Harvard Catalyst Profiles

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Toshihiro Shioda, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01ES031139 (BLUMBERG, BRUCE) Sep 16, 2020 - Jun 30, 2025
    Interactions between prenatal obesogen exposure and Total Western diet lead to a transgenerational thrifty phenotype: functional and epigenomic analysis of effects in fat and liver
    Role: Co-Principal Investigator
  2. R21ES024861 (SHIODA, TOSHIHIRO) Sep 30, 2015 - Sep 29, 2017
    Roles of Nuclear Receptors in Generation of Heritable Epimutations in Germ Cells
    Role: Principal Investigator
  3. R01ES023316 (BLUMBERG, BRUCE) Sep 1, 2013 - Apr 30, 2023
    Transgenerational obesity caused by ancestral exposure to obesogens in utero: changes in germline genomic architecture, roles of gonadal somatic cells, and metabolomic analysis of sexual dimorphism
    Role: Co-Principal Investigator
  4. R01CA082230 (SHIODA, TOSHIHIRO) Jul 1, 1999 - Jun 30, 2006
    Functions of MSG1 Family Transcription Activators
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chang RC, Joloya EM, Li Z, Shoucri BM, Shioda T, Blumberg B. miR-223 Plays a Key Role in Obesogen-Enhanced Adipogenesis in Mesenchymal Stem Cells and in Transgenerational Obesity. Endocrinology. 2023 03 13; 164(5). PMID: 36740725.
    Citations:    Fields:    
  2. Pierson Smela MD, Kramme CC, Fortuna PRJ, Adams JL, Su R, Dong E, Kobayashi M, Brixi G, Kavirayuni VS, Tysinger E, Kohman RE, Shioda T, Chatterjee P, Church GM. Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression. Elife. 2023 02 21; 12. PMID: 36803359; PMCID: PMC9943069.
    Citations: 1     Fields:    Translation:HumansCells
  3. Zheng Y, Yan RZ, Sun S, Kobayashi M, Xiang L, Yang R, Goedel A, Kang Y, Xue X, Esfahani SN, Liu Y, Resto Irizarry AM, Wu W, Li Y, Ji W, Niu Y, Chien KR, Li T, Shioda T, Fu J. Single-cell analysis of embryoids reveals lineage diversification roadmaps of early human development. Cell Stem Cell. 2022 09 01; 29(9):1402-1419.e8. PMID: 36055194; PMCID: PMC9499422.
    Citations:    Fields:    Translation:HumansAnimals
  4. Kobayashi M, Kobayashi M, Odajima J, Shioda K, Hwang YS, Sasaki K, Chatterjee P, Kramme C, Kohman RE, Church GM, Loehr AR, Weiss RS, Jüppner H, Gell JJ, Lau CC, Shioda T. Expanding homogeneous culture of human primordial germ cell-like cells maintaining germline features without serum or feeder layers. Stem Cell Reports. 2022 03 08; 17(3):507-521. PMID: 35148847; PMCID: PMC9039862.
    Citations: 2     Fields:    Translation:HumansCells
  5. Taylor JA, Coe BL, Shioda T, Vom Saal FS. The Crowded Uterine Horn Mouse Model for Examining Postnatal Metabolic Consequences of Intrauterine Growth Restriction vs. Macrosomia in Siblings. Metabolites. 2022 Jan 22; 12(2). PMID: 35208177; PMCID: PMC8880550.
    Citations: 1     
  6. Shioda K, Odajima J, Blumberg B, Shioda T. Transgenerational Transcriptomic and DNA Methylome Profiling of Mouse Fetal Testicular Germline and Somatic Cells after Exposure of Pregnant Mothers to Tributyltin, a Potent Obesogen. Metabolites. 2022 Jan 20; 12(2). PMID: 35208169; PMCID: PMC8874857.
  7. Lim J, Ramesh A, Shioda T, Leon Parada K, Luderer U. Sex Differences in Embryonic Gonad Transcriptomes and Benzo[a]pyrene Metabolite Levels After Transplacental Exposure. Endocrinology. 2022 01 01; 163(1). PMID: 34734245; PMCID: PMC8633617.
    Citations: 3     Fields:    Translation:AnimalsCells
  8. Mohajer N, Joloya EM, Seo J, Shioda T, Blumberg B. Epigenetic Transgenerational Inheritance of the Effects of Obesogen Exposure. Front Endocrinol (Lausanne). 2021; 12:787580. PMID: 34975759; PMCID: PMC8716683.
    Citations: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  9. Hu WY, Hu DP, Xie L, Nonn L, Lu R, Abern M, Shioda T, Prins GS. Keratin Profiling by Single-Cell RNA-Sequencing Identifies Human Prostate Stem Cell Lineage Hierarchy and Cancer Stem-Like Cells. Int J Mol Sci. 2021 Jul 28; 22(15). PMID: 34360875.
    Citations: 2     Fields:    Translation:HumansCells
  10. Shioda K, Odajima J, Kobayashi M, Kobayashi M, Cordazzo B, Isselbacher KJ, Shioda T. Transcriptomic and Epigenetic Preservation of Genetic Sex Identity in Estrogen-feminized Male Chicken Embryonic Gonads. Endocrinology. 2021 Jan 01; 162(1). PMID: 33513614.
    Citations:    Fields:    
  11. Shioda K, Odajima J, Kobayashi M, Kobayashi M, Cordazzo B, Isselbacher KJ, Shioda T. Transcriptomic and Epigenetic Preservation of Genetic Sex Identity in Estrogen-feminized Male Chicken Embryonic Gonads. Endocrinology. 2021 Jan 01; 162(1). PMID: 33513616.
    Citations:    Fields:    
  12. Shioda K, Odajima J, Kobayashi M, Kobayashi M, Cordazzo B, Isselbacher KJ, Shioda T. Transcriptomic and Epigenetic Preservation of Genetic Sex Identity in Estrogen-feminized Male Chicken Embryonic Gonads. Endocrinology. 2021 01 01; 162(1). PMID: 33170207; PMCID: PMC7745639.
    Citations: 8     Fields:    Translation:AnimalsCells
  13. Mitsunaga S, Shioda K, Hanna JH, Isselbacher KJ, Shioda T. Production and Analysis of Human Primordial Germ Cell-Like Cells. Methods Mol Biol. 2021; 2195:125-145. PMID: 32852762.
    Citations: 1     Fields:    Translation:HumansCells
  14. Diaz-Castillo C, Chamorro-Garcia R, Shioda T, Blumberg B. Transgenerational Self-Reconstruction of Disrupted Chromatin Organization After Exposure To An Environmental Stressor in Mice. Sci Rep. 2019 09 10; 9(1):13057. PMID: 31506492.
    Citations: 14     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  15. Tajima K, Matsuda S, Yae T, Drapkin BJ, Morris R, Boukhali M, Niederhoffer K, Comaills V, Dubash T, Nieman L, Guo H, Magnus NKC, Dyson N, Shioda T, Haas W, Haber DA, Maheswaran S. SETD1A protects from senescence through regulation of the mitotic gene expression program. Nat Commun. 2019 06 28; 10(1):2854. PMID: 31253781.
    Citations: 19     Fields:    Translation:HumansCells
  16. Sakurai K, Shioda K, Eguchi A, Watanabe M, Miyaso H, Mori C, Shioda T. DNA methylome of human neonatal umbilical cord: Enrichment of differentially methylated regions compared to umbilical cord blood DNA at transcription factor genes involved in body patterning and effects of maternal folate deficiency or children's sex. PLoS One. 2019; 14(5):e0214307. PMID: 31063509; PMCID: PMC6504184.
