My laboratory has 4 major areas of interest designed to aid in the development of effective vaccines and therapeutics against HIV and HCV: 1) Applying next-generation 454 sequencing approaches to investigate how these viruses evade critical immune responses in order to identify critical targets for vaccine design. 2) Investigating the role of viral replication capacity on disease progression in HIV and HCV infections to identify critical regions of the virus susceptible to host selection pressures, and testing of novel vaccine approaches in the humanized mouse model. 3) Identifying genetic, immunological and virological correlates of control of HIV in the Thai population which exhibits unique host and viral genetics. 4) Investigating evolution of HIV and HCV to intrinsic anti-viral host factors to identify novel host proteins related to the control of these viral infections.
I am also a member of the Ragon Institute (http://www.ragoninstitute.org/research_allen.html) and the Harvard Virology Department http://www.hms.harvard.edu/dms/virology/fac/allen.html) where additional information is provided.