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Tilo Winkler, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL141900 (WINKLER, TILO) May 1, 2018 - Apr 30, 2022
    PET fibrin imaging of DVT and PE
    Role: Principal Investigator
  2. R01HL087281 (WINKLER, TILO) Jul 1, 2009 - Nov 30, 2015
    A complex systems approach to bronchoconstriction in Asthma
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kuo YW, Harris RS, Hess DR, Dieffenbach PB, Choi AMK, Fredenburgh LE, Winkler T. Endogenous Carbon Monoxide Production and Diffusing Capacity of the Lung for Carbon Monoxide in Sepsis-Induced Acute Respiratory Distress Syndrome. Crit Care Explor. 2020 Dec; 2(12):e0286. PMID: 33283194.
  2. Zeng C, Motta-Ribeiro GC, Hinoshita T, Lessa MA, Winkler T, Grogg K, Kingston NM, Hutchinson JN, Sholl LM, Fang X, Varelas X, Layne MD, Baron RM, Vidal Melo MF. Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep. Anesthesiology. 2020 11 01; 133(5):1060-1076. PMID: 32796202.
    Citations:    Fields:    Translation:AnimalsCells
  3. Motta-Ribeiro GC, Winkler T. Breathing freely during nitrogen washout. J Appl Physiol (1985). 2020 11 01; 129(5):1150-1151. PMID: 33090907.
    Citations:    Fields:    Translation:Humans
  4. Beda A, Winkler T, Wellman TJ, De Prost N, Tucci M, Vidal Melo MF. Physiological mechanism and spatial distribution of increased alveolar dead-space in early ARDS: An experimental study. Acta Anaesthesiol Scand. 2021 01; 65(1):100-108. PMID: 32931610.
    Citations:    Fields:    
  5. Chen DL, Ballout S, Chen L, Cheriyan J, Choudhury G, Denis-Bacelar AM, Emond E, Erlandsson K, Fisk M, Fraioli F, Groves AM, Gunn RN, Hatazawa J, Holman BF, Hutton BF, Iida H, Lee S, MacNee W, Matsunaga K, Mohan D, Parr D, Rashidnasab A, Rizzo G, Subramanian D, Tal-Singer R, Thielemans K, Tregay N, van Beek EJR, Vass L, Vidal Melo MF, Wellen JW, Wilkinson I, Wilson FJ, Winkler T. Consensus Recommendations on the Use of 18F-FDG PET/CT in Lung Disease. J Nucl Med. 2020 12; 61(12):1701-1707. PMID: 32948678.
    Citations: 1     Fields:    Translation:Humans
  6. Maley JH, Winkler T, Hardin CC. Heterogeneity of Acute Respiratory Distress Syndrome in COVID-19: "Typical" or Not? Am J Respir Crit Care Med. 2020 08 15; 202(4):618-619. PMID: 32579019.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  7. Kohli P, Kelly VJ, Hibbert KA, Corleis B, Kone M, Cho JL, DeFaria-Yeh D, Kwon DS, Medoff BD, Harris RS, Winkler T. PET Imaging Reveals Early Pulmonary Perfusion Abnormalities in HIV Infection Similar to Smoking. J Nucl Med. 2021 Mar; 62(3):405-411. PMID: 32764123.
    Citations:    Fields:    
  8. Hinoshita T, Ribeiro GM, Winkler T, de Prost N, Tucci MR, Costa ELV, Wellman TJ, Hashimoto S, Zeng C, Carvalho AR, Melo MFV. Inflammatory Activity in Atelectatic and Normally Aerated Regions During Early Acute Lung Injury. Acad Radiol. 2020 12; 27(12):1679-1690. PMID: 32173290.
    Citations:    Fields:    Translation:Animals
  9. Rahaghi FN, Winkler T, Kohli P, Nardelli P, Martí-Fuster B, Ross JC, Radhakrishnan R, Blackwater T, Ash SY, de La Bruere I, Diaz AA, Channick RN, Harris RS, Washko GR, San José Estépar R. Quantification of the Pulmonary Vascular Response to Inhaled Nitric Oxide Using Noncontrast Computed Tomography Imaging. Circ Cardiovasc Imaging. 2019 12; 12(1):e008338. PMID: 30632391.
