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Leona Adrienne Doyle, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ritterhouse LL, Wu EY, Kim WG, Dillon DA, Hirsch MS, Sholl LM, Agoston AT, Setia N, Lauwers GY, Park DY, Srivastava A, Doyle LA. Loss of SMAD4 protein expression in gastrointestinal and extra-gastrointestinal carcinomas. Histopathology. 2019 Oct; 75(4):546-551. PMID: 31054158.
    Citations:    Fields:    Translation:Humans
  2. Doyle LA, Nowak JA, Nathenson MJ, Thornton K, Wagner AJ, Johnson JM, Albrayak A, George S, Sholl LM. Characteristics of mismatch repair deficiency in sarcomas. Mod Pathol. 2019 07; 32(7):977-987. PMID: 30765880.
    Citations: 4     Fields:    Translation:HumansCells
  3. Mito JK, Mitra D, Barysauskas CM, Mariño-Enriquez A, Morgan EA, Fletcher CDM, Raut CP, Baldini EH, Doyle LA. A Comparison of Outcomes and Prognostic Features for Radiation-Associated Angiosarcoma of the Breast and Other Radiation-Associated Sarcomas. Int J Radiat Oncol Biol Phys. 2019 06 01; 104(2):425-435. PMID: 30703514.
    Citations: 1     Fields:    Translation:Humans
  4. DeFilippis EM, Nohria A, Burstein HJ, Doyle LA, Miller AL, Loscalzo J. A Breath-Taking Diagnosis. N Engl J Med. 2019 01 03; 380(1):81-87. PMID: 30601740.
    Citations: 2     Fields:    Translation:Humans
  5. Mito JK, Mitra D, Doyle LA. Radiation-Associated Sarcomas: An Update on Clinical, Histologic, and Molecular Features. Surg Pathol Clin. 2019 Mar; 12(1):139-148. PMID: 30709440.
    Citations: 2     Fields:    Translation:Humans
  6. Elias KM, Tsantoulis P, Tille JC, Vitonis A, Doyle LA, Hornick JL, Kaya G, Barnes L, Cramer DW, Puppa G, Stuckelberger S, Hooda J, Dietrich PY, Goggins M, Kerr CL, Birrer M, Hirsch MS, Drapkin R, Labidi-Galy SI. Primordial germ cells as a potential shared cell of origin for mucinous cystic neoplasms of the pancreas and mucinous ovarian tumors. J Pathol. 2018 12; 246(4):459-469. PMID: 30229909.
    Citations: 3     Fields:    Translation:HumansCells
  7. Yurgelun MB, Chittenden AB, Morales-Oyarvide V, Rubinson DA, Dunne RF, Kozak MM, Qian ZR, Welch MW, Brais LK, Da Silva A, Bui JL, Yuan C, Li T, Li W, Masuda A, Gu M, Bullock AJ, Chang DT, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Thorner AR, Ducar MD, Wollison BM, Khalaf N, Perez K, Syngal S, Aguirre AJ, Hahn WC, Meyerson ML, Fuchs CS, Ogino S, Hornick JL, Hezel AF, Koong AC, Nowak JA, Wolpin BM. Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer. Genet Med. 2019 01; 21(1):213-223. PMID: 29961768.
    Citations: 18     Fields:    Translation:Humans
  8. Aguirre AJ, Nowak JA, Camarda ND, Moffitt RA, Ghazani AA, Hazar-Rethinam M, Raghavan S, Kim J, Brais LK, Ragon D, Welch MW, Reilly E, McCabe D, Marini L, Anderka K, Helvie K, Oliver N, Babic A, Da Silva A, Nadres B, Van Seventer EE, Shahzade HA, St Pierre JP, Burke KP, Clancy T, Cleary JM, Doyle LA, Jajoo K, McCleary NJ, Meyerhardt JA, Murphy JE, Ng K, Patel AK, Perez K, Rosenthal MH, Rubinson DA, Ryou M, Shapiro GI, Sicinska E, Silverman SG, Nagy RJ, Lanman RB, Knoerzer D, Welsch DJ, Yurgelun MB, Fuchs CS, Garraway LA, Getz G, Hornick JL, Johnson BE, Kulke MH, Mayer RJ, Miller JW, Shyn PB, Tuveson DA, Wagle N, Yeh JJ, Hahn WC, Corcoran RB, Carter SL, Wolpin BM. Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine. Cancer Discov. 2018 09; 8(9):1096-1111. PMID: 29903880.
