Harvard Catalyst Profiles

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Harold Fisher Dvorak, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA142262 (DVORAK, HAROLD FISHER) Jul 16, 2009 - Jun 30, 2014
    NIH/NCI
    VEGFs in tumor lymphatic metastasis
    Role: Principal Investigator
  2. P01CA092644 (DVORAK, HAROLD FISHER) Jul 1, 2001 - Mar 31, 2014
    NIH/NCI
    Spatial and Temporal Regulation of Angiogenesis
    Role: Principal Investigator
  3. R01HL064402 (DVORAK, HAROLD FISHER) Jan 1, 2001 - Jun 30, 2010
    NIH/NHLBI
    Adenoviral vectors for delivery of angiogenic cytokines
    Role: Principal Investigator
  4. T32HL007893 (DVORAK, HAROLD FISHER) Jul 1, 1998 - Jun 30, 2018
    NIH/NHLBI
    Training Program in Angiogenesis and Inflammation
    Role: Principal Investigator
  5. R13HL059361 (DVORAK, HAROLD FISHER) Sep 2, 1997 - Sep 1, 1998
    NIH/NHLBI
    GORDON RESEARCH--ANGIOGENESIS AND MICROCIRCULATION
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Dvorak HF. Tumors: Wounds That Do Not Heal-A Historical Perspective with a Focus on the Fundamental Roles of Increased Vascular Permeability and Clotting. Semin Thromb Hemost. 2019 May 16. PMID: 31096305.
    Citations:    
  2. Sitohy B, Chang S, Sciuto TE, Masse E, Shen M, Kang PM, Jaminet SC, Benjamin LE, Bhatt RS, Dvorak AM, Nagy JA, Dvorak HF. Early Actions of Anti-Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor Drugs on Angiogenic Blood Vessels. Am J Pathol. 2017 Oct; 187(10):2337-2347. PMID: 28736316.
    Citations:    Fields:    Translation:AnimalsCells
  3. Bridgeman VL, Vermeulen PB, Foo S, Bilecz A, Daley F, Kostaras E, Nathan MR, Wan E, Frentzas S, Schweiger T, Hegedus B, Hoetzenecker K, Renyi-Vamos F, Kuczynski EA, Vasudev NS, Larkin J, Gore M, Dvorak HF, Paku S, Kerbel RS, Dome B, Reynolds AR. Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models. J Pathol. 2017 Feb; 241(3):362-374. PMID: 27859259.
    Citations: 20     Fields:    Translation:Humans
  4. Uhlik MT, Liu J, Falcon BL, Iyer S, Stewart J, Celikkaya H, O'Mahony M, Sevinsky C, Lowes C, Douglass L, Jeffries C, Bodenmiller D, Chintharlapalli S, Fischl A, Gerald D, Xue Q, Lee JY, Santamaria-Pang A, Al-Kofahi Y, Sui Y, Desai K, Doman T, Aggarwal A, Carter JH, Pytowski B, Jaminet SC, Ginty F, Nasir A, Nagy JA, Dvorak HF, Benjamin LE. Stromal-Based Signatures for the Classification of Gastric Cancer. Cancer Res. 2016 05 01; 76(9):2573-86. PMID: 27197264.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  5. Connor Y, Tekleab S, Nandakumar S, Walls C, Tekleab Y, Husain A, Gadish O, Sabbisetti V, Kaushik S, Sehrawat S, Kulkarni A, Dvorak H, Zetter B, R Edelman E, Sengupta S. Physical nanoscale conduit-mediated communication between tumour cells and the endothelium modulates endothelial phenotype. Nat Commun. 2015 Dec 16; 6:8671. PMID: 26669454.
    Citations: 10     Fields:    Translation:HumansCells
  6. Sciuto TE, Merley A, Lin CI, Richardson D, Liu Y, Li D, Dvorak AM, Dvorak HF, Jaminet SC. Intracellular distribution of TM4SF1 and internalization of TM4SF1-antibody complex in vascular endothelial cells. Biochem Biophys Res Commun. 2015 Sep 25; 465(3):338-43. PMID: 26241677.
    Citations: 2     Fields:    Translation:HumansCells
  7. Dvorak HF. Tumor Stroma, Tumor Blood Vessels, and Antiangiogenesis Therapy. Cancer J. 2015 Jul-Aug; 21(4):237-43. PMID: 26222073.
    Citations: 17     Fields:    Translation:HumansCells
  8. Visintin A, Knowlton K, Tyminski E, Lin CI, Zheng X, Marquette K, Jain S, Tchistiakova L, Li D, O'Donnell CJ, Maderna A, Cao X, Dunn R, Snyder WB, Abraham AK, Leal M, Shetty S, Barry A, Zawel L, Coyle AJ, Dvorak HF, Jaminet SC. Novel Anti-TM4SF1 Antibody-Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature. Mol Cancer Ther. 2015 Aug; 14(8):1868-76. PMID: 26089370.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  9. Dvorak HF. Tumors: wounds that do not heal-redux. Cancer Immunol Res. 2015 Jan; 3(1):1-11. PMID: 25568067.
    Citations: 51     Fields:    Translation:HumansCells
  10. Sadow PM, Priolo C, Nanni S, Karreth FA, Duquette M, Martinelli R, Husain A, Clohessy J, Kutzner H, Mentzel T, Carman CV, Farsetti A, Henske EP, Palescandolo E, Macconaill LE, Chung S, Fadda G, Lombardi CP, De Angelis AM, Durante O, Parker JA, Pontecorvi A, Dvorak HF, Fletcher C, Pandolfi PP, Lawler J, Nucera C. Role of BRAFV600E in the first preclinical model of multifocal infiltrating myopericytoma development and microenvironment. J Natl Cancer Inst. 2014 Aug; 106(8). PMID: 25063326.
