Harvard Catalyst Profiles

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Dipak Panigrahy, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA170549 (PANIGRAHY, DIPAK) Sep 18, 2012 - Jul 31, 2016
    Controlling cancer with aspirin-triggered stimulation of resolution
    Role: Principal Investigator
  2. R01CA148633 (PANIGRAHY, DIPAK) Aug 1, 2010 - May 31, 2015
    Control of cancer and metastasis by endothelial-derived epoxyeicosatrienoic acids
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gilligan MM, Gartung A, Sulciner ML, Norris PC, Sukhatme VP, Bielenberg DR, Huang S, Kieran MW, Serhan CN, Panigrahy D. Aspirin-triggered proresolving mediators stimulate resolution in cancer. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6292-6297. PMID: 30862734.
  2. Gartung A, Yang J, Sukhatme VP, Bielenberg DR, Fernandes D, Chang J, Schmidt BA, Hwang SH, Zurakowski D, Huang S, Kieran MW, Hammock BD, Panigrahy D. Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor. Proc Natl Acad Sci U S A. 2019 01 29; 116(5):1698-1703. PMID: 30647111.
    Citations:    Fields:    
  3. Gartung A, Panigrahy D. Preface. Cancer Metastasis Rev. 2018 09; 37(2-3):201-202. PMID: 30117006.
  4. Sulciner ML, Gartung A, Gilligan MM, Serhan CN, Panigrahy D. Targeting lipid mediators in cancer biology. Cancer Metastasis Rev. 2018 09; 37(2-3):557-572. PMID: 30136088.
  5. Chang J, Bhasin SS, Bielenberg DR, Sukhatme VP, Bhasin M, Huang S, Kieran MW, Panigrahy D. Chemotherapy-generated cell debris stimulates colon carcinoma tumor growth via osteopontin. FASEB J. 2019 Jan; 33(1):114-125. PMID: 29957058.
    Citations:    Fields:    
  6. Serhan K, Gartung A, Panigrahy D. Drawing a link between the thromboxane A2 pathway and the role of platelets and tumor cells in ovarian cancer. Prostaglandins Other Lipid Mediat. 2018 07; 137:40-45. PMID: 29933028.
    Citations:    Fields:    Translation:HumansAnimalsCells
  7. Yang H, Wang W, Romano KA, Gu M, Sanidad KZ, Kim D, Yang J, Schmidt B, Panigrahy D, Pei R, Martin DA, Ozay EI, Wang Y, Song M, Bolling BW, Xiao H, Minter LM, Yang GY, Liu Z, Rey FE, Zhang G. A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice. Sci Transl Med. 2018 May 30; 10(443). PMID: 29848663.
    Citations:    Fields:    
  8. Panigrahy D, Sahu PK. P and T wave detection and delineation of ECG signal using differential evolution (DE) optimization strategy. Australas Phys Eng Sci Med. 2018 Mar; 41(1):225-241. PMID: 29484531.
    Citations:    Fields:    Translation:Humans
  9. Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR, Schmidt B, Dalli J, Greene ER, Gus-Brautbar Y, Piwowarski J, Mammoto T, Zurakowski D, Perretti M, Sukhatme VP, Kaipainen A, Kieran MW, Huang S, Panigrahy D. Resolvins suppress tumor growth and enhance cancer therapy. J Exp Med. 2018 01 02; 215(1):115-140. PMID: 29191914.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  10. Panigrahy D, Zeldin DC. WEC 2016 special issue editorial. Prostaglandins Other Lipid Mediat. 2017 09; 132:1-2. PMID: 28928099.
    Citations:    Fields:    Translation:Humans
  11. Rand AA, Barnych B, Morisseau C, Cajka T, Lee KSS, Panigrahy D, Hammock BD. Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids. Proc Natl Acad Sci U S A. 2017 04 25; 114(17):4370-4375. PMID: 28396419.
    Citations: 5     Fields:    Translation:Humans
  12. Lee HY, Parkinson EI, Granchi C, Paterni I, Panigrahy D, Seth P, Minutolo F, Hergenrother PJ. Reactive Oxygen Species Synergize To Potently and Selectively Induce Cancer Cell Death. ACS Chem Biol. 2017 05 19; 12(5):1416-1424. PMID: 28345875.