    Citations: 20     Fields:    Translation:HumansCells
  9. Qian ZR, Rubinson DA, Nowak JA, Morales-Oyarvide V, Dunne RF, Kozak MM, Welch MW, Brais LK, Da Silva A, Li T, Li W, Masuda A, Yang J, Shi Y, Gu M, Masugi Y, Bui J, Zellers CL, Yuan C, Babic A, Khalaf N, Aguirre A, Ng K, Miksad RA, Bullock AJ, Chang DT, Tseng JF, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Thorner AR, Ducar M, Wollison B, Laing A, Hahn WC, Meyerson M, Fuchs CS, Ogino S, Hornick JL, Hezel AF, Koong AC, Wolpin BM. Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma. JAMA Oncol. 2018 Mar 08; 4(3):e173420. PMID: 29098284.
    Citations: 17     Fields:    Translation:Humans
  10. Coy S, Doyle LA. Fumarate hydratase expression is retained in atypical intradermal smooth muscle neoplasms and cutaneous leiomyosarcomas. Histopathology. 2017 12; 71(6):1023-1025. PMID: 28703412.
    Citations:    Fields:    Translation:Humans
  11. Morales-Oyarvide V, Rubinson DA, Dunne RF, Kozak MM, Bui JL, Yuan C, Qian ZR, Babic A, Da Silva A, Nowak JA, Khalaf N, Brais LK, Welch MW, Zellers CL, Ng K, Chang DT, Miksad RA, Bullock AJ, Tseng JF, Swanson RS, Clancy TE, Linehan DC, Findeis-Hosey JJ, Doyle LA, Hornick JL, Ogino S, Fuchs CS, Hezel AF, Koong AC, Wolpin BM. Lymph node metastases in resected pancreatic ductal adenocarcinoma: predictors of disease recurrence and survival. Br J Cancer. 2017 Dec 05; 117(12):1874-1882. PMID: 28982112.
    Citations: 11     Fields:    Translation:Humans
  12. Mito JK, Qian X, Doyle LA, Hornick JL, Jo VY. Role of Histone H3K27 Trimethylation Loss as a Marker for Malignant Peripheral Nerve Sheath Tumor in Fine-Needle Aspiration and Small Biopsy Specimens. Am J Clin Pathol. 2017 Aug 01; 148(2):179-189. PMID: 28898989.
    Citations:    Fields:    Translation:HumansCells
  13. Conner JR, Mariño-Enríquez A, Mino-Kenudson M, Garcia E, Pitman MB, Sholl LM, Srivastava A, Doyle LA. Genomic Characterization of Low- and High-Grade Pancreatic Mucinous Cystic Neoplasms Reveals Recurrent KRAS Alterations in "High-Risk" Lesions. Pancreas. 2017 May/Jun; 46(5):665-671. PMID: 28196015.
    Citations:    Fields:    Translation:Humans
  14. Compton LA, Doyle LA. Advances in the Genetic Characterization of Cutaneous Mesenchymal Neoplasms: Implications for Tumor Classification and Novel Diagnostic Markers. Surg Pathol Clin. 2017 Jun; 10(2):299-317. PMID: 28477882.
