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Francesca Gori, Ph.D.

TitleAssistant Professor of Oral Medicine, Infection, and Immunity
InstitutionHarvard School of Dental Medicine
DepartmentOral Med - Infection + Immunity
AddressHarvard School of Dental Medicine
Oral Medicine, Infection & Immunity
188 Longwood Ave
Boston MA 02115
Phone617/726-3966
Fax617/432-1897
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 Biography 
 awards and honors
1993 - Sanchez Foundation Award for Young Investigators
2005 - Harold Frost Young Investigator Award
2007 - John Haddad Young Investigator Award

 Overview 
 overview
I have a longstanding interest in studying the cellular and molecular pathways underlying cell fate and differentiation. I identified a novel gene, Wdr5, which has a crucial role in chondrocyte and osteoblasts differentiation. Wdr5 is a BMP-2 regulated gene and is a critical component of a complex required for chromatin modifications associated with activation of gene expression. Since then my research has been focused to investigate the role of Wdr5 in bone biology using genetically manipulated mice, osteoblastic and chondrocytic cell lines as well as chicken embryos.

My research has been focused on investigating: 1) the role of Wdr5 in skeletal development and 2) the role of Wdr5 in the epigenetic regulation of osteoblastogenesis.
Our studies indicate that Wdr5 is expressed in developing chondrocytes and osteoblasts and plays a critical role in endochondral and intramembranous ossification. Generation of conditionally knockout mice, to ablate Wdr5 in progenitors cells is underway to further investigate the role of this gene in skeletal development. Wdr5 is a component of a histone lysine methyltransferase complex required for Histone 3 lysine 4 trimethylation (H3K4me3), a histone modification associated with activation of transcription.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Movérare-Skrtic S, Henning P, Liu X, Nagano K, Saito H, Börjesson AE, Sjögren K, Windahl SH, Farman H, Kindlund B, Engdahl C, Koskela A, Zhang FP, Eriksson EE, Zaman F, Hammarstedt A, Isaksson H, Bally M, Kassem A, Lindholm C, Sandberg O, Aspenberg P, Sävendahl L, Feng JQ, Tuckermann J, Tuukkanen J, Poutanen M, Baron R, Lerner UH, Gori F, Ohlsson C. Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures. Nat Med. 2014 Nov; 20(11):1279-88.
    View in: PubMed
  2. Lisse TS, Saini V, Zhao H, Luderer HF, Gori F, Demay MB. The Vitamin D Receptor Is Required for Activation of cWnt and Hedgehog Signaling in Keratinocytes. Mol Endocrinol. 2014 Oct; 28(10):1698-706.
    View in: PubMed
  3. Liu ES, Zalutskaya A, Chae BT, Zhu ED, Gori F, Demay MB. Phosphate Interacts With PTHrP to Regulate Endochondral Bone Formation. Endocrinology. 2014 Oct; 155(10):3750-6.
    View in: PubMed
  4. Addison WN, Fu MM, Yang HX, Lin Z, Nagano K, Gori F, Baron R. Direct Transcriptional Repression of Zfp423 by Zfp521 Mediates a Bone Morphogenic Protein-Dependent Osteoblast versus Adipocyte Lineage Commitment Switch. Mol Cell Biol. 2014 Aug 15; 34(16):3076-85.
    View in: PubMed
  5. Barbati E, Specchia C, Villella M, Rossi ML, Barlera S, Bottazzi B, Crociati L, d'Arienzo C, Fanelli R, Garlanda C, Gori F, Mango R, Mantovani A, Merla G, Nicolis EB, Pietri S, Presbitero P, Sudo Y, Villella A, Franzosi MG. Influence of pentraxin 3 (PTX3) genetic variants on myocardial infarction risk and PTX3 plasma levels. PLoS One. 2012; 7(12):e53030.
    View in: PubMed
  6. Borghi R, Gori F, Korotkova O, Santarsiero M. Propagation of cross-spectral densities from spherical sources. Opt Lett. 2012 Aug 1; 37(15):3183-5.
    View in: PubMed
  7. Baron R, Saito H, Gori F. Bone cells crosstalk: noncanonical Roring in the Wnt. Cell Metab. 2012 Apr 4; 15(4):415-7.
    View in: PubMed
  8. Masson S, Gori F, Latini R, Milani V, Flyvbjerg A, Frystyk J, Crociati L, Pietri S, Vago T, Barlera S, Maggioni AP, Tognoni G, Tavazzi L, Omland T, Franzosi MG. Adiponectin in chronic heart failure: influence of diabetes and genetic variants. Eur J Clin Invest. 2011 Dec; 41(12):1330-8.
    View in: PubMed
  9. Luderer HF, Gori F, Demay MB. Lymphoid enhancer-binding factor-1 (LEF1) interacts with the DNA-binding domain of the vitamin D receptor. J Biol Chem. 2011 May 27; 286(21):18444-51.
    View in: PubMed
  10. Gori F, Mulinacci B, Massai L, Avolio C, Caragnano M, Peroni E, Lori S, Chelli M, Papini AM, Rovero P, Lolli F. IgG and IgM antibodies to the refolded MOG(1-125) extracellular domain in humans. J Neuroimmunol. 2011 Apr; 233(1-2):216-20.
    View in: PubMed
  11. Zhu S, Zhu ED, Provot S, Gori F. Wdr5 is required for chick skeletal development. J Bone Miner Res. 2010 Nov; 25(11):2504-14.
    View in: PubMed
  12. Chiodini BD, Specchia C, Gori F, Barlera S, D'Orazio A, Pietri S, Crociati L, Nicolucci A, Franciosi M, Signorini S, Brambilla P, Grazia Franzosi M. Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population. Ther Adv Cardiovasc Dis. 2010 Aug; 4(4):223-30.
    View in: PubMed
  13. Mannucci E, Monami M, Di Bari M, Lamanna C, Gori F, Gensini GF, Marchionni N. Cardiac safety profile of rosiglitazone: a comprehensive meta-analysis of randomized clinical trials. Int J Cardiol. 2010 Aug 20; 143(2):135-40.
    View in: PubMed
  14. Gori F, Zhu ED, Demay MB. Perichondrial expression of Wdr5 regulates chondrocyte proliferation and differentiation. Dev Biol. 2009 May 1; 329(1):36-43.
    View in: PubMed
  15. Gori F, Santarsiero M, Borghi R. Modal expansion for J0-correlated electromagnetic sources. Opt Lett. 2008 Aug 15; 33(16):1857-9.
    View in: PubMed
  16. Gori F, Santarsiero M, Borghi R, Ramírez-Sánchez V. Realizability condition for electromagnetic Schell-model sources. J Opt Soc Am A Opt Image Sci Vis. 2008 May; 25(5):1016-21.
    View in: PubMed
  17. Zhu ED, Demay MB, Gori F. Wdr5 is essential for osteoblast differentiation. J Biol Chem. 2008 Mar 21; 283(12):7361-7.
    View in: PubMed
  18. Gori F, Santarsiero M. Devising genuine spatial correlation functions. Opt Lett. 2007 Dec 15; 32(24):3531-3.
    View in: PubMed
  19. Di Renzo GC, Donati Sarti R, Gori F, Gerli S. [Tocolysis: which are the benefits?]. Minerva Ginecol. 2006 Dec; 58(6):479-87.
    View in: PubMed
  20. Gori F, Friedman LG, Demay MB. Wdr5, a WD-40 protein, regulates osteoblast differentiation during embryonic bone development. Dev Biol. 2006 Jul 15; 295(2):498-506.
    View in: PubMed
  21. Gori F, Friedman L, Demay MB. Wdr5, a novel WD repeat protein, regulates osteoblast and chondrocyte differentiation in vivo. J Musculoskelet Neuronal Interact. 2005 Oct-Dec; 5(4):338-9.
    View in: PubMed
  22. Gori F, Demay MB. The effects of BIG-3 on osteoblast differentiation are not dependent upon endogenously produced BMPs. Exp Cell Res. 2005 Mar 10; 304(1):287-92.