    Citations: 2     Fields:    Translation:HumansCells
  17. Zheng Y, Comaills V, Burr R, Boulay G, Miyamoto DT, Wittner BS, Emmons E, Sil S, Koulopoulos MW, Broderick KT, Tai E, Rengarajan S, Kulkarni AS, Shioda T, Wu CL, Ramaswamy S, Ting DT, Toner M, Rivera MN, Maheswaran S, Haber DA. COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis. Proc Natl Acad Sci U S A. 2019 03 19; 116(12):5223-5232. PMID: 30819896; PMCID: PMC6431196.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  18. Mitsunaga S, Shioda K, Isselbacher KJ, Hanna JH, Shioda T. Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells. J Vis Exp. 2019 01 11; (143). PMID: 30688291.
    Citations: 4     Fields:    Translation:HumansCells
  19. Taylor JA, Sommerfeld-Sager JM, Meng CX, Nagel SC, Shioda T, Vom Saal FS. Reduced body weight at weaning followed by increased post-weaning growth rate interacts with part-per-trillion fetal serum concentrations of bisphenol A (BPA) to impair glucose tolerance in male mice. PLoS One. 2018; 13(12):e0208846. PMID: 30557361; PMCID: PMC6296512.
    Citations: 5     Fields:    Translation:Animals
  20. Janesick A, Tang W, Shioda T, Blumberg B. RAR? is required for mesodermal gene expression prior to gastrulation in Xenopus. Development. 2018 09 17; 145(18). PMID: 30111657.
    Citations: 6     Fields:    Translation:AnimalsCells
  21. Di Stefano B, Ueda M, Sabri S, Brumbaugh J, Huebner AJ, Sahakyan A, Clement K, Clowers KJ, Erickson AR, Shioda K, Gygi SP, Gu H, Shioda T, Meissner A, Takashima Y, Plath K, Hochedlinger K. Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells. Nat Methods. 2018 09; 15(9):732-740. PMID: 30127506.
    Citations: 38     Fields:    Translation:HumansCells
  22. Shoucri BM, Hung VT, Chamorro-García R, Shioda T, Blumberg B. Retinoid X Receptor Activation During Adipogenesis of Female Mesenchymal Stem Cells Programs a Dysfunctional Adipocyte. Endocrinology. 2018 08 01; 159(8):2863-2883. PMID: 29860300; PMCID: PMC6669823.
    Citations: 29     Fields:    Translation:AnimalsCells
  23. Mitsunaga S, Shioda T. Evolutionarily diverse mechanisms of germline specification among mammals: what about us? Stem Cell Investig. 2018; 5:12. PMID: 29782583; PMCID: PMC5945857.
    Citations: 1     
  24. Aceto N, Bardia A, Wittner BS, Donaldson MC, O'Keefe R, Engstrom A, Bersani F, Zheng Y, Comaills V, Niederhoffer K, Zhu H, Mackenzie O, Shioda T, Sgroi D, Kapur R, Ting DT, Moy B, Ramaswamy S, Toner M, Haber DA, Maheswaran S. AR Expression in Breast Cancer CTCs Associates with Bone Metastases. Mol Cancer Res. 2018 04; 16(4):720-727. PMID: 29453314; PMCID: PMC5882540.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  25. Owa C, Poulin M, Yan L, Shioda T. Technical adequacy of bisulfite sequencing and pyrosequencing for detection of mitochondrial DNA methylation: Sources and avoidance of false-positive detection. PLoS One. 2018; 13(2):e0192722. PMID: 29420656.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  26. Taylor JA, Shioda K, Mitsunaga S, Yawata S, Angle BM, Nagel SC, Vom Saal FS, Shioda T. Prenatal Exposure to Bisphenol A Disrupts Naturally Occurring Bimodal DNA Methylation at Proximal Promoter of fggy, an Obesity-Relevant Gene Encoding a Carbohydrate Kinase, in Gonadal White Adipose Tissues of CD-1 Mice. Endocrinology. 2018 02 01; 159(2):779-794. PMID: 29220483; PMCID: PMC5774244.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  27. Poulin M, Zhou JY, Yan L, Shioda T. Pyrosequencing Methylation Analysis. Methods Mol Biol. 2018; 1856:283-296. PMID: 30178259.
    Citations: 8     Fields:    Translation:HumansCells
  28. Chamorro-Garcia R, Diaz-Castillo C, Shoucri BM, Käch H, Leavitt R, Shioda T, Blumberg B. Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice. Nat Commun. 2017 12 08; 8(1):2012. PMID: 29222412.
    Citations: 58     Fields:    Translation:AnimalsCells
  29. Mitsunaga S, Odajima J, Yawata S, Shioda K, Owa C, Isselbacher KJ, Hanna JH, Shioda T. Relevance of iPSC-derived human PGC-like cells at the surface of embryoid bodies to prechemotaxis migrating PGCs. Proc Natl Acad Sci U S A. 2017 11 14; 114(46):E9913-E9922. PMID: 29087313; PMCID: PMC5699045.
    Citations: 22     Fields:    Translation:HumansCells
  30. Shoucri BM, Martinez ES, Abreo TJ, Hung VT, Moosova Z, Shioda T, Blumberg B. Retinoid X Receptor Activation Alters the Chromatin Landscape To Commit Mesenchymal Stem Cells to the Adipose Lineage. Endocrinology. 2017 10 01; 158(10):3109-3125. PMID: 28977589; PMCID: PMC5659689.
    Citations: 35     Fields:    Translation:AnimalsCells
  31. Choi J, Huebner AJ, Clement K, Walsh RM, Savol A, Lin K, Gu H, Di Stefano B, Brumbaugh J, Kim SY, Sharif J, Rose CM, Mohammad A, Odajima J, Charron J, Shioda T, Gnirke A, Gygi S, Koseki H, Sadreyev RI, Xiao A, Meissner A, Hochedlinger K. Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells. Nature. 2017 08 10; 548(7666):219-223. PMID: 28746311; PMCID: PMC5905676.
    Citations: 102     Fields:    Translation:AnimalsCells
  32. Rheinbay E, Parasuraman P, Grimsby J, Tiao G, Engreitz JM, Kim J, Lawrence MS, Taylor-Weiner A, Rodriguez-Cuevas S, Rosenberg M, Hess J, Stewart C, Maruvka YE, Stojanov P, Cortes ML, Seepo S, Cibulskis C, Tracy A, Pugh TJ, Lee J, Zheng Z, Ellisen LW, Iafrate AJ, Boehm JS, Gabriel SB, Meyerson M, Golub TR, Baselga J, Hidalgo-Miranda A, Shioda T, Bernards A, Lander ES, Getz G. Recurrent and functional regulatory mutations in breast cancer. Nature. 2017 07 06; 547(7661):55-60. PMID: 28658208.
    Citations: 134     Fields:    Translation:HumansCells
  33. Hu WY, Hu DP, Xie L, Li Y, Majumdar S, Nonn L, Hu H, Shioda T, Prins GS. Isolation and functional interrogation of adult human prostate epithelial stem cells at single cell resolution. Stem Cell Res. 2017 08; 23:1-12. PMID: 28651114.