    Citations: 4     Fields:    Translation:Humans
  10. Winkler T. A puzzling question: how can different phenotypes possibly have indistinguishable disease symptoms?. In JP Sturmberg (Ed.), Embracing Complexity in Health: The Transformation of Science, Practice, and Policy. Cham: Springer Nature Switzerland AG. 2019; 59-67. View Publication.
  11. Kohli P, Kelly VJ, Kehl EG, Rodriguez-Lopez J, Hibbert KA, Kone M, Systrom DM, Waxman AB, Venegas JG, Channick R, Winkler T, Harris RS. Perfusion Imaging Distinguishes Exercise Pulmonary Arterial Hypertension at Rest. Am J Respir Crit Care Med. 2019 06 01; 199(11):1438-1441. PMID: 30811948.
    Citations: 1     Fields:    Translation:Humans
  12. Winkler T. Airway transmural pressures in an airway tree during bronchoconstriction in asthma. ASME J of Medical Diagnostics. 2019; 2(1):011005-011005-6. View Publication.
  13. Winkler T. Airway Transmural Pressures in an Airway Tree During Bronchoconstriction in Asthma. J Eng Sci Med Diagn Ther. 2019 Feb; 2(1):0110051-110056. PMID: 32328574.
  14. Osorio-Valencia JS, Wongviriyawong C, Winkler T, Kelly VJ, Harris RS, Venegas JG. Elevation in lung volume and preventing catastrophic airway closure in asthmatics during bronchoconstriction. PLoS One. 2018; 13(12):e0208337. PMID: 30566496.
    Citations: 1     Fields:    Translation:Humans
  15. Fredenburgh LE, Perrella MA, Barragan-Bradford D, Hess DR, Peters E, Welty-Wolf KE, Kraft BD, Harris RS, Maurer R, Nakahira K, Oromendia C, Davies JD, Higuera A, Schiffer KT, Englert JA, Dieffenbach PB, Berlin DA, Lagambina S, Bouthot M, Sullivan AI, Nuccio PF, Kone MT, Malik MJ, Porras MAP, Finkelsztein E, Winkler T, Hurwitz S, Serhan CN, Piantadosi CA, Baron RM, Thompson BT, Choi AM. A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS. JCI Insight. 2018 12 06; 3(23). PMID: 30518685.
    Citations: 13     Fields:    Translation:HumansCTClinical Trials
  16. Motta-Ribeiro GC, Hashimoto S, Winkler T, Baron RM, Grogg K, Paula LFSC, Santos A, Zeng C, Hibbert K, Harris RS, Bajwa E, Vidal Melo MF. Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury. Am J Respir Crit Care Med. 2018 10 01; 198(7):891-902. PMID: 29787304.
    Citations: 13     Fields:    Translation:HumansAnimals
  17. Motta-Ribeiro G, Winkler T, Hashimoto S, Vidal Melo MF. Spatial Heterogeneity of Lung Strain and Aeration and Regional Inflammation During Early Lung Injury Assessed with PET/CT. Acad Radiol. 2019 03; 26(3):313-325. PMID: 30057194.
    Citations:    Fields:    Translation:Animals
  18. Kelly VJ, Winkler T, Harris RS. Reply to Dorrington et al. and to Swenson: "Hypercapnic Pulmonary Vasoconstriction Contributes to Regional Perfusion Distribution: Relevance to Asthma" and "Hypercapnic Pulmonary Vasoconstriction as a Mechanism for Regional Perfusion Redistribution in Asthma". Am J Respir Crit Care Med. 2018 03 01; 197(5):684. PMID: 29072850.
    Citations:    Fields:    Translation:Humans
  19. Kelly VJ, Hibbert KA, Kohli P, Kone M, Greenblatt EE, Venegas JG, Winkler T, Harris RS. Hypoxic Pulmonary Vasoconstriction Does Not Explain All Regional Perfusion Redistribution in Asthma. Am J Respir Crit Care Med. 2017 10 01; 196(7):834-844. PMID: 28644040.