    View in: PubMed
  23. Gori F, Demay MB. BIG-3, a novel WD-40 repeat protein, is expressed in the developing growth plate and accelerates chondrocyte differentiation in vitro. Endocrinology. 2004 Mar; 145(3):1050-4.
    View in: PubMed
  24. Gori F, Divieti P, Demay MB. Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation. J Biol Chem. 2001 Dec 7; 276(49):46515-22.
    View in: PubMed
  25. Burguera B, Hofbauer LC, Thomas T, Gori F, Evans GL, Khosla S, Riggs BL, Turner RT. Leptin reduces ovariectomy-induced bone loss in rats. Endocrinology. 2001 Aug; 142(8):3546-53.
    View in: PubMed
  26. Gori F. Polarization basis for vortex beams. J Opt Soc Am A Opt Image Sci Vis. 2001 Jul; 18(7):1612-7.
    View in: PubMed
  27. Gori F, Schipani E, Demay MB. Fibromodulin is expressed by both chondrocytes and osteoblasts during fetal bone development. J Cell Biochem. 2001 Apr 2-27; 82(1):46-57.
    View in: PubMed
  28. Gori F, Hofbauer LC, Dunstan CR, Spelsberg TC, Khosla S, Riggs BL. The expression of osteoprotegerin and RANK ligand and the support of osteoclast formation by stromal-osteoblast lineage cells is developmentally regulated. Endocrinology. 2000 Dec; 141(12):4768-76.
    View in: PubMed
  29. Gori F, Hofbauer LC, Conover CA, Khosla S. Effects of androgens on the insulin-like growth factor system in an androgen-responsive human osteoblastic cell line. Endocrinology. 1999 Dec; 140(12):5579-86.
    View in: PubMed
  30. Thomas T, Gori F, Spelsberg TC, Khosla S, Riggs BL, Conover CA. Response of bipotential human marrow stromal cells to insulin-like growth factors: effect on binding protein production, proliferation, and commitment to osteoblasts and adipocytes. Endocrinology. 1999 Nov; 140(11):5036-44.
    View in: PubMed
  31. Hofbauer LC, Gori F, Riggs BL, Lacey DL, Dunstan CR, Spelsberg TC, Khosla S. Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis. Endocrinology. 1999 Oct; 140(10):4382-9.
    View in: PubMed
  32. Gori F, Thomas T, Hicok KC, Spelsberg TC, Riggs BL. Differentiation of human marrow stromal precursor cells: bone morphogenetic protein-2 increases OSF2/CBFA1, enhances osteoblast commitment, and inhibits late adipocyte maturation. J Bone Miner Res. 1999 Sep; 14(9):1522-35.
    View in: PubMed
  33. Santarsiero M, Gori F, Borghi R, Guattari G. Evaluation of the modal structure of light beams composed of incoherent mixtures of Hermite-Gaussian modes. Appl Opt. 1999 Sep 1; 38(25):5272-81.
    View in: PubMed
  34. Borgia MC, Gori F, Pellicelli A, Curcio D, Lionetti M, Buccarella PA, Lucidi M. Influence of thrombolytic therapy on inferior acute myocardial infarction with concomitant anterior ST segment depression. Angiology. 1999 Aug; 50(8):619-28.
    View in: PubMed
  35. Thomas T, Gori F, Khosla S, Jensen MD, Burguera B, Riggs BL. Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology. 1999 Apr; 140(4):1630-8.
    View in: PubMed
  36. Fiorelli G, Frediani U, Martineti V, Franchi A, Gori F, Franceschelli F, Tanini A, Serio M, Brandi ML. Aromatase expression and activity in the human leukaemic cell line FLG 29.1. J Steroid Biochem Mol Biol. 1998 Aug; 66(3):105-12.
    View in: PubMed
  37. Gori F, Santarsiero M, Borghi R, Guattari G. Intensity-based modal analysis of partially coherent beams with Hermite-Gaussian modes. Opt Lett. 1998 Jul 1; 23(13):989-91.
    View in: PubMed
  38. Hicok KC, Thomas T, Gori F, Rickard DJ, Spelsberg TC, Riggs BL. Development and characterization of conditionally immortalized osteoblast precursor cell lines from human bone marrow stroma. J Bone Miner Res. 1998 Feb; 13(2):205-17.