    Citations: 8     Fields:    Translation:HumansCells
  11. Rowe GC, Raghuram S, Jang C, Nagy JA, Patten IS, Goyal A, Chan MC, Liu LX, Jiang A, Spokes KC, Beeler D, Dvorak H, Aird WC, Arany Z. PGC-1a induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle. Circ Res. 2014 Aug 15; 115(5):504-17. PMID: 25009290.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  12. Lin CI, Merley A, Sciuto TE, Li D, Dvorak AM, Melero-Martin JM, Dvorak HF, Jaminet SC. TM4SF1: a new vascular therapeutic target in cancer. Angiogenesis. 2014 Oct; 17(4):897-907. PMID: 24986520.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  13. Qin L, Zhao D, Xu J, Ren X, Terwilliger EF, Parangi S, Lawler J, Dvorak HF, Zeng H. The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1. Blood. 2013 Mar 14; 121(11):2154-64. PMID: 23315169.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  14. Nagy JA, Dvorak HF. Heterogeneity of the tumor vasculature: the need for new tumor blood vessel type-specific targets. Clin Exp Metastasis. 2012 Oct; 29(7):657-62. PMID: 22692562.
    Citations: 33     Fields:    Translation:HumansAnimals
  15. Hoeppner LH, Phoenix KN, Clark KJ, Bhattacharya R, Gong X, Sciuto TE, Vohra P, Suresh S, Bhattacharya S, Dvorak AM, Ekker SC, Dvorak HF, Claffey KP, Mukhopadhyay D. Revealing the role of phospholipase Cß3 in the regulation of VEGF-induced vascular permeability. Blood. 2012 Sep 13; 120(11):2167-73. PMID: 22674805.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  16. Sitohy B, Nagy JA, Dvorak HF. Anti-VEGF/VEGFR therapy for cancer: reassessing the target. Cancer Res. 2012 Apr 15; 72(8):1909-14. PMID: 22508695.
    Citations: 88     Fields:    Translation:HumansAnimals
  17. Nagy JA, Dvorak AM, Dvorak HF. Vascular hyperpermeability, angiogenesis, and stroma generation. Cold Spring Harb Perspect Med. 2012 Feb; 2(2):a006544. PMID: 22355795.
    Citations: 36     Fields:    Translation:HumansCells
  18. Cao Y, Arbiser J, D'Amato RJ, D'Amore PA, Ingber DE, Kerbel R, Klagsbrun M, Lim S, Moses MA, Zetter B, Dvorak H, Langer R. Forty-year journey of angiogenesis translational research. Sci Transl Med. 2011 Dec 21; 3(114):114rv3. PMID: 22190240.
    Citations: 60     Fields:    Translation:Humans
  19. Sitohy B, Nagy JA, Jaminet SC, Dvorak HF. Tumor-surrogate blood vessel subtypes exhibit differential susceptibility to anti-VEGF therapy. Cancer Res. 2011 Nov 15; 71(22):7021-8. PMID: 21937680.
    Citations: 24     Fields:    Translation:AnimalsCells
  20. Zhao D, Qin L, Bourbon PM, James L, Dvorak HF, Zeng H. Orphan nuclear transcription factor TR3/Nur77 regulates microvessel permeability by targeting endothelial nitric oxide synthase and destabilizing endothelial junctions. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):12066-71. PMID: 21730126.
    Citations: 24     Fields:    Translation:AnimalsCells
  21. Zukauskas A, Merley A, Li D, Ang LH, Sciuto TE, Salman S, Dvorak AM, Dvorak HF, Jaminet SC. TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration. Angiogenesis. 2011 Sep; 14(3):345-54. PMID: 21626280.
    Citations: 14     Fields:    Translation:HumansCells
  22. Dvorak HF, Weaver VM, Tlsty TD, Bergers G. Tumor microenvironment and progression. J Surg Oncol. 2011 May 01; 103(6):468-74. PMID: 21480238.
    Citations: 55     Fields:    Translation:Humans
  23. Fu Y, Nagy JA, Brown LF, Shih SC, Johnson PY, Chan CK, Dvorak HF, Wight TN. Proteolytic cleavage of versican and involvement of ADAMTS-1 in VEGF-A/VPF-induced pathological angiogenesis. J Histochem Cytochem. 2011 May; 59(5):463-73. PMID: 21411713.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  24. Wada Y, Li D, Merley A, Zukauskas A, Aird WC, Dvorak HF, Shih SC. A multi-gene transcriptional profiling approach to the discovery of cell signature markers. Cytotechnology. 2011 Jan; 63(1):25-33. PMID: 20972619.
    Citations: 9     Fields:    
  25. Nagy JA, Chang SH, Shih SC, Dvorak AM, Dvorak HF. Heterogeneity of the tumor vasculature. Semin Thromb Hemost. 2010 Apr; 36(3):321-31. PMID: 20490982.
    Citations: 72     Fields:    Translation:HumansAnimals
  26. Dvorak HF. Vascular permeability to plasma, plasma proteins, and cells: an update. Curr Opin Hematol. 2010 May; 17(3):225-9. PMID: 20375889.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  27. Dvorak HF. My friend Marty. J Cutan Pathol. 2010 Apr; 37 Suppl 1:6-7. PMID: 20482669.
    Citations:    Fields:    Translation:Humans
  28. Chang SH, Feng D, Nagy JA, Sciuto TE, Dvorak AM, Dvorak HF. Vascular permeability and pathological angiogenesis in caveolin-1-null mice. Am J Pathol. 2009 Oct; 175(4):1768-76. PMID: 19729487.
    Citations: 38     Fields:    Translation: