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Francesca Gori, Ph.D.

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Biography
1993
Sanchez Foundation Award for Young Investigators
2005
Harold Frost Young Investigator Award
2007
John Haddad Young Investigator Award

Overview
My longstanding interest is to explore the molecular, cellular and genetic basis of skeletal homeostasis and its regulation in health and disease.WNT signaling controls cell fate decision and tissue homeostasis. WNT signaling in bone has been studied intensively in recent years. However, not all key aspects of how it regulates bone mass are clear and the regulation of signaling specificity between different WNT cascades remain puzzling. Given that WNT signaling can be targeted for drug development, insights into these mechanisms might translate into new therapeutic approaches for rare and common skeletal disorders. Ongoing studies on the role of WNT inhibitors and agonists in skeletal homeostasis are part of the current focus of the lab.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DE029615 (GORI, FRANCESCA) May 8, 2020 - Apr 30, 2025
    NIH/NIDCR
    Biology of cortical bone of long bones and calvarium: Role of Sfrp4 in periosteal bone formation
    Role: Principal Investigator
  2. R56DE028299 (GORI, FRANCESCA) Aug 1, 2019 - Jul 31, 2020
    NIH/NIDCR
    Biology of cortical bone of long bones and calvarium. Role of Sfrp4 in the local regulation of Wnt signaling
    Role: Principal Investigator
  3. R21DK076093 (GORI, FRANCESCA) Sep 30, 2006 - May 31, 2009
    NIH/NIDDK
    Role of Wdr5, a Novel BMP-2 Induced Gene, in Limb Development
    Role: Principal Investigator
  4. F32DE005754 (GORI, FRANCESCA) Sep 15, 2000
    NIH/NIDCR
    BMP-2 REGULATED GENES DURING ENDOCHONDRAL BONE FORMATION
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Idelevich A, Sato K, Avihai B, Nagano K, Galien A, Rowe G, Gori F, Baron R. Both NPY-Expressing and CART-Expressing Neurons Increase Energy Expenditure and Trabecular Bone Mass in Response to AP1 Antagonism, But Have Opposite Effects on Bone Resorption. J Bone Miner Res. 2020 Jun; 35(6):1107-1118. PMID: 31995643.
    Citations:    
  2. Idelevich A, Sato K, Nagano K, Rowe G, Gori F, Baron R. ?FosB Requires Galanin, but not Leptin, to Increase Bone Mass via the Hypothalamus, but both are needed to increase Energy expenditure. J Bone Miner Res. 2019 09; 34(9):1707-1720. PMID: 30998833.
    Citations:    
  3. Chen K, Ng PY, Chen R, Hu D, Berry S, Baron R, Gori F. Sfrp4 repression of the Ror2/Jnk cascade in osteoclasts protects cortical bone from excessive endosteal resorption. Proc Natl Acad Sci U S A. 2019 07 09; 116(28):14138-14143. PMID: 31239337.
    Citations:    
  4. Lotinun S, Ishihara Y, Nagano K, Kiviranta R, Carpentier VT, Neff L, Parkman V, Ide N, Hu D, Dann P, Brooks D, Bouxsein ML, Wysolmerski J, Gori F, Baron R. Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression. J Clin Invest. 2019 05 21; 129(8):3058-3071. PMID: 31112135.
    Citations:    
  5. Addison WN, Hall KC, Kokabu S, Matsubara T, Fu MM, Gori F, Baron R. Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation. Mol Cell Biol. 2019 04 15; 39(8). PMID: 30692273.
    Citations:    Fields:    
  6. Idelevich A, Sato K, Nagano K, Rowe G, Gori F, Baron R. Neuronal hypothalamic regulation of body metabolism and bone density is galanin dependent. J Clin Invest. 2018 06 01; 128(6):2626-2641. PMID: 29596063.
    Citations: 2     Fields:    
  7. Baron R, Gori F. Targeting WNT signaling in the treatment of osteoporosis. Curr Opin Pharmacol. 2018 06; 40:134-141. PMID: 29753194.
    Citations:    Fields:    
  8. Sato K, Idelevich A, Nagano K, Rowe GC, Gori F, Baron R. Hypothalamic ?FosB prevents age-related metabolic decline and functions via SNS. Aging (Albany NY). 2017 01 20; 9(2):353-369. PMID: 28121620.
    Citations:    Fields:    Translation:Animals
  9. Saini V, Zhao H, Petit ET, Gori F, Demay MB. Absence of vitamin D receptor (VDR)-mediated PPAR? suppression causes alopecia in VDR-null mice. FASEB J. 2017 03; 31(3):1059-1066. PMID: 27932380.