    View in: PubMed
  39. Rickard DJ, Hofbauer LC, Bonde SK, Gori F, Spelsberg TC, Riggs BL. Bone morphogenetic protein-6 production in human osteoblastic cell lines. Selective regulation by estrogen. J Clin Invest. 1998 Jan 15; 101(2):413-22.
    View in: PubMed
  40. Fiorelli G, Martineti V, Gori F, Benvenuti S, Frediani U, Formigli L, Zecchi S, Brandi ML. Heterogeneity of binding sites and bioeffects of raloxifene on the human leukemic cell line FLG 29.1. Biochem Biophys Res Commun. 1997 Nov 26; 240(3):573-9.
    View in: PubMed
  41. Gori F, Taddei GL, Pedemonte E, Ciaccheri M. [Sarcoidosis with predominant cardiac involvement]. Cardiologia. 1997 Apr; 42(4):421-3.
    View in: PubMed
  42. Fiorelli G, Gori F, Frediani U, Franceschelli F, Tanini A, Tosti-Guerra C, Benvenuti S, Gennari L, Becherini L, Brandi ML. Membrane binding sites and non-genomic effects of estrogen in cultured human pre-osteoclastic cells. J Steroid Biochem Mol Biol. 1996 Oct; 59(2):233-40.
    View in: PubMed
  43. Fiorelli G, Formigli L, Zecchi Orlandini S, Gori F, Falchetti A, Morelli A, Tanini A, Benvenuti S, Brandi ML. Characterization and function of the receptor for IGF-I in human preosteoclastic cells. Bone. 1996 Mar; 18(3):269-76.
    View in: PubMed
  44. Fiorelli G, Gori F, Frediani U, Morelli AM, Falchetti A, Benvenuti S, Masi L, Brandi ML. Evidence for bioeffects of LY 139478 on the human pre-osteoclastic cell line FLG 29.1. Biochem Biophys Res Commun. 1995 Jun 26; 211(3):857-63.
    View in: PubMed
  45. Fiorelli G, Gori F, Petilli M, Tanini A, Benvenuti S, Serio M, Bernabei P, Brandi ML. Functional estrogen receptors in a human preosteoclastic cell line. Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7):2672-6.
    View in: PubMed
  46. Petilli M, Fiorelli G, Benvenuti S, Frediani U, Gori F, Brandi ML. Interactions between ipriflavone and the estrogen receptor. Calcif Tissue Int. 1995 Feb; 56(2):160-5.
    View in: PubMed
  47. Fiorelli G, Ballock RT, Wakefield LM, Sporn MB, Gori F, Masi L, Frediani U, Tanini A, Bernabei PA, Brandi ML. Role for autocrine TGF-beta 1 in regulating differentiation of a human leukemic cell line toward osteoclast-like cells. J Cell Physiol. 1994 Sep; 160(3):482-90.
    View in: PubMed
  48. Caldarella A, Gori F, Bartoloni Saint-Omer F, Sarti A. [Reye's syndrome and hemophagocytic histiocytosis in a 16-month-old boy: is there a possible common etiopathogenetic basis?]. Pathologica. 1994 Jun; 86(3):329-32.
    View in: PubMed
  49. Bifarini G, Spaccatini A, Ciammitti B, Falconi S, Gori F. [Sedation with continuously infused propofol in caudal block for elective pediatric surgery]. Minerva Anestesiol. 1992 Apr; 58(4):181-4.
    View in: PubMed
  50. Gori F, Spaccatini A, Falconi S, Pasqualucci A, Bifarini G, Ciammitti B. [Postoperative analgesia in transvesical prostatic surgery with spinal morphine]. Minerva Anestesiol. 1991 Sep; 57(9):489-90.
    View in: PubMed
  51. Gori F, Moretti I, Mosca S, Pasqualucci A. [Intra-arterial diazepam. Treatment and evolution of a case]. Minerva Anestesiol. 1991 Jul-Aug; 57(7-8):445-7.
    View in: PubMed
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