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John Henry Hartwig, Ph.D.

Title
Institution
Department
Address

Mentoring

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL104145 (HARTWIG, JOHN H) Jun 15, 2011 - May 31, 2015
    NIH/NHLBI
    Filamin A - Syk Interactions Modulate Platelet ITAM-based Signaling
    Role: Principal Investigator
  2. P01HL059561 (GEHA, RAIF SALIM) Sep 30, 1997 - Aug 31, 2014
    NIH/NHLBI
    SIGNALING AND CYTOSKELETAL ORGANIZATION IN BLOOD CELLS
    Role: Co-Principal Investigator
  3. P01HL056949 (WAGNER, DENISA D) Sep 5, 1996 - Jul 31, 2012
    NIH/NHLBI
    Adhesion Molecules in Transfusion Biology
    Role: Co-Principal Investigator
  4. R01HL056252 (HARTWIG, JOHN H) Apr 1, 1996 - Jun 30, 2009
    NIH/NHLBI
    Regulation of Platelet Shape Changes
    Role: Principal Investigator
  5. R01HL047874 (HARTWIG, JOHN H) Jun 1, 1991 - May 31, 1995
    NIH/NHLBI
    REGULATION OF PLATELET SHAPE CHANGES
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Stritt S, Birkholz I, Beck S, Sorrentino S, Sapra KT, Viaud J, Heck J, Gaits-Iacovoni F, Schulze H, Du X, Hartwig JH, Braun A, Bender M, Medalia O, Nieswandt B. Profilin 1-mediated cytoskeletal rearrangements regulate integrin function in mouse platelets. Blood Adv. 2018 05 08; 2(9):1040-1045. PMID: 29739775.
    Citations:    
  2. Hsu CP, Moghadaszadeh B, Hartwig JH, Beggs AH. Sarcomeric and nonmuscle a-actinin isoforms exhibit differential dynamics at skeletal muscle Z-lines. Cytoskeleton (Hoboken). 2018 05; 75(5):213-228. PMID: 29518289.
    Citations:    Fields:    
  3. Janssen E, Tohme M, Hedayat M, Leick M, Kumari S, Ramesh N, Massaad MJ, Ullas S, Azcutia V, Goodnow CC, Randall KL, Qiao Q, Wu H, Al-Herz W, Cox D, Hartwig J, Irvine DJ, Luscinskas FW, Geha RS. A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. J Clin Invest. 2016 10 03; 126(10):3837-3851. PMID: 27599296.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  4. Lu Y, Hanada T, Fujiwara Y, Nwankwo JO, Wieschhaus AJ, Hartwig J, Huang S, Han J, Chishti AH. Gene disruption of dematin causes precipitous loss of erythrocyte membrane stability and severe hemolytic anemia. Blood. 2016 07 07; 128(1):93-103. PMID: 27073223.
    Citations: 6     Fields:    Translation:AnimalsCells
  5. Machlus KR, Wu SK, Stumpo DJ, Soussou TS, Paul DS, Campbell RA, Kalwa H, Michel T, Bergmeier W, Weyrich AS, Blackshear PJ, Hartwig JH, Italiano JE. Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation. Blood. 2016 Mar 17; 127(11):1468-80. PMID: 26744461.
    Citations: 3     Fields:    Translation:AnimalsCells
  6. Song M, He Q, Berk BA, Hartwig JH, Stossel TP, Nakamura F. An adventitious interaction of filamin A with RhoGDI2(Tyr153Glu). Biochem Biophys Res Commun. 2016 Jan 15; 469(3):659-64. PMID: 26707877.
    Citations: 1     Fields:    Translation:HumansCells
  7. Poulter NS, Pollitt AY, Davies A, Malinova D, Nash GB, Hannon MJ, Pikramenou Z, Rappoport JZ, Hartwig JH, Owen DM, Thrasher AJ, Watson SP, Thomas SG. Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex. Nat Commun. 2015 Jun 01; 6:7254. PMID: 26028144.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  8. Begonja AJ, Pluthero FG, Suphamungmee W, Giannini S, Christensen H, Leung R, Lo RW, Nakamura F, Lehman W, Plomann M, Hoffmeister KM, Kahr WH, Hartwig JH, Falet H. FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets. Blood. 2015 Jul 02; 126(1):80-8. PMID: 25838348.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  9. Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B. Corrigendum: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. Nat Commun. 2015 Mar 06; 6:6507. PMID: 25744693.
    Citations: 1     Fields:    
  10. Grozovsky R, Begonja AJ, Liu K, Visner G, Hartwig JH, Falet H, Hoffmeister KM. The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling. Nat Med. 2015 Jan; 21(1):47-54. PMID: 25485912.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  11. Bender M, Thon JN, Ehrlicher AJ, Wu S, Mazutis L, Deschmann E, Sola-Visner M, Italiano JE, Hartwig JH. Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein. Blood. 2015 Jan 29; 125(5):860-8. PMID: 25411426.
    Citations: 10     Fields:    Translation:AnimalsCells
  12. Massaad MJ, Oyoshi MK, Kane J, Koduru S, Alcaide P, Nakamura F, Ramesh N, Luscinskas FW, Hartwig J, Geha RS. Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing. Mol Cell Biol. 2014 Dec 01; 34(23):4343-54. PMID: 25246631.
    Citations: 6     Fields:    Translation:AnimalsCells
  13. Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Heinze K, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B. Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. Nat Commun. 2014 Sep 04; 5:4746. PMID: 25187265.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  14. Nakamura F, Song M, Hartwig JH, Stossel TP. Documentation and localization of force-mediated filamin A domain perturbations in moving cells. Nat Commun. 2014 Aug 14; 5:4656. PMID: 25120197.