    Citations:    Fields:    Translation:Animals
  13. Panigrahy D, Sahu PK. Extraction of fetal ECG signal by an improved method using extended Kalman smoother framework from single channel abdominal ECG signal. Australas Phys Eng Sci Med. 2017 Mar; 40(1):191-207. PMID: 28210991.
    Citations: 1     Fields:    Translation:Humans
  14. Wepler M, Beloiartsev A, Buswell MD, Panigrahy D, Malhotra R, Buys ES, Radermacher P, Ichinose F, Bloch DB, Zapol WM. Soluble epoxide hydrolase deficiency or inhibition enhances murine hypoxic pulmonary vasoconstriction after lipopolysaccharide challenge. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 01; 311(6):L1213-L1221. PMID: 27815261.
    Citations: 1     Fields:    
  15. Panigrahy D, Sahu PK. Extended Kalman smoother with differential evolution technique for denoising of ECG signal. Australas Phys Eng Sci Med. 2016 Sep; 39(3):783-95. PMID: 27542170.
    Citations: 1     Fields:    Translation:Humans
  16. Shahrabi-Farahani S, Gallottini M, Martins F, Li E, Mudge DR, Nakayama H, Hida K, Panigrahy D, D'Amore PA, Bielenberg DR. Neuropilin 1 Receptor Is Up-Regulated in Dysplastic Epithelium and Oral Squamous Cell Carcinoma. Am J Pathol. 2016 Apr; 186(4):1055-64. PMID: 26877262.
    Citations: 2     Fields:    Translation:HumansCells
  17. Panigrahy D, Rakshit M, Sahu PK. FPGA Implementation of Heart Rate Monitoring System. J Med Syst. 2016 Mar; 40(3):49. PMID: 26643079.
    Citations: 2     Fields:    Translation:Humans
  18. Li P, Lahvic JL, Binder V, Pugach EK, Riley EB, Tamplin OJ, Panigrahy D, Bowman TV, Barrett FG, Heffner GC, McKinney-Freeman S, Schlaeger TM, Daley GQ, Zeldin DC, Zon LI. Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature. 2015 Jul 23; 523(7561):468-71. PMID: 26201599.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  19. Panigrahy D, Hammock B. Editorial: 15th International Winter Eicosanoid Conference. Prostaglandins Other Lipid Mediat. 2014 Oct; 113-115:1. PMID: 25453874.
    Citations:    Fields:    Translation:HumansAnimals
  20. Panigrahy D, Adini I, Mamluk R, Levonyak N, Bruns CJ, D'Amore PA, Klagsbrun M, Bielenberg DR. Regulation of soluble neuropilin 1, an endogenous angiogenesis inhibitor, in liver development and regeneration. Pathology. 2014 Aug; 46(5):416-23. PMID: 24977735.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  21. Zhang G, Panigrahy D, Hwang SH, Yang J, Mahakian LM, Wettersten HI, Liu JY, Wang Y, Ingham ES, Tam S, Kieran MW, Weiss RH, Ferrara KW, Hammock BD. Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proc Natl Acad Sci U S A. 2014 Jul 29; 111(30):11127-32. PMID: 25024195.
    Citations: 24     Fields:    Translation:Animals
  22. Wang W, Zhu J, Lyu F, Panigrahy D, Ferrara KW, Hammock B, Zhang G. ?-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer. Prostaglandins Other Lipid Mediat. 2014 Oct; 113-115:13-20. PMID: 25019221.