    Citations: 5     Fields:    Translation:Humans
  20. Güldner A, Braune A, Ball L, Leme Silva P, Samary C, Insorsi A, Huhle R, Rentzsch I, Becker C, Oehme L, Andreeff M, Vidal Melo MF, Winkler T, Pelosi P, Rieken Macedo Rocco P, Kotzerke J, Gama de Abreu M. The authors reply. Crit Care Med. 2017 03; 45(3):e328-e329. PMID: 28212230.
    Citations: 2     Fields:    
  21. Wellman TJ, de Prost N, Tucci M, Winkler T, Baron RM, Filipczak P, Raby B, Chu JH, Harris RS, Musch G, Dos Reis Falcao LF, Capelozzi V, Venegas JG, Vidal Melo MF. Lung Metabolic Activation as an Early Biomarker of Acute Respiratory Distress Syndrome and Local Gene Expression Heterogeneity. Anesthesiology. 2016 11; 125(5):992-1004. PMID: 27611185.
    Citations: 4     Fields:    Translation:Animals
  22. Güldner A, Braune A, Ball L, Silva PL, Samary C, Insorsi A, Huhle R, Rentzsch I, Becker C, Oehme L, Andreeff M, Vidal Melo MF, Winkler T, Pelosi P, Rocco PR, Kotzerke J, Gama de Abreu M. Comparative Effects of Volutrauma and Atelectrauma on Lung Inflammation in Experimental Acute Respiratory Distress Syndrome. Crit Care Med. 2016 09; 44(9):e854-65. PMID: 27035236.
    Citations: 24     Fields:    Translation:Animals
  23. Paula LF, Wellman TJ, Winkler T, Spieth PM, Güldner A, Venegas JG, Gama de Abreu M, Carvalho AR, Vidal Melo MF. Regional tidal lung strain in mechanically ventilated normal lungs. J Appl Physiol (1985). 2016 12 01; 121(6):1335-1347. PMID: 27445302.
    Citations: 6     Fields:    Translation:Animals
  24. Greenblatt EE, Winkler T, Harris RS, Kelly VJ, Kone M, Katz I, Martin A, Caillibotte G, Hess DR, Venegas JG. Regional Ventilation and Aerosol Deposition with Helium-Oxygen in Bronchoconstricted Asthmatic Lungs. J Aerosol Med Pulm Drug Deliv. 2016 06; 29(3):260-72. PMID: 26824777.
    Citations: 4     Fields:    Translation:Humans
  25. Kelly VJ, Winkler T, Venegas JG, Kone M, Hamilos DL, Afshar R, Cho JL, Luster AD, Medoff BD, Harris RS. Allergic Non-Asthmatic Adults Have Regional Pulmonary Responses to Segmental Allergen Challenge. PLoS One. 2015; 10(12):e0143976. PMID: 26640951.
    Citations: 1     Fields:    Translation:Humans
  26. Johansen T, Winkler T, Kelly VJ, Osorio-Valencia JS, Greenblatt EE, Harris RS, Venegas JG. A method for mapping regional oxygen and CO2 transfer in the lung. Respir Physiol Neurobiol. 2016 Feb 01; 222:29-47. PMID: 26563454.
    Citations: 3     Fields:    Translation:Humans
  27. Fredenburgh LE, Kraft BD, Hess DR, Harris RS, Wolf MA, Suliman HB, Roggli VL, Davies JD, Winkler T, Stenzler A, Baron RM, Thompson BT, Choi AM, Welty-Wolf KE, Piantadosi CA. Effects of inhaled CO administration on acute lung injury in baboons with pneumococcal pneumonia. . 2015 Oct 15; 309(8):L834-46. PMID: 26320156.
    Citations: 11     Translation:HumansAnimals
  28. Greenblatt EE, Winkler T, Harris RS, Kelly VJ, Kone M, Katz I, Martin AR, Caillibotte G, Venegas J. What Causes Uneven Aerosol Deposition in the Bronchoconstricted Lung? A Quantitative Imaging Study. J Aerosol Med Pulm Drug Deliv. 2016 Feb; 29(1):57-75. PMID: 25977979.
    Citations: 9     Fields:    
  29. Wellman TJ, Winkler T, Vidal Melo MF. Modeling of Tracer Transport Delays for Improved Quantification of Regional Pulmonary ¹8F-FDG Kinetics, Vascular Transit Times, and Perfusion. Ann Biomed Eng. 2015 Nov; 43(11):2722-34. PMID: 25940652.
