - 04/22/11
Detecting inflammation: E. coli sensors of reactive oxygen species
Full Time, 05/31/12 - 08/31/12
Single Chromosome Amplification
Summer, 03/01/06 - 06/01/08
CA4+: a novel cationic contrast agent for evaluating glycosaminoglycan content by CT imaging
Part Time, 01/02/11 - 05/30/13
Molecular and cellular analysis of structural plasticity in the adult cortex of Par-4 mice
Summer, 06/01/07 - 08/31/07
Basement Membrane Regulation in the Primary Mouth Region
Summer, 07/14/10 - 09/01/10
Influence of metabolic regulation on primary cell proliferation and differentiation
Summer, 06/01/12 - 09/01/12

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13CA228237 (MITCHELL, RICHARD N) Apr 1, 2018 - Mar 31, 2019
    NIH
    2018 Annual Meeting of the American Society for Investigative Pathology
    Role: Principal Investigator
  2. R13CA217139 (MITCHELL, RICHARD N) Apr 20, 2017 - Apr 19, 2018
    NIH
    2017 Annual Meeting of the American Society for Investigative Pathology
    Role: Principal Investigator
  3. R01GM067049 (MITCHELL, RICHARD N) Mar 1, 2003 - Feb 28, 2007
    NIH
    Origin of Intimal cells in allograft arteriopathy
    Role: Principal Investigator
  4. R01GM047726 (MITCHELL, RICHARD N) Apr 1, 1992 - Mar 31, 2001
    NIH
    MEMBRANE RECEPTOR TRAFFICKING AND ANTIGEN PROCESSING
    Role: Principal Investigator
  5. R01HL043364 (MITCHELL, RICHARD N) Apr 1, 1990 - Sep 30, 2004
    NIH
    PATHOGENESIS OF TRANSPLANT ASSOCIATED ARTERIOSCLEROSIS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Diao JA, Wang JK, Chui WF, Mountain V, Gullapally SC, Srinivasan R, Mitchell RN, Glass B, Hoffman S, Rao SK, Maheshwari C, Lahiri A, Prakash A, McLoughlin R, Kerner JK, Resnick MB, Montalto MC, Khosla A, Wapinski IN, Beck AH, Elliott HL, Taylor-Weiner A. Human-interpretable image features derived from densely mapped cancer pathology slides predict diverse molecular phenotypes. Nat Commun. 2021 03 12; 12(1):1613. PMID: 33712588.
    Citations: 1     Fields:    
  2. Chauhan C, Coleman WB, Mitchell RN. Virtual Is the New Reality: American Society for Investigative Pathology Scientific Meetings, Conferences, and Events in the Age of Coronavirus Disease 2019. Am J Pathol. 2021 02; 191(2):218-221. PMID: 33518196.
    Citations:    Fields:    Translation:Humans
  3. Alba GA, Samokhin AO, Wang RS, Zhang YY, Wertheim BM, Arons E, Greenfield EA, Lundberg Slingsby MH, Ceglowski JR, Haley KJ, Bowman FP, Yu YR, Haney JC, Eng G, Mitchell RN, Sheets A, Vargas SO, Seo S, Channick RN, Leary PJ, Rajagopal S, Loscalzo J, Battinelli EM, Maron BA. NEDD9 is a Novel and Modifiable Mediator of Platelet-Endothelial Adhesion in the Pulmonary Circulation. Am J Respir Crit Care Med. 2021 Feb 01. PMID: 33523764.
    Citations:    Fields:    
  4. Aghayev A, Bay CP, Tedeschi S, Monach PA, Campia U, Gerhard-Herman M, Steigner ML, Mitchell RN, Docken WP, DiCarli M. Clinically isolated aortitis: imaging features and clinical outcomes: comparison with giant cell arteritis and giant cell aortitis. Int J Cardiovasc Imaging. 2021 Apr; 37(4):1433-1443. PMID: 33128155.
    Citations:    Fields:    
  5. Godfrey AK, Naqvi S, Chmátal L, Chick JM, Mitchell RN, Gygi SP, Skaletsky H, Page DC. Quantitative analysis of Y-Chromosome gene expression across 36 human tissues. Genome Res. 2020 06; 30(6):860-873. PMID: 32461223.
    Citations: 2     Fields:    
  6. Gartland RM, Myers LC, Iorgulescu JB, Nguyen AT, Yu-Moe CW, Falcone B, Mitchell R, Kachalia A, Mort E. Body of Evidence: Do Autopsy Findings Impact Medical Malpractice Claim Outcomes? J Patient Saf. 2020 Mar 23. PMID: 32209947.
    Citations:    Fields:    
  7. Kollar B, Rizzo NM, Borges TJ, Haug V, Abdulrazzak O, Kauke M, Safi AF, Lian CG, Marty FM, Rutherford AE, Mitchell RN, Murphy GF, Tullius SG, Riella LV, Pomahac B. Accelerated chronic skin changes without allograft vasculopathy: A 10-year outcome report after face transplantation. Surgery. 2020 06; 167(6):991-998. PMID: 32113580.
    Citations: 1     Fields:    Translation:HumansCells
  8. Naqvi S, Godfrey AK, Hughes JF, Goodheart ML, Mitchell RN, Page DC. Conservation, acquisition, and functional impact of sex-biased gene expression in mammals. Science. 2019 07 19; 365(6450). PMID: 31320509.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  9. Buja LM, Ottaviani G, Mitchell RN. Pathobiology of cardiovascular diseases: an update. Cardiovasc Pathol. 2019 Sep - Oct; 42:44-53. PMID: 31255975.