    Citations:    Fields:    Translation:Humans
  15. Schaefer IM, Wang Y, Liang CW, Bahri N, Quattrone A, Doyle L, Mariño-Enríquez A, Lauria A, Zhu M, Debiec-Rychter M, Grunewald S, Hechtman JF, Dufresne A, Antonescu CR, Beadling C, Sicinska ET, van de Rijn M, Demetri GD, Ladanyi M, Corless CL, Heinrich MC, Raut CP, Bauer S, Fletcher JA. MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation. Nat Commun. 2017 03 08; 8:14674. PMID: 28270683.
    Citations: 12     Fields:    Translation:HumansCells
  16. Ud Din N, Zhang P, Sukov WR, Sattler CA, Jenkins SM, Doyle LA, Folpe AL, Fritchie KJ. Spindle Cell Lipomas Arising at Atypical Locations. Am J Clin Pathol. 2016 Oct; 146(4):487-95. PMID: 27686175.
    Citations: 2     Fields:    Translation:Humans
  17. Jo VY, Doyle LA. Refinements in Sarcoma Classification in the Current 2013 World Health Organization Classification of Tumours of Soft Tissue and Bone. Surg Oncol Clin N Am. 2016 10; 25(4):621-43. PMID: 27591490.
    Citations: 26     Fields:    Translation:Humans
  18. Goyal A, Solus JF, Chan MP, Doyle LA, Schaffer A, Thakuria M, Horn TD, Duncan LM, Nazarian RM. Cytokeratin 17 is highly sensitive in discriminating cutaneous lymphadenoma (a distinct trichoblastoma variant) from basal cell carcinoma. J Cutan Pathol. 2016 May; 43(5):422-9. PMID: 26968559.
    Citations:    Fields:    Translation:Humans
  19. Costigan DC, Doyle LA. Advances in the clinicopathological and molecular classification of cutaneous mesenchymal neoplasms. Histopathology. 2016 May; 68(6):776-95. PMID: 26763770.
    Citations: 4     Fields:    Translation:Humans
  20. Doyle LA, Fletcher CD, Hornick JL. Nuclear Expression of CAMTA1 Distinguishes Epithelioid Hemangioendothelioma From Histologic Mimics. Am J Surg Pathol. 2016 Jan; 40(1):94-102. PMID: 26414223.
    Citations: 20     Fields:    Translation:HumansCells
  21. Matalon SA, Mamon HJ, Fuchs CS, Doyle LA, Tirumani SH, Ramaiya NH, Rosenthal MH. Anorectal Cancer: Critical Anatomic and Staging Distinctions That Affect Use of Radiation Therapy. Radiographics. 2015 Nov-Dec; 35(7):2090-107. PMID: 26562239.
    Citations: 8     Fields:    Translation:HumansCells
  22. Doyle LA. Non-mesenchymal Mimics of Sarcoma. Surg Pathol Clin. 2015 Sep; 8(3):493-513. PMID: 26297067.
    Citations:    Fields:    Translation:Humans
  23. Doyle LA, Fritchie KJ. Diagnostic Challenges and Recent Developments in Soft Tissue Pathology. Preface. Surg Pathol Clin. 2015 Sep; 8(3):ix. PMID: 26297070.
    Citations:    Fields:    Translation:Humans
  24. Johncilla M, Misdraji J, Pratt DS, Agoston AT, Lauwers GY, Srivastava A, Doyle LA. Ipilimumab-associated Hepatitis: Clinicopathologic Characterization in a Series of 11 Cases. Am J Surg Pathol. 2015 Aug; 39(8):1075-84. PMID: 26034866.
    Citations: 30     Fields:    Translation:Humans
  25. Walther C, Hofvander J, Nilsson J, Magnusson L, Domanski HA, Gisselsson D, Tayebwa J, Doyle LA, Fletcher CD, Mertens F. Gene fusion detection in formalin-fixed paraffin-embedded benign fibrous histiocytomas using fluorescence in situ hybridization and RNA sequencing. Lab Invest. 2015 Sep; 95(9):1071-6. PMID: 26121314.