    Citations: 1     Fields:    Translation:Animals
  30. Winkler T, Melo MF, Degani-Costa LH, Harris RS, Correia JA, Musch G, Venegas JG. Estimation of noise-free variance to measure heterogeneity. PLoS One. 2015; 10(4):e0123417. PMID: 25906374.
    Citations:    Fields:    Translation:Humans
  31. Golnabi AH, Harris RS, Venegas JG, Winkler T. Deep inspiration and the emergence of ventilation defects during bronchoconstriction: a computational study. PLoS One. 2014; 9(11):e112443. PMID: 25402457.
    Citations: 3     Fields:    Translation:Humans
  32. de Prost N, Feng Y, Wellman T, Tucci MR, Costa EL, Musch G, Winkler T, Harris RS, Venegas JG, Chao W, Vidal Melo MF. 18F-FDG kinetics parameters depend on the mechanism of injury in early experimental acute respiratory distress syndrome. J Nucl Med. 2014 Nov; 55(11):1871-7. PMID: 25286924.
    Citations: 15     Fields:    Translation:AnimalsCells
  33. Greenblatt EE, Butler JP, Venegas JG, Winkler T. Pendelluft in the bronchial tree. J Appl Physiol (1985). 2014 Nov 01; 117(9):979-88. PMID: 25170072.
    Citations: 12     Fields:    Translation:Humans
  34. Greenblatt EE, Winkler T, Harris RS, Kelly VJ, Kone M, Venegas J. Analysis of three-dimensional aerosol deposition in pharmacologically relevant terms: beyond black or white ROIs. J Aerosol Med Pulm Drug Deliv. 2015 Apr; 28(2):116-29. PMID: 25050754.
    Citations: 5     Fields:    Translation:Humans
  35. Wellman TJ, Winkler T, Costa EL, Musch G, Harris RS, Zheng H, Venegas JG, Vidal Melo MF. Effect of local tidal lung strain on inflammation in normal and lipopolysaccharide-exposed sheep*. Crit Care Med. 2014 Jul; 42(7):e491-500. PMID: 24758890.
    Citations: 31     Fields:    Translation:Animals
  36. Winkler T, Venegas JG, Harris RS. MATHEMATICAL MODELING OF VENTILATION DEFECTS IN ASTHMA. Drug Discov Today Dis Models. 2015; 15:3-8. PMID: 26744595.
    Citations: 2     
  37. Musch G, Winkler T, Harris RS, Vidal Melo MF, Wellman TJ, de Prost N, Kradin RL, Venegas JG. Lung [(18)F]fluorodeoxyglucose uptake and ventilation-perfusion mismatch in the early stage of experimental acute smoke inhalation. Anesthesiology. 2014 Mar; 120(3):683-93. PMID: 24051392.
    Citations: 4     Fields:    Translation:Animals
  38. de Prost N, Costa EL, Wellman T, Musch G, Tucci MR, Winkler T, Harris R, Venegas JG, Kavanagh BP, Vidal Melo MF. Effects of ventilation strategy on distribution of lung inflammatory cell activity. Crit Care. 2013 Aug 15; 17(4):R175. PMID: 23947920.
    Citations: 17     Fields:    Translation:AnimalsCells
  39. Kelmenson DA, Kelly VJ, Winkler T, Kone MT, Musch G, Melo MF, Venegas JG, Harris RS. The effect of omalizumab on ventilation and perfusion in adults with allergic asthma. Am J Nucl Med Mol Imaging. 2013; 3(4):350-60. PMID: 23901360.
  40. Tucci MR, Costa EL, Wellman TJ, Musch G, Winkler T, Harris RS, Venegas JG, Amato MB, Melo MF. Regional lung derecruitment and inflammation during 16 hours of mechanical ventilation in supine healthy sheep. Anesthesiology. 2013 Jul; 119(1):156-65. PMID: 23535501.
    Citations: 6     Fields:    Translation:AnimalsCells
  41. Saha D, Takahashi K, de Prost N, Winkler T, Pinilla-Vera M, Baron RM, Vidal Melo MF. Micro-autoradiographic assessment of cell types contributing to 2-deoxy-2-[(18)F]fluoro-D-glucose uptake during ventilator-induced and endotoxemic lung injury. Mol Imaging Biol. 2013 Feb; 15(1):19-27. PMID: 22752654.