    Citations: 4     Fields:    Translation:Humans
  10. Schoen FJ, Mitchell RN. 2019 Society for Cardiovascular Pathology Distinguished Achievement Award Recipient -- Gayle L. Winters, M.D. Cardiovasc Pathol. 2019 Sep - Oct; 42:4-5. PMID: 31153109.
    Citations:    Fields:    Translation:Humans
  11. Shanmugam V, Mitchell RN, Padera RF, Wiesel O. Enterovascular Fistula: An Under-Recognized Complication Related to Therapy for Esophageal Carcinoma. J Laparoendosc Adv Surg Tech A. 2019 May; 29(5):583-588. PMID: 30562139.
    Citations:    Fields:    Translation:Humans
  12. Mitchell RN. When More Is Less. Circulation. 2018 11 27; 138(22):2527-2529. PMID: 30571358.
    Citations:    Fields:    Translation:AnimalsCells
  13. Glass CH, Christakis A, Fishbein GA, Watkins JC, Strickland KC, Mitchell RN, Padera RF. Thrombus on the inflow cannula of the HeartWare HVAD: an update. Cardiovasc Pathol. 2019 Jan - Feb; 38:14-20. PMID: 30399526.
    Citations: 4     Fields:    Translation:Humans
  14. Singh A, Geller HI, Alexander KM, Padera RF, Mitchell RN, Dorbala S, Castillo JJ, Falk RH. True, true unrelated? Coexistence of Waldenström macroglobulinemia and cardiac transthyretin amyloidosis. Haematologica. 2018 08; 103(8):e374-e376. PMID: 29674499.
    Citations: 1     Fields:    Translation:Humans
  15. Seidman MA, Mitchell RN. Genes in the Basement, Postmortem Genetic Testing…and 3 (New) Realities. Circ Cardiovasc Genet. 2017 12; 10(6). PMID: 29237695.
    Citations:    Fields:    Translation:Humans
  16. Geller HI, Singh A, Mirto TM, Padera R, Mitchell R, Laubach JP, Falk RH. Prevalence of Monoclonal Gammopathy in Wild-Type Transthyretin Amyloidosis. Mayo Clin Proc. 2017 Dec; 92(12):1800-1805. PMID: 29202938.
    Citations: 10     Fields:    Translation:Humans
  17. Minhas PS, Enogieru IE, Mitchell RN, Mata DA. Passport to pathology: transforming the medical student pathology elective from a passive educational experience to an exciting, immersive clinical rotation. Hum Pathol. 2017 10; 68:34-39. PMID: 28893532.
    Citations:    Fields:    Translation:Humans
  18. Chu Y, Mitchell RN, Mata DA. Improving undergraduate pathology teaching: medical students' perspective-reply. Hum Pathol. 2017 10; 68:203-204. PMID: 28890339.
    Citations:    Fields:    Translation:Humans
  19. Glass CK, Mitchell RN. Winning the battle, but losing the war: mechanisms and morphology of cancer-therapy-associated cardiovascular toxicity. Cardiovasc Pathol. 2017 Sep - Oct; 30:55-63. PMID: 28759820.
    Citations: 2     Fields:    Translation:Humans
  20. DeFilippis EM, Cuddy S, Glass C, Priya S, Aghayev A, Mitchell RN, Marty FM, DiCarli MF, Blankstein R. Use of Multimodality Imaging in Diagnosing Invasive Fungal Diseases of the Heart. Circ Cardiovasc Imaging. 2017 06; 10(6). PMID: 28576787.
    Citations:    Fields:    Translation:Humans
  21. Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M. Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017 04 20; 169(3):510-522.e20. PMID: 28431249.
    Citations: 183     Fields:    Translation:HumansAnimalsCells
  22. Badr Eslam R, Croce K, Mangione FM, Musmann R, Leopold JA, Mitchell RN, Waxman AB. Persistence and proliferation of human mesenchymal stromal cells in the right ventricular myocardium after intracoronary injection in a large animal model of pulmonary hypertension. Cytotherapy. 2017 06; 19(6):668-679. PMID: 28392314.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  23. Thomas R, Glass C, Mitchell RN, Steigner ML, Aghayev A. Giant cell aortitis mimicking intramural hematoma. J Cardiovasc Comput Tomogr. 2017 Jul - Aug; 11(4):327-328. PMID: 28196684.
    Citations:    Fields:    Translation:Humans
  24. Mangione FM, Jatene T, Gonçalves A, Fishbein GA, Mitchell RN, Pelletier MP, Kaneko T, Shah PB, Nyman CB, Shook D, Blankstein R, Padera RF, Bhatt DL. Leaflet Thrombosis in Surgically Explanted or Post-Mortem TAVR Valves. JACC Cardiovasc Imaging. 2017 01; 10(1):82-85. PMID: 28057222.
    Citations: 8     Fields:    Translation:Humans
  25. Farhad H, Staziaki PV, Addison D, Coelho-Filho OR, Shah RV, Mitchell RN, Szilveszter B, Abbasi SA, Kwong RY, Scherrer-Crosbie M, Hoffmann U, Jerosch-Herold M, Neilan TG. Characterization of the Changes in Cardiac Structure and Function in Mice Treated With Anthracyclines Using Serial Cardiac Magnetic Resonance Imaging. Circ Cardiovasc Imaging. 2016 Dec; 9(12). PMID: 27923796.
    Citations: 20     Fields:    Translation:Animals
  26. Halushka MK, Mitchell RN, Padera RF. Heart failure therapies: new strategies for old treatments and new treatments for old strategies. Cardiovasc Pathol. 2016 Nov - Dec; 25(6):503-511. PMID: 27619734.