    Citations:    Fields:    Translation:AnimalsCells
  10. Gori F, Superti-Furga A, Baron R. Bone Formation and the Wnt Signaling Pathway. N Engl J Med. 2016 11 10; 375(19):1902-1903. PMID: 27959643.
    Citations: 1     Fields:    Translation:HumansCells
  11. Kiper POS, Saito H, Gori F, Unger S, Hesse E, Yamana K, Kiviranta R, Solban N, Liu J, Brommage R, Boduroglu K, Bonafé L, Campos-Xavier B, Dikoglu E, Eastell R, Gossiel F, Harshman K, Nishimura G, Girisha KM, Stevenson BJ, Takita H, Rivolta C, Superti-Furga A, Baron R. Cortical-Bone Fragility--Insights from sFRP4 Deficiency in Pyle's Disease. N Engl J Med. 2016 Jun 30; 374(26):2553-2562. PMID: 27355534.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  12. Zalli D, Neff L, Nagano K, Shin NY, Witke W, Gori F, Baron R. The Actin-Binding Protein Cofilin and Its Interaction With Cortactin Are Required for Podosome Patterning in Osteoclasts and Bone Resorption In Vivo and In Vitro. J Bone Miner Res. 2016 09; 31(9):1701-12. PMID: 27064822.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Shiwaku Y, Neff L, Nagano K, Takeyama K, de Bruijn J, Dard M, Gori F, Baron R. The Crosstalk between Osteoclasts and Osteoblasts Is Dependent upon the Composition and Structure of Biphasic Calcium Phosphates. PLoS One. 2015; 10(7):e0132903. PMID: 26193362.
    Citations: 3     Fields:    Translation:AnimalsCells
  14. Gori F, Lerner U, Ohlsson C, Baron R. A new WNT on the bone: WNT16, cortical bone thickness, porosity and fractures. Bonekey Rep. 2015; 4:669. PMID: 25987984.
    Citations: 10     
  15. Movérare-Skrtic S, Henning P, Liu X, Nagano K, Saito H, Börjesson AE, Sjögren K, Windahl SH, Farman H, Kindlund B, Engdahl C, Koskela A, Zhang FP, Eriksson EE, Zaman F, Hammarstedt A, Isaksson H, Bally M, Kassem A, Lindholm C, Sandberg O, Aspenberg P, Sävendahl L, Feng JQ, Tuckermann J, Tuukkanen J, Poutanen M, Baron R, Lerner UH, Gori F, Ohlsson C. Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures. Nat Med. 2014 Nov; 20(11):1279-88. PMID: 25306233.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  16. Lisse TS, Saini V, Zhao H, Luderer HF, Gori F, Demay MB. The vitamin D receptor is required for activation of cWnt and hedgehog signaling in keratinocytes. Mol Endocrinol. 2014 Oct; 28(10):1698-706. PMID: 25180455.
    Citations: 8     Fields:    Translation:AnimalsCells
  17. Liu ES, Zalutskaya A, Chae BT, Zhu ED, Gori F, Demay MB. Phosphate interacts with PTHrP to regulate endochondral bone formation. Endocrinology. 2014 Oct; 155(10):3750-6. PMID: 25057796.
    Citations: 2     Fields:    Translation:AnimalsCells
  18. Addison WN, Fu MM, Yang HX, Lin Z, Nagano K, Gori F, Baron R. Direct transcriptional repression of Zfp423 by Zfp521 mediates a bone morphogenic protein-dependent osteoblast versus adipocyte lineage commitment switch. Mol Cell Biol. 2014 Aug; 34(16):3076-85. PMID: 24891617.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  19. Baron R, Saito H, Gori F. Bone cells crosstalk: noncanonical Roring in the Wnt. Cell Metab. 2012 Apr 04; 15(4):415-7. PMID: 22482722.
    Citations: 2     Fields:    
  20. Luderer HF, Gori F, Demay MB. Lymphoid enhancer-binding factor-1 (LEF1) interacts with the DNA-binding domain of the vitamin D receptor. J Biol Chem. 2011 May 27; 286(21):18444-51. PMID: 21471213.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  21. Zhu S, Zhu ED, Provot S, Gori F. Wdr5 is required for chick skeletal development. J Bone Miner Res. 2010 Nov; 25(11):2504-14. PMID: 20533303.
    Citations: 1     Fields:    Translation:AnimalsCells
  22. Gori F, Zhu ED, Demay MB. Perichondrial expression of Wdr5 regulates chondrocyte proliferation and differentiation. Dev Biol. 2009 May 01; 329(1):36-43. PMID: 19217897.
    Citations: 4     Fields:    Translation:AnimalsCells
  23. Zhu ED, Demay MB, Gori F. Wdr5 is essential for osteoblast differentiation. J Biol Chem. 2008 Mar 21; 283(12):7361-7. PMID: 18201971.