    Citations: 25     Fields:    Translation:HumansCells
  34. Silberstein L, Goncalves KA, Kharchenko PV, Turcotte R, Kfoury Y, Mercier F, Baryawno N, Severe N, Bachand J, Spencer JA, Papazian A, Lee D, Chitteti BR, Srour EF, Hoggatt J, Tate T, Lo Celso C, Ono N, Nutt S, Heino J, Sipilä K, Shioda T, Osawa M, Lin CP, Hu GF, Scadden DT. Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators. Cell Stem Cell. 2016 10 06; 19(4):530-543. PMID: 27524439.
    Citations: 80     Fields:    Translation:AnimalsCells
  35. Miyoshi N, Stel JM, Shioda K, Qu N, Odajima J, Mitsunaga S, Zhang X, Nagano M, Hochedlinger K, Isselbacher KJ, Shioda T. Erasure of DNA methylation, genomic imprints, and epimutations in a primordial germ-cell model derived from mouse pluripotent stem cells. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):9545-50. PMID: 27486249; PMCID: PMC5003264.
    Citations: 19     Fields:    Translation:AnimalsCells
  36. Clark NC, Friel AM, Pru CA, Zhang L, Shioda T, Rueda BR, Peluso JJ, Pru JK. Progesterone receptor membrane component 1 promotes survival of human breast cancer cells and the growth of xenograft tumors. Cancer Biol Ther. 2016; 17(3):262-71. PMID: 26785864; PMCID: PMC4847980.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  37. Miyoshi N, Wittner BS, Shioda K, Hitora T, Ito T, Ramaswamy S, Isselbacher KJ, Sgroi DC, Shioda T. Nodes-and-connections RNAi knockdown screening: identification of a signaling molecule network involved in fulvestrant action and breast cancer prognosis. Oncogenesis. 2015 Oct 19; 4:e172. PMID: 26479444; PMCID: PMC4632093.
  38. Tajima K, Yae T, Javaid S, Tam O, Comaills V, Morris R, Wittner BS, Liu M, Engstrom A, Takahashi F, Black JC, Ramaswamy S, Shioda T, Hammell M, Haber DA, Whetstine JR, Maheswaran S. SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes. Nat Commun. 2015 Sep 23; 6:8257. PMID: 26394836.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  39. Miyamoto DT, Zheng Y, Wittner BS, Lee RJ, Zhu H, Broderick KT, Desai R, Fox DB, Brannigan BW, Trautwein J, Arora KS, Desai N, Dahl DM, Sequist LV, Smith MR, Kapur R, Wu CL, Shioda T, Ramaswamy S, Ting DT, Toner M, Maheswaran S, Haber DA. RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance. Science. 2015 Sep 18; 349(6254):1351-6. PMID: 26383955; PMCID: PMC4872391.
    Citations: 338     Fields:    Translation:HumansAnimalsCells
  40. Sarioglu AF, Aceto N, Kojic N, Donaldson MC, Zeinali M, Hamza B, Engstrom A, Zhu H, Sundaresan TK, Miyamoto DT, Luo X, Bardia A, Wittner BS, Ramaswamy S, Shioda T, Ting DT, Stott SL, Kapur R, Maheswaran S, Haber DA, Toner M. A microfluidic device for label-free, physical capture of circulating tumor cell clusters. Nat Methods. 2015 Jul; 12(7):685-91. PMID: 25984697; PMCID: PMC4490017.
    Citations: 250     Fields:    Translation:HumansCells
  41. Niederst MJ, Sequist LV, Poirier JT, Mermel CH, Lockerman EL, Garcia AR, Katayama R, Costa C, Ross KN, Moran T, Howe E, Fulton LE, Mulvey HE, Bernardo LA, Mohamoud F, Miyoshi N, VanderLaan PA, Costa DB, Jänne PA, Borger DR, Ramaswamy S, Shioda T, Iafrate AJ, Getz G, Rudin CM, Mino-Kenudson M, Engelman JA. RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer. Nat Commun. 2015 Mar 11; 6:6377. PMID: 25758528.
    Citations: 263     Fields:    Translation:HumansCells
  42. Javaid S, Zhang J, Smolen GA, Yu M, Wittner BS, Singh A, Arora KS, Madden MW, Desai R, Zubrowski MJ, Schott BJ, Ting DT, Stott SL, Toner M, Maheswaran S, Shioda T, Ramaswamy S, Haber DA. MAPK7 Regulates EMT Features and Modulates the Generation of CTCs. Mol Cancer Res. 2015 May; 13(5):934-43. PMID: 25678598; PMCID: PMC4433453.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  43. Friel AM, Zhang L, Pru CA, Clark NC, McCallum ML, Blok LJ, Shioda T, Peluso JJ, Rueda BR, Pru JK. Progesterone receptor membrane component 1 deficiency attenuates growth while promoting chemosensitivity of human endometrial xenograft tumors. Cancer Lett. 2015 Jan 28; 356(2 Pt B):434-42. PMID: 25304370.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  44. Ting DT, Wittner BS, Ligorio M, Vincent Jordan N, Shah AM, Miyamoto DT, Aceto N, Bersani F, Brannigan BW, Xega K, Ciciliano JC, Zhu H, MacKenzie OC, Trautwein J, Arora KS, Shahid M, Ellis HL, Qu N, Bardeesy N, Rivera MN, Deshpande V, Ferrone CR, Kapur R, Ramaswamy S, Shioda T, Toner M, Maheswaran S, Haber DA. Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells. Cell Rep. 2014 Sep 25; 8(6):1905-1918. PMID: 25242334; PMCID: PMC4230325.
    Citations: 232     Fields:    Translation:HumansAnimalsCells
  45. Janesick AS, Shioda T, Blumberg B. Transgenerational inheritance of prenatal obesogen exposure. Mol Cell Endocrinol. 2014 Dec; 398(1-2):31-5. PMID: 25218215.
    Citations: 34     Fields:    Translation:HumansPHPublic Health
  46. Aceto N, Bardia A, Miyamoto DT, Donaldson MC, Wittner BS, Spencer JA, Yu M, Pely A, Engstrom A, Zhu H, Brannigan BW, Kapur R, Stott SL, Shioda T, Ramaswamy S, Ting DT, Lin CP, Toner M, Haber DA, Maheswaran S. Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis. Cell. 2014 Aug 28; 158(5):1110-1122. PMID: 25171411; PMCID: PMC4149753.
    Citations: 1014     Fields:    Translation:HumansAnimalsCells
  47. Yu M, Bardia A, Aceto N, Bersani F, Madden MW, Donaldson MC, Desai R, Zhu H, Comaills V, Zheng Z, Wittner BS, Stojanov P, Brachtel E, Sgroi D, Kapur R, Shioda T, Ting DT, Ramaswamy S, Getz G, Iafrate AJ, Benes C, Toner M, Maheswaran S, Haber DA. Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Science. 2014 Jul 11; 345(6193):216-20. PMID: 25013076; PMCID: PMC4358808.
    Citations: 404     Fields:    Translation:HumansAnimalsCells
  48. Dhimolea E, Wadia PR, Murray TJ, Settles ML, Treitman JD, Sonnenschein C, Shioda T, Soto AM. Prenatal exposure to BPA alters the epigenome of the rat mammary gland and increases the propensity to neoplastic development. PLoS One. 2014; 9(7):e99800. PMID: 24988533.
    Citations: 44     Fields:    Translation:AnimalsCells
  49. Galkina EI, Shin A, Coser KR, Shioda T, Kohane IS, Seong IS, Wheeler VC, Gusella JF, Macdonald ME, Lee JM. HD CAGnome: a search tool for huntingtin CAG repeat length-correlated genes. PLoS One. 2014; 9(4):e95556. PMID: 24751919.