    Citations: 2     Fields:    Translation:Humans
  27. Mahadevan NR, Morgan EA, Mitchell RN. Case report and literature review: cardiac tamponade as a complication of pericardial extramedullary hematopoiesis. Cardiovasc Pathol. 2016 Sep-Oct; 25(5):371-4. PMID: 27288747.
    Citations:    Fields:    Translation:Humans
  28. Halushka MK, Angelini A, Bartoloni G, Basso C, Batoroeva L, Bruneval P, Buja LM, Butany J, d'Amati G, Fallon JT, Gallagher PJ, Gittenberger-de Groot AC, Gouveia RH, Kholova I, Kelly KL, Leone O, Litovsky SH, Maleszewski JJ, Miller DV, Mitchell RN, Preston SD, Pucci A, Radio SJ, Rodriguez ER, Sheppard MN, Stone JR, Suvarna SK, Tan CD, Thiene G, Veinot JP, van der Wal AC. Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association For European Cardiovascular Pathology: II. Noninflammatory degenerative diseases - nomenclature and diagnostic criteria. Cardiovasc Pathol. 2016 May-Jun; 25(3):247-257. PMID: 27031798.
    Citations: 40     Fields:    Translation:Humans
  29. Chu Y, Mitchell RN, Mata DA. Using exit competencies to integrate pathology into the undergraduate clinical clerkships. Hum Pathol. 2016 Jan; 47(1):1-3. PMID: 26482607.
    Citations: 1     Fields:    Translation:Humans
  30. Torre M, Hwang DH, Padera RF, Mitchell RN, VanderLaan PA. Osseous and chondromatous metaplasia in calcific aortic valve stenosis. Cardiovasc Pathol. 2016 Jan-Feb; 25(1):18-24. PMID: 26386747.
    Citations: 8     Fields:    Translation:Humans
  31. Stone JR, Bruneval P, Angelini A, Bartoloni G, Basso C, Batoroeva L, Buja LM, Butany J, d'Amati G, Fallon JT, Gittenberger-de Groot AC, Gouveia RH, Halushka MK, Kelly KL, Kholova I, Leone O, Litovsky SH, Maleszewski JJ, Miller DV, Mitchell RN, Preston SD, Pucci A, Radio SJ, Rodriguez ER, Sheppard MN, Suvarna SK, Tan CD, Thiene G, van der Wal AC, Veinot JP. Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology: I. Inflammatory diseases. Cardiovasc Pathol. 2015 Sep-Oct; 24(5):267-78. PMID: 26051917.
    Citations: 36     Fields:    Translation:Humans
  32. Coelho-Filho OR, Shah RV, Neilan TG, Mitchell R, Moreno H, Kwong R, Jerosch-Herold M. Cardiac magnetic resonance assessment of interstitial myocardial fibrosis and cardiomyocyte hypertrophy in hypertensive mice treated with spironolactone. J Am Heart Assoc. 2014 Jun 25; 3(3):e000790. PMID: 24965024.
    Citations: 17     Fields:    Translation:AnimalsCells
  33. Zhang C, Jang S, Amadi OC, Shimizu K, Lee RT, Mitchell RN. A sensitive chemotaxis assay using a novel microfluidic device. Biomed Res Int. 2013; 2013:373569. PMID: 24151597.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  34. Coelho-Filho OR, Shah RV, Mitchell R, Neilan TG, Moreno H, Simonson B, Kwong R, Rosenzweig A, Das S, Jerosch-Herold M. Quantification of cardiomyocyte hypertrophy by cardiac magnetic resonance: implications for early cardiac remodeling. Circulation. 2013 Sep 10; 128(11):1225-33. PMID: 23912910.
    Citations: 37     Fields:    Translation:AnimalsCells
  35. Nelson KH, Chatzizisis YS, Steigner ML, Mitchell RN, Blankstein R, Givertz MM. Cardiac allograft involvement by post-transplantation lymphoproliferative disorder. J Am Coll Cardiol. 2013 Sep 03; 62(10):937. PMID: 23850919.
    Citations:    Fields:    Translation:Humans
  36. Mitchell RN. Learning from rejection: what transplantation teaches us about (other) vascular pathologies. J Autoimmun. 2013 Sep; 45:80-9. PMID: 23830871.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  37. Welt FG, Gallegos R, Connell J, Kajstura J, D'Amario D, Kwong RY, Coelho-Filho O, Shah R, Mitchell R, Leri A, Foley L, Anversa P, Pfeffer MA. Effect of cardiac stem cells on left-ventricular remodeling in a canine model of chronic myocardial infarction. Circ Heart Fail. 2013 Jan; 6(1):99-106. PMID: 23212553.
    Citations: 17     Fields:    Translation:Animals
  38. Coelho-Filho OR, Mongeon FP, Mitchell R, Moreno H, Nadruz W, Kwong R, Jerosch-Herold M. Role of transcytolemmal water-exchange in magnetic resonance measurements of diffuse myocardial fibrosis in hypertensive heart disease. Circ Cardiovasc Imaging. 2013 Jan 01; 6(1):134-41. PMID: 23159497.
    Citations: 34     Fields:    Translation:HumansAnimals
  39. Seidman MA, Mitchell RN. Surgical Pathology of Small- and Medium-Sized Vessels. Surg Pathol Clin. 2012 Jun; 5(2):435-51. PMID: 26838112.
    Citations: 2     Fields:    
  40. Furie MB, Mitchell RN. Plaque attack: one hundred years of atherosclerosis in The American Journal of Pathology. Am J Pathol. 2012 Jun; 180(6):2184-7. PMID: 22551843.