    Citations: 18     Fields:    Translation:AnimalsCells
  42. Harris RS, Fujii-Rios H, Winkler T, Musch G, Vidal Melo MF, Venegas JG. Ventilation defect formation in healthy and asthma subjects is determined by lung inflation. PLoS One. 2012; 7(12):e53216. PMID: 23285270.
    Citations: 11     Fields:    Translation:Humans
  43. Dittrich AS, Winkler T, Wellman T, de Prost N, Musch G, Harris RS, Vidal Melo MF. Modeling 18F-FDG kinetics during acute lung injury: experimental data and estimation errors. PLoS One. 2012; 7(10):e47588. PMID: 23118881.
    Citations: 9     Fields:    Translation:HumansAnimals
  44. Venegas J, Winkler T, Harris RS. Lung physiology and aerosol deposition imaged with positron emission tomography. J Aerosol Med Pulm Drug Deliv. 2013 Feb; 26(1):1-8. PMID: 22856557.
    Citations: 5     Fields:    Translation:HumansAnimals
  45. Wellman TJ, Winkler T, Costa EL, Musch G, Harris RS, Venegas JG, Vidal Melo MF. Effect of regional lung inflation on ventilation heterogeneity at different length scales during mechanical ventilation of normal sheep lungs. J Appl Physiol (1985). 2012 Sep; 113(6):947-57. PMID: 22678958.
    Citations: 18     Fields:    Translation:Animals
  46. Winkler T, Venegas JG. Are all airways equal? J Appl Physiol (1985). 2012 May; 112(9):1431-2. PMID: 22383504.
    Citations: 3     Fields:    Translation:Animals
  47. Harris RS, Venegas JG, Wongviriyawong C, Winkler T, Kone M, Musch G, Vidal Melo MF, de Prost N, Hamilos DL, Afshar R, Cho J, Luster AD, Medoff BD. 18F-FDG uptake rate is a biomarker of eosinophilic inflammation and airway response in asthma. J Nucl Med. 2011 Nov; 52(11):1713-20. PMID: 21990575.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  48. de Prost N, Costa EL, Wellman T, Musch G, Winkler T, Tucci MR, Harris RS, Venegas JG, Vidal Melo MF. Effects of surfactant depletion on regional pulmonary metabolic activity during mechanical ventilation. J Appl Physiol (1985). 2011 Nov; 111(5):1249-58. PMID: 21799132.
    Citations: 17     Fields:    Translation:Animals
  49. Winkler T, Venegas JG. Self-organized patterns of airway narrowing. J Appl Physiol (1985). 2011 May; 110(5):1482-6. PMID: 21252219.
    Citations: 11     Fields:    Translation:HumansAnimals
  50. Winkler T, Suki B. Emergent structure-function relations in emphysema and asthma. Crit Rev Biomed Eng. 2011; 39(4):263-80. PMID: 22011233.
    Citations: 17     Fields:    Translation:Humans
  51. Wongviriyawong C, Winkler T, Harris RS, Venegas JG. Dynamics of tidal volume and ventilation heterogeneity under pressure-controlled ventilation during bronchoconstriction: a simulation study. J Appl Physiol (1985). 2010 Oct; 109(4):1211-8. PMID: 20671035.
    Citations: 3     Fields:    Translation:Humans
  52. Wellman TJ, Winkler T, Costa EL, Musch G, Harris RS, Venegas JG, Melo MF. Measurement of regional specific lung volume change using respiratory-gated PET of inhaled 13N-nitrogen. J Nucl Med. 2010 Apr; 51(4):646-53. PMID: 20237036.
    Citations: 16     Fields:    Translation:Animals
  53. Costa EL, Musch G, Winkler T, Schroeder T, Harris RS, Jones HA, Venegas JG, Vidal Melo MF. Mild endotoxemia during mechanical ventilation produces spatially heterogeneous pulmonary neutrophilic inflammation in sheep. Anesthesiology. 2010 Mar; 112(3):658-69. PMID: 20179503.