    Citations: 3     Fields:    Translation:AnimalsCells
  15. Gu C, Chang J, Shchedrina VA, Pham VA, Hartwig JH, Suphamungmee W, Lehman W, Hyman BT, Bacskai BJ, Sever S. Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity. Traffic. 2014 Aug; 15(8):819-38. PMID: 24891099.
    Citations: 6     Fields:    Translation:AnimalsCells
  16. Kim H, Falet H, Hoffmeister KM, Hartwig JH. Wiskott-Aldrich syndrome protein (WASp) controls the delivery of platelet transforming growth factor-ß1. J Biol Chem. 2013 Nov 29; 288(48):34352-63. PMID: 24133214.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  17. Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS. Paneth cells as a site of origin for intestinal inflammation. Nature. 2013 Nov 14; 503(7475):272-6. PMID: 24089213.
    Citations: 160     Fields:    Translation:AnimalsCells
  18. Wang Y, Zhao L, Suzuki A, Lian L, Min SH, Wang Z, Litvinov RI, Stalker TJ, Yago T, Klopocki AG, Schmidtke DW, Yin H, Choi JK, McEver RP, Weisel JW, Hartwig JH, Abrams CS. Platelets lacking PIP5KI? have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion. Blood. 2013 Apr 04; 121(14):2743-52. PMID: 23372168.
    Citations: 11     Fields:    Translation:AnimalsCells
  19. Mouneimne G, Hansen SD, Selfors LM, Petrak L, Hickey MM, Gallegos LL, Simpson KJ, Lim J, Gertler FB, Hartwig JH, Mullins RD, Brugge JS. Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion. Cancer Cell. 2012 Nov 13; 22(5):615-30. PMID: 23153535.
    Citations: 49     Fields:    Translation:HumansCells
  20. Bishai EA, Sidhu GS, Li W, Dhillon J, Bohil AB, Cheney RE, Hartwig JH, Southwick FS. Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spread. Cell Microbiol. 2013 Mar; 15(3):353-367. PMID: 23083060.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  21. Suphamungmee W, Nakamura F, Hartwig JH, Lehman W. Electron microscopy and 3D reconstruction reveals filamin Ig domain binding to F-actin. J Mol Biol. 2012 Dec 14; 424(5):248-56. PMID: 23041423.
    Citations: 4     Fields:    Translation:HumansCells
  22. Begonja AJ, Gambaryan S, Schulze H, Patel-Hett S, Italiano JE, Hartwig JH, Walter U. Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis. Exp Hematol. 2013 Jan; 41(1):91-101.e4. PMID: 22981933.
    Citations: 2     Fields:    Translation:AnimalsCells
  23. Thon JN, Macleod H, Begonja AJ, Zhu J, Lee KC, Mogilner A, Hartwig JH, Italiano JE. Microtubule and cortical forces determine platelet size during vascular platelet production. Nat Commun. 2012 May 22; 3:852. PMID: 22617292.
    Citations: 31     Fields:    Translation:HumansCells
  24. Wandall HH, Rumjantseva V, Sørensen AL, Patel-Hett S, Josefsson EC, Bennett EP, Italiano JE, Clausen H, Hartwig JH, Hoffmeister KM. The origin and function of platelet glycosyltransferases. Blood. 2012 Jul 19; 120(3):626-35. PMID: 22613794.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  25. Thomas GM, Carbo C, Curtis BR, Martinod K, Mazo IB, Schatzberg D, Cifuni SM, Fuchs TA, von Andrian UH, Hartwig JH, Aster RH, Wagner DD. Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice. Blood. 2012 Jun 28; 119(26):6335-43. PMID: 22596262.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  26. Rullo J, Becker H, Hyduk SJ, Wong JC, Digby G, Arora PD, Cano AP, Hartwig J, McCulloch CA, Cybulsky MI. Actin polymerization stabilizes a4ß1 integrin anchors that mediate monocyte adhesion. J Cell Biol. 2012 Apr 02; 197(1):115-29. PMID: 22472442.
    Citations: 12     Fields:    Translation:HumansCells
  27. Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD. B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012 Mar 22; 119(12):2819-28. PMID: 22302739.
    Citations: 45     Fields:    Translation:AnimalsCells
  28. Muehlschlegel JD, Perry TE, Liu KY, Fox AA, Smith SA, Lichtner P, Collard CD, Shernan SK, Hartwig JH, Body SC, Hoffmeister KM. Polymorphism in the protease-activated receptor-4 gene region associates with platelet activation and perioperative myocardial injury. Am J Hematol. 2012 Feb; 87(2):161-6. PMID: 22228373.
    Citations: 6     Fields:    Translation:HumansCells
  29. Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM. Desialylation accelerates platelet clearance after refrigeration and initiates GPIba metalloproteinase-mediated cleavage in mice. Blood. 2012 Feb 02; 119(5):1263-73. PMID: 22101895.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  30. Ehrlicher AJ, Nakamura F, Hartwig JH, Weitz DA, Stossel TP. Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A. Nature. 2011 Sep 18; 478(7368):260-3. PMID: 21926999.
    Citations: 105     Fields:    Translation:HumansAnimalsCells
  31. Hammarfjord O, Falet H, Gurniak C, Hartwig JH, Wallin RP. Gelsolin-independent podosome formation in dendritic cells. PLoS One. 2011; 6(7):e21615. PMID: 21779330.
    Citations: 6     Fields:    Translation:AnimalsCells
  32. Gay O, Gilquin B, Nakamura F, Jenkins ZA, McCartney R, Krakow D, Deshiere A, Assard N, Hartwig JH, Robertson SP, Baudier J. RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11464-9. PMID: 21709252.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  33. Jurak Begonja A, Hoffmeister KM, Hartwig JH, Falet H. FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly. Blood. 2011 Aug 25; 118(8):2285-95. PMID: 21652675.
