Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

HMS faculty, help us improve the algorithms in Profiles by uploading your CV!

Michelle Lai, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K23DK083439 (LAI, MICHELLE) Feb 15, 2010 - Jan 31, 2016
    Non-invasive evaluation of Non-alcoholic Steatohepatitis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Trivedi HD, Lopes EW, Glissen Brown J, Dudani S, Lai M, Feuerstein JD, Pierce TT. Steroid Use and Risk of Nonalcoholic Fatty Liver Disease in Patients With Inflammatory Bowel Disease: Systematic Review and Meta-analysis. J Clin Gastroenterol. 2022 Jun 01. PMID: 35648974.
    Citations:    Fields:    
  2. Vieira Barbosa J, Milligan S, Frick A, Broestl J, Younossi Z, Afdhal N, Lai M. Fibrosis-4 Index Can Independently Predict Major Adverse Cardiovascular Events in Nonalcoholic Fatty Liver Disease. Am J Gastroenterol. 2022 03 01; 117(3):453-461. PMID: 35041626.
    Citations:    Fields:    Translation:Humans
  3. Vieira Barbosa J, Milligan S, Frick A, Broestl J, Younossi Z, Afdhal NH, Lai M. Fibrosis-4 Index as an Independent Predictor of Mortality and Liver-Related Outcomes in NAFLD. Hepatol Commun. 2022 04; 6(4):765-779. PMID: 34970870; PMCID: PMC8948572.
    Citations:    Fields:    Translation:Humans
  4. Hu K, Perez-Matos MC, Argemi J, Vilar-Gomez E, Shalaurova I, Bullitt E, Landeen L, Sugahara G, Deng H, Mathur K, Tran S, Cai H, He H, Yalcin Y, Vieira Barbosa J, Ventura-Cots M, Marx K, Gad AP, Niezen S, Izunza Barba S, Ang LH, Popov YV, Fricker Z, Lai M, Curry M, Afdhal N, Szabo G, Mukamal KJ, Sanyal AJ, Otvos JD, Malik R, Saito T, Connelly MA, Chalasani NP, Bataller R, Jiang ZG. Lipoprotein Z, a hepatotoxic lipoprotein, predicts outcome in alcohol-associated hepatitis. Hepatology. 2022 04; 75(4):968-982. PMID: 34662439; PMCID: PMC9299888.
    Citations: 2     Fields:    Translation:Humans
  5. Trivedi HD, Danford CJ, Iriana S, Ochoa-Allemant P, Rourke M, Yang KC, Curry MP, Lai M. Comparison of transient elastography and Model for End-Stage Liver Disease-sodium to Model for End-Stage Liver Disease-sodium alone to predict mortality and liver transplantation. Eur J Gastroenterol Hepatol. 2021 12 01; 33(1S Suppl 1):e753-e757. PMID: 34231523.
    Citations:    Fields:    Translation:Humans
  6. Tiwari-Heckler S, Yee EU, Yalcin Y, Park J, Nguyen DT, Gao W, Csizmadia E, Afdhal N, Mukamal KJ, Robson SC, Lai M, Schwartz RE, Jiang ZG. Adenosine deaminase 2 produced by infiltrative monocytes promotes liver fibrosis in nonalcoholic fatty liver disease. Cell Rep. 2021 10 26; 37(4):109897. PMID: 34706243; PMCID: PMC8606247.
    Citations:    Fields:    Translation:HumansCells
  7. Niezen S, Tapper EB, Trivedi H, Lai M, Curry MP, Mukamal KJ, Jiang ZG. Prevalence of High Liver Stiffness and a Screening Strategy Using the SODA-2B Score Among US Adults. Hepatol Commun. 2022 04; 6(4):898-909. PMID: 34697916; PMCID: PMC8948660.