    Citations: 21     Fields:    Translation:AnimalsCells
  24. Gori F, Friedman LG, Demay MB. Wdr5, a WD-40 protein, regulates osteoblast differentiation during embryonic bone development. Dev Biol. 2006 Jul 15; 295(2):498-506. PMID: 16730692.
    Citations: 18     Fields:    Translation:AnimalsCells
  25. Gori F, Friedman L, Demay MB. Wdr5, a novel WD repeat protein, regulates osteoblast and chondrocyte differentiation in vivo. J Musculoskelet Neuronal Interact. 2005 Oct-Dec; 5(4):338-9. PMID: 16340128.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  26. Gori F, Demay MB. The effects of BIG-3 on osteoblast differentiation are not dependent upon endogenously produced BMPs. Exp Cell Res. 2005 Mar 10; 304(1):287-92. PMID: 15707593.
    Citations:    Fields:    Translation:AnimalsCells
  27. Gori F, Demay MB. BIG-3, a novel WD-40 repeat protein, is expressed in the developing growth plate and accelerates chondrocyte differentiation in vitro. Endocrinology. 2004 Mar; 145(3):1050-4. PMID: 14657013.
    Citations: 8     Fields:    Translation:AnimalsCells
  28. Gori F, Divieti P, Demay MB. Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation. J Biol Chem. 2001 Dec 07; 276(49):46515-22. PMID: 11551928.
    Citations: 19     Fields:    Translation:AnimalsCells
  29. Burguera B, Hofbauer LC, Thomas T, Gori F, Evans GL, Khosla S, Riggs BL, Turner RT. Leptin reduces ovariectomy-induced bone loss in rats. Endocrinology. 2001 Aug; 142(8):3546-53. PMID: 11459801.
    Citations: 66     Fields:    Translation:AnimalsCells
  30. Gori F, Schipani E, Demay MB. Fibromodulin is expressed by both chondrocytes and osteoblasts during fetal bone development. J Cell Biochem. 2001 Apr 2-27; 82(1):46-57. PMID: 11400162.
    Citations: 6     Fields:    Translation:AnimalsCells
  31. Gori F, Hofbauer LC, Dunstan CR, Spelsberg TC, Khosla S, Riggs BL. The expression of osteoprotegerin and RANK ligand and the support of osteoclast formation by stromal-osteoblast lineage cells is developmentally regulated. Endocrinology. 2000 Dec; 141(12):4768-76. PMID: 11108292.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  32. Gori F, Hofbauer LC, Dunstan CR, Spelsberg TC, Khosla S, Riggs BL. The Expression of Osteoprotegerin and RANK Ligand and the Support of Osteoclast Formation by Stromal-Osteoblast Lineage Cells Is Developmentally Regulated* *This work was supported by Grant AG-04875 from the National Institute on Aging. Endocrinology. 2000 Dec 01; 141(12):4768-4776. PMID: 28200905.
    Citations:    
  33. Gori F, Hofbauer LC, Conover CA, Khosla S. Effects of androgens on the insulin-like growth factor system in an androgen-responsive human osteoblastic cell line. Endocrinology. 1999 Dec; 140(12):5579-86. PMID: 10579321.
    Citations: 11     Fields:    Translation:HumansCells
  34. Thomas T, Gori F, Spelsberg TC, Khosla S, Riggs BL, Conover CA. Response of bipotential human marrow stromal cells to insulin-like growth factors: effect on binding protein production, proliferation, and commitment to osteoblasts and adipocytes. Endocrinology. 1999 Nov; 140(11):5036-44. PMID: 10537129.
    Citations: 14     Fields:    Translation:HumansCells
  35. Thomas T, Gori F, Spelsberg TC, Khosla S, Riggs BL, Conover CA. Response of Bipotential Human Marrow Stromal Cells to Insulin-Like Growth Factors: Effect on Binding Protein Production, Proliferation, and Commitment to Osteoblasts and Adipocytes1. Endocrinology. 1999 Nov 01; 140(11):5036-5044. PMID: 28200724.
    Citations:    
  36. Hofbauer LC, Gori F, Riggs BL, Lacey DL, Dunstan CR, Spelsberg TC, Khosla S. Stimulation of Osteoprotegerin Ligand and Inhibition of Osteoprotegerin Production by Glucocorticoids in Human Osteoblastic Lineage Cells: Potential Paracrine Mechanisms of Glucocorticoid-Induced Osteoporosis1. Endocrinology. 1999 Oct 01; 140(10):4382-4389. PMID: 28200512.
