Dennis Paul Orgill, M.D., PH.D.
|Title||Professor of Surgery|
|Institution||Brigham and Women's Hospital|
|Address||Div. of Plastic Surgery|
Brigham & Women's Hospital
Boston MA 02115
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Available: 05/02/17, Expires: 05/01/18
The student will join one of the main areas of investigation of our lab (Advanced scaffolds tissue engineering, Skin engineering, Modulation of soft tissue regeneration and healing through stem cells or mechanical forces, nerve regeneration) and will be supported in the drafting/proposal of a comprehensive research plan related to innovative strategies for therapeutic wound healing and induction of tissue regeneration in vivo (mice) and/or in vitro. The student will have the opportunity to familiarize him or herself with the state of the art research, translational and clinical literature on the topic as well as develop or strengthen her/his skills in critical review of literature, application of a correct scientific method, research plan development, drafting of experimental protocols (including animals) for funding applications, reporting and publishing research. He or she will have the ability to learn basic and advanced cell culture techniques as well as histological processing and staining methods. Hands-on surgical training with rodents will also be provided. Our research program fosters a collaborate environment in which students will have the opportunity to work with a large number of variegate investigators and labs (vascular surgery, general surgery, dermatology, orthopedics, diabetes, transplantation surgery, cell biology) in the surrounding region. Lab meetings are held weekly on Wednesday mornings at 8:30am where students will have the chance to share the progress of their research and hear updates on projects by fellow researchers.
Main ongoing investigations include among others:
- Optimization of an innovative method for soft tissue reconstruction through external volume expansion and fat grafting
- Use of Adipose Derived Stem Cells for skin wound healing, soft tissue regeneration and nerve regeneration
- Investigation of a newly discovered population of dermal mesenchymal stem cells for wound healing
- Tissue engineering of skin to avoid rejection
- Tissue engineering of adipose tissue for soft tissue reconstruction
- Creation of a “smart” collagen scaffold for non-invasive diagnostic through MR
Accelerated Regenerative Wound Healing with a Microarray Chamber Device and the Addition of Keratinocytes
Summer, 02/02/10 - 08/20/10
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