    Citations:    Fields:    Translation:Humans
  8. Vieira Barbosa J, Lai M. Strategies for a two-step liver fibrosis assessment in clinical practice. JHEP Rep. 2022 Jan; 4(1):100382. PMID: 34950862.
  9. Corey KE, Pitts R, Lai M, Loureiro J, Masia R, Osganian SA, Gustafson JL, Hutter MM, Gee DW, Meireles OR, Witkowski ER, Richards SM, Jacob J, Finkel N, Ngo D, Wang TJ, Gerszten RE, Ukomadu C, Jennings LL. ADAMTSL2 protein and a soluble biomarker signature identify at-risk non-alcoholic steatohepatitis and fibrosis in adults with NAFLD. J Hepatol. 2022 01; 76(1):25-33. PMID: 34600973; PMCID: PMC8688231.
    Citations: 1     Fields:    Translation:Humans
  10. Trivedi HD, Lai M, Curry M. Reduced steatosis and weight as a result of specific diets or the dietitian themselves. JHEP Rep. 2021 Dec; 3(6):100365. PMID: 34646998.
  11. Trivedi HD, Wilechansky R, Goyes D, Vieira Barbosa J, Canakis A, Lai M, Long MT, Fricker Z. Radiographic Hepatic Steatosis Is Not Associated With Key Clinical Outcomes Among Patients Hospitalized With COVID-19. Gastroenterology Res. 2021 Jun; 14(3):179-183. PMID: 34267833; PMCID: PMC8256898.
    Citations: 1     
  12. Trivedi HD, Curry MP, Lai M. Reply to: The presence of diabetes impacts liver fibrosis and steatosis by transient elastography in a primary care population. Ann Hepatol. 2021 Nov-Dec; 25:100347. PMID: 33845172.
    Citations:    Fields:    Translation:Humans
  13. Åberg F, Danford CJ, Thiele M, Talbäck M, Rasmussen DN, Jiang ZG, Hammar N, Nasr P, Ekstedt M, But A, Puukka P, Krag A, Sundvall J, Erlund I, Salomaa V, Stål P, Kechagias S, Hultcrantz R, Lai M, Afdhal N, Jula A, Männistö S, Lundqvist A, Perola M, Färkkilä M, Hagström H. A Dynamic Aspartate-to-Alanine Aminotransferase Ratio Provides Valid Predictions of Incident Severe Liver Disease. Hepatol Commun. 2021 Jun; 5(6):1021-1035. PMID: 34141987.
    Citations: 5     Fields:    
  14. Trivedi HD, Suri J, Oh D, Schwartz J, Goyes D, Idriss R, Curry MP, Lai M. The presence of diabetes impacts liver fibrosis and steatosis by transient elastography in a primary care population. Ann Hepatol. 2021 Sep-Oct; 24:100336. PMID: 33647502.
    Citations:    Fields:    Translation:Humans
  15. Vieira Barbosa J, Lai M. Nonalcoholic Fatty Liver Disease Screening in Type 2 Diabetes Mellitus Patients in the Primary Care Setting. Hepatol Commun. 2021 02; 5(2):158-167. PMID: 33553966.
    Citations: 9     Fields:    Translation:Humans
  16. Danford CJ, Lee JY, Strohbehn IA, Corey KE, Lai M. Development of an Algorithm to Identify Cases of Nonalcoholic Steatohepatitis Cirrhosis in the Electronic Health Record. Dig Dis Sci. 2021 05; 66(5):1452-1460. PMID: 32535780.
    Citations: 2     Fields:    Translation:Humans
  17. An P, Wei LL, Zhao S, Sverdlov DY, Vaid KA, Miyamoto M, Kuramitsu K, Lai M, Popov YV. Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis. Nat Commun. 2020 05 12; 11(1):2362. PMID: 32398673.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  18. Ezaz G, Trivedi HD, Connelly MA, Filozof C, Howard K, L Parrish M, Kim M, Herman MA, Nasser I, Afdhal NH, Jiang ZG, Lai M. Differential Associations of Circulating MicroRNAs With Pathogenic Factors in NAFLD. Hepatol Commun. 2020 May; 4(5):670-680. PMID: 32363318.