    Citations: 25     Fields:    Translation:AnimalsCells
  34. Patel-Hett S, Wang H, Begonja AJ, Thon JN, Alden EC, Wandersee NJ, An X, Mohandas N, Hartwig JH, Italiano JE. The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation. Blood. 2011 Aug 11; 118(6):1641-52. PMID: 21566095.
    Citations: 19     Fields:    Translation:AnimalsCells
  35. Nakamura F, Stossel TP, Hartwig JH. The filamins: organizers of cell structure and function. Cell Adh Migr. 2011 Mar-Apr; 5(2):160-9. PMID: 21169733.
    Citations: 128     Fields:    Translation:HumansAnimalsCells
  36. Ehrlicher A, Hartwig JH. Cell mechanics: Contracting to stiffness. Nat Mater. 2011 Jan; 10(1):12-3. PMID: 21157494.
    Citations: 6     Fields:    Translation:Cells
  37. Thon JN, Montalvo A, Patel-Hett S, Devine MT, Richardson JL, Ehrlicher A, Larson MK, Hoffmeister K, Hartwig JH, Italiano JE. Cytoskeletal mechanics of proplatelet maturation and platelet release. J Cell Biol. 2010 Nov 15; 191(4):861-74. PMID: 21079248.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  38. Gu C, Yaddanapudi S, Weins A, Osborn T, Reiser J, Pollak M, Hartwig J, Sever S. Direct dynamin-actin interactions regulate the actin cytoskeleton. EMBO J. 2010 Nov 03; 29(21):3593-606. PMID: 20935625.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  39. Fuchs TA, Brill A, Duerschmied D, Schatzberg D, Monestier M, Myers DD, Wrobleski SK, Wakefield TW, Hartwig JH, Wagner DD. Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci U S A. 2010 Sep 07; 107(36):15880-5. PMID: 20798043.
    Citations: 340     Fields:    Translation:HumansAnimals
  40. Falet H, Pollitt AY, Begonja AJ, Weber SE, Duerschmied D, Wagner DD, Watson SP, Hartwig JH. A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J Exp Med. 2010 Aug 30; 207(9):1967-79. PMID: 20713593.
    Citations: 32     Fields:    Translation:AnimalsCells
  41. Moyer JD, Nowak RB, Kim NE, Larkin SK, Peters LL, Hartwig J, Kuypers FA, Fowler VM. Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton. Blood. 2010 Oct 07; 116(14):2590-9. PMID: 20585041.
    Citations: 41     Fields:    Translation:AnimalsCells
  42. Bender M, Eckly A, Hartwig JH, Elvers M, Pleines I, Gupta S, Krohne G, Jeanclos E, Gohla A, Gurniak C, Gachet C, Witke W, Nieswandt B. ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing. Blood. 2010 Sep 09; 116(10):1767-75. PMID: 20530287.
    Citations: 17     Fields:    Translation:AnimalsCells
  43. Playford MP, Nurminen E, Pentikäinen OT, Milgram SL, Hartwig JH, Stossel TP, Nakamura F. Cystic fibrosis transmembrane conductance regulator interacts with multiple immunoglobulin domains of filamin A. J Biol Chem. 2010 May 28; 285(22):17156-65. PMID: 20351098.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  44. Hughes CE, Pollitt AY, Mori J, Eble JA, Tomlinson MG, Hartwig JH, O'Callaghan CA, Fütterer K, Watson SP. CLEC-2 activates Syk through dimerization. Blood. 2010 Apr 08; 115(14):2947-55. PMID: 20154219.
    Citations: 44     Fields:    Translation:HumansCells
  45. Zhou AX, Hartwig JH, Akyürek LM. Filamins in cell signaling, transcription and organ development. Trends Cell Biol. 2010 Feb; 20(2):113-23. PMID: 20061151.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  46. Rumjantseva V, Grewal PK, Wandall HH, Josefsson EC, Sørensen AL, Larson G, Marth JD, Hartwig JH, Hoffmeister KM. Dual roles for hepatic lectin receptors in the clearance of chilled platelets. Nat Med. 2009 Nov; 15(11):1273-80. PMID: 19783995.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  47. Falet H, Marchetti MP, Hoffmeister KM, Massaad MJ, Geha RS, Hartwig JH. Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP. Blood. 2009 Nov 19; 114(21):4729-37. PMID: 19692704.
    Citations: 8     Fields:    Translation:AnimalsCells
  48. Koenderink GH, Dogic Z, Nakamura F, Bendix PM, MacKintosh FC, Hartwig JH, Stossel TP, Weitz DA. An active biopolymer network controlled by molecular motors. Proc Natl Acad Sci U S A. 2009 Sep 08; 106(36):15192-7. PMID: 19667200.
    Citations: 72     Fields:    Translation:Cells
  49. Sørensen AL, Rumjantseva V, Nayeb-Hashemi S, Clausen H, Hartwig JH, Wandall HH, Hoffmeister KM. Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes. Blood. 2009 Aug 20; 114(8):1645-54. PMID: 19520807.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  50. Bernimoulin M, Waters EK, Foy M, Steele BM, Sullivan M, Falet H, Walsh MT, Barteneva N, Geng JG, Hartwig JH, Maguire PB, Wagner DD. Differential stimulation of monocytic cells results in distinct populations of microparticles. J Thromb Haemost. 2009 Jun; 7(6):1019-28. PMID: 19548909.
    Citations: 33     Fields:    Translation:HumansCells
  51. Adamovich DA, Nakamura F, Worth A, Burns S, Thrasher AJ, Hartwig JH, Snapper SB. Activating mutations of N-WASP alter Shigella pathogenesis. Biochem Biophys Res Commun. 2009 Jul 03; 384(3):284-9. PMID: 19379711.