    Citations: 30     Fields:    Translation:AnimalsCells
  54. Vidal Melo MF, Winkler T, Harris RS, Musch G, Greene RE, Venegas JG. Spatial heterogeneity of lung perfusion assessed with (13)N PET as a vascular biomarker in chronic obstructive pulmonary disease. J Nucl Med. 2010 Jan; 51(1):57-65. PMID: 20008987.
    Citations: 23     Fields:    Translation:Humans
  55. Harris RS, Winkler T, Musch G, Vidal Melo MF, Schroeder T, Tgavalekos N, Venegas JG. The prone position results in smaller ventilation defects during bronchoconstriction in asthma. J Appl Physiol (1985). 2009 Jul; 107(1):266-74. PMID: 19443742.
    Citations: 12     Fields:    Translation:Humans
  56. Schroeder T, Vidal Melo MF, Musch G, Harris RS, Venegas JG, Winkler T. Modeling pulmonary kinetics of 2-deoxy-2-[18F]fluoro-D-glucose during acute lung injury. Acad Radiol. 2008 Jun; 15(6):763-75. PMID: 18486012.
    Citations: 29     Fields:    Translation:Animals
  57. Schroeder T, Vidal Melo MF, Musch G, Harris RS, Venegas JG, Winkler T. Image-derived input function for assessment of 18F-FDG uptake by the inflamed lung. J Nucl Med. 2007 Nov; 48(11):1889-96. PMID: 17942803.
    Citations: 19     Fields:    Translation:HumansAnimals
  58. Musch G, Bellani G, Vidal Melo MF, Harris RS, Winkler T, Schroeder T, Venegas JG. Relation between shunt, aeration, and perfusion in experimental acute lung injury. Am J Respir Crit Care Med. 2008 Feb 01; 177(3):292-300. PMID: 17932380.
    Citations: 17     Fields:    Translation:Animals
  59. Winkler T. In silico modeling of airway mechanics. Drug discovery today: disease models. 2007; 4(3):125-129. View Publication.
  60. Winkler T, Venegas JG. Complex airway behavior and paradoxical responses to bronchoprovocation. J Appl Physiol (1985). 2007 Aug; 103(2):655-63. PMID: 17478609.
    Citations: 33     Fields:    Translation:Humans
  61. Musch G, Venegas JG, Bellani G, Winkler T, Schroeder T, Petersen B, Harris RS, Melo MF. Regional gas exchange and cellular metabolic activity in ventilator-induced lung injury. Anesthesiology. 2007 Apr; 106(4):723-35. PMID: 17413910.
    Citations: 41     Fields:    Translation:Animals
  62. Tgavalekos NT, Musch G, Harris RS, Vidal Melo MF, Winkler T, Schroeder T, Callahan R, Lutchen KR, Venegas JG. Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmatics. Eur Respir J. 2007 Jun; 29(6):1174-81. PMID: 17360726.
    Citations: 25     Fields:    Translation:Humans
  63. Schroeder T, Vidal Melo MF, Musch G, Harris RS, Winkler T, Venegas JG. PET imaging of regional 18F-FDG uptake and lung function after cigarette smoke inhalation. J Nucl Med. 2007 Mar; 48(3):413-9. PMID: 17332619.
    Citations: 16     Fields:    Translation:AnimalsPHPublic Health
  64. Harris RS, Winkler T, Tgavalekos N, Musch G, Melo MF, Schroeder T, Chang Y, Venegas JG. Regional pulmonary perfusion, inflation, and ventilation defects in bronchoconstricted patients with asthma. Am J Respir Crit Care Med. 2006 Aug 01; 174(3):245-53. PMID: 16690973.
    Citations: 39     Fields:    Translation:Humans
  65. Venegas JG, Schroeder T, Harris S, Harris S, Winkler RT, Melo MF. The distribution of ventilation during bronchoconstriction is patchy and bimodal: a PET imaging study. Respir Physiol Neurobiol. 2005 Aug 25; 148(1-2):57-64. PMID: 15994134.
    Citations: 34     Fields:    Translation:Animals
  66. Richter T, Bellani G, Scott Harris R, Vidal Melo MF, Winkler T, Venegas JG, Musch G. Effect of prone position on regional shunt, aeration, and perfusion in experimental acute lung injury. Am J Respir Crit Care Med. 2005 Aug 15; 172(4):480-7. PMID: 15901611.