    Citations: 1     Fields:    Translation:HumansCells
  50. Liu M, Roth A, Yu M, Morris R, Bersani F, Rivera MN, Lu J, Shioda T, Vasudevan S, Ramaswamy S, Maheswaran S, Diederichs S, Haber DA. The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. Genes Dev. 2013 Dec 01; 27(23):2543-8. PMID: 24298054.
    Citations: 81     Fields:    Translation:HumansCells
  51. Shioda T, Rosenthal NF, Coser KR, Suto M, Phatak M, Medvedovic M, Carey VJ, Isselbacher KJ. Expressomal approach for comprehensive analysis and visualization of ligand sensitivities of xenoestrogen responsive genes. Proc Natl Acad Sci U S A. 2013 Oct 08; 110(41):16508-13. PMID: 24062438.
    Citations: 12     Fields:    Translation:HumansCells
  52. Wadia PR, Cabaton NJ, Borrero MD, Rubin BS, Sonnenschein C, Shioda T, Soto AM. Low-dose BPA exposure alters the mesenchymal and epithelial transcriptomes of the mouse fetal mammary gland. PLoS One. 2013; 8(5):e63902. PMID: 23704952.
    Citations: 38     Fields:    Translation:AnimalsCells
  53. Lee JM, Galkina EI, Levantovsky RM, Fossale E, Anne Anderson M, Gillis T, Srinidhi Mysore J, Coser KR, Shioda T, Zhang B, Furia MD, Derry J, Kohane IS, Seong IS, Wheeler VC, Gusella JF, MacDonald ME. Dominant effects of the Huntington's disease HTT CAG repeat length are captured in gene-expression data sets by a continuous analysis mathematical modeling strategy. Hum Mol Genet. 2013 Aug 15; 22(16):3227-38. PMID: 23595883.
    Citations: 17     Fields:    Translation:HumansCells
  54. Yeh WL, Shioda K, Coser KR, Rivizzigno D, McSweeney KR, Shioda T. Fulvestrant-induced cell death and proteasomal degradation of estrogen receptor a protein in MCF-7 cells require the CSK c-Src tyrosine kinase. PLoS One. 2013; 8(4):e60889. PMID: 23593342.
    Citations: 34     Fields:    Translation:HumansCells
  55. Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR, Lee DH, Myers JP, Shioda T, Soto AM, vom Saal FS, Welshons WV, Zoeller RT. Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology. Reprod Toxicol. 2013 Jul; 38:1-15. PMID: 23411111.
    Citations: 51     Fields:    Translation:HumansAnimals
  56. Corcoran RB, Cheng KA, Hata AN, Faber AC, Ebi H, Coffee EM, Greninger P, Brown RD, Godfrey JT, Cohoon TJ, Song Y, Lifshits E, Hung KE, Shioda T, Dias-Santagata D, Singh A, Settleman J, Benes CH, Mino-Kenudson M, Wong KK, Engelman JA. Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models. Cancer Cell. 2013 Jan 14; 23(1):121-8. PMID: 23245996.
    Citations: 200     Fields:    Translation:HumansAnimals
  57. Taylor JA, Richter CA, Suzuki A, Watanabe H, Iguchi T, Coser KR, Shioda T, vom Saal FS. Dose-related estrogen effects on gene expression in fetal mouse prostate mesenchymal cells. PLoS One. 2012; 7(10):e48311. PMID: 23144751.
    Citations: 10     Fields:    Translation:AnimalsCells
  58. Ellis HL, Shioda K, Rosenthal NF, Coser KR, Shioda T. Masculine epigenetic sex marks of the CYP19A1/aromatase promoter in genetically male chicken embryonic gonads are resistant to estrogen-induced phenotypic sex conversion. Biol Reprod. 2012 Jul; 87(1):23, 1-12. PMID: 22539680.
    Citations: 7     Fields:    Translation:AnimalsCells
  59. Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR, Lee DH, Shioda T, Soto AM, vom Saal FS, Welshons WV, Zoeller RT, Myers JP. Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr Rev. 2012 Jun; 33(3):378-455. PMID: 22419778.
    Citations: 765     Fields:    Translation:HumansAnimalsPHPublic Health
  60. Stadtfeld M, Apostolou E, Ferrari F, Choi J, Walsh RM, Chen T, Ooi SS, Kim SY, Bestor TH, Shioda T, Park PJ, Hochedlinger K. Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet. 2012 Mar 04; 44(4):398-405, S1-2. PMID: 22387999; PMCID: PMC3538378.
    Citations: 147     Fields:    Translation:AnimalsCells
  61. Walker AK, Jacobs RL, Watts JL, Rottiers V, Jiang K, Finnegan DM, Shioda T, Hansen M, Yang F, Niebergall LJ, Vance DE, Tzoneva M, Hart AC, Näär AM. A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell. 2011 Nov 11; 147(4):840-52. PMID: 22035958.
    Citations: 196     Fields:    Translation:HumansAnimalsCells
  62. Fossale E, Seong IS, Coser KR, Shioda T, Kohane IS, Wheeler VC, Gusella JF, MacDonald ME, Lee JM. Differential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative. Hum Mol Genet. 2011 Nov 01; 20(21):4258-67. PMID: 21840924.
    Citations: 17     Fields:    Translation:AnimalsCells
  63. Jacobsen JC, Gregory GC, Woda JM, Thompson MN, Coser KR, Murthy V, Kohane IS, Gusella JF, Seong IS, MacDonald ME, Shioda T, Lee JM. HD CAG-correlated gene expression changes support a simple dominant gain of function. Hum Mol Genet. 2011 Jul 15; 20(14):2846-60. PMID: 21536587.
    Citations: 38     Fields:    Translation:AnimalsCells
  64. MacKenzie CJ, Shioda T. COS-1 cells as packaging host for production of lentiviruses. Curr Protoc Cell Biol. 2011 Mar; Chapter 26:Unit 26.7. PMID: 21400698.
    Citations: 1     Fields:    Translation:AnimalsCells
  65. Ishii Y, Papa L, Bahadur U, Yue Z, Aguirre-Ghiso J, Shioda T, Waxman S, Germain D. Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of the estrogen receptor, which leads to a proapoptotic unfolded protein response. Clin Cancer Res. 2011 Apr 15; 17(8):2292-300. PMID: 21292820.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  66. Dittmer S, Kovacs Z, Yuan SH, Siszler G, Kögl M, Summer H, Geerts A, Golz S, Shioda T, Methner A. TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex. J Cell Sci. 2011 Jan 15; 124(Pt 2):252-60. PMID: 21172805.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  67. Polo JM, Liu S, Figueroa ME, Kulalert W, Eminli S, Tan KY, Apostolou E, Stadtfeld M, Li Y, Shioda T, Natesan S, Wagers AJ, Melnick A, Evans T, Hochedlinger K. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat Biotechnol. 2010 Aug; 28(8):848-55. PMID: 20644536.
    Citations: 579     Fields:    Translation:AnimalsCells
  68. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 2010 Jul 01; 24(13):1403-17. PMID: 20595232.
    Citations: 177     Fields:    Translation:HumansAnimalsCells
  69. Rosenthal NF, Ellis H, Shioda K, Mahoney C, Coser KR, Shioda T. High-throughput applicable genomic sex typing of chicken by TaqMan real-time quantitative polymerase chain reaction. Poult Sci. 2010 Jul; 89(7):1451-6. PMID: 20548072.
    Citations: 5     Fields:    Translation:AnimalsCells
  70. Najafi-Shoushtari SH, Kristo F, Li Y, Shioda T, Cohen DE, Gerszten RE, Näär AM. MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science. 2010 Jun 18; 328(5985):1566-9. PMID: 20466882; PMCID: PMC3840500.