    Citations: 5     Fields:    Translation:AnimalsCells
  52. Le Bras S, Massaad M, Koduru S, Kumar L, Oyoshi MK, Hartwig J, Geha RS. WIP is critical for T cell responsiveness to IL-2. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7519-24. PMID: 19359486.
    Citations: 11     Fields:    Translation:AnimalsCells
  53. Nakamura F, Heikkinen O, Pentikäinen OT, Osborn TM, Kasza KE, Weitz DA, Kupiainen O, Permi P, Kilpeläinen I, Ylänne J, Hartwig JH, Stossel TP. Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations. PLoS One. 2009; 4(3):e4928. PMID: 19293932.
    Citations: 32     Fields:    Translation:HumansCells
  54. Wang Y, Chen X, Lian L, Tang T, Stalker TJ, Sasaki T, Kanaho Y, Brass LF, Choi JK, Hartwig JH, Abrams CS. Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14064-9. PMID: 18772378.
    Citations: 24     Fields:    Translation:AnimalsCells
  55. Randhawa VK, Ishikura S, Talior-Volodarsky I, Cheng AW, Patel N, Hartwig JH, Klip A. GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells. J Biol Chem. 2008 Oct 03; 283(40):27208-19. PMID: 18650435.
    Citations: 33     Fields:    Translation:AnimalsCells
  56. Salomao M, Zhang X, Yang Y, Lee S, Hartwig JH, Chasis JA, Mohandas N, An X. Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane. Proc Natl Acad Sci U S A. 2008 Jun 10; 105(23):8026-31. PMID: 18524950.
    Citations: 81     Fields:    Translation:AnimalsCells
  57. Wang Y, Litvinov RI, Chen X, Bach TL, Lian L, Petrich BG, Monkley SJ, Kanaho Y, Critchley DR, Sasaki T, Birnbaum MJ, Weisel JW, Hartwig J, Abrams CS. Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J Clin Invest. 2008 Feb; 118(2):812-9. PMID: 18188447.
    Citations: 34     Fields:    Translation:AnimalsCells
  58. Patel-Hett S, Richardson JL, Schulze H, Drabek K, Isaac NA, Hoffmeister K, Shivdasani RA, Bulinski JC, Galjart N, Hartwig JH, Italiano JE. Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules. Blood. 2008 May 01; 111(9):4605-16. PMID: 18230754.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  59. Wandall HH, Hoffmeister KM, Sørensen AL, Rumjantseva V, Clausen H, Hartwig JH, Slichter SJ. Galactosylation does not prevent the rapid clearance of long-term, 4 degrees C-stored platelets. Blood. 2008 Mar 15; 111(6):3249-56. PMID: 18096766.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  60. Nakamura F, Osborn TM, Hartemink CA, Hartwig JH, Stossel TP. Structural basis of filamin A functions. J Cell Biol. 2007 Dec 03; 179(5):1011-25. PMID: 18056414.
    Citations: 103     Fields:    Translation:HumansCells
  61. Bai J, Hartwig JH, Perrimon N. SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth. Dev Cell. 2007 Dec; 13(6):828-42. PMID: 18061565.
    Citations: 33     Fields:    Translation:AnimalsCells
  62. Weins A, Schlondorff JS, Nakamura F, Denker BM, Hartwig JH, Stossel TP, Pollak MR. Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16080-5. PMID: 17901210.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  63. Battinelli EM, Hartwig JH, Italiano JE. Delivering new insight into the biology of megakaryopoiesis and thrombopoiesis. Curr Opin Hematol. 2007 Sep; 14(5):419-26. PMID: 17934346.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  64. Italiano JE, Patel-Hett S, Hartwig JH. Mechanics of proplatelet elaboration. J Thromb Haemost. 2007 Jul; 5 Suppl 1:18-23. PMID: 17635704.
    Citations: 30     Fields:    Translation:HumansCells
  65. Babic AM, Josefsson EC, Bergmeier W, Wagner DD, Kaufman RM, Silberstein LE, Stossel TP, Hartwig JH, Hoffmeister KM. In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration. Transfusion. 2007 Mar; 47(3):442-51. PMID: 17319824.
    Citations: 12     Fields:    Translation:HumansCells
  66. Osborn TM, Dahlgren C, Hartwig JH, Stossel TP. Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1323-30. PMID: 17135294.
    Citations: 29     Fields:    Translation:HumansCells
  67. Stossel TP, Fenteany G, Hartwig JH. Cell surface actin remodeling. J Cell Sci. 2006 Aug 15; 119(Pt 16):3261-4. PMID: 16899816.
    Citations: 21     Fields:    Translation:HumansCells
  68. Kalfa TA, Pushkaran S, Mohandas N, Hartwig JH, Fowler VM, Johnson JF, Joiner CH, Williams DA, Zheng Y. Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood. 2006 Dec 01; 108(12):3637-45. PMID: 16882712.
    Citations: 42     Fields:    Translation:AnimalsCells
  69. Ohta Y, Hartwig JH, Stossel TP. FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling. Nat Cell Biol. 2006 Aug; 8(8):803-14. PMID: 16862148.
    Citations: 145     Fields:    Translation:HumansAnimalsCells
  70. Gardel ML, Nakamura F, Hartwig J, Crocker JC, Stossel TP, Weitz DA. Stress-dependent elasticity of composite actin networks as a model for cell behavior. Phys Rev Lett. 2006 Mar 03; 96(8):088102. PMID: 16606229.
    Citations: 40     Fields:    Translation:AnimalsCells
  71. Hartwig JH, Italiano JE. Cytoskeletal mechanisms for platelet production. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):99-103. PMID: 16464622.