    Citations: 21     Fields:    Translation:HumansAnimals
  23. Gus-Brautbar Y, Panigrahy D. Time heals all wounds--but 12-HHT is faster. J Exp Med. 2014 Jun 02; 211(6):1008. PMID: 24890114.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  24. Dahlman JE, Barnes C, Khan O, Thiriot A, Jhunjunwala S, Shaw TE, Xing Y, Sager HB, Sahay G, Speciner L, Bader A, Bogorad RL, Yin H, Racie T, Dong Y, Jiang S, Seedorf D, Dave A, Sandu KS, Webber MJ, Novobrantseva T, Ruda VM, Lytton-Jean AKR, Levins CG, Kalish B, Mudge DK, Perez M, Abezgauz L, Dutta P, Smith L, Charisse K, Kieran MW, Fitzgerald K, Nahrendorf M, Danino D, Tuder RM, von Andrian UH, Akinc A, Schroeder A, Panigrahy D, Kotelianski V, Langer R, Anderson DG. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nat Nanotechnol. 2014 Aug; 9(8):648-655. PMID: 24813696.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  25. Shao Z, Fu Z, Stahl A, Joyal JS, Hatton C, Juan A, Hurst C, Evans L, Cui Z, Pei D, Gong Y, Xu D, Tian K, Bogardus H, Edin ML, Lih F, Sapieha P, Chen J, Panigrahy D, Hellstrom A, Zeldin DC, Smith LE. Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):581-6. PMID: 24458713.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  26. Mammoto T, Jiang A, Jiang E, Panigrahy D, Kieran MW, Mammoto A. Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression. Am J Pathol. 2013 Oct; 183(4):1293-1305. PMID: 23928381.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  27. Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, Edin ML, Lee CR, Benny O, Mudge DK, Butterfield CE, Mammoto A, Mammoto T, Inceoglu B, Jenkins RL, Simpson MA, Akino T, Lih FB, Tomer KB, Ingber DE, Hammock BD, Falck JR, Manthati VL, Kaipainen A, D'Amore PA, Puder M, Zeldin DC, Kieran MW. Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13528-33. PMID: 23898174.
    Citations: 40     Fields:    Translation:AnimalsCells
  28. Kalish BT, Kieran MW, Puder M, Panigrahy D. The growing role of eicosanoids in tissue regeneration, repair, and wound healing. Prostaglandins Other Lipid Mediat. 2013 Jul-Aug; 104-105:130-8. PMID: 23727457.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  29. Dearling JL, Barnes JW, Panigrahy D, Zimmerman RE, Fahey F, Treves ST, Morrison MS, Kieran MW, Packard AB. Specific uptake of 99mTc-NC100692, an avß3-targeted imaging probe, in subcutaneous and orthotopic tumors. Nucl Med Biol. 2013 Aug; 40(6):788-94. PMID: 23701702.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  30. Zhang G, Panigrahy D, Mahakian LM, Yang J, Liu JY, Stephen Lee KS, Wettersten HI, Ulu A, Hu X, Tam S, Hwang SH, Ingham ES, Kieran MW, Weiss RH, Ferrara KW, Hammock BD. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6530-5. PMID: 23553837.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  31. Stahl A, Joyal JS, Chen J, Sapieha P, Juan AM, Hatton CJ, Pei DT, Hurst CG, Seaward MR, Krah NM, Dennison RJ, Greene ER, Boscolo E, Panigrahy D, Smith LE. SOCS3 is an endogenous inhibitor of pathologic angiogenesis. Blood. 2012 Oct 04; 120(14):2925-9. PMID: 22791286.
    Citations: 19     Fields:    Translation:AnimalsCells
  32. Barnés CM, Prox D, Christison-Lagay EA, Le HD, Short S, Cassiola F, Panigrahy D, Chaponis D, Butterfield C, Nehra D, Fallon EM, Kieran M, Folkman J, Puder M. Inhibition of neuroblastoma cell proliferation with omega-3 fatty acids and treatment of a murine model of human neuroblastoma using a diet enriched with omega-3 fatty acids in combination with sunitinib. Pediatr Res. 2012 Feb; 71(2):168-78. PMID: 22258128.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  33. Panigrahy D, Edin ML, Lee CR, Huang S, Bielenberg DR, Butterfield CE, Barnés CM, Mammoto A, Mammoto T, Luria A, Benny O, Chaponis DM, Dudley AC, Greene ER, Vergilio JA, Pietramaggiori G, Scherer-Pietramaggiori SS, Short SM, Seth M, Lih FB, Tomer KB, Yang J, Schwendener RA, Hammock BD, Falck JR, Manthati VL, Ingber DE, Kaipainen A, D'Amore PA, Kieran MW, Zeldin DC. Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J Clin Invest. 2012 Jan; 122(1):178-91. PMID: 22182838.