    Citations: 9     Fields:    Translation:Humans
  26. Yang EJ, Quick MC, Hanamornroongruang S, Lai K, Doyle LA, McKeon FD, Xian W, Crum CP, Herfs M. Microanatomy of the cervical and anorectal squamocolumnar junctions: a proposed model for anatomical differences in HPV-related cancer risk. Mod Pathol. 2015 Jul; 28(7):994-1000. PMID: 25975286.
    Citations: 20     Fields:    Translation:Humans
  27. Doyle LA, Mariño-Enriquez A, Fletcher CD, Hornick JL. ALK rearrangement and overexpression in epithelioid fibrous histiocytoma. Mod Pathol. 2015 Jul; 28(7):904-12. PMID: 25857825.
    Citations: 9     Fields:    Translation:HumansCells
  28. Doyle LA. Soft tissue tumor pathology: New diagnostic immunohistochemical markers. Semin Diagn Pathol. 2015 Sep; 32(5):370-80. PMID: 25726492.
    Citations: 1     Fields:    Translation:Humans
  29. Lin G, Doyle LA. An update on the application of newly described immunohistochemical markers in soft tissue pathology. Arch Pathol Lab Med. 2015 Jan; 139(1):106-21. PMID: 25549147.
    Citations: 4     Fields:    Translation:Humans
  30. Lee LS, Doyle LA, Houghton J, Sah S, Bellizzi AM, Szafranska-Schwarzbach AE, Conner JR, Kadiyala V, Suleiman SL, Banks PA, Andruss BF, Conwell DL. Differential expression of GNAS and KRAS mutations in pancreatic cysts. JOP. 2014 Nov 28; 15(6):581-6. PMID: 25435574.
    Citations: 7     Fields:    
  31. Doyle LA, Wong KK, Bueno R, Dal Cin P, Fletcher JA, Sholl LM, Kuo F. Ewing sarcoma mimicking atypical carcinoid tumor: detection of unexpected genomic alterations demonstrates the use of next generation sequencing as a diagnostic tool. Cancer Genet. 2014 Jul-Aug; 207(7-8):335-9. PMID: 25441687.
    Citations: 5     Fields:    Translation:Humans
  32. Doyle LA, Sepehr GJ, Hamilton MJ, Akin C, Castells MC, Hornick JL. A clinicopathologic study of 24 cases of systemic mastocytosis involving the gastrointestinal tract and assessment of mucosal mast cell density in irritable bowel syndrome and asymptomatic patients. Am J Surg Pathol. 2014 Jun; 38(6):832-43. PMID: 24618605.
    Citations: 11     Fields:    Translation:HumansCells
  33. Doyle LA, Hornick JL. Pathology of extramedullary mastocytosis. Immunol Allergy Clin North Am. 2014 May; 34(2):323-39. PMID: 24745677.
    Citations:    Fields:    Translation:HumansCells
  34. Charli-Joseph Y, Saggini A, Doyle LA, Fletcher CD, Weier J, Mirza S, Vemula S, LeBoit PE. DNA copy number changes in tumors within the spectrum of cellular, atypical, and metastasizing fibrous histiocytoma. J Am Acad Dermatol. 2014 Aug; 71(2):256-63. PMID: 24755122.
    Citations: 1     Fields:    Translation:HumansCells
  35. Vivero M, Doyle LA, Fletcher CD, Mertens F, Hornick JL. GRIA2 is a novel diagnostic marker for solitary fibrous tumour identified through gene expression profiling. Histopathology. 2014 Jul; 65(1):71-80. PMID: 24456377.
    Citations: 4     Fields:    Translation:HumansCells
  36. Doyle LA. Sarcoma classification: an update based on the 2013 World Health Organization Classification of Tumors of Soft Tissue and Bone. Cancer. 2014 Jun 15; 120(12):1763-74. PMID: 24648013.