    Citations: 5     Fields:    
  19. Yang W, Sui J, Ma Y, Simon TG, Petrick JL, Lai M, McGlynn KA, Campbell PT, Giovannucci EL, Chan AT, Zhang X. High Dietary Intake of Vegetable or Polyunsaturated Fats Is Associated With Reduced Risk of Hepatocellular Carcinoma. Clin Gastroenterol Hepatol. 2020 11; 18(12):2775-2783.e11. PMID: 31927110.
    Citations: 8     Fields:    Translation:HumansAnimals
  20. Dushay J, Lai M. Is Trimming the Fat Enough? Fibroblast Growth Factor 21 as An Emerging Treatment for Nonalcoholic Fatty Liver Disease. Hepatology. 2019 11; 70(5):1860-1862. PMID: 31134632.
    Citations:    Fields:    Translation:Humans
  21. Sandhu B, Perez Matos MC, Tran S, Zhong A, Csizmadia E, Kim M, Herman MA, Nasser I, Lai M, Jiang ZG. Quantitative digital pathology reveals association of cell-specific PNPLA3 transcription with NAFLD disease activity. JHEP Rep. 2019 Sep; 1(3):199-202. PMID: 32039370; PMCID: PMC7001539.
    Citations: 3     
  22. Danford CJ, Lai M. NAFLD: a multisystem disease that requires a multidisciplinary approach. Frontline Gastroenterol. 2019 Oct; 10(4):328-329. PMID: 31682642; PMCID: PMC6788273.
    Citations: 6     
  23. Ezaz G, Lai M. How the "Opt-In" Option Optimizes Organ Donation Rates. Dig Dis Sci. 2019 05; 64(5):1067-1069. PMID: 30734232.
    Citations: 6     Fields:    Translation:Humans
  24. Lai M, Afdhal NH. Liver Fibrosis Determination. Gastroenterol Clin North Am. 2019 06; 48(2):281-289. PMID: 31046975.
    Citations: 11     Fields:    Translation:Humans
  25. Danford CJ, Iriana S, Shen C, Curry MP, Lai M. Evidence of bias during liver transplant evaluation of non-alcoholic steatohepatitis cirrhosis patients. Liver Int. 2019 06; 39(6):1165-1173. PMID: 30809932.
    Citations: 3     Fields:    Translation:Humans
  26. Idriss R, Lai M. Editorial: stepwise risk stratification for both F3 and F4 fibrosis stage in NAFLD patients. Aliment Pharmacol Ther. 2018 12; 48(11-12):1317-1318. PMID: 30488626.
    Citations:    Fields:    Translation:Humans
  27. Danford CJ, Connelly MA, Shalaurova I, Kim M, Herman MA, Nasser I, Otvos JD, Afdhal NH, Jiang ZG, Lai M. A Pathophysiologic Approach Combining Genetics and Insulin Resistance to Predict the Severity of Nonalcoholic Fatty Liver Disease. Hepatol Commun. 2018 Dec; 2(12):1467-1478. PMID: 30556036; PMCID: PMC6287585.
    Citations: 6     Fields:    
  28. Jiang ZG, Tapper EB, Kim M, Connelly MA, Krawczyk SA, Yee EU, Herman MA, Mukamal KJ, Lai M. Genetic Determinants of Circulating Lipoproteins in Nonalcoholic Fatty Liver Disease. J Clin Gastroenterol. 2018 May/Jun; 52(5):444-451. PMID: 28362682; PMCID: PMC5623166.