    Citations: 454     Fields:    Translation:HumansAnimalsCells
  71. Stadtfeld M, Apostolou E, Akutsu H, Fukuda A, Follett P, Natesan S, Kono T, Shioda T, Hochedlinger K. Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature. 2010 May 13; 465(7295):175-81. PMID: 20418860.
    Citations: 391     Fields:    Translation:AnimalsCells
  72. Chen L, Shioda T, Coser KR, Lynch MC, Yang C, Schmidt EV. Genome-wide analysis of YY2 versus YY1 target genes. Nucleic Acids Res. 2010 Jul; 38(12):4011-26. PMID: 20215434; PMCID: PMC2896514.
    Citations: 30     Fields:    Translation:HumansCells
  73. Wolfer A, Wittner BS, Irimia D, Flavin RJ, Lupien M, Gunawardane RN, Meyer CA, Lightcap ES, Tamayo P, Mesirov JP, Liu XS, Shioda T, Toner M, Loda M, Brown M, Brugge JS, Ramaswamy S. MYC regulation of a "poor-prognosis" metastatic cancer cell state. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3698-703. PMID: 20133671.
    Citations: 104     Fields:    Translation:Humans
  74. Hayashida T, Takahashi F, Chiba N, Brachtel E, Takahashi M, Godin-Heymann N, Gross KW, Vivanco Md, Wijendran V, Shioda T, Sgroi D, Donahoe PK, Maheswaran S. HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis. Proc Natl Acad Sci U S A. 2010 Jan 19; 107(3):1100-5. PMID: 20080567.
    Citations: 86     Fields:    Translation:Humans
  75. Peluso JJ, Gawkowska A, Liu X, Shioda T, Pru JK. Progesterone receptor membrane component-1 regulates the development and Cisplatin sensitivity of human ovarian tumors in athymic nude mice. Endocrinology. 2009 Nov; 150(11):4846-54. PMID: 19797399.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  76. Coser KR, Wittner BS, Rosenthal NF, Collins SC, Melas A, Smith SL, Mahoney CJ, Shioda K, Isselbacher KJ, Ramaswamy S, Shioda T. Antiestrogen-resistant subclones of MCF-7 human breast cancer cells are derived from a common monoclonal drug-resistant progenitor. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14536-41. PMID: 19706540.
    Citations: 42     Fields:    Translation:HumansCells
  77. Smith SL, Shioda T. Advantages of COS-1 monkey kidney epithelial cells as packaging host for small-volume production of high-quality recombinant lentiviruses. J Virol Methods. 2009 Apr; 157(1):47-54. PMID: 19118578.
    Citations: 6     Fields:    Translation:AnimalsCells
  78. Montagut C, Sharma SV, Shioda T, McDermott U, Ulman M, Ulkus LE, Dias-Santagata D, Stubbs H, Lee DY, Singh A, Drew L, Haber DA, Settleman J. Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res. 2008 Jun 15; 68(12):4853-61. PMID: 18559533.
    Citations: 224     Fields:    Translation:HumansCells
  79. McDermott U, Iafrate AJ, Gray NS, Shioda T, Classon M, Maheswaran S, Zhou W, Choi HG, Smith SL, Dowell L, Ulkus LE, Kuhlmann G, Greninger P, Christensen JG, Haber DA, Settleman J. Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors. Cancer Res. 2008 May 01; 68(9):3389-95. PMID: 18451166.
    Citations: 173     Fields:    Translation:HumansCells
  80. Yang D, Guo J, Divieti P, Shioda T, Bringhurst FR. CBP/p300-interacting protein CITED1 modulates parathyroid hormone regulation of osteoblastic differentiation. Endocrinology. 2008 Apr; 149(4):1728-35. PMID: 18187554; PMCID: PMC2276703.
    Citations: 15     Fields:    Translation:AnimalsCells
  81. Nelson GM, Padera TP, Garkavtsev I, Shioda T, Jain RK. Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells. Neoplasia. 2007 Dec; 9(12):1038-45. PMID: 18084611.
    Citations: 23     Fields:    Translation:HumansCells
  82. Wang Z, Dahiya S, Provencher H, Muir B, Carney E, Coser K, Shioda T, Ma XJ, Sgroi DC. The prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer. Clin Cancer Res. 2007 Nov 01; 13(21):6327-34. PMID: 17975144.
    Citations: 39     Fields:    Translation:HumansCells
  83. Liu H, Nakayama EE, Theodorou I, Nagai Y, Likanonsakul S, Wasi C, Debre P, Iwamoto A, Shioda T. Polymorphisms in CCR5 chemokine receptor gene in Japan. Int J Immunogenet. 2007 Oct; 34(5):325-35. PMID: 17845302.
    Citations: 6     Fields:    Translation:HumansCells
  84. Boyle S, Shioda T, Perantoni AO, de Caestecker M. Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis. Dev Dyn. 2007 Aug; 236(8):2321-30. PMID: 17615577.
    Citations: 51     Fields:    Translation:Animals
  85. Kashiwagi A, DiGirolamo CM, Kanda Y, Niikura Y, Esmon CT, Hansen TR, Shioda T, Pru JK. The postimplantation embryo differentially regulates endometrial gene expression and decidualization. Endocrinology. 2007 Sep; 148(9):4173-84. PMID: 17510242.
    Citations: 31     Fields:    Translation:HumansAnimals
  86. McBryan J, Howlin J, Kenny PA, Shioda T, Martin F. ERalpha-CITED1 co-regulated genes expressed during pubertal mammary gland development: implications for breast cancer prognosis. Oncogene. 2007 Sep 27; 26(44):6406-19. PMID: 17486082.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  87. Song H, Nakayama EE, Likanonsakul S, Wasi C, Iwamoto A, Shioda T. A three-base-deletion polymorphism in the upstream non-coding region of human interleukin 7 (IL-7) gene could enhance levels of IL-7 expression. Int J Immunogenet. 2007 Apr; 34(2):107-13. PMID: 17373935.
    Citations: 3     Fields:    Translation:HumansCells
  88. Yi X, Bouley R, Lin HY, Bechoua S, Sun TX, Del Re E, Shioda T, Raychowdhury MK, Lu HA, Abou-Samra AB, Brown D, Ausiello DA. Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R. Am J Physiol Renal Physiol. 2007 May; 292(5):F1303-13. PMID: 17287200.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  89. Yang C, Trent S, Ionescu-Tiba V, Lan L, Shioda T, Sgroi D, Schmidt EV. Identification of cyclin D1- and estrogen-regulated genes contributing to breast carcinogenesis and progression. Cancer Res. 2006 Dec 15; 66(24):11649-58. PMID: 17178859.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  90. Hur J, Bell DW, Dean KL, Coser KR, Hilario PC, Okimoto RA, Tobey EM, Smith SL, Isselbacher KJ, Shioda T. Regulation of expression of BIK proapoptotic protein in human breast cancer cells: p53-dependent induction of BIK mRNA by fulvestrant and proteasomal degradation of BIK protein. Cancer Res. 2006 Oct 15; 66(20):10153-61. PMID: 17047080.
    Citations: 33     Fields:    Translation:HumansCells
  91. Shioda T, Chesnes J, Coser KR, Zou L, Hur J, Dean KL, Sonnenschein C, Soto AM, Isselbacher KJ. Importance of dosage standardization for interpreting transcriptomal signature profiles: evidence from studies of xenoestrogens. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):12033-8. PMID: 16882715; PMCID: PMC1525050.