    Citations:    
  37. Hofbauer LC, Gori F, Riggs BL, Lacey DL, Dunstan CR, Spelsberg TC, Khosla S. Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis. Endocrinology. 1999 Oct; 140(10):4382-9. PMID: 10499489.
    Citations: 115     Fields:    Translation:HumansCells
  38. Gori F, Thomas T, Hicok KC, Spelsberg TC, Riggs BL. Differentiation of human marrow stromal precursor cells: bone morphogenetic protein-2 increases OSF2/CBFA1, enhances osteoblast commitment, and inhibits late adipocyte maturation. J Bone Miner Res. 1999 Sep; 14(9):1522-35. PMID: 10469280.
    Citations: 46     Fields:    Translation:HumansCells
  39. Thomas T, Gori F, Khosla S, Jensen MD, Burguera B, Riggs BL. Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology. 1999 Apr; 140(4):1630-8. PMID: 10098497.
    Citations: 171     Fields:    Translation:HumansCells
  40. Fiorelli G, Frediani U, Martineti V, Franchi A, Gori F, Franceschelli F, Tanini A, Serio M, Brandi ML. Aromatase expression and activity in the human leukaemic cell line FLG 29.1. J Steroid Biochem Mol Biol. 1998 Aug; 66(3):105-12. PMID: 9719444.
    Citations: 3     Fields:    Translation:HumansCells
  41. Hicok KC, Thomas T, Gori F, Rickard DJ, Spelsberg TC, Riggs BL. Development and characterization of conditionally immortalized osteoblast precursor cell lines from human bone marrow stroma. J Bone Miner Res. 1998 Feb; 13(2):205-17. PMID: 9495513.
    Citations: 13     Fields:    Translation:HumansCells
  42. Rickard DJ, Hofbauer LC, Bonde SK, Gori F, Spelsberg TC, Riggs BL. Bone morphogenetic protein-6 production in human osteoblastic cell lines. Selective regulation by estrogen. J Clin Invest. 1998 Jan 15; 101(2):413-22. PMID: 9435314.
    Citations: 12     Fields:    Translation:HumansCells
  43. Fiorelli G, Martineti V, Gori F, Benvenuti S, Frediani U, Formigli L, Zecchi S, Brandi ML. Heterogeneity of binding sites and bioeffects of raloxifene on the human leukemic cell line FLG 29.1. Biochem Biophys Res Commun. 1997 Nov 26; 240(3):573-9. PMID: 9398606.
    Citations: 2     Fields:    Translation:HumansCells
  44. Fiorelli G, Gori F, Frediani U, Franceschelli F, Tanini A, Tosti-Guerra C, Benvenuti S, Gennari L, Becherini L, Brandi ML. Membrane binding sites and non-genomic effects of estrogen in cultured human pre-osteoclastic cells. J Steroid Biochem Mol Biol. 1996 Oct; 59(2):233-40. PMID: 9010339.
    Citations: 5     Fields:    Translation:HumansCells
  45. Fiorelli G, Formigli L, Zecchi Orlandini S, Gori F, Falchetti A, Morelli A, Tanini A, Benvenuti S, Brandi ML. Characterization and function of the receptor for IGF-I in human preosteoclastic cells. Bone. 1996 Mar; 18(3):269-76. PMID: 8703583.
    Citations: 9     Fields:    Translation:HumansCells
  46. Fiorelli G, Gori F, Frediani U, Morelli AM, Falchetti A, Benvenuti S, Masi L, Brandi ML. Evidence for bioeffects of LY 139478 on the human pre-osteoclastic cell line FLG 29.1. Biochem Biophys Res Commun. 1995 Jun 26; 211(3):857-63. PMID: 7598715.
    Citations: 1     Fields:    Translation:HumansCells
  47. Fiorelli G, Gori F, Petilli M, Tanini A, Benvenuti S, Serio M, Bernabei P, Brandi ML. Functional estrogen receptors in a human preosteoclastic cell line. Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7):2672-6. PMID: 7708703.
    Citations: 5     Fields:    Translation:HumansCells
  48. Petilli M, Fiorelli G, Benvenuti S, Frediani U, Gori F, Brandi ML. Interactions between ipriflavone and the estrogen receptor. Calcif Tissue Int. 1995 Feb; 56(2):160-5. PMID: 7736326.
    Citations: 3     Fields:    Translation:HumansCells
  49. Fiorelli G, Ballock RT, Wakefield LM, Sporn MB, Gori F, Masi L, Frediani U, Tanini A, Bernabei PA, Brandi ML. Role for autocrine TGF-beta 1 in regulating differentiation of a human leukemic cell line toward osteoclast-like cells. J Cell Physiol. 1994 Sep; 160(3):482-90. PMID: 8077286.
    Citations: 7     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.