    Citations: 69     Fields:    Translation:HumansAnimals
  34. Panigrahy D, Greene ER, Pozzi A, Wang DW, Zeldin DC. EET signaling in cancer. Cancer Metastasis Rev. 2011 Dec; 30(3-4):525-40. PMID: 22009066.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  35. Greene ER, Huang S, Serhan CN, Panigrahy D. Regulation of inflammation in cancer by eicosanoids. Prostaglandins Other Lipid Mediat. 2011 Nov; 96(1-4):27-36. PMID: 21864702.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  36. Panigrahy D, Kaipainen A, Greene ER, Huang S. Cytochrome P450-derived eicosanoids: the neglected pathway in cancer. Cancer Metastasis Rev. 2010 Dec; 29(4):723-35. PMID: 20941528.
    Citations: 51     Fields:    Translation:HumansAnimals
  37. Fernandez CA, Roy R, Lee S, Yang J, Panigrahy D, Van Vliet KJ, Moses MA. The anti-angiogenic peptide, loop 6, binds insulin-like growth factor-1 receptor. J Biol Chem. 2010 Dec 31; 285(53):41886-95. PMID: 20940305.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  38. Benny O, Nakai K, Yoshimura T, Bazinet L, Akula JD, Nakao S, Hafezi-Moghadam A, Panigrahy D, Pakneshan P, D'Amato RJ. Broad spectrum antiangiogenic treatment for ocular neovascular diseases. PLoS One. 2010 Sep 01; 5(9). PMID: 20824139.
    Citations: 9     Fields:    Translation:HumansAnimals
  39. Panigrahy D, Kaipainen A, Butterfield CE, Chaponis DM, Laforme AM, Folkman J, Kieran MW. Inhibition of tumor angiogenesis by oral etoposide. Exp Ther Med. 2010 Sep; 1(5):739-746. PMID: 22993597.
    Citations: 11     
  40. Robbins ME, Linard C, Panigrahy D. PPARs and Anticancer Therapies. PPAR Res. 2010; 2010:536415. PMID: 20614003.
    Citations: 3     
  41. Panigrahy D, Kaipainen A, Kieran MW, Huang S. PPARs: A Double-Edged Sword in Cancer Therapy? PPAR Res. 2008; 2008:350351. PMID: 19590598.
    Citations: 10     
  42. Fannon M, Forsten-Williams K, Nugent MA, Gregory KJ, Chu CL, Goerges-Wildt AL, Panigrahy D, Kaipainen A, Barnes C, Lapp C, Shing Y. Sucrose octasulfate regulates fibroblast growth factor-2 binding, transport, and activity: potential for regulation of tumor growth. J Cell Physiol. 2008 May; 215(2):434-41. PMID: 18163458.
    Citations: 3     Fields:    Translation:AnimalsCells
  43. Panigrahy D, Kaipainen A, Huang S, Butterfield CE, Barnés CM, Fannon M, Laforme AM, Chaponis DM, Folkman J, Kieran MW. PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition. Proc Natl Acad Sci U S A. 2008 Jan 22; 105(3):985-90. PMID: 18199835.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  44. Kaipainen A, Kieran MW, Huang S, Butterfield C, Bielenberg D, Mostoslavsky G, Mulligan R, Folkman J, Panigrahy D. PPARalpha deficiency in inflammatory cells suppresses tumor growth. PLoS One. 2007 Feb 28; 2(2):e260. PMID: 17327920.
    Citations: 38     Fields:    Translation:AnimalsCells
  45. Panigrahy D, Huang S, Kieran MW, Kaipainen A. PPARgamma as a therapeutic target for tumor angiogenesis and metastasis. Cancer Biol Ther. 2005 Jul; 4(7):687-93. PMID: 16082179.
    Citations: 46     Fields:    Translation:Humans
  46. Hida K, Hida Y, Amin DN, Flint AF, Panigrahy D, Morton CC, Klagsbrun M. Tumor-associated endothelial cells with cytogenetic abnormalities. Cancer Res. 2004 Nov 15; 64(22):8249-55. PMID: 15548691.