    Citations: 17     Fields:    Translation:AnimalsCells
  72. Gardel ML, Nakamura F, Hartwig JH, Crocker JC, Stossel TP, Weitz DA. Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1762-7. PMID: 16446458.
    Citations: 109     Fields:    Translation:HumansAnimalsCells
  73. Hartwig JH. The platelet: form and function. Semin Hematol. 2006 Jan; 43(1 Suppl 1):S94-100. PMID: 16427392.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  74. Patel SR, Hartwig JH, Italiano JE. The biogenesis of platelets from megakaryocyte proplatelets. J Clin Invest. 2005 Dec; 115(12):3348-54. PMID: 16322779.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  75. Nakamura F, Pudas R, Heikkinen O, Permi P, Kilpeläinen I, Munday AD, Hartwig JH, Stossel TP, Ylänne J. The structure of the GPIb-filamin A complex. Blood. 2006 Mar 01; 107(5):1925-32. PMID: 16293600.
    Citations: 59     Fields:    Translation:HumansCells
  76. Di Nardo A, Cicchetti G, Falet H, Hartwig JH, Stossel TP, Kwiatkowski DJ. Arp2/3 complex-deficient mouse fibroblasts are viable and have normal leading-edge actin structure and function. Proc Natl Acad Sci U S A. 2005 Nov 08; 102(45):16263-8. PMID: 16254049.
    Citations: 23     Fields:    Translation:AnimalsCells
  77. Hartwig J. Synthetic chemistry: recipes for excess. Nature. 2005 Sep 22; 437(7058):487-8. PMID: 16177775.
    Citations:    Fields:    Translation:Cells
  78. Osborn EA, Rabodzey A, Dewey CF, Hartwig JH. Endothelial actin cytoskeleton remodeling during mechanostimulation with fluid shear stress. Am J Physiol Cell Physiol. 2006 Feb; 290(2):C444-52. PMID: 16176968.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  79. Patel SR, Richardson JL, Schulze H, Kahle E, Galjart N, Drabek K, Shivdasani RA, Hartwig JH, Italiano JE. Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood. 2005 Dec 15; 106(13):4076-85. PMID: 16118321.
    Citations: 54     Fields:    Translation:AnimalsCells
  80. Richardson JL, Shivdasani RA, Boers C, Hartwig JH, Italiano JE. Mechanisms of organelle transport and capture along proplatelets during platelet production. Blood. 2005 Dec 15; 106(13):4066-75. PMID: 16118320.
    Citations: 36     Fields:    Translation:AnimalsCells
  81. Nakamura F, Hartwig JH, Stossel TP, Szymanski PT. Ca2+ and calmodulin regulate the binding of filamin A to actin filaments. J Biol Chem. 2005 Sep 16; 280(37):32426-33. PMID: 16030015.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  82. Falet H, Chang G, Brohard-Bohn B, Rendu F, Hartwig JH. Integrin alpha(IIb)beta3 signals lead cofilin to accelerate platelet actin dynamics. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C819-25. PMID: 15901596.
    Citations: 10     Fields:    Translation:HumansCells
  83. Josefsson EC, Gebhard HH, Stossel TP, Hartwig JH, Hoffmeister KM. The macrophage alphaMbeta2 integrin alphaM lectin domain mediates the phagocytosis of chilled platelets. J Biol Chem. 2005 May 06; 280(18):18025-32. PMID: 15741160.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  84. Wiederhold T, Lee MF, James M, Neujahr R, Smith N, Murthy A, Hartwig J, Gusella JF, Ramesh V. Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2. Oncogene. 2004 Nov 18; 23(54):8815-25. PMID: 15467741.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  85. Rodal AA, Kozubowski L, Goode BL, Drubin DG, Hartwig JH. Actin and septin ultrastructures at the budding yeast cell cortex. Mol Biol Cell. 2005 Jan; 16(1):372-84. PMID: 15525671.
    Citations: 77     Fields:    Translation:AnimalsCells
  86. Kettner A, Kumar L, Antón IM, Sasahara Y, de la Fuente M, Pivniouk VI, Falet H, Hartwig JH, Geha RS. WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells. J Exp Med. 2004 Feb 02; 199(3):357-68. PMID: 14757742.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  87. Sobocka MB, Sobocki T, Babinska A, Hartwig JH, Li M, Ehrlich YH, Kornecki E. Signaling pathways of the F11 receptor (F11R; a.k.a. JAM-1, JAM-A) in human platelets: F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa. J Recept Signal Transduct Res. 2004 Feb; 24(1-2):85-105. PMID: 15344881.
    Citations: 9     Fields:    Translation:HumansCells
  88. Pivniouk VI, Snapper SB, Kettner A, Alenius H, Laouini D, Falet H, Hartwig J, Alt FW, Geha RS. Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells. Int Immunol. 2003 Dec; 15(12):1431-40. PMID: 14645152.
    Citations: 18     Fields:    Translation:AnimalsCells
  89. Hoffmeister KM, Josefsson EC, Isaac NA, Clausen H, Hartwig JH, Stossel TP. Glycosylation restores survival of chilled blood platelets. Science. 2003 Sep 12; 301(5639):1531-4. PMID: 12970565.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  90. Bergmeier W, Burger PC, Piffath CL, Hoffmeister KM, Hartwig JH, Nieswandt B, Wagner DD. Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets. Blood. 2003 Dec 01; 102(12):4229-35. PMID: 12907434.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  91. Hartwig J, Italiano J. The birth of the platelet. J Thromb Haemost. 2003 Jul; 1(7):1580-6. PMID: 12871294.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  92. Barkalow KL, Falet H, Italiano JE, van Vugt A, Carpenter CL, Schreiber AD, Hartwig JH. Role for phosphoinositide 3-kinase in Fc gamma RIIA-induced platelet shape change. Am J Physiol Cell Physiol. 2003 Oct; 285(4):C797-805. PMID: 12788695.