    Citations: 4     Fields:    Translation:Humans
  29. Jiang ZG, Sandhu B, Feldbrügge L, Yee EU, Csizmadia E, Mitsuhashi S, Huang J, Afdhal NH, Robson SC, Lai M. Serum Activity of Macrophage-Derived Adenosine Deaminase 2 Is Associated With Liver Fibrosis in Nonalcoholic Fatty Liver Disease. Clin Gastroenterol Hepatol. 2018 07; 16(7):1170-1172. PMID: 29170098; PMCID: PMC5962372.
    Citations: 5     Fields:    Translation:HumansCells
  30. Kim MS, Krawczyk SA, Doridot L, Fowler AJ, Wang JX, Trauger SA, Noh HL, Kang HJ, Meissen JK, Blatnik M, Kim JK, Lai M, Herman MA. ChREBP regulates fructose-induced glucose production independently of insulin signaling. J Clin Invest. 2016 11 01; 126(11):4372-4386. PMID: 27669460; PMCID: PMC5096918.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  31. Pimentel CF, Lai M. Nutrition Interventions for Chronic Liver Diseases and Nonalcoholic Fatty Liver Disease. Med Clin North Am. 2016 Nov; 100(6):1303-1327. PMID: 27745596.
    Citations: 5     Fields:    Translation:Humans
  32. Kaswala DH, Lai M, Afdhal NH. Fibrosis Assessment in Nonalcoholic Fatty Liver Disease (NAFLD) in 2016. Dig Dis Sci. 2016 May; 61(5):1356-64. PMID: 27017224.
    Citations: 42     Fields:    Translation:Humans
  33. Tapper EB, Challies T, Nasser I, Afdhal NH, Lai M. The Performance of Vibration Controlled Transient Elastography in a US Cohort of Patients With Nonalcoholic Fatty Liver Disease. Am J Gastroenterol. 2016 05; 111(5):677-84. PMID: 26977758; PMCID: PMC4860094.
    Citations: 34     Fields:    Translation:Humans
  34. Tapper EB, Sengupta N, Hunink MG, Afdhal NH, Lai M. Erratum: Cost-Effective Evaluation of Nonalcoholic Fatty Liver Disease With NAFLD Fibrosis Score and Vibration-Controlled Transient Elastography. Am J Gastroenterol. 2016 Mar; 111(3):446. PMID: 27018125.
    Citations: 1     Fields:    
  35. Jiang ZG, Tapper EB, Connelly MA, Pimentel CF, Feldbrügge L, Kim M, Krawczyk S, Afdhal N, Robson SC, Herman MA, Otvos JD, Mukamal KJ, Lai M. Steatohepatitis and liver fibrosis are predicted by the characteristics of very low density lipoprotein in nonalcoholic fatty liver disease. Liver Int. 2016 08; 36(8):1213-20. PMID: 26815314; PMCID: PMC4942367.
    Citations: 15     Fields:    Translation:Humans
  36. Tapper EB, Hunink MG, Afdhal NH, Lai M, Sengupta N. Cost-Effectiveness Analysis: Risk Stratification of Nonalcoholic Fatty Liver Disease (NAFLD) by the Primary Care Physician Using the NAFLD Fibrosis Score. PLoS One. 2016; 11(2):e0147237. PMID: 26905872.
    Citations: 19     Fields:    Translation:Humans
  37. Tapper EB, Lai M. Weight loss results in significant improvements in quality of life for patients with nonalcoholic fatty liver disease: A prospective cohort study. Hepatology. 2016 Apr; 63(4):1184-9. PMID: 26698379.
    Citations: 19     Fields:    Translation:Humans
  38. Jiang ZG, de Boer IH, Mackey RH, Jensen MK, Lai M, Robson SC, Tracy R, Kuller LH, Mukamal KJ. Associations of insulin resistance, inflammation and liver synthetic function with very low-density lipoprotein: The Cardiovascular Health Study. Metabolism. 2016 Mar; 65(3):92-9. PMID: 26892520; PMCID: PMC4761104.