    Citations: 4     Fields:    Translation:HumansAnimals
  41. Herman DS, Lam L, Taylor MR, Wang L, Teekakirikul P, Christodoulou D, Conner L, DePalma SR, McDonough B, Sparks E, Teodorescu DL, Cirino AL, Banner NR, Pennell DJ, Graw S, Merlo M, Di Lenarda A, Sinagra G, Bos JM, Ackerman MJ, Mitchell RN, Murry CE, Lakdawala NK, Ho CY, Barton PJ, Cook SA, Mestroni L, Seidman JG, Seidman CE. Truncations of titin causing dilated cardiomyopathy. N Engl J Med. 2012 Feb 16; 366(7):619-28. PMID: 22335739.
    Citations: 377     Fields:    Translation:Humans
  42. Shimizu K, Libby P, Rocha VZ, Folco EJ, Shubiki R, Grabie N, Jang S, Lichtman AH, Shimizu A, Hogg N, Simon DI, Mitchell RN, Croce K. Loss of myeloid related protein-8/14 exacerbates cardiac allograft rejection. Circulation. 2011 Dec 20; 124(25):2920-32. PMID: 22144572.
    Citations: 13     Fields:    Translation:AnimalsCells
  43. D'Amario D, Fiorini C, Campbell PM, Goichberg P, Sanada F, Zheng H, Hosoda T, Rota M, Connell JM, Gallegos RP, Welt FG, Givertz MM, Mitchell RN, Leri A, Kajstura J, Pfeffer MA, Anversa P. Functionally competent cardiac stem cells can be isolated from endomyocardial biopsies of patients with advanced cardiomyopathies. Circ Res. 2011 Apr 01; 108(7):857-61. PMID: 21330601.
    Citations: 52     Fields:    Translation:HumansCells
  44. Coelho-Filho OR, Mongeon FP, Mitchell RN, Blankstein R, Jerosch-Herold M, Kwong RY. Images in cardiovascular medicine. Löffler endocarditis presenting with recurrent polymorphic ventricular tachycardia diagnosed by cardiac magnetic resonance imaging. Circulation. 2010 Jul 06; 122(1):96-9. PMID: 20606132.
    Citations: 2     Fields:    Translation:Humans
  45. Steven D, Roberts-Thomson KC, Seiler J, Inada K, Tedrow UB, Mitchell RN, Sobieszczyk PS, Eisenhauer AC, Couper GS, Stevenson WG. Ventricular tachycardia arising from the aortomitral continuity in structural heart disease: characteristics and therapeutic considerations for an anatomically challenging area of origin. Circ Arrhythm Electrophysiol. 2009 Dec; 2(6):660-6. PMID: 20009078.
    Citations: 8     Fields:    Translation:Humans
  46. Shimizu K, Minami M, Shubiki R, Lopez-Ilasaca M, MacFarlane L, Asami Y, Li Y, Mitchell RN, Libby P. CC chemokine receptor-1 activates intimal smooth muscle-like cells in graft arterial disease. Circulation. 2009 Nov 03; 120(18):1800-13. PMID: 19841301.
    Citations: 4     Fields:    Translation:AnimalsCells
  47. Okamoto Y, Christen T, Shimizu K, Asano K, Kihara S, Mitchell RN, Libby P. Adiponectin inhibits allograft rejection in murine cardiac transplantation. Transplantation. 2009 Oct 15; 88(7):879-83. PMID: 19935458.
    Citations: 13     Fields:    Translation:AnimalsCells
  48. Mitchell RN. Graft vascular disease: immune response meets the vessel wall. Annu Rev Pathol. 2009; 4:19-47. PMID: 18717641.
    Citations: 46     Fields:    Translation:HumansAnimals
  49. Shimizu K, Mitchell RN. The role of chemokines in transplant graft arterial disease. Arterioscler Thromb Vasc Biol. 2008 Nov; 28(11):1937-49. PMID: 18802020.
    Citations: 7     Fields:    Translation:HumansAnimals
  50. Shimizu K, Libby P, Shubiki R, Sakuma M, Wang Y, Asano K, Mitchell RN, Simon DI. Leukocyte integrin Mac-1 promotes acute cardiac allograft rejection. Circulation. 2008 Apr 15; 117(15):1997-2008. PMID: 18378617.
    Citations: 15     Fields:    Translation:AnimalsCells
  51. Duan X, Yarmush D, Leeder A, Yarmush ML, Mitchell RN. Burn-induced immunosuppression: attenuated T cell signaling independent of IFN-gamma- and nitric oxide-mediated pathways. J Leukoc Biol. 2008 Feb; 83(2):305-13. PMID: 18024716.
    Citations: 9     Fields:    Translation:AnimalsCells
  52. Mitchell RN, Libby P. Vascular remodeling in transplant vasculopathy. Circ Res. 2007 Apr 13; 100(7):967-78. PMID: 17431198.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  53. Song L, DePalma SR, Kharlap M, Zenovich AG, Cirino A, Mitchell R, McDonough B, Maron BJ, Seidman CE, Seidman JG, Ho CY. Novel locus for an inherited cardiomyopathy maps to chromosome 7. Circulation. 2006 May 09; 113(18):2186-92. PMID: 16651466.
    Citations: 7     Fields:    Translation:HumansCells
  54. Shimizu K, Mitchell RN, Libby P. Inflammation and cellular immune responses in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol. 2006 May; 26(5):987-94. PMID: 16497993.