    Citations: 32     Fields:    Translation:HumansCells
  92. Shi G, Boyle SC, Sparrow DB, Dunwoodie SL, Shioda T, de Caestecker MP. The transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner. J Biol Chem. 2006 Sep 15; 281(37):27426-35. PMID: 16864582.
    Citations: 10     Fields:    Translation:HumansCells
  93. Howlin J, McBryan J, Napoletano S, Lambe T, McArdle E, Shioda T, Martin F. CITED1 homozygous null mice display aberrant pubertal mammary ductal morphogenesis. Oncogene. 2006 Mar 09; 25(10):1532-42. PMID: 16278680.
    Citations: 21     Fields:    Translation:Animals
  94. Plisov S, Tsang M, Shi G, Boyle S, Yoshino K, Dunwoodie SL, Dawid IB, Shioda T, Perantoni AO, de Caestecker MP. Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning. J Am Soc Nephrol. 2005 Jun; 16(6):1632-44. PMID: 15843474.
    Citations: 30     Fields:    Translation:AnimalsCells
  95. Hur J, Chesnes J, Coser KR, Lee RS, Geck P, Isselbacher KJ, Shioda T. The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2351-6. PMID: 14983013; PMCID: PMC356954.
    Citations: 35     Fields:    Translation:HumansCells
  96. Shioda T. Application of DNA microarray to toxicological research. J Environ Pathol Toxicol Oncol. 2004; 23(1):13-31. PMID: 14994992.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  97. Rodriguez TA, Sparrow DB, Scott AN, Withington SL, Preis JI, Michalicek J, Clements M, Tsang TE, Shioda T, Beddington RS, Dunwoodie SL. Cited1 is required in trophoblasts for placental development and for embryo growth and survival. Mol Cell Biol. 2004 Jan; 24(1):228-44. PMID: 14673158.
    Citations: 31     Fields:    Translation:AnimalsCells
  98. Coser KR, Chesnes J, Hur J, Ray S, Isselbacher KJ, Shioda T. Global analysis of ligand sensitivity of estrogen inducible and suppressible genes in MCF7/BUS breast cancer cells by DNA microarray. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):13994-9. PMID: 14610279; PMCID: PMC283534.
    Citations: 72     Fields:    Translation:HumansCells
  99. Yahata T, Takedatsu H, Dunwoodie SL, Bragança J, Swingler T, Withington SL, Hur J, Coser KR, Isselbacher KJ, Bhattacharya S, Shioda T. Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells. Genomics. 2002 Dec; 80(6):601-13. PMID: 12504852.
    Citations: 18     Fields:    Translation:AnimalsCells
  100. Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S. Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2. J Biol Chem. 2002 Mar 08; 277(10):8559-65. PMID: 11744733.
    Citations: 48     Fields:    Translation:HumansCells
  101. Yahata T, Shao W, Endoh H, Hur J, Coser KR, Sun H, Ueda Y, Kato S, Isselbacher KJ, Brown M, Shioda T. Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein. Genes Dev. 2001 Oct 01; 15(19):2598-612. PMID: 11581164; PMCID: PMC312794.
    Citations: 48     Fields:    Translation:AnimalsCells
  102. Nair SS, Chaubal VA, Shioda T, Coser KR, Mojamdar M. Over-expression of MSG1 transcriptional co-activator increases melanin in B16 melanoma cells: a possible role for MSG1 in melanogenesis. Pigment Cell Res. 2001 Jun; 14(3):206-9. PMID: 11434569.
    Citations: 5     Fields:    Translation:AnimalsCells
  103. Takeuchi K, Komatsu T, Yokoo J, Kato A, Shioda T, Nagai Y, Gotoh B. Sendai virus C protein physically associates with Stat1. Genes Cells. 2001 Jun; 6(6):545-57. PMID: 11442634.
    Citations: 39     Fields:    Translation:HumansCells
  104. Ahmed NU, Shioda T, Coser KR, Ichihashi M, Ueda M. Aberrant expression of MSG1 transcriptional activator in human malignant melanoma in vivo. Pigment Cell Res. 2001 Apr; 14(2):140-3. PMID: 11310794.
    Citations: 2     Fields:    Translation:Humans
  105. Sakuragi J, Shioda T, Panganiban AT. Duplication of the primary encapsidation and dimer linkage region of human immunodeficiency virus type 1 RNA results in the appearance of monomeric RNA in virions. J Virol. 2001 Mar; 75(6):2557-65. PMID: 11222678; PMCID: PMC115878.
    Citations: 37     Fields:    Translation:HumansCells
  106. Sado T, Fenner MH, Tan SS, Tam P, Shioda T, Li E. X inactivation in the mouse embryo deficient for Dnmt1: distinct effect of hypomethylation on imprinted and random X inactivation. Dev Biol. 2000 Sep 15; 225(2):294-303. PMID: 10985851.
    Citations: 77     Fields:    Translation:AnimalsCells
  107. Ohnishi Y, Senda T, Nandhagopal N, Sugimoto K, Shioda T, Nagal Y, Mitsui Y. Crystal structure of recombinant native SDF-1alpha with additional mutagenesis studies: an attempt at a more comprehensive interpretation of accumulated structure-activity relationship data. J Interferon Cytokine Res. 2000 Aug; 20(8):691-700. PMID: 10954912.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  108. Yahata T, Andriole S, Isselbacher KJ, Shioda T. Estimation of baculovirus titer by beta-galactosidase activity assay of virus preparations. Biotechniques. 2000 Aug; 29(2):214-5. PMID: 10948416.
    Citations:    Fields:    Translation:AnimalsCells
  109. Andrews JE, O'Neill MJ, Binder M, Shioda T, Sinclair AH. Isolation and expression of a novel member of the CITED family. Mech Dev. 2000 Jul; 95(1-2):305-8. PMID: 10906483.
    Citations: 6     Fields:    Translation:AnimalsCells
  110. Nakayama EE, Hoshino Y, Xin X, Liu H, Goto M, Watanabe N, Taguchi H, Hitani A, Kawana-Tachikawa A, Fukushima M, Yamada K, Sugiura W, Oka SI, Ajisawa A, Sato H, Takebe Y, Nakamura T, Nagai Y, Iwamoto A, Shioda T. Polymorphism in the interleukin-4 promoter affects acquisition of human immunodeficiency virus type 1 syncytium-inducing phenotype. J Virol. 2000 Jun; 74(12):5452-9. PMID: 10823849; PMCID: PMC112029.
    Citations: 18     Fields:    Translation:HumansCells
  111. Shioda T, Andriole S, Yahata T, Isselbacher KJ. A green fluorescent protein-reporter mammalian two-hybrid system with extrachromosomal maintenance of a prey expression plasmid: application to interaction screening. Proc Natl Acad Sci U S A. 2000 May 09; 97(10):5220-4. PMID: 10805780; PMCID: PMC25809.
    Citations: 11     Fields:    Translation:AnimalsCells
  112. Yahata T, de Caestecker MP, Lechleider RJ, Andriole S, Roberts AB, Isselbacher KJ, Shioda T. The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. J Biol Chem. 2000 Mar 24; 275(12):8825-34. PMID: 10722728.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  113. Shioda T, Wakabayashi M. Effect of certain chemicals on the reproduction of medaka (Oryzias latipes). Chemosphere. 2000 Feb; 40(3):239-43. PMID: 10665413.