    Citations: 9     Fields:    Translation:Humans
  39. Pimentel CF, Jiang ZG, Otsubo T, Feldbrügge L, Challies TL, Nasser I, Robson S, Afdhal N, Lai M. Poor Inter-test Reliability Between CK18 Kits as a Biomarker of NASH. Dig Dis Sci. 2016 Mar; 61(3):905-12. PMID: 26462489; PMCID: PMC4761280.
    Citations: 8     Fields:    Translation:Humans
  40. Tapper EB, Finkelstein D, Mittleman MA, Piatkowski G, Chang M, Lai M. A Quality Improvement Initiative Reduces 30-Day Rate of Readmission for Patients With Cirrhosis. Clin Gastroenterol Hepatol. 2016 May; 14(5):753-9. PMID: 26407750; PMCID: PMC5394424.
    Citations: 41     Fields:    Translation:Humans
  41. Tapper EB, Sengupta N, Lai M, Horowitz G. A Decision Support Tool to Reduce Overtesting for Ceruloplasmin and Improve Adherence With Clinical Guidelines. JAMA Intern Med. 2015 Sep; 175(9):1561-2. PMID: 26029881.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  42. Tapper EB, Sengupta N, Hunink MG, Afdhal NH, Lai M. Cost-Effective Evaluation of Nonalcoholic Fatty Liver Disease With NAFLD Fibrosis Score and Vibration Controlled Transient Elastography. Am J Gastroenterol. 2015 Sep; 110(9):1298-304. PMID: 26303130.
    Citations: 24     Fields:    Translation:Humans
  43. Tapper EB, Sengupta N, Lai M, Horowitz G. Understanding and Reducing Ceruloplasmin Overuse with a Decision Support Intervention for Liver Disease Evaluation. Am J Med. 2016 Jan; 129(1):115.e17-22. PMID: 26254122.
    Citations: 2     Fields:    Translation:Humans
  44. Lai M. Is liver stiffness measurement to stage fibrosis in patients with nonalcoholic fatty liver disease ready for clinical use? Hepatology. 2015 Oct; 62(4):997-8. PMID: 25989922.
    Citations: 2     Fields:    Translation:Humans
  45. Tapper EB, Finkelstein D, Mittleman MA, Piatkowski G, Lai M. Standard assessments of frailty are validated predictors of mortality in hospitalized patients with cirrhosis. Hepatology. 2015 Aug; 62(2):584-90. PMID: 25846824.
    Citations: 67     Fields:    Translation:Humans
  46. Tapper EB, Krajewski K, Lai M, Challies T, Kane R, Afdhal N, Lau D. Simple non-invasive biomarkers of advanced fibrosis in the evaluation of non-alcoholic fatty liver disease. Gastroenterol Rep (Oxf). 2014 Nov; 2(4):276-80. PMID: 25002154.
    Citations: 22     
  47. Tapper EB, Lai M. Factors affecting adherence to a quality improvement checklist on an inpatient hepatology service. Proc (Bayl Univ Med Cent). 2014 Apr; 27(2):100-2. PMID: 24688186.
    Citations: 4     
  48. Mazer L, Tapper EB, Piatkowski G, Lai M. The need for antibiotic stewardship and treatment standardization in the care of cirrhotic patients with spontaneous bacterial peritonitis - a retrospective cohort study examining the effect of ceftriaxone dosing. F1000Res. 2014; 3:57. PMID: 25165535.
    Citations: 3     Fields:    
  49. Tapper EB, Rahni DO, Arnaout R, Lai M. The overuse of serum ceruloplasmin measurement. Am J Med. 2013 Oct; 126(10):926.e1-5. PMID: 23953876.
    Citations: 7     Fields:    Translation:Humans
  50. Lai M, Afdhal NH. Clinical utility of interleukin-28B testing in patients with genotype 1. Hepatology. 2012 Jul; 56(1):367-72. PMID: 22511388.