    Citations: 77     Fields:    Translation:Humans
  37. Lee LS, Szafranska-Schwarzbach AE, Wylie D, Doyle LA, Bellizzi AM, Kadiyala V, Suleiman S, Banks PA, Andruss BF, Conwell DL. Investigating MicroRNA Expression Profiles in Pancreatic Cystic Neoplasms. Clin Transl Gastroenterol. 2014 Jan 30; 5:e47. PMID: 24476997.
    Citations: 15     Fields:    
  38. Doyle LA, Tao D, Mariño-Enríquez A. STAT6 is amplified in a subset of dedifferentiated liposarcoma. Mod Pathol. 2014 Sep; 27(9):1231-7. PMID: 24457460.
    Citations: 16     Fields:    Translation:Humans
  39. Nazarian RM, Primiani A, Doyle LA, Linskey KR, Duncan LM, Odze RD, Zukerberg LR. Cytokeratin 17: an adjunctive marker of invasion in squamous neoplastic lesions of the anus. Am J Surg Pathol. 2014 Jan; 38(1):78-85. PMID: 24335642.
    Citations: 3     Fields:    Translation:Humans
  40. Doyle LA, Fletcher CD. Peripheral hemangioblastoma: clinicopathologic characterization in a series of 22 cases. Am J Surg Pathol. 2014 Jan; 38(1):119-27. PMID: 24145646.
    Citations: 10     Fields:    Translation:Humans
  41. Elias KM, Labidi-Galy SI, Vitonis AF, Hornick JL, Doyle LA, Hirsch MS, Cramer DW, Drapkin R. Prior appendectomy does not protect against subsequent development of malignant or borderline mucinous ovarian neoplasms. Gynecol Oncol. 2014 Feb; 132(2):328-33. PMID: 24342438.
    Citations: 2     Fields:    Translation:Humans
  42. Doyle LA, Hornick JL, Fletcher CD. PEComa of the gastrointestinal tract: clinicopathologic study of 35 cases with evaluation of prognostic parameters. Am J Surg Pathol. 2013 Dec; 37(12):1769-82. PMID: 24061520.
    Citations: 15     Fields:    Translation:Humans
  43. Doyle LA, Hornick JL. Gastrointestinal stromal tumours: from KIT to succinate dehydrogenase. Histopathology. 2014 Jan; 64(1):53-67. PMID: 24117705.
    Citations: 13     Fields:    Translation:Humans
  44. Doyle LA, Hornick JL. EWSR1 rearrangements in sclerosing epithelioid fibrosarcoma. Am J Surg Pathol. 2013 Oct; 37(10):1630-1. PMID: 24025527.
    Citations: 2     Fields:    Translation:Humans
  45. Doyle LA, Fletcher CD. Predicting behavior of solitary fibrous tumor: are we getting closer to more accurate risk assessment? Ann Surg Oncol. 2013 Dec; 20(13):4055-6. PMID: 24048700.
    Citations: 3     Fields:    Translation:Humans
  46. Doyle LA, Vivero M, Fletcher CD, Mertens F, Hornick JL. Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics. Mod Pathol. 2014 Mar; 27(3):390-5. PMID: 24030747.
    Citations: 93     Fields:    Translation:HumansCells
  47. Doyle LA, Hornick JL. Mesenchymal Tumors of the Gastrointestinal Tract Other than GIST. Surg Pathol Clin. 2013 Sep; 6(3):425-73. PMID: 26839096.
    Citations: 1     Fields:    
  48. Doyle LA, Fletcher CD. Metastasizing "benign" cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases. Am J Surg Pathol. 2013 Apr; 37(4):484-95. PMID: 23426120.