    Citations: 7     Fields:    Translation:AnimalsCells
  114. de Caestecker MP, Yahata T, Wang D, Parks WT, Huang S, Hill CS, Shioda T, Roberts AB, Lechleider RJ. The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain. J Biol Chem. 2000 Jan 21; 275(3):2115-22. PMID: 10636916.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  115. Kato A, Kiyotani K, Hasan MK, Shioda T, Sakai Y, Yoshida T, Nagai Y. Sendai virus gene start signals are not equivalent in reinitiation capacity: moderation at the fusion protein gene. J Virol. 1999 Nov; 73(11):9237-46. PMID: 10516032; PMCID: PMC112958.
    Citations: 24     Fields:    Translation:AnimalsCells
  116. Kawana A, Tomiyama H, Takiguchi M, Shioda T, Nakamura T, Iwamoto A. Accumulation of specific amino acid substitutions in HLA-B35-restricted human immunodeficiency virus type 1 cytotoxic T lymphocyte epitopes. AIDS Res Hum Retroviruses. 1999 Aug 10; 15(12):1099-107. PMID: 10461830.
    Citations: 5     Fields:    Translation:HumansCells
  117. Liu H, Chao D, Nakayama EE, Taguchi H, Goto M, Xin X, Takamatsu JK, Saito H, Ishikawa Y, Akaza T, Juji T, Takebe Y, Ohishi T, Fukutake K, Maruyama Y, Yashiki S, Sonoda S, Nakamura T, Nagai Y, Iwamoto A, Shioda T. Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression. Proc Natl Acad Sci U S A. 1999 Apr 13; 96(8):4581-5. PMID: 10200305; PMCID: PMC16375.
    Citations: 102     Fields:    Translation:HumansCells
  118. Wang J, Harada A, Matsushita S, Matsumi S, Zhang Y, Shioda T, Nagai Y, Matsushima K. IL-4 and a glucocorticoid up-regulate CXCR4 expression on human CD4+ T lymphocytes and enhance HIV-1 replication. J Leukoc Biol. 1998 Nov; 64(5):642-9. PMID: 9823770.
    Citations: 22     Fields:    Translation:HumansCells
  119. Takeda M, Kato A, Kobune F, Sakata H, Li Y, Shioda T, Sakai Y, Asakawa M, Nagai Y. Measles virus attenuation associated with transcriptional impediment and a few amino acid changes in the polymerase and accessory proteins. J Virol. 1998 Nov; 72(11):8690-6. PMID: 9765410; PMCID: PMC110282.
    Citations: 41     Fields:    Translation:AnimalsCells
  120. Shioda T, Lechleider RJ, Dunwoodie SL, Li H, Yahata T, de Caestecker MP, Fenner MH, Roberts AB, Isselbacher KJ. Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):9785-90. PMID: 9707553; PMCID: PMC21414.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  121. Li H, Ahmed NU, Fenner MH, Ueda M, Isselbacher KJ, Shioda T. Regulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells. Exp Cell Res. 1998 Aug 01; 242(2):478-86. PMID: 9683535.
    Citations: 8     Fields:    Translation:HumansCells
  122. Fenner MH, Parrish JE, Boyd Y, Reed V, MacDonald M, Nelson DL, Isselbacher KJ, Shioda T. MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis. Genomics. 1998 Aug 01; 51(3):401-7. PMID: 9721210.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  123. Ohtsuki T, Hosono O, Kobayashi H, Munakata Y, Souta A, Shioda T, Morimoto C. Negative regulation of the anti-human immunodeficiency virus and chemotactic activity of human stromal cell-derived factor 1alpha by CD26/dipeptidyl peptidase IV. FEBS Lett. 1998 Jul 17; 431(2):236-40. PMID: 9708910.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  124. Shioda T, Kato H, Ohnishi Y, Tashiro K, Ikegawa M, Nakayama EE, Hu H, Kato A, Sakai Y, Liu H, Honjo T, Nomoto A, Iwamoto A, Morimoto C, Nagai Y. Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1alpha (SDF-1alpha) and SDF-1beta are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6331-6. PMID: 9600965; PMCID: PMC27682.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  125. Moriya C, Shioda T, Tashiro K, Nagasawa T, Ikegawa M, Ohnishi Y, Kato A, Hu H, Xin X, Hasan MK, Maekawa M, Takebe Y, Sakai Y, Honjo T, Nagai Y. Large quantity production with extreme convenience of human SDF-1alpha and SDF-1beta by a Sendai virus vector. FEBS Lett. 1998 Mar 20; 425(1):105-11. PMID: 9541016.
    Citations: 2     Fields:    Translation:HumansCells
  126. Kurotani A, Kiyotani K, Kato A, Shioda T, Sakai Y, Mizumoto K, Yoshida T, Nagai Y. Sendai virus C proteins are categorically nonessential gene products but silencing their expression severely impairs viral replication and pathogenesis. Genes Cells. 1998 Feb; 3(2):111-24. PMID: 9605405.
    Citations: 53     Fields:    Translation:AnimalsCells
  127. Hu H, Shioda T, Hori T, Moriya C, Kato A, Sakai Y, Matsushima K, Uchiyama T, Nagai Y. Dissociation of ligand-induced internalization of CXCR-4 from its co-receptor activity for HIV-1 Env-mediated membrane fusion. Arch Virol. 1998; 143(5):851-61. PMID: 9645193.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  128. Xin X, Shioda T, Fukushima M, Hu H, Oka S, Iwamoto A, Nagai Y. Facilitation of HIV-1 isolation from patients by neuraminidase. Arch Virol. 1998; 143(1):85-95. PMID: 9505968.
    Citations: 2     Fields:    Translation:HumansCells
  129. Shioda T, Fenner MH, Isselbacher KJ. MSG1 and its related protein MRG1 share a transcription activating domain. Gene. 1997 Dec 19; 204(1-2):235-41. PMID: 9434189.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  130. Ida S, Gatanaga H, Shioda T, Nagai Y, Kobayashi N, Shimada K, Kimura S, Iwamoto A, Oka S. HIV type 1 V3 variation dynamics in vivo: long-term persistence of non-syncytium-inducing genotypes and transient presence of syncytium-inducing genotypes during the course of progressive AIDS. AIDS Res Hum Retroviruses. 1997 Dec 10; 13(18):1597-609. PMID: 9430252.
    Citations: 15     Fields:    Translation:HumansCells
  131. Hasan MK, Kato A, Shioda T, Sakai Y, Yu D, Nagai Y. Creation of an infectious recombinant Sendai virus expressing the firefly luciferase gene from the 3' proximal first locus. J Gen Virol. 1997 Nov; 78 ( Pt 11):2813-20. PMID: 9367367.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  132. Kato A, Kiyotani K, Sakai Y, Yoshida T, Shioda T, Nagai Y. Importance of the cysteine-rich carboxyl-terminal half of V protein for Sendai virus pathogenesis. J Virol. 1997 Oct; 71(10):7266-72. PMID: 9311801; PMCID: PMC192068.
    Citations: 37     Fields:    Translation:AnimalsCells
  133. Shioda T, Oka S, Xin X, Liu H, Harukuni R, Kurotani A, Fukushima M, Hasan MK, Shiino T, Takebe Y, Iwamoto A, Nagai Y. In vivo sequence variability of human immunodeficiency virus type 1 envelope gp120: association of V2 extension with slow disease progression. J Virol. 1997 Jul; 71(7):4871-81. PMID: 9188549; PMCID: PMC191717.