    Citations: 46     Fields:    Translation:Animals
  67. Venegas JG, Winkler T, Musch G, Vidal Melo MF, Layfield D, Tgavalekos N, Fischman AJ, Callahan RJ, Bellani G, Harris RS. Self-organized patchiness in asthma as a prelude to catastrophic shifts. Nature. 2005 Apr 07; 434(7034):777-82. PMID: 15772676.
    Citations: 146     Fields:    Translation:Humans
  68. Musch G, Harris RS, Vidal Melo MF, O'Neill KR, Layfield JD, Winkler T, Venegas JG. Mechanism by which a sustained inflation can worsen oxygenation in acute lung injury. Anesthesiology. 2004 Feb; 100(2):323-30. PMID: 14739807.
    Citations: 29     Fields:    Translation:Animals
  69. Vidal Melo MF, Layfield D, Harris RS, O'Neill K, Musch G, Richter T, Winkler T, Fischman AJ, Venegas JG. Quantification of regional ventilation-perfusion ratios with PET. J Nucl Med. 2003 Dec; 44(12):1982-91. PMID: 14660725.
    Citations: 45     Fields:    Translation:Animals
  70. O'Neill K, Venegas JG, Richter T, Harris RS, Layfield JD, Musch G, Winkler T, Melo MF. Modeling kinetics of infused 13NN-saline in acute lung injury. J Appl Physiol (1985). 2003 Dec; 95(6):2471-84. PMID: 12897030.
    Citations: 15     Fields:    Translation:Animals
  71. Gama de Abreu M, Winkler T, Pahlitzsch T, Weismann D, Albrecht DM. Performance of the partial CO2 rebreathing technique under different hemodynamic and ventilation/perfusion matching conditions. Crit Care Med. 2003 Feb; 31(2):543-51. PMID: 12576964.
    Citations: 7     Fields:    Translation:HumansAnimals
  72. Musch G, Layfield JD, Harris RS, Melo MF, Winkler T, Callahan RJ, Fischman AJ, Venegas JG. Topographical distribution of pulmonary perfusion and ventilation, assessed by PET in supine and prone humans. J Appl Physiol (1985). 2002 Nov; 93(5):1841-51. PMID: 12381773.
    Citations: 60     Fields:    Translation:Humans
  73. de Abreu MG, Geiger S, Winkler T, Ragaller M, Pfeiffer T, Leutheuser D, Albrecht DM. Evaluation of a new device for noninvasive measurement of nonshunted pulmonary capillary blood flow in patients with acute lung injury. Intensive Care Med. 2002 Mar; 28(3):318-23. PMID: 11904662.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  74. Ragaller M, Bleyl J, Tschö U, Winkler T, Regner M, Rasche S, Koch T, Albrecht M. Effects of inhalation of perfluorocarbon aerosol on oxygenation and pulmonary function compared to PGI2 inhalation in a sheep model of oleic acid-induced lung injury. Intensive Care Med. 2001 May; 27(5):889-97. PMID: 11430546.
    Citations: 5     Fields:    Translation:Animals
  75. Winkler T. Identifikation einer vereinigten Modells für Ventilationsmechanik und Gasaustausch bei maschineller Beatmung. Wagner D, et al. (Eds.) Ausgezeichnete Dissertationen 2000, Lecture Notes in Informatics - Dissertations. 2001; D-1:165-174.
  76. Winkler T. Ventilationsmechanik und Gasaustausch: Identifikation eines vereinigten Modells bei maschineller Beatmung. 2000.
  77. Winkler T. Identifikation eines vereinigten Modells für Ventilationsmechanik und Gasaustausch bei maschineller Beatmung [Ph.D.]. 2000.
  78. Winkler T, Krause A, Kaiser S. Simulation of mechanical respiration using a multicompartment model for ventilation mechanics and gas exchange. Int J Clin Monit Comput. 1995; 12(4):231-9. PMID: 8820330.
    Citations: 4     Fields:    Translation:Humans
  79. Winkler T. Entwurf und Realisierung eines mathematischen Mehrkompartimentmodells zur Beschreibung der Lungenmechanik, Gasaustausch und Metabolismus intubierter Patienten [diploma]. 1992.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.