    Citations: 2     Fields:    Translation:HumansCells
  93. Barkalow KL, Italiano JE, Chou DE, Matsuoka Y, Bennett V, Hartwig JH. Alpha-adducin dissociates from F-actin and spectrin during platelet activation. J Cell Biol. 2003 May 12; 161(3):557-70. PMID: 12743105.
    Citations: 27     Fields:    Translation:HumansCells
  94. Paul BZ, Kim S, Dangelmaier C, Nagaswami C, Jin J, Hartwig JH, Weisel JW, Daniel JL, Kunapuli SP. Dynamic regulation of microtubule coils in ADP-induced platelet shape change by p160ROCK (Rho-kinase). Platelets. 2003 May; 14(3):159-69. PMID: 12850840.
    Citations: 5     Fields:    Translation:HumansCells
  95. Antón IM, Saville SP, Byrne MJ, Curcio C, Ramesh N, Hartwig JH, Geha RS. WIP participates in actin reorganization and ruffle formation induced by PDGF. J Cell Sci. 2003 Jun 15; 116(Pt 12):2443-51. PMID: 12724353.
    Citations: 21     Fields:    Translation:AnimalsCells
  96. Stossel TP, Hartwig JH. Filling gaps in signaling to actin cytoskeletal remodeling. Dev Cell. 2003 Apr; 4(4):444-5. PMID: 12689583.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  97. Italiano JE, Bergmeier W, Tiwari S, Falet H, Hartwig JH, Hoffmeister KM, André P, Wagner DD, Shivdasani RA. Mechanisms and implications of platelet discoid shape. Blood. 2003 Jun 15; 101(12):4789-96. PMID: 12586623.
    Citations: 31     Fields:    Translation:AnimalsCells
  98. Hoffmeister KM, Felbinger TW, Falet H, Denis CV, Bergmeier W, Mayadas TN, von Andrian UH, Wagner DD, Stossel TP, Hartwig JH. The clearance mechanism of chilled blood platelets. Cell. 2003 Jan 10; 112(1):87-97. PMID: 12526796.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  99. Falet H, Hoffmeister KM, Neujahr R, Italiano JE, Stossel TP, Southwick FS, Hartwig JH. Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16782-7. PMID: 12464680.
    Citations: 25     Fields:    Translation:HumansCells
  100. Falet H, Hoffmeister KM, Neujahr R, Hartwig JH. Normal Arp2/3 complex activation in platelets lacking WASp. Blood. 2002 Sep 15; 100(6):2113-22. PMID: 12200375.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  101. Antón IM, de la Fuente MA, Sims TN, Freeman S, Ramesh N, Hartwig JH, Dustin ML, Geha RS. WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation. Immunity. 2002 Feb; 16(2):193-204. PMID: 11869681.
    Citations: 44     Fields:    Translation:AnimalsCells
  102. Flanagan LA, Chou J, Falet H, Neujahr R, Hartwig JH, Stossel TP. Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells. J Cell Biol. 2001 Nov 12; 155(4):511-7. PMID: 11706047.
    Citations: 68     Fields:    Translation:HumansCells
  103. Snapper SB, Takeshima F, Antón I, Liu CH, Thomas SM, Nguyen D, Dudley D, Fraser H, Purich D, Lopez-Ilasaca M, Klein C, Davidson L, Bronson R, Mulligan RC, Southwick F, Geha R, Goldberg MB, Rosen FS, Hartwig JH, Alt FW. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat Cell Biol. 2001 Oct; 3(10):897-904. PMID: 11584271.
    Citations: 110     Fields:    Translation:AnimalsCells
  104. Cunningham CC, Vegners R, Bucki R, Funaki M, Korde N, Hartwig JH, Stossel TP, Janmey PA. Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J Biol Chem. 2001 Nov 16; 276(46):43390-9. PMID: 11533030.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  105. James MF, Manchanda N, Gonzalez-Agosti C, Hartwig JH, Ramesh V. The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association. Biochem J. 2001 Jun 01; 356(Pt 2):377-86. PMID: 11368764.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  106. Hartwig J. Transfusion medicine illustrated. The human blood platelet, resting and active. Transfusion. 2001 Jun; 41(6):723. PMID: 11399808.
    Citations:    Fields:    Translation:HumansCells
  107. Martinez-Quiles N, Rohatgi R, Antón IM, Medina M, Saville SP, Miki H, Yamaguchi H, Takenawa T, Hartwig JH, Geha RS, Ramesh N. WIP regulates N-WASP-mediated actin polymerization and filopodium formation. Nat Cell Biol. 2001 May; 3(5):484-91. PMID: 11331876.
    Citations: 75     Fields:    Translation:AnimalsCells
  108. Hoffmeister KM, Falet H, Toker A, Barkalow KL, Stossel TP, Hartwig JH. Mechanisms of cold-induced platelet actin assembly. J Biol Chem. 2001 Jul 06; 276(27):24751-9. PMID: 11328807.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  109. Schwer HD, Lecine P, Tiwari S, Italiano JE, Hartwig JH, Shivdasani RA. A lineage-restricted and divergent beta-tubulin isoform is essential for the biogenesis, structure and function of blood platelets. Curr Biol. 2001 Apr 17; 11(8):579-86. PMID: 11369202.
    Citations: 52     Fields:    Translation:AnimalsCells
  110. Stossel TP, Condeelis J, Cooley L, Hartwig JH, Noegel A, Schleicher M, Shapiro SS. Filamins as integrators of cell mechanics and signalling. Nat Rev Mol Cell Biol. 2001 Feb; 2(2):138-45. PMID: 11252955.