    Citations: 182     Fields:    Translation:HumansAnimalsCells
  55. Taqueti VR, Mitchell RN, Lichtman AH. Protecting the pump: controlling myocardial inflammatory responses. Annu Rev Physiol. 2006; 68:67-95. PMID: 16460267.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  56. Sugiyama S, Kugiyama K, Nakamura S, Kataoka K, Aikawa M, Shimizu K, Koide S, Mitchell RN, Ogawa H, Libby P. Characterization of smooth muscle-like cells in circulating human peripheral blood. Atherosclerosis. 2006 Aug; 187(2):351-62. PMID: 16253262.
    Citations: 23     Fields:    Translation:HumansCells
  57. Monahan TS, Phaneuf MD, Contreras MA, Andersen ND, Popescu-Vladimir A, Bide MJ, Dempsey DJ, Mitchell RN, Hamdan AD, LoGerfo FW. In vivo testing of an infection-resistant annuloplasty ring. J Surg Res. 2006 Jan; 130(1):140-5. PMID: 16154148.
    Citations: 2     Fields:    Translation:Animals
  58. Shah RV, Mitchell RN. The role of stem cells in the response to myocardial and vascular wall injury. Cardiovasc Pathol. 2005 Sep-Oct; 14(5):225-31. PMID: 16168894.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  59. Lee CW, Mitchell RN, Horan RF, Castells MC. Cardiogenic shock and peripheral eosinophilia in a young woman. Ann Allergy Asthma Immunol. 2005 Sep; 95(3):229-33. PMID: 16200812.
    Citations: 2     Fields:    Translation:Humans
  60. Batirel HF, Batirel S, Mitchell RN, Swanson SJ. Interferon-gamma knockout fails to confer protection against obliteration in heterotopic murine tracheal allografts. J Heart Lung Transplant. 2005 Jun; 24(6):658-64. PMID: 15949724.
    Citations: 3     Fields:    Translation:Animals
  61. Shimizu K, Libby P, Mitchell RN. Local cytokine environments drive aneurysm formation in allografted aortas. Trends Cardiovasc Med. 2005 May; 15(4):142-8. PMID: 16099378.
    Citations: 8     Fields:    Translation:HumansAnimals
  62. Binello E, Mitchell RN, Harling OK. T cell uptake for the use of boron neutron capture as an immunologic research tool. Appl Radiat Isot. 2004 Nov; 61(5):959-62. PMID: 15308175.
    Citations:    Fields:    Translation:AnimalsCells
  63. Mitchell RN, Lichtman AH. The link between IFN-gamma and allograft arteriopathy: is the answer NO? J Clin Invest. 2004 Sep; 114(6):762-4. PMID: 15372099.
    Citations: 3     Fields:    Translation:Humans
  64. Furukawa Y, Cole SE, Shah RV, Fukumoto Y, Libby P, Mitchell RN. Wild-type but not interferon-gamma-deficient T cells induce graft arterial disease in the absence of B cells. Cardiovasc Res. 2004 Aug 01; 63(2):347-56. PMID: 15249193.
    Citations: 3     Fields:    Translation:AnimalsCells
  65. Shimizu K, Shichiri M, Libby P, Lee RT, Mitchell RN. Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas. J Clin Invest. 2004 Jul; 114(2):300-8. PMID: 15254597.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  66. Feinberg MW, Shimizu K, Lebedeva M, Haspel R, Takayama K, Chen Z, Frederick JP, Wang XF, Simon DI, Libby P, Mitchell RN, Jain MK. Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation. Circ Res. 2004 Mar 19; 94(5):601-8. PMID: 14752027.
    Citations: 35     Fields:    Translation:AnimalsCells
  67. Mitchell RN. Allograft arteriopathy: pathogenesis update. Cardiovasc Pathol. 2004 Jan-Feb; 13(1):33-40. PMID: 14761783.
    Citations: 9     Fields:    
  68. Shimizu K, Aikawa M, Takayama K, Libby P, Mitchell RN. Direct anti-inflammatory mechanisms contribute to attenuation of experimental allograft arteriosclerosis by statins. Circulation. 2003 Oct 28; 108(17):2113-20. PMID: 14517172.
    Citations: 25     Fields:    Translation:AnimalsCells
  69. Suzuki J, Cole SE, Batirel S, Kosuge H, Shimizu K, Isobe M, Libby P, Mitchell RN. Tumor necrosis factor receptor -1 and -2 double deficiency reduces graft arterial disease in murine cardiac allografts. Am J Transplant. 2003 Aug; 3(8):968-76. PMID: 12859531.
    Citations: 8     Fields:    Translation:Animals
  70. Shimizu K, Mitchell RN. Stem cell origins of intimal cells in graft arterial disease. Curr Atheroscler Rep. 2003 May; 5(3):230-7. PMID: 12667437.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  71. Sayegh MH, Wu Z, Hancock WW, Langmuir PB, Mata M, Sandner S, Kishimoto K, Sho M, Palmer E, Mitchell RN, Turka LA. Allograft rejection in a new allospecific CD4+ TCR transgenic mouse. Am J Transplant. 2003 Apr; 3(4):381-9. PMID: 12694059.
    Citations: 19     Fields:    Translation:AnimalsCells
  72. Madibally SV, Solomon V, Mitchell RN, Van De Water L, Yarmush ML, Toner M. Influence of insulin therapy on burn wound healing in rats. J Surg Res. 2003 Feb; 109(2):92-100. PMID: 12643849.
    Citations: 17     Fields:    Translation:Animals
  73. Madihally SV, Toner M, Yarmush ML, Mitchell RN. Interferon gamma modulates trauma-induced muscle wasting and immune dysfunction. Ann Surg. 2002 Nov; 236(5):649-57. PMID: 12409672.