    Citations: 35     Fields:    Translation:HumansCells
  134. Shiraki K, Tsuji N, Shioda T, Isselbacher KJ, Takahashi H. Expression of Fas ligand in liver metastases of human colonic adenocarcinomas. Proc Natl Acad Sci U S A. 1997 Jun 10; 94(12):6420-5. PMID: 9177233; PMCID: PMC21065.
    Citations: 55     Fields:    Translation:HumansCells
  135. Shioda T, Munn LL, Fenner MH, Jain RK, Isselbacher KJ. Early events of metastasis in the microcirculation involve changes in gene expression of cancer cells. Tracking mRNA levels of metastasizing cancer cells in the chick embryo chorioallantoic membrane. Am J Pathol. 1997 Jun; 150(6):2099-112. PMID: 9176401; PMCID: PMC1858325.
    Citations: 8     Fields:    Translation:AnimalsCells
  136. Shioda T, Fenner MH, Isselbacher KJ. Experimental animal model of hematogenous cardiac metastasis and neoplastic cardiac tamponade. J Surg Oncol. 1997 Feb; 64(2):122-6. PMID: 9047248.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  137. Hu H, Shioda T, Moriya C, Xin X, Hasan MK, Miyake K, Shimada T, Nagai Y. Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface. J Virol. 1996 Nov; 70(11):7462-70. PMID: 8892864; PMCID: PMC190813.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  138. Shioda T, Fenner MH, Isselbacher KJ. msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12298-303. PMID: 8901575; PMCID: PMC37985.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  139. Kato A, Sakai Y, Shioda T, Kondo T, Nakanishi M, Nagai Y. Initiation of Sendai virus multiplication from transfected cDNA or RNA with negative or positive sense. Genes Cells. 1996 Jun; 1(6):569-79. PMID: 9078386.
    Citations: 93     Fields:    Translation:Cells
  140. Takagi T, Muroya K, Iwama M, Shioda T, Tsukamoto T, Mizumoto K. In vitro mRNA synthesis by Sendai virus: isolation and characterization of the transcription initiation complex. J Biochem. 1995 Aug; 118(2):390-6. PMID: 8543575.
    Citations: 6     Fields:    Translation:AnimalsCells
  141. Shioda T, Ohta T, Isselbacher KJ, Rhoads DB. Differentiation-dependent expression of the Na+/glucose cotransporter (SGLT1) in LLC-PK1 cells: role of protein kinase C activation and ongoing transcription. Proc Natl Acad Sci U S A. 1994 Dec 06; 91(25):11919-23. PMID: 7991557; PMCID: PMC45347.
    Citations: 5     Fields:    Translation:AnimalsCells
  142. Shioda T, Oka S, Ida S, Nokihara K, Toriyoshi H, Mori S, Takebe Y, Kimura S, Shimada K, Nagai Y, et al. A naturally occurring single basic amino acid substitution in the V3 region of the human immunodeficiency virus type 1 env protein alters the cellular host range and antigenic structure of the virus. J Virol. 1994 Dec; 68(12):7689-96. PMID: 7966558; PMCID: PMC237229.
    Citations: 22     Fields:    Translation:HumansCells
  143. Oka S, Ida S, Shioda T, Takebe Y, Kobayashi N, Shibuya Y, Ohyama K, Momota K, Kimura S, Shimada K. Genetic analysis of HIV-1 during rapid progression to AIDS in an apparently healthy man. AIDS Res Hum Retroviruses. 1994 Mar; 10(3):271-7. PMID: 8018387.
    Citations: 9     Fields:    Translation:HumansCells
  144. LeGuern M, Shioda T, Levy JA, Cheng-Mayer C. Single amino acid change in Tat determines the different rates of replication of two sequential HIV-1 isolates. Virology. 1993 Aug; 195(2):441-7. PMID: 8337822.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  145. Cheng-Mayer C, Shioda T, Levy JA. Host range, replicative, and cytopathic properties of human immunodeficiency virus type 1 are determined by very few amino acid changes in tat and gp120. J Virol. 1991 Dec; 65(12):6931-41. PMID: 1658383; PMCID: PMC250799.
    Citations: 63     Fields:    Translation:HumansCells
  146. Aoki N, Shioda T, Satoh H, Shibuta H. Syncytium formation of human and non-human cells by recombinant vaccinia viruses carrying the HIV env gene and human CD4 gene. AIDS. 1991 Jul; 5(7):871-5. PMID: 1909875.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  147. Shioda T, Levy JA, Cheng-Mayer C. Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene. Nature. 1991 Jan 10; 349(6305):167-9. PMID: 1986308.
    Citations: 242     Fields:    Translation:HumansCells
  148. Yoshikawa Y, Tsuruoka H, Matsumoto M, Haga T, Shioda T, Shibuta H, Sato TA, Yamanouchi K. Molecular analysis of structural protein genes of the Yamagata-1 strain of defective subacute sclerosing panencephalitis virus. II. Nucleotide sequence of a cDNA corresponding to the P plus M dicistronic mRNA. Virus Genes. 1990 Jul; 4(2):151-61. PMID: 1698326.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  149. Shioda T, Wakao S, Suzu S, Shibuta H. Differences in bovine parainfluenza 3 virus variants studied by sequencing of the genes of viral envelope proteins. Virology. 1988 Feb; 162(2):388-96. PMID: 2829426.
    Citations: 9     Fields:    Translation:AnimalsCells
  150. Sakai Y, Suzu S, Shioda T, Shibuta H. Nucleotide sequence of the bovine parainfluenza 3 virus genome: its 3' end and the genes of NP, P, C and M proteins. Nucleic Acids Res. 1987 Apr 10; 15(7):2927-44. PMID: 3031614; PMCID: PMC340707.
    Citations: 22     Fields:    Translation:AnimalsCells
  151. Suzu S, Sakai Y, Shioda T, Shibuta H. Nucleotide sequence of the bovine parainfluenza 3 virus genome: the genes of the F and HN glycoproteins. Nucleic Acids Res. 1987 Apr 10; 15(7):2945-58. PMID: 3031615; PMCID: PMC340708.
    Citations: 12     Fields:    Translation:AnimalsCells
  152. Shioda T, Iwasaki K, Shibuta H. Determination of the complete nucleotide sequence of the Sendai virus genome RNA and the predicted amino acid sequences of the F, HN and L proteins. Nucleic Acids Res. 1986 Feb 25; 14(4):1545-63. PMID: 3005975; PMCID: PMC339528.
    Citations: 55     Fields:    Translation:Cells
  153. Hidaka Y, Kanda T, Iwasaki K, Nomoto A, Shioda T, Shibuta H. Nucleotide sequence of a Sendai virus genome region covering the entire M gene and the 3' proximal 1013 nucleotides of the F gene. Nucleic Acids Res. 1984 Nov 12; 12(21):7965-73. PMID: 6095182; PMCID: PMC320259.
    Citations: 17     Fields:    Translation:AnimalsCells
  154. Shioda T, Hidaka Y, Kanda T, Shibuta H, Nomoto A, Iwasaki K. Sequence of 3,687 nucleotides from the 3' end of Sendai virus genome RNA and the predicted amino acid sequences of viral NP, P and C proteins. Nucleic Acids Res. 1983 Nov 11; 11(21):7317-30. PMID: 6316257; PMCID: PMC326485.
    Citations: 68     Fields:    Translation:Cells
  155. Shibuta H, Nozawa A, Shioda T, Kanda T. Neuraminidase activity and syncytial formation in variants of parainfluenza 3 virus. Infect Immun. 1983 Aug; 41(2):780-8. PMID: 6307881.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.