    Citations: 277     Fields:    Translation:Cells
  111. Hartwig JH, Barkalov K, Italiano J. The Dynamic Cytoskeleton of the Megakaryocyte. Cell Mol Biol Lett. 2001; 6(2):208. PMID: 11544661.
    Citations:    Fields:    
  112. Falet H, Barkalow KL, Pivniouk VI, Barnes MJ, Geha RS, Hartwig JH. Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcR gamma-chain complex. Blood. 2000 Dec 01; 96(12):3786-92. PMID: 11090061.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  113. McGrath JL, Hartwig JH, Kuo SC. The mechanics of F-actin microenvironments depend on the chemistry of probing surfaces. Biophys J. 2000 Dec; 79(6):3258-66. PMID: 11106629.
    Citations: 11     Fields:    Translation:AnimalsCells
  114. Glogauer M, Hartwig J, Stossel T. Two pathways through Cdc42 couple the N-formyl receptor to actin nucleation in permeabilized human neutrophils. J Cell Biol. 2000 Aug 21; 150(4):785-96. PMID: 10953003.
    Citations: 28     Fields:    Translation:HumansCells
  115. McGrath JL, Osborn EA, Tardy YS, Dewey CF, Hartwig JH. Regulation of the actin cycle in vivo by actin filament severing. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6532-7. PMID: 10823888.
    Citations: 14     Fields:    Translation:AnimalsCells
  116. Frenette PS, Denis CV, Weiss L, Jurk K, Subbarao S, Kehrel B, Hartwig JH, Vestweber D, Wagner DD. P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo. J Exp Med. 2000 Apr 17; 191(8):1413-22. PMID: 10770806.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  117. Sobocka MB, Sobocki T, Banerjee P, Weiss C, Rushbrook JI, Norin AJ, Hartwig J, Salifu MO, Markell MS, Babinska A, Ehrlich YH, Kornecki E. Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation. Blood. 2000 Apr 15; 95(8):2600-9. PMID: 10753840.
    Citations: 17     Fields:    Translation:HumansCells
  118. Tolias KF, Hartwig JH, Ishihara H, Shibasaki Y, Cantley LC, Carpenter CL. Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly. Curr Biol. 2000 Feb 10; 10(3):153-6. PMID: 10679324.
    Citations: 68     Fields:    Translation:AnimalsCells
  119. Azim AC, Barkalow K, Chou J, Hartwig JH. Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor. Blood. 2000 Feb 01; 95(3):959-64. PMID: 10648409.
    Citations: 20     Fields:    Translation:HumansCells
  120. Azim AC, Barkalow KL, Hartwig JH. Determination of GTP loading on Rac and Cdc42 in platelets and fibroblasts. Methods Enzymol. 2000; 325:257-63. PMID: 11036608.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  121. Cheng Y, Hartemink CA, Hartwig JH, Dewey CF. Three-dimensional reconstruction of the actin cytoskeleton from stereo images. J Biomech. 2000 Jan; 33(1):105-13. PMID: 10609523.
    Citations: 3     Fields:    Translation:AnimalsCells
  122. Hartwig JH, Barkalow KL. Actin filament assembly in permeabilized platelets. Methods Enzymol. 2000; 325:349-56. PMID: 11036617.
    Citations:    Fields:    Translation:HumansCells
  123. Italiano JE, Lecine P, Shivdasani RA, Hartwig JH. Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol. 1999 Dec 13; 147(6):1299-312. PMID: 10601342.
    Citations: 121     Fields:    Translation:AnimalsCells
  124. Hartwig JH, Barkalow K, Azim A, Italiano J. The elegant platelet: signals controlling actin assembly. Thromb Haemost. 1999 Aug; 82(2):392-8. PMID: 10605729.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  125. Ohta Y, Suzuki N, Nakamura S, Hartwig JH, Stossel TP. The small GTPase RalA targets filamin to induce filopodia. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2122-8. PMID: 10051605.
    Citations: 123     Fields:    Translation:HumansAnimalsCells
  126. Carpenter CL, Tolias KF, Van Vugt A, Hartwig J. Lipid kinases are novel effectors of the GTPase Rac1. Adv Enzyme Regul. 1999; 39:299-312. PMID: 10470380.
    Citations: 2     Fields:    Translation:AnimalsCells
  127. Stossel TP, Hartwig JH, Janmey PA, Kwiatkowski DJ. Cell crawling two decades after Abercrombie. Biochem Soc Symp. 1999; 65:267-80. PMID: 10320944.
    Citations: 7     Fields:    Translation:Cells
  128. McGrath JL, Hartwig JH, Tardy Y, Dewey CF. Measuring actin dynamics in endothelial cells. Microsc Res Tech. 1998 Dec 01; 43(5):385-94. PMID: 9858336.
    Citations: 9     Fields:    Translation:Cells
  129. Geng YJ, Azuma T, Tang JX, Hartwig JH, Muszynski M, Wu Q, Libby P, Kwiatkowski DJ. Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines. Eur J Cell Biol. 1998 Dec; 77(4):294-302. PMID: 9930654.
    Citations: 20     Fields:    Translation:AnimalsCells
  130. McGrath JL, Tardy Y, Dewey CF, Meister JJ, Hartwig JH. Simultaneous measurements of actin filament turnover, filament fraction, and monomer diffusion in endothelial cells. Biophys J. 1998 Oct; 75(4):2070-8. PMID: 9746549.
    Citations: 51     Fields:    Translation:AnimalsCells
  131. Howard TH, Hartwig J, Cunningham C. Lymphocyte-specific protein 1 expression in eukaryotic cells reproduces the morphologic and motile abnormality of NAD 47/89 neutrophils. Blood. 1998 Jun 15; 91(12):4786-95. PMID: 9616178.