    Citations: 5     Fields:    Translation:AnimalsCells
  74. Zhao DX, Hu Y, Miller GG, Luster AD, Mitchell RN, Libby P. Differential expression of the IFN-gamma-inducible CXCR3-binding chemokines, IFN-inducible protein 10, monokine induced by IFN, and IFN-inducible T cell alpha chemoattractant in human cardiac allografts: association with cardiac allograft vasculopathy and acute rejection. J Immunol. 2002 Aug 01; 169(3):1556-60. PMID: 12133984.
    Citations: 44     Fields:    Translation:Humans
  75. Solomon V, Madihally S, Mitchell RN, Yarmush M, Toner M. Antiproteolytic action of insulin in burn-injured rats. J Surg Res. 2002 Jun 15; 105(2):234-42. PMID: 12121712.
    Citations: 5     Fields:    Translation:Animals
  76. Nashar TO, Betteridge ZE, Mitchell RN. Antigen binding to GM1 ganglioside results in delayed presentation: minimal effects of GM1 on presentation of antigens internalized via other pathways. Immunology. 2002 May; 106(1):60-70. PMID: 11972633.
    Citations: 4     Fields:    Translation:AnimalsCells
  77. Halamay KE, Kirkman RL, Sun L, Yamada A, Fragoso RC, Shimizu K, Mitchell RN, McKay DB. CD8 T cells are sufficient to mediate allorecognition and allograft rejection. Cell Immunol. 2002 Mar-Apr; 216(1-2):6-14. PMID: 12381345.
    Citations: 9     Fields:    Translation:AnimalsCells
  78. Furukawa Y, Libby P, Stinn JL, Becker G, Mitchell RN. Cold ischemia induces isograft arteriopathy, but does not augment allograft arteriopathy in non-immunosuppressed hosts. Am J Pathol. 2002 Mar; 160(3):1077-87. PMID: 11891204.
    Citations: 6     Fields:    Translation:Animals
  79. Mitchell RN. Don't blame the lymphocyte: immunologic processes are NOT important in tissue valve failure. J Heart Valve Dis. 2001 Jul; 10(4):467-70. PMID: 11499592.
    Citations:    Fields:    Translation:HumansCells
  80. Shimizu K, Sugiyama S, Aikawa M, Aikawa M, Fukumoto Y, Rabkin E, Libby P, Mitchell RN. Host bone-marrow cells are a source of donor intimal smooth- muscle-like cells in murine aortic transplant arteriopathy. Nat Med. 2001 Jun; 7(6):738-41. PMID: 11385513.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  81. Kadner A, Chen RH, Mitchell RN, Adams DH. Hemograft crossmatching is unnecessary due to the absence of blood group antigens. Ann Thorac Surg. 2001 May; 71(5 Suppl):S349-52. PMID: 11388221.
    Citations: 2     Fields:    Translation:Humans
  82. Mandelbrot DA, Oosterwegel MA, Shimizu K, Yamada A, Freeman GJ, Mitchell RN, Sayegh MH, Sharpe AH. B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4. J Clin Invest. 2001 Apr; 107(7):881-7. PMID: 11285307.
    Citations: 22     Fields:    Translation:AnimalsCells
  83. Nashar TO, Betteridge ZE, Mitchell RN. Evidence for a role of ganglioside GM1 in antigen presentation: binding enhances presentation of Escherichia coli enterotoxin B subunit (EtxB) to CD4(+) T cells. Int Immunol. 2001 Apr; 13(4):541-51. PMID: 11282993.
    Citations: 16     Fields:    Translation:AnimalsCells
  84. Delfs MW, Furukawa Y, Mitchell RN, Lichtman AH. CD8+ T cell subsets TC1 and TC2 cause different histopathologic forms of murine cardiac allograft rejection. Transplantation. 2001 Mar 15; 71(5):606-10. PMID: 11292288.
    Citations: 6     Fields:    Translation:AnimalsCells
  85. Madihally SV, Toner M, Yarmush ML, Mitchell RN. Peripheral blood mononuclear cells exhibit hypercatabolic activity in response to thermal injury correlating with diminished MHC I expression. J Trauma. 2001 Mar; 50(3):500-9. PMID: 11265030.
    Citations: 2     Fields:    Translation:AnimalsCells
  86. Zhao XM, Hu Y, Miller GG, Mitchell RN, Libby P. Association of thrombospondin-1 and cardiac allograft vasculopathy in human cardiac allografts. Circulation. 2001 Jan 30; 103(4):525-31. PMID: 11157717.
    Citations: 12     Fields:    Translation:Humans
  87. Shimizu K, Schönbeck U, Mach F, Libby P, Mitchell RN. Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation but does not prevent graft arteriosclerosis. J Immunol. 2000 Sep 15; 165(6):3506-18. PMID: 10975872.
    Citations: 28     Fields:    Translation:AnimalsCells
  88. Furukawa Y, Mandelbrot DA, Libby P, Sharpe AH, Mitchell RN. Association of B7-1 co-stimulation with the development of graft arterial disease. Studies using mice lacking B7-1, B7-2, or B7-1/B7-2. Am J Pathol. 2000 Aug; 157(2):473-84. PMID: 10934151.
    Citations: 14     Fields:    Translation:AnimalsCells
  89. Chen RH, Kadner A, Mitchell RN, Santerre DH, Adams DH. alpha-Gal and beta-Gal are preferentially expressed on porcine cardiac microvascular endothelium. Transplant Proc. 2000 Aug; 32(5):877-8. PMID: 10936255.