    Citations: 4     Fields:    Translation:HumansCells
  51. Kornek M, Lynch M, Mehta SH, Lai M, Exley M, Afdhal NH, Schuppan D. Circulating microparticles as disease-specific biomarkers of severity of inflammation in patients with hepatitis C or nonalcoholic steatohepatitis. Gastroenterology. 2012 Aug; 143(2):448-58. PMID: 22537612; PMCID: PMC3404266.
    Citations: 76     Fields:    Translation:HumansCellsCTClinical Trials
  52. Corey KE, Lai M, Gelrud LG, Misdraji J, Barlow LL, Zheng H, Andersson KL, Thiim M, Pratt DS, Chung RT. Non-high-density lipoprotein cholesterol as a biomarker for nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol. 2012 Jun; 10(6):651-6. PMID: 22330232.
    Citations: 23     Fields:    Translation:Humans
  53. Lai M, Afdhal NH. Editorial: staging liver fibrosis in hepatitis C: a challenge for this decade. Am J Gastroenterol. 2011 Dec; 106(12):2121-2. PMID: 22138940.
    Citations: 8     Fields:    Translation:Humans
  54. Lai MM, Ang WM, McGuiness M, Larke AB. Undertreatment of osteoporosis in regional Western Australia. Australas J Ageing. 2012 Jun; 31(2):110-4. PMID: 22676170.
    Citations: 6     Fields:    Translation:Humans
  55. Karp SJ, Johnson S, Evenson A, Curry MP, Manning D, Malik R, Lake-Bakaar G, Lai M, Hanto D. Minimising cold ischaemic time is essential in cardiac death donor-associated liver transplantation. HPB (Oxford). 2011 Jun; 13(6):411-6. PMID: 21609374.
    Citations: 8     Fields:    Translation:Humans
  56. Qu KZ, Zhang K, Ma W, Li H, Wang X, Zhang X, Giles F, Lai M, Afdhal NH, Albitar M. Ubiquitin-proteasome profiling for enhanced detection of hepatocellular carcinoma in patients with chronic liver disease. J Gastroenterol Hepatol. 2011 Apr; 26(4):751-8. PMID: 21418304.
    Citations: 6     Fields:    Translation:Humans
  57. Malik R, Lai M, Sadiq A, Farnan R, Mehta S, Nasser I, Challies T, Schuppan D, Afdhal N. Comparison of transient elastography, serum markers and clinical signs for the diagnosis of compensated cirrhosis. J Gastroenterol Hepatol. 2010 Sep; 25(9):1562-8. PMID: 20796156.
    Citations: 14     Fields:    Translation:Humans
  58. Lai M, Liaw YF. Chronic hepatitis B: past, present, and future. Clin Liver Dis. 2010 Aug; 14(3):531-46. PMID: 20638030.
    Citations: 10     Fields:    Translation:HumansCellsPHPublic Health
  59. Lai M, Afdhal NH. Health care quality measurement in the care of patients with cirrhosis. Clin Gastroenterol Hepatol. 2010 Aug; 8(8):649-50. PMID: 20478399.
    Citations: 4     Fields:    Translation:Humans
  60. Lai M. Do we need to change our national organ donation policy? Hepatology. 2010 May; 51(5):1479-82. PMID: 20432248.
    Citations: 1     Fields:    Translation:Humans
  61. Lai M, Afdhal N, Challies T. Liver masses and eosinophilia. Liver Int. 2008 Jan; 28(1):150. PMID: 18173566.
    Citations: 3     Fields:    Translation:Humans
  62. Lai M, Hyatt BJ, Nasser I, Curry M, Afdhal NH. The clinical significance of persistently normal ALT in chronic hepatitis B infection. J Hepatol. 2007 Dec; 47(6):760-7. PMID: 17928090.
    Citations: 96     Fields:    Translation:Humans
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Lai's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (245)
Co-Authors (34)
Similar People (60)
Same Department 
Physical Neighbors
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.