    Citations: 12     Fields:    Translation:Humans
  49. Doyle LA, Wang WL, Dal Cin P, Lopez-Terrada D, Mertens F, Lazar AJ, Fletcher CD, Hornick JL. MUC4 is a sensitive and extremely useful marker for sclerosing epithelioid fibrosarcoma: association with FUS gene rearrangement. Am J Surg Pathol. 2012 Oct; 36(10):1444-51. PMID: 22982887.
    Citations: 20     Fields:    Translation:HumansCells
  50. Wagner AJ, Remillard SP, Zhang YX, Doyle LA, George S, Hornick JL. Loss of expression of SDHA predicts SDHA mutations in gastrointestinal stromal tumors. Mod Pathol. 2013 Feb; 26(2):289-94. PMID: 22955521.
    Citations: 28     Fields:    Translation:Humans
  51. Doyle LA, Nelson D, Heinrich MC, Corless CL, Hornick JL. Loss of succinate dehydrogenase subunit B (SDHB) expression is limited to a distinctive subset of gastric wild-type gastrointestinal stromal tumours: a comprehensive genotype-phenotype correlation study. Histopathology. 2012 Nov; 61(5):801-9. PMID: 22804613.
    Citations: 21     Fields:    Translation:Humans
  52. Klempner SJ, Choueiri TK, Yee E, Doyle LA, Schuppan D, Atkins MB. Severe pazopanib-induced hepatotoxicity: clinical and histologic course in two patients. J Clin Oncol. 2012 Sep 20; 30(27):e264-8. PMID: 22802316.
    Citations: 9     Fields:    Translation:Humans
  53. McKay KM, Doyle LA, Lazar AJ, Hornick JL. Expression of ERG, an Ets family transcription factor, distinguishes cutaneous angiosarcoma from histological mimics. Histopathology. 2012 Nov; 61(5):989-91. PMID: 22716285.
    Citations: 5     Fields:    Translation:Humans
  54. Doyle LA, Fletcher CD. EMA positivity in epithelioid fibrous histiocytoma: a potential diagnostic pitfall. J Cutan Pathol. 2011 Sep; 38(9):697-703. PMID: 21752057.
    Citations: 9     Fields:    Translation:Humans
  55. Doyle LA, Odze RD. Eosinophilic esophagitis without abundant eosinophils? The expanding spectrum of a disease that is difficult to define. Dig Dis Sci. 2011 Jul; 56(7):1923-5. PMID: 21533612.
    Citations: 3     Fields:    Translation:HumansCells
  56. Doyle LA, Möller E, Dal Cin P, Fletcher CD, Mertens F, Hornick JL. MUC4 is a highly sensitive and specific marker for low-grade fibromyxoid sarcoma. Am J Surg Pathol. 2011 May; 35(5):733-41. PMID: 21415703.
    Citations: 37     Fields:    Translation:HumansCells
  57. Doyle LA, Sperling LC, Baksh S, Lackey J, Thomas B, Vleugels RA, Qureshi AA, Velazquez EF. Psoriatic alopecia/alopecia areata-like reactions secondary to anti-tumor necrosis factor-a therapy: a novel cause of noncicatricial alopecia. Am J Dermatopathol. 2011 Apr; 33(2):161-6. PMID: 21317611.
    Citations: 8     Fields:    Translation:Humans
  58. Volpicelli ER, Doyle L, Annes JP, Murray MF, Jacobsen E, Murphy GF, Saavedra AP. Erdheim-Chester disease presenting with cutaneous involvement: a case report and literature review. J Cutan Pathol. 2011 Mar; 38(3):280-5. PMID: 21143617.
    Citations: 9     Fields:    Translation:Humans
  59. Buckley O, Doyle L, Padera R, Lakdawala N, Dorbala S, Di Carli M, Kwong R, Desai A, Blankstein R. Cardiomyopathy of uncertain etiology: Complementary role of multimodality imaging with cardiac MRI and 18FDG PET. J Nucl Cardiol. 2010 Apr; 17(2):328-32. PMID: 19777320.
    Citations: 3     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.