    Citations: 8     Fields:    Translation:HumansCells
  132. Azuma T, Witke W, Stossel TP, Hartwig JH, Kwiatkowski DJ. Gelsolin is a downstream effector of rac for fibroblast motility. EMBO J. 1998 Mar 02; 17(5):1362-70. PMID: 9482733.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  133. Liu G, Thomas L, Warren RA, Enns CA, Cunningham CC, Hartwig JH, Thomas G. Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway. J Cell Biol. 1997 Dec 29; 139(7):1719-33. PMID: 9412467.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  134. Ramesh N, Antón IM, Hartwig JH, Geha RS. WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14671-6. PMID: 9405671.
    Citations: 91     Fields:    Translation:HumansCells
  135. Satcher R, Dewey CF, Hartwig JH. Mechanical remodeling of the endothelial surface and actin cytoskeleton induced by fluid flow. Microcirculation. 1997 Dec; 4(4):439-53. PMID: 9431512.
    Citations: 17     Fields:    Translation:AnimalsCells
  136. Hartwig JH, Barkalow K. Polyphosphoinositide synthesis and platelet shape change. Curr Opin Hematol. 1997 Sep; 4(5):351-6. PMID: 9288469.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  137. Derman MP, Toker A, Hartwig JH, Spokes K, Falck JR, Chen CS, Cantley LC, Cantley LG. The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C. J Biol Chem. 1997 Mar 07; 272(10):6465-70. PMID: 9045671.
    Citations: 27     Fields:    Translation:AnimalsCells
  138. Wientjes FB, Segal AW, Hartwig JH. Immunoelectron microscopy shows a clustered distribution of NADPH oxidase components in the human neutrophil plasma membrane. J Leukoc Biol. 1997 Mar; 61(3):303-12. PMID: 9060453.
    Citations: 10     Fields:    Translation:HumansCells
  139. Marti A, Luo Z, Cunningham C, Ohta Y, Hartwig J, Stossel TP, Kyriakis JM, Avruch J. Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells. J Biol Chem. 1997 Jan 31; 272(5):2620-8. PMID: 9006895.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  140. Meyer SC, Zuerbig S, Cunningham CC, Hartwig JH, Bissell T, Gardner K, Fox JE. Identification of the region in actin-binding protein that binds to the cytoplasmic domain of glycoprotein IBalpha. J Biol Chem. 1997 Jan 31; 272(5):2914-9. PMID: 9006936.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  141. Carpenter CL, Tolias KF, Couvillon AC, Hartwig JH. Signal transduction pathways involving the small G proteins rac and Cdc42 and phosphoinositide kinases. Adv Enzyme Regul. 1997; 37:377-90. PMID: 9381982.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  142. Hartwig JH, Kung S, Kovacsovics T, Janmey PA, Cantley LC, Stossel TP, Toker A. D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate. J Biol Chem. 1996 Dec 20; 271(51):32986-93. PMID: 8955143.
    Citations: 20     Fields:    Translation:HumansCells
  143. Barkalow K, Witke W, Kwiatkowski DJ, Hartwig JH. Coordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein. J Cell Biol. 1996 Jul; 134(2):389-99. PMID: 8707824.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  144. Leterrier JF, Käs J, Hartwig J, Vegners R, Janmey PA. Mechanical effects of neurofilament cross-bridges. Modulation by phosphorylation, lipids, and interactions with F-actin. J Biol Chem. 1996 Jun 28; 271(26):15687-94. PMID: 8663092.
    Citations: 37     Fields:    Translation:AnimalsCells
  145. Ohta Y, Hartwig JH. Phosphorylation of actin-binding protein 280 by growth factors is mediated by p90 ribosomal protein S6 kinase. J Biol Chem. 1996 May 17; 271(20):11858-64. PMID: 8662682.
    Citations: 14     Fields:    Translation:AnimalsCells
  146. Cox D, Wessels D, Soll DR, Hartwig J, Condeelis J. Re-expression of ABP-120 rescues cytoskeletal, motility, and phagocytosis defects of ABP-120- Dictyostelium mutants. Mol Biol Cell. 1996 May; 7(5):803-23. PMID: 8744952.
    Citations: 11     Fields:    Translation:AnimalsCells
  147. Kovacsovics TJ, Hartwig JH. Thrombin-induced GPIb-IX centralization on the platelet surface requires actin assembly and myosin II activation. Blood. 1996 Jan 15; 87(2):618-29. PMID: 8555484.
    Citations: 10     Fields:    Translation:HumansCells
  148. Kieffer JD, Plopper G, Ingber DE, Hartwig JH, Kupper TS. Direct binding of F actin to the cytoplasmic domain of the alpha 2 integrin chain in vitro. Biochem Biophys Res Commun. 1995 Dec 14; 217(2):466-74. PMID: 7503723.
    Citations: 10     Fields:    Translation:HumansCells
  149. Toker A, Bachelot C, Chen CS, Falck JR, Hartwig JH, Cantley LC, Kovacsovics TJ. Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase. J Biol Chem. 1995 Dec 08; 270(49):29525-31. PMID: 7493994.
    Citations: 10     Fields:    Translation:Humans
  150. Tardy Y, McGrath JL, Hartwig JH, Dewey CF. Interpreting photoactivated fluorescence microscopy measurements of steady-state actin dynamics. Biophys J. 1995 Nov; 69(5):1674-82. PMID: 8580311.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  151. Hartwig JH, Jugloff LS, De Groot NJ, Grupp SA, Jongstra-Bilen J. The ligand-induced membrane IgM association with the cytoskeletal matrix of B cells is not mediated through the Ig alpha beta heterodimer. J Immunol. 1995 Oct 15;