    Citations: 116     Fields:    Translation:AnimalsCells
  47. Duensing A, Medeiros F, McConarty B, Joseph NE, Panigrahy D, Singer S, Fletcher CD, Demetri GD, Fletcher JA. Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs). Oncogene. 2004 May 13; 23(22):3999-4006. PMID: 15007386.
    Citations: 75     Fields:    Translation:HumansCells
  48. Panigrahy D, Shen LQ, Kieran MW, Kaipainen A. Therapeutic potential of thiazolidinediones as anticancer agents. Expert Opin Investig Drugs. 2003 Dec; 12(12):1925-37. PMID: 14640937.
    Citations: 19     Fields:    Translation:HumansAnimals
  49. Panigrahy D, Singer S, Shen LQ, Butterfield CE, Freedman DA, Chen EJ, Moses MA, Kilroy S, Duensing S, Fletcher C, Fletcher JA, Hlatky L, Hahnfeldt P, Folkman J, Kaipainen A. PPARgamma ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis. J Clin Invest. 2002 Oct; 110(7):923-32. PMID: 12370270.
    Citations: 122     Fields:    Translation:HumansAnimals
  50. Rupnick MA, Panigrahy D, Zhang CY, Dallabrida SM, Lowell BB, Langer R, Folkman MJ. Adipose tissue mass can be regulated through the vasculature. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10730-5. PMID: 12149466.
    Citations: 190     Fields:    Translation:Animals
  51. Stewart RJ, Panigrahy D, Flynn E, Folkman J. Vascular endothelial growth factor expression and tumor angiogenesis are regulated by androgens in hormone responsive human prostate carcinoma: evidence for androgen dependent destabilization of vascular endothelial growth factor transcripts. J Urol. 2001 Feb; 165(2):688-93. PMID: 11176459.
    Citations: 27     Fields:    Translation:HumansCells
  52. Beecken WD, Fernandez A, Panigrahy D, Achilles EG, Kisker O, Flynn E, Joussen AM, Folkman J, Shing Y. Efficacy of antiangiogenic therapy with TNP-470 in superficial and invasive bladder cancer models in mice. Urology. 2000 Sep 01; 56(3):521-6. PMID: 10962337.
    Citations: 2     Fields:    Translation:AnimalsCells
  53. Udagawa T, Yuan J, Panigrahy D, Chang YH, Shah J, D'Amato RJ. Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. J Pharmacol Exp Ther. 2000 Aug; 294(2):421-7. PMID: 10900214.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  54. Verheul HM, Panigrahy D, Flynn E, Pinedo HM, D'Amato RJ. Treatment of the Kasabach-Merritt syndrome with pegylated recombinant human megakaryocyte growth and development factor in mice: elevated platelet counts, prolonged survival, and tumor growth inhibition. Pediatr Res. 1999 Nov; 46(5):562-5. PMID: 10541319.
    Citations:    Fields:    Translation:HumansAnimalsCells
  55. Zhao H, Bojanowski K, Ingber DE, Panigrahy D, Pepper MS, Montesano R, Shing Y. New role for tRNA and its fragment purified from human urinary bladder carcinoma conditioned medium: inhibition of endothelial cell growth. J Cell Biochem. 1999 Nov; 76(1):109-17. PMID: 10581005.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  56. Hahnfeldt P, Panigrahy D, Folkman J, Hlatky L. Tumor development under angiogenic signaling: a dynamical theory of tumor growth, treatment response, and postvascular dormancy. Cancer Res. 1999 Oct 01; 59(19):4770-5. PMID: 10519381.
    Citations: 78     Fields:    Translation:AnimalsCells
  57. Verheul HM, Panigrahy D, Yuan J, D'Amato RJ. Combination oral antiangiogenic therapy with thalidomide and sulindac inhibits tumour growth in rabbits. Br J Cancer. 1999 Jan; 79(1):114-8. PMID: 10408702.
    Citations: 14     Fields:    Translation:Animals
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.