    Citations:    Fields:    Translation:Animals
  90. Kadner A, Chen RH, Mitchell RN, Adams DH. Lack of ABH-antigen expression on human cardiac valves. J Heart Valve Dis. 2000 Jul; 9(4):512-6. PMID: 10947043.
    Citations:    Fields:    Translation:Humans
  91. Chen RH, Kadner A, Mitchell RN, Adams DH. Fresh porcine cardiac valves are not rejected in primates. J Thorac Cardiovasc Surg. 2000 Jun; 119(6):1216-20. PMID: 10838541.
    Citations: 1     Fields:    Translation:Animals
  92. Chen RH, Kadner A, Mitchell RN, Adams DH. Mechanism of delayed rejection in transgenic pig-to-primate cardiac xenotransplantation. J Surg Res. 2000 May 15; 90(2):119-25. PMID: 10792951.
    Citations: 1     Fields:    Translation:HumansAnimals
  93. Cheng PC, Dykstra ML, Mitchell RN, Pierce SK. A role for lipid rafts in B cell antigen receptor signaling and antigen targeting. J Exp Med. 1999 Dec 06; 190(11):1549-60. PMID: 10587346.
    Citations: 102     Fields:    Translation:AnimalsCells
  94. Furukawa Y, Becker G, Stinn JL, Shimizu K, Libby P, Mitchell RN. Interleukin-10 (IL-10) augments allograft arterial disease: paradoxical effects of IL-10 in vivo. Am J Pathol. 1999 Dec; 155(6):1929-39. PMID: 10595923.
    Citations: 15     Fields:    Translation:Animals
  95. Mandelbrot DA, Furukawa Y, McAdam AJ, Alexander SI, Libby P, Mitchell RN, Sharpe AH. Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts. J Immunol. 1999 Oct 01; 163(7):3753-7. PMID: 10490971.
    Citations: 16     Fields:    Translation:AnimalsCells
  96. Grosjean SA, Arstall MA, Mitchell RN, Klappacher GW, Kelly RA, Pfeffer MA, Pfeffer JM. Inducible nitric oxide synthase and tumor necrosis factor in animal models of myocardial necrosis induced by coronary artery ligation or isoproterenol injection. J Card Fail. 1999 Sep; 5(3):236-45. PMID: 10496196.
    Citations: 2     Fields:    Translation:Animals
  97. Chen RH, Mitchell RN, Kadner A, Adams DH. Differential galactose alpha(1,3) galactose expression by porcine cardiac vascular endothelium. Xenotransplantation. 1999 Aug; 6(3):169-72. PMID: 10503782.
    Citations: 2     Fields:    Translation:Animals
  98. Delacretaz E, Stevenson WG, Winters GL, Mitchell RN, Stewart S, Lynch K, Friedman PL. Ablation of ventricular tachycardia with a saline-cooled radiofrequency catheter: anatomic and histologic characteristics of the lesions in humans. J Cardiovasc Electrophysiol. 1999 Jun; 10(6):860-5. PMID: 10376924.
    Citations: 10     Fields:    Translation:Humans
  99. Nagano H, Tilney NL, Stinn JL, Becker G, Hasegawa S, Libby P, Mitchell RN. Deficiencies of IL-4 or TNF-alpha receptor-1 do not diminish graft arteriosclerosis in cardiac allografts. Transplant Proc. 1999 Feb-Mar; 31(1-2):152. PMID: 10083053.
    Citations:    Fields:    Translation:Animals
  100. Drake JR, Lewis TA, Condon KB, Mitchell RN, Webster P. Involvement of MIIC-like late endosomes in B cell receptor-mediated antigen processing in murine B cells. J Immunol. 1999 Jan 15; 162(2):1150-5. PMID: 9916746.
    Citations: 12     Fields:    Translation:AnimalsCells
  101. Stinn JL, Taylor MK, Becker G, Nagano H, Hasegawa S, Furakawa Y, Shimizu K, Libby P, Mitchell RN. Interferon-gamma-secreting T-cell populations in rejecting murine cardiac allografts: assessment by flow cytometry. Am J Pathol. 1998 Nov; 153(5):1383-92. PMID: 9811329.
    Citations: 11     Fields:    Translation:AnimalsCells
  102. Hasegawa S, Becker G, Nagano H, Libby P, Mitchell RN. Pattern of graft- and host-specific MHC class II expression in long-term murine cardiac allografts: origin of inflammatory and vascular wall cells. Am J Pathol. 1998 Jul; 153(1):69-79. PMID: 9665467.
    Citations: 13     Fields:    Translation:AnimalsCells
  103. Riese RJ, Mitchell RN, Villadangos JA, Shi GP, Palmer JT, Karp ER, De Sanctis GT, Ploegh HL, Chapman HA. Cathepsin S activity regulates antigen presentation and immunity. J Clin Invest. 1998 Jun 01; 101(11):2351-63. PMID: 9616206.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  104. Nagano H, Libby P, Taylor MK, Hasegawa S, Stinn JL, Becker G, Tilney NL, Mitchell RN. Coronary arteriosclerosis after T-cell-mediated injury in transplanted mouse hearts: role of interferon-gamma. Am J Pathol. 1998 May; 152(5):1187-97. PMID: 9588888.
    Citations: 18     Fields:    Translation:AnimalsCells
  105. Mitchell RN, Jonas RA, Schoen FJ. Pathology of explanted cryopreserved allograft heart valves: comparison with aortic valves from orthotopic heart transplants. J Thorac Cardiovasc Surg. 1998 Jan; 115(1):118-27. PMID: 9451054.
    Citations: 9     Fields:    Translation:Humans
  106. Reul RM, Fang JC, Denton MD, Geehan C, Long C, Mitchell RN, Ganz P, Briscoe DM. CD40 and CD40 ligand (CD154) are coexpressed on microvessels in vivo in human cardiac allograft rejection. Transplantation. 1997 Dec 27; 64(12):1765-74. PMID: 9422418.
    Citations: 10     Fields:    Translation:HumansCells
  107. Meckel CR, Anderson TJ, Mudge GH, Mitchell RN, Yeung AC, Selwyn AP, Ganz P, Simon DI. Hemostatic/fibrinolytic predictors of allograft coronary artery disease after cardiac transplantation. Vasc Med. 1997 Nov; 2(4):306-12. PMID: 9575604.
    Citations:    Fields:    Translation:Humans
  108. Nagano H, Mitchell RN, Taylor MK, Hasegawa S, Tilney NL, Libby P. Interferon-gamma deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts. J Clin Invest. 1997 Aug 01; 100(3):550-7. PMID: 9239401.
    Citations: 62     Fields:    Translation:Animals
  109. Antman EM, Grudzien C, Mitchell RN, Sacks DB. Detection of unsuspected myocardial necrosis by rapid bedside assay for cardiac troponin T. Am Heart J. 1997 May; 133(5):596-8. PMID: 9141383.
    Citations: 7     Fields:    Translation:Humans
  110. Libby P, Mitchell RN. Cytokines score a knockout. Harnessing gene targeting to gain insight into the pathogenesis of myocarditis. Circulation. 1997 Feb 04; 95(3):551-2. PMID: 9024133.
    Citations:    Fields:    Translation:Animals
  111. Mitchell RN, Jonas RA, Schoen FJ. Structure-function correlations in cryopreserved allograft cardiac valves. Ann Thorac Surg. 1995 Aug; 60(2 Suppl):S108-12; discussion S113. PMID: 7646139.
    Citations: 2     Fields:    Translation:HumansCells
  112. Schoen FJ, Mitchell RN, Jonas RA. Pathological considerations in cryopreserved allograft heart valves. J Heart Valve Dis. 1995 Jul; 4 Suppl 1:S72-5; discussion S75-6. PMID: 8581216.
    Citations: 2     Fields:    Translation:HumansCells
  113. Barnes KA, Mitchell RN. Detection of functional class II-associated antigen: role of a low density endosomal compartment in antigen processing. J Exp Med. 1995 May 01; 181(5):1715-27. PMID: 7722450.
    Citations: 13     Fields:    Translation:AnimalsCells
  114. Mitchell RN, Barnes KA, Grupp SA, Sanchez M, Misulovin Z, Nussenzweig MC, Abbas AK. Intracellular targeting of antigens internalized by membrane immunoglobulin in B lymphocytes. J Exp Med. 1995 May 01; 181(5):1705-14. PMID: 7722449.
    Citations: 21     Fields:    Translation:AnimalsCells
  115. Grupp SA, Mitchell RN, Schreiber KL, McKean DJ, Abbas AK. Molecular mechanisms that control expression of the B lymphocyte antigen receptor complex. J Exp Med. 1995 Jan 01; 181(1):161-8. PMID: 7807000.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  116. Grupp SA, Campbell K, Mitchell RN, Cambier JC, Abbas AK. Signaling-defective mutants of the B lymphocyte antigen receptor fail to associate with Ig-alpha and Ig-beta/gamma. J Biol Chem. 1993 Dec 05; 268(34):25776-9. PMID: 8245014.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  117. Mitchell RN, Shaw AC, Weaver YK, Leder P, Abbas AK. Cytoplasmic tail deletion converts membrane immunoglobulin to a phosphatidylinositol-linked form lacking signaling and efficient antigen internalization functions. J Biol Chem. 1991 May 15; 266(14):8856-60. PMID: 2026599.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  118. Shaw AC, Mitchell RN, Weaver YK, Campos-Torres J, Abbas AK, Leder P. Mutations of immunoglobulin transmembrane and cytoplasmic domains: effects on intracellular signaling and antigen presentation. Cell. 1990 Oct 19; 63(2):381-92. PMID: 2119890.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  119. Mitchell RN, Harrison EH, Bowers WE. The use of radioactive cysteine methyl ester for labeling glycosylated molecules oxidized by periodate or neuraminidase plus galactose oxidase. Arch Biochem Biophys. 1984 Mar; 229(2):544-54. PMID: 6322696.
    Citations:    Fields:    Translation:AnimalsCells
  120. Mitchell RN, Bowers WE. Cell surface glycoproteins of rat lymphocytes. II. Protease-sensitive glycoproteins associated with mitogeni stimulation by periodate or neuraminidase plus galactose oxidase. J Immunol. 1980 Jun; 124(6):2632-40. PMID: 6246168.
    Citations: 3     Fields:    Translation:AnimalsCells
  121. Mitchell RN, Bowers WE. Cell surface glycoproteins of rat lymphocytes. I. Correlation of mitogenic stimulation by periodate or neuraminidase and galactose oxidase with the presence of papain-sensitive glycoproteins. J Immunol. 1978 Dec; 121(6):2181-92. PMID: 214497.
    Citations:    Fields:    Translation:AnimalsCells
  122. Mitchell, RN. Robbins and Cotran Pathologic Basis of Disease; Robbins Basic Pathology; Pocket Companion to Robbins and Cotran Pathologic Basis of Disease; Pathobiology of Human Disease. Bio Page' target='_blank'